Search Our Scientific Publications & Authors

Int J Environ Res Public Health 2022 Jul 26;19(15). Epub 2022 Jul 26.

Poddębice Health Care Centre, 99-200 Poddębice, Poland.

Exercise may trigger bronchoconstriction, especially in a group of athletes in whom bronchospasm during exercise is reported to occur more frequently than in nonathletes. The aim of this study was to determine the prevalence and environmental risk factors contributing to exercise-induced bronchoconstriction (EIB) in adolescent athletes. A prospective study was conducted among a group of 101 adolescent athletes who underwent spirometry, exercise challenge, fractional exhaled nitric oxide (FeNO) measurements, and allergy assessment. Read More

Environ Int 2022 Sep 13;167:107407. Epub 2022 Jul 13.

Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Chapel Hill, NC, United States. Electronic address:

Background: Over one-third of the U.S. population is exposed to unsafe levels of ozone (O). Read More

Allergy Asthma Immunol Res 2022 Jul;14(4):379-392

Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.

Purpose: ω-5 gliadin is the major allergen that causes wheat-dependent exercise-induced anaphylaxis (WDEIA). Recently, a missing mutant wheat cultivar at 1B chromosome and closely linked was bred. This cultivar (ω5D) has a deficiency in ω-5 and γ-gliadins as well as some low-molecular-weight glutenins. Read More

Allergy Asthma Immunol Res 2022 Jul;14(4):345-347

Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.

J Allergy Clin Immunol Pract 2022 Jul 6. Epub 2022 Jul 6.

Department of Public Health and Research, Occupational Environmental and Maritime Diseases Center, University Hospital of Brest, France.

Ann Am Thorac Soc 2022 Jul 8. Epub 2022 Jul 8.

The University of Queensland, 1974, Lung and Allergy Research Centre, Diamantina Institute, Brisbane, Queensland, Australia.

Rationale: Exercise is associated with improvements in asthma, however the mechanisms responsible are not clear. Exercise induces changes in systemic inflammation, and it is possible that these inflammatory effects extend to the airways of people with asthma. Studies in healthy adults suggest inflammatory responses are dependent on exercise intensity: while acute moderate exercise is anti-inflammatory, acute vigorous exercise appears to be neutral or pro-inflammatory. Read More

Pediatr Pulmonol 2022 Jul 6. Epub 2022 Jul 6.

Center for Research in Allergy and Clinical Immunology, Clinical Hospital, Federal University of Pernambuco, Recife, Brazil.

Introduction: Impulse oscillometry (IOS) parameters are obtained more easily and effortlessly in comparison to forced expiratory volume in the first second (FEV1).

Objective: To compare IOS parameters to FEV1 in exercise-induced bronchoconstriction (EIB) diagnosis.

Methods: Seventy-four (60. Read More

Allergy Asthma Clin Immunol 2022 Jul 5;18(1):61. Epub 2022 Jul 5.

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan Street, Wangfujing, Beijing, 100730, China.

Background: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a serious and potentially life-threatening form of wheat allergy. Further episodes can only be prevented by avoiding wheat ingestion or avoiding exercise after wheat intake. Anaphylaxis may recur in some patients post-diagnosis. Read More

Am J Physiol Lung Cell Mol Physiol 2022 08 5;323(2):L142-L151. Epub 2022 Jul 5.

Rutgers Institute for Translational Medicine and Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey.

Epinephrine (EPI), an endogenous catecholamine involved in the body's fight-or-flight responses to stress, activates α-adrenergic receptors (αARs) expressed on various organs to evoke a wide range of physiological functions, including vasoconstriction. In the smooth muscle of human bronchi, however, the functional role of EPI on αARs remains controversial. Classically, evidence suggests that EPI promotes bronchodilation by stimulating β-adrenergic receptors (βARs). Read More

Front Allergy 2022 31;3:864890. Epub 2022 May 31.

Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton, NSW, Australia.

Background: Airway hyperresponsiveness (AHR) is a key pathophysiological feature of asthma and causes exercise-induced bronchoconstriction (EIB). Indirect bronchial provocation tests (BPTs) (e.g. Read More

Pediatr Allergy Immunol 2022 06;33(6):e13808

Department of Paediatrics, Medisch Spectrum Twente, Enschede, The Netherlands.

Background: Exercise-induced bronchoconstriction (EIB) is a frequent and highly specific symptom of childhood asthma. Inhaled corticosteroids (ICS) are the mainstay of controller therapy for EIB and asthma; however, a proportion of asthmatic children and adolescents is less responsive to ICS. We hypothesized that a single dose response to ICS could function as a predictor for individual long-term efficacy of ICS. Read More

Allergy Asthma Clin Immunol 2022 Jun 11;18(1):49. Epub 2022 Jun 11.

Department of Food Science, Kyoto Women's University, 35 Kitahiyoshi-cho, Imakumano, Higashiyama-ku, Kyoto, 605-8501, Japan.

Background: The Rosaceae family includes fruits, such as peach, apple, Japanese apricot, cherry (Prunoideae subfamily), and strawberry (Rosoideae subfamily). The allergens responsible for Rosaceae fruit allergies have been reported to include Bet v 1 and profilin, which mainly cause oral symptoms, and lipid transfer protein (LTP). Recently, gibberellin-regulated protein (GRP) has been identified as an allergen that induces generalized symptoms in peach-, orange-, and plum-related allergies. Read More

J Allergy Clin Immunol Pract 2022 May 30. Epub 2022 May 30.

Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo, Brazil. Electronic address:

Background: The effects of high-intensity interval training (HIIT) on dyspnea and aerobic fitness in adults with asthma are poorly understood.

Objective: To compare constant-load exercise (CLE) versus HIIT for improvements in dyspnea symptoms and clinical control in adults with moderate-to-severe asthma.

Methods: Participants were randomized into 2 groups: CLE (n = 27; started with 70% of maximal watts [Wmax] obtained during cardiopulmonary exercise testing [CPET]) and HIIT (n = 28; started with 80% and increased until 140% Wmax). Read More

Br J Sports Med 2022 May 27. Epub 2022 May 27.

Medical and Scientific Department, International Olympic Committee, Lausanne, Switzerland.

Acute respiratory illness (ARill) is common and threatens the health of athletes. ARill in athletes forms a significant component of the work of Sport and Exercise Medicine (SEM) clinicians. The aim of this consensus is to provide the SEM clinician with an overview and practical clinical approach to non-infective ARill in athletes. Read More

PLoS One 2022 26;17(5):e0268969. Epub 2022 May 26.

Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

The current cut-off value for diagnosing exercise-induced bronchoconstriction (EIB) in adults-percent fall in FEV1 (ΔFEV1) ≥ 10% after exercise challenge test (ECT)-has low specificity and weak evidences. Therefore, this study aimed to identify the cut-off value for EIB that provides the highest diagnostic sensitivity and specificity. Participants who underwent the ECT between 2007 and 2018 were categorized according to ΔFEV1: definite EIB (ΔFEV1 ≥ 15%), borderline (10% ≤ ΔFEV1 < 15%), and normal (ΔFEV1 < 10%). Read More

J Allergy Clin Immunol Pract 2022 07 20;10(7):1778-1783. Epub 2022 May 20.

Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Ill.

Background: National Heart, Lung, and Blood Institute guidelines recommend regular physical activity (PA) for patients with asthma. Health care provider (HCP) counseling represents an effective approach to optimizing patient PA. However, current exercise rates among asthma patients are suboptimal, which suggests that counseling may be improved. Read More

J Asthma Allergy 2022 16;15:633-643. Epub 2022 May 16.

Department of Allergy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health; Key Laboratory of Major Diseases in Children, Ministry of Education; National Clinical Research Center for Respiratory Diseases, Beijing, People's Republic of China.

Purpose: Pollen sensitization is increasing in children. However, there is little evidence regarding the characteristics of anaphylaxis in individuals with pollen sensitization.

Patients And Methods: We conducted a retrospective study of patients with anaphylaxis combined with pollen sensitization who attended an allergy department in a tertiary children's hospital from 2014 to 2021. Read More

Int J Dermatol 2022 May 14. Epub 2022 May 14.

Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

BJGP Open 2022 Aug 9. Epub 2022 Aug 9.

Asthma UK Centre for Applied Research, (AUKCAR) Wolfson Institute of Population Health, Queen Mary University of London, London, UK

Background: Engagement with exercise in adults with asthma is suboptimal. Limited information is available regarding factors affecting engagement with exercise.

Aim: To explore experiences of exercise and linked unmet needs in adults with asthma. Read More

Allergy 2022 Apr 20. Epub 2022 Apr 20.

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Faculty of Medicine, University of Southampton, Southampton, UK.

This rapid review summarizes the most up to date evidence about the risk factors for severe food-induced allergic reactions. We searched three bibliographic databases for studies published between January 2010 and August 2021. We included 88 studies and synthesized the evidence narratively, undertaking meta-analysis where appropriate. Read More

Sci Rep 2022 04 16;12(1):6389. Epub 2022 Apr 16.

Traslational Research In Airway Diseases Group (TRIAD), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

Asthma and rhinitis often co-exist in the same patient. Although some authors observed a higher prevalence and/or greater severity of asthma in patients with rhinitis, this view is not homogeneous and the debate continues. The aim of our study is to describe the prevalence of rhinitis in children and adolescents and to analyse their relationship with the prevalence of asthma. Read More

Int J Environ Res Public Health 2022 04 3;19(7). Epub 2022 Apr 3.

Department of Health Promotion Sciences, Hudson College of Public Health, University of Oklahoma Health Sciences Center, 801 N.E. 13th Street, Oklahoma City, OK 73104, USA.

Little is known about the cleaning products used by early care and education programs that contribute to childhood asthma, particularly in Oklahoma where rates of uncontrolled asthma are higher than national rates (60.0% vs. 50. Read More

Eur J Appl Physiol 2022 Jun 7;122(6):1473-1484. Epub 2022 Apr 7.

Swedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden.

Purpose: Cold air exposure is associated with increased respiratory morbidity and mortality. Repeated inhalation of cold and dry air is considered the cause of the high prevalence of asthma among winter endurance athletes. This study assessed whether a heat- and moisture-exchanging breathing device (HME) attenuates airway responses to high-intensity exercise in sub-zero temperatures among healthy subjects. Read More

Pediatr Pulmonol 2022 06 22;57(6):1401-1415. Epub 2022 Apr 22.

Department of Pediatrics, University of Alberta, Edmonton, Canada.

Inducible laryngeal obstruction (ILO) in children is underrecognized. This systematic review characterizes the scientific evidence on the impact of pediatric ILO diagnosis and treatment on asthma medication use. This review, registered with PROSPERO (CRD42020209168), utilized database searches in MEDLINE, EMBASE, CINAHL, and Web of Science from inception to October 2020. Read More

Sci Rep 2022 03 29;12(1):4599. Epub 2022 Mar 29.

Sensory Cloud, 650 East Kendall St, Cambridge, MA, USA.

Dehydration of the upper airways increases risks of respiratory diseases from COVID-19 to asthma and COPD. We find in human volunteer studies involving 464 human subjects in Germany, the US, and India that respiratory droplet generation increases by up to 4 orders of magnitude in dehydration-associated states of advanced age (n = 357), elevated BMI-age (n = 148), strenuous exercise (n = 20) and SARS-CoV-2 infection (n = 87), and falls with hydration of the nose, larynx and trachea by calcium-rich hypertonic salts. We also find in a protocol of exercise-induced airway dehydration that hydration of the airways by calcium-rich salts increases oxygenation relative to a non-treatment control (P < 0. Read More

Sports (Basel) 2022 Mar 2;10(3). Epub 2022 Mar 2.

MINT, University Angers, Inserm, CNRS, SFR ICAT, F-49000 Angers, France.

The use of short-acting beta-2 agonists (SABAs) is more common in elite athletes than in the general population, especially in endurance sports. The World Anti-Doping Code places some restrictions on prescribing inhaled β2-agonists. These drugs are used in respiratory diseases (such as asthma) that might reduce athletes' performances. Read More

Front Pediatr 2022 22;10:800193. Epub 2022 Feb 22.

Department of Paediatrics, Medisch Spectrum Twente, Enschede, Netherlands.

Exercise induced bronchial (EIB) constriction is a common and highly specific feature of pediatric asthma and should be diagnosed with an exercise challenge test (ECT). The impact of EIB in asthmatic children's daily lives is immense, considering the effects on both physical and psychosocial development. Monitoring childhood asthma by ECT's can provide insight into daily life disease burden and the control of asthma. Read More

J Appl Physiol (1985) 2022 04 24;132(4):1031-1040. Epub 2022 Feb 24.

Laboratoire J. A. Dieudonné, UMR CNRS 7351, Université Côte d'Azur, Nice, France.

In healthy subjects, at low minute ventilation (V̇e) during physical exercise, the water content and temperature of the airways are well regulated. However, with the increase in V̇e, the bronchial mucosa becomes dehydrated and epithelial damage occurs. Our goal was to demonstrate the correspondence between the ventilatory threshold inducing epithelial damage, measured experimentally, and the dehydration threshold, estimated numerically. Read More

Lung 2022 04 23;200(2):229-236. Epub 2022 Feb 23.

Center for Research in Allergy and Clinical Immunology, Hospital das Clínicas, Universidade Federal de Pernambuco, Rua Luiz Guimarães, 411, apto 301-a, CEP-52061-160, Poço da Panela, Recife, Brazil.

Purpose: Exercise-induced bronchoconstriction (EIB) affects approximately 50% of young asthma patients, impairing their participation in sports and physical activities. Eucapnic voluntary hyperpnea (EVH) is an approved surrogate challenge to exercise for objective EIB diagnosis, but the required minimum target hyperventilation rates remain unexplored in this population. This study aimed to evaluate the association between the achieved ventilation rates (VRs) during a challenge and EIB-compatible response (EIB-cr) in young asthma patients. Read More

Br J Sports Med 2022 Jun 22;56(11):622-629. Epub 2022 Feb 22.

Department of Pediatric and Adolescent Medicine, Haukeland Universityhospital, Bergen, Norway.

Exercise-induced laryngeal obstruction (EILO) is caused by paradoxical inspiratory adduction of laryngeal structures during exercise. EILO is an important cause of upper airway dysfunction in young individuals and athletes, can impair exercise performance and mimic lower airway dysfunction, such as asthma and/or exercise-induced bronchoconstriction. Over the past two decades, there has been considerable progress in the recognition and assessment of EILO in sports medicine. Read More