41,012 results match your criteria Astrocytoma


Racial/ethnic Disparities and Survival in Pediatrics with Gliomas Based on the Surveillance Epidemiology and End Results Database in the United States.

World Neurosurg 2020 May 31. Epub 2020 May 31.

Department of Biochemistry and Molecular Biology, College of Basic Medical, Navy Medical University, Shanghai, 200433, P.R.China. Electronic address:

Background: Gliomas are the most common type of primary central nervous system tumor for both children and adults. But the influence of racial/ethnic disparities on the survival of children with gliomas has not been fully evaluated yet.

Methods: Baseline characteristics of patients, including gender, year of diagnosis, surgery, grade, radiation, histology and races, were collected. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.224DOI Listing

Glioblastoma multiforme that unusually present with radiographic dural tails: Questioning the diagnostic paradigm with a rare case report.

Radiol Case Rep 2020 Jul 8;15(7):1087-1090. Epub 2020 May 8.

Icahn School of Medicine at Mount Sinai-Elmhurst Hospital, Queens, New York, NY.

Glioblastoma multiforme (GBM) is both the most common as well as one of the most aggressive primary intracerebral tumors. It classically presents on magnetic resonance imaging as a heterogeneous ring-enhancing lesion in the brain parenchyma with central necrosis. This type of neoplasm can also rarely present, however, as a mass with meningeal attachment and radiographic evidence of a dural tail, which was until recently thought to be specific to meningiomas. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256235PMC

Secondary glioblastoma metastasis outside the central nervous system in a young HIV-infected patient.

Ther Adv Med Oncol 2020 18;12:1758835920923432. Epub 2020 May 18.

Instituto Estadual do Cérebro Paulo Niemeyer, Rua do Rezende 156, Rio de Janeiro, RJ, 20231-092, Brazil.

Glioblastoma is the most common adult primary brain tumor that occurs in the central nervous system and is characterized by rapid growth and diffuse invasiveness with respect to the adjacent brain parenchyma, which renders surgical resection inefficient. Although it is a highly infiltrative tumor, it is rarely disseminated beyond the central nervous system, wherein extracranial metastasis is a unique but rare manifestation of this kind of tumor. It is very common for acquired immunodeficiency syndrome (AIDS) patients to be infected with the human immunodeficiency virus (HIV), which suggests that a possible association between HIV infection and tumor development exists. Read More

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http://dx.doi.org/10.1177/1758835920923432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238297PMC

Occurrence of Glioma in Pregnant Patients: An Institutional Case Series and Review of the Literature.

Anticancer Res 2020 Jun;40(6):3453-3457

Department of Neurology & Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, U.S.A.

Background/aim: Gliomas present a uniquely challenging clinical situation in the context of pregnancy, with no standard recommendations. This case series aimed to describe the treatment regimen and outcomes of five pregnant patients with gliomas.

Patients And Methods: This is a retrospective study. Read More

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http://dx.doi.org/10.21873/anticanres.14331DOI Listing

Is Next-Generation Sequencing Alone Sufficient to Reliably Diagnose Gliomas?

J Neuropathol Exp Neurol 2020 Jun 1. Epub 2020 Jun 1.

From the Department of Pathology, Northwestern University, Chicago, Illinois.

The power and widespread use of next-generation sequencing (NGS) in surgical neuropathology has raised questions as to whether NGS might someday fully supplant histologic-based examination. We therefore sought to determine the feasibility of relying on NGS alone for diagnosing infiltrating gliomas. A total of 171 brain lesions in adults, all of which had been analyzed by GlioSeq NGS, comprised the study cohort. Read More

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http://dx.doi.org/10.1093/jnen/nlaa044DOI Listing

Dysregulation of the MMP/TIMP Proteolytic System in Subependymal Giant Cell Astrocytomas in Patients With Tuberous Sclerosis Complex: Modulation of MMP by MicroRNA-320d In Vitro.

J Neuropathol Exp Neurol 2020 May 29. Epub 2020 May 29.

From the Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.

Tuberous sclerosis complex (TSC), a rare genetic disorder caused by a mutation in the TSC1 or TSC2 gene, is characterized by the growth of hamartomas in several organs. This includes the growth of low-grade brain tumors, known as subependymal giant cell astrocytomas (SEGA). Previous studies have shown differential expression of genes related to the extracellular matrix in SEGA. Read More

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http://dx.doi.org/10.1093/jnen/nlaa040DOI Listing

Cancer diagnostic profile in children with structural birth defects: An assessment in 15,000 childhood cancer cases.

Cancer 2020 May 29. Epub 2020 May 29.

Department of Medicine, Baylor College of Medicine, Houston, Texas.

Background: Birth defects are established risk factors for childhood cancer. Nonetheless, cancer epidemiology in children with birth defects is not well characterized.

Methods: Using data from population-based registries in 4 US states, this study compared children with cancer but no birth defects (n = 13,111) with children with cancer and 1 or more nonsyndromic birth defects (n = 1616). Read More

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http://dx.doi.org/10.1002/cncr.32982DOI Listing

Stereotactic laser ablation for subependymal giant cell astrocytomas: personal experience and review of the literature.

Childs Nerv Syst 2020 May 28. Epub 2020 May 28.

Pediatric Neurosurgery, Dell Children's Medical Center, Department of Neurosurgery, The University of Texas at Austin Dell Medical School, Austin, TX, USA.

Purpose: Subependymal giant cell astrocytomas (SEGAs) are rare tumors typically found in tuberous sclerosis patients. They typically grow in the region of the foramen of Monro and can occlude it, leading to hydrocephalus. Currently, gross total resection is the standard of care, with low rates of recurrence but high rates of complication, especially with larger lesions. Read More

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http://dx.doi.org/10.1007/s00381-020-04638-yDOI Listing

TSC2 pathogenic variants are predictive of severe clinical manifestations in TSC infants: results of the EPISTOP study.

Genet Med 2020 May 28. Epub 2020 May 28.

Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Purpose: To perform comprehensive genotyping of TSC1 and TSC2 in a cohort of 94 infants with tuberous sclerosis complex (TSC) and correlate with clinical manifestations.

Methods: Infants were enrolled at age <4 months, and subject to intensive clinical monitoring including electroencephalography (EEG), brain magnetic resonance imaging (MRI), and neuropsychological assessment. Targeted massively parallel sequencing (MPS), genome sequencing, and multiplex ligation-dependent probe amplification (MLPA) were used for variant detection in TSC1/TSC2. Read More

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http://dx.doi.org/10.1038/s41436-020-0823-4DOI Listing

Heme Oxygenase-1 in Central Nervous System Malignancies.

J Clin Med 2020 May 21;9(5). Epub 2020 May 21.

Department of Drug Science, Biochemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.

Central nervous system tumors are the most common pediatric solid tumors and account for 20%-25% of all childhood malignancies. Several lines of evidence suggest that brain tumors show altered redox homeostasis that triggers the activation of various survival pathways, leading to disease progression and chemoresistance. Among these pathways, heme oxygenase-1 (HO-1) plays an important role. Read More

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http://dx.doi.org/10.3390/jcm9051562DOI Listing

Cancer incidence and spectrum among children with genetically confirmed Beckwith-Wiedemann spectrum in Germany: a retrospective cohort study.

Br J Cancer 2020 May 26. Epub 2020 May 26.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, 30625, Germany.

Background: Beckwith-Wiedemann syndrome (BWS) is a cancer predisposition syndrome caused by defects on chromosome 11p15.5. The quantitative cancer risks in BWS patients depend on the underlying (epi)genotype but have not yet been assessed in a population-based manner. Read More

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http://dx.doi.org/10.1038/s41416-020-0911-xDOI Listing

Surgical treatment of low-grade brain tumors associated with epilepsy.

Int Rev Neurobiol 2020 13;151:171-183. Epub 2020 May 13.

Epilepsy Center, Guangdong Sanjiu Brain Hospital, Guangzhou, China. Electronic address:

Objective: To explore the strategy of surgical treatment of low-grade brain tumors associated with epilepsy.

Methods: Clinical data of 158 patients with low-grade brain tumors were collected from January 2011 to December 2017 in Guangdong Sanjiu brain hospital. All patients received Preoperative evaluation. Read More

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http://dx.doi.org/10.1016/bs.irn.2020.03.021DOI Listing

Fluorescein-guided surgery for spinal gliomas: Analysis of 220 consecutive cases.

Int Rev Neurobiol 2020 13;151:139-154. Epub 2020 May 13.

Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. Electronic address:

Objective: Sodium fluorescein (FL) is widely used as a fluorescent tracer for brain tumor resection. However, FL-guided resection of spinal gliomas has been reported only occasionally. To evaluate the safety, characteristics, and usefulness of FL-guided surgery in the resection of spinal glioma. Read More

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http://dx.doi.org/10.1016/bs.irn.2020.03.004DOI Listing

Coumarins modulate the anti-glioma properties of temozolomide.

Eur J Pharmacol 2020 May 21:173207. Epub 2020 May 21.

Department of Functional Anatomy and Cytobiology, Maria Curie-Sklodowska University, Akademicka 19, 20-033, Lublin, Poland. Electronic address:

In the recent years, coumarin bioactive compounds have been identified to posess anticancer properties. Therefore, the aim of the present study was to investigate for the first time the efficacy of osthole, umbelliferone, esculin, and 4-hydroxycoumarin, alone and in combination with Temozolomide, in the elimination of deadly brain tumors, anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM) cells via programmed death. Our results indicated that osthole, umbelliferone, esculin, and 4-hydroxycoumarin initiated mainly apoptosis in the T98G and MOGGCCM cells. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173207DOI Listing

New insight into nucleo α-amino acids - Synthesis and SAR studies on cytotoxic activity of β-pyrimidine alanines.

Bioorg Chem 2020 May 15;100:103864. Epub 2020 May 15.

Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland. Electronic address:

Three series of the β-pyrimidine alanines, including willardiine - a naturally occurring amino acid, were prepared from the l-serine-derived sulfamidates. Compounds 3b, 4a and 4b demonstrated antiproliferative activity toward the studied cancer cell lines, albeit the effect of these compounds on human brain astrocytoma MOG-G-CCM cells was more significant than on human neuroblastoma SK-N-AS cells. The cytosine analog of willardiine, compound 4b, reduced viability of MOG-G-CCM cells with EC = 36 ± 2 μM, more effectively than AMPA antagonist GYKI 52466. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103864DOI Listing

GAMMA-LINOLENIC ACID ALTERS MIGRATION, PROLIFERATION AND APOPTOSIS IN HUMAN AND RAT GLIOBLASTOMA CELLS.

Prostaglandins Other Lipid Mediat 2020 May 18:106452. Epub 2020 May 18.

Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of São Paulo, 1374, Prof. Lineu Prestes Av. 05508-900, São Paulo, SP, Brazil. Electronic address:

Glioblastoma multiforme (GBM) is the most malignant astrocytoma, the main treatments consist of surgical resection followed by radiotherapy and chemotherapy. Patients, after diagnosed, have a survival rate of one year. GBM cells have an invasive, proliferative and migratory characteristic, also they do not respond properly for usual cancer treatment (radiotherapy, chemotherapy). Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2020.106452DOI Listing

Advantage of high b value diffusion-weighted imaging for differentiation of common pediatric brain tumors in posterior fossa.

Eur J Radiol 2020 May 5;128:108983. Epub 2020 May 5.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, Japan. Electronic address:

Purpose: The pediatric posterior fossa (PF) brain tumors with higher frequencies are embryonal tumors (ET), ependymal tumors (EPN) and pilocytic astrocytomas (PA), however, it is often difficult to make a differential diagnosis among them with conventional MRI. The ADC calculated from DWI could be beneficial for diagnostic work up.

Method: We acquired DWI at b = 1000 and 4000(s/mm). Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.108983DOI Listing
May 2020
2.369 Impact Factor

External beam radiation dose escalation for high grade glioma.

Cochrane Database Syst Rev 2020 05 21;5:CD011475. Epub 2020 May 21.

Department of Radiation Oncology, University of Toronto, Toronto, Canada.

Background: This is an updated version of the original Cochrane Review published in Issue 8, 2016. High grade glioma (HGG) is a rapidly growing brain tumour in the supporting cells of the nervous system, with several subtypes such as glioblastoma (grade IV astrocytoma), anaplastic (grade III) astrocytoma and anaplastic (grade III) oligodendroglioma. Studies have investigated the best strategy to give radiation to people with HGG. Read More

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http://dx.doi.org/10.1002/14651858.CD011475.pub3DOI Listing

Sensitive Detection and Conjoint Analysis of Promoter Methylation by Conjugated Polymers for Differential Diagnosis and Prognosis of Glioma.

ACS Appl Mater Interfaces 2020 May 21. Epub 2020 May 21.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

Glioma is the most common primary tumor in the central nervous system (CNS) with the worst prognosis. Accurate pathological diagnosis has always been a challenge for optimal management of glioma. Promoter methylation is an important mechanism of epigenetic silencing tumor-suppressor genes and a potential biomarker for differential diagnosis and prognosis. Read More

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http://dx.doi.org/10.1021/acsami.0c03218DOI Listing

The clinical significance of the T2-FLAIR mismatch sign in grade II and III gliomas: a population-based study.

BMC Cancer 2020 May 20;20(1):450. Epub 2020 May 20.

Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: The T2-FLAIR mismatch sign is an imaging finding highly suggestive of isocitrate dehydrogenase mutated (IDH-mut) 1p19q non-codeleted (non-codel) gliomas (astrocytomas). In previous studies, it has shown excellent specificity but limited sensitivity for IDH-mut astrocytomas. Whether the mismatch sign is a marker of a clinically relevant subtype of IDH-mut astrocytomas is unknown. Read More

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http://dx.doi.org/10.1186/s12885-020-06951-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238512PMC

Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.

Virulence 2020 12;11(1):537-553

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.

Enterovirus 71 (EV71) infection causes hand, foot, and mouth disease (HFMD), and even fatal neurological complications. However, the mechanisms underlying EV71 neurological pathogeneses are largely unknown. This study reveals a distinct mechanism by which EV71 induces apoptosis and autophagy in neural cells. Read More

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http://dx.doi.org/10.1080/21505594.2020.1766790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250321PMC
December 2020

Intracranial emergencies during pregnancy requiring urgent neurosurgical treatment.

Clin Neurol Neurosurg 2020 May 12;195:105905. Epub 2020 May 12.

Department of Neurosurgery, Hannover Medical School, Hannover, Germany.

Objective: Despite contemporary diagnostic and therapeutic techniques intracranial emergencies in the obstetric setting pose still a major challenge for the clinicians. There are limited guidelines and differing ethical views. Multidisciplinary teams are needed to support the pregnant woman in a way that she can deliver a viable and healthy child. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105905DOI Listing

Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database.

J Neurooncol 2020 May 19. Epub 2020 May 19.

Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden.

Objective: To investigate outcomes after surgery for rare brain tumors using the Swedish Brain Tumor Registry (SBTR).

Methods: This is a nationwide study of patient in the SBTR, validated in the Surveillance, Epidemiology, and End Results (SEER) registries. We included all adults diagnosed 2009-2015 with a rare brain tumor entity (n = 216), defined as ependymoma (EP, n = 64), subependymoma (SUBEP, n = 21), ganglioglioma (GGL, n = 54), pilocytic astrocytoma (PA, n = 56) and primitive neuroectodermal tumor (PNET, n = 21). Read More

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http://dx.doi.org/10.1007/s11060-020-03490-zDOI Listing

Heme is required for carbon monoxide activation of mitochondrial BK channel.

Eur J Pharmacol 2020 May 15;881:173191. Epub 2020 May 15.

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pastuera 3, 02-093, Warsaw, Poland. Electronic address:

Carbon monoxide (CO) is an endogenously synthesized gaseous mediator and is involved in the regulation of numerous physiological processes. Mitochondria, in which hemoproteins are abundant, are among the targets for CO action. Large-conductance calcium-activated (mitoBK) channels in the inner mitochondrial membrane share multiple biophysical similarities with the BK channels of the plasma membrane and could be a potential target for CO. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173191DOI Listing

Tc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans.

Contrast Media Mol Imaging 2020 27;2020:2525037. Epub 2020 Apr 27.

Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares (ININ), Ocoyoacac 52750, Estado de México, Mexico.

Overexpression of the chemokine-4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness. Recently, we reported the preclinical evaluation of Tc-CXCR4-L (cyclo-D-Tyr-D-[NMe]Orn[EDDA-Tc-6-hydrazinylnicotinyl]-Arg-NaI-Gly) as a SPECT radioligand capable of specifically detecting the CXCR4 protein. This research aimed to estimate the biokinetic behavior and radiation dosimetry of Tc-CXCR4-L in healthy subjects, as well as to correlate the radiotracer uptake by brain tumors in patients, with the histological grade of differentiation and CXCR4 expression evaluated by immunohistochemistry. Read More

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http://dx.doi.org/10.1155/2020/2525037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201577PMC

False Laboratory Test Result Through Colistin Interference in an Intensive Care Patient: Case Report.

Comb Chem High Throughput Screen 2020 May 13. Epub 2020 May 13.

Department of Medicinal Biochemistry, Harran University Faculty of Medicine, Sanliurfa. Turkey.

Background: In blood samples taken for testing purpose during drug infusion in the intensive care unit, there is a risk of interference due to drug-reactive interaction during the analysis.

Case Report: A 19-year-old female patient had undergone surgery for intracranial astrocytoma 12 years previously. Acinetobacter baumannii was found in the blood culture and deep tracheal aspiration fluid of the patient who had a fever (39. Read More

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http://dx.doi.org/10.2174/1386207323666200514072705DOI Listing

Frequent Clinical and Radiological Progression of Optic Pathway/Hypothalamic Pilocytic Astrocytoma in Adolescents and Young Adults.

Neurol Med Chir (Tokyo) 2020 May 14. Epub 2020 May 14.

Department of Neurosurgery, Tohoku University Graduate School of Medicine.

Most cases of optic hypothalamic pilocytic astrocytoma (OHPA) develop during childhood, so few cases of histologically verified OHPA have been described in adolescents and young adults (AYA). To elucidate the clinical features of OHPA with histological verification in AYA, we reviewed the clinical and radiological finding of OHPA treated at our institute from January 1997 and July 2017. AYA are aged between 15 and 39 years. Read More

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http://dx.doi.org/10.2176/nmc.oa.2019-0208DOI Listing

Paraneoplastic Raynaud's phenomenon associated to astrocytoma.

J Med Vasc 2020 May 27;45(3):161-164. Epub 2020 Mar 27.

Internal Medicine Unit, Department of Medico-Surgical Sciences and Biotechnologies, ICOT Hospital, "Sapienza" University of Rome, Via Franco-Faggiana, 1668, 04100 Latina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jdmv.2020.03.001DOI Listing

Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model.

Cancer Imaging 2020 May 12;20(1):35. Epub 2020 May 12.

Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Anti-angiogenic treatment of glioblastoma (GBM) complicates radiologic monitoring. We evaluated magnetic resonance elastography (MRE) as an imaging tool for monitoring the efficacy of anti-VEGF treatment of GBM.

Methods: Longitudinal studies were performed in an orthotopic GBM xenograft mouse model. Read More

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http://dx.doi.org/10.1186/s40644-020-00314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218549PMC

Expression of and Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme.

Biomolecules 2020 May 7;10(5). Epub 2020 May 7.

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.

The expression of desaturases is higher in many types of cancer, and despite their recognized role in oncogenesis, there has been no research on the expression of desaturases in glioblastoma multiforme (GBM). Tumor tissue samples were collected during surgery from 28 patients (16 men and 12 women) diagnosed with GBM. The effect of necrotic conditions and nutritional deficiency (mimicking conditions in the studied tumor zones) was studied in an in vitro culture of human brain (glioblastoma astrocytoma) U-87 MG cells. Read More

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http://dx.doi.org/10.3390/biom10050727DOI Listing

Advantages of gross total resection in patients with astrocytoma: A population-based study.

Oncol Lett 2020 Jun 6;19(6):3761-3774. Epub 2020 Apr 6.

Department of General Practice, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.

The present study aimed to investigate the association between surgical methods and survival outcomes in patients with astrocytoma. Patients diagnosed with astrocytoma between January 2004 and December 2015 were identified using the Surveillance, Epidemiology and End Results database. Kaplan-Meier curves and Cox regression were used to analyze the effects of surgical methods on overall survival (OS) and cancer-specific survival (CSS). Read More

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http://dx.doi.org/10.3892/ol.2020.11514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204487PMC

NF-кB inhibition by DHMEQ: in vitro antiproliferative effects on pilocytic astrocytoma and concise review of the current literature.

Childs Nerv Syst 2020 May 8. Epub 2020 May 8.

Departamento de Biologia, FFCLRP-USP, Av. Bandeirantes, 3900, Bairro Monte Alegre, Ribeirao Preto, SP, CEP 14040-901, Brazil.

Introduction: Pilocytic astrocytoma (PA) is the most common brain tumor that affects the pediatric population. Even though PA is benign and treatment only involves surgery, recurrent or unresectable tumors require chemo- and radiotherapy. Besides BRAF, CDKN2A, or IDH mutations, the hyperactivation of the nuclear factor NF-κB contributes to tumor growth and survival. Read More

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http://dx.doi.org/10.1007/s00381-020-04625-3DOI Listing

Comparative efficacy of antiangiogenic treatment for newly diagnosed glioblastoma: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2020 May;99(19):e20011

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing.

Background: Glioblastoma is the most common malignant primary brain tumor which has highly expressed vascular endothelial growth factor. To date, various antiangiogenic drugs have been investigated in clinical trials but with no overall conclusion, especially for newly diagnosed glioblastoma (nGBM). In this study, Bayesian network meta-analysis will be used to conduct a comprehensive analysis of the results of different clinical trials, and assess the efficacy of different antiangiogenic drugs on nGBM. Read More

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http://dx.doi.org/10.1097/MD.0000000000020011DOI Listing

Peripheral circulation miRNA expression of pediatric brain tumors and its relation to tumor miRNA expression levels.

J Neurosurg Pediatr 2020 May 8:1-9. Epub 2020 May 8.

2Department of Pediatrics, University of Connecticut Health Center, Farmington; and.

Objective: Micro RNAs (miRNAs) in peripheral biofluids (e.g., blood, saliva, urine) have been investigated as potential sources of diagnostic and prognostic information for a variety of tumor types, including pediatric brain tumors. Read More

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http://dx.doi.org/10.3171/2020.2.PEDS19715DOI Listing

The biological and clinical basis for early referral of low grade glioma patients to a surgical neuro-oncologist.

J Clin Neurosci 2020 May 4. Epub 2020 May 4.

Department of Neurosurgery, University of Calgary, Alberta, Canada.

The discovery of IDH1/2 (isocitrate dehydrogenase) mutation in large scale, genomewide mutational analyses of gliomas has led to profound developments in understanding tumourigenesis, and restructuring of the classification of both high and low grade gliomas. Owing to this progress made in the recognition of molecular markers which predict tumour behavior and treatment response, the increasing importance of adjuvant treatments such as chemo- and radiotherapy, and the tremendous advances in surgical technique and intraoperative monitoring which have facilitated superior extents of resection whilst preserving neurological functioning and quality of life, contemporary management of low grade glioma (LGG) has switched from a passive, observant approach to a more active, interventional one. Furthermore, this has implications for the manner in which patients with incidentally discovered and/or asymptomatic LGG are managed, and this review of the biological behaviour of LGG, as well as its clinical investigation and management, should act as a timely reminder to all clinicians of the importance of referring LGG patients early to a surgical neuro-oncologist who is not only familiar and acquainted with the vagaries of this disease process, but who, in addition, is devoted to delivering care to these patients with the support of a multi-disciplinary clinical decision-making unit, comprising medical neuro-oncologists, radiation oncologists and allied health professionals. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.119DOI Listing

Pathways of 4-Hydroxy-2-Nonenal Detoxification in a Human Astrocytoma Cell Line.

Antioxidants (Basel) 2020 May 5;9(5). Epub 2020 May 5.

Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno, 51, 56123 Pisa, Italy.

One of the consequences of the increased level of oxidative stress that often characterizes the cancer cell environment is the abnormal generation of lipid peroxidation products, above all 4-hydroxynonenal. The contribution of this aldehyde to the pathogenesis of several diseases is well known. In this study, we characterized the ADF astrocytoma cell line both in terms of its pattern of enzymatic activities devoted to 4-hydroxynonenal removal and its resistance to oxidative stress induced by exposure to hydrogen peroxide. Read More

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http://dx.doi.org/10.3390/antiox9050385DOI Listing

New deferiprone derivatives as multi-functional cholinesterase inhibitors: design, synthesis and in vitro evaluation.

Eur J Med Chem 2020 Apr 25;198:112350. Epub 2020 Apr 25.

Department of Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185, Rome, Italy. Electronic address:

In order to obtain multi-functional molecules for Alzheimer's disease, a series of deferiprone derivatives has been synthesized and evaluated in vitro with the hypothesis that they can restore the cholinergic tone and attenuate the dyshomeostasis of the metals mainly involved in the pathology. These compounds were designed as dual binding site AChE inhibitors: they possess an arylalkylamine moiety connected via an alkyl chain to a 3-hydroxy-4-pyridone fragment, to allow the simultaneous interaction with catalytic active site (CAS) and peripheral anionic site (PAS) of the enzyme. Deferiprone moiety and 2-aminopyridine, 2-aminopyrimidine or 2,4-diaminopyrimidine groups have been incorporated into these compounds, in order to obtain molecules potentially able to chelate bio-metals colocalized in Aβ plaques and involved in the generation of radical species. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112350DOI Listing

Pediatric Low-Grade Gliomas.

Cancers (Basel) 2020 May 4;12(5). Epub 2020 May 4.

Department of Pediatric Neurosurgery, University of Pittsburgh, Pittsburgh, PA 15224, USA.

Brain tumors constitute the largest source of oncologic mortality in children and low-grade gliomas are among most common pediatric central nervous system tumors. Pediatric low-grade gliomas differ from their counterparts in the adult population in their histopathology, genetics, and standard of care. Over the past decade, an increasingly detailed understanding of the molecular and genetic characteristics of pediatric brain tumors led to tailored therapy directed by integrated phenotypic and genotypic parameters and the availability of an increasing array of molecular-directed therapies. Read More

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http://dx.doi.org/10.3390/cancers12051152DOI Listing

PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review.

Int J Nanomedicine 2020 23;15:2789-2808. Epub 2020 Apr 23.

College of Medicine, Central Michigan University, Mt. Pleasant, MI 48859, USA.

Glioblastoma (GB) is a grade IV astrocytoma that maintains a poor prognosis with respect to current treatment options. Despite major advancements in the fields of surgery and chemoradiotherapy over the last few decades, the life expectancy for someone with glioblastoma remains virtually unchanged and warrants a new approach for treatment. Poly(amidoamine) (PAMAM) dendrimers are a type of nanomolecule that ranges in size (between 1 and 100 nm) and shape and can offer a new viable solution for the treatment of intracranial tumors, including glioblastoma. Read More

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http://dx.doi.org/10.2147/IJN.S243155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185330PMC

Analysis of P: A Novel Cytoplasmic Membrane-Associated Protein Encoded on Chromosome 19q13.3 in Glioma Specimens.

J Mol Neurosci 2020 May 4. Epub 2020 May 4.

Department of Neurosurgery (Divisions of Neuro-oncology) and MUSC Brain & Spine Tumor Program CSB 310, Medical University of South Carolina, Charleston, SC, 29425, USA.

Allelic losses of the q13.3 region of chromosome 19 have been documented in all major types of diffuse gliomas, strongly suggesting the presence of a 19q13.3 tumor suppressor gene responsible for these malignancies. Read More

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http://dx.doi.org/10.1007/s12031-020-01562-3DOI Listing

Glioblastoma Factors Increase the Migration of Human Brain Endothelial Cells by Increasing MMP-9/CXCR4 Levels.

Anticancer Res 2020 May;40(5):2725-2737

Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Niteroi, Brazil

Background/aim: Glioblastoma (GB) is the most aggressive type of tumor in the central nervous system and is characterized by resistance to therapy and abundant vasculature. Tumor vessels contribute to the growth of GB, and the tumor microenvironment is thought to influence tumor vessels. We evaluated the molecular communication between human GB cells and human brain microvascular endothelial cells (HBMEC) in vitro. Read More

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http://dx.doi.org/10.21873/anticanres.14244DOI Listing

Axl receptor tyrosine kinase is a regulator of apolipoprotein E.

Mol Brain 2020 May 4;13(1):66. Epub 2020 May 4.

Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada.

Alzheimer's disease (AD), the leading cause of dementia, is a chronic neurodegenerative disease. Apolipoprotein E (apoE), which carries lipids in the brain in the form of lipoproteins, plays an undisputed role in AD pathophysiology. A high-throughput phenotypic screen was conducted using a CCF-STTG1 human astrocytoma cell line to identify small molecules that could upregulate apoE secretion. Read More

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http://dx.doi.org/10.1186/s13041-020-00609-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197143PMC

A biphasic tumor in posterior cranial fossa and the pineal region in young adult.

Surg Neurol Int 2020 11;11:64. Epub 2020 Apr 11.

Departments of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia.

Background: Biphasic tumors of the central nervous system are rarely described and mainly consisted out of the glial and mesenchymal component. The tumor originated out of both astrocytes and pinealocytes, best to our knowledge, has not been described. We present a case of a brain tumor consisted out of pilocytic astrocytoma (PA) and pineocytoma as components situated in the pineal region and posterior cranial fossa in young adult. Read More

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http://dx.doi.org/10.25259/SNI_288_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193197PMC

The Diagnostic Value of Conventional MRI and CT Features in the Identification of the IDH1-Mutant and 1p/19q Co-Deletion in WHO Grade II Gliomas.

Acad Radiol 2020 Apr 28. Epub 2020 Apr 28.

Department of Neurosurgery, First Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address:

Rationale And Objectives: The classification of patients based on pathology and molecular features is important for improving WHO grade II glioma patient prognosis, especially for the initially diagnosed patients. Less invasive and more convenient methods for the prediction of the pathological type and gene status are desired.

Materials And Methods: This study investigates the ability to use conventional magnetic resonance imaging (MRI) and computed tomography (CT) features for determining the Isocitrate Dehydrogenase (IDH)-mutant and 1p/19q-codeletion status, through a retrospective review of information obtained from 189 WHO grade II glioma patients. Read More

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http://dx.doi.org/10.1016/j.acra.2020.03.008DOI Listing

Neuroimaging Findings in Children with Constitutional Mismatch Repair Deficiency Syndrome.

AJNR Am J Neuroradiol 2020 May 30;41(5):904-910. Epub 2020 Apr 30.

From the Department of Radiology (A.K., M.S., S.S., C.H.), Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Background And Purpose: Constitutional mismatch repair deficiency is a hereditary childhood cancer predisposition syndrome characterized by brain tumors and colorectal and hematologic malignancies. Our objective was to describe the neuroimaging findings in patients with constitutional mismatch repair deficiency.

Materials And Methods: This retrospective study included 14 children with genetically confirmed constitutional mismatch repair deficiency who were referred to 2 tertiary pediatric oncology centers. Read More

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http://dx.doi.org/10.3174/ajnr.A6512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228156PMC

Ribosomal Protein S27/Metallopanstimulin-1 (RPS27) in Glioma-A New Disease Biomarker?

Cancers (Basel) 2020 Apr 27;12(5). Epub 2020 Apr 27.

Tumorbiology Laboratory, Department of Neurosurgery, University of Würzburg, Josef-Schneider-Str. 11, D-97080 Würzburg, Germany.

Despite its significant overexpression in several malignant neoplasms, the expression of RPS27 in the central nervous system (CNS) is widely unknown. We identified the cell types expressing RPS27 in the CNS under normal and disease conditions. We acquired specimens of healthy brain (NB), adult pilocytic astrocytoma (PA) World Health Organization (WHO) grade I, anaplastic PA WHO grade III, gliomas WHO grade II/III with or without isocitrate dehydrogenase (IDH) mutation, and glioblastoma multiforme (GBM). Read More

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http://dx.doi.org/10.3390/cancers12051085DOI Listing

Cerebellar pleomorphic xanthoastrocytoma with BRAF V600E mutation: A case report.

World Neurosurg 2020 Apr 26. Epub 2020 Apr 26.

Department of Neurosurgery, Seoul National University Bundang Hospital; Seoul National University College of Medicine.

Background: Pleomorphic xanthoastrocytoma (PXA) is a rare type of astrocytoma with a peak incidence from 10 to 19 years of age. PXA is found most commonly in the supratentorium. When it is present in atypical areas like the infratentorium, it is often overlooked as a potential differential diagnosis. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.113DOI Listing

Recent Advances in Pathology: the 2020 Annual Review Issue of The Journal of Pathology.

J Pathol 2020 Apr;250(5):475-479

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

This year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and application of software in digital histopathology, implementation of biomarkers in pathology practice; genetics and epigenetics, and stromal influences in disease. The reviews are authored by experts in their field and provide comprehensive updates in the chosen areas, in which there has been considerable recent progress in our understanding of disease. Read More

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http://dx.doi.org/10.1002/path.5425DOI Listing

Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists.

J Med Chem 2020 May 27. Epub 2020 May 27.

PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.0c00435DOI Listing

Development of transient radioresistance during fractionated irradiation in vitro.

Radiother Oncol 2020 Apr 17;148:107-114. Epub 2020 Apr 17.

Amsterdam UMC location VUmc, Department of Radiation Oncology, Cancer Center Amsterdam, The Netherlands. Electronic address:

Background And Purpose: Effective combination treatments with fractionated radiotherapy rely on a proper understanding of the dynamic responses that occur during treatment. We explored the effect of clinical fractionated radiotherapy on the development and timing of radioresistance in tumor cells.

Methods And Materials: Different colon (HT29/HCT116/COLO320/SW480/RKO) and high-grade astrocytoma (D384/U-251MG) cancer cell lines were treated for 6 weeks with daily fractions of 2 Gy, 5 days per week. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.04.014DOI Listing