37,449 results match your criteria Astrocytoma


Tanycytic ependymoma of filum terminale: Clinical characteristics and surgical outcomes.

Oncol Lett 2018 Dec 1;16(6):6910-6917. Epub 2018 Oct 1.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China.

Tanycytic ependymoma (TE), a rare subtype of ependymoma, was classified as grade II ependymoma by the World Health Organization in 2000 and 2007. Preoperative diagnosis of TE is challenging due to its similarities to schwannoma and astrocytoma; therefore, differentiation is required. The present study investigated the clinical, imaging and pathological characteristics of TE in the filum terminale. Read More

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December 2018

Mathematical skills in children with pilocytic astrocytoma.

Acta Neurochir (Wien) 2018 Dec 6. Epub 2018 Dec 6.

IRCCS San Camillo Hospital Foundation, Neuropsychology Unit, Lido, Venice, Italy.

Background: Pediatric patients with circumscribed cerebellar pilocytic astrocytoma (PA) tumors generally perform within the normal range on neuropsychological tests after a complete tumor resection. The outcome in academically relevant abilities such as mathematics, which in adults involve some cerebellar functions, is however much less understood. The aim of this study is to retrospectively investigate the neuroplasticity of mathematical skills and associated cognitive functions following cerebellar resection of PA in pediatric patients. Read More

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December 2018

Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower grade gliomas: correlation with molecular groups.

J Neurooncol 2018 Dec 7. Epub 2018 Dec 7.

Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

Purpose: With the updated World Health Organization (WHO) 2016 neuropathological diagnostic criteria, radiographic prognostic associations in lower-grade gliomas (LGG, WHO grade II and III) are undergoing re-evaluation.

Methods: We identified 316 LGG patients (151 grade II and 165 grade III) for a combined cohort from three independent databases. We analyzed the preoperative axial FLAIR, axial T2-weighted and post-gadolinium volumetric T1-weighted MR images. Read More

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December 2018

OPTIC DISK ASTROCYTOMA UNASSOCIATED WITH TUBEROUS SCLEROSIS COMPLEX MANAGED WITH SURGICAL EXCISION AND A 7-YEAR FOLLOW-UP.

Authors:
Yao Lu Yimin Xu

Retin Cases Brief Rep 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Ministry of Education, Key Laboratory of Vision Loss and Restoration, Peking University Third Hospital, Beijing, China.

Purpose: Optic disk astrocytoma is a rare variant of congenital hamartoma, which is usually associated with tuberous sclerosis complex. Generally, it is stationary but in rare cases, it can show progressive growth and cause severe local complications.

Methods: Clinical-pathologic correlation. Read More

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November 2018

The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma.

Clin Cancer Res 2018 Dec 7. Epub 2018 Dec 7.

Clinical Cooperation Unit Pediatric Oncology (G340), Hopp Children's Cancer Center Heidelberg (KiTZ)

Purpose: Pilocytic astrocytoma (PA) is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced senescence (OIS), which may cause unpredictable growth behavior of PAs. The senescence-associated secretory phenotype (SASP) has been shown to regulate OIS, but its role in PA remains unknown. Read More

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December 2018
1 Read

Long-term health and social function in adult survivors of paediatric astrocytoma: A report from the Childhood Cancer Survivor Study.

Eur J Cancer 2018 Dec 4;106:171-180. Epub 2018 Dec 4.

Division of Haematology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Division of Oncology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Paediatrics, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Health Policy, Management, and Evaluation, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

Background: Although paediatric astrocytoma has an excellent 5-year survival rate, survivors remain at risk for morbidity and late mortality. This study aimed to estimate the risk of late mortality, chronic conditions, poor health status and social impairment in ageing paediatric astrocytoma survivors.

Methods: We longitudinally evaluated 1182 5-year astrocytoma survivors diagnosed between 1970 and 1986 and 4023 siblings enrolled in a retrospective cohort study. Read More

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December 2018

Prognostic factors and survival in low grade gliomas of the spinal cord: A population-based analysis from 2006 to 2012.

J Clin Neurosci 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Purpose: Primary spinal cord tumors are rare, and evidence-based management of these patients remains a source of controversy. This study used a large cohort of low-grade spinal cord astrocytomas to determine the effectiveness of prognostic factors and survival.

Methods: The Surveillance, Epidemiology, and End Results (SEER) cancer registry was used to identify patients with WHO grade I-II primary spinal cord astrocytomas from 1973 to 2012; however, patients before 2006 were excluded due to ambiguity diagnosis. Read More

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December 2018

Glioblastoma in a patient with tuberous sclerosis.

J Clin Neurosci 2018 Oct 24. Epub 2018 Oct 24.

Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia.

Tuberous sclerosis complex (TSC) is a multisystem, autosomal dominant disorder with a wide clinical spectrum. The most common brain tumor associated with TSC is the low grade subependymal giant cell astrocytoma. Reports of high grade primary brain tumors in patients with TSC are rare. Read More

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October 2018

expression is influenced by astrocytoma grade and polymorphism.

J Cancer 2018 31;9(23):4496-4502. Epub 2018 Oct 31.

Laboratory of Molecular Neurooncology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu str. 4, Kaunas, LT 50009, Lithuania.

Glial fibrillary acidic protein (GFAP) is an intermediate filament that provides mechanical support to astrocytes. is a single nucleotide polymorphism (SNP) located in the promoter region of the gene. The aim of this pilot study is to investigate expression at mRNA, protein levels and polymorphism in 50 different grade human astrocytoma samples. Read More

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October 2018
3 Reads

KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production.

Neoplasia 2018 Nov 29;21(1):52-60. Epub 2018 Nov 29.

Department of Neurology, Washington University, St. Louis, MO. Electronic address:

KIAA1549-BRAF is the most frequently identified genetic mutation in sporadic pilocytic astrocytoma (PA), creating a fusion BRAF (f-BRAF) protein with increased BRAF activity. Fusion-BRAF-expressing neural stem cells (NSCs) exhibit increased cell growth and can generate glioma-like lesions following injection into the cerebella of naïve mice. Increased Iba1 monocyte (microglia) infiltration is associated with murine f-BRAF-expressing NSC-induced glioma-like lesion formation, suggesting that f-BRAF-expressing NSCs attract microglia to establish a microenvironment supportive of tumorigenesis. Read More

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November 2018
1 Read

The Expressional Pattern of Invasion-Related Extracellular Matrix Molecules in CNS Tumors.

Cancer Invest 2018 Dec 3:1-12. Epub 2018 Dec 3.

a Department of Neurosurgery , University of Debrecen , Debrecen , Hungary.

Aim Of The Study: Astrocytomas are primary CNS malignancies which infiltrate the peritumoral tissue, even when they are low-grade. Schwannomas are also primary CNS tumors, however, they do not show peritumoral infiltration similarly to brain metastases which almost never invade the neighboring parts of brain. Extracellular matrix is altered in composition in various cancer types and is proposed to play an important role in the development of invasiveness of astrocytic tumors. Read More

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December 2018

Prenatal and postnatal presentation of PRMT7 related syndrome: Expanding the phenotypic manifestations.

Am J Med Genet A 2018 Dec 4. Epub 2018 Dec 4.

Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.

Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyze the transfer of methyl groups from S-adenosyl-l-methionine to nitrogen atoms on arginine residues. Arginine methylation is involved in multiple biological processes, such as signal transduction, mRNA splicing, transcriptional control, DNA repair, and protein translocation. Currently, 10 patients have been described with mutations in PRMT7. Read More

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December 2018
2 Reads

The level of microRNA 21 is upregulated by rapamycin in serum of tuberous sclerosis complex patients and subependymal giant cell astrocytoma (SEGA)-derived cell cultures.

Folia Neuropathol 2018 ;56(3):167-174

Tuberous sclerosis complex (TSC) represents a genetic condition, in which the clinical manifestations are caused by the disinhibition of the mammalian target of rapamycin (mTOR) pathway due to mutations in the TSC1 (hamartin) or TSC2 (tuberin) genes. The deregulated mTOR activity leads to multi-site tumors, including subependymal giant cell astrocytoma (SEGA). SEGA is a brain tumor that affects around 15% of TSC patients. Read More

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January 2018
1 Read

Anaplastic Astrocytoma in a Child With Coffin-Siris Syndrome and a Germline SMARCE1 Mutation: A Case Report.

J Pediatr Hematol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Oncology, Division of Neuro-Oncology, St. Jude Children's Research Hospital.

Coffin-Siris syndrome (CSS) is a rare congenital disorder with variable clinical phenotype consisting of developmental delay and characteristic facial features. It is caused by mutations in the chromatin remodeling switch/sucrose nonfermenting complex. Although SWI/SNF genes are widely implicated in tumorigenesis, only 8 cases of neoplasm have been reported in patients with CSS. Read More

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November 2018
1 Read

ATRX protein loss and deregulation of PI3K/AKT pathway is frequent in pilocytic astrocytoma with anaplastic features.

Clin Neuropathol 2018 Nov 30. Epub 2018 Nov 30.

Introduction: Pilocytic astrocytoma (PA) with anaplastic features (PAAF) is a rare entity associated with decreased survival. It is characterized by hypercellularity, atypia, brisk mitotic activity, variable necrosis, and association with a classic PA component or anaplastic transformation in a recurrent tumor with a previously-documented classic PA.

Materials And Methods: We present 5 PAAF cases with clinical, radiological, pathological, and molecular correlation. Read More

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November 2018

Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60.

J Neurooncol 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurological Surgery, University of California, San Francisco, CA, USA.

Purpose: WHO grade II gliomas are uncommon in patients over the age of 60, and there is a lack in consensus regarding their management. We present molecular tumor characteristics as well as clinical outcomes in patients over the age of 60 undergoing surgical resection of a WHO grade II glioma.

Methods: After receiving IRB approval, patients were identified through the UCSF Brain Tumor Center. Read More

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November 2018
1 Read

Ictal piloerection is associated with high-grade glioma and autoimmune encephalitis-Results from a systematic review.

Seizure 2018 Nov 22;64:1-5. Epub 2018 Nov 22.

Department of Neurology, University of Pécs, H-7623, Rét u. 2., Pécs, Hungary; PTE-MTA Clinical Neuroscience MR Research Group, H-7623, Rét u. 2, Hungary. Electronic address:

Purpose: To comprehensively analyze ictal piloerection (IP) in a large number of subjects.

Methods: We performed a systematic review on case report studies of patients diagnosed with IP (1929-2017) with additional cases included from the Department of Neurology of University of Pécs, the National Institute of Clinical Neurosciences, and Odense University Hospital. Each included case was characterized regarding patient history, IP seizure characteristics, diagnostic work-up, and therapy. Read More

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November 2018
1 Read

Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Two techniques, the translongitudinal cerebral fissure and transfrontal cortical approach, can be employed to resect posterior cingulate gyrus tumors. We demonstrate the transcortical technique comprising of multimodal imaging guidance and awake brain mapping which enabled maximum safe resection of dominant cingulate gyrus glioma. The patient, a 49-yr-old female, came to clinic after experiencing headache for a month. Read More

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November 2018
3 Reads

Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes.

Authors:

J Neurosurg Spine 2018 Oct 1:1-7. Epub 2018 Oct 1.

OBJECTIVEThe intraoperative differentiation of ependymomas from astrocytomas is important because neurosurgical strategies differ between these two tumor groups. Previous studies have reported that the diagnostic accuracy of intraoperative frozen sections of intracranial central nervous system (CNS) tumors is higher than 83%-97%, whereas that for spinal intramedullary tumors remains unknown. Herein, authors tested the hypothesis that intraoperative frozen-section diagnosis is the gold standard for a differential diagnosis of intramedullary spinal cord tumors. Read More

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October 2018

Outcomes and prognostic stratification of patients with recurrent glioblastoma treated with salvage stereotactic radiosurgery.

Authors:

J Neurosurg 2018 Oct 1:1-11. Epub 2018 Oct 1.

OBJECTIVEGlioblastoma (GBM) is the most malignant form of astrocytoma. The average survival is 6-10 months in patients with recurrent GBM (rGBM). In this study, the authors evaluated the role of stereotactic radiosurgery (SRS) in patients with rGBMs. Read More

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October 2018
3 Reads

Kainate Receptor Activation Enhances Amyloidogenic Processing of APP in Astrocytes.

Mol Neurobiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.

Kainic acid (KA) is an analogue of the excitatory neurotransmitter glutamate that, when injected systemically into adult rats, can trigger seizures and progressive neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy. However, biomolecular mechanisms responsible for the neuronal loss that occurs as a consequence of this treatment remains elusive. We have recently reported that toxicity induced by KA can partly be mediated by astrocyte-derived amyloid β (Aβ) peptides, which are critical in the development of Alzheimer's disease (AD). Read More

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November 2018

Integrative cross-platform analyses identify enhanced heterotrophy as a metabolic hallmark in glioblastoma.

Neuro Oncol 2018 Nov 10. Epub 2018 Nov 10.

Radiation Oncology, Beaumont Health, Royal Oak, MI, USA.

Background: Although considerable progress has been made in understanding molecular alterations driving gliomagenesis, the diverse metabolic programs contributing towards the aggressive phenotype of glioblastoma remain unclear. The aim of this study was to define and provide molecular context to metabolic reprogramming driving gliomagenesis.

Methods: Integrative cross-platform analyses coupling global metabolomic profiling with genomics in patient-derived glioma (low-grade astrocytoma [LGA; n=28] and glioblastoma [n=80]) was performed. Read More

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November 2018
1 Read

Periostin concentrations in childhood-onset craniopharyngioma patients.

J Endocrinol Invest 2018 Nov 24. Epub 2018 Nov 24.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, 26133, Oldenburg, Germany.

Purpose: Periostin is highly expressed in craniopharyngioma (CP)-associated fibroblasts and has been identified as a marker for non-alcoholic fatty liver disease (NAFLD). Half of CP patients with hypothalamic syndrome develop NAFLD. We hypothesized that periostin concentration is elevated in biological fluids of CP and associated with pathological hepatic parameters, indicating increased risk for NAFLD. Read More

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November 2018
2 Reads

Secondary sacral tethered cord syndrome after treatment of secondary cervical syringomyelia.

J Clin Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurosurgery, HELIOS Klinikum, Erfurt, Germany.

A female patient operated at the age of 11 on a pilocytic astrocytoma in the posterior fossa, was re-operated for a recurrence 9 years later. A Torkildsen drain was placed in the 4th ventricle and she remained asymptomatic for 15 years before presenting again with acute hydrocephalus, tonsillar herniation, and a massive cervicothoracic syrinx. The symptoms retreated following craniocervical untethering and decompression. Read More

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November 2018
1 Read

Evidence for Improving Outcome Through Extent of Resection.

Neurosurg Clin N Am 2019 Jan 1;30(1):85-93. Epub 2018 Nov 1.

Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, M779, San Francisco, CA 94143-0112, USA.

Surgical resection plays a central role in the management of gliomas however many tumors are within areas resulting in sensorimotor and cognitive consequences. This article reviews the evidence in support of extent of resection to improve survival, symptom management, and time to malignant transformation in low-grade gliomas. The authors summarize the evolving literature regarding the role of maximal safe resection in light of WHO subclassification of low-grade gliomas. Read More

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January 2019
15 Reads

Molecular Pathogenesis of Low-Grade Glioma.

Neurosurg Clin N Am 2019 Jan;30(1):17-25

Department of Neurosurgery, Kimmel Center for Stem Cell Biology, Laura and Isaac Perlmutter Cancer Center, Neuroscience Institute, Brain Tumor Center, NYU School of Medicine, 530 First Avenue, Skirball 8R, New York, NY 10016, USA. Electronic address:

Advances in genome sequencing have elucidated the genetics of low-grade glioma. Available evidence indicates a neomorphic mutation in isocitrate dehydrogenase (IDH) initiates gliomagenesis. Mutant IDH produces the oncometabolite 2-hydroxyglutarate, which inhibits enzymes that demethylate genomic DNA and histones. Read More

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January 2019
7 Reads

Different behaviour of DVL1, DVL2, DVL3 in astrocytoma malignancy grades and their association to TCF1 and LEF1 upregulation.

J Cell Mol Med 2018 Nov 23. Epub 2018 Nov 23.

Laboratory of Neuro-oncology, Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.

Key regulators of the Wnt signalling, DVL1, DVL2 and DVL3, in astrocytomas of different malignancy grades were investigated. Markers for DVL1, DVL2 and DVL3 were used to detect microsatellite instability (MSI) and gross deletions (LOH), while immunohistochemistry and immunoreactivity score were used to determine the signal strengths of the three DVL proteins and transcription factors of the pathway, TCF1 and LEF1. Our findings demonstrated that MSI at all three DVL loci was constantly found across tumour grades with the highest number in grade II (P = 0. Read More

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November 2018
5 Reads

Surgical management of lower-grade glioma in the spotlight of the 2016 WHO classification system.

J Neurooncol 2018 Nov 22. Epub 2018 Nov 22.

Department of Neurosurgery, Medical Center, Freiburg, Germany.

Purpose: According to the 2016 WHO classification lower-grade gliomas consist of three groups: IDH-mutated and 1p/19q co-deleted, IDH-mutated and IDH-wildtype tumors. The aim of this study was to evaluate the impact of surgical therapy for lower-grade gliomas with a particular focus on the molecular subgroups.

Methods: This is a bi-centric retrospective analysis including 299 patients, who underwent treatment for lower-grade glioma between 1990 and 2016. Read More

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November 2018
2 Reads

MRI based texture analysis to classify low grade gliomas into astrocytoma and 1p/19q codeleted oligodendroglioma.

Magn Reson Imaging 2018 Nov 19. Epub 2018 Nov 19.

Department of Radiology, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Purpose: Texture analysis performed on MR images can detect quantitative features that are imperceptible to human visual assessment. The purpose of this study was to evaluate the feasibility of texture analysis on preoperative conventional MRI to discriminate between histological subtypes in low-grade gliomas (LGGs), and to determine the utility of texture analysis compared to histogram analysis alone.

Methods: A total of 41 patients with LGG, 21 astrocytoma and 20 1p/19q codeleted oligodendroglioma were included in this study. Read More

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November 2018
2 Reads

Trends in pediatric central nervous system tumor incidence in the United States, 1998-2013.

Cancer Epidemiol Biomarkers Prev 2018 Nov 21. Epub 2018 Nov 21.

Division of Cancer Epidemiology and Genetics, National Cancer Institute.

Background: Brain and other central nervous system (CNS) cancers are the leading cause of US pediatric cancer mortality. Incidence trends can provide etiological insight. We report trends in incidence rates of pediatric malignant CNS cancers and pilocytic astrocytoma (non-malignant but historically registered) in the US. Read More

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November 2018
4 Reads

Pilocytic Astrocytoma with Gangliocytic Differentiation to Pilomyxoid Astrocytoma-expanding the Morphological Spectrum: Case Report and Literature Review.

Asian J Neurosurg 2018 Oct-Dec;13(4):1193-1196

Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

We present a rare case of pilocytic astrocytoma (PA) with gangliocytic differentiation arising in the suprasellar/chiasmatic region in a young boy that showed a rapid regrowth after the 1 subtotal resection and "differentiated" into pilomyxoid astrocytoma (PMA) in subsequent recurrences. The clinical course, imaging, and histological features have been described with a review of the literature. While PA is well-circumscribed, biphasic tumors with bipolar piloid cells, those arising in the diencephalic region often contain myxoid stroma, angiocentric pattern, and "intermediate" features between PA and PMA. Read More

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November 2018
5 Reads

Clinical relevance of screening checklists for detecting cancer predisposition syndromes in Asian childhood tumours.

NPJ Genom Med 2018 15;3:30. Epub 2018 Nov 15.

1Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, 169610 Singapore.

Assessment of cancer predisposition syndromes (CPS) in childhood tumours is challenging to paediatric oncologists due to inconsistent recognizable clinical phenotypes and family histories, especially in cohorts with unknown prevalence of germline mutations. Screening checklists were developed to facilitate CPS detection in paediatric patients; however, their clinical value have yet been validated. Our study aims to assess the utility of clinical screening checklists validated by genetic sequencing in an Asian cohort of childhood tumours. Read More

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November 2018
3 Reads

A malignant astrocytoma with uncommon angiocentric features and dot-like EMA expression.

Contemp Oncol (Pozn) 2018 30;22(3):205-208. Epub 2018 Sep 30.

Department of Pathology, Chair of Oncology, Medical University of Lodz, Poland.

Angiocentric features are uncommon in high-grade World Health Organisation (WHO) brain tumours, whilst they are typical for WHO grade I tumours, e.g. angiocentric gliomas. Read More

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September 2018
4 Reads

Potential bioisosteres of β-uracilalanines derived from 1H-1,2,3-triazole-C-carboxylic acids.

Bioorg Chem 2018 Nov 7;83:500-510. Epub 2018 Nov 7.

Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland. Electronic address:

The 1H-1,2,3-triazole-originated derivatives of willardiine were obtained by: (i) construction of the 1H-1,2,3-triazole ring in 1,3-dipolar cycloaddition of the uracil-derived azides and the carboxylate-bearing alkynes or α-acylphosphorus ylide, or (ii) N-alkylation of the uracil derivative with the 1H-1,2,3-triazole-4-carboxylate-derived mesylate. The latter method offered: (i) reproducible results, (ii) a significant reduction of amounts of auxiliary materials, (iii) reduction in wastes and (iv) reduction in a number of manual operations required for obtaining the reaction product. Compound 6a exhibited significant binding affinity to hHS1S2I ligand-binding domain of GluR2 receptor (EC = 2. Read More

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November 2018
3 Reads

Retinal astrocytoma in a young male with PTEN hamartoma tumor syndrome.

J AAPOS 2018 Nov 14. Epub 2018 Nov 14.

Division of Ophthalmology, Warren Alpert Medical School, Brown University, Providence, Rhode Island.

We present the novel finding of retinal astrocytoma in a 15-year-old boy with phosphatase and tensin homologue hamartoma tumor syndrome, confirmed by genetic testing. Read More

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November 2018
2 Reads

Tumour volume reduction following PET guided intensity modulated radiation therapy and temozolomide in IDH mutated anaplastic glioma.

J Clin Neurosci 2018 Nov 14. Epub 2018 Nov 14.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Sydney NeuroOncology Group, Sydney, Australia.

The role of maximal surgical debulking in isocitrate dehydrogenase (IDH) mutated anaplastic glioma prior to adjuvant radiation therapy remains uncertain. This study assessed the reduction in tumour volume following intensity modulated radiation therapy (IMRT) and temozolomide in this favourable and more responsive tumour pathology. 56 patients were managed from 2011 to 2014 and 53 had residual disease. Read More

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November 2018
1 Read

Long-term Seizure Disorder Caused by a Dermoid Cyst with Catastrophic Developments.

Cureus 2018 Sep 10;10(9):e3272. Epub 2018 Sep 10.

Surgery/Neurosurgery, University of Toledo Medical Center, Toledo, USA.

Glioblastoma multiforme (GBM) is a World Health Organization (WHO) grade IV primary malignant astrocytoma. Aneurysms are devastating intracranial neurovascular pathologies. Intracranial dermoid cysts are common, benign lesions which can be clinically silent or associated with seizure disorder. Read More

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September 2018
4 Reads

Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior.

Pediatr Neurosurg 2018 14;53(6):395-400. Epub 2018 Nov 14.

Children's Hospital LA, Los Angeles, California, USA.

Background/aims: Pilocytic astrocytomas are common pediatric tumors. Molecular profiles vary with location of origin. Comparisons of proliferation have not been reported. Read More

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November 2018
5 Reads

Nanotechnology for Treatment of Glioblastoma Multiforme.

J Transl Int Med 2018 Sep 9;6(3):128-133. Epub 2018 Oct 9.

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Glioblastoma multiforme (GBM), a grade IV astrocytoma as defined by the World Health Organization (WHO) criteria, is the most common primary central nervous system tumor in adults. After treatment with the current standard of care consisting of surgical resection, concurrent temozolomide (TMZ), and radiation, the median survival is only 15 months. The limited and less-effective treatment options for these highly aggressive GBMs call for the development of new techniques and the improvement of existing technologies. Read More

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September 2018
5 Reads

Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex.

Pediatr Neurol 2018 Oct 18. Epub 2018 Oct 18.

Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objective: We studied the longitudinal effects of everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), on callosal white matter diffusion tensor imaging (DTI) in patients with tuberous sclerosis complex (TSC).

Methods: Serial imaging data spanning nine years were used from the open label, Phase I/II trial (NCT00411619) and open-ended extension phase of everolimus for the treatment of subependymal giant cell astrocytoma associated with TSC. From 28 patients treated with everolimus and 25 untreated control patients, 481 MRI scans were available. Read More

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October 2018
3 Reads

Differentiation between pilocytic astrocytoma and glioblastoma: a decision tree model using contrast-enhanced magnetic resonance imaging-derived quantitative radiomic features.

Eur Radiol 2018 Nov 12. Epub 2018 Nov 12.

Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Objective: To differentiate brain pilocytic astrocytoma (PA) from glioblastoma (GBM) using contrast-enhanced magnetic resonance imaging (MRI) quantitative radiomic features by a decision tree model.

Methods: Sixty-six patients from two centres (PA, n = 31; GBM, n = 35) were randomly divided into training and validation data sets (about 2:1). Quantitative radiomic features of the tumours were extracted from contrast-enhanced MR images. Read More

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November 2018
5 Reads
4.014 Impact Factor

Conformal Radiation Therapy for Pediatric Patients with Low-Grade Glioma: Results from the Children's Oncology Group Phase II Study XXXX.

Int J Radiat Oncol Biol Phys 2018 Nov 9. Epub 2018 Nov 9.

Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN. Electronic address:

Purpose: To determine the rate of marginal relapse, progression-free survival (PFS), and overall survival (OS) in patients with pediatric low-grade glioma (PLGG) treated with conformal radiation therapy (CRT) with a clinical target volume (CTV) margin of 5 mm in the Children's Oncology Group trial XXXX.

Methods And Materials: Children (age 3-21 years) with unresectable progressive, recurrent, or residual PLGG were eligible for this study. Patients younger than 10 years were required to have received at least 1 chemotherapy course. Read More

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November 2018
5 Reads

"Integrated diagnosis" of pilocytic astrocytoma: Molecular diagnostic procedure for an unusual case.

Pathol Int 2018 Nov 12. Epub 2018 Nov 12.

Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

A 24 year-old female presented with a mass lesion in the right temporal lobe. This case was difficult to diagnose using histological and immunological methods and therefore molecular analyses were applied to provide a definitive diagnosis. The tumor was well-demarcated, partially cystic, and irregularly-enhanced on gadolinium-enhanced T1-weighted magnetic resonance images. Read More

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November 2018
6 Reads

Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970-99: a report from the Childhood Cancer Survivor Study cohort.

Lancet Oncol 2018 Dec 8;19(12):1590-1601. Epub 2018 Nov 8.

Duke University School of Medicine, Durham, NC, USA.

Background: Treatments for childhood cancer have evolved over the past 50 years, with the goal of maximising the proportion of patients who achieve long-term survival, while minimising the adverse effects of therapy. We aimed to assess incidence patterns of serious chronic health conditions in long-term survivors of childhood cancer across three decades of diagnosis and treatment.

Methods: We used data from the Childhood Cancer Survivor Study, a retrospective cohort with longitudinal follow-up of 5-year survivors of common childhood cancers (leukaemia, tumours of the CNS, Hodgkin lymphoma, non-Hodgkin lymphoma, Wilms tumour, neuroblastoma, soft tissue sarcoma, or bone tumours) who were diagnosed before the age of 21 years and from 1970 to 1999 in North America. Read More

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December 2018
4 Reads

A Rare Case of Metastases from a High-grade Astrocytoma to the Pleura, Bones, and Liver within Six Months of Diagnosis.

Cureus 2018 Aug 30;10(8):e3234. Epub 2018 Aug 30.

Hematology and Oncology, Marshall University, Joan C. Edwards School of Medicine, Huntington, USA.

High grade astrocytomas such as anaplastic astrocytoma and glioblastoma multiforme are aggressive central nervous system malignancies with a poor prognosis. Due to shortened survival times, their devastating effects are usually localized intracranially and rarely metastasize outside of the central nervous system. When metastases occur, they usually present in patients with longer survival times and they typically coincide with a primary site recurrence. Read More

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August 2018
2 Reads

Neuroendoscopic biopsy: analysis of a series of 80 patients.

Neurosurg Rev 2018 Nov 7. Epub 2018 Nov 7.

Neurosurgery Department, Hospital Regional Universitario, University of Malaga, Av. Carlos Haya, s/n 29010, Málaga, Spain.

Neuroendoscopy enables diagnostic biopsy of intraventricular and/or paraventricular tumors and the simultaneous treatment of associated hydrocephalus in selected cases. The objective of this paper was to analyze the effectiveness and safety of this procedure. This retrospective study included 80 patients between 2 months and 78 years old diagnosed with intraventricular and/or paraventricular expansive lesion who underwent neuroendoscopic biopsy from 2004 to 2016. Read More

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November 2018
5 Reads

Migraine-like visual aura: Can it be an early-onset symptom of astrocytoma?

Agri 2018 Oct;30(4):202-205

Department of Neurology, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.

Photopsia, fortification spectra, and the slow propagation of a scintillating scotoma across the visual field are typical diagnostic features of the visual aura of migraine. In the vast majority of cases, the diagnosis can be made without the need for further investigations. Herein, we report three consecutive cases with an astrocytoma and discuss clinical features of migraine-like visual aura. Read More

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October 2018
2 Reads

Comprehensive analysis of Reverse Phase Protein Array data reveals characteristic unique proteomic signatures for glioblastoma subtypes.

Gene 2018 Oct 25;685:85-95. Epub 2018 Oct 25.

Department of Bio-Medical Sciences, School of Biosciences and Technology, VIT University, Vellore 632014, India. Electronic address:

The most common and lethal type of intracranial tumors include the astrocytomas. Grade IV astrocytoma or Glioblastoma (GBM) is highly aggressive and treatment-refractory with a median survival of only 14 to 16 months. Molecular profiling of GBMs reveals a high degree of intra- and inter-tumoral heterogeneity, and hence it is important to understand the important signalling axes that get deregulated in different GBM subtypes to provide effective tailor-made therapies. Read More

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October 2018
1 Read

Mathematically universal and biologically consistent astrocytoma genotype encodes for transformation and predicts survival phenotype.

APL Bioeng 2018 Sep 19;2(3). Epub 2018 Sep 19.

Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah 84112, USA.

DNA alterations have been observed in astrocytoma for decades. A copy-number genotype predictive of a survival phenotype was only discovered by using the generalized singular value decomposition (GSVD) formulated as a comparative spectral decomposition. Here, we use the GSVD to compare whole-genome sequencing (WGS) profiles of patient-matched astrocytoma and normal DNA. Read More

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September 2018
3 Reads

The role of ABO blood groups in glial neoplasms.

Br J Neurosurg 2018 Nov 4:1-4. Epub 2018 Nov 4.

b Radiation Oncology , Hacettepe University School of Medicine , Ankara , Turkey.

Introduction: There are numerous diseases that are claimed to have a correlation with AB0 blood groups. Analysis on distribution of blood groups in primary brain tumors and clinical value has revealed conflicting results. The purpose of this study is to evaluate the association between AB0 blood groups and glial neoplasms (GN) and their effects on prognosis. Read More

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November 2018
1 Read