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    [Coronary artery disease : Interventional and operative therapeutic options after cardiac arrest].
    Herz 2017 Feb 22. Epub 2017 Feb 22.
    I. Medizinische Klinik, Universitätsmedizin Mannheim (UMM), Medizinische Fakultät Mannheim, Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.
    Coronary artery disease (CAD) represents a common structural cause for developing cardiac arrest in older patients, whereas in young adults cardiac arrest is more often caused by cardiomyopathies and cardiac channelopathies. A structural heart disease is known in almost 50% of patients prior to cardiac arrest. The present review outlines current interventional and operative therapeutic options for patients surviving cardiac arrest. Read More

    Alterations in cardiac autonomic control in spinal cord injury.
    Auton Neurosci 2017 Feb 15. Epub 2017 Feb 15.
    International Collaboration On Repair Discoveries (ICORD), Autonomic Research Unit, ICORD-BSCC, UBC, 818 West 10th Avenue, V5Z 1M9 Vancouver, BC, Canada; Spinal Cord Program, GF Strong Rehabilitation Centre, University of British Columbia, 4255 Laurel St., V5Z 2G9 Vancouver, BC, Canada; Department of Physical Medicine and Rehabilitation, University of Western Ontario, London, ON, Canada. Electronic address:
    A spinal cord injury (SCI) interferes with the autonomic nervous system (ANS). The effect on the cardiovascular system will depend on the extent of damage to the spinal/central component of ANS. The cardiac changes are caused by loss of supraspinal sympathetic control and relatively increased parasympathetic cardiac control. Read More

    A great imitator in adult cardiology practice: congenitally corrected transposition of the great arteries.
    Congenit Heart Dis 2017 Feb 22. Epub 2017 Feb 22.
    Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, Milwaukee, Wisconsin, USA.
    Introduction: Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital disease that frequently remains undiagnosed until adulthood, especially when there is an absence of other congenital anomalies. Adults with ccTGA may remain asymptomatic and their diagnosis could be missed on initial evaluation, or it could be diagnosed incidentally as an evaluation of murmur. We aim to report the different presentations of ccTGA in eight adult patients and review the key features required to suspect the diagnosis during an initial visit. Read More

    [A patient with severe digoxin toxicity].
    Ned Tijdschr Geneeskd 2017 ;161(0):D839
    Tergooi, Hilversum.
    Background: Digoxin is a cardiac glycoside that is frequently prescribed in atrial fibrillation and heart failure. Symptoms such as nausea, hyperkalaemia, cardiac arrhythmias and cardiac arrest are seen in digoxin toxicity. The treatment focuses on reduction of digoxin absorption, prevention of hypokalaemia and hyperkalaemia, treatment of symptoms and, in severe toxicity, administration of digoxin antibodies. Read More

    Impact of Early Vasopressor Administration on Neurological Outcomes after Prolonged Out-of-Hospital Cardiac Arrest.
    Prehosp Disaster Med 2017 Feb 22:1-8. Epub 2017 Feb 22.
    2Center for Educational Excellence,Duke Clinical Research Institute,Durham,North CarolinaUSA.
    Introduction Vasopressors are associated with return of spontaneous circulation (ROSC), but no long-term benefit has been demonstrated in randomized trials. However, these trials did not control for the timing of vasopressor administration which may influence outcomes. Consequently, the objective of this study was to develop a model describing the likelihood of favorable neurological outcome (cerebral performance category [CPC] 1 or 2) as a function of the public safety answering point call receipt (PSAP)-to-pressor-interval (PPI) in prolonged out-of-hospital cardiac arrest. Read More

    Corrigendum to "Long-term clinical outcomes and predictors for survivors of out-of-hospital cardiac arrest" [Resuscitation 112 (2016) 59-64].
    Resuscitation 2017 Feb 18. Epub 2017 Feb 18.
    Department of Medicine, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.

    Significance of new Q waves and their location in postoperative ECGs after elective on-pump cardiac surgery: An observational cohort study.
    Eur J Anaesthesiol 2017 Feb 17. Epub 2017 Feb 17.
    From the Department for Anesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy (EM, DB, JF, EES, GALLB); Division of Cardiac Surgery, Basel University Hospital (MG); and Basel University Medical School, Basel, Switzerland (MDS, MF).
    Background: The clinical significance of new pathological Q waves after on-pump cardiac surgery is uncertain.

    Objectives: To determine whether or not either the occurrence per se or the location of new pathological Q waves after on-pump cardiac surgery is associated with 12-month, all-cause mortality and/or major adverse cardiac events (MACEs).

    Design: Observational cohort study. Read More

    The influence of targeted temperature management on the pharmacokinetics of drugs administered during and after cardiac arrest: a systematic review.
    Acta Clin Belg 2017 Feb 21:1-7. Epub 2017 Feb 21.
    a Faculty of Medicine and Health Sciences , Ghent University , Ghent , Belgium.
    Objective: Pharmacokinetic parameters of drugs are widely investigated under normothermic conditions and normal hemodynamic parameters. The European Resuscitation Council recommends the use of targeted temperature management (TTM) with a target temperature of 34 °C in cardiac arrest (CA) patients. The aim of this literature review is to investigate the influence of CA combined with TTM on the pharmacokinetics of drugs. Read More

    Synchronous cardiocerebral infarction in the era of endovascular therapy: which to treat first?
    J Thromb Thrombolysis 2017 Feb 20. Epub 2017 Feb 20.
    Division of Neurology, Department of Medicine, National University Health System, 1 E Kent Ridge Road, Singapore, 119228, Singapore.
    A cardiocerebral ischemic attack (CCI) or a concurrent acute ischemic stroke (AIS) and myocardial infarction (AMI) is a severe event with no clear recommendations for ideal management because of the rarity of the scenario. The narrow time window for treatment and complexity of the treatment decision puts immense pressure on the treating physician. We evaluated this challenging situation at our tertiary center. Read More

    Targeted temperature management after intraoperative cardiac arrest: a multicenter retrospective study.
    Intensive Care Med 2017 Feb 20. Epub 2017 Feb 20.
    Medical-Surgical Intensive Care Unit, Intensive Care Department, Centre Hospitalier de Versailles-Site André Mignot, 177 rue de Versailles, 78150, Le Chesnay Cedex, France.
    Purpose: Few outcome data are available about temperature management after intraoperative cardiac arrest (IOCA). We describe targeted temperature management (TTM) (32-34 °C) modalities, adverse events, and association with 1-year functional outcome in patients with IOCA.

    Methods: Patients admitted to 11 ICUs after IOCA in 2008-2013 were studied retrospectively. Read More

    Health status and psychological distress among in-hospital cardiac arrest survivors in relation to gender.
    Resuscitation 2017 Feb 17. Epub 2017 Feb 17.
    Department of Health and Caring Science, Linnaeus University, Kalmar, Sweden; Department of Health Care Science, Ersta Sköndal University College, Stockholm, Sweden; Kalmar County Hospital, Kalmar, Sweden.
    Aim: To describe health status and psychological distress among in-hospital cardiac arrest (IHCA) survivors in relation to gender.

    Methods: This national register study consists of data from follow-up registration of IHCA survivors 3-6 months post cardiac arrest (CA) in Sweden. A questionnaire was sent to the survivors, including measurements of health status (EQ-5D-5L) and psychological distress (HADS). Read More

    Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose.
    Eur J Pharmacol 2017 Feb 16. Epub 2017 Feb 16.
    Chinese Herb Medicine Division, The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, P. R., China. Electronic address:
    Caffeine overdose death is due to cardiac arrest, but its mechanism has not been explored in detail. In this study, our data showed that caffeine significantly prolonged the heart rate-corrected QT interval (QTc) of rabbits in vivo (P < 0.05; n = 7). Read More

    The Cardiac Electrophysiology of Patients with Spinal Cord Injury.
    Heart Rhythm 2017 Feb 12. Epub 2017 Feb 12.
    Associate Professor of Medicine, Program Director Clinical Electrophysiology Fellowship. Emory University Hospital, Cardiac Electrophysiology Department. 1364 Clifton Road, Suite F424, Atlanta, GA, 30322.
    Spinal cord injury (SCI) is a clinical syndrome encountered frequently in trauma centers and is accompanied by both acute and chronic heart rhythm abnormalities. The injury is characterized by sympathetic nervous system (SNS) impairment with preservation of parasympathetic output via the vagus nerve. Severe bradycardia in the form of life-threatening sinus arrest or complete heart block may be observed in the acute recovery phase. Read More

    High School Cardiac Emergency Response Plans and Sudden Cardiac Death in the Young.
    Prehosp Disaster Med 2017 Feb 20:1-4. Epub 2017 Feb 20.
    1Division of Pediatric Cardiology,Department of Pediatrics and Communicable Diseases,University of Michigan Congenital Heart Center,C.S. Mott Children's Hospital,Ann Arbor,MichiganUSA.
    Introduction Sudden cardiac death (SCD) is responsible for 5%-10% of all deaths among children 5-19 years-of-age. The incidence of SCD in youth in Michigan (USA) and nationwide is higher in racial/ethnic minorities and in certain geographic areas. School cardiac emergency response plans (CERPs) increase survival after cardiac arrest. Read More

    Rapid response team diagnoses: frequencies and related hospital mortality.
    Crit Care Resusc 2017 Mar;19(1):71-80
    Department of Critical Care Medicine, St Vincent's Hospital, Melbourne, VIC, Australia.
    Objectives: To describe the frequency and hospital mortality of problems (diagnoses) encountered by a rapid response team (RRT), and to identify the most common diagnoses for RRT triggers and for treating units.

    Design: For each RRT event in 2015 at a tertiary hospital for adults, we chose the diagnosis that best explained the RRT event from a pre-defined list after reviewing relevant test results and clinical notes.

    Results: There were 937 RRT events during 700 admissions and there were 58 different RRT diagnoses in 11 diagnosis groups. Read More

    Evaluation of Timing and Route of Epinephrine in a Neonatal Model of Asphyxial Arrest.
    J Am Heart Assoc 2017 Feb 18;6(2). Epub 2017 Feb 18.
    Pediatrics, SUNY University at Buffalo, NY.
    Background: Epinephrine administered by low umbilical venous catheter (UVC) or endotracheal tube (ETT) is indicated in neonates who fail to respond to positive pressure ventilation and chest compressions at birth. Pharmacokinetics of ETT epinephrine via fluid-filled lungs or UVC epinephrine in the presence of fetal shunts is unknown. We hypothesized that epinephrine administered by ETT or low UVC results in plasma epinephrine concentrations and rates of return of spontaneous circulation (ROSC) similar to right atrial (RA) epinephrine. Read More

    Catheter-directed, ultrasound-assisted thrombolysis is a safe and effective treatment for pulmonary embolism, even in high-risk patients.
    J Vasc Surg Venous Lymphat Disord 2017 Mar 12;5(2):165-170. Epub 2017 Jan 12.
    The Cardiovascular Care Group, Westfield, NJ. Electronic address:
    Objective: We sought to assess the early success and safety of catheter-directed, ultrasound-assisted (CDUA) thrombolysis for acute pulmonary embolism (PE) in patients deemed to be "high risk" for thrombolytic therapy.

    Methods: A retrospective evaluation of patients who underwent CDUA pulmonary thrombolysis in our practice during 39 months is reported. There were 91 patients considered, all of whom presented with acute PE as diagnosed by computed tomography angiography. Read More

    Interventional Treatment of Pulmonary Embolism.
    Circ Cardiovasc Interv 2017 Feb;10(2)
    From the Cardiology Division (D.M.D., K.R.) and Vascular Medicine (K.R.), Massachusetts General Hospital, Boston; and Cardiovascular Medicine Division, Hospital of the University of Pennsylvania, Philadelphia (J.G.).
    Pulmonary embolism (PE) is a serious and prevalent cause of vascular disease. Nevertheless, optimal treatment for many phenotypes of PE remains uncertain. Treating PE requires appropriate risk stratification as a first step. Read More

    Multiple myocardial abscesses secondary to late stent infection.
    Cardiovasc Pathol 2017 Feb 2;28:1-2. Epub 2017 Feb 2.
    Department of Pulmonary and Critical care Medicine, Rochester General Hospital, Rochester, NY.
    A 53-year-old woman presented to our hospital with dizziness and low-grade fever. She underwent percutaneous coronary intervention to the obtuse marginal artery with a drug-eluting stent 20 months prior to this presentation. Physical examination was remarkable for bradycardia. Read More

    Hypertrophic Cardiomyopathy With Left Ventricular Apical Aneurysm: Implications for Risk Stratification and Management.
    J Am Coll Cardiol 2017 Feb;69(7):761-773
    Hypertrophic Cardiomyopathy Institute, Division of Cardiology, Tufts Medical Center, Boston, Massachusetts. Electronic address:
    Background: A previously under-recognized subset of hypertrophic cardiomyopathy (HCM) patients with left ventricular (LV) apical aneurysms is being identified with increasing frequency. However, risks associated with this subgroup are unknown.

    Objectives: The authors aimed to clarify clinical course and prognosis of a large cohort of HCM patients with LV apical aneurysms over long-term follow-up. Read More

    Clinical Profile of Cardiac Arrhythmias in Children Attending the Out Patient Department of a Tertiary Paediatric Care Centre in Chennai.
    J Clin Diagn Res 2016 Dec 1;10(12):SC06-SC08. Epub 2016 Dec 1.
    Director, Department of Pediatrics, Mehta Hospitals , Nungamabakkam, Chennai, Tamil Nadu, India .
    Introduction: The presentation of symptoms of paediatric arrhythmias vary depending on the age and underlying heart disease. Physical examination of children with important arrhythmias may be entirely normal.

    Aim: Aim is to study the characteristics of cardiac arrhythmias in paediatric patients in a tertiary paediatric care centre in Chennai, India. Read More

    Haemodynamic changes to a midazolam-fentanyl-rocuronium protocol for pre-hospital anaesthesia following return of spontaneous circulation after cardiac arrest.
    Anaesthesia 2017 Feb 15. Epub 2017 Feb 15.
    Kent Surrey Sussex Air Ambulance Trust, Marden, Kent, UK.
    Following the return of spontaneous circulation after out-of-hospital cardiac arrest, neurological dysfunction, airway or ventilatory compromise can impede transport to early percutaneous coronary intervention, necessitating pre-hospital or emergency department anaesthesia to facilitate this procedure. There are no published reports of the ideal induction agents in these patients. We sought to describe haemodynamic changes associated with induction of anaesthesia using a midazolam (0. Read More

    [Remodeling of the aging heart : Sinus node dysfunction and atrial fibrillation].
    Herzschrittmacherther Elektrophysiol 2017 Feb 15. Epub 2017 Feb 15.
    Institut für Physiologie, Abteilung II, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 7, 79104, Freiburg, Deutschland.
    The incidence of both sinus node dysfunction (SND) and atrial fibrillation (AF) increases with age. SND and AF frequently coexist. Likewise, they are often associated with cardiovascular diseases. Read More

    Thoracoabdominal aortic replacement for Crawford extent II aneurysm after thoracic endovascular aortic repair.
    J Thorac Dis 2017 Jan;9(1):64-69
    Department of Cardiovascular Surgery, Beijing Aortic Disease Centre, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Engineering Research Centre for Vascular Prostheses, Beijing 100029, China.
    Background: The surgical treatment of Crawford extent II aneurysms after thoracic endovascular aortic repair (TEVAR) remains challenging, because of the need to remove the failed endograft and the complexity of the aortic reconstruction. We retrospectively reviewed our experience with surgical management of Crawford extent II aneurysms after TEVAR using thoracoabdominal aortic replacement (TAAR).

    Methods: Eleven patients (10 males, 1 female) with Crawford extent II aneurysm after TEVAR were treated with TAAR between August 2012 and May 2015. Read More

    Identification of pathogenic variants in genes related to channelopathy and cardiomyopathy in Korean sudden cardiac arrest survivors.
    J Hum Genet 2017 Feb 16. Epub 2017 Feb 16.
    Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Pathogenic variants in genes related to channelopathy and cardiomyopathy are the most common cause of sudden unexplained cardiac death. However, few reports have investigated the frequency and/or spectrum of pathogenic variants in these genes in Korean sudden cardiac arrest survivors. This study aimed to investigate the causative genetic variants of cardiac-associated genes in Korean sudden cardiac arrest survivors. Read More

    Targets and End Points in Cardiac Autonomic Denervation Procedures.
    Circ Arrhythm Electrophysiol 2017 Feb;10(2):e004638
    From the Unidade Clínica de Arritmia, Heart Institute, University of São Paulo Medical School, Brazil.
    Background: Autonomic denervation is an alternative approach for patients with symptomatic bradycardia. No consensus exists on the critical targets and end points of the procedure. The aim of this study was to identify immediate end points and critical atrial regions responsible for vagal denervation. Read More

    Out-of-hospital cardiac arrest (OHCA) attended by mobile emergency teams with a physician on board. Results of the Spanish OHCA Registry (OSHCAR).
    Resuscitation 2017 Feb 13;113:90-95. Epub 2017 Feb 13.
    Hospital el Toyo, Almería, Spain.
    Most survival outcomes in out-of-hospital cardiac arrest (OHCA) are provided by emergency medical services (EMS) without a doctor on board. Our objective was to determine such outcomes in a whole country with public physician-led EMS.

    Methods: We analyzed data from a nationwide prospective registry of OHCA cases attended by 19 public EMS in Spain, covering the period from 1-October 2013 to 30-October 2014. Read More

    A Sudden Change of Heart: A Case of Rapidly Reversed Stress Cardiomyopathy in a Critically Ill Patient.
    Cardiol Res 2016 Jun 24;7(3):119-121. Epub 2016 Jun 24.
    Department of Medicine and Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA.
    We report the case of a 79-year-old woman who presented to our hospital for elective removal of an infratentorial meningioma and suffered a periprocedural cardiac arrest. Shortly after uncomplicated induction of anesthesia prior to the surgery, the patient became hypotensive and bradycardic, culminating ultimately in a cardiac arrest with pulseless electrical activity. Return of spontaneous circulation occurred within 90 seconds of arrest, but the patient remained dependent on maximal doses of epinephrine and dopamine for hemodynamic support. Read More

    Incidence and Survival After In-Hospital Cardiopulmonary Resuscitation in Nonelderly Adults: US Experience, 2007 to 2012.
    Circ Cardiovasc Qual Outcomes 2017 Feb;10(2)
    From the Division of Cardiology, Detroit Medical Center, Wayne State University School of Medicine, MI (S.M.-R., A.B., E.A., K.J., L.A., C.L.G.); and Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B., M.R.).
    Background: Survival trends after in-hospital cardiopulmonary resuscitation (ICPR) for cardiac arrest in nonelderly adults is not well known. Influence of cardiopulmonary resuscitation guidelines on nationwide survival after ICPR is yet to be well elucidated.

    Methods And Results: We examined survival trends and factors associated with survival after ICPR in nonelderly adults aged 18 to 64 years, using Healthcare Utilization Project Nationwide Inpatient Sample Database from 2007 through 2012 in the United States. Read More

    Coexistence of Subdural Hematoma and a Rare Cardiopathy in an Infant: Etiological and French Medicolegal Discussion.
    J Forensic Sci 2017 Feb 10. Epub 2017 Feb 10.
    Department of Forensic Pathology, Assistance Publique-Hôpitaux de Marseille (APHM), CHU Timone, 13385, Marseille Cedex 5, France.
    During legal proceedings following the unexpected death of an infant, the magistrate calls on an expert to clarify the causes of death and to decide on the course to be taken. A report was made following the death of a 7-month-old baby girl after recovery from cardiac arrest when investigations of the cause revealed a subdural hematoma (SDH). We discuss the interconnection of these two entities and their role in the lethal process. Read More

    Clinical Question: In congestive heart failure patients with preserved ejection fraction, does spironolactone improve cardiac outcomes?
    J Okla State Med Assoc 2016 Sep;109(9):437-438
    St. Anthony Family Medicine Residency, Oklahoma City, OK.
    Clinical Question: In congestive heart failure patients with preserved ejection fraction, does spironolactone improve cardiac outcomes?

    Answer: No. A randomized controlled trial of patients with heart failure and an ejection fraction > 45% showed that spironolactone did not significantly reduce the incidence of the primary composite outcome of death from cardiovascular causes, aborted cardiac arrest, or hospitalization for the management of heart failure.

    Level Of Evidence For The Answer: A. Read More

    Perioperative anesthetic management for renal cell carcinoma with vena caval thrombus extending into the right atrium: case series.
    J Clin Anesth 2017 Feb 17;36:39-46. Epub 2016 Nov 17.
    Department of Anesthesia, Indiana University School of Medicine, Fesler Hall Room 204, 1130 West Michigan St, Indianapolis, IN, 46202-5115.
    Renal cell carcinoma has a tendency for vascular invasion and may extend into the inferior vena cava and even into the right-sided cardiac chambers. It has been reported that nephrectomy with thrombectomy can provide immediate palliation of symptoms with 5-year survival rates of up to 72% in the absence of nodal or distant metastasis. The location of the tumor dictates the anesthetic and surgical approach, as extension into the heart often necessitates cardiac surgical involvement. Read More

    Identification of TAZ mutations in pediatric patients with cardiomyopathy by targeted next-generation sequencing in a Chinese cohort.
    Orphanet J Rare Dis 2017 Feb 10;12(1):26. Epub 2017 Feb 10.
    Department of Cardiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Pudong, Shanghai, 200127, People's Republic of China.
    Background: Barth syndrome (BTHS) is a rare X-linked recessive disease characterized by cardiomyopathy, neutropenia, skeletal myopathy and growth delay. Early diagnosis and appropriate treatment may improve the prognosis of this disease. The purpose of this study is to determine the role of targeted next-generation sequencing (NGS) in the early diagnosis of BTHS in children with cardiomyopathy. Read More

    An alternative technique for Fontan completion in patients with widely separated connections of the inferior systemic veins to the atrial mass.
    Cardiol Young 2016 Aug 30:1-4. Epub 2016 Aug 30.
    3Pediatric Cardiology Clinic of Pediatrics,University of Pavia,Pavia,Italy.
    Several surgical approaches for completion of a total cavopulmonary connection have been established for patients with anomalies of systemic venous connection in association with a functionally univentricular heart. We report an alternative technique designed to address the problem of widely separated inferior systemic veins, in which two extracardiac conduits were used. This technique was performed on three patients and yielded excellent short-term results, allowing us to operate on a beating heart with no need for cardioplegic arrest and aortic cross-clamping. Read More

    Takotsubo Syndrome After Cardiopulmonary Resuscitation During Emergency Cesarean Delivery.
    Obstet Gynecol 2017 Mar;129(3):521-524
    Departments of Obstetrics and Gynecology and Cardiology, Klinikum Kempten Oberallgäu, Kempten, Germany.
    Background: Takotsubo syndrome is a rare, stress-related, and reversible form of acute heart failure primarily affecting postmenopausal women. It is characterized by left ventricular dysfunction with a classic apical and midventricular wall motion abnormality (apical ballooning).

    Case: A 28-year-old woman, gravida 2 para 1, at 30 4/7 weeks of gestation was admitted with fetal bradycardia, a fully dilated cervix, and breech presentation. Read More

    Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation.
    Mol Cell Biochem 2017 Feb 7. Epub 2017 Feb 7.
    Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), LVA, CIF, CCS, Florianópolis,, SC, 88040-900, Brazil.
    Cardenolides are cardiac glycosides, mostly obtained from natural sources. They are well known for their inhibitory action on the Na,K-ATPase, an effect that regulates cardiovascular alterations such as congestive heart failure and atrial arrhythmias. In recent years, they have also sparked new interest in their anticancer potential. Read More

    Massive left atrial calcification: a case report and review of the literature.
    Gen Thorac Cardiovasc Surg 2017 Feb 7. Epub 2017 Feb 7.
    Division of Cardiothoracic Surgery, Warren Alpert School of Medicine, Brown University, Rhode Island, USA.
    Left atrial (LA) calcification is mostly observed in patients with rheumatic mitral valve (MV) diseases who underwent surgical treatment. We report a case of LA calcification in a 69-year-old woman presented with dyspnea and cyanosis. Admission electrocardiogram showed atrial fibrillation and biventricular hypertrophy. Read More

    Good neurological outcome after accidental hyopthermia presenting with asytole.
    Anaesthesist 2017 Feb 7. Epub 2017 Feb 7.
    Abteilung für Anästhesiologie, Schmerztherapie und Rettungsmedizin, Ospidal - Gesundheitszentrum Unterengadin, Via Ospidal, 7550, Scuol, Switzerland.
    A 43-year-old woman became exhausted and fainted on descent at 1127 MAMSL altitude and snowfall. A rescue team diagnosed asystole. With manual cardiopulmonary resuscitation (CPR) she was transported to the next extracorporeal life support (ECLS) center. Read More

    Association of Implementation of Practice Standards for Electrocardiographic Monitoring With Nurses' Knowledge, Quality of Care, and Patient Outcomes: Findings From the Practical Use of the Latest Standards of Electrocardiography (PULSE) Trial.
    Circ Cardiovasc Qual Outcomes 2017 Feb;10(2)
    From the School of Nursing, Yale University, West Haven, CT (M.F.); Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami (K.P.F.); Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD (K.E.S.); Yale Center for Clinical Investigation, School of Medicine, Yale University, New Haven, CT (J.L.M.); Western Connecticut Medical Group, Danbury (C.G.W.); and Department of Physiological Nursing, School of Nursing, University of California San Francisco (B.J.D.).
    Background: Although continuous electrocardiographic (ECG) monitoring is ubiquitous in hospitals, monitoring practices are inconsistent. We evaluated implementation of American Heart Association practice standards for ECG monitoring on nurses' knowledge, quality of care, and patient outcomes.

    Methods And Results: The PULSE (Practical Use of the Latest Standards of Electrocardiography) Trial was a 6-year multisite randomized clinical trial with crossover that took place in 65 cardiac units in 17 hospitals. Read More

    A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial.
    Resuscitation 2017 Feb 4. Epub 2017 Feb 4.
    Cardiovascular Division, The Rayne Institute BHF Centre of Research Excellence, King's College London, St. Thomas' Hospital, London, UK. Electronic address:
    Background: Wide variation exists in inter-hospital survival from out-of-hospital cardiac arrest (OHCA). Regionalisation of care into cardiac arrest centres (CAC) may improve this. We report a pilot randomised trial of expedited transfer to a CAC following OHCA without ST-elevation. Read More

    Emergency Medicine Myths: Epinephrine in Cardiac Arrest.
    J Emerg Med 2017 Feb 4. Epub 2017 Feb 4.
    Department of Emergency Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.
    Background: Sudden cardiac arrest accounts for approximately 15% of deaths in developed nations, with poor survival rate. The American Heart Association states that epinephrine is reasonable for patients with cardiac arrest, though the literature behind its use is not strong.

    Objective: To review the evidence behind epinephrine for cardiac arrest. Read More

    Echocardiography for patients undergoing extracorporeal cardiopulmonary resuscitation: a primer for intensive care physicians.
    J Intensive Care 2017 2;5:15. Epub 2017 Feb 2.
    0000 0004 1759 700Xgrid.13402.34Department of Emergency Medicine, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, No 3, East Qingchun Road, Hangzhou, 310016 Zhejiang Province China.
    Echocardiography is an invaluable tool in the management of patients with extracorporeal cardiopulmonary resuscitation (ECPR) and subsequent extracorporeal membrane oxygenation (ECMO) support and weaning. At the very beginning, echocardiography can identify the etiology of cardiac arrest, such as massive pulmonary embolism and cardiac tamponade. Eliminating these culprits saves life and may avoid the initiation of extracorporeal cardiopulmonary resuscitation. Read More

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