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    Innate lymphoid cells in asthma: cannabinoids on the balance.
    Allergy 2017 Feb 22. Epub 2017 Feb 22.
    Institute of Pharmacology, University of Bern, Bern, Switzerland.
    The network of cells and soluble mediators implicated in the pathogenesis of asthma and allergic disorders is complex. Deciphering details of the crosstalk between its components is essential for the identification of novel drug targets and for advances in patient management and precision medicine (1, 2). There is increasing evidence that innate lymphoid cells (ILCs) contribute to allergic responses (3). Read More

    Development of electrochemical biosensor for detection of pathogenic microorganism in Asian dust events.
    Chemosphere 2017 Feb 19;175:269-274. Epub 2017 Feb 19.
    Department of Chemical Engineering, Kwangwoon University, 20 Gwangun-Ro, Nowon-Gu, Seoul 01897, Republic of Korea. Electronic address:
    We developed a single-walled carbon nanotubes (SWCNTs)-based electrochemical biosensor for the detection of Bacillus subtilis, one of the microorganisms observed in Asian dust events, which causes respiratory diseases such as asthma and pneumonia. SWCNTs plays the role of a transducer in biological antigen/antibody reaction for the electrical signal while 1-pyrenebutanoic acid succinimidyl ester (1-PBSE) and ant-B. subtilis were performed as a chemical linker and an acceptor, respectively, for the adhesion of target microorganism in the developed biosensor. Read More

    Hospitalizations of Brazilian children under fiver years old: a systematic review.
    Epidemiol Serv Saude 2017 Jan-Mar;26(1):169-182
    Universidade Estadual da Paraíba, Mestranda do Programa de Pós-Graduação em Saúde Pública, Campina Grande-PB, Brasil.
    Objective:: to describe the causes of hospitalization of Brazilian children under five years old.

    Methods:: this is a systematic review of articles published from 2008 to 2015, searched in the databases Medline and LILACS; selected studies were critically analyzed through a validated instrument.

    Results:: eleven articles were included, four of them are ecological and seven are cross-sectional studies; respiratory diseases (n=5), parasitic infections (n=4) and perinatal diseases (n=2) were the main causes for hospitalizations in the reviwed articles; in the studies that analyzed the sensitive conditions, pneumonia (n=6), gastroenteritis (n=5), and asthma (n=5) were the mais causes pointed out. Read More

    Time trends in hospitalizations for Ambulatory Care Sensitive Conditions among children under five years old in Ceará, Brazil, 2000-2012.
    Epidemiol Serv Saude 2017 Jan-Mar;26(1):51-60
    Universidade Estadual do Ceará, Programa de Pós-Graduação em Saúde Coletiva, Fortaleza-CE, Brasil.
    Objective:: to analyze time trends and describe the causes of hospitalizations for Ambulatory Care Sensitive Conditions (ACSC) in children under five years old in Ceará, Brazil, 2000-2012.

    Methods:: this is an ecological time series study using data from the National Hospital Information System; trends were analyzed using Prais-Winsten regression.

    Results:: from 2000 and 2016 ACSC hospitalization rates fell from 32. Read More

    Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis.
    N Engl J Med 2017 Feb;376(8):717-728
    From the Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (A.B.), Dyax, Burlington (C. Soo, R.I., D.J.S., C.T., J.A.K., R.F., H.K., R.M., C. Stevens, J.C.B., Y.C., B.A.), and ICON Clinical Research, Marlborough (J.G.S.) - all in Massachusetts; the Division of Clinical Immunology and Allergy, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York (P.B.), and Winthrop University Hospital, Mineola (M.D.-L.) - both in New York; Triumpharma, Amman, Jordan (M.S., A.A.-G.); Asthma and Allergy Research Associates, Dallas (W.L.); the Division of Allergy and Immunology, Washington University School of Medicine, St. Louis (H.J.W.); Allergy and Asthma Medical Group, Walnut Creek (J.J.), and the Department of Rheumatology, Allergy, and Immunology, University of California, San Diego, San Diego (M.R.) - both in California; Baker Allergy, Asthma, and Dermatology, Lake Oswego, OR (J.B.); the Department of Internal Medicine-Allergy Section Cincinnati, University of Cincinnati College of Medicine, Cincinnati (J.A.B.); the Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa (R.L.); the Institute for Asthma and Allergy, Chevy Chase, MD (H.H.L.); the Department of Medicine and Pediatrics, Penn State Hershey Allergy, Asthma, and Immunology, Hershey, PA (T.C.); and the Department of Biomedical and Clinical Sciences, Luigi Sacco, University of Milan, and Luigi Sacco Hospital Milan, Milan (M.C.).
    Background Hereditary angioedema with C1 inhibitor deficiency is characterized by recurrent, unpredictable swelling episodes caused by uncontrolled plasma kallikrein generation and excessive bradykinin release resulting from cleavage of high-molecular-weight kininogen. Lanadelumab (DX-2930) is a new kallikrein inhibitor with the potential for prophylactic treatment of hereditary angioedema with C1 inhibitor deficiency. Methods We conducted a phase 1b, multicenter, double-blind, placebo-controlled, multiple-ascending-dose trial. Read More

    Let Them Breathe.
    NASN Sch Nurse 2017 Mar;32(2):91-93
    School Nurse, Camden City NJ School District, Camden City, NJ.
    Childhood asthma is caused by an interaction of genetic and modifiable environmental factors. Health inequities compound these environmental factors. As features of asthma are established during preschool years, these health inequities in urban children with asthma need to be addressed by preschool nurses. Read More

    Laryngeal sensitivity testing in youth with exercise-inducible laryngeal obstruction.
    Int J Rehabil Res 2017 Feb 20. Epub 2017 Feb 20.
    aDepartment for Otorhinolaryngology and Cervicofacial Surgery bUnit for Pulmonary Diseases, University Medical Centre of Ljubljana, University Children's Hospital cFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
    Exercise-inducible laryngeal obstruction (EILO) has been recognized as a not rare respiratory problem in youth practicing sports. The aim of the study was to test the mechanosensitivity of the larynx, and to identify the factors affecting it in a group of youth with proven EILO. Laryngeal sensory testing was performed in 54 adolescents and young adults with EILO. Read More

    Impact of nasal symptoms on the evaluation of asthma control.
    Medicine (Baltimore) 2017 Feb;96(8):e6147
    aDivision of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan bGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University cDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Keelung dDepartment of Thoracic Medicine eBiostatistical Center for Clinical Research, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
    The united airways concept suggests that patients with asthma typically exhibit parallel inflammation in the upper airway. The resulting nasal symptoms should reduce quality of life and substantially affect the evaluation of asthma control among these patients. This study aimed to assess the association of nasal symptoms with the evaluation of asthma control. Read More

    Pediatric asthma - moving ahead faster than ever.
    Curr Opin Allergy Clin Immunol 2017 Apr;17(2):96-98
    aDivision of Pediatric Allergy, Immunology and Pulmonary Medicine, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri bDivision of Pediatric Pulmonary Medicine, Breathing Institute, Children's Hospital Colorado; University of Colorado School of Medicine, Aurora, Colorado, USA.

    Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice.
    Sci Rep 2017 Feb 22;7:42655. Epub 2017 Feb 22.
    Department of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China.
    The small GTPase ras homolog enriched in brain (Rheb) is a downstream target of tuberous sclerosis complex 1/2 (TSC1/2) and an upstream activator of the mechanistic target of rapamycin complex 1 (mTORC1), the emerging essential modulator of M1/M2 balance in macrophages. However, the role and regulatory mechanisms of Rheb in macrophage polarization and allergic asthma are not known. In the present study, we utilized a mouse model with myeloid cell-specific deletion of the Rheb1 gene and an ovalbumin (OVA)-induced allergic asthma model to investigate the role of Rheb1 in allergic asthma and macrophage polarization. Read More

    Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.
    Mucosal Immunol 2017 Feb 22. Epub 2017 Feb 22.
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD). However, the mechanism by which the expression of these innate cytokines is regulated remains unclear. Intelectin (ITLN) is expressed in airway epithelial cells and promotes allergic airway inflammation. Read More

    Differences in outcomes in patients with stable coronary artery disease managed by cardiologists versus non-cardiologists: the international prospective CLARIFY registry.
    Pol Arch Med Wewn 2017 Jan 20. Epub 2017 Jan 20.
    INTRODUCTION    Clinical outcomes of patients with stable coronary artery disease (SCAD) may differ between those primarily managed by cardiologists versus non-cardiologists.  OBJECTIVES    Our main objective was to analyze the clinical outcomes of outpatients with SCAD in relation to the specialty of the managing physicians.  PATIENTS AND METHODS    We studied 32,468 outpatients with SCAD included in the CLARIFY registry, with up to 4 years follow-up data. Read More

    Microbiome, autoimmunity, allergy, and helminth infection: The importance of the pregnancy period.
    Am J Reprod Immunol 2017 Feb 21. Epub 2017 Feb 21.
    Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China.
    Pregnancy is a special physical period in reproductive age women, which has a beneficial influence on the course of certain autoimmune diseases. It has been recently suggested that the microbiome undergoes profound changes during pregnancy that are associated with host physiological and immunological adaptations. The maternal microbiome remodeling during pregnancy is an active response of the mother, possibly to alter immune system status and to facilitate metabolic and immunological adaptations, which are needed for a successful pregnancy. Read More

    Galactose-α-1,3-Galactose: Atypical Food Allergen or Model IgE Hypersensitivity?
    Curr Allergy Asthma Rep 2017 Jan;17(1)
    Division of Allergy, Asthma, and Immunology, University of Virginia Health System, PO Box 801355, Charlottesville, VA, 22908, USA.
    Purpose Of Review: Galactose-α-1,3-galactose (α-gal) is a carbohydrate allergen with several unique characteristics. In this article, we discuss some recent advances in our understanding of the 'alpha-gal syndrome,' highlight data supporting the role of ticks in pathogenesis, and speculate on immune mechanisms that lead to sensitization.

    Recent Findings: First described as the target of IgE in individuals suffering immediate hypersensitivity reactions to the novel anti-EGF monoclonal antibody cetuximab, it is now clear that α-gal sensitization is associated with mammalian meat allergy as well as reactions to other mammalian products. Read More

    Pediatric asthma severity score is associated with critical care interventions.
    World J Clin Pediatr 2017 Feb 8;6(1):34-39. Epub 2017 Feb 8.
    Danielle K Maue, Courtney M Rowan, Department of Pediatric Critical Care, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
    Aim: To determine if a standardized asthma severity scoring system (PASS) was associated with the time spent on continuous albuterol and length of stay in the pediatric intensive care unit (PICU).

    Methods: This is a single center, retrospective chart review study at a major children's hospital in an urban location. To qualify for this study, participants must have been admitted to the PICU with a diagnosis of status asthmaticus. Read More

    Airway gene expression of IL-1 pathway mediators predicts exacerbation risk in obstructive airway disease.
    Int J Chron Obstruct Pulmon Dis 2017 8;12:541-550. Epub 2017 Feb 8.
    Faculty of Health and Medicine, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton, NSW, Australia.
    Background: Exacerbations of asthma and COPD are a major cause of morbidity and mortality and are responsible for significant health care costs. This study further investigates interleukin (IL)-1 pathway activation and its relationship with exacerbations of asthma and COPD.

    Methods: In this prospective cohort study, 95 participants with stable asthma (n=35) or COPD (n=60) were recruited and exacerbations recorded over the following 12 months. Read More

    Asthma-COPD overlap syndrome in the US: a prospective population-based analysis of patient-reported outcomes and health care utilization.
    Int J Chron Obstruct Pulmon Dis 2017 3;12:517-527. Epub 2017 Feb 3.
    Department of Medicine, Yale School of Medicine, New Haven.
    Background: Prior work suggests that asthma-COPD overlap syndrome (ACOS) has a greater health burden than asthma alone or COPD alone. In the current study, we have further evaluated the health burden of ACOS in a nationally representative sample of the US population, focusing on patient-reported outcomes and health care utilization and on comparisons with asthma alone and COPD alone. Patient-reported outcomes are especially meaningful, as these include functional activities that are highly valued by patients and are the basis for patient-centered care. Read More

    Effectiveness of Specific Sublingual Immunotherapy in Korean Patients with Atopic Dermatitis.
    Ann Dermatol 2017 Feb 3;29(1):1-5. Epub 2017 Feb 3.
    Department of Dermatology, Pusan National University School of Medicine, Busan, Korea.; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
    Background: Sublingual immunotherapy (SLIT) with house dust mites (HDM) preparation has recently been proven to be beneficial for treating allergic rhinitis and asthma. However, there has been no report regarding the efficacy and safety of SLIT in Korean patients with atopic dermatitis (AD).

    Objective: We intended to investigate the efficacy and safety of SLIT in Korean patients with AD. Read More

    The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo.
    Sci Signal 2017 Feb 21;10(467). Epub 2017 Feb 21.
    Department of Immunology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
    Cyanidin, a key flavonoid that is present in red berries and other fruits, attenuates the development of several diseases, including asthma, diabetes, atherosclerosis, and cancer, through its anti-inflammatory effects. We investigated the molecular basis of cyanidin action. Through a structure-based search for small molecules that inhibit signaling by the proinflammatory cytokine interleukin-17A (IL-17A), we found that cyanidin specifically recognizes an IL-17A binding site in the IL-17A receptor subunit (IL-17RA) and inhibits the IL-17A/IL-17RA interaction. Read More

    Development and Testing of the Pediatric Respiratory Illness Measurement System (PRIMES) Quality Indicators.
    Hosp Pediatr 2017 Feb 21. Epub 2017 Feb 21.
    Kaiser Permanente Center for Effectiveness and Safety Research, Pasadena, California.
    Objectives: To develop and test quality indicators for assessing care in pediatric hospital settings for common respiratory illnesses.

    Patients: A sample of 2796 children discharged from the emergency department or inpatient setting at 1 of the 3 participating hospitals with a primary diagnosis of asthma, bronchiolitis, croup, or community-acquired pneumonia (CAP) between January 1, 2010, and December 31, 2011.

    Setting: Three tertiary care children's hospitals in the United States. Read More

    Interleukin 32, Inflammation and Cancer.
    Pharmacol Ther 2017 Feb 13. Epub 2017 Feb 13.
    College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungduk-gu, Cheongju, Chungbuk, 361-951, Republic of Korea. Electronic address:
    Interleukin-32 (IL-32) is a novel cytokine involved in inflammation and cancer development. IL-32 gene consists of eight small exons, and IL-32 mRNA has nine alternative spliced isoforms, and was thought to be secreted because it contains an internal signal sequence and lacks a transmembrane region. IL-32 is initially expressed selectively in activated T cells by mitogen and activated NK cells and their expression is strongly augmented by microbes, mitogens, and other cytokines. Read More

    Mitogen-Activated Protein Kinases as Therapeutic Targets for Asthma.
    Pharmacol Ther 2017 Feb 13. Epub 2017 Feb 13.
    Molecular Immunology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Boston, MA, USA. Electronic address:
    Corticosteroid-resistant asthmatics, although comprising only a portion of the asthma population, account for most of the morbidity, mortality and economic burden associated with asthma. Moreover, corticosteroids are not effective inhibitors of airway remodeling changes, and their long-term use is associated with debilitating systemic side effects. Therefore, potent and safe novel therapeutic alternatives, targeting basic pathophysiological mechanisms responsible for the severe asthmatic phenotype are urgently needed. Read More

    Effect of Bronchial Asthama on Porphyrin Levels in Patients of Atopic Dermatitis - a Spectrophotometric Study.
    Indian J Dermatol Venereol Leprol 1980 Sep-Oct;46(5):263-266
    A quantitative assay of porphyrins in blood, urine and stool of 30 patients with atopic dermatitis, 17 without and 13 with bronchial asthma was done. Rimington's technique for the estimation of porphyrins was employed. No statistically significant difference in porphyrin levels was observed between patients without and with bronchial asthma. Read More

    Dietary total antioxidant capacity in early school age and subsequent allergic disease.
    Clin Exp Allergy 2017 Feb 21. Epub 2017 Feb 21.
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Background: Dietary antioxidant intake has been hypothesized to influence the development of allergic diseases, however, few prospective studies have investigated this association.

    Objective: Our aim was to study the association between total antioxidant capacity (TAC) of the diet at age 8 years and the subsequent development of asthma, rhinitis and sensitization to inhalant allergens between 8 and 16 years, and to assess potential effect modification by known risk factors.

    Methods: 2359 children from the Swedish birth cohort BAMSE were included. Read More

    Elevated expression of placental growth factor is associated with airway-wall vascular remodelling and thickening in smokers with asthma.
    Sci Rep 2017 Feb 21;7:43017. Epub 2017 Feb 21.
    Institute of Respiratory Diseases, Department of Respiratory, The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
    The increased expression of placental growth factor (PlGF) in chronic obstructive pulmonary disease and allergy-related asthma suggests its role in the pathogenesis of these diseases. In asthmatic smokers, airway remodelling is accompanied by an accelerated decline in lung function. However, whether PlGF contributes to the persistent airflow obstruction and vascular remodelling typically seen in asthmatic smokers is unknown. Read More

    Asthma control in adult patients treated with a combination of inhaled corticosteroids and long-acting beta-2 agonists: a prospective observational study.
    Pol Arch Med Wewn 2017 Jan 18. Epub 2017 Jan 18.
    INTRODUCTION    Asthma is a highly prevalent disease that often requires maintenance therapy. Combined inhaled corticosteroid and long-acting beta-2 agonist (ICS/LABA) inhalers are one of the available maintenance treatment options.  OBJECTIVES    This prospective observational study aimed to assess asthma control in patients treated with ICS/LABA inhalers and to identify factors related to controlled asthma. Read More

    Burden of fungal infections in Algeria.
    Eur J Clin Microbiol Infect Dis 2017 Feb 21. Epub 2017 Feb 21.
    The University of Manchester, National Aspergillosis Centre, University Hospital of South Manchester and Manchester Academic Health Science Centre, Manchester, UK.
    We report for the first time in Algeria and provide burden estimates. We searched for existing data and estimated the incidence and prevalence of fungal diseases based on the population at risk and available epidemiological data. Demographic data were derived from the National Office of Statistics (Office National des Statistiques: ONS), World Health Organization (WHO), The Joint Nations Programme on HIV/AIDS (UNAIDS) and national published reports. Read More

    Serious fungal infections in the Philippines.
    Eur J Clin Microbiol Infect Dis 2017 Feb 21. Epub 2017 Feb 21.
    Education and Research Center, University Hospital of South Manchester, Southmoor Road, Manchester, M23 9LT, UK.
    The Philippines is a low middle-income, tropical country in Southeast Asia. Infectious diseases remain the main causes of morbidity, including tuberculosis. AIDS/HIV prevalence is still low at <1%, but is rapidly increasing. Read More

    Work stress, family stress and asthma: a cross-sectional study among women in China.
    Int Arch Occup Environ Health 2017 Feb 20. Epub 2017 Feb 20.
    Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Düsseldorf, Germany.
    Purpose: Research addressing links of work stress or family stress with asthma is constrained by (1) inconsistent evidence, (2) failure to consider the combined exposure to work stress and family stress, and (3) its primary focus on Western study populations. We aimed to address these knowledge gaps.

    Methods: We used cross-sectional data collected in 2015 among 7816 women from five professional groups in five Chinese cities. Read More

    Exhaled and nasal nitric oxide in relation to lung function, blood cell counts and disease characteristics in cystic fibrosis.
    J Breath Res 2017 Feb 21. Epub 2017 Feb 21.
    Department of Medical Sciences,Uppsala University, Uppsala University, Akademiska sjukhuset, S-751 85 , Uppsala, Uppsala,SWEDEN.
    Background: Patients with CF have similar or lower exhaled nitric oxide (FeNO) and lower nasal nitric oxide (nNO) levels than controls. There are divergent results on alveolar NO (CalvNO) concentrations in relation to CF. There are inconsistent results on correlation between different nitric oxide parameters and lung function and inflammation in CF. Read More

    Features of a Mobile Support App for Patients With Chronic Obstructive Pulmonary Disease: Literature Review and Current Applications.
    JMIR Mhealth Uhealth 2017 Feb 20;5(2):e17. Epub 2017 Feb 20.
    Pulmonary Clinic, George Papanikolaou General Hospital, Thessaloniki, Greece.
    Background: Chronic obstructive pulmonary disease (COPD) is a serious long-term lung disease in which the airflow from the lungs is progressively reduced. By 2030, COPD will become the third cause of mortality and seventh cause of morbidity worldwide. With advances in technology and mobile communications, significant progress in the mobile health (mHealth) sector has been recently observed. Read More

    Does neighborhood social and environmental context impact race/ethnic disparities in childhood asthma?
    Health Place 2017 Feb 17;44:86-93. Epub 2017 Feb 17.
    Baylor College of Medicine and Texas Children's Hospital, 6621 Fannin Street, Houston, TX 77030, USA. Electronic address:
    Utilizing over 140,000 geocoded medical records for a diverse sample of children ages 2-12 living in Houston, Texas, we examine whether a comprehensive set of neighborhood social and environmental characteristics explain racial and ethnic disparities in childhood asthma. Adjusting for all individual risk factors, as well as neighborhood concentrated disadvantage, particulate matter, ozone concentration, and race/ethnic composition, reduced but did not fully attenuate the higher odds of asthma diagnosis among black (OR=2.59, 95% CI=2. Read More

    Clarithromycin attenuates IL-13-induced periostin production in human lung fibroblasts.
    Respir Res 2017 Feb 20;18(1):37. Epub 2017 Feb 20.
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
    Background: Periostin is a biomarker indicating the presence of type 2 inflammation and submucosal fibrosis; serum periostin levels have been associated with asthma severity. Macrolides have immunomodulatory effects and are considered a potential therapy for patients with severe asthma. Therefore, we investigated whether macrolides can also modulate pulmonary periostin production. Read More

    Women's experiences of personalised support for asthma care during pregnancy: A systematic review of the literature.
    BMC Pregnancy Childbirth 2017 Feb 20;17(1):69. Epub 2017 Feb 20.
    Women's Health Directorate, Royal Devon and Exeter Hospital NHS Trust, Barrack RD., Exeter, EX25DW, UK.
    Background: Asthma and pregnancy are both sources of anxiety for women. Although there has been a focus on physiological management of asthma and pregnancy, there has been little research on the impact that personalised support can have on asthma care during pregnancy. This systematic review and narrative synthesis of the literature set out to answer the question 'What are women's experiences of asthma care, its management and education, during pregnancy?'

    Methods: This systematic review was carried out using accepted methodology from the York Centre for Reviews and Dissemination. Read More

    Phytochemical screening and evaluation of in vitro antioxidant and antimicrobial activities of the indigenous medicinal plant Albizia odoratissima.
    Pharm Biol 2017 Dec;55(1):1155-1161
    a Department of Bio-Technology , Center for Bio-Technology, Institute of Science & Technology, Jawaharlal Nehru Technological University Hyderabad , Hyderabad , Telangana , India.
    Context: Albizia odoratissima (L. f.) Benth has been used in Indian folk medicine to treat numerous inflammatory pathologies, such as leprosy, ulcers, burns and asthma. Read More

    No blank slates: Pre-existing schemas about pharmaceuticals predict memory for side effects.
    Psychol Health 2017 Apr;32(4):402-421
    a Research Department of Practice and Policy , University College London School of Pharmacy , London , UK.
    Objectives: Attribution of symptoms as medication side effects is informed by pre-existing beliefs about medicines and perceptions of personal sensitivity to their effects (pharmaceutical schemas). We tested whether (1) pharmaceutical schemas were associated with memory (recall/recognition) for side effect information (2) memory explained the attribution of a common unrelated symptom as a side effect.

    Design: In this analogue study participants saw the patient leaflet of a fictitious asthma drug listing eight side effects. Read More

    [Function and modulation of type Ⅱ innate lymphoid cells and their role in chronic upper airway inflammatory diseases].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Feb;52(2):130-135
    Department of Otorhinolaryngology of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
    Type Ⅱ innate lymphoid cells (ILC2) is a family of innate immune lymphocytes, which provide effective immune responses to cytokines. ILC2 are regulated by the nuclear transcription factor ROR alpha and GATA3, secreting cytokines IL-5 and IL-13, etc. Animal models have shown that ILC2 are involved in allergic diseases, such as asthma and atopic dermatitis, and also play a very important role in the metabolic balance. Read More

    [The value of sinonasal CT scan in diagnosing of eosinophilic chronic rhinosinusitis with nasal polyps].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Feb;52(2):93-98
    Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otorhinolaryngology, Beijing 100005, China; Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
    Objective: To compare the value of sinonasal CT scan with other clinical parameters in the pre-diagnosis of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP). Methods: From January to May of 2016, One hundred and fifty consecutive CRSwNP patients (90 eCRSwNP and 60 non-eosinophilic CRSwNP) undergoing endoscopic functional sinus surgery in Beijing Tongren Hospital were recruited in this study. Preoperative CT scan, skin prick test (SPT) and oral fractional exhaled nitric oxide (FeNO) measurements were performed in each patient and full blood count with differential analysis was performed within 1 week before surgery. Read More

    Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis.
    Int Arch Allergy Immunol 2017 Feb 21;172(1):11-19. Epub 2017 Feb 21.
    Departments of Dermatology, Venereology, and Allergology, Medical University of Gdansk, Gdansk, Poland.
    Background: It is assumed that beside alterations in the filaggrin gene (FLG), disturbances within genes encoding other cornified envelope proteins are also involved in atopic dermatitis (AD). To identify new potential markers of AD, we studied the polymorphisms of genes encoding repetin (RPTN), cornulin (CRNN), and their expression in the skin of AD patients.

    Methods: Polymorphisms in CRNN (rs941934), RPTN (rs284544, rs28441202, rs3001978, and rs12117644), and FLG mutations (R2447X, S3247X) were analyzed by TaqMan genotyping assay and by PCR-RFLP in the blood samples of 159 AD patients and 108 healthy subjects. Read More

    Synergistic Actions of Histamine-Releasing Factor and Histamine Releasing Factor-Reactive IgE in Chronic Urticaria.
    Int Arch Allergy Immunol 2017 Feb 21;172(1):27-32. Epub 2017 Feb 21.
    The etiology of chronic urticaria (CU) remains elusive. Histamine-releasing factor (HRF) is reported to have a proinflammatory role in asthma and immediate hypersensitivity of the skin. The aim of this study was to examine the role of HRF in the pathogenesis of CU. Read More

    Risk factors hindering asthma symptoms control in Saudi children and adolescents.
    Pediatr Int 2017 Feb 20. Epub 2017 Feb 20.
    Immunology Research laboratory and Asthma Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Background: Maintaining well control of asthma symptoms can help preventing exacerbations and its associated complications. The Asthma Control Test (ACT) can rapidly assess the effectiveness of asthma management plan and therapy.

    Objective: To identify risk factors associated with uncontrolled asthma symptoms in young Saudi asthmatics (3-17 years-old). Read More

    Bee Venom Phospholipase A2 Ameliorates House Dust Mite Extract Induced Atopic Dermatitis Like Skin Lesions in Mice.
    Toxins (Basel) 2017 Feb 18;9(2). Epub 2017 Feb 18.
    Department of Science in Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea.
    Atopic dermatitis (AD) is a biphasic inflammatory skin disease that is provoked by epidermal barrier defects, immune dysregulation, and increased skin infections. Previously, we have demonstrated that bvPLA2 evoked immune tolerance by inducing regulatory T cells (Treg), and thus alleviated Th2 dominant allergic asthma in mice. Here, we would like to determine whether treatment with bvPLA2 exacerbates the AD-like allergic inflammations induced by house dust mite extract (DFE) in a murine model. Read More

    Spontaneous pneumomediastinum in a healthy young female: A case report and literature review.
    Respir Med Case Rep 2017 6;20:129-132. Epub 2017 Feb 6.
    Department of Internal Medicine, Seton Hall University School of Medicine, Saint Francis Medical Center, Trenton, NJ, USA.
    Spontaneous pneumomediastinum (SPM) is an uncommon finding in young adults presenting usually without any comorbidities or an underlying pathology. It is most commonly due to alveolar rupture in the setting of an inciting event such an underlying asthma, barotrauma, valsalva maneuver, or esophageal rupture. Individuals can have varying presentations, from chest pain, dyspnea and dysphagia, to anxiety, weakness, or facial and neck swelling. Read More

    Visual analogue scales (VAS): Measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care: Position Paper of the German Society of Allergology (AeDA) and the German Society of Allergy and Clinical Immunology (DGAKI), ENT Section, in collaboration with the working group on Clinical Immunology, Allergology and Environmental Medicine of the German Society of Otorhinolaryngology, Head and Neck Surgery (DGHNOKHC).
    Allergo J Int 2017 19;26(1):16-24. Epub 2017 Jan 19.
    Center for Rhinology and Allergology, An den Quellen 10, 65183 Wiesbaden, Germany ; 0000 0001 2190 4373grid.7700.0Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty Mannheim, Universitätsmedizin Mannheim, Heidelberg University, Mannheim, Germany.
    Backround: Visual analogue scales (VAS) are psychometric measuring instruments designed to document the characteristics of disease-related symptom severity in individual patients and use this to achieve a rapid (statistically measurable and reproducible) classification of symptom severity and disease control. VAS can also be used in routine patient history taking and to monitor the course of a chronic disease such as allergic rhinitis (AR). More specifically, the VAS has been used to assess effectiveness of AR therapy in real life, both in intermittent and persistent disease. Read More

    Pharmacological evaluation of Apium leptophyllum (Pers.) on bronchial asthma.
    J Pharm Bioallied Sci 2016 Oct-Dec;8(4):341-345
    Department of Pharmaceutical Chemistry, Sri Sivani College of Pharmacy, Srikakulam, Andhra Pradesh, India.
    Objective: The present study was to investigate the antiasthmatic potential from the flavonoid fraction of Apium leptophyllum fruit (FFALF) to validate its traditional claim.

    Materials And Methods: The antiasthmatic activity of FFALF was evaluated by histamine or acetylcholine-induced bronchospasm model in guinea pigs, compound 48/80 induced mast cell degranulation in albino rats and histamine-induced tracheal contraction in guinea pig. The preconvulsion dyspnea time at 0(th) and 7(th) day at the dose of 100 and 200 mg/kg in guinea pig's bronchospasm model, the percentage of granulated and degranulated mast cell at the dose of 500, 750, and 1000 μg/ml in rats and tracheal contraction at the dose of 500, 750, and 1000 μg/ml in guinea pig were measured and compared with respective control groups. Read More

    Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei.
    Sci Rep 2017 Feb 20;7:42791. Epub 2017 Feb 20.
    Centre for Research and Development of Medical Diagnostic Laboratories, Khon Kaen University, Khon Kaen, Thailand.
    Melioidosis, caused by Burkholderia pseudomallei, is endemic in northeastern Thailand and Northern Australia. Severe septicemic melioidosis is associated with high levels of pro-inflammatory cytokines and is correlated with poor clinical outcomes. IL-10 is an immunoregulatory cytokine, which in other infections can control the expression of pro-inflammatory cytokines, but its role in melioidosis has not been addressed. Read More

    Clinical Signs, Staphylococcus and Atopic Eczema-Related Seromarkers.
    Molecules 2017 Feb 14;22(2). Epub 2017 Feb 14.
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.
    Childhood eczema or atopic dermatitis (AD) is a distressing disease associated with pruritus, sleep disturbance, impaired quality of life and Staphylococcus aureus isolation. The pathophysiology of AD is complex and various seromarkers of immunity are involved. We investigated if anti-staphylococcal enterotoxin IgE (anti-SE), selected seromarkers of T regulatory (Treg), T helper (Th) and antigen-presenting cells (APC) are associated with clinical signs of disease severity and quality of life. Read More

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