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    Takotsubo cardiomyopathy after intravenous epinephrine administration following cardiac arrest provoked by pneumoperitoneum - a case report.
    Pol Merkur Lekarski 2017 Apr;42(250):165-169
    Józef Struś Hospital, Poznań, Poland: Department of General and Colorectal Surgery.
    In stress-induced takotsubo cardiomyopathy (TC) high levels of catecholamines, including epinephrine, may be detected in blood. On the other hand, administration of exogenous epinephrine may occasionally result in TC.

    A Case Report: The authors describe a case of a 58-year-old, otherwise healthy female, with TC which occurred after intravenous injection of 1 mg of epinephrine against cardiac arrest provoked by pneumoperitoneum performed before planned laparoscopic cholecystectomy. Read More

    C-GRApH: A Validated Scoring System for Early Stratification of Neurologic Outcome After Out-of-Hospital Cardiac Arrest Treated With Targeted Temperature Management.
    J Am Heart Assoc 2017 May 20;6(5). Epub 2017 May 20.
    Department of Cardiovascular Medicine, University of Virginia, Charlottesville, VA
    Background: Out-of-hospital cardiac arrest (OHCA) results in significant morbidity and mortality, primarily from neurologic injury. Predicting neurologic outcome early post-OHCA remains difficult in patients receiving targeted temperature management.

    Methods And Results: Retrospective analysis was performed on consecutive OHCA patients receiving targeted temperature management (32-34°C) for 24 hours at a tertiary-care center from 2008 to 2012 (development cohort, n=122). Read More

    Protective roles of bioactive peptides during ischemia-reperfusion injury: From bench to bedside.
    Life Sci 2017 May 17. Epub 2017 May 17.
    Henan University School of Basic Medical Sciences, Kaifeng 475004, Henan, China; Institute of Environmental Medicine, Henan University, Kaifeng 475004, Henan, China. Electronic address:
    Ischemia-reperfusion (I/R) is a well-known pathological condition which may lead to disability and mortality. I/R injury remains an unresolved and complicated situation in a number of clinical conditions, such as cardiac arrest with successful reanimation, as well as ischemic events in brain and heart. Peptides have many attractive advantages which make them suitable candidate drugs in treating I/R injury, such as low toxicity and immunogenicity, good solubility property, distinct tissue distribution pattern, and favorable pharmacokinetic profile. Read More

    Slow ventricular tachycardia in a 91-year-old man with implantable cardioverter-defibrillator and acute respiratory failure.
    Am J Emerg Med 2017 May 11. Epub 2017 May 11.
    Cardiology and Coronary Intensive Care Unit, "San Giuseppe Moscati" Hospital, via Contrada Amoretta, 83100 Avellino, Italy.
    Slow ventricular tachycardia (VT) in patients with devices such as an implantable cardioverter - defibrillator (ICD) is more common than in the rest of the population. The incidence in elderly patients with an ICD remains largely unknown. In younger patients, slow VT is generally asymptomatic or associated with limited clinical relevance. Read More

    Evaluation of conventional and frozen elephant trunk techniques on spinal cord blood flow in an animal model†.
    Eur J Cardiothorac Surg 2017 May 18. Epub 2017 May 18.
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany.
    Objectives: The treatment of patients with extensive thoracic aortic disease involving the arch and descending aorta is often performed using the frozen elephant trunk technique (FET). Spinal cord blood flow (SCBF) in cervical, thoracic and lumbar sections prior, during and after aortic arch surgery were compared in conventional elephant trunk (cET) and FET technique in a pig model.

    Methods: German Landrace pigs (75-85 kg) underwent aortic arch surgery using the FET ( n  = 8) or cET ( n  = 8) techniques. Read More

    The Girona Territori Cardioprotegit Project: Performance Evaluation of Public Defibrillators.
    Rev Esp Cardiol (Engl Ed) 2017 May 15. Epub 2017 May 15.
    Servicio de Cardiología, Hospital Universitari Dr. Josep Trueta, Girona, Spain; Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Girona, Girona, Spain; Centro de Genética Cardiovascular, Instituto de investigación biomédica de Girona (IDIBGI), Girona, Spain.
    Introduction And Objectives: In recent years, public access defibrillation programs have exponentially increased the availability of automatic external defibrillators (AED) in public spaces but there are no data on their performance in our setting. We conducted a descriptive analysis of the performance of AED since the launch of a public defibrillation program in our region.

    Methods: A retrospective analysis was conducted of electrocardiographic tracings and the performance of AED in a public defibrillation program from June 2011 to June 2015 in the province of Girona, Spain. Read More

    Risk factors for in-hospital shunt thrombosis and mortality in patients weighing less than 3 kg with functionally univentricular heart undergoing a modified Blalock-Taussig shunt†.
    Interact Cardiovasc Thorac Surg 2017 May 17. Epub 2017 May 17.
    Division of Cardiothoracic Surgery, Faculty of Medicine, Department of Surgery, Prince of Songkla University, Songkhla, Thailand.
    Objectives: To determine the association between several perioperative variables and in-hospital shunt thrombosis and mortality in patients weighing less than 3 kg with functional univentricular heart (UVH) who underwent modified Blalock-Taussig shunt.

    Methods: Between January 2006 and February 2016, 85 patients who weighed less than 3 kg with functional UVH and underwent modified Blalock-Taussig shunt were reviewed. In-hospital shunt thrombosis and mortality were the primary outcomes. Read More

    Lower Aorto-Iliac Bifurcation Position and Incident Cardiovascular Disease: A Multi-Ethnic Study of Atherosclerosis (MESA).
    Aorta (Stamford) 2016 Oct 1;4(5):156-161. Epub 2016 Oct 1.
    Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California, USA.
    Background: With increasing age, a downward shift of the aorto-iliac bifurcation relative to the lumbar spine occurs. A lower bifurcation position is an independent marker for adverse vascular aging and is associated with increased burden of cardiovascular disease (CVD) risk factors; however, the associations between lower bifurcation position and CVD events remain unknown.

    Methods: Abdominal computed tomography scans were used to measure the aorto-iliac bifurcation distance (AIBD, distance from the aorto-iliac bifurcation to the L5/S1 disc space). Read More

    Transient Left Bundle Branch Block due to Severe Hyperkalemia.
    Cardiol Res 2017 Apr 3;8(2):77-80. Epub 2017 May 3.
    Department of Medicine, Bronx Lebanon Hospital Center, Bronx, NY 10457, USA.
    Hyperkalemia is a potentially life-threatening electrolyte imbalance that can lead to sudden death from cardiac arrhythmias and asystole. We present a case of transient left bundle branch block pattern on an electrocardiogram (ECG) secondary to hyperkalemia in a patient with history of end-stage renal disease. A 52-year-old man presented to the emergency room (ER) with chief complaints of weakness and lethargy after missing his regularly scheduled session of hemodialysis. Read More

    ISMP Adverse Drug Reactions: Pregabalin-Induced Stuttering Nitroglycerine-Induced Bradycardia Progressing to Asystole Minocycline-Induced DRESS Leading to Liver Transplantation and Type 1 Diabetes Increased Risk of Vertebral Fractures in Women Receiving Thiazide or Loop Diuretics Gambling Disorder and Impulse Control Disorder with Aripiprazole.
    Hosp Pharm 2017 Apr;52(4):253-257
    The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Read More

    Cardiopulmonary Resuscitation Training Disparities in the United States.
    J Am Heart Assoc 2017 May 17;6(5). Epub 2017 May 17.
    Department of Emergency Medicine and Center for Resuscitation Science, University of Pennsylvania, Philadelphia, PA
    Background: Bystander cardiopulmonary resuscitation (CPR) is associated with increased survival from cardiac arrest, yet bystander CPR rates are low in many communities. The overall prevalence of CPR training in the United States and associated individual-level disparities are unknown. We sought to measure the national prevalence of CPR training and hypothesized that older age and lower socioeconomic status would be independently associated with a lower likelihood of CPR training. Read More

    Relationship between CHOP/GADD153 and unstable human carotid atherosclerotic plaque.
    Br J Neurosurg 2017 May 17:1-5. Epub 2017 May 17.
    c Department of Neurosurgery , Dalian Municipal Central Hospital , Dalian , China.
    Background And Aims: The signaling protein C/EBP homologous protein (CHOP) and corresponding growth-arrest-and-DNA-damage-inducible gene 153 (GADD153) is associated with endoplasmic reticulum stress (ERS), which can lead to apoptosis. Our study aims to elucidate the role of CHOP/GADD153 in unstable atherosclerotic (AS) plaque formation isolated from confounding factors such as diabetes mellitus, primary hyperlipidemia, autoimmune deficiencies/abnormalities, essential hypertension, chronic heart failure, chronic kidney disease, and smoking.

    Material And Methods: We collected carotid artery tissue samples from patients aged 50-80 years-old who received carotid endarterectomies (CEA) at our institution. Read More

    Epileptiform discharge detection with the 4-channel frontal electroencephalography during post-resuscitation care.
    Resuscitation 2017 May 13. Epub 2017 May 13.
    Department of Emergency Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
    Introduction: We performed this study to investigate whether the SEDline system, a 4-channel-processed electroencephalography (EEG) monitoring device in the frontal area, can detect epileptiform discharges accurately during post-resuscitation care in comatose cardiac arrest survivors.

    Methods: Adult comatose cardiac arrest survivors, who were admitted to the intensive care unit (ICU) for post-resuscitation care including TTM, were enrolled. Within 72h post-return of spontaneous circulation (ROSC), conventional EEG was conducted for 30minutes. Read More

    A3 adenosine receptor agonist induce G1 cell cycle arrest via Cyclin D and cyclin-dependent kinase 4 pathways in OVCAR-3 and Caov-4 cell lines.
    J Cancer Res Ther 2017 Jan-Mar;13(1):107-112
    Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
    Aim Of The Study: The cell cycle, a vital process that involves in cells' growth and division, lies at the heart of cancer. It has been shown that IB-MECA, an A3 adenosine receptor agonist inhibits the proliferation of cancer cells by inducing cell cycle arrest in several tumors. In this study, we evaluated the role of IB-MECA inhibition in cell cycle progression in ovarian cancer cells. Read More

    Induction of hibernation-like hypothermia by central activation of the A1 adenosine receptor in a non-hibernator, the rat.
    J Physiol Sci 2017 May 15. Epub 2017 May 15.
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
    Central adenosine A1-receptor (A1AR)-mediated signals play a role in the induction of hibernation. We determined whether activation of the central A1AR enables rats to maintain normal sinus rhythm even after their body temperature has decreased to less than 20 °C. Intracerebroventricular injection of an adenosine A1 agonist, N6-cyclohexyladenosine (CHA), followed by cooling decreased the body temperature of rats to less than 20 °C. Read More

    Impact of chronic obstructive pulmonary disease on in-hospital morbidity and mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
    Int J Cardiol 2017 May 11. Epub 2017 May 11.
    University of Medicine and Pharmacy of Tîrgu Mureș, 540139 Tîrgu Mureș, Romania. Electronic address:
    Background: Patients with chronic obstructive pulmonary disease (COPD) presenting with ST-segment elevation myocardial infarction (STEMI) are less likely to beneficiate of primary percutaneous coronary intervention (pPCI), and have poorer prognosis. We aimed to evaluate the impact of COPD on the in-hospital outcomes of pPCI-treated STEMI patients.

    Methods: Data were collected from 418 STEMI patients treated by pPCI. Read More

    Comparison of Features of Fatal Versus Nonfatal Cardiac Arrest in Patients With Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy.
    Am J Cardiol 2017 Apr 13. Epub 2017 Apr 13.
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland. Electronic address:
    Once arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is diagnosed, the incidence of sudden cardiac death (SCD) is rare and prognosis is favorable, highlighting the value of early disease recognition. To inform strategies to diagnose ARVD/C before SCD, we sought to characterize clinical, genetic, and family history features of ARVD/C cases first recognized after SCD or resuscitated SCD (sudden cardiac arrest [SCA]). We identified 66 ARVD/C cases submitted to the Johns Hopkins ARVD/C Registry in whom disease was first recognized after SCD (n = 45) or SCA (n = 21) and compared their clinical, genetic, and demographic features with 352 patients (227 probands) diagnosed with ARVD/C by 2010 Task Force Criteria before any arrest. Read More

    Long-term Outcome After Survival of a Cardiac Arrest: A Prospective Longitudinal Cohort Study.
    Neurorehabil Neural Repair 2017 Jun 8;31(6):530-539. Epub 2017 Mar 8.
    1 Adelante, Centre of Expertise in Rehabilitation and Audiology, Hoensbroek, Netherlands.
    Background: A cardiac arrest can lead to hypoxic brain injury, which can affect all levels of functioning.

    Objective: To investigate 1-year outcome and the pattern of recovery after surviving a cardiac arrest.

    Methods: This was a multicenter, prospective longitudinal cohort study with 1 year of follow-up (measurements 2 weeks, 3 months, 1 year). Read More

    Transplantation 2017 May 13. Epub 2017 May 13.
    From the aUBC Centre for Heart Lung Innovation at St. Paul's Hospital, Vancouver, British Columbia, Canada; bDivision of Cardiovascular Surgery, St. Paul's Hospital, Vancouver, British Columbia, Canada; cDepartment of Pathology, University of British Columbia, Vancouver, British Columbia, Canada; and the dDepartment of Critical Care Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    Background: Organ donation after circulatory death (DCD) is increasingly being used as a means of addressing the organ supply/demand mismatch in solid organ transplantation. There is reluctance to use DCD hearts, due to an inability to precisely identify hearts that have suffered irreversible injury. We investigated novel biomarkers and clinically relevant endpoints across a spectrum of warm ischemic times (WITs), prior to and during ex vivo heart perfusion (EVHP), to identify features associated with a non-viable cardiac phenotype. Read More

    Early, intensive statin treatment reduces 'hard' cardiovascular outcomes after acute coronary syndrome.
    Eur J Prev Cardiol 2017 Jan 1:2047487317708677. Epub 2017 Jan 1.
    4 University of Linköping, Sweden.
    Background Early, intensive statin treatment is the standard of care after acute coronary syndrome (ACS). However, the benefit of this approach to prevent major adverse cardiovascular events has been demonstrated in only one randomised, placebo controlled trial. The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) trial demonstrated that atorvastatin 80 mg daily, compared with placebo, reduced time to first occurrence of death, non-fatal myocardial infarction, resuscitated cardiac arrest, or hospitalisation for unstable angina (stroke not included) during the 16 week period following ACS. Read More

    Successful use of lipid emulsion to resuscitate a foal after intravenous lidocaine induced cardiovascular collapse.
    Equine Vet J 2017 May 14. Epub 2017 May 14.
    Veterinary Teaching Hospital, University of Extremadura, Avda, Universidad s/n, Cáceres, 10003, Spain.
    Background: Lipid emulsion has been reported to be effective for the treatment of local anaesthetic overdoses in rats, dogs and humans.

    Objectives: To describe the successful treatment of cardiovascular lidocaine toxicity in a foal with intravenous lipid administration.

    Study Design: Observational study: case report. Read More

    Management of Patients With Cardiac Arrest Complicating Myocardial Infarction in New York Before and After Public Reporting Policy Changes.
    Circ Cardiovasc Interv 2017 May;10(5)
    From the Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.B.S., D.S.P., R.W.Y.); Division of Cardiology, University of Washington, Seattle (J.M.M.); Department of Medicine, Veterans Affairs Eastern Colorado Health Care System, Denver (S.W.W.); Division of Cardiology, St. Luke's/Mid America Heart Institute, Kansas City, MO (K.F.K.); and Greenberg Division of Cardiology, Weill Cornell Medical College, New York Presbyterian Hospital (D.N.F.).
    Background: In 2010, New York State began excluding selected patients with cardiac arrest and coma from publicly reported mortality statistics after percutaneous coronary intervention. We evaluated the effects of this exclusion on rates of coronary angiography, revascularization, and mortality among patients with acute myocardial infarction and cardiac arrest.

    Methods And Results: Using statewide hospitalization files, we identified discharges for acute myocardial infarction and cardiac arrest January 2003 to December 2013 in New York and several comparator states. Read More

    Fast therapeutic hypothermia prevents post-cardiac arrest syndrome through cyclophilin D-mediated mitochondrial permeability transition inhibition.
    Basic Res Cardiol 2017 Jul 10;112(4):35. Epub 2017 May 10.
    Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Réanimation Médicale, 5 Place d'Arsonval, 69437, Lyon Cedex 03, France.
    The opening of the mitochondrial permeability transition pore (PTP), which is regulated by the matrix protein cyclophilin D (CypD), plays a key role in the pathophysiology of post-cardiac arrest (CA) syndrome. We hypothesized that therapeutic hypothermia could prevent post-CA syndrome through a CypD-mediated PTP inhibition in both heart and brain. In addition, we investigated whether specific pharmacological PTP inhibition would confer additive protection to cooling. Read More

    Pediatric In-Hospital Acute Respiratory Compromise: A Report From the American Heart Association's Get With the Guidelines-Resuscitation Registry.
    Pediatr Crit Care Med 2017 May 10. Epub 2017 May 10.
    1Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA. 2Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark. 3Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark. 4Department of Anesthesiology, Critical Care and Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 5Department of Emergency Medicine, Hasbro Children's Hospital, Providence, RI. 6Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
    Objectives: The main objectives of this study were to describe in-hospital acute respiratory compromise among children (< 18 yr old), and its association with cardiac arrest and in-hospital mortality.

    Design: Observational study using prospectively collected data.

    Setting: U. Read More

    Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
    Neurology 2017 May 10. Epub 2017 May 10.
    From the Departments of Neurology, Anesthesiology-Critical Care Medicine, and Neurosurgery (R.G.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (E.W., A.R.), Mayo Clinic, Rochester, MN; Department of Neurology (M.J.A.), University of Florida-McKnight Brain Institute, Gainesville; Department of Neurology and Neurocritical Care Unit (M.D.), Cambridge University Hospitals; The Ipswich Hospital (M.D.), Cambridge, UK; Departments of Neurology and Neurosurgery (S.A.M.), Mount Sinai-Icahn School of Medicine, New York, NY; Departments of Emergency Medicine and Internal Medicine (Cardiology) (J.P.O.), Virginia Commonwealth University College of Medicine, Richmond; Department of Neurology (J.I.S.), Baylor College of Medicine, Houston, TX; Department of Neurology and Neurosurgery (M.T.T.), Ohio State University, Columbus; Department of Neurology (R.M.D.), Kansas University Medical Center, Kansas City; and Department of Neurology (J.L.), University of Toronto, Canada.
    Objective: To assess the evidence and make evidence-based recommendations for acute interventions to reduce brain injury in adult patients who are comatose after successful cardiopulmonary resuscitation.

    Methods: Published literature from 1966 to August 29, 2016, was reviewed with evidence-based classification of relevant articles.

    Results And Recommendations: For patients who are comatose in whom the initial cardiac rhythm is either pulseless ventricular tachycardia (VT) or ventricular fibrillation (VF) after out-of-hospital cardiac arrest (OHCA), therapeutic hypothermia (TH; 32-34°C for 24 hours) is highly likely to be effective in improving functional neurologic outcome and survival compared with non-TH and should be offered (Level A). Read More

    Trends in sex differences in clinical characteristics, treatment strategies, and mortality in patients with ST-elevation myocardial infarction in Poland from 2005 to 2011.
    Coron Artery Dis 2017 May 5. Epub 2017 May 5.
    a2nd Cardiology Clinic bDepartment of Interventional Cardiology, Swietokrzyskie Cardiology Center cInstitute of Medical Sciences dInstitute of Nursing and Obstetrics, The Faculty of Medicine and Health Sciences, The Jan Kochanowski University, Kielce e3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Silesian Centre for Heart Diseases, Medical University of Silesia in Katowice, Zabrze, Poland.
    Introduction: During the last decade, there has been an increased awareness of sex differences in the clinical characteristics, management, and mortality in myocardial infarction. Many previous studies have found that women with ST-elevation myocardial infarction (STEMI) have a poorer baseline risk profile, are less intensively treated, and have worse outcomes.

    Objective: To evaluate whether sex disparities in STEMI have changed in recent years. Read More

    Left ventricular noncompaction cardiomyopathy in a patient with trisomy 13: A report and review of the literature.
    Am J Med Genet A 2017 May 9. Epub 2017 May 9.
    Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Japan.
    Left ventricular noncompaction cardiomyopathy (LVNC) is characterized by prominent trabecular meshwork, and it is thought to result from arrest of the normal compaction process during embryogenesis. Patients with LVNC may be asymptomatic or have symptoms ranging from heart failure to stroke, life-threatening arrhythmias, or sudden death. The frequency of LVNC in children has increased with longer clinical courses. Read More

    Brugada syndrome and the story of Dave.
    Neuropsychol Rehabil 2017 May 10:1-9. Epub 2017 May 10.
    d The Raphael Medical Centre , Kent , UK.
    Brugada syndrome (BrS) is a little known genetic condition that causes severe disturbances in cardiac rhythm and may result in sudden unexpected cardiac death in an apparently healthy person. The heart structure is typically normal but there are problems with electrical activity. The syndrome is named after Spanish brothers who are cardiologists, Pedro and Josep Brugada. Read More

    Epidemiology of ventricular tachyarrhythmia : Any changes in the past decades?
    Herzschrittmacherther Elektrophysiol 2017 May 8. Epub 2017 May 8.
    H-1285, University of Ottawa Heart Institute, 40 Ruskin Street, K1Y 4W7, Ottawa, ON, Canada.
    Ventricular tachyarrhythmias include potentially lethal episodes of sustained ventricular tachycardia (VT) and ventricular fibrillation (VF) as well as hemodynamically tolerated ventricular ectopic activity. Sustained VT or VF may develop in the setting of acute myocardial infarction or as clinical sequelae of advanced cardiomyopathy. The incidence of these serious arrhythmias is estimated from retrospective and observational studies and registries of sudden cardiac arrest and sudden cardiac death. Read More

    Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model.
    Ann Transplant 2017 May 9;22:285-295. Epub 2017 May 9.
    Mixed Unit for Cardiovascular Repair, Institute of Sanitary Research La Fe-Príncipe Felipe Research Center, Valencia, Spain.
    BACKGROUND Cardioplegic arrest is a common procedure for many types of cardiac surgery, and different formulations have been proposed to enhance its cardio-protective effect. Hydrogen sulfide is an important signaling molecule that has cardio-protective properties. We therefore studied the cardio-protective effect of hydrogen sulfide in cardiac cell culture and its potential therapeutic use in combination with cardioplegia formulations. Read More

    Ambulatory Pulse Wave Velocity Is a Stronger Predictor of Cardiovascular Events and All-Cause Mortality Than Office and Ambulatory Blood Pressure in Hemodialysis Patients.
    Hypertension 2017 May 8. Epub 2017 May 8.
    From the Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Greece (P.A.S., C.L., G.T., A.P., G.E.); Therapeutiki Hemodialysis Unit, Thessaloniki, Greece (A.K.); Hemodialysis Unit, Achillopouleion General Hospital, Volos, Greece (G.K., C.S.); Pieria Hemodialysis Unit, Katerini, Greece (V.R.); Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Greece (V.L.); Manhès Hospital and FCRIN INI-CRCTC, Fleury Mérogis, France (G.L.); and CNR-IFC, Clinical Epidemiology and Pathophysiology of Hypertension and Renal Diseases Unit, Ospedali Riuniti, Reggio Calabria, Italy (C.Z.).
    Arterial stiffness and augmentation of aortic blood pressure (BP) measured in office are known cardiovascular risk factors in hemodialysis patients. This study examines the prognostic significance of ambulatory brachial BP, central BP, pulse wave velocity (PWV), and heart rate-adjusted augmentation index [AIx(75)] in this population. A total of 170 hemodialysis patients underwent 48-hour ambulatory monitoring with Mobil-O-Graph-NG during a standard interdialytic interval and followed-up for 28. Read More

    Effectiveness of finger-marker for maintaining the correct compression point during paediatric resuscitation: A simulation study.
    Am J Emerg Med 2017 Apr 11. Epub 2017 Apr 11.
    Interdisciplinary Program of Bioengineering, Seoul National University Graduate School, Seoul, Republic of Korea. Electronic address:
    Objective: High-quality cardiopulmonary resuscitation is a significant factor for increasing the survival rate of paediatric patients. This study is to investigate the effectiveness of finger-marker stickers for maintaining the correct compression point during simulated infant cardiopulmonary resuscitation (CPR).

    Methods: This crossover simulation study was conducted with 40 emergency physicians and paramedics at emergency departments of 2 tertiary hospitals. Read More

    Risk factors for sudden cardiac death in childhood hypertrophic cardiomyopathy: A systematic review and meta-analysis.
    Eur J Prev Cardiol 2017 Jan 1:2047487317702519. Epub 2017 Jan 1.
    1 Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, UK.
    Aims To perform a systematic literature review and meta-analysis of clinical risk factors for sudden cardiac death (SCD) in childhood hypertrophic cardiomyopathy. Methods Medline and PubMed databases were searched for original articles published in English from 1963 through to December 2015 that included patients under 18 years of age with a primary or secondary end-point of either SCD or SCD-equivalent events (aborted cardiac arrest or appropriate implantable cardioverter-defibrillator discharge) or cardiovascular death (CVD). Results Twenty-five studies (3394 patients) met the inclusion criteria. Read More

    Pharmacological Preconditioning with Diazoxide in the Experimental Hypothermic Circulatory Arrest Model.
    Heart Surg Forum 2017 Apr 30;20(2):E069-E076. Epub 2017 Apr 30.
    Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, London,.
    Background: Hypothermic circulatory arrest includes a remarkable risk for neurological injury. Diazoxide, a mitochondrial adenosine triphosphate-dependent potassium ion (K+ATP) channel opener, is known to have cardioprotective effects. We assessed its efficacy in preventing ischemic injury in a clinically relevant animal model. Read More

    Role of microRNA-124 in cardiomyocyte hypertrophy inducedby angiotensin II.
    Cell Mol Biol (Noisy-le-grand) 2017 Apr 29;63(4):23-27. Epub 2017 Apr 29.
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
    Cardiac hypertrophy is a crucial predictor of heart failure and is regulated by microRNAs. MicroRNA-124 (miR-124) is regarded as a prognostic indicator for outcomes after cardiac arrest. However, whether miR-124 participates in cardiac hypertrophy remains unclear. Read More

    Prognostic Factors After Index Hospitalization for Heart Failure With Preserved Ejection Fraction.
    Am J Cardiol 2017 Mar 30. Epub 2017 Mar 30.
    Department of Cardiology, Changi General Hospital, Singapore, Singapore.
    Heart failure with preserved ejection fraction (HFpEF) has a high clinical burden and constitutes approximately 20% to 30% of patients with heart failure in Asia. Impaired global longitudinal strain (GLS), defined as an absolute value of <15.8%, has been shown to be a predictor of heart failure hospitalization, cardiovascular death, and aborted cardiac arrest in HFpEF. Read More

    Disseminated intravascular coagulation is associated with the neurologic outcome of cardiac arrest survivors.
    Am J Emerg Med 2017 May 1. Epub 2017 May 1.
    Department of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
    Purpose: We aimed to examine the serial changes in coagulofibrinolytic markers that occurred after the restoration of spontaneous circulation (ROSC) in cardiac arrest patients, who were treated with targeted temperature management (TTM). We also evaluated the association between the disseminated intravascular coagulation (DIC) score and clinical outcomes.

    Methods: This was a single-centre, retrospective observational study that included cardiac arrest patients who were treated with TTM from May 2012 to December 2015. Read More

    The cost-effectiveness of a mechanical compression device in out of hospital cardiac arrest.
    Resuscitation 2017 May 2. Epub 2017 May 2.
    Warwick Clinical Trials Unit, University of Warwick, Coventry, CV4 7AL, UK; Heart of England NHS Foundation Trust, Bordesley Green, Birmingham, B9 5SS, UK.
    Aim: To assess the cost-effectiveness of LUCAS-2, a mechanical device for cardiopulmonary resuscitation (CPR) as compared to manual chest compressions in adults with non-traumatic, out-of-hospital cardiac arrest.

    Methods: We analysed patient-level data from a large, pragmatic, multi-centre trial linked to administrative secondary care data from the Hospital Episode Statistics (HES) to measure healthcare resource use, costs and outcomes in both arms. A within-trial analysis using quality adjusted life years derived from the EQ-5D-3L was conducted at 12-month follow-up and results were extrapolated to the lifetime horizon using a decision-analytic model. Read More

    Kids (learn how to) save lives in the school with the serious game Relive.
    Resuscitation 2017 May 2;116:27-32. Epub 2017 May 2.
    Italian Resuscitation Council (IRC), Scientific Committe, Bologna, Italy; Department of Anaesthesia and Intensive Care, Ospedale Maggiore, Bologna, Italy.
    Introduction: Relive is a serious game focusing on increasing kids and young adults' awareness on CPR. We evaluated the use of Relive on schoolchildren.

    Methods: A longitudinal, prospective study was carried out in two high schools in Italy over a 8-month period, divided in three phases: baseline, competition, and retention. Read More

    The association between AHA CPR quality guideline compliance and clinical outcomes from out-of-hospital cardiac arrest.
    Resuscitation 2017 May 2;116:39-45. Epub 2017 May 2.
    University of British Columbia, Vancouver, British, Colombia.
    Background: Measures of chest compression fraction (CCF), compression rate, compression depth and pre-shock pause have all been independently associated with improved outcomes from out-of-hospital (OHCA) cardiac arrest. However, it is unknown whether compliance with American Heart Association (AHA) guidelines incorporating all the aforementioned metrics, is associated with improved survival from OHCA.

    Methods: We performed a secondary analysis of prospectively collected data from the Resuscitation Outcomes Consortium Epistry-Cardiac Arrest database. Read More

    Topical Ice Slush Adversely Affects Sniff Nasal Inspiratory Force After Coronary Bypass Surgery.
    Heart Lung Circ 2017 Apr 6. Epub 2017 Apr 6.
    Department of Rehabilitation Science, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
    Background: Topical cooling with ice slush as an adjunct for myocardial protection during cardiac surgery has been shown to cause freezing injury of the phrenic nerves. This can cause diaphragmatic dysfunction and respiratory complications.

    Methods: Twenty (n=20) male patients between the ages of 40 and 60 years were equally randomised to undergo elective coronary artery bypass grafting (CABG) with either cold cardioplegic arrest with topical ice slush cooling or cold cardioplegic arrest without the use of ice slush. Read More

    Relevance of molecular testing in patients with a family history of sudden death.
    Forensic Sci Int 2017 Apr 13;276:18-23. Epub 2017 Apr 13.
    Kerckhoff Heart and Thorax Center, Benekestraße 2, 61231 Bad Nauheim, Germany.
    Sudden cardiac death (SCD) is a major cause of death in industrial countries. Although SCD occurs mainly in adults, it may also affect young persons, where genetic cardiac disorders comprise at least half of these cases. This includes primary arrhythmogenic disorders such as long QT syndrome and inherited cardiomyopathies. Read More

    Modalities and Effects of Left Ventricle Unloading on Extracorporeal Life support: a Review of the Current Literature.
    Eur J Heart Fail 2017 May;19 Suppl 2:84-91
    Department of Cardiothoracic Surgery, Maastricht University Medical Center +, Maastricht, The Netherlands.
    Introduction/aim: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support is increasingly used in refractory cardiogenic shock and cardiac arrest, but is characterized by a rise in afterload of the left ventricle (LV) which may ultimately either further impair or delay cardiac contractility improvement. The aim of this study was to provide a comprehensive overview regarding the different LV venting techniques and results currently available in the literature.

    Methods: A systematic literature search was performed in the PubMed database: 207 articles published between 1993 and 2016 were included. Read More

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