178,259 results match your criteria Asthma


[Bronchial asthma and obstructive sleep apnea].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):414-415

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.005DOI Listing
February 2019
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Effects of aerobic exercise on molecular aspects of asthma: involvement of SOCS-JAK-STAT.

Exerc Immunol Rev 2019 ;25:50-62

Universidade Brasil, Post-graduation Program in Bioengineering and in Biomedical Engineering, Campus Itaquera, Rua Carolina Fonseca 235, São Paulo - SP, Brazil, 08230-030. Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Rua Pedro Ernesto 240, São José dos Campos - SP, Brazil, 12245-520. Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo (UNIFESP), Campus Baixada Santista, Av. Ana Costa, 95 - Vila Mathias - Santos/SP - CEP: 11060-001.

Background: Aerobic training (AT) decreases airway inflammation in asthma, but the underlying cellular and molecular mechanisms are not completely understood. Thus, this study evaluated the participation of SOCS-JAK-STAT signaling in the effects of AT on airway inflammation, remodeling and hyperresponsiveness in a model of allergic airway inflammation.

Methods: C57Bl/6 mice were divided into Control (Co), Exercise (Ex), HDM (HDM), and HDM+Exercise (HDM+ Ex). Read More

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January 2019

Spatiotemporal Variations in Ambient Ultrafine Particles and the Incidence of Childhood Asthma.

Am J Respir Crit Care Med 2019 Feb 20. Epub 2019 Feb 20.

McGill University Department of Epidemiology Biostatistics and Occupational Health, 213585, Montreal, Quebec, Canada.

Rationale: Little is known regarding the impact of ambient ultrafine particles (<0.1 μm) (UFPs) on childhood asthma development.

Objective: To examine the association between prenatal and early postnatal life exposure to UFPs and development of childhood asthma. Read More

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http://dx.doi.org/10.1164/rccm.201810-1976OCDOI Listing
February 2019

A review of dupilumab in the treatment of atopic diseases.

Hum Vaccin Immunother 2019 Feb 20. Epub 2019 Feb 20.

a Department of Dermatology , University of California, San Francisco , San Francisco.

Dupilumab is a fully human monoclonal IgG4 antibody directed against the alpha subunit of the IL-4 receptor and prevents the signaling of IL-4 and IL-13, two type 2 cytokines known to be important drivers of atopic diseases. In March of 2017, the United States Food and Drug Administration (FDA) approved dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults that is uncontrolled with topical medications, becoming the first biologic agent approved to treat this chronic skin condition. In October of 2018, Dupilumab received approval by the FDA as an add-on maintenance therapy in patients with moderate-to-severe asthma aged 12 years or older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma. Read More

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http://dx.doi.org/10.1080/21645515.2019.1582403DOI Listing
February 2019

Cellular Senescence in the Lung Across the Age Spectrum.

Am J Physiol Lung Cell Mol Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, United States.

Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines, growth factors and remodeling proteins (senescence associated secretory phenotype; SASP) that have autocrine and paracrine effects on the tissue microenvironment. SASP can promote remodeling, inflammation, infectious susceptibility, angiogenesis and proliferation, while hindering tissue repair and regeneration. While the role of senescence and contributions of senescent cells are increasingly recognized in the context of aging and a variety of disease states, relatively less is known regarding the portfolio and influences of senescent cells in normal lung growth and aging per se, or in the induction or progression of lung diseases across the age spectrum such as bronchopulmonary dysplasia, asthma, COPD, or pulmonary fibrosis. Read More

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http://dx.doi.org/10.1152/ajplung.00424.2018DOI Listing
February 2019

Severe Eosinophilic Allergic Asthma Responsive to Mepolizumab After Failure of 2 Consecutive Biologics.

J Investig Allergol Clin Immunol 2019 Feb;29(1):79-81

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0340DOI Listing
February 2019

Wheat Anaphylaxis due to Skin Contact in an Exclusively Breastfed 2.5-Month-Old Infant.

J Investig Allergol Clin Immunol 2019 Feb;29(1):62-64

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.18176/jiaci.0332DOI Listing
February 2019

Factors Affecting the Food Allergy Profile of Children From Schools in Hortaleza District, Madrid, Spain.

J Investig Allergol Clin Immunol 2019 Feb;29(1):60-62

Unidad de Estadística, Secretaría Adjunta de Informática, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0330DOI Listing
February 2019

Dilemmas and New Paradigms in Asthma Management.

J Investig Allergol Clin Immunol 2019 Feb;29(1):15-23

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ) and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.

Asthma is one of the most common inflammatory diseases in the world. The main goal of treatment is to achieve optimal control. Although every patient is different, clinical practice guidelines can help physicians to manage the disease. Read More

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http://dx.doi.org/10.18176/jiaci.0345DOI Listing
February 2019

The muscarinic antagonist gallamine induces proliferation of airway smooth muscle cells regardless of the cell phenotype.

Pharmacol Rep 2018 Oct 23;71(2):225-232. Epub 2018 Oct 23.

Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Thessaly, BIOPOLIS, Larissa, Greece. Electronic address:

Background: Muscarinic receptor antagonists are a usual treatment for chronic airway diseases, with increased bronchoconstriction, like asthma and chronic obstructive pulmonary disease. These diseases are usually accompanied by airway remodeling, involving airway smooth muscle cell (ASMC) proliferation. The purpose of this study was to examine the effect of the muscarinic receptor modulator gallamine on rabbit tracheal ASMC proliferation. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.10.010DOI Listing
October 2018

Severe asthma and bronchiectasis.

J Asthma 2019 Feb 20:1-5. Epub 2019 Feb 20.

a Department of Pneumology , Hospital Universitario Central de Asturias , Oviedo , Spain.

Objective: The aim of our study was to determine the tomographic findings and prevalence of bronchiectasis in our population of patients with severe asthma, and to identify factors associated with the presence of bronchiectasis in these patients.

Materials And Methods: We retrospectively collected data from the medical histories of patients referred to the asthma unit of our hospital, with a diagnosis of severe asthma between 2015 and 2017. Patients with ABPA, cystic fibrosis, immunodeficiency or systemic disease were excluded. Read More

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http://dx.doi.org/10.1080/02770903.2019.1579832DOI Listing
February 2019

Relationship between asthma status and antibody response pattern to 23-valent pneumococcal vaccination.

J Asthma 2019 Feb 20:1-10. Epub 2019 Feb 20.

h Department of Pediatric and Adolescent Medicine/Internal Medicine , Mayo Clinic , Rochester , MN , USA.

Objective: Asthma poses an increased risk for serious pneumococcal disease, but little is known about the influence of asthma status on the 23-valent serotype-specific pneumococcal antibody response. We examined differences in antibody titers between pre- and post-vaccination with 23-valent pneumococcal polysaccharide vaccine (PPSV-23) in relation to asthma status.

Methods: Asthma status was retrospectively ascertained by the Predetermined Asthma Criteria in an existing vaccine cohort through comprehensive medical record review. Read More

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http://dx.doi.org/10.1080/02770903.2019.1575394DOI Listing
February 2019

Mold Sensitization in Asthmatic and Non-asthmatic Subjects Diagnosed with Extract-Based Versus Component-Based Allergens.

Adv Exp Med Biol 2019 Feb 20. Epub 2019 Feb 20.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.

Asthmatic patients are suspected of having a higher risk of mold sensitization. Thus, precise diagnosis of fungal sensitization is important. Mold allergen extracts are difficult to standardize, but component-resolved allergy diagnosis may be an alternative to replace extract-based tests. Read More

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http://dx.doi.org/10.1007/5584_2019_342DOI Listing
February 2019

Inhaled steroids associated with decreased macrophage markers in nonasthmatic individuals with sickle cell disease in a randomized trial.

Ann Hematol 2019 Feb 20. Epub 2019 Feb 20.

Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1620, New York, NY, 10029-6574, USA.

Inhaled mometasone was shown to improve pain scores and decrease soluble vascular cell adhesion molecule (sVCAM) concentration in a randomized controlled trial of nonasthmatic patients with sickle cell disease. We sought to explore potential changes in systemic inflammation as a mechanism underlying this effect. Serum samples from 41 trial participants (15 placebo- and 26 mometasone-treated) were analyzed using a 92 inflammatory marker panel at baseline and after 8 weeks of mometasone therapy. Read More

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http://dx.doi.org/10.1007/s00277-019-03635-9DOI Listing
February 2019

Elevated expression of microRNA-378 in children with asthma aggravates airway remodeling by promoting the proliferation and apoptosis resistance of airway smooth muscle cells.

Exp Ther Med 2019 Mar 28;17(3):1529-1536. Epub 2018 Dec 28.

Department of Pediatrics, Maternity and Child Health Care Hospital of Zibo City, Zibo, Shandong 255029, P.R. China.

The present study determined the expression of microRNA (miR)-378 in the peripheral blood and lung tissues of children with asthma, and investigated its effect and mechanism of action on the biological functions of airway smooth muscle cells. A total of 23 asthmatic children and 15 healthy children were included in the study. Peripheral blood and tissues were obtained from asthmatic children. Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.7141
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http://dx.doi.org/10.3892/etm.2018.7141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364182PMC
March 2019
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Codonopsis lanceolata attenuates allergic lung inflammation by inhibiting Th2 cell activation and augmenting mitochondrial ROS dismutase (SOD2) expression.

Sci Rep 2019 Feb 19;9(1):2312. Epub 2019 Feb 19.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.

Allergic asthma is a chronic inflammatory disease induced by the inhalation of allergens, which trigger the activation of T helper type 2 (Th2) cells that release Th2 cytokines. Recently, herbal medicines are being considered a major source of novel agents to treat various diseases. In the present study, we evaluated the anti-asthmatic effects of a Codonopsis lanceolata extract (CLE) and the mechanisms involved in its anti-inflammatory effects. Read More

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http://dx.doi.org/10.1038/s41598-019-38782-6DOI Listing
February 2019

Qualitative study to identify ethnicity-specific perceptions of and barriers to asthma management in South Asian and White British children with asthma.

BMJ Open 2019 Feb 19;9(2):e024545. Epub 2019 Feb 19.

Mary Seacole Research Centre, DeMonfort University, Leicester, UK.

Objective: This paper draws on the data from the Management and Interventions for Asthma (MIA) study to explore the perceptions and experiences of asthma in British South Asian children using semi-structured interviews. A comparable cohort of White British children was recruited to identify whether any emerging themes were subject to variation between the two groups so that generic and ethnicity-specific themes could be identified for future tailored intervention programmes for South Asian children with asthma.

Setting: South Asian and White British children with asthma took part in semi-structured interviews in Leicester, UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024545DOI Listing
February 2019

Associations between statins and coronary artery disease and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome: A time-dependent regression study.

Atherosclerosis 2019 Feb 11;283:61-68. Epub 2019 Feb 11.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:

Backgound And Aims: We aimed at determining the effects of statin use on coronary artery disease (CAD) and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).

Methods: We retrospectively enrolled patients with ACOS treated with (N = 916) and without (N = 6338) statins. The cumulative incidence of CAD and stroke (ischemic and hemorrhagic) was analyzed through time-dependent Cox proportional regression. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.007DOI Listing
February 2019

Evaluation of Healthy User Effects With Metformin and Other Oral Antihyperglycemia Medication Users in Adult Patients With Type 2 Diabetes.

Can J Diabetes 2018 Dec 13. Epub 2018 Dec 13.

School of Public Health, University of Alberta, Edmonton, Alberta, Canada; Alliance for Canadian Health Outcomes Research in Diabetes, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Objectives: Healthy user bias, whereby health-seeking patients are more likely to initiate preventive therapies and engage in healthy lifestyle behaviours, is well known in observational studies, particularly with statins. However, its influence in studies of oral antihyperglycemic therapies is unknown. We sought to explore the healthy user effects in metformin users vs. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.12.001DOI Listing
December 2018

Psychotic experiences in the context of mood and anxiety disorders and their associations with health outcomes among people of color in the United States.

J Psychosom Res 2019 Mar 17;118:27-33. Epub 2019 Jan 17.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain. Electronic address:

Background: Psychotic experiences appear to increase risk for health outcomes above and beyond mood/anxiety disorders. However, existing studies that have found this association were conducted mostly in low- and middle-income countries, calling for more studies to explore the association in other contexts, such as the U.S. Read More

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http://dx.doi.org/10.1016/j.jpsychores.2019.01.004DOI Listing

[Association of cytoplasmic phospholipase A2 gene polymorphism with bronchial asthma and response to montelukast in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):155-160

Department of West District General Internal Medicine, Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou 450000, China.

Objective: To study the association of cytoplasmic phospholipase A2 (PLA2G4) rs932476 polymorphism with the development of bronchial asthma and the response to montelukast, a leukotriene receptor antagonist, in children.

Methods: A total of 128 children with bronchial asthma were enrolled as case group, and 100 healthy children were enrolled as control group. The genotype and allele frequencies of PLA2G4 rs932476 were compared between the two groups. Read More

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February 2019

Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung.

Clin Epigenetics 2019 Feb 19;11(1):32. Epub 2019 Feb 19.

Respiratory Cellular and Molecular Biology, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.

In utero exposure to tobacco products, whether maternal or environmental, have harmful effects on first neonatal and later adult respiratory outcomes. These effects have been shown to persist across subsequent generations, regardless of the offsprings' smoking habits. Established epigenetic modifications induced by in utero exposure are postulated as the mechanism underlying the inherited poor respiratory outcomes. Read More

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http://dx.doi.org/10.1186/s13148-019-0631-3DOI Listing
February 2019

Discussions About Antibiotics During Adolescent Asthma Visits: Implications for Providers.

Clin Pediatr (Phila) 2019 Feb 19:9922819829033. Epub 2019 Feb 19.

1 University of North Carolina at Chapel Hill, NC, USA.

Children with asthma are exposed to antibiotics more frequently than their peers. The quality of provider-patient discussion about antibiotics is unknown. In this secondary data analysis, we reviewed existing transcripts of audiotaped adolescent asthma visits using a standardized coding sheet to analyze the quality of communication about antibiotics. Read More

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http://dx.doi.org/10.1177/0009922819829033DOI Listing
February 2019

IgE Downregulates PTEN through MicroRNA-21-5p and Stimulates Airway Smooth Muscle Cell Remodeling.

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Pneumology & Pulmonary Cell Research, Departments of Internal Medicine & Biomedicine, University & University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

The patho-mechanism leading to airway wall remodeling in allergic asthma is not well understood and remodeling is resistant to therapies. This study assessed the effect of immunoglobulin E (IgE) in the absence of allergens on human primary airway smooth muscle cell (ASMC) remodeling in vitro. ASMCs were obtained from five allergic asthma patients and five controls. Read More

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http://dx.doi.org/10.3390/ijms20040875DOI Listing
February 2019

Recent advances in aerosolised drug delivery.

Biomed Pharmacother 2019 Feb 16;112:108601. Epub 2019 Feb 16.

Department of pharmaceutics, I.S.F. College of Pharmacy, Moga, Punjab, India. Electronic address:

Pulmonary route is extensively studied for the diagnosis and treatment of pulmonary and extra pulmonary disease conditions such as asthma, tuberculosis, emphysema, and bronchitis. Formulation design, inhalation device and particle size play key role in determining the aerosol performance. The lack of desired clinical outcome along with the problem regarding efficacy or any adverse drug effect may arise due to improper training and education in use of the device to control the actuation and aerosol inhalation. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108601DOI Listing
February 2019

The effect of passive smoking on exhaled nitric oxide in asthmatic children.

Nitric Oxide 2019 Feb 16. Epub 2019 Feb 16.

Social Medicine Institute, Department of Social and Preventive Medicine, Medical University of Lodz, Poland.

To date, some studies suggest that passive smoking (PS) may be an important determinant of FeNO levels in children but sill there is a need of investigations using objective methods of PS exposure. The aim of our study was to examine the effect of PS, measured by urine cotinine levels, on FeNO and lung function (FEV1) in allergic and non-allergic asthmatic children. METHODS: It was a prospective, non-interventional study. Read More

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http://dx.doi.org/10.1016/j.niox.2019.01.012DOI Listing
February 2019

Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized Xe-Ventilation MRI.

AJR Am J Roentgenol 2019 Feb 19:1-8. Epub 2019 Feb 19.

6 Department of Radiology and Nuclear Medicine, Cantonal Hospital, Lucerne, Switzerland.

Objective: The objective of our study was to identify the magnitude and distribution of ventilation defect scores (VDSs) derived from hyperpolarized (HP) Xe-MRI associated with clinically relevant airway obstruction.

Materials And Methods: From 2012 to 2015, 76 subjects underwent HP Xe-MRI (48 healthy volunteers [mean age ± SD, 54 ± 17 years]; 20 patients with asthma [mean age, 44 ± 20 years]; eight patients with chronic obstructive pulmonary disease [mean age, 67 ± 5 years]). All subjects underwent spirometry 1 day before MRI to establish the presence of airway obstruction (forced expiratory volume in 1 second-to-forced vital capacity ratio [FEV/FVC] < 70%). Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20036
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http://dx.doi.org/10.2214/AJR.18.20036DOI Listing
February 2019
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Tobacco Use Worldwide: Legislative Efforts to Curb Consumption.

Ann Glob Health 2018 Nov 5;84(4):571-579. Epub 2018 Nov 5.

Ciberes, ES.

Tobacco smoking is recognized as a major preventable cause of disease worldwide and is linked to 6 million deaths annually, 30% of which are due to cancer. The negative health consequences of smoking currently represent one of the greatest public health challenges. Secondhand smoke, declared carcinogenic by the International Agency for Research on Cancer in 2004, is also a major source of morbidity and premature death in nonsmokers, particularly children. Read More

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http://dx.doi.org/10.9204/aogh.2362DOI Listing
November 2018

Pharmacokinetics, Safety, and Tolerability of Tezepelumab (AMG 157) in Healthy and Atopic Dermatitis Adult Subjects.

Clin Pharmacol Ther 2019 Feb 19. Epub 2019 Feb 19.

BioMarin Pharmaceutical Inc, Novato, California, USA.

Tezepelumab (AMG 157) is a monoclonal antibody that targets thymic stromal lymphopoietin (TSLP) and has shown benefits in treating asthma. We assessed the safety, tolerability, and pharmacokinetics of single- and multiple-ascending doses in two randomized, double-blind, placebo-controlled Phase 1 studies. Healthy and atopic dermatitis subjects were enrolled in the single-dose study, and healthy subjects in the multiple-dose study. Read More

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http://dx.doi.org/10.1002/cpt.1401DOI Listing
February 2019

Asthma with multiple allergic comorbidities is associated with complete response to omalizumab.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

AP-HP, Groupe hospitalier Trousseau, La Roche Guyon, Centre de l'Asthme et des Allergies, Paris, France.

Patients with severe asthma constitute a heterogeneous population, and different phenotypes have been identified both in adults and children. Severe asthma affects 4.5% of children with current asthma. Read More

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http://dx.doi.org/10.1111/cea.13373DOI Listing
February 2019

Clinical Efficacy, Safety and Tolerability of a New Subcutaneous Immunoglobulin 16.5% (Octanorm [Cutaquig®]) in the Treatment of Patients With Primary Immunodeficiencies.

Front Immunol 2019 4;10:40. Epub 2019 Feb 4.

Department of Clinical Immunology and Allergology, St Anne's University Hospital in Brno, Faculty of Medicine, Masaryk University, Brno, Czechia.

Subcutaneously administered immunoglobulin (SCIG) is increasingly used to treat patients with primary immunodeficiencies (PIDs). Octanorm (marketed as cutaquig® in USA and Canada) is a new 16.5% solution of human SCIG, manufactured by a process based on that of the intravenous preparation (IVIG) octagam®. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369354PMC
February 2019

The role of oral magnesium supplements for the management of stable bronchial asthma: a systematic review and meta-analysis.

NPJ Prim Care Respir Med 2019 Feb 18;29(1). Epub 2019 Feb 18.

King Saud bin Abdul-Aziz University for Health Sciences; National & Gulf Center for Evidence Based Health Practice, King Abdullah International Medical Research Center, Family Medicine & Primary Healthcare Department, King Abdul-Aziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.

Asthma is a chronic lung disease characterized by airway inflammation and hyper-responsiveness of airway smooth muscles. There is growing evidence that magnesium may have a role in managing asthma through its dual effect as an anti-inflammatory and bronchodilating agent. To assess the efficacy of oral magnesium supplements in chronic asthmatic patients. Read More

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http://dx.doi.org/10.1038/s41533-019-0116-zDOI Listing
February 2019

A Simple Protocol to Stratify Pulmonary Risk Reduces Complications After Total Joint Arthroplasty.

J Arthroplasty 2019 Jan 29. Epub 2019 Jan 29.

Department of Orthopaedic Surgery, Rothman Orthopaedics at Thomas Jefferson University, Egg Harbor Township, NJ.

Background: Pulmonary complications after total joint arthroplasty are a burden to patients and the healthcare system. The aim of this study is to demonstrate the effectiveness of a pulmonary screening questionnaire and intervention protocol developed at our institution to prevent pulmonary complications.

Methods: Between 2010 and 2015, 7658 consecutive total joint arthroplasty patients at our institution were reviewed. Read More

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http://dx.doi.org/10.1016/j.arth.2019.01.048DOI Listing
January 2019

Effect of food intake and ambient air pollution exposure on ankylosing spondylitis disease activity.

Adv Rheumatol 2019 Feb 18;59(1). Epub 2019 Feb 18.

Molecular immunology research center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by axial arthritis. The genetic-environmental factors seem to be involved in the pathogenesis of the disease and the disease debilitates patients during the most productive stages of their lives. The aim of this study was to examine the relationships between two environmental factors, diet and air pollution with disease activity and functional impairment in AS. Read More

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http://dx.doi.org/10.1186/s42358-019-0051-2DOI Listing
February 2019

Impact of two oral doses of 100,000 IU of vitamin D in preschoolers with viral-induced asthma: a pilot randomised controlled trial.

Trials 2019 Feb 18;20(1):138. Epub 2019 Feb 18.

Clinical Research and Knowledge Transfer Unit on Childhood Asthma, Research Centre, Sainte-Justine University Health Centre, Montreal, Quebec, Canada.

Background: New evidence supports the use of supplemental vitamin D in the prevention of exacerbation of asthma; however, the optimal posology to sufficiently raise serum levels while maximising adherence is unclear. The objective was to ascertain the efficacy of high-dose vitamin D in increasing serum vitamin D in preschoolers with asthma and provide preliminary data on safety and efficacy outcomes.

Methods: We conducted a 7-month, triple-blind, randomised, placebo-controlled, pilot trial of children aged 1-5 years with viral-induced asthma. Read More

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http://dx.doi.org/10.1186/s13063-019-3184-zDOI Listing
February 2019

Efficacy and safety of AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, in patients with asthma: a phase 2a randomized, double blind, placebo-controlled crossover trial.

Respir Res 2019 Feb 18;20(1):37. Epub 2019 Feb 18.

Respiratory, Inflammation and Autoimmunity Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.

Background: Inhaled corticosteroids reduce inflammation in asthma but chronic use may cause adverse effects. AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, has the potential of an improved risk-benefit profile. We investigated the safety and efficacy of AZD7594 in asthma. Read More

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http://dx.doi.org/10.1186/s12931-019-1000-7DOI Listing
February 2019

A unique presentation of superinfected pseudomyxoma peritonei secondary to a low-grade appendiceal mucinous neoplasm.

World J Surg Oncol 2019 Feb 18;17(1):34. Epub 2019 Feb 18.

Department of Surgical Oncology, Mount Sinai St. Luke's West Hospital, 425 W. 59th St., 7th Floor, New York, NY, 10019, USA.

Background: Pseudomyxoma peritonei (PMP) is an uncommon condition characterized by diffuse mucinous material in the abdomen and pelvis, generally arising from a perforated epithelial neoplasm. Typically, the disease presents as suspected acute appendicitis, ovarian mass, abdominal distension, or ventral hernia. Our case represents a very rare presentation of superinfected PMP. Read More

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http://dx.doi.org/10.1186/s12957-019-1578-8DOI Listing
February 2019

AAAAI/ACAAI subcutaneous immunotherapy (SCIT) surveillance study (2013-2017): fatalities, infections, delayed reactions and use of epinephrine auto-injectors.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Immunology, Allergy, and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; and Bernstein Clinical Research Center, Cincinnati, Ohio.

Background: SCIT is highly effective but safety risks exist.

Objective: The aims of this study were to: 1) identify clinical practices that could influence fatal and non-fatal systemic allergic reactions (SRs) to SCIT; and 2) identify SCIT-associated infections.

Methods: From 2008-2016, 27-51% of AAAAI/ACAAI members completed an annual survey of SCIT-related SRs of varying severity. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.058DOI Listing
February 2019

Do youth ask asthma providers the questions they want to ask?

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Cecil G. Sheps, Center for Health Services Research, University of North Carolina at Chapel Hill.

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https://linkinghub.elsevier.com/retrieve/pii/S22132198193016
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http://dx.doi.org/10.1016/j.jaip.2019.02.005DOI Listing
February 2019
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Point of care ultrasonography in the allergy and immunology clinic.

Ann Allergy Asthma Immunol 2019 Feb 15. Epub 2019 Feb 15.

Division of Clinical Immunology and Allergy, Department of Medicine, Western University, London, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.02.010DOI Listing
February 2019

House dust mite exposure attenuates influenza A infection in a mouse model of pulmonary allergic inflammation.

Microb Pathog 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology, Immunology and Molecular Genetics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. Electronic address:

Environmental allergens elicit complex immune responses in the lungs that can promote the development of asthma or exacerbate preexisting asthma in susceptible individuals. House dust mites are one of the most common indoor allergens and are a significant driver of allergic disease. Respiratory infections are known factors in acute exacerbations of asthma but the impact of allergen on the pathogen is not well understood. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.019DOI Listing
February 2019

Nasal IgE Production in Allergic Rhinitis: Impact of Rhinovirus Infection.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

Departments of Medicine, University of Virginia Health System, Charlottesville, VA, 22908.

Background: Rhinovirus (RV) infections exacerbate asthma in part by enhancing an allergic state and these exacerbations can be mitigated via administration of anti-IgE.

Objective: We investigated the presence of local IgE production in the nose of allergic and non-allergic subjects and assessed whether this was enhanced by RV.

Methods: Local production of specific IgE was determined by comparing ratios of specific to total IgE concentrations between nasal and serum samples. Read More

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http://dx.doi.org/10.1111/cea.13372DOI Listing
February 2019

Epithelial barrier repair and prevention of allergy.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, and.

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). This Review describes the formation of the skin barrier and analyzes the link between altered skin barrier formation and the pathogenesis of AD. Read More

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http://dx.doi.org/10.1172/JCI124608DOI Listing
February 2019

Non-malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta-analysis.

Am J Ind Med 2019 Feb 18. Epub 2019 Feb 18.

Respiratory Health Division, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Morgantown, West Virginia.

Background: Non-malignant respiratory disease (NMRD) cases have occurred among rubber manufacturing workers. We examined exposure to rubber manufacturing emissions as a risk factor for NMRD.

Methods: From a systematic literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (strong, intermediate, non-significant positive association, none) between exposure to rubber manufacturing emissions and NMRD-related morbidity and mortality, and conducted two meta-analyses. Read More

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http://dx.doi.org/10.1002/ajim.22959DOI Listing
February 2019

Urban-Rural Disparities in Chronic Obstructive Pulmonary Disease Management and Access in Uganda.

Chronic Obstr Pulm Dis 2019 Jan 4;6(1):17-28. Epub 2019 Jan 4.

Department of Medicine and Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Almost 90% of chronic obstructive pulmonary disease (COPD) deaths occur in low- and middle-income countries (LMICs), where there are large rural populations and access to health care for COPD is poor. The purpose of this study was to compare urban-rural provider experiences regarding systemic facilitators and barriers to COPD management and treatment access. We conducted a qualitative study using direct observations and in-depth semi-structured interviews with 16 and 10 health care providers in urban Kampala and rural Nakaseke, Uganda, respectively. Read More

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http://dx.doi.org/10.15326/jcopdf.6.1.2018.0143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373590PMC
January 2019

Acute Effects Using Light-Emitting Diode Therapy (LEDT) for Muscle Function during Isometric Exercise in Asthma Patients: A Pilot Study.

Biomed Res Int 2019 16;2019:7501870. Epub 2019 Jan 16.

Post-Graduate Program in Rehabilitation Sciences, Nove de Julho University (UNINOVE), São Paulo, SP, Brazil.

The aim of this study was to evaluate the effectiveness of acute application of LEDT in improving peripheral muscle performance during isometric exercise in patients with asthma. Eleven patients, with a mean age 38 ± 10, underwent a single LEDT and sham application in the femoral quadriceps' dominant member (cluster with 50 LED = 850 nm, 50 mW, 15 s; 37.5 J), 48 h apart in a randomized crossover design. Read More

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http://dx.doi.org/10.1155/2019/7501870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354134PMC
January 2019

European Respiratory Society International Congress, Paris, 2018: highlights from the Clinical Assembly.

ERJ Open Res 2019 Feb 11;5(1). Epub 2019 Feb 11.

Dept of Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.

This article contains highlights and a selection of the scientific advances from the European Respiratory Society's Clinical Assembly (Assembly 1 and its five respective groups) that were presented at the 2018 European Respiratory Society International Congress in Paris, France. The most relevant topics from each of the groups will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, and general practice and primary care. The newest research, actual data and highlight sessions will be discussed. Read More

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http://dx.doi.org/10.1183/23120541.00176-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368995PMC
February 2019

Vaccine containing G protein fragment and recombinant baculovirus expressing M2 protein induces protective immunity to respiratory syncytial virus.

Clin Exp Vaccine Res 2019 Jan 31;8(1):43-53. Epub 2019 Jan 31.

Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.

Purpose: Respiratory syncytial virus (RSV) can cause serious respiratory illnesses such as pneumonia, asthma, and bronchiolitis in infants and elderly or immunocompromised individuals. An RSV vaccine has yet to be developed; only prophylactic anti-RSV antibody is commercially available. So, we investigated whether our vaccine candidate is able to induce type 1 CD4 T helper (Th1), CD8 T-cell responses, and protective immunity without vaccine-enhanced disease (VED) against RSV. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.7774/cevr.2019.8
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http://dx.doi.org/10.7774/cevr.2019.8.1.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369125PMC
January 2019
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Two vs four puffs of albuterol: does dose change bronchodilator response?

J Asthma Allergy 2019 31;12:59-65. Epub 2019 Jan 31.

Department of Pediatric Pulmonary Medicine, Connecticut Children's Medical Center, Hartford, CT, USA,

Background: Reversible obstruction on spirometry may be used to diagnose asthma. As per 2005 American Thoracic Society (ATS) guidelines, our pulmonary center began using 360 µg (four puffs) of albuterol rather than 180 µg (two puffs) to determine reversibility on spirometry starting in 2009.

Hypothesis: We hypothesized that fewer patients would respond to two puffs of albuterol than four puffs during spirometric testing. Read More

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http://dx.doi.org/10.2147/JAA.S151531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362946PMC
January 2019

Real-world characteristics and disease burden of patients with asthma prior to treatment initiation with mepolizumab or omalizumab: a retrospective cohort database study.

J Asthma Allergy 2019 25;12:43-58. Epub 2019 Jan 25.

Respiratory, US Medical Affairs, GSK, La Jolla, CA, USA.

Purpose: Patients with severe asthma are eligible for asthma-specific biologics as add-on therapies, such as mepolizumab and omalizumab, when optimized controller therapies are unable to control their symptoms. However, few real-world data are available to describe the characteristics and associated economic burden of patients considered to be candidates for mepolizumab or omalizumab therapy.

Methods: This retrospective cohort study investigated patients with asthma (≥12 years of age) identified at the time of first mepolizumab or omalizumab administration (index date) in the MarketScan Commercial Database. Read More

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https://www.dovepress.com/real-world-characteristics-and-dis
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http://dx.doi.org/10.2147/JAA.S189676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354698PMC
January 2019
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