Genes (Basel) 2021 May 13;12(5). Epub 2021 May 13.
Division of Medical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', A.O.U. Consorziale Policlinico di Bari, 70121 Bari, Italy.
Molecular alterations of the Ataxia-telangiectasia () gene are frequently detected in breast cancer (BC), with an incidence ranging up to 40%. The mutated form, the Ataxia-telangiectasia mutated () gene, is involved in cell cycle control, apoptosis, oxidative stress, and telomere maintenance, and its role as a risk factor for cancer development is well established. Recent studies have confirmed that some variants of are associated with an increased risk of BC development and a worse prognosis. Read More