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Pulm Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Canada.

In the general population, particularly in individuals with asthma, cough is a common symptom, often reported after exertion, although regular exercise may be associated with a reduction in the prevalence of cough. In athletes, exercise-induced cough is also a particularly frequent symptom. The main etiologies of cough in athletes are somewhat similar to non-athletes, including asthma/airway hyperresponsiveness, upper airways disorders such as allergic or non-allergic rhinitis, and exercise-induced laryngeal obstruction, although these conditions are more frequently observed in athletes. Read More

BMJ Open Sport Exerc Med 2019 23;5(1):e000487. Epub 2019 Jan 23.

Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.

Objective: A constricted, upper chest breathing pattern and postural dealignments habitually accompany exercise-induced laryngeal obstruction (EILO), but there are few effective treatments for athletes presenting with EILO. This case series was conducted to examine whether physiotherapy based on principles from the Norwegian psychomotor physiotherapy (NPMP) combined with elements of cognitive behavioural therapy can reduce laryngeal distress in athletes with EILO.

Methods: Respiratory distress in four subjects was examined by interview prior to a physiotherapeutic body examination. Read More

Respir Care 2019 Feb 5. Epub 2019 Feb 5.

Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho, São Paulo, Brazil.

Background: Single-step tests have been proposed as simple and inexpensive challenges to diagnose exercise-induced bronchoconstriction (EIB) in the pediatric population. Work performed and the resulting ventilation, however, might be substantially lower in stepping than running. This might decrease the diagnostic yield of step-based challenges. Read More

Open Access J Sports Med 2019 15;10:17-31. Epub 2019 Jan 15.

Department of Family Medicine, University of Alberta, Edmonton, AB, Canada,

Purpose: Asthma is the most common chronic disease among children. Exercise-induced bronchoconstriction which is common in asthmatic patients also occurs in individuals with no prior asthma diagnosis. Despite this and the fact that soccer is a high ventilation sport, there are no validated asthma management protocols in place for soccer coaches. Read More

Pan Afr Med J 2018 30;30:301. Epub 2018 Aug 30.

Department of Cardiology B, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.

The Kounis-Zavras syndrome is defined as the coincidental occurrence of acute coronary events and hypersensitivity reactions following an allergic reaction including a mast-cell degranulation of vasospastic mediators. This report describes a case of Kounis-Zavras syndrome in the setting of aspirin-induced asthma also known as Samter-Beer triad combining nasal polyps, asthma, and aspirin allergy leading to vasospasm and myocardial infarction. All physicians should be aware of The Kounis syndrome and always keep that unique clinical entity in mind to recognize it promptly and direct the therapy at suppressing the allergic reaction. Read More

Front Pediatr 2018 20;6:406. Epub 2018 Dec 20.

University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.

Asthma occurs across the life course. Its optimal treatment includes the use of personalized management plans that recognize the importance of co-morbidities including so-called "dysfunctional breathing." Such symptoms can arise as a result of induced laryngeal obstruction (ILO) or alterations in the mechanics of normal breathing called breathing pattern disorders. Read More

BMJ Open Respir Res 2018 18;5(1):e000358. Epub 2018 Dec 18.

School of Kinesiology, University of British Columbia, Vancouver, Canada.

Introduction: The eucapnic voluntary hyperpnoea (EVH) challenge is used to screen for exercise-induced bronchoconstriction. Several criteria have been proposed to determine the decrease in lung function (fall index, FI) following EVH. We compared three published FI calculation methods to determine if they affect the diagnostic classification. Read More

Rev Alerg Mex 2018 Oct-Dec;65(4):372-378

Universidad Quetzalcóatl en Irapuato, Guanajuato, México.

Background: The prevalence of allergic diseases markedly varies according to the geographical region.

Objective: To determine the prevalence of asthma, allergic rhinitis and atopic dermatitis in children of six and seven years of age.

Methods: Cross-sectional study that included a sample of almost 15 thousand children in five cities of Mexico. Read More

Int J Pediatr Otorhinolaryngol 2019 Mar 2;118:68-72. Epub 2018 Dec 2.

Division of Pediatric Otolaryngology, UPMC Children's Hospital of Pittsburgh, USA.

Introduction: Paradoxical vocal fold movement dysfunction (PVFMD) is a disorder in which the vocal folds involuntarily adduct during inspiration resulting in stridor, cough, dysphonia and dyspnea. Diagnosis of PVFMD is difficult given the episodic nature of the disorder and the often-normal laryngeal exam in between episodes. Moreover, additional sources of obstruction have been identified as sources of Periodic Occurrence of Laryngeal Obstruction (POLO). Read More

J Intellect Disabil Res 2018 Dec 19. Epub 2018 Dec 19.

Faculty of Health Science, University of Ontario Institute of Technology, Oshawa, Ontario, Canada.

Background: The prevalence of asthma among athletes with intellectual disabilities, and the asthma knowledge levels of their coaches, is unknown.

Methods: Special Olympics Canada athletes completed a demographic questionnaire (n = 208). Athletes who identified as having ever or current asthma completed the Asthma Control Questionnaire and the Mini Asthma Quality of Life Questionnaire and were measured for height, weight and lung function (n = 73). Read More

Respir Med 2018 Dec 21;145:48-56. Epub 2018 Oct 21.

Department of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.

Background: Individuals with obesity are more likely to develop asthma, but the exact mechanism is still uncertain and several hypotheses have been raised, such as the release of inflammatory mediators secreted by adipose tissue.

Objective: To assess the effects of weight loss in patients submitted to bariatric surgery on pulmonary and systemic inflammation.

Method: The study evaluated patients undergoing bariatric surgery (Roux-en-Y gastric bypass) with the diagnosis of asthma, except smokers. Read More

Allergy Asthma Clin Immunol 2018 8;14:81. Epub 2018 Nov 8.

3Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Colombo, Sri Lanka.

Background: The aetiology of anaphylaxis differs according to types of foods consumed, fauna and foliage and cultural practices. Although the aetiology of anaphylaxis in Western countries are well known, the causes in South Asian countries have not been reported. We sought to determine the causes of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka. Read More

Respir Physiol Neurobiol 2019 Jan 6;259:162-165. Epub 2018 Nov 6.

Department of Biomedical Sciences, College of Nursing, Public Authority for Applied Education & Training, Kuwait. Electronic address:

Asthmatic patients often suffer from bronchoconstriction or asthma following breathing hot air or exposure to exercise due to raises the core body temperature. However, the direct effect of heating airways has not been studied yet. The aim of this study is to investigate the effect of heating on tracheal and bronchiolar smooth muscles. Read More

Curr Allergy Asthma Rep 2018 Oct 26;18(12):72. Epub 2018 Oct 26.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, 60 Fenwood Rd., Building for Transformative Medicine, 5th Floor, Boston, MA, 02115, USA.

Purpose Of Review: This paper will review the pathophysiology, diagnosis, and treatment of exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis with an emphasis on novel studies published in the past several years.

Recent Findings: Exercise-induced anaphylaxis (EIAn) is a clinical syndrome characterized by anaphylaxis during or shortly after physical exertion. The syndrome is broadly grouped into two categories: exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis (FDEIAn). Read More

Pneumologie 2018 Oct 10;72(10):687-731. Epub 2018 Oct 10.

Facharztforum Fürth.

This document replaces the DGP recommendations published in 1998 and 2013. Based on recent studies and a consensus conference, the indications, choice and performance of the adequate exercise testing method and its necessary technical and staffing setting are discussed. Detailed recommendations are provided: for blood gas analysis and right heart catheterization during exercise, walk tests, spiroergometry, and stress echocardiography. Read More

Ann Allergy Asthma Immunol 2019 Jan 25;122(1):118-119. Epub 2018 Sep 25.

Cleveland Clinic Foundation, Cleveland, Ohio.

Ann Agric Environ Med 2018 Sep 17;25(3):428-432. Epub 2018 Apr 17.

Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.

Introduction: A growing number of epidemiological studies suggest that paracetamol, which is commonly used in children, may be a risk factor for asthma, allergic rhinitis, and atopic eczema.

Objective: The aim of this study was to determine and characterize the correlation between paracetamol use and asthma, allergic rhinitis, and atopic eczema symptoms in the Polish population.

Material And Methods: The study is part of the ECAP project involving the use of the ISAAC and ECRHS questionnaires. Read More

Respir Care 2019 Jan 25;64(1):71-76. Epub 2018 Sep 25.

Department of Pediatrics, Division of Pulmonology, Akron Children's Hospital, Akron, Ohio.

Background: A simple exercise test to evaluate for exercise-induced bronchoconstriction (EIB) is routinely ordered in pediatric patients with exercise-induced dyspnea. However, the utility of this test in establishing the cause of exercise-induced dyspnea is not thoroughly examined in the pediatric population. We sought to assess the efficiency of a simple EIB challenge test in finding the cause of exercise-induced dyspnea in pediatric patients referred to our tertiary center in the last 5 y. Read More

Clin Exp Allergy 2019 Jan 7;49(1):120-129. Epub 2018 Oct 7.

Molecular Allergology, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.

Background: Common wheat (Triticum aestivum) and durum wheat (T. turgidum) are both involved in Baker's asthma (BA) and food allergy (FA) including wheat-dependent exercise-induced asthma (WDEIA). However, allergens in durum wheat have not been described, and the over-expression of T. Read More

Braz J Phys Ther 2019 Jan - Feb;23(1):12-18. Epub 2018 Aug 23.

Postgraduate Studies in Physiotherapy Department, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil. Electronic address:

Objective: To assess the association between quality of life, asthma severity, sleep disorders and exercise capacity in children with asthma.

Methods: We evaluated 45 children with asthma of both sexes aged between 7 and 12 years, diagnosed by a pediatrician/pulmonologist and classified according to the IV Brazilian Guidelines for Asthma Management: severity (intermittent/mild and moderate/severe) and control (controlled, partially controlled and uncontrolled). Quality of life (QoL), presence of sleep disorders and exercise capacity were respectively assessed using the following instruments: Pediatric Asthma Quality of Life Questionnaire (PAQLQ); Sleep Disturbance Scale for Children (SDSC); and six-minute step test (6MST). Read More

Allergy 2018 Aug 24. Epub 2018 Aug 24.

Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Background: Wheezing illnesses among young children are common and are a risk factor for asthma. However, determinants of childhood bronchial reactivity, a key feature of asthma, are largely unknown. The aim of this study was to determine how patient characteristics during the first severe virus-induced wheezing episode are associated with pulmonary function at preschool age. Read More

Sci Adv 2018 Aug 17;4(8):eaar8602. Epub 2018 Aug 17.

Norwegian University of Life Sciences, Aas, Norway.

Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as celiac disease, wheat allergy, baker's asthma, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Establishing the content and distribution of the immunostimulatory regions in wheat has been hampered by the complexity of the wheat genome and the lack of complete genome sequence information. Read More

NPJ Prim Care Respir Med 2018 Aug 14;28(1):31. Epub 2018 Aug 14.

Global Respiratory Franchise, GSK, Middlesex, London, UK.

Exercise-induced bronchoconstriction (EIB) can occur in individuals with and without asthma, and is prevalent among athletes of all levels. In patients with asthma, symptoms of EIB significantly increase the proportion reporting feelings of fearfulness, frustration, isolation, depression and embarrassment compared with those without symptoms. EIB can also prevent patients with asthma from participating in exercise and negatively impact their quality of life. Read More

Rev Mal Respir 2018 Sep 7;35(7):759-775. Epub 2018 Aug 7.

Antenne médicale de prévention du dopage, EA 3450, service des examens de la fonction respiratoire et de l'aptitude à l'exercice médecine du sport, CHRU de Nancy Brabois, 54500 Vandœuvre-lès-Nancy, France.

Bronchial challenge with the direct bronchoconstrictor agent methacholine is commonly used for the diagnosis of asthma. The "Lung Function" thematic group of the French Pulmonology Society (SPLF) elaborated a series of guidelines for the performance and the interpretation of methacholine challenge testing, based on French clinical guideline methodology. Specifically, guidelines are provided with regard to the choice of judgment criteria, the management of deep inspirations, and the role of methacholine bronchial challenge in the care of asthma, exercise-induced asthma, and professional asthma. Read More

Ann Allergy Asthma Immunol 2018 Oct 27;121(4):451-457. Epub 2018 Jul 27.

Pediatric Unit, Department of Allergy, Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Clinical significance of small airway obstruction in mild pediatric asthma is unclear.

Objective: To evaluate small airway properties in children with mild to moderate asthmatic symptoms and the association of small airway function with asthma control and exercise-induced bronchoconstriction (EIB).

Methods: Children (5-10 years old) with recurrent wheezing (n = 42) or persistent troublesome cough (n = 16) and healthy controls (n = 19) performed impulse oscillometry (IOS), spirometry, and a multiple-breath nitrogen washout (MBNW) test. Read More

Front Physiol 2018 9;9:814. Epub 2018 Jul 9.

Exercise Physiology Unit, Department of Physiological Sciences, Faculty of Medicine and Health Sciences, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

In recent years, the altitude acclimatization responses elicited by short-term intermittent exposure to hypoxia have been subject to renewed attention. The main goal of short-term intermittent hypobaric hypoxia exposure programs was originally to improve the aerobic capacity of athletes or to accelerate the altitude acclimatization response in alpinists, since such programs induce an increase in erythrocyte mass. Several model programs of intermittent exposure to hypoxia have presented efficiency with respect to this goal, without any of the inconveniences or negative consequences associated with permanent stays at moderate or high altitudes. Read More

Electron Physician 2018 Jun 25;10(6):6920-6926. Epub 2018 Jun 25.

Consultant of Public Health, Saudi Board of Family Medicine, Northern Borders, Arar City, Saudi Arabia.

Background: Asthma is a common chronic disease in adolescents, and has led to a significant morbidity and disability. Few studies have estimated the prevalence of asthma in the Northern Borders Region of Saudi Arabia. Only limited data has been available about prevalence of asthma in adolescents' age. Read More

FASEB J 2018 Jul 19:fj201700338. Epub 2018 Jul 19.

Center for Nutrition and Metabolism, Children's Hospital Oakland Research Institute (CHORI), Oakland, California, USA.

Asthma in the obese is often severe, difficult to treat, and characterized by less eosinophilic inflammation than asthma in the nonobese. Obesity-associated metabolic dysregulation may be a causal factor. We previously reported that a nutrient- and fiber-dense bar [Children's Hospital Oakland Research Institute (CHORI)-bar], which was designed to fill gaps in poor diets, improved metabolism in healthy overweight/obese (OW/OB) adults. Read More

Contemp Clin Trials Commun 2018 Jun 9;10:177-189. Epub 2018 May 9.

Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Portugal.

Background: The effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2) the impact of an induced acute period of sedentary behavior on neuro-immune-endocrine status. Read More

Vet Clin North Am Equine Pract 2018 Aug;34(2):443-460

Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA. Electronic address:

The airways are the first part of the pathway in the oxygen transport chain that is critical to excellent athletic performance, and the lower airways are considered the final gatekeeper before oxygen enters the blood and carbon dioxide exits. Horses are blessed with large airways and lungs that allow them to be superb athletes, but the down side of this largesse on the part of evolution is that unless they are truly elite athletes they may withstand noninfectious disease of the lower respiratory tract for months to years before the owner or trainer notices. The two conditions of the lower respiratory tract that affect the athletic horse during exercise are exercise-induced pulmonary hemorrhage and inflammatory airway disease. Read More

Allergol Immunopathol (Madr) 2018 Nov - Dec;46(6):565-570. Epub 2018 Jul 5.

Immunoallergy Department, CUF Descobertas Hospital, Lisbon, Portugal.

Introduction: Lipid transfer proteins (LTPs) are panallergens found in many plant foods. They are a common cause of food-induced anaphylaxis (FIA) in adults living in the Mediterranean area. LTPs have also been proposed as a main cause of food-dependent exercise-induced anaphylaxis (FDEIA). Read More

Respir Med Case Rep 2018 19;24:138-142. Epub 2018 May 19.

Department of Pneumology, University Hospital Basel, Switzerland.

A 25 year old woman was referred to our center for further evaluation of an exercise-induced dyspnea. Moreover, the patient suffered from hoarseness and recurrent sinusitis and otitis. After initially finding nothing suspicious, a spiro-ergometry was performed. Read More

J Asthma 2018 Jun 29:1-8. Epub 2018 Jun 29.

a Aristotle University of Thessaloniki , Greece, Paediatric Pulmonology Unit, Hippokration Hospital , Thessaloniki , Greece.

Background: Inhaled Corticosteroids (ICS) are the cornerstone of asthma management in pediatric patients. However, in some cases, asthma is not adequately controlled on ICS alone. Long-acting beta-agonists (LABA) are one of the available additional therapies but their use has rarely been studied among children younger than 5 years. Read More

Front Physiol 2018 13;9:719. Epub 2018 Jun 13.

Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.

This study aimed to better understand how subjects with stable asthma and without exercise-induced bronchoconstriction respond to mild exercise. Breathing pattern, chest wall compartmental and operational volumes, and thoracoabdominal asynchrony were assessed in 11 stable asthmatic subjects and 10 healthy subjects at rest and during exercise in a cycle-ergometer through optoelectronic plethysmography. Dyspnea and sensation of leg effort were assessed through Borg scale. Read More

Patient Prefer Adherence 2018 15;12:1015-1023. Epub 2018 Jun 15.

Department of Physiotherapy, College of Medical and Health Sciences, Ahlia University, Manama, Kingdom of Bahrain.

Background: It has been documented that aerobic exercise may increase pulmonary functions and aerobic capacity, but limited data has evaluated a child's satisfaction and pediatric quality of life (PQoL) with exercise training.

Objectives: This study aimed to investigate the effects of moderate-intensity exercise training on asthmatic school-aged children.

Subjects And Methods: This study included 38 school-aged children with asthma (23 males and 15 females) aged between 8-12 years. Read More

J Sports Sci 2019 Jan 20;37(2):212-220. Epub 2018 Jun 20.

a Faculty of Health Sciences , University of Ontario Institute of Technology , Oshawa , ON , Canada.

The purpose was to compare the airway response to sprint interval exercise (SIE) and continuous exercise (CE) in active adults with exercise-induced bronchoconstriction (EIBC), and to compare ventilatory and oxygen delivery responses between adults with and without EIBC. Adults with EIBC (n = 8, 22.3 ± 3. Read More

Adv Drug Deliv Rev 2018 Aug 12;133:19-33. Epub 2018 Jun 12.

Clinical Professor, Central Clinical School, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

For the first 40 years of the 20th century treatment for asthma occurred in response to an asthma attack. The treatments were given by injection or orally and included the adrenergic agonists adrenalin/epinephrine and ephedrine and a phosphodiesterase inhibitor theophylline. Epinephrine became available as an aerosol in 1930. Read More

Data Brief 2018 Jun 5;18:1895-1899. Epub 2018 May 5.

Murayama Pediatrics, 3-2-33 Nagayoshi-Nagahara-Higashi Hirano-ku Osaka-shi, 547-0013 Osaka, Japan.

Food-dependent exercise-induced anaphylaxis (FDEIAn) is an anaphylactic reaction induced by physical exercise after ingestion of certain meals. FDEIAn is not very frequent, but recent case reports associated with various meals indicate an upward trend. Here, we report the data of various food specific IgEs and the clinical course of an experience with a patient who exhibited a unique FDEIAn reaction. Read More

Front Pediatr 2018 9;6:135. Epub 2018 May 9.

Pediatric Allergy and Pulmonology Units, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca Bio-health Research Institute, University of Murcia, Murcia, Spain.

Ther Adv Respir Dis 2018 Jan-Dec;12:1753466618777723

Nove de Julho University, Rua Vergueiro, 235/249 - Liberdade, São Paulo - SP, Brazil 01504-000.

Background: Asthma is characterized by hyperresponsiveness of the airways, and exercise-induced bronchospasm (EIB) is a symptom that limits a large proportion of asthmatic patients, especially children. Continuous positive airway pressure (CPAP) leads to a reduction in the reactivity of the airways. The aim of this study was to evaluate the effect of outpatient treatment with CPAP and bilevel pressure combined with respiratory physical therapy for children and adolescents with asthma following bronchial hyperresponsiveness caused by an exercise bronchoprovocation test. Read More

Allergol Int 2019 Jan 30;68(1):26-32. Epub 2018 May 30.

Department of Allergy, Tokyo Metropolitan Children's Medical Centre, Tokyo, Japan.

Background: Atopic dermatitis (AD) and exercise-induced asthma (EIA) are common in asthmatic children, and exercise is the most common trigger other than infection for acute onset asthma attack in children. We examined whether AD is related to exercise-induced wheezing (EIW), some proxy for EIA.

Methods: Japanese version of the International Study of Asthma and Allergies in Childhood questionnaires were used. Read More

Pediatr Int 2018 Aug;60(8):691-696

Department of Pediatrics, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Background: Exercise-induced bronchoconstriction (EIB) is diagnosed via exercise challenge on a treadmill, but such testing requires complex equipment and sufficient health-care resources. The fraction of exhaled nitric oxide (FeNO) test and mannitol bronchial provocation test (BPT) may serve as a surrogate for exercise testing.

Methods: We compared the diagnostic utilities of the FeNO test and mannitol BPT in predicting EIB in asthmatic children. Read More

Scand J Med Sci Sports 2018 Oct 7;28(10):2114-2122. Epub 2018 Jun 7.

Section of Integrative Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.

Due to a high prevalence of asthma and exercise-induced bronchoconstriction in elite athletes, there is a high use of beta -adrenoceptor agonists (beta -agonists) in the athletic population. While anabolic in rodents, no study has been able to detect hypertrophy in humans after chronic beta -agonist inhalation. We investigated whether inhaled beta -agonist, terbutaline, alters body composition and metabolic rate with and without concurrent exercise training in healthy young men. Read More

Physiother Theory Pract 2018 May 14:1-12. Epub 2018 May 14.

c Department of Sports medicine , The Norwegian School of Sport Sciences , Oslo , Norway.

Otherwise healthy adolescent athletes presenting with respiratory symptoms consistent with exercise-induced laryngeal obstruction (EILO) are frequently encountered in clinical practice. The symptoms are often incorrectly considered to result from exercise-induced asthma, and may be wrongly treated as such. Given the potential implications for health and performance if EILO is left untreated, a more comprehensive understanding of contributory mechanisms is essential in order to create appropriate treatment procedures. Read More

Respir Med 2018 05 3;138:102-106. Epub 2018 Apr 3.

Health Sciences Postgraduate Course, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil; Center for Research in Allergy and Clinical Immunology, Clinical Hospital, Federal University of Pernambuco, Recife, Brazil; Child and Adolescent Health Postgraduate Course, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.

Background: Respiratory complaints after exercise are common in patients with rhinitis. Exercise-induced bronchospasm (EIB) may be one of the causes.

Objectives: To evaluate EIB prevalence in a group of children and adolescents with allergic rhinitis, to compare the treadmill running (TR) and eucapnic voluntary hyperventilation (EVH) challenge methods as diagnostic tools and to assess the association between respiratory complaints on exercise and EIB. Read More

Ann Allergy Asthma Immunol 2018 Jul 27;121(1):69-76.e2. Epub 2018 Apr 27.

Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, California; Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Pediatrics, Stanford University School of Medicine, Stanford, California. Electronic address:

Background: Reliable prognostic markers for predicting severity of allergic reactions during oral food challenges (OFCs) have not been established.

Objective: To develop a predictive algorithm of a food challenge severity score (CSS) to identify those at higher risk for severe reactions to a standardized peanut OFC.

Methods: Medical history and allergy test results were obtained for 120 peanut allergic participants who underwent double-blind, placebo-controlled food challenges. Read More

Arq Bras Cardiol 2018 Mar;110(3):231-239

Faculdade Ciências Médicas - Minas Gerais, Belo Horizonte, MG, Brazil.

Background: Despite significant advances in understanding the pathophysiology and management of asthma, some of systemic effects of asthma are still not well defined.

Objectives: To compare heart function, baseline physical activity level, and functional exercise capacity in young patients with mild-to-moderate asthma and healthy controls.

Methods: Eighteen healthy (12. Read More

ERJ Open Res 2018 Apr 20;4(2). Epub 2018 Apr 20.

School of Sport and Exercise Sciences, University of Kent, Chatham, UK.

Our aim was to evaluate the prevalence of exercise-induced bronchoconstriction (EIB) in elite football players and assess subsequent impact of therapy on airway health and exercise performance. 97 male professional football players completed an airway health assessment with a eucapnic voluntary hyperpnoea (EVH) challenge to diagnose EIB. Players demonstrating a positive result (EVH) were prescribed inhaler therapy depending on severity, including inhaled corticosteroids and inhaled short-acting β-agonists, and underwent repeat assessment after 9 weeks of treatment. Read More

Br J Sports Med 2018 Sep 18;52(18):1211-1212. Epub 2018 Apr 18.

Department of Respiratory Medicine, Royal Brompton Hospital, London, UK.

Int J Immunogenet 2018 Jun 18;45(3):102-108. Epub 2018 Apr 18.

Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.

The Tie2 receptor is an important player in angiogenesis. The Tie2 mRNA and protein are abundantly expressed in the lungs and the associated pathway also has an important role in the development and function of the eye. Tie2 is encoded by the TEK gene in humans. Read More