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    Cardiopulmonary resuscitation: the science behind the hands.
    Heart 2018 Jan 20. Epub 2018 Jan 20.
    University of Washington, Division of Cardiology, Seattle, Washington, USA.
    Sudden cardiac arrest is a leading cause of death worldwide. Despite significant advances in resuscitation science since the initial use of external chest compressions in humans nearly 60 years ago, there continues to be wide variability in rates of successful resuscitation across communities. The American Heart Association (AHA) and European Resuscitation Council emphasise the importance of high-quality chest compressions as the foundation of resuscitation care. Read More

    Transitions Between Circulatory States After Out-of-Hospital Cardiac Arrest: Protocol for an Observational, Prospective Cohort Study.
    JMIR Res Protoc 2018 Jan 19;7(1):e17. Epub 2018 Jan 19.
    Department of Anesthesiology and Intensive Care Medicine, St. Olav's University Hospital, Trondheim, Norway.
    Background: The post cardiac arrest syndrome (PCAS) is responsible for the majority of in-hospital deaths following cardiac arrest (CA). The major elements of PCAS are anoxic brain injury and circulatory failure.

    Objective: This study aimed to investigate the clinical characteristics of circulatory failure and inflammatory responses after out-of-hospital cardiac arrest (OHCA) and to identify patterns of circulatory and inflammatory responses, which may predict circulatory deterioration in PCAS. Read More

    Which position should we take during newborn resuscitation? A prospective, randomized, multicentre simulation trial.
    Kardiol Pol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Emergency Medicine and Disaster, Medical University Bialystok, Bialystok, Poland; Department of Emergency Medicine, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland.
    Background: Early bystander cardiopulmonary resuscitation (CPR) for cardiac arrest is crucial in the chain of survival. Cardiac arrest in infants is rare but CPR is also performed in severe bradycardia. The European Resuscitation Council (ERC) and American Heart Association (AHA) guidelines recommend starting CPR and continuing it until the heart muscle is sufficiently oxygenated and regains sufficient contractility and function. Read More

    Sliding to predict: vision-based beating heart motion estimation by modeling temporal interactions.
    Int J Comput Assist Radiol Surg 2018 Jan 19. Epub 2018 Jan 19.
    The Research Center of Biomedical Engineering (CREB), Universitat Politècnica de Cataluya, Barcelona, Spain.
    Purpose: Technical advancements have been part of modern medical solutions as they promote better surgical alternatives that serve to the benefit of patients. Particularly with cardiovascular surgeries, robotic surgical systems enable surgeons to perform delicate procedures on a beating heart, avoiding the complications of cardiac arrest. This advantage comes with the price of having to deal with a dynamic target which presents technical challenges for the surgical system. Read More

    The Use of Adenosine to Enable Safe Implantation of Transcatheter Tricuspid Valve.
    Case Rep Cardiol 2017 16;2017:2760580. Epub 2017 Nov 16.
    Hadassah Hebrew University Medical Center, Jerusalem, Israel.
    High precision is necessary during percutaneous transcatheter heart valve implantation. The precision of the implantation has been established by increasing the heart rate (usually to 200 beats per minute) to the point of significantly reduced cardiac output and thus minimizing valve movement. Routinely, this tachycardia is induced by rapid pacing. Read More

    Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany.
    Diabetes Care 2018 Jan 18. Epub 2018 Jan 18.
    Institute of Health Economics and Health Care Management, Helmholtz Zentrum München (GmbH)-German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
    Objective: The aim of this study is to provide reliable regression-based estimates of costs associated with different type 2 diabetes complications.

    Research Design And Methods: We used nationwide statutory health insurance (SHI) data from 316,220 patients with type 2 diabetes. Costs for inpatient and outpatient care, pharmaceuticals, rehabilitation, and nonmedical aids and appliances were assessed in the years 2013-2015. Read More

    Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest in neonatal swine.
    Eur J Cardiothorac Surg 2018 Jan 15. Epub 2018 Jan 15.
    Department of Anesthesia and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    Objectives: Controversy remains regarding the use of deep hypothermic circulatory arrest (DHCA) in neonatal cardiac surgery. Alterations in cerebral mitochondrial bioenergetics are thought to contribute to ischaemia-reperfusion injury in DHCA. The purpose of this study was to compare cerebral mitochondrial bioenergetics for DHCA with deep hypothermic continuous perfusion using a neonatal swine model. Read More

    Limb-bud and Heart Overexpression Inhibits the Proliferation and Migration of PC3M Cells.
    J Cancer 2018 1;9(2):424-432. Epub 2018 Jan 1.
    State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, Sun Yat-sen University Cancer Center, Guangzhou 510660, China.
    Background: The limb-bud and heart gene (LBH) was discovered in the early 21st century and is specifically expressed in the mouse embryonic limb and heart development. Increasing evidences have indicated that LBH not only plays an important role in embryo development, it is also closely correlated with the occurance and progression of many tumors. However, its function in prostate cancer (PCa) is still not well understood. Read More

    Rapamycin activates TGF receptor independently of its ligand: implications for endothelial dysfunction.
    Clin Sci (Lond) 2018 Jan 17. Epub 2018 Jan 17.
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.
    Rapamycin, the macrolide immunosuppressant and active pharmaceutic in drug-eluting stents (DES), has a well-recognized anti-proliferative action that involves inhibition of the mTOR pathway after binding to the cytosolic protein FKBP12. TGF receptor-type I (TGFRI) spontaneous activation is inhibited by the association with FKBP12. We hypothesized that rapamycin, in addition to inhibition of mTOR signaling, activates TGFRI independent of TGFb. Read More

    [An analysis of clinical characteristics and acute treatment of supraventricular tachycardia in children from a multicenter study].
    Zhonghua Er Ke Za Zhi 2018 Jan;56(1):13-18
    Heart Center, Division of Pediatric Cardiology, First Hospital of Tsinghua University, Beijing 100016, China.
    Objective: The study assessed the clinical characteristics and response to acute intravenous antiarrhythmic drug therapy of supraventricular tachycardia (SVT) in children. Methods: This was a multicenter prospective descriptive study including 257 children from First Hospital of Tsinghua University, Peking University First Hospital, Children's Hospital Affiliated to Capital Institute of Pediatrics and Beijing Anzhen Hospital who received intravenous antiarrhythmic drug therapy for SVT from July 2014 to February 2017. The clinical and tachycardia features, response to intravenous antiarrhythmic drug therapy of these children were characterized. Read More

    In elective arch surgery with circulatory arrest, does the arterial cannulation site really matter? A propensity score analysis of right axillary and innominate artery cannulation.
    J Thorac Cardiovasc Surg 2017 Dec 19. Epub 2017 Dec 19.
    Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Tex.
    Objective: The preferred arterial cannulation site for elective proximal aortic procedures requiring circulatory arrest varies, and different sites have been tried. We evaluated the relationships between arterial cannulation site and adverse outcomes, including stroke, in patients undergoing elective aortic arch surgery.

    Methods: We reviewed the records of 938 patients who underwent elective hemiarch or total arch surgery with circulatory arrest between 2006 and 2016. Read More

    Successful operative treatment of uterine leiomyoma with extensive intravenous extension to the IVC, right heart, and pulmonary arteries.
    Acta Chir Belg 2018 Jan 17:1-4. Epub 2018 Jan 17.
    d Royal Sussex County Hospital , Sussex , UK.
    Introduction: Intravenous extension of benign uterine leiomyomata ('fibroids'), in the absence of discrete metastatic disease has rarely been reported. 'Fibroids' remain one of the most common premenopausal uterine pathologies.

    Methods And Results: We report the diagnosis and multidisciplinary led operative management of a 52-year-old woman with a histologically benign, but biologically aggressive, uterine leiomyoma with intravenous extension to the inferior vena cava (IVC), right heart and pulmonary arteries. Read More

    Failure of Intracardiac Pacing After Fatal Propafenone Overdose: A Case Report.
    J Emerg Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Cardiology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.
    Background: Propafenone is a sodium-channel blocker, class IC antiarrhythmic drug, frequently used to manage supraventricular dysrhythmias, especially atrial fibrillation. We report a self mono-intoxication with propafenone.

    Case Report: A 68-year-old woman presented with a decreased level of consciousness, hypotension, and electrocardiogram showing QRS widening with atrial asystole and extreme bradycardia < 20 beats/min. Read More

    Inability to Utilize Retrograde Cardioplegia due to a Persistent Left Superior Vena Cava.
    Case Rep Anesthesiol 2017 3;2017:4671856. Epub 2017 Dec 3.
    Cardiothoracic Section, Department of Anesthesiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157-1009, USA.
    A persistent left superior vena cava is a congenital abnormality that affects a minority of the general population. While this finding is not hemodynamically significant in all patients, failure to recognize the altered anatomy in any of these patients can be consequential during procedures such as central venous catheter placement, pacemaker/defibrillator wire placement, and use of retrograde cardioplegia during cardiac surgery. We present a case of an intraoperative diagnosis of a persistent left superior vena cava that altered the original plan to arrest the heart using retrograde cardioplegia. Read More

    Serelaxin for infant heart failure in congenital dilated cardiomyopathy.
    Cardiol Young 2018 Jan 15:1-3. Epub 2018 Jan 15.
    3Unit of Pediatric Cardiology,Children's University Hospital Geneva& Faculty of Medicine,Geneva,Switzerland.
    Serelaxin has been studied in trials in adults with acute heart failure, but not in children. We report the first compassionate use of serelaxin in an infant. A 6-month-old girl with dilated cardiomyopathy was placed on extracorporeal membrane oxygenation following cardiac arrest unresponsive to medical treatment. Read More

    Heparin-Coated Grafts Reduce Mortality in Pediatric Patients Receiving Systemic-to-Pulmonary Shunts.
    Pediatr Cardiol 2018 Jan 13. Epub 2018 Jan 13.
    Mattel Children's Hospital, Los Angeles, CA, USA.
    We aimed to evaluate the outcomes of systemic-to-pulmonary (SP) shunt procedures utilizing heparin-coated (HC) polytetrafluoroethylene (PTFE) vascular grafts compared to uncoated (non-HC) grafts, in order to observe any benefits in pediatric patients. Our institution switched from using non-HC grafts to HC grafts in March 2011. We conducted a retrospective review of consecutive pediatric patients receiving SP shunts from May 2008 to December 2015. Read More

    Echocardiographic patterns of postresuscitation myocardial dysfunction.
    Resuscitation 2018 Jan 11;124:90-95. Epub 2018 Jan 11.
    Department of Emergency Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea. Electronic address:
    Background: Postresuscitation myocardial dysfunction (PRMD) can develop after successful resuscitation from cardiac arrest. However, echocardiographic patterns of PRMD remain unknown. This study aimed to investigate PRMD manifestations with serial echocardiography during the post-cardiac arrest period. Read More

    The challenges and possibilities of public access defibrillation.
    J Intern Med 2018 Jan 13. Epub 2018 Jan 13.
    Emergency Medical Services Copenhagen, University of Copenhagen, Denmark.
    Out-of-Hospital Cardiac Arrest (OHCA) is a major health problem that affects approximately four hundred thousand patients annually in the United States alone. It is a major challenge for the emergency medical system since decreased survival rates are directly proportional to the time delay from collapse to defibrillation. Historically, defibrillation has only been performed by physicians and in-hospital. Read More

    Cell therapy for heart disease: current status and future directions.
    Minerva Cardioangiol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA -
    Treatment of ischemic heart disease has evolved considerably over time, seeing a technological impetus in recent times. Prompt diagnosis and progressively earlier reperfusion of the infarct artery have become the cornerstone of the early myocardial ischemia management. However, treatment of post-infarction sequelae resulting from ischemic damage sustained within the myocardium remains a considerable challenge. Read More

    Return to Work and Participation in Society After Out-of-Hospital Cardiac Arrest.
    Circ Cardiovasc Qual Outcomes 2018 Jan;11(1):e003566
    From the Department of Clinical Sciences (G.L., T.C.) and Department of Clinical Sciences, Anesthesiology and Intensive Care Medicine (N.N., H.F.), Skane University Hospital, Lund University, Sweden; Department of Cardiology, The Heart Center, Copenhagen University Hospital Rigshospitalet, Denmark (J.B.-J., J.K.); Adult Critical Care, University Hospital of Wales, Cardiff, United Kingdom (H.D., M.P.W.); Institute of Neuroscience and Physiology, Section of Health and Rehabilitation, Sahlgrenska Academy, University of Gothenburg, Sweden (C.H.); Intensive Care, Academic Medical Center, Amsterdam, The Netherlands (J.H., T.W.); Anesthesia and Intensive Care, IRCCS AOU San Martino IST, Genova, Italy (A.I.); Research and Development Centre Skane, Medical Statistics and Epidemiology, Lund, Sweden (F.N.); and Department of Surgical Sciences and Integrated Diagnostics, Ospedale Policlinico San Martino - IRCCS per l'Oncologia, University of Genova, Italy (P.P.).
    Background: The aim of this study was to describe out-of-hospital cardiac arrest (OHCA) survivors' ability to participate in activities of everyday life and society, including return to work. The specific aim was to evaluate potential effects of cognitive impairment.

    Methods And Results: Two hundred eighty-seven OHCA survivors included in the TTM trial (Target Temperature Management) and 119 matched control patients with ST-segment-elevation myocardial infarction participated in a follow-up 180 days post-event that included assessments of participation, return to work, emotional problems, and cognitive impairment. Read More

    Profile of Brugada Syndrome Patients Presenting with Their First Documented Arrhythmic Event. Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS).
    Heart Rhythm 2018 Jan 8. Epub 2018 Jan 8.
    Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:
    Background: Detailed information on the profile of Brugada syndrome (BrS) patients presenting their first arrhythmic event (AE) after prophylactic implantation of a cardioverter defibrillator (ICD) is limited.

    Objectives: 1) To compare clinical, electrocardiographic, electrophysiologic and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (CA) (group A) with those in whom the AE was documented after prophylactic ICD implantation (group B); 2) To characterize group B patients' profile using the Class II indications for ICD implantation established by HRS/EHRA/APHRS Expert Consensus Statement in 2013.

    Methods: A survey of 23 centers from 10 Western and 4 Asian countries enabled data collection of 678 BrS patients with AE (group A, n=426; group B, n=252). Read More

    Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records.
    PLoS One 2018 11;13(1):e0191214. Epub 2018 Jan 11.
    Farr Institute of Health Informatics Research, Institute of Health Informatics, University College London, London, United Kingdom.
    Introduction: To evaluate unmet clinical need in unselected hypertrophic cardiomyopathy (HCM) patients to determine the risk of a wide range of subsequent cardiovascular disease endpoints and safety endpoints relevant for trial design.

    Methods: Population based cohort (CALIBER, linked primary care, hospital and mortality records in England, period 1997-2010), all people diagnosed with HCM were identified and matched by age, sex and general practice with ten randomly selected people without HCM. Random-effects Poisson models were used to assess the associations between HCM and cardiovascular diseases and bleeding. Read More

    Quality Assurance Practices in Obstetric Care: A Survey of Hospitals in California.
    Obstet Gynecol 2018 Jan 9. Epub 2018 Jan 9.
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut; the Department of Pediatrics, Division of Neonatal & Developmental Medicine, Stanford University School of Medicine, Stanford, California; the Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California; and Cushing/Whitney Medical Library, Yale University, New Haven, Connecticut.
    Objective: To assess hospital practices in obstetric quality management activities and identify institutional characteristics associated with utilization of evidence-supported practices.

    Methods: Data for this study came from a statewide survey of obstetric hospitals in California regarding their organization and delivery of perinatal care. We analyzed responses from 185 hospitals that completed quality assurance sections of the survey to assess their practices in a broad spectrum of quality enhancement activities. Read More

    Trends and predictors of implantable cardioverter defibrillator implantation after sudden cardiac arrest: Insight from the national inpatient sample.
    Pacing Clin Electrophysiol 2018 Jan 9. Epub 2018 Jan 9.
    West Virginia University Heart & Vascular Institute, Morgantown, WV.
    Background: Implantable cardioverter defibrillator (ICD) has a class IA indication in survivors of sudden cardiac arrest (SCA) provided no reversible cause is identified. We sought to determine trends and predictors of ICD implant in SCA patients from a national sample of United States population.

    Methods And Results: Data was gathered from National Inpatient Sample (NIS) from January 2003 to December 2014. Read More

    Erythropoietin therapy after out-of-hospital cardiac arrest: A systematic review and meta-analysis.
    World J Cardiol 2017 Dec;9(12):830-837
    Inova Heart and Vascular Institute, Inova Medical Center, Fairfax, VA 22042, United States.
    Aim: To assess safety and efficacy of early erythropoietin (Epo) administration in patients with out-of-hospital cardiac arrest (OHCA).

    Methods: A systematic literature search was performed using PubMed, MEDLINE, EMBASE, EBSCO, CINAHL, Web of Science and Cochrane databases, of all studies published from the inception through October 10, 2016. Inclusion criteria included: (1) Adult humans with OHCA and successful sustained return of spontaneous circulation; and (2) studies including mortality/brain death, acute thrombotic events as their end points. Read More

    Improving Temporal Trends in Survival and Neurological Outcomes After Out-of-Hospital Cardiac Arrest.
    Circ Cardiovasc Qual Outcomes 2018 Jan;11(1):e003561
    From Rescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada (J.E.B., I.R.D., S.C.B., A.B., S.C., K.N.D., C.Z., L.J.M., S.L.); Division of Emergency Medicine, Department of Medicine (J.E.B., I.R.D., S.C.B., A.B., S.C., K.N.D., C.Z., L.J.M., S.L.), Institute of Medical Science (I.R.D.), Institute of Health Policy, Management and Evaluation (D.C.S., J.E.B., K.N.D., A.K., L.J.M., S.L.), Interdepartmental Division of Critical Care, Department of Medicine (D.C.S.), Division of Emergency Medicine, Department of Family and Community Medicine (S.C.), University of Toronto, ON, Canada; Department of Critical Care Medicine (D.C.S.) and Sunnybrook Center for Prehospital Medicine (S.C., M.F., P.R.V.), Sunnybrook Health Sciences Center, Toronto, ON, Canada; and Department of Emergency Medicine, Faculty of Health Sciences, Queens University, Kingston, ON, Canada (S.C.B.).
    Background: Considerable effort has gone into improving outcomes from out-of-hospital cardiac arrest (OHCA). Studies suggest that survival is improving; however, prior studies had insufficient data to pursue the relationship between markers of guideline compliance and temporal trends. The objective of the study was to evaluate trends in OHCA survival over an 8-year period that included the implementation of the 2005 and 2010 international cardiopulmonary resuscitation (CPR) guidelines. Read More

    Paediatric in-hospital cardiac arrest: Factors associated with survival and neurobehavioural outcome one year later.
    Resuscitation 2018 Jan 6;124:96-105. Epub 2018 Jan 6.
    University of Michigan, CS Mott Children's Hospital, 1540 East Hospital Drive, Ann Arbor, MI, 48109, USA.
    Objective: To investigate clinical characteristics associated with 12-month survival and neurobehavioural function among children recruited to the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital trial.

    Methods: Children (n = 329) with in-hospital cardiac arrest who received chest compressions for ≥2 min, were comatose, and required mechanical ventilation after return of circulation were included. Neurobehavioural function was assessed using the Vineland Adaptive Behaviour Scales, second edition (VABS-II) at baseline (reflecting pre-arrest status) and 12 months post-arrest. Read More

    Predicting long-term outcomes after cardiac arrest by using serum neutrophil gelatinase-associated lipocalin.
    Am J Emerg Med 2017 Dec 7. Epub 2017 Dec 7.
    Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea. Electronic address:
    Objectives: Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by various tissues in pathologic states. Previous studies reported that post-cardiac arrest serum NGAL levels correlate with short-term neurologic outcomes and survival. The aim of this study was to examine the associations between NGAL levels post-cardiac arrest and long-term outcomes and survival. Read More

    Understanding patients and spouses experiences of patient education following a cardiac event and eliciting attitudes and preferences towards incorporating cardiopulmonary resuscitation training. A qualitative study.
    J Adv Nurs 2018 Jan 9. Epub 2018 Jan 9.
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
    Aim: To gain a comprehensive perspective about the experience of patient and spousal education following an acute cardiac event. The second objective was to elicit an understanding of patient and spousal attitudes, preferences and intentions towards future cardiopulmonary resuscitation training.

    Background: Patients with cardiovascular disease require comprehensive patient and family education to ensure adequate long-term disease management. Read More

    The Day I Died.
    Ann Fam Med 2018 Jan;16(1):77-79
    Mercy Health St. Vincent Medical Center, Obstetrics & Gynecology Residency Program, Toledo, Ohio.
    When I began experiencing chest pain that was different from my usual heartburn symptoms, I denied I could possibly be having a heart attack, but chewed 4 baby aspirin just in case. Despite years of community education about the need to call 911 and seek immediate emergency care when experiencing signs and symptoms of a heart attack, more than 350,000 individuals experienced an out-of-hospital cardiac arrest in 2016. Of those, only 12% survived. Read More

    Breaking your heart-A review on CPR-related injuries.
    Am J Emerg Med 2017 Dec 28. Epub 2017 Dec 28.
    Department of Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA 19141, USA.
    Cardiopulmonary resuscitation (CPR) has been shown to increase survival after cardiac arrest, but is associated with the risk of acquired injuries to the patient. While traumatic chest wall injuries are most common, other injuries include upper airway, pulmonary and intra-abdominal injuries. This review discusses the risk factors and prevalence of CPR-related injuries. Read More

    Cisplatin-induced sudden cardiac death with hemodynamic collapse: a severe adverse drug reaction: Case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8995
    Institute of Physiology and Pharmacology.
    Rationale: Cisplatin is responsible for a significant percentage of adverse drug reactions (ADRs) in oncology setting. A great proportion of cisplatin-induced severe adverse events are difficult to foresee, and giving premedication does not always prevent the occurrence of such events.

    Patient Concerns: A 53-year-old woman with progressive T4 N0 M0 stage IV pleural mesothelioma experienced cardiac arrest with hemodynamic collapse after cisplatin and pemetrexed chemotherapy administration. Read More

    Patient, health service factors and variation in mortality following resuscitated out-of-hospital cardiac arrest in acute coronary syndrome: Analysis of the Myocardial Ischaemia National Audit Project.
    Resuscitation 2018 Jan 5;124:49-57. Epub 2018 Jan 5.
    Warwick Medical School, University of Warwick, Coventry, UK; Academic Department of Anaesthesia, Critical Care, Pain and Resuscitation, Heart of England NHS Foundation Trust, Birmingham, UK. Electronic address:
    Aims: To determine patient and health service factors associated with variation in hospital mortality among resuscitated cases of out-of-hospital cardiac arrest (OHCA) with acute coronary syndrome (ACS).

    Methods: In this cohort study, we used the Myocardial Ischaemia National Audit Project database to study outcomes in patients hospitalised with resuscitated OHCA due to ACS between 2003 and 2015 in the United Kingdom. We analysed variation in inter-hospital mortality and used hierarchical multivariable regression models to examine the association between patient and health service factors with hospital mortality. Read More

    Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest.
    Clin Exp Emerg Med 2017 Dec 30;4(4):232-237. Epub 2017 Dec 30.
    Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea.
    Objective: To investigate whether serum levels of high-density lipoprotein (HDL) and apolipoprotein A-1 (ApoA1), after the return of spontaneous circulation, can predict the neurologic outcome in patients with out-of-hospital cardiac arrest (OHCA).

    Methods: This was a retrospective observational study conducted in a single tertiary hospital intensive care unit. All adult OHCA survivors with admission lipid profiles were enrolled from March 2013 to December 2015. Read More

    Decreased coronary arteriolar response to KCa channel opener after cardioplegic arrest in diabetic patients.
    Mol Cell Biochem 2018 Jan 5. Epub 2018 Jan 5.
    Division of Cardiothoracic Surgery, Cardiovascular Research Center, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
    We have recently found that diabetes is associated with the inactivation of the calcium-activated potassium channels (KCa) in endothelial cells, which may contribute to endothelial dysfunction in diabetic patients at baseline. In the current study, we further investigated the effects of diabetes on coronary arteriolar responses to the small (SK) and intermediate (IK) KCa opener NS309 in diabetic and non-diabetic patients and correlated that data with the changes in the SK/IK protein expression/distribution in the setting of cardioplegic ischemia and reperfusion (CP) and cardiopulmonary bypass (CPB). Coronary arterioles from the harvested right atrial tissue samples from diabetic and non-diabetic patients (n = 8/group) undergoing cardiac surgery were dissected pre- and post-CP/CPB. Read More

    Extracorporeal membrane oxygenation in congenital heart disease.
    Semin Perinatol 2018 Jan 2. Epub 2018 Jan 2.
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Box 21, 225 E Chicago Ave, Chicago, IL 60610.
    This review article will discuss the indications for and outcomes of neonates with congenital heart disease who receive extracorporeal membrane oxygenation (ECMO) support. Most commonly, ECMO is used as a perioperative bridge to recovery or temporary support for those after cardiac arrest or near arrest in patients with congenital or acquired heart disease. What had historically been considered a contraindication to ECMO, is evolving and more of the sickest and most complicated babies are cared for on ECMO. Read More

    Cardiac arrest and ventricular arrhythmia in adults with Ebstein anomaly and left ventricular non-compaction.
    J Cardiol 2018 Jan 2. Epub 2018 Jan 2.
    Institute of Cardiology, Department of Congenital Heart Disease, Warsaw, Poland.
    Background: Ebstein anomaly is a complex, congenital heart defect that is associated with a variety of cardiac abnormalities. Studies found a similar sarcomere gene mutation in patients with Ebstein anomaly (EA) and patients with isolated left ventricular non-compaction (LVNC).

    Aim: We aimed to show the prevalence of LVNC and its potential relationship with severe cardiac events (VT - ventricular tachycardia, cardiac arrest) in adult patients with EA. Read More

    Unfolding Cardiac Amyloidosis - From Pathophysiology to Cure.
    Curr Med Chem 2018 Jan 4. Epub 2018 Jan 4.
    Division of Cardiology, Medical University of Graz, Graz. Austria.
    Deposition of amyloidogenic proteins leading to the formation of amyloid fibrils in the myocardium cause cardiac amyloidosis. Although any form of systemic amyloidosis can affect the heart, light-chain (AL) or transthyretin amyloidosis (ATTR) account for the majority of diagnosed cardiac amyloid deposition. The extent of cardiac disease independently predicts mortality. Read More

    The Use of ECMO for the Treatment of Refractory Cardiac Arrest or Postarrest Cardiogenic Shock Following In-Hospital Cardiac Arrest: A 10-Year Experience.
    J Intensive Care Med 2018 Jan 1:885066617751398. Epub 2018 Jan 1.
    2 Department of Critical Care Medicine, UPMC, Pittsburgh, PA, USA.
    Objectives: Extracorporeal membrane oxygenation (ECMO) has been increasingly used in the treatment of refractory cardiac arrest (extracorporeal cardiopulmonary resuscitation [ECPR]) and postarrest cardiogenic shock (PACS). Our primary objective was to determine the 1-year survival of patients who were treated with ECMO for PACS or in ECPR.

    Methods: We conducted a retrospective analysis of hospitalized patients in a tertiary care facility who underwent treatment with ECMO for ECPR or PACS. Read More

    Brain protection in aortic arch aneurysm: antegrade or retrograde?
    Gen Thorac Cardiovasc Surg 2018 Jan 3. Epub 2018 Jan 3.
    Department of Cardiothoracic and Vascular Surgery, McGovern Medical School, UT Health, UT, USA.
    During open aortic arch repair, there is an interruption of cerebral perfusion and to prevent neurological sequelae, the hypothermic circulatory arrest has been established to provide sufficient brain protection coupled with adjuncts including retrograde and antegrade cerebral perfusion. To date, brain protection during open aortic arch repair is a contested topic as to which provides superior brain protection with little evidence existing to suggest supremacy of one modality over the other. This article reviews current literature reflecting on key and emerging studies in brain protection and their associated outcomes in patients undergoing open aortic arch surgery. Read More

    Compression of a giant pseudomeningocele causing transient anoxic seizures-a case report.
    Acta Neurochir (Wien) 2018 Jan 3. Epub 2018 Jan 3.
    Department of Spinal Surgery, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
    Transient anoxic seizure upon application of pressure on a giant pseudomeningocele has never been reported in the literature; such abrupt changes in intracranial pressure due to large volume of cerebrospinal fluid (CSF) translocation, if left untreated may lead to permanent cerebral hypoxic injury and death. Here we describe a case of a 26-year-old woman who had undergone lumbar disc surgery in another unit few months ago and developed a large lump around her back. Any pressure on the lump resulted in headaches and at times episodes of seizures. Read More

    Evaluation of Physiologic Alterations during Prehospital Paramedic-Performed Rapid Sequence Intubation.
    Prehosp Emerg Care 2018 Jan 3:1-12. Epub 2018 Jan 3.
    Objective: Physiologic alterations during rapid sequence intubation (RSI) have been studied in several emergency airway management settings, but few data exist to describe physiologic alterations during prehospital RSI performed by ground-based paramedics. To address this evidence gap and provide guidance for future quality improvement initiatives in our EMS system, we collected electronic monitoring data to evaluate peri-intubation vital signs changes occurring during prehospital RSI.

    Methods: Electronic patient monitor data files from cases in which paramedic RSI was attempted were prospectively collected over a 15-month study period to supplement the standard EMS patient care documentation. Read More

    Uhl's anomaly: A one and a half ventricular repair in a patient presenting with cardiac arrest.
    J Saudi Heart Assoc 2018 Jan 7;30(1):52-54. Epub 2017 Apr 7.
    Division of Cardiology, Children's National Medical Center, Washington, DC, USAbUSA.
    Uhl's anomaly, first reported in 1952, is an extremely rare congenital cardiac defect characterized by partial or complete loss of the right ventricular myocardium and unknown etiology. Fewer than 100 cases have been described. The response to medical management is poor and there is no known ideal surgical approach or timing for treatment. Read More

    Safety and Improved Clinical Outcomes in Patients Treated With New Equine-Derived Heptavalent Botulinum Antitoxin.
    Clin Infect Dis 2017 Dec;66(suppl_1):S57-S64
    Enteric Diseases Epidemiology Branch, Division of Foodborne, Waterborne, and Environmental Diseases (DFWED), Centers for Disease Control and Prevention, Atlanta, Georgia.
    Background: Botulism is a rare, life-threatening paralytic illness. Equine-derived heptavalent botulinum antitoxin (HBAT), the only currently available treatment for noninfant botulism in the United States, was licensed in 2013. No reports have systematically examined safety and clinical benefit of HBAT among botulism patients. Read More

    Buckberg versus Calafiore Cardioplegia in Patients with Acute Coronary Syndromes.
    Thorac Cardiovasc Surg 2017 Dec 31. Epub 2017 Dec 31.
    Department of Cardiothoracic Surgery, Heart Center of the University Hospital of Cologne, Cologne, Germany.
    Background:  Choice of cardioplegic solution plays a pivotal role in special subgroups of patients referred for on-pump cardiac surgery. This retrospective analysis aimed to assess the impact of intermittent warm (Calafiore, Cala) versus intermittent cold blood cardioplegia (Buckberg, Buck) in patients referred to coronary artery bypass graft (CABG) surgery due to acute coronary syndromes (ACS).

    Methods:  From 2008 to 2015, all consecutive patients undergoing urgent on-pump CABG surgery due to ACS (n = 950) were retrospectively analyzed. Read More

    Outcomes and Predictors of Mortality After Mitral Valve Surgery in High-Risk Elderly Patients: The Heidelberg Experience.
    Med Sci Monit 2017 Dec 31;23:6193-6200. Epub 2017 Dec 31.
    Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg, Germany.
    BACKGROUND Overall, life expectancy at the age of 80 has significantly increased in the industrialized world and the proportion of this age class undergoing cardiac surgery has also grown. In this context, we have analyzed a contemporary series of octogenarians undergoing mitral valve surgery at our institution. MATERIAL AND METHODS We performed a retrospective analysis of 138 consecutive octogenarians receiving mitral valve surgery between January 2006 and April 2017. Read More

    Cannabinoids and Symptomatic Bradycardia.
    Am J Med Sci 2018 Jan 22;355(1):3-5. Epub 2017 Mar 22.
    Division of Cardiovascular Diseases. Electronic address:
    Cannabinoids, the bioactive components of marijuana, have adverse cardiovascular consequences, including symptomatic sinus bradycardia, sinus arrest and ventricular asystole. Physicians should be aware of these deleterious consequences which can appear in otherwise healthy persons who are chronic marijuana users. Read More

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