38,314 results match your criteria Astrocytoma


Modelling MR and clinical features in grade II/III astrocytomas to predict IDH mutation status.

Eur J Radiol 2019 May 14;114:120-127. Epub 2019 Mar 14.

Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK; National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Background And Purpose: There is increasing evidence that many IDH wildtype (IDHwt) astrocytomas have a poor prognosis and although MR features have been identified, there remains diagnostic uncertainty in the clinic. We have therefore conducted a comprehensive analysis of conventional MR features of IDHwt astrocytomas and performed a Bayesian logistic regression model to identify critical radiological and basic clinical features that can predict IDH mutation status.

Materials And Methods: 146 patients comprising 52 IDHwt astrocytomas (19 WHO Grade II diffuse astrocytomas (A II) and 33 WHO Grade III anaplastic astrocytomas (A III)), 68 IDHmut astrocytomas (53 A II and 15 A III) and 26 GBM were studied. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.03.003DOI Listing

Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours.

J Neurooncol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Introduction: Tumour-associated angiogenesis is associated with the malignancy and poor prognosis of glioma. Isocitrate dehydrogenase (IDH) mutations are present in the majority of lower-grade (WHO grade II and III) and secondary glioblastomas, but their roles in tumour angiogenesis remain unclear.

Methods: Using magnetic resonance imaging (MRI), the cerebral blood flow (CBF) of IDH-mutated glioma was measured and compared with the IDH-wildtype glioma. Read More

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http://link.springer.com/10.1007/s11060-019-03156-5
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http://dx.doi.org/10.1007/s11060-019-03156-5DOI Listing
April 2019
1 Read

A novel mutation in the gene expands the phenotype of Alexander disease.

J Med Genet 2019 Apr 19. Epub 2019 Apr 19.

Neurometabolic Diseases Laboratory, Institut d'Investigacio Biomedica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat (Barcelona), Catalonia, Spain

Background: Alexander disease, an autosomal dominant leukodystrophy, is caused by missense mutations in . Although mostly diagnosed in children, associated with severe leukoencephalopathy, milder adult forms also exist.

Methods: A family affected by adult-onset spastic paraplegia underwent neurological examination and cerebral MRI. Read More

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2018-105959
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http://dx.doi.org/10.1136/jmedgenet-2018-105959DOI Listing
April 2019
1 Read
6.335 Impact Factor

Twenty-three years follow-up after low-dose Gamma Knife surgery of a brainstem juvenile pilocytic astrocytoma: a case report and review of the literature.

Childs Nerv Syst 2019 Apr 17. Epub 2019 Apr 17.

Division of Neurosurgery, National University Hospital, Singapore, Singapore.

Juvenile pilocytic astrocytoma (JPA) is a World Health Organization (WHO) grade I tumor that is the commonest to occur in the 0-19 age group, with an excellent prognosis of 96% 10-year survival in pediatric patients. Complete resection is the treatment of choice for JPAs. However, this is not always feasible due to the location of certain tumors, and the management following subtotal resection is controversial. Read More

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http://link.springer.com/10.1007/s00381-019-04147-7
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http://dx.doi.org/10.1007/s00381-019-04147-7DOI Listing
April 2019
2 Reads

Investigation on 2',3'--Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists.

ACS Med Chem Lett 2019 Apr 26;10(4):493-498. Epub 2018 Dec 26.

School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, via S. Agostino 1, 62032 Camerino, MC, Italy.

Antagonists of the purinergic P2X3 receptors represent promising drugs for the treatment of inflammation and pain. The ATP derivative 2',3'--(2,4,6-trinitrophenyl)-ATP (TNP-ATP) has been described as a potent competitive inhibitor of this receptor. In this work, the design and synthesis of novel TNP-ATP analogues bearing alkyl groups in the 2',3'-position are reported. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466514PMC

Usefulness of [C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma.

Neurol Med Chir (Tokyo) 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Tokyo Medical and Dental University.

Tumefactive multiple sclerosis (tumefactive MS) is an atypical variant of MS characterized by a large isolated demyelinating lesion. Because tumefactive MS mimics high grade astrocytoma clinically and radiologically, it is difficult to distinguish between the two using only traditional diagnostic modalities, such as routine magnetic resonance imaging. [C] methionine positron emission tomography (MET PET) has been known as a useful diagnostic tool for glioma. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0287DOI Listing

A vascular-task response dependency and its application in functional imaging of brain tumors.

J Neurosci Methods 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiology, Weill Cornell Medicine, New York, NY, USA; Functional MRI Laboratory, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Neuroscience, Weill-Cornell Graduate School of the Medical Sciences, New York, NY, USA.

Purpose: Preoperative functional MRI (fMRI) is limited by a muted BOLD response caused by abnormal vasoreactivity and resultant neurovascular uncoupling adjacent to malignant brain tumors. We propose to overcome this limitation and more accurately identify eloquent areas adjacent to brain tumors by independently assessing vasoreactivity using breath-holding and incorporating these data into the fMRI analysis.

Methods: Local vasoreactivity using a breath-holding paradigm with the same timing as the functional motor and language tasks was determined in 16 patients (9 glioblastomas, 1 anaplastic astrocytoma, 5 low grade astrocytomas, and 1 metastasis) and 6 healthy control subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650270193011
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http://dx.doi.org/10.1016/j.jneumeth.2019.04.004DOI Listing
April 2019
3 Reads

5-ALA fluorescence-guided surgery in pediatric brain tumors-a systematic review.

Acta Neurochir (Wien) 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurosurgery, University Hospital Münster, Germany Albert-Schweitzer-Campus 1, Building A1, 48149, Munster, Germany.

Background: 5-Aminolevulinic acid (5-ALA)-guided resection of gliomas in adults enables better differentiation between tumor and normal brain tissue, allowing a higher degree of resection, and improves patient outcomes. In recent years, several reports have emerged regarding the use of 5-ALA in other brain tumor entities, including pediatric brains tumors. Since gross total resection (GTR) of many brain tumors in children is crucial and the role of 5-ALA-guided resection of these tumors is not clear, we sought to perform a comprehensive literature review on this topic. Read More

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http://link.springer.com/10.1007/s00701-019-03898-1
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http://dx.doi.org/10.1007/s00701-019-03898-1DOI Listing
April 2019
2 Reads

The impact of adjuvant radiotherapy on molecular prognostic markers in gliomas.

Onco Targets Ther 2019 26;12:2215-2224. Epub 2019 Mar 26.

Department of Pathology, Laboratory of Clinical Genetics and Molecular Pathology, 10th Military Hospital, Bydgoszcz, Poland.

Purpose: Changes in promoter methylation, and mutation, and 1p/19q co-deletion status in gliomas between first and subsequent resections and their associated clinical factors are poorly described. In this study, we assayed these biomarkers in the clinical setting.

Patients And Methods: We used multiplex ligation-dependent probe amplification to measure promoter methylation, mutation status, and 1p/19q co-deletion in 45 paired tumor samples from patients undergoing resection and subsequent re-resections for gliomas. Read More

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http://dx.doi.org/10.2147/OTT.S200818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441459PMC
March 2019
1 Read

Incidence trends of adult malignant brain tumors in Finland, 1990-2016.

Acta Oncol 2019 Apr 15:1-7. Epub 2019 Apr 15.

b Faculty of Social Sciences , University of Tampere , Tampere , Finland.

Background: Several studies have reported increased incidence trends of malignant gliomas in the late 1900s with a plateau in the 2000s, but also some recent increases have been reported. The purpose of our study was to analyze incidence trends of malignant gliomas in Finland by morphology and tumor location.

Material And Methods: Data on 4730 malignant glioma patients were obtained from case notifications to the nationwide, population-based Finnish Cancer Registry (FCR), and less detailed data on 3590 patients up to 2016. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2019.1
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http://dx.doi.org/10.1080/0284186X.2019.1603396DOI Listing
April 2019
2 Reads

Prognostic Value of O-(2-[F]Fluoroethyl)-L-Tyrosine PET/CT in Newly Diagnosed WHO 2016 Grade II and III Glioma.

Mol Imaging Biol 2019 Apr 11. Epub 2019 Apr 11.

Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany.

Purpose: The use of [F]fluoroethyl)-L-tyrosine ([F]FET) positron emission tomography/computed tomography (PET/CT) has proven valuable in brain tumor management. This study aimed to investigate the prognostic value of radiotracer uptake in newly diagnosed grade II or III gliomas according to the current 2016 World Health Organization (WHO) classification.

Procedures: A total of 35 treatment-naive patients (mean age, 48 ± 17 years) with histologically proven WHO grade II or III gliomas as defined by the current 2016 WHO classification were included. Read More

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http://link.springer.com/10.1007/s11307-019-01357-y
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http://dx.doi.org/10.1007/s11307-019-01357-yDOI Listing
April 2019
2 Reads

An update on the central nervous system manifestations of tuberous sclerosis complex.

Acta Neuropathol 2019 Apr 11. Epub 2019 Apr 11.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.

The autosomal dominant disorder tuberous sclerosis complex (TSC) is characterized by an array of manifestations both within and outside of the central nervous system (CNS), including hamartomas and other malformations. TSC is caused by mutations in the TSC1 or TSC2 gene resulting in activation of the mechanistic target of rapamycin (mTOR) signaling pathway. Study of TSC has shed light on the critical role of the mTOR pathway in neurodevelopment. Read More

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http://link.springer.com/10.1007/s00401-019-02003-1
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http://dx.doi.org/10.1007/s00401-019-02003-1DOI Listing
April 2019
4 Reads

Microsurgical management of fourth ventricle astrocytoma via the median suboccipital keyhole approach: A review of 12 cases.

Authors:
Li Guowei Lan Qing

World Neurosurg 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurosurgery, the Second Affiliated Hospital of Soochow University, SanXiang Road 1005. Suzhou 215004. China. Electronic address:

Objective: To investigate the clinical effect and surgical techniques of fourth ventricle astrocytoma resection through the median suboccipital keyhole approach.

Methods: Twelve patients received tumor resection through the median suboccipital keyhole approach in our department. A 4-cm median suboccipital excision starting 1 cm under the foramen magnum region and directed vertically upward was applied. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.156DOI Listing

A young man with visual disturbances and a mild headache.

JAAPA 2018 Apr;31(4):1-3

Jerimiah D. Walker is an emergency medicine PA resident at the William Beaumont Army Medical Center in Fort Bliss, Tex. The author has disclosed no potential conflicts of interest, financial or otherwise. The views expressed in this article are those of the author and do not reflect the official policy of William Beaumont Army Medical Center, the Department of the Army, or the US government.

Headaches are common presenting complaints in EDs throughout the United States. Most are benign and should be treated symptomatically. Certain historical risk factors and physical examination findings increase the likelihood of a secondary cause of headache and warrant further investigation with neuroimaging. Read More

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http://dx.doi.org/10.1097/01.JAA.0000531047.74384.8eDOI Listing

A radiomics nomogram may improve the prediction of IDH genotype for astrocytoma before surgery.

Eur Radiol 2019 Apr 10. Epub 2019 Apr 10.

Department of Radiology, The first hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China.

Objectives: To develop and validate a radiomics nomogram to preoperative prediction of isocitrate dehydrogenase (IDH) genotype for astrocytomas, which might contribute to the pretreatment decision-making and prognosis evaluating.

Methods: One hundred five astrocytomas (Grades II-IV) with contrast-enhanced T1-weighted imaging (CE-T1WI), T2 fluid-attenuated inversion recovery (T2FLAIR), and apparent diffusion coefficient (ADC) map were enrolled in this study (training cohort: n = 74; validation cohort: n = 31). IDH1/2 genotypes were determined using Sanger sequencing. Read More

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http://dx.doi.org/10.1007/s00330-019-06056-4DOI Listing

Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations.

Brain Tumor Pathol 2019 Apr 10. Epub 2019 Apr 10.

Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan.

We report four cases of high-grade astrocytoma with a BRAF V600E mutation, ATRX inactivation, and CDKN2A/B homozygous deletion. Children to young adults aged 3-46 presented with a well demarcated contrast-enhancing mass in the supratentorial area. Pathological examination revealed packed growth of short spindle to round polygonal cells including some pleomorphic cells. Read More

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http://link.springer.com/10.1007/s10014-019-00344-z
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http://dx.doi.org/10.1007/s10014-019-00344-zDOI Listing
April 2019
2 Reads

Applications of molecular neuro-oncology - a review of diffuse glioma integrated diagnosis and emerging molecular entities.

Diagn Pathol 2019 Apr 9;14(1):29. Epub 2019 Apr 9.

Knight Diagnostic Laboratories and Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, USA.

Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on morphologic and molecular features, including gene mutations, chromosomal copy number alterations, and gene rearrangements. In 2016, the World Health Organization provided guidelines for making an integrated diagnosis that incorporates both morphologic and molecular features in a subset of brain tumors. Read More

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http://dx.doi.org/10.1186/s13000-019-0802-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457044PMC
April 2019
1 Read

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.

Int J Mol Sci 2019 Apr 5;20(7). Epub 2019 Apr 5.

Department of Stress Response Science, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.

Carnosic acid (CA) is a phytochemical found in some dietary herbs, such as L., and possesses antioxidative and anti-microbial properties. We previously demonstrated that CA functions as an activator of nuclear factor, erythroid 2 (NF-E2)-related factor 2 (Nrf2), an oxidative stress-responsive transcription factor in human and rodent cells. Read More

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http://dx.doi.org/10.3390/ijms20071706DOI Listing
April 2019
6 Reads

The molecular landscape of adult diffuse gliomas and relevance to clinical trials.

Oncotarget 2019 Mar 5;10(19):1758-1759. Epub 2019 Mar 5.

Patrick J. Cimino: Department of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, WA, USA.

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http://dx.doi.org/10.18632/oncotarget.26750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443000PMC
March 2019
2 Reads

Characteristics, survival and incidence rates and trends of pilocytic astrocytoma in children in the United States; SEER-based analysis.

Authors:
Mohamed A Tabash

J Neurol Sci 2019 May 29;400:148-152. Epub 2019 Mar 29.

Christian Hospital Quakenbrück, Academic Teaching Hospital of the University of Oldenburg, 49610 Quakenbrück, Germany. Electronic address:

Introduction: Pilocytic astrocytoma (PA) is a neurological neoplasm and a common neurological tumor among children. No recent reports have studied the recent demographic characteristics of PA cases in the US.

Methodology: We used the Surveillance, Epidemiology, and End Results (SEER) Program to retrieve data on children diagnosed with PA between 2000 and 2015. Read More

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http://dx.doi.org/10.1016/j.jns.2019.03.028DOI Listing
May 2019
1 Read

Immune Phenotype Correlates With Survival in Patients With GBM Treated With Standard Temozolomide-based Therapy and Immunotherapy.

Anticancer Res 2019 Apr;39(4):2043-2051

Institute of Communication and Computer Systems, School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.

Background/aim: The need for more effective treatment modalities that can improve the clinical outcome of patients with glioblastoma multiforme remains imperative. Dendritic cell vaccination is a fast-developing treatment modality, currently under exploration. Functional immune cell subpopulations may play a role in the final outcome. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13315DOI Listing
April 2019
5 Reads

Magnetic resonance imaging and proton magnetic resonance spectroscopy for differentiating between enhanced gliomas and malignant lymphomas.

World Neurosurg 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan.

Objective: Although the treatment strategies for malignant lymphomas and gliomas differ, it is usually difficult to preoperatively distinguish between the two. Magnetic resonance spectroscopy (MRS) was recently reported to be useful for preoperative diagnoses; however, MRS data analysis using LCModel, which is a quantitative and objective method, was performed in only a few of the existing reports.

Methods: The clinical characteristics, conventional magnetic resonance imaging findings and MRS parameters using LCModel were evaluated to identify the factors that can help distinguish between malignant lymphomas and enhanced gliomas. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.261DOI Listing
April 2019
7 Reads

Prognostic Significance of Anatomic Origin and Evaluation of Survival Statistics of Astrocytoma Patients-a Tertiary Experience.

Indian J Surg Oncol 2019 Mar 30;10(1):55-60. Epub 2018 Oct 30.

1Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State 500046 India.

Astrocytoma constitutes the most noted malignancies of the central nervous system with worse clinical outcomes in grade IV astrocytoma or glioblastoma multiforme. Owing to poor clinical outcomes with existing therapeutic regime, there is a need to revisit the initial course of treatment. Statistical information of clinicopathological parameters could be used to understand the spread of disease and, in turn, to formulate updated treatment management. Read More

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http://link.springer.com/10.1007/s13193-018-0820-0
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http://dx.doi.org/10.1007/s13193-018-0820-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414575PMC
March 2019
3 Reads

Pilomyxoid astrocytomas: a short review.

Brain Tumor Pathol 2019 Apr 3. Epub 2019 Apr 3.

Neuropathology Division, Department of Pathology, UCSF School of Medicine, Moffitt, M551C, University of California, 505 Parnassus Avenue, Box 0102, San Francisco, CA, 94143, USA.

Pilomyxoid astrocytoma is a variant of pilocytic astrocytoma and the clinical, histological and molecular data point to a very close relationship as well as a more aggressive biological behavior for the former. WHO 2016 classification does not provide a specific grade for these neoplasms, but there is sufficient evidence in the literature that pilomyxoid astrocytoma has slightly worse prognosis than typical pilocytic astrocytoma. There is increasing evidence that in addition to the MAPK pathway alterations, pilomyxoid astrocytomas harbor genetic alterations that distinguish them from typical pilocytic astrocytoma. Read More

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http://link.springer.com/10.1007/s10014-019-00343-0
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http://dx.doi.org/10.1007/s10014-019-00343-0DOI Listing
April 2019
4 Reads

Synthesis and cytotoxicity of octahydroepoxyisoindole-7-carboxylic acids and norcantharidin-amide hybrids as norcantharidin analogues.

ChemMedChem 2019 Apr 1. Epub 2019 Apr 1.

The University of Newcastle, Department of Chemistry, University Drive, Callaghan, 2308, Newcastle, AUSTRALIA.

Octahydroepoxyisoindole analogues (7a-n) of norcantharidin were accessed through a Diels-Alder reaction of an amine substituted furan with maleic anhydride and subsequent reduction of the bicycle[2.2.1]heptane olefin. Read More

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http://dx.doi.org/10.1002/cmdc.201900180DOI Listing
April 2019
1 Read

Subpial Cervical Subependymoma: Report of an Unusual Tumor with Review of Literature.

Asian J Neurosurg 2019 Jan-Mar;14(1):329-331

Department of Neurosurgery, SGPGIMS, Lucknow, Uttar Pradesh, India.

Subependymoma is rare benign neoplasm (World Health Organization Grade I) usually found in the 4 ventricle and lateral ventricles. They were first described by Boykin as a separate entity in 1954. Subependymoma constitutes only 1%-2% of spinal ependymal tumors. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_225_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417354PMC
April 2019
1 Read

Adult Pilomyxoid Astrocytoma with Hemorrhage in an Atypical Location.

Asian J Neurosurg 2019 Jan-Mar;14(1):300-303

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Pilomyxoid astrocytomas (PMAs) are generally seen in young children and tend to occur in the hypothalamic-chiasmatic region. Their presence in other parts of the brain in the nonpediatric age group is uncommon. In addition, hemorrhage in such low-grade tumors is an occasional event. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_164_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417295PMC
April 2019
2 Reads

Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females.

Eur J Hum Genet 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurosurgery, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, 5, 16147, Genoa, Italy.

De novo DDX3X variants account for 1-3% of syndromic intellectual disability (ID) in females and have been occasionally reported in males. Furthermore, somatic DDX3X variants occur in several aggressive cancers, including medulloblastoma. We report three unrelated females with severe ID, dysmorphic features, and a common brain malformative pattern characterized by malformations of cortical development, callosal dysgenesis, basal ganglia anomalies, and midbrain-hindbrain malformations. Read More

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http://dx.doi.org/10.1038/s41431-019-0392-7DOI Listing

fusion in a low-grade glioma with distinctive morphology and unexpected aggressive behavior.

Cold Spring Harb Mol Case Stud 2019 Apr 1;5(2). Epub 2019 Apr 1.

Department of Pathology, University of Iowa, Iowa City, Iowa 52242, USA.

A 52-yr-old man was found to have a 6.6-cm left frontotemporal mass. Biopsy revealed a low-grade astrocytic neoplasm with significant infiltration and an unusual morphologic appearance. Read More

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http://dx.doi.org/10.1101/mcs.a003855DOI Listing
April 2019
2 Reads

Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival.

Sci Rep 2019 Apr 1;9(1):5406. Epub 2019 Apr 1.

Laboratory of Molecular Neurooncology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu str. 4, Kaunas, LT-50161, Lithuania.

Gliomas are heterogeneous, primary brain tumours that originate from glial cells. The main type of gliomas is astrocytomas. There are four grades (I-IV) of astrocytoma malignancy. Read More

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http://dx.doi.org/10.1038/s41598-019-41974-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443939PMC
April 2019
1 Read

Health Related Quality of Life in Adult Low and High-Grade Glioma Patients Using the National Institutes of Health Patient Reported Outcomes Measurement Information System (PROMIS) and Neuro-QOL Assessments.

Front Neurol 2019 15;10:212. Epub 2019 Mar 15.

Department of Neurosurgery, University of Michigan, Ann Arbor, MI, United States.

Health related quality of life (HRQOL) measures have become increasingly important in the management of glioma patients in both research and clinical practice settings. Functional impairment is common in low-grade and high-grade glioma patients as the disease has both oncological and neurological manifestations. Natural disease history as well as medical or surgical treatment can negatively influence HRQOL. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00212
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http://dx.doi.org/10.3389/fneur.2019.00212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428723PMC
March 2019
5 Reads

Prognostic Role of Chicken Ovalbumin Upstream Promoter Transcription Factor II in Isocitrate Dehydrogenase-Mutant Glioma with 1p19q Co-Deletion.

J Mol Neurosci 2019 Mar 30. Epub 2019 Mar 30.

School of Clinical Medicine and Department of Neurosurgery, Yuquan Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Background: Chicken ovalbumin upstream promoter transcription factor II is known to play a crucial role in the tumor microenvironment. However, the role of NR2F2 in gliomas is unknown.

Methods: The genomic and clinical data of 530 cases of lower grade gliomas (LGGs) patients and 167 cases of glioblastoma (GBM) patients in The Cancer Genome Atlas (TCGA) were extracted for analysis. Read More

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http://dx.doi.org/10.1007/s12031-019-01281-4DOI Listing
March 2019
5 Reads

Molecular genetics and therapeutic targets of pediatric low-grade gliomas.

Brain Tumor Pathol 2019 Mar 30. Epub 2019 Mar 30.

Department of Neurosurgery, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.

Pediatric low-grade gliomas (PLGGs) have relatively favorable prognosis and some resectable PLGGs, such as cerebellar pilocytic astrocytoma, can be cured by surgery alone. However, many PLGG cases are unresectable and some of them undergo tumor progression. Therefore, a multidisciplinary approach is necessary to treat PLGG patients. Read More

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http://dx.doi.org/10.1007/s10014-019-00340-3DOI Listing
March 2019
3 Reads
2.281 Impact Factor

Targeted copy number analysis outperforms histological grading in predicting patient survival for WHO grade II/III IDH-mutant astrocytomas.

Neuro Oncol 2019 Mar 28. Epub 2019 Mar 28.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.

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http://dx.doi.org/10.1093/neuonc/noz052DOI Listing

The effects of cucurbitacin E on GADD45β-trigger G2/M arrest and JNK-independent pathway in brain cancer cells.

J Cell Mol Med 2019 Mar 25. Epub 2019 Mar 25.

Department of General Surgery, Tainan Sin Lau Hospital, The Presbyterian Church in Taiwan, Tainan, Taiwan.

Cucurbitacin E (CuE), an active compound of the cucurbitacin family, possesses a variety of pharmacological functions and chemotherapy potential. Cucurbitacin E exhibits inhibitory effects in several types of cancer; however, its anticancer effects on brain cancer remain obscure and require further interpretation. In this study, efforts were initiated to inspect whether CuE can contribute to anti-proliferation in human brain malignant glioma GBM 8401 cells and glioblastoma-astrocytoma U-87-MG cells. Read More

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http://dx.doi.org/10.1111/jcmm.14250DOI Listing
March 2019
1 Read

Holocord Pilocytic Astrocytoma in an Adult: A Rare Case Report and Review of the Literature.

World Neurosurg 2019 Mar 19. Epub 2019 Mar 19.

Memorial Hospital, Neurosurgery Clinic, Ankara, Turkey.

Background: Intramedullary glial neoplasms affecting the entire spinal cord from the cervicomedullary junction to conus medullaris are termed 'holocord tumors'. Pilocytic astrocytomas are relatively uncommon tumors forming holocord involvement. Hitherto 24 holocord astrocytoma cases were reported in the literature. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.103DOI Listing
March 2019
1 Read
2.417 Impact Factor

Proliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region.

J Neurosurg 2019 Mar 22:1-8. Epub 2019 Mar 22.

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and China National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute for Brain Disorders and Beijing Key Laboratory of Brain Tumor, Beijing, China; and.

OBJECTIVEThe aim of this study was to investigate the relationship between extent of resection (EOR) and survival in terms of clinical, molecular, and radiological factors in high-grade astrocytoma (HGA).METHODSClinical and radiological data from 585 cases of molecularly defined HGA were reviewed. In each case, the EOR was evaluated twice: once according to contrast-enhanced T1-weighted images (CE-T1WI) and once according to fluid attenuated inversion recovery (FLAIR) images. Read More

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http://dx.doi.org/10.3171/2018.12.JNS182775DOI Listing
March 2019
2 Reads

The miR155HG/miR-185/ANXA2 loop contributes to glioblastoma growth and progression.

J Exp Clin Cancer Res 2019 Mar 21;38(1):133. Epub 2019 Mar 21.

Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.

Background: Glioblastoma multiforme (GBM) is the most common and aggressive form of astrocytoma among adult brain tumors. Multiple studies have shown that long non-coding RNAs (lncRNAs) play important roles in acting as molecular sponge for competing with microRNAs (miRNAs) to regulate downstream molecules in tumor progression. We previously reported that miR155 host gene (miR155HG), an lncRNA, and its derivative miR-155 promote epithelial-to-mesenchymal transition in glioma. Read More

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http://dx.doi.org/10.1186/s13046-019-1132-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427903PMC
March 2019
1 Read

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.

Nat Commun 2019 03 19;10(1):1262. Epub 2019 Mar 19.

Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.

Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to assess H3K27M effects in vitro and in vivo. We find that whereas H3K27me3 and H3K27me2 are normally deposited by PRC2 across broad regions, their deposition is severely reduced in H3. Read More

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http://dx.doi.org/10.1038/s41467-019-09140-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425035PMC
March 2019
5 Reads
10.742 Impact Factor

Gliomatosis Cerebri Among Children and Adolescents: An Individual-Patient Data Meta-analysis of 182 Patients.

J Child Neurol 2019 Mar 19:883073819836551. Epub 2019 Mar 19.

1 Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background:: Gliomatosis cerebri is a rare but fatal widespread infiltrating central nervous system tumor. We aimed to describe diagnostic and prognostic features of gliomatosis cerebri among children and adolescents.

Methods:: We conducted a systematic literature review for published case reports and case series on patients with histologically confirmed gliomatosis cerebri and extracted data on an individual patient level for those aged 0-18 years. Read More

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http://dx.doi.org/10.1177/0883073819836551DOI Listing
March 2019
5 Reads

Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma.

Neuro Oncol 2019 Mar;21(4):537-546

Division of Hematology/Oncology, Ann & Robert H. Lurie Children's Hospital of Chicago and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: Gene-mediated cytotoxic immunotherapy (GMCI) is a tumor-specific immune stimulatory strategy implemented through local delivery of aglatimagene besadenovec (AdV-tk) followed by anti-herpetic prodrug. GMCI induces T-cell dependent tumor immunity and synergizes with radiotherapy. Clinical trials in adult malignant gliomas demonstrated safety and potential efficacy. Read More

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http://dx.doi.org/10.1093/neuonc/noy202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422437PMC
March 2019
1 Read

Endoresection utilizing pars plana vitrectomy for benign and malignant intraocular tumors.

Curr Opin Ophthalmol 2019 May;30(3):151-158

Tennessee Retina, Nashville, TN, USA.

Purpose Of Review: Endoresection of intraocular tumors is a complicated procedure utilizing pars plana vitrectomy techniques. Though it has potential downsides and complications, there is potential for this technique in the treatment of malignant and benign intraocular tumors.

Recent Findings: Endoresection has been utilized in some form for the last three decades, but recent advances in vitreoretinal surgery have improved the technique. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000561DOI Listing
May 2019
1 Read

Is Schimmelpenning Syndrome Associated with Intracranial Tumors? A Case Report.

Pediatr Neurosurg 2019 Mar 15:1-6. Epub 2019 Mar 15.

Division of Pediatric Neurological Surgery, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Schimmelpenning syndrome is a rare, well-defined constellation of clinical phenotypes associated with the presence of nevus sebaceous and multisystem abnormalities most commonly manifested as cerebral, ocular, and skeletal defects [1]. A single nucleotide mutation in the HRAS or KRAS genes resulting in genetic mosaicism is responsible for the clinical manifestations of this syndrome in the majority of cases. We report a case of an adolescent boy with Schimmelpenning syndrome with a multifocal pilocytic astrocytoma. Read More

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http://dx.doi.org/10.1159/000497149DOI Listing

Arterial Spin Labeling for Glioma Grade Discrimination: Correlations with IDH1 Genotype and 1p/19q Status.

Transl Oncol 2019 May 15;12(5):749-756. Epub 2019 Mar 15.

Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou 510060, China. Electronic address:

Since accurate grading of gliomas has important clinical value, the aim of this study is to evaluate the diagnostic efficacy of perfusion values derived from arterial spin labeling (ASL) to grade gliomas. In addition, the correlation between perfusion and isocitrate dehydrogenase 1 (IDH1) genotypes and chromosome arms 1p and 19q (1p/19q) status of gliomas was assessed. A total of 52 cases of supratentorial gliomas in adults who received ASL imaging were enrolled in this retrospective study. Read More

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http://dx.doi.org/10.1016/j.tranon.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423366PMC
May 2019
3 Reads

c-Met Expression Is a Useful Marker for Prognosis Prediction in IDH-Mutant Lower-Grade Gliomas and IDH-Wildtype Glioblastomas.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan.

Objective: c-Met has been shown to be associated with tumor growth in several human cancers. This study aims to evaluate the correlation between the c-Met expression and histopathologic/clinical characteristics.

Methods: A total of 153 patients with histologically defined World Health Organization grade II-IV diffuse astrocytic and oligodendroglial tumors were analyzed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.040DOI Listing
March 2019
3 Reads

Newly-diagnosed Optic Pathway Glioma During Pregnancy: A Case Report.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas, USA. Electronic address:

Background: Optic pathway gliomas (OPGs) are relatively rare, and their presentation after the first decade of life is even less common. While many treatment options exist, surgery is typically reserved for tumors significantly compressing surrounding structures. Pregnancy can complicate the management of these tumors, as fetal developmental considerations limit the ways in which they are imaged and treated. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.207DOI Listing
March 2019
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Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis.

Acta Neuropathol Commun 2019 Mar 15;7(1):42. Epub 2019 Mar 15.

Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

Astroblastoma (AB) is a rare CNS tumor demonstrating abundant astroblastomatous pseudorosettes. Its molecular features have not been comprehensively studied and its status as a tumor entity is controversial. We analyzed a cohort of 27 histologically-defined ABs using DNA methylation profiling, copy number analysis, FISH and site-directed sequencing. Read More

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http://dx.doi.org/10.1186/s40478-019-0689-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419470PMC
March 2019
1 Read

Aquaporin-4 Expression Patterns in Glioblastoma Pre-Chemoradiation and at Time of Suspected Progression.

Cancer Invest 2019 15;37(2):67-72. Epub 2019 Mar 15.

c Department of Oncology , Johns Hopkins University , Baltimore , MD , USA.

There has been controversy about the presence and potential role of aquaporin-4 (AQP4) in glioblastoma (GBM). We analyzed tissue from 22 patients with newly-diagnosed GBM as well as matching tissue from 17 of these cases who underwent repeat resection for suspected recurrence and performed immunohistochemical analysis for AQP-4 expression. While some degree of AQP4 expression was detected in all 22 cases (39 samples), there was no clear relationship between staining pattern and disease status (active versus inactive GBM) between baseline and time of repeat biopsy. Read More

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http://dx.doi.org/10.1080/07357907.2018.1564927DOI Listing
March 2019
3 Reads

Comparable Genomic Copy Number Aberrations Differ across Astrocytoma Malignancy Grades.

Int J Mol Sci 2019 Mar 12;20(5). Epub 2019 Mar 12.

Department for Functional Genomics, Center for Translational and Clinical Research, University of Zagreb, School of Medicine and University Hospital Center Zagreb, Šalata 2, 10000 Zagreb, Croatia.

A collection of intracranial astrocytomas of different malignancy grades was analyzed for copy number aberrations (CNA) in order to identify regions that are driving cancer pathogenesis. Astrocytomas were analyzed by Array Comparative Genomic Hybridization (aCGH) and bioinformatics utilizing a Bioconductor package, Genomic Identification of Significant Targets in Cancer (GISTIC) 2.0. Read More

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http://dx.doi.org/10.3390/ijms20051251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429132PMC
March 2019
3 Reads