37,948 results match your criteria Astrocytoma


Aromatic monoterpenoid glycosides from rattan stems of Schisandra chinensis and their neuroprotective activities.

Fitoterapia 2019 Feb 19. Epub 2019 Feb 19.

Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. Electronic address:

Six new monoterpenoid glycosides, including thymoquinol 5-O-α-L-arabinopyranosyl-(1 → 6)-β-D-glucopyranoside (1), cuminic acid 7-O-α-D-arabinofuranosyl-(1 → 6)-β-d-glucopyranosyl ester (2), p-cymene 7-O-α-D-arabinofuranosyl-(1 → 6)-β-D-glucopyranoside (3), p-methylhyd- ratropic acid 9-O-α-D-arabinofuranosyl-(1 → 6)-β-d-glucopyranosyl ester (4), (R)-p-cymene 9-O-α- D-arabinofuranosyl-(1 → 6)-β-D-glucopyranoside (5), and (R)-p-cymene 9-O-β-D-apiofuranosyl-(1 → 6)-β-D-glucopyranoside (6), together with three known compounds, such as (R)-p-cymene 9-O-β-D-glucopyranoside (7), thymoquinol 5-O-β-D-glucopyranoside (8), and thymoquinol 2-O-β-D-glucopyranoside (9) were isolated from the 70%-EtOH extract of Schisandra chinensis rattan stems. The structures of the new compounds were elucidated by detailed spectroscopic analyses. Meanwhile, the neuroprotective activities of compounds 1-9 were evaluated on the two co-culture models of microglia and neurons cells and astrocytoma and neurons cells. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.012DOI Listing
February 2019

IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment.

J Histochem Cytochem 2019 Feb 22:22155419833334. Epub 2019 Feb 22.

UD of Biochemistry and Molecular Biology.

Glioblastoma (GB) is the most frequently occurring and aggressive primary brain tumor. Glioma stem cells (GSCs) and astrocytoma cells are the predominant malignant cells occurring in GB besides a highly heterogeneous population of migrating, neovascularizing and infiltrating myeloid cells that forms a complex tumor microenvironment (TME). Cross talk between the TME cells is pivotal in the biology of this tumor and, consequently, adaptor proteins at critical junctions of signaling pathways may be crucial. Read More

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http://dx.doi.org/10.1369/0022155419833334DOI Listing
February 2019

Guanosine Nucleolipids: Synthesis, Characterization, Aggregation and X-Ray Crystallographic Identification of Electricity-Conducting G-ribbons.

Chem Biodivers 2019 Feb 22. Epub 2019 Feb 22.

) Anatomy and Cell Biology, Department of Medical Cell Biology, Philipps-University of Marburg, Robert-Koch-Str. 8, DE Marburg, GERMANY.

The lipophilization of β-D-riboguanosine (1) with various symmetric as well as asymmetric ketones is described (→ 3a-f). The formation of the corresponding O-2', 3'-ketals is accompanied by the appearance of various fluorescent by-products which were isolated chromatographically as mixtures and tentatively analyzed by ESI mass spectrometry. The mainly formed guanosine nucleolipids were isolated and characterized by elemental analyses, 1H-, 13C-NMR and UV spectroscopy. Read More

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http://dx.doi.org/10.1002/cbdv.201900024DOI Listing
February 2019

Correlation of Ki-67 Index with Volumetric Segmentation and its Value as a Prognostic Marker in Glioblastoma.

World Neurosurg 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurosurgery, University Medicine of Rostock, Rostock, Germany.

Objective: Previous research has shown a strong correlation between the Ki-67 proliferation index and grade of malignancy in astrocytoma. Ki-67 has also shown encouraging results as a prognostic marker for patients´ overall survival (OS). We focus on whether the index is linked to the appearance of glioblastoma on pre-treatment MRI or to OS. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.006DOI Listing
February 2019

Carbon ion radiotherapy boost in the treatment of glioblastoma: a randomized phase I/III clinical trial.

Cancer Commun (Lond) 2019 Feb 20;39(1). Epub 2019 Feb 20.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Pudong, 4365 Kangxin Road, Shanghai, 201321, P. R. China.

Background: Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival < 15 months. Clearly, an improvement in treatment outcomes is needed. However, the emergence of these malignancies within the delicate brain parenchyma and their infiltrative growth pattern severely limit the use of aggressive local therapies. Read More

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http://dx.doi.org/10.1186/s40880-019-0351-2DOI Listing
February 2019

Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease.

BMC Neurosci 2019 Feb 20;20(1). Epub 2019 Feb 20.

Department of Bio-Medical Sciences, Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA, 19131, USA.

Background: Epidemiologic studies strongly suggest that the pathophysiology of late-onset Alzheimer disease (AD) versus early-onset AD has environmental rather than genetic causes, thus revealing potentially novel therapeutic targets to limit disease progression. Several studies supporting the "pathogen hypothesis" of AD demonstrate a strong association between pathogens and the production of β-amyloid, the pathologic hallmark of AD. Although the mechanism of pathogen-induced neurodegeneration of AD remains unclear, astrocytes, a key player of the CNS innate immune response and producer/metabolizer of β-amyloid, have been implicated. Read More

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http://dx.doi.org/10.1186/s12868-019-0489-5DOI Listing
February 2019

Clinico-Histomorphological and Immunohistochemical Profile of Anaplastic Pleomorphic Xanthoastrocytoma: Report of Five Cases and Review of Literature.

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):265-272

Department of Neurosurgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Pleomorphic xanthoastrocytoma is a rare tumour of children and young adults, particularly for those with features of anaplasia. This retrospective study comprises five cases of anaplastic pleomorphic xanthoastrocytomas diagnosed over a period of 4 years in a tertiary care institute. A detailed clinicopathological and immunohistochemical profile of the tumours were noted from the hospital database. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375371PMC
October 2018

Pontine tumor in a neonate: case report and analysis of the current literature.

J Neurosurg Pediatr 2019 Feb 15:1-7. Epub 2019 Feb 15.

1Pediatric Hematology and Oncology, Goethe University; Departments of.

Tumors of the central nervous system represent the largest group of solid tumors found in pediatric patients. Pilocytic astrocytoma is the most common pediatric glioma, mostly located in the posterior fossa. The majority of brainstem tumors, however, are classified as highly aggressive diffuse intrinsic pontine gliomas (DIPGs) and their prognosis is dismal. Read More

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http://dx.doi.org/10.3171/2018.10.PEDS18215DOI Listing
February 2019

The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma.

Childs Nerv Syst 2019 Feb 15. Epub 2019 Feb 15.

Department of Paediatric Oncology, Alder Hey Children's Hospital, Eaton Road, Liverpool, L12 2AP, UK.

Objectives: Paediatric cerebellar pilocytic astrocytomas (PA) (WHO grade 1) are amongst the most common of childhood brain tumours and are generally amenable to resection, with surgery alone being curative in the majority of cases. There is, however, a lack of consensus regarding the frequency and duration of post-treatment MRI surveillance for these tumours. This is important, as follow-up imaging is a significant use of resources and often associated with patient and family anxiety. Read More

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http://link.springer.com/10.1007/s00381-019-04078-3
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http://dx.doi.org/10.1007/s00381-019-04078-3DOI Listing
February 2019
3 Reads

Concurrent Versus Sequential Chemoradiation for Low-grade Gliomas Meeting RTOG 9802 Criteria.

Am J Clin Oncol 2019 Feb 12. Epub 2019 Feb 12.

Departments of Radiation Oncology.

Purpose: Radiation Therapy Oncology Group (RTOG) 9802 has established postoperative radiation therapy (RT) and chemotherapy sequentially as the new standard of care for patients with high-risk low-grade glioma (LGG) meeting trial criteria. Although this trial investigated sequential chemoradiation therapy (sCRT) with RT followed by chemotherapy, it is unknown whether concurrent chemoradiation therapy (cCRT) may offer advantages over sCRT.

Materials And Methods: The National Cancer Database (NCDB) was queried for newly diagnosed World Health Organization (WHO) grade II glioma. Read More

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http://dx.doi.org/10.1097/COC.0000000000000519DOI Listing
February 2019
1 Read

Atypical anaplastic astrocytoma with unique molecular features and diffuse leptomeningeal spread in a child with long-term survival.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA.

Paediatric high-grade gliomas, including glioblastoma and anaplastic astrocytoma, make up 8%-12% of paediatric central nervous system tumours and have poor prognosis, with 2-year survival less than 30% and overall survival less than 10%. The only known prognostic factors in this population include extent of resection and tumour histological grade. We present the case of a 9-year-old boy with disseminated anaplastic astrocytoma treated with subtotal resection, craniospinal radiation and temozolomide, with 8-year survival despite metastatic disease at presentation and subtotal resection. Read More

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http://dx.doi.org/10.1136/bcr-2018-228153DOI Listing
February 2019
1 Read

[Ocular Phenotype and Complications in Patients with Tuberous Sclerosis Complex (TSC)].

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Augenklinik, UniversitätsSpital Zürich, Schweiz.

Background: Evaluation and comparison of the ocular phenotype in patients diagnosed with tuberous sclerosis complex (TSC). Analysis of ocular complications during follow-up.

Patients And Methods: A retrospective chart review was performed of patients with TSC who had received an ocular examination at the eye clinic of the University Hospital Zurich. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0804-1816
Publisher Site
http://dx.doi.org/10.1055/a-0804-1816DOI Listing
February 2019
3 Reads

Efficacy and safety of mTOR inhibitors (rapamycin and its analogues) for tuberous sclerosis complex: a meta-analysis.

Orphanet J Rare Dis 2019 Feb 13;14(1):39. Epub 2019 Feb 13.

Department of Pharmacy, Peking University First Hospital, 6 Dahongluochang Street, Xicheng District, Beijing, 100034, China.

Background: The treatment of tuberous sclerosis complex (TSC) using mammalian target of rapamycin (mTOR) inhibitors is clinically promising. The aim of the present study was to evaluate the efficacy and safety of mTOR inhibitors for improving the clinical symptoms of TSC.

Methods: We performed a systematic search of major electronic databases (PubMed, EMBASE, Cochrane Library and WanFang, CNKI, and VIP databases) to identify randomized controlled trials (RCTs) and quasi-randomized studies from the date of database inception to November 2017; the Chinese Food and Drug Administration and clinicaltrials. Read More

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http://dx.doi.org/10.1186/s13023-019-1012-xDOI Listing
February 2019
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Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA.

Acta Neuropathol 2019 Feb 13. Epub 2019 Feb 13.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Papillary glioneuronal tumor (PGNT) is a WHO-defined brain tumor entity that poses a major diagnostic challenge. Recently, SLC44A1-PRKCA fusions have been described in PGNT. We subjected 28 brain tumors from different institutions histologically diagnosed as PGNT to molecular and morphological analysis. Read More

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http://dx.doi.org/10.1007/s00401-019-01969-2DOI Listing
February 2019
2 Reads

Atypical Presentation of Glioblastoma Multiforme.

Eur J Case Rep Intern Med 2018 27;5(9):000954. Epub 2018 Sep 27.

Neurology Department, Henry Ford Health System, Detroit, MI, USA.

Background: Glioblastoma multiforme (GBM) is a highly malignant glial tumour classified by the World Health Organization (WHO) as a stage IV astrocytoma. It varies in shape and size and can be cystic, vascular and necrotic. It often appears as a ring-enhancing lesion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.12890/2018_000954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346815PMC
September 2018
1 Read

A semi-automated whole exome sequencing workflow leads to increased diagnostic yield and identification of novel candidate variants.

Cold Spring Harb Mol Case Stud 2019 Feb 12. Epub 2019 Feb 12.

Children's Hospital Los Angeles;

Background: Advancing the clinical utility of whole exome sequencing (WES) for patients with suspected genetic disorders is largely driven by bioinformatics approaches that streamline data processing and analysis.

Methods: Herein, we describe our experience with implementing a semi-automated and phenotype-driven WES diagnostic workflow, incorporating both the DRAGEN pipeline and the Exomiser variant prioritization tool, at an academic children's hospital with an ethnically diverse pediatric patient population.

Results: We achieved a 41% molecular diagnostic rate for 66 duo-, quad- or trio- WES cases, and 28% for 40 singleton-WES cases. Read More

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http://dx.doi.org/10.1101/mcs.a003756DOI Listing
February 2019
1 Read

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients.

Neuro Oncol 2019 Feb 12. Epub 2019 Feb 12.

Department of Oncology, Clinical Research Unit, Dr Dubois Ferrière Dinu Lipatti Research Foundation, Geneva University Hospital, Geneva, Switzerland.

Background: Peptide vaccines offer the opportunity to elicit glioma-specific T cells with tumor killing ability. Using antigens eluted from the surface of glioblastoma samples, we designed a phase I/II study to test safety and immunogenicity of the IMA950 multipeptide vaccine adjuvanted with poly-ICLC in HLA-A2 + glioma patients.

Methods: Adult patients with newly diagnosed glioblastoma (n=16) and grade III astrocytoma (n=3) were treated with radiochemotherapy followed by IMA950/poly-ICLC vaccination. Read More

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http://dx.doi.org/10.1093/neuonc/noz040DOI Listing
February 2019
2 Reads
5.562 Impact Factor

Incidence of childhood CNS tumours in Britain and variation in rates by definition of malignant behaviour: population-based study.

BMC Cancer 2019 Feb 11;19(1):139. Epub 2019 Feb 11.

Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds, UK.

Background: Intracranial and intraspinal tumours are the most numerous solid tumours in children. Some recently defined subtypes are relatively frequent in childhood. Many cancer registries routinely ascertain CNS tumours of all behaviours, while others only cover malignant neoplasms. Read More

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http://dx.doi.org/10.1186/s12885-019-5344-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371471PMC
February 2019
1 Read

Mechanisms of Toxicity of Industrially Relevant Silicomanganese Dust on Human 1321N1 Astrocytoma Cells: An In Vitro Study.

Int J Mol Sci 2019 Feb 10;20(3). Epub 2019 Feb 10.

Department of Biological and Chemical Work Environment, National Institute of Occupational Health, Pb 8149 Dep., N-0033 Oslo, Norway.

Tremendous efforts are applied in the ferroalloy industry to control and reduce exposure to dust generated during the production process, as inhalable Mn-containing particulate matter has been linked to neurodegenerative diseases. This study aimed to investigate the toxicity and biological effects of dust particles from laboratory-scale processes where molten silicomanganese (SiMn) was exposed to air, using a human astrocytoma cell line, 1321N1, as model system. Characterization of the dust indicated presence of both nano-sized and larger particles averaging between 100 and 300 nm. Read More

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http://dx.doi.org/10.3390/ijms20030740DOI Listing
February 2019

Neurosurgical treatment of pediatric pleomorphic xanthoastrocytomas: long-term follow-up of a single-institution, consecutive series of 12 patients.

J Neurosurg Pediatr 2019 Feb 8:1-5. Epub 2019 Feb 8.

5Radiology, Oslo University Hospital; and.

OBJECTIVEThe authors conducted a study to delineate the long-term results of the surgical treatment of pediatric pleomorphic xanthoastrocytomas (PXAs).METHODSAll consecutive children and adolescents (0-20 years) who underwent primary tumor resection for a PXA during the years 1972-2015 were included in this retrospective study on surgical morbidity, mortality rate, academic achievement, and/or work participation. Gross motor function and activities of daily living were scored according to the Barthel Index. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18449DOI Listing
February 2019
6 Reads

Language Mapping of Hindi and English in A Bilingual Patient During Resection of A Right Frontal Glioma - A Case Report.

World Neurosurg 2019 Feb 5. Epub 2019 Feb 5.

Division of Neurosurgery, University Surgical Cluster, National University Health System (NUHS), 1E, Kent Ridge Road, Singapore 119228.

Background: Recent advancements in understanding the molecular basis of gliomas as well as new concepts of neuronal plasticity have shown importance of maximal resection in gliomas to improve progression free overall survival. Awake craniotomies with intra-operative cortical and subcortical mapping has helped to achieve this aim while allowing us to preserve executive function including language. Language mapping becomes a daunting task in individuals who are bilingual due to complexity of varied cortical representation of different languages. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.153DOI Listing
February 2019
1 Read
2.417 Impact Factor

Freiburg Neuropathology Case Conference : Posterior Fossa Mass in an Infant.

Clin Neuroradiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Neuropathology, Medical Centre-University of Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00062-019-00759-3DOI Listing
February 2019
1 Read

Outcome of Bevacizumab Therapy in Patients with Recurrent Glioblastoma Treated with Angiotensin System Inhibitors.

Cancer Invest 2018 ;36(9-10):512-519

a Department of Radiation Biology, Department of Oncology , The Finsen Center , Rigshospitalet, Copenhagen , Denmark.

Purpose: Antihypertensive therapy may improve bevacizumab efficacy in cancer patients. We examined efficacy and toxicity of angiotensin system inhibitors (ASI) and other antihypertensive drugs in bevacizumab treated recurrent glioblastoma patients.

Methods: We retrospectively combined a national prescription registry with a clinical database with recurrent glioblastoma patients (n = 243). Read More

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http://dx.doi.org/10.1080/07357907.2018.1544639DOI Listing
February 2019
1 Read

Pediatric malignancies in neurofibromatosis type 1: A population-based cohort study.

Int J Cancer 2019 Feb 6. Epub 2019 Feb 6.

Institute of Biomedicine, University of Turku, Turku, Finland.

Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome with an incidence of 1:2,000. Patients with NF1 have an increased cancer risk and mortality, but there are no population-based cohort studies specifically investigating the risk of childhood malignancies. We used the Finnish NF1 cohort to analyze the incidence, risk and prognosis of malignancies in NF1 patients <20 years of age. Read More

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http://dx.doi.org/10.1002/ijc.32187DOI Listing
February 2019
2 Reads

Malignant Glioma in the Cerebellum Presenting as Multiple Small Lesions.

Case Rep Oncol Med 2019 6;2019:6725127. Epub 2019 Jan 6.

Department of Neurosurgery, Kariya Toyota General Hospital, 5-15 Sumiyoshi-cho, Kariya, Aichi, 448-8505, Japan.

Malignant glioma, the most common malignant primary brain tumor in adults, usually occurs in supratentorial space as a single mass lesion, and cerebellar location and multiple appearance are uncommon. We report a case of a 69-year-old female with three lesions simultaneously found in the cerebellum on magnetic resonance images (MRIs) after suffering from gait disturbance. Two lesions were around 15 mm in size and the other one was observed as a spotty enhancement. Read More

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http://dx.doi.org/10.1155/2019/6725127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339752PMC
January 2019
1 Read

Hemorrhagic presentation of frontal partially calcified pilocytic astrocytoma in an 18-year-old woman: A case report and literature review as "clinical case".

Neurochirurgie 2019 Feb 30;65(1):32-35. Epub 2019 Jan 30.

Department of radiology, Assistance publique-Hôpitaux de Paris, Bichat Hospital, 46, rue Henri-Huchard, 75018, Paris, France; INSERM U1148, 75018 Paris, France; University Paris 7, Faculté de Médecine Xavier-Bichat, 75018 Paris, France. Electronic address:

We report an unusual case of a frontal partially calcified pilocytic astrocytoma (PA) (WHO grade 1) in an 18-year-old woman who presented with acute, spontaneous intracerebral hemorrhage. Histopathology revealed the PA was mixed with psammoma bodies and areas of vascular proliferation responsible for a hypervascular pattern. The patient underwent a total gross resection. Read More

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http://dx.doi.org/10.1016/j.neuchi.2018.12.002DOI Listing
February 2019

Targeted next-generation sequencing panel (TruSight Tumor 170) in diffuse glioma: a single institutional experience of 135 cases.

J Neurooncol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea.

Purpose: The TruSight Tumor 170 (TST-170) panel consists of a DNA workflow for the identification of single-nucleotide variants, small insertions and deletions, and copy number variation, as well as a panel of 55 genes for a RNA workflow for the identification of splice variants and gene fusions. To date, the application of TST-170 in diffuse gliomas (DGs) has not been described.

Methods: We analyzed 135 samples of DG, which were diagnosed by WHO criteria based on histological features and conventional molecular tests including immunostaining, 1p/19q FISH, and analysis of MGMT methylation and TERT promoter mutation. Read More

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http://dx.doi.org/10.1007/s11060-019-03114-1DOI Listing
February 2019
5 Reads

Occurrence of high-grade glioma in Noonan syndrome: Report of two cases.

Pediatr Blood Cancer 2019 Jan 28:e27625. Epub 2019 Jan 28.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Hospital of Geneva, Geneva, Switzerland.

Noonan syndrome (NS) is an autosomal dominant disorder commonly caused by PTPN11 germline mutations. Patients are characterized by short stature, congenital heart defects, facial dysmorphism, and increased risk of malignancies including brain tumors. Commonly associated brain tumors are dysembryoplastic neuroepithelial tumor and low-grade glioma. Read More

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http://dx.doi.org/10.1002/pbc.27625DOI Listing
January 2019
1 Read

Influence of pregnancy on glioma patients.

Acta Neurochir (Wien) 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurosurgery, Goethe University Hospital, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

Background: Data about the influence of pregnancy on progression-free survival and overall survival of glioma patients are sparse and controversial. We aimed at providing further evidence on this relation.

Methods: The course of 18 glioma patients giving birth to 23 children after tumor surgery was reviewed and compared to the course of 18 nulliparous female patients matched for tumor diagnosis including molecular markers, extent of resection, and tumor location. Read More

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http://dx.doi.org/10.1007/s00701-019-03823-6DOI Listing
January 2019
1 Read
1.788 Impact Factor

CAR-T cells : indications actuelles en pédiatrie et perspectives de développement.

Bull Cancer 2018 Dec;105 Suppl 2:S147-S157

Service d'Hématologie Pédiatrique, Hôpital Universitaire Robert Debré (APHP), 75019 Paris, France; Université Paris Diderot, 75010 Paris, France; EA 3518 Institut Universitaire d'Hématologie, 75010 Paris, France. Electronic address:

Car T Cells: CURRENT INDICATIONS IN CHILDREN AND PERSPECTIVES: Acute lymphoblastic leukemia (ALL) is the first cause of cancer in children. Five-year overall survival is greater than 90% but leukemia remains a major cause of death from cancer in children. A new class of immunotherapy based on a chimeric antigen receptor "CAR" targeting the CD19 on the B leukemic cells and that is transduced in an autologous or allogenic T lymphocyte will allow to transform the prognosis of refractory or relapsed B-ALL. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00074551193004
Publisher Site
http://dx.doi.org/10.1016/S0007-4551(19)30045-1DOI Listing
December 2018
2 Reads

Outcomes Following Proton Therapy for Pediatric Low-Grade Glioma.

Int J Radiat Oncol Biol Phys 2019 Jan 23. Epub 2019 Jan 23.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL.

Background/objectives: Dosimetric studies show that proton therapy can reduce the low/intermediate radiation dose to uninvolved tissue in children with low-grade glioma (LGG). For this reason, LGG is the 4th most common pediatric tumor treated with proton therapy, yet clinical outcome data on efficacy and toxicity are limited.

Design/methods: We reviewed the medical records of 174 children (≤21 years old) with non-metastatic LGG enrolled on a prospective protocol and treated with proton therapy between 2007 and 2017 to assess clinical outcomes and toxicity, and analyze patient, tumor, and treatment-related variables. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.01.078DOI Listing
January 2019
16 Reads

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure.

Purinergic Signal 2019 Jan 25. Epub 2019 Jan 25.

Department of Protein Structure, Function and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8582, Japan.

P2X purinergic receptors are ATP-driven ionic channels expressed as trimers and showing various functions. A subtype, the P2X4 receptor present on microglial cells is highly involved in neuropathic pain. In this study, in order to prepare antibodies recognizing the native structure of rat P2X4 (rP2X4) receptor, we immunized mice with rP2X4's head domain (rHD, Gln111-Val167), which possesses an intact structure stabilized by S-S bond formation (Igawa and Abe et al. Read More

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http://dx.doi.org/10.1007/s11302-019-09646-5DOI Listing
January 2019
1 Read

FGL2 promotes tumor progression in the CNS by suppressing CD103 dendritic cell differentiation.

Nat Commun 2019 01 25;10(1):448. Epub 2019 Jan 25.

Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and primary glioblastoma (GBM) cells. FGL2 knockout in tumor cells did not affect tumor-cell proliferation in vitro or tumor progression in immunodeficient mice but completely impaired GBM progression in immune-competent mice. Read More

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http://dx.doi.org/10.1038/s41467-018-08271-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347641PMC
January 2019
3 Reads
10.742 Impact Factor

The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma.

Nat Commun 2019 01 25;10(1):442. Epub 2019 Jan 25.

Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, 02115, USA.

MicroRNA deregulation is a consistent feature of glioblastoma, yet the biological effect of each single gene is generally modest, and therapeutically negligible. Here we describe a module of microRNAs, constituted by miR-124, miR-128 and miR-137, which are co-expressed during neuronal differentiation and simultaneously lost in gliomagenesis. Each one of these miRs targets several transcriptional regulators, including the oncogenic chromatin repressors EZH2, BMI1 and LSD1, which are functionally interdependent and involved in glioblastoma recurrence after therapeutic chemoradiation. Read More

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http://dx.doi.org/10.1038/s41467-019-08390-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347618PMC
January 2019
2 Reads

Surgical Management and Outcome of a Bilateral Thalamic Pilocytic Astrocytoma: Case Report and Review of the Literature.

Pediatr Neurosurg 2019 Jan 24:1-4. Epub 2019 Jan 24.

Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.

The incidence of bilateral thalamic glioma in children is not reported in the literature. The majority of cases comprise either diffuse astrocytoma, anaplastic astrocytoma, or glioblastoma. Partial surgical resection or biopsy followed by adjuvant therapy is the usual treatment for bilateral thalamic gliomas. Read More

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http://dx.doi.org/10.1159/000495990DOI Listing
January 2019
5 Reads

Influence of molecular classification in anaplastic glioma for determining outcome and future approach to management.

J Med Imaging Radiat Oncol 2019 Jan 24. Epub 2019 Jan 24.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Introduction: Assess survival of patients with anaplastic glioma (AG) and the relationship to molecular subtype.

Methods: Patients with AG managed with IMRT between 2008 and 2014 were entered into a prospective database assessing relapse-free survival (RFS) and overall survival (OS). Isocitrate dehydrogenase (IDH) mutations were assessed prospectively from 2011, and subsequent testing of historical patients allowing categorisation under WHO 2016 classification as anaplastic astrocytoma IDH wild type (AAwt), anaplastic astrocytoma IDH mutated (AAmut), anaplastic oligodendroglioma (AOD) or other glial tumour (OTH). Read More

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http://dx.doi.org/10.1111/1754-9485.12850DOI Listing
January 2019
3 Reads

Early clinical trials of Toca 511 and Toca FC show a promising novel treatment for recurrent malignant glioma.

Expert Opin Investig Drugs 2019 Mar;28(3):207-216

a Department of Neurosurgery , Emory University School of Medicine , Atlanta , GA , USA.

Introduction: Glioblastoma and anaplastic astrocytoma are two of the most aggressive and common glioma malignancies in adults. These high-grade gliomas (HGG) universally recur despite aggressive treatment modalities and have a median overall survival (mOS) of approximately 14 months from initial diagnosis. Upon recurrence, there is no standard of care and these patients have a dismal prognosis of around 9 months at time of recurrence. Read More

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http://dx.doi.org/10.1080/13543784.2019.1572112DOI Listing
March 2019
1 Read

Association between medical academic genealogy and publication outcome: impact of unconscious bias on scientific objectivity.

Acta Neurochir (Wien) 2019 Feb 23;161(2):205-211. Epub 2019 Jan 23.

Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.

Background: Our previous studies suggest that the training history of an investigator, termed "medical academic genealogy", influences the outcomes of that investigator's research. Here, we use meta-analysis and quantitative statistical modeling to determine whether such effects contribute to systematic bias in published conclusions.

Methods: A total of 108 articles were identified through a comprehensive search of the high-grade glioma (HGG) surgical resection literature. Read More

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http://dx.doi.org/10.1007/s00701-019-03804-9DOI Listing
February 2019
2 Reads

Importance of GFAP isoform-specific analyses in astrocytoma.

Glia 2019 Jan 22. Epub 2019 Jan 22.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Gliomas are a heterogenous group of malignant primary brain tumors that arise from glia cells or their progenitors and rely on accurate diagnosis for prognosis and treatment strategies. Although recent developments in the molecular biology of glioma have improved diagnosis, classical histological methods and biomarkers are still being used. The glial fibrillary acidic protein (GFAP) is a classical marker of astrocytoma, both in clinical and experimental settings. Read More

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http://dx.doi.org/10.1002/glia.23594DOI Listing
January 2019
1 Read

Oligo-astrocytoma in LZTR1-related Noonan syndrome.

Eur J Med Genet 2019 Jan 19. Epub 2019 Jan 19.

Department of Genetics, APHP-Robert DEBRE University Hospital, Denis Diderot School of Medicine, Paris University, France; INSERM UMR1141, Paris, France. Electronic address:

Mutations in LZTR1, already known to be causal in familial schwannomatosis type 2, have been recently involved in a small proportion of patients with autosomal dominant and autosomal recessive Noonan syndrome. LZTR1 is also a driver gene in non syndromal glioblastoma. We report a 26-year-old patient with typical Noonan syndrome, and the dominantly transmitted c. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.01.007DOI Listing
January 2019
3 Reads

Pattern of intracranial tumours in a tertiary hospital in Ghana.

Ghana Med J 2018 Jun;52(2):79-83

Neurosurgery Unit, Department of Surgery, Korle Bu Teaching Hospital, P.M.B KB77, Accra. Ghana.

Objective: This study seeks to describe the pattern of intracranial tumours in Korle Bu Teaching Hospital (KBTH) based on patient demographics, clinical presentation, spatial distribution of tumour and histological findings.

Method: The study design is retrospective and descriptive. Data was obtained from the clinical records of patients with intracranial tumours treated in our neurosurgery unit between January 2010 to December 2015, and histology reports obtained from the histopathology unit. Read More

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http://dx.doi.org/10.4314/gmj.v52i2.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326539PMC
June 2018
3 Reads

Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
6 Reads

Mitochondrial potassium channels - an overview.

Postepy Biochem 2018 10;64(3):196-212

Instytut Biologii Doświadczalnej PAN im. M. Nenckiego w Warszawie.

Mitochondria play a fundamental role in ATP synthesis within the majority of mammalian cells. Potassium channels present in the inner mitochondrial membrane are fine regulators of mitochondrial function, based on inner membrane K+ permeability. These channels are regulated by a plethora of factors and conditions in a way similar to plasma membrane potassium channels. Read More

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http://dx.doi.org/10.18388/pb.2018_132DOI Listing
October 2018
1 Read

Extent of resection predicts risk of progression in adult pilocytic astrocytoma.

Br J Neurosurg 2019 Jan 17:1-5. Epub 2019 Jan 17.

a Department of Neurosurgery , The Walton Centre NHS Foundation Trust , Lower Lane , Liverpool , UK.

Object: Pilocytic astrocytomas are rare tumours in adults. Presentation, management and prognostic factors are poorly characterised.

Methods: Retrospective single centre study from 2000 to 2016. Read More

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https://www.tandfonline.com/doi/full/10.1080/02688697.2018.1
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http://dx.doi.org/10.1080/02688697.2018.1549315DOI Listing
January 2019
10 Reads

MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging - design, implementation and application on the example of DCE-MRI.

BMC Bioinformatics 2019 Jan 16;20(1):31. Epub 2019 Jan 16.

Division of Medical Image Computing, German Cancer Research Center DKFZ, Heidelberg, Germany.

Background: Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)/computed tomography (CT), apparent diffusion coefficient calculations and intravoxel incoherent motion modeling in diffusion-weighted MRI and Z-spectra analysis in chemical exchange saturation transfer MRI. Most available software tools are limited to a special purpose and do not allow for own developments and extensions. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2588-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335810PMC
January 2019
7 Reads

Immunohistochemical Evaluation of Hemostatic Changes in Glioblastoma Multiforme and Low-Grade Astrocytoma.

Turk Neurosurg 2018 Oct 17. Epub 2018 Oct 17.

Heinrich-Braun-Clinic.

Aim: In glioblastoma multiforme, the balance between the procoagulant system, anticoagulant system and fibrinolytic system is impaired in favour of hypercoagulability. The aim of this study was to compare glioblastoma multiforme with astrocytoma grade II by subjectively evaluating the levels of prothrombin and biotinylation thrombin, and G protein serum protease activatin receptors, as tissue factors causing hypercoagulation and affecting coagulation.

Material And Methods: Specimens from 35 cases with glioblastoma multiforme and 23 cases with astrocytoma grade II were evaluated immunohistochemically. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.22739-18.3DOI Listing
October 2018
1 Read

Successful Use of Fludrocortisone in a Child with Refractory Cerebral Salt Wasting Syndrome: A Case Report and Review of Literature.

Cureus 2018 Oct 27;10(10):e3505. Epub 2018 Oct 27.

Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, USA.

Hyponatremia post-neurosurgical intervention can be dangerous and potentially life-threatening. Two of its most common causes are cerebral salt wasting (CSW) and syndrome of inappropriate anti-diuretic hormone release (SIADH). CSW is proposed to be secondary not only to the elevated levels of circulating atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) but inhibition of steroidogenesis in the zona glomerulosa of the adrenal cortex, thus resulting in mineralocorticoid deficiency. Read More

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https://www.cureus.com/articles/15447-successful-use-of-flud
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http://dx.doi.org/10.7759/cureus.3505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318137PMC
October 2018
4 Reads

Anti-C1-inactivator treatment of glioblastoma.

Oncotarget 2018 Dec 21;9(100):37421-37428. Epub 2018 Dec 21.

The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden.

Purpose: Glioblastoma multiforme (GBM) or astrocytoma grade IV is the most common type of primary brain tumor in adults. In the present study, we investigate the role of the complement system in the glioblastoma situation in an experimental model, since we have previously been able to show a blockade of this system in the glioblastoma setting.

Technique And Results: A GFP-positive glioblastoma cell line was used to induce glioblastomas subcutaneously in rats (n=42). Read More

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http://dx.doi.org/10.18632/oncotarget.26456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324776PMC
December 2018

Astrocytoma progression scoring system based on the WHO 2016 criteria.

Sci Rep 2019 Jan 14;9(1):96. Epub 2019 Jan 14.

Department of Neurosurgery, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, Liaoning Province, 110001, PR China.

Diffuse astrocytoma (including glioblastoma) is morbid with a worse prognosis than other types of glioma. Therefore, we sought to build a progression-associated score to improve malignancy and prognostic predictions for astrocytoma. The astrocytoma progression (AP) score was constructed through bioinformatics analyses of the training cohort (TCGA RNA-seq) and included 18 genes representing distinct aspects of regulation during astrocytoma progression. Read More

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http://www.nature.com/articles/s41598-018-36471-4
Publisher Site
http://dx.doi.org/10.1038/s41598-018-36471-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331604PMC
January 2019
4 Reads