179,535 results match your criteria Asthma


The Lowering of Bilirubin Levels in Full-Term Newborns by the Effect of Combined Massage Therapy and Phototherapy Practice.

Am J Perinatol 2019 Apr 18. Epub 2019 Apr 18.

Faculty of Medicine, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective:  Various therapeutic treatments have been prescribed for decreasing the bilirubin level. Massage therapy is one of the neonate treatments for jaundice. The aim of this study is to investigate the effects of combined massage therapy and phototherapy on neonatal jaundice. Read More

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http://dx.doi.org/10.1055/s-0039-1685493DOI Listing

Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey.

Int Arch Allergy Immunol 2019 Apr 18:1-8. Epub 2019 Apr 18.

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Background: Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known.

Objective: To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well as drug and healthcare costs.

Methods: Nationwide Allergy Barometer Survey was carried out in the Finnish pharmacies during 1 week in September 2016. Read More

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http://dx.doi.org/10.1159/000498861DOI Listing

House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice.

Int Arch Allergy Immunol 2019 Apr 18:1-9. Epub 2019 Apr 18.

Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, USA,

Aim: Asthma appears to be a common comorbid condition in children with sickle cell disease (SCD), and such individuals may be at a higher risk for increased morbidity and mortality. However, several reports have indicated that asthma severity is not particularly high in those with SCD, and airway hyperreactivity and wheeze may be independently associated with SCD. In SCD mice, exacerbated allergic airway disease (AAD) has been observed in response to the model antigen ovalbumin (OVA). Read More

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https://www.karger.com/Article/FullText/499043
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http://dx.doi.org/10.1159/000499043DOI Listing
April 2019
1 Read

Mapping inequality: Childhood asthma and environmental injustice, a case study of St. Louis, Missouri.

Authors:
Kelly M Harris

Soc Sci Med 2019 Mar 27;230:91-110. Epub 2019 Mar 27.

Washington University in St. Louis, One Brookings Drive, Campus Box 1183, Saint Louis, MO 63130, USA. Electronic address:

As a geographic continuum of poverty and affluence has emerged, so too has a geographic continuum of good and poor health. Asthma is currently one of the most prevalent chronic childhood diseases. Over the past three decades, the greatest increases in asthma rates have been in urban areas and have disproportionately affected youth in poverty and those in racial and ethnic minority groups. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.03.040DOI Listing

IL-17-high asthma with features of a psoriasis immunophenotype.

J Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Respiratory, Inflammation, Autoimmunity IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Background: The role of interleukin-17 immunity is well established in inflammatory diseases like psoriasis and inflammatory bowel disease but not in asthma where further study is required.

Objective: To undertake a deep-phenotyping study of asthmatics with up-regulated interleukin-17 immunity.

Methods: Whole genome transcriptomic analysis was performed using epithelial brushings, bronchial biopsies (91 asthmatics patients and 46 healthy controls) and whole blood samples (n=498) from the U-BIOPRED cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193048
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http://dx.doi.org/10.1016/j.jaci.2019.03.027DOI Listing
April 2019
1 Read

Cadmium exposure upregulates SNAIL through miR-30 repression in human lung epithelial cells.

Toxicol Appl Pharmacol 2019 Apr 15. Epub 2019 Apr 15.

Department of Environmental Medicine, New York University School of Medicine, New York, NY 10010, USA. Electronic address:

Cadmium (Cd) is a known human lung carcinogen. In addition, Cd exposure is associated with several lung diseases including emphysema, chronic obstructive pulmonary disease (COPD), asthma and fibrosis. Although earlier studies have identified several processes dysregulated by Cd exposure, the underlying mechanisms remain unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X193013
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http://dx.doi.org/10.1016/j.taap.2019.04.011DOI Listing
April 2019
1 Read

Quality Improvement Opportunities Identified Through Case Review of Pregnancy-Related Deaths From Cardiovascular Disease.

J Obstet Gynecol Neonatal Nurs 2019 Apr 15. Epub 2019 Apr 15.

Objective: To analyze quality improvement opportunities (QIOs) identified through review of cases of maternal death from cardiovascular disease (CVD) by the California Pregnancy-Associated Mortality Review committee.

Design: Qualitative descriptive design using thematic analysis.

Sample: A total of 269 QIOs identified from 87 pregnancy-related deaths from CVD in California from 2002 to 2007. Read More

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http://dx.doi.org/10.1016/j.jogn.2019.03.001DOI Listing

Factors associated with uncontrolled asthma in adult asthmatics in Kinshasa, Democratic Republic of Congo.

PLoS One 2019 18;14(4):e0215530. Epub 2019 Apr 18.

Department of Epidemiology and Biostatistics, School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

Background: The ultimate goal of asthma treatment is long-term control. Uncontrolled asthma is a major public health problem worldwide, but there is a lack of data on asthma control and its causes in the Democratic Republic of Congo (DRC).

Objective: To determine the socio-demographic, environmental, clinical, and biological factors and comorbidities associated with uncontrolled adult asthma in Kinshasa, DRC. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215530PLOS

Otitis Media in Childhood and Disease in Adulthood: A 40-Year Follow-Up Study.

Ear Hear 2019 Apr 16. Epub 2019 Apr 16.

Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.

Objectives: The pathogenesis of chronic suppurative otitis media (CSOM) includes complex interactions between microbial, immunologic, and genetic factors. To our knowledge, no study has focused on the association between childhood otitis media, immune regulation, inflammatory conditions, and chronic disease in adulthood. The present study aims to assess whether CSOM in childhood predicts immune-related inflammatory disorders or cardiovascular disease in adulthood. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000729DOI Listing
April 2019
1 Read

Mediterranean diet during pregnancy and childhood for asthma in children: A systematic review and meta-analysis of observational studies.

Pediatr Pulmonol 2019 Apr 17. Epub 2019 Apr 17.

Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To evaluate the relationship between high adherence to the Mediterranean diet in pregnancy and childhood and the risk of asthma and wheeze in children.

Methods: We conducted searches of PubMed, EMBASE, and Cochrane Central Register of Controlled Trials from inception to 30 October 2018. Observational studies providing risk estimates and corresponding confidence intervals on the association of high adherence to the Mediterranean diet in pregnancy or childhood and the risk of asthma or wheeze in childhood were included. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24338
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http://dx.doi.org/10.1002/ppul.24338DOI Listing
April 2019
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The correlation of adenosine challenge test results with subsequent clinical course among young children with suspected asthma: a retrospective cohort study.

Pediatr Pulmonol 2019 Apr 17. Epub 2019 Apr 17.

Pediatric Pulmonary Unit, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem, Israel.

Aim: Our aim was to evaluate the correlation of Adenosine monophosphate challenge test (AMP-PCW) results with the patients' subsequent clinical course.

Methods: We performed a 6-year retrospective cohort study of young children with suspected asthma who underwent AMP-PCW test.

Results: Fifty four children were included in the study (median age, 50. Read More

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http://dx.doi.org/10.1002/ppul.24337DOI Listing

The Economic Burden of Asthma in Greece: A Cross-Sectional Study.

Appl Health Econ Health Policy 2019 Apr 17. Epub 2019 Apr 17.

EVROSTON LP, Chatzigianni Mexi 5, 115 28, Athens, Greece.

Background: The high prevalence rates of asthma worldwide and the chronic nature of the disease make asthma a major cause of morbidity, imposing a significant socio-economic burden in many countries. Specifically in Greece, the self-reported prevalence of asthma reached 9% in 2017.

Objectives: The objective of this study was to estimate the total management cost of asthma in Greece and its potential determinants. Read More

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http://link.springer.com/10.1007/s40258-019-00469-4
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http://dx.doi.org/10.1007/s40258-019-00469-4DOI Listing
April 2019
1 Read

The message from the matrix-should we listen more closely?

J Thorac Dis 2019 Mar;11(Suppl 3):S230-S233

Nordic Bioscience A/S, Herlev Hovedgade, Herlev, Denmark.

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http://dx.doi.org/10.21037/jtd.2019.01.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424747PMC

Does transbronchial lung cryobiopsy give useful information in asthmatic patients?

Multidiscip Respir Med 2019 8;14:12. Epub 2019 Apr 8.

Department of Thoracic Diseases, "GB. Morgagni" Hospital, Forlì, Italy.

Introduction: Lung biopsy in asthmatic patients is justified in case of atypical presentations of asthma, when other differential diagnoses, such as hypersensitivity pneumonitis or eosinophilic granulomatosis with polyangiitis, could be possible or for research purposes.

Aim: We aim to describe the utility and the safety of TBLC (transbronchial lung cryobiopsy) in asthmatic patients, providing data on the pathological changes occurring in the airways and in the lung parenchyma.

Methods: We reviewed asthmatic patients that underwent TBLC, that eventually had only a final diagnosis of asthma. Read More

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http://dx.doi.org/10.1186/s40248-019-0176-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452509PMC

Angina and chronic obstructive pulmonary disease: facing the perfect storm.

Eur Heart J Suppl 2019 Apr 10;21(Suppl C):C17-C20. Epub 2019 Apr 10.

Cardiovascular Centre of Ferrara University, Ferrara, Italy.

The association of chronic obstructive pulmonary disease (COPD) and ischaemic heart disease (IHD) is challenging both in terms of prognosis and of pharmacological treatment. An 83-year-old Caucasian male patient has chronic kidney disease, COPD, previous myocardial infarction, coronary artery bypass graft with left internal mammary artery (LIMA) on left anterior descending (LAD), saphenous vein graft (SVG) on obtuse marginal (OM)1 and on right coronary artery, and percutaneous coronary intervention (PCI) on LAD (occlusion of LIMA) and on SVG for OM1 (SVG critical stenosis). Recently, the patient complained worsening angina [Canadian Cardiovascular Society (CCS) III] and had residual ischaemia in the anterior wall after an unsuccessful attempt of PCI was performed on LAD for in-stent occlusion due to restenosis. Read More

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http://dx.doi.org/10.1093/eurheartj/suz042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456878PMC

Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.

Sci Rep 2019 Apr 17;9(1):6206. Epub 2019 Apr 17.

Division of Allergy & Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full thickness human donor esophagi to create and validate the ex vivo function of mucosa and smooth muscle (n = 25). Explanted tissue was tested for contractile responses to carbachol and histamine. Read More

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http://dx.doi.org/10.1038/s41598-019-41147-8DOI Listing

Chronic pesticide mixture exposure including paraquat and respiratory outcomes among Colombian farmers.

Ind Health 2019 Apr 18. Epub 2019 Apr 18.

Public Health Department, Medicine and Health Sciences School, Universidad del Rosario, Colombia.

This study explored the potential association between chronic exposure to pesticide mixtures including paraquat and respiratory outcomes among Colombian farmers. Sociodemographic and occupational data, respiratory symptoms and spirometric data were collected. Paraquat in spot urine samples were quantified with solid-phase extraction high-performance liquid chromatography. Read More

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http://dx.doi.org/10.2486/indhealth.2018-0111DOI Listing

The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

National Jewish Health, Denver, Colorado, USA.

Bacterial permeability family member A1 (BPIFA1), also known as short palate, lung, and nasal epithelium clone 1 (SPLUNC1), is a protein involved in the antiinflammatory response. The goal of this study was to determine whether BPIFA1 expression in asthmatic airways is regulated by genetic variations, altering epithelial responses to type 2 cytokines (e.g. Read More

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https://insight.jci.org/articles/view/127237
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http://dx.doi.org/10.1172/jci.insight.127237DOI Listing
April 2019
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Endobronchial valves for severe emphysema.

Eur Respir Rev 2019 Jun 17;28(152). Epub 2019 Apr 17.

Dept of Pulmonary diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

The results of the randomised controlled trials investigating the bronchoscopic lung volume reduction treatment using endobronchial valves (EBV) are promising, and have led to their inclusion in treatment guidelines, US Food and Drug Administration approval and inclusion in routine care in an increasing number of countries. The one-way valve treatment has advanced and is now a regular treatment option. However, this new phase will lead to new challenges in terms of implementation. Read More

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http://dx.doi.org/10.1183/16000617.0121-2018DOI Listing

Dismantling the pathophysiology of asthma using imaging.

Eur Respir Rev 2019 Jun 17;28(152). Epub 2019 Apr 17.

Woolcock Institute of Medical Research and Northern Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Asthma remains an important disease worldwide, causing high burden to patients and healthcare systems and presenting a need for better management and ultimately prevention and cure. Asthma is a very heterogeneous condition, with many different pathophysiological processes. Better measurement of those pathophysiological processes are needed to better phenotype disease, and to go beyond the current, highly limited measurements that are currently used: spirometry and symptoms. Read More

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http://err.ersjournals.com/lookup/doi/10.1183/16000617.0111-
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http://dx.doi.org/10.1183/16000617.0111-2018DOI Listing
June 2019
1 Read

A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome.

Crit Care 2019 Apr 17;23(1):128. Epub 2019 Apr 17.

Division of Pediatric Critical Care Medicine, Department of Pediatrics and Communicable Diseases, University of Michigan, 1500 East Medical Center Dr, F6790/5243, Ann Arbor, MI, 48109, USA.

Background: The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure at risk for PARDS has not been examined. The purpose of this study was to examine the association of early and sequential measurement of plasma IL-8 and/or its genetic variants with development of PARDS and other clinical outcomes in mechanically ventilated children with acute respiratory failure.

Methods: This was a prospective cohort study of children 2 weeks to 17 years of age with acute airways and/or parenchymal lung disease done in 22 pediatric intensive care units participating in the multi-center clinical trial, Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE). Read More

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http://dx.doi.org/10.1186/s13054-019-2342-8DOI Listing

Exploring the science, safety, and benefits of air care products: perspectives from the inaugural air care summit.

Inhal Toxicol 2019 Apr 18:1-13. Epub 2019 Apr 18.

q Drug and Poison Information Center , Cincinnati Children's Hospital , Cincinnati , OH , USA.

Seventy-one percent of US households purchase air care products. Air care products span a diverse range of forms, including scented aerosol sprays, pump sprays, diffusers, gels, candles, and plug-ins. These products are used to eliminate indoor malodors and to provide pleasant scent experiences. Read More

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http://dx.doi.org/10.1080/08958378.2019.1597221DOI Listing

Does ISWT evaluate maximal exercise capacity in subjects with severe asthma?

Respirology 2019 Apr 17. Epub 2019 Apr 17.

Department of Physical Therapy, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13563
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http://dx.doi.org/10.1111/resp.13563DOI Listing
April 2019
1 Read

The Cytokines of Asthma.

Immunity 2019 Apr;50(4):975-991

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, USA.

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. "Type 2-low" asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.018DOI Listing

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Groningen, University Medical Center Groningen, Pathology and Medical Biology, Groningen, Netherlands.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease. Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2018-0416TR
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http://dx.doi.org/10.1165/rcmb.2018-0416TRDOI Listing
April 2019
1 Read

Modern Inflammatory Phenotyping of Asthma: Breathomics is Here to Stay.

Authors:
Peter J Sterk

Am J Respir Crit Care Med 2019 Apr 17. Epub 2019 Apr 17.

University of Amsterdam, Academic Medical Center, Pulmonology, F5-259, Amsterdam, Netherlands ;

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http://dx.doi.org/10.1164/rccm.201904-0733EDDOI Listing

IL-2 modulates Th2 cell responses to glucocorticosteroid: A cause of persistent type 2 inflammation?

Immun Inflamm Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

Background: Glucocorticosteroids (GCs) are the main treatment for asthma as they reduce type 2 cytokine expression and induce apoptosis. Asthma severity is associated with type 2 inflammation, circulating Th2 cells and higher GC requirements.

Objective: The aim of this study was to assess whether ex vivo production of interleukin 2 (IL-2), a T-cell survival factor, associated with clinical features of asthma severity, the proportion of blood Th2 cells and Th2 cell responses to GC. Read More

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http://dx.doi.org/10.1002/iid3.249DOI Listing

Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats.

J Pharm Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Effect of alpha-linolenic acid (ALA) against ovalbumin (OVA)-induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat.

Methods: Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0. Read More

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http://dx.doi.org/10.1111/jphp.13094DOI Listing

Preformulation and Evaluation of Tofacitinib as a Therapeutic Treatment for Asthma.

AAPS PharmSciTech 2019 Apr 16;20(5):167. Epub 2019 Apr 16.

Department of Pharmaceutical Sciences, University of Arizona, Tucson, Arizona, USA.

Preformulation studies on tofacitinib citrate, a small molecule JAK3 specific inhibitor, have not been previously reported in literature. We therefore conducted several preformulation studies on tofacitinib citrate, and its free base, to better understand factors that affect its solubility, stability, and solid-state characteristics. Further, the results of the preformulation studies helped facilitate the development of a nebulized formulation of tofacitinib citrate for inhalational delivery to house dust mite allergen-challenged, BALB/c mice as a potential treatment for eosinophilic asthma. Read More

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http://link.springer.com/10.1208/s12249-019-1377-0
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http://dx.doi.org/10.1208/s12249-019-1377-0DOI Listing
April 2019
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Comparing Prescribing and Dispensing Data of the PCORnet Common Data Model Within PCORnet Antibiotics and Childhood Growth Study.

EGEMS (Wash DC) 2019 Apr 12;7(1):11. Epub 2019 Apr 12.

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, US.

Researchers often use prescribing data from electronic health records (EHR) or dispensing data from medication or medical claims to determine medication utilization. However, neither source has complete information on medication use. We compared antibiotic prescribing and dispensing records for 200,395 patients in the National Patient-Centered Clinical Research Network (PCORnet) Antibiotics and Childhood Growth Study. Read More

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http://dx.doi.org/10.5334/egems.274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460498PMC

Reference Equations for the ADL-Glittre Test in Pediatric Subjects.

Respir Care 2019 Apr 16. Epub 2019 Apr 16.

Health and Sports Science Center, Physiotherapy Department and Postgraduate Program, Santa Catarina State University, Florianópolis, Brazil.

Background: The ADL-Glittre test (TGlittre) was initially proposed to evaluate the activities of daily life (ADL) of adults with COPD that involve activities with the upper limbs in addition to walking. Recently, the test has been adapted for children (TGlittre-P), but no reference values have been proposed for its use in this population. The main objective of this study was to develop reference equations for the pediatric adaptation of the TGlittre. Read More

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http://dx.doi.org/10.4187/respcare.06619DOI Listing

MEDITERRANEAN DIET AND ASTHMA: TIME FOR CLINICAL TRIALS IN CHILDREN.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):207-208

Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia; IMIB Bio-health Research Institute; and ARADyAL allergy network, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.aller.2019.04.001DOI Listing

The multifaceted roles of FOXM1 in pulmonary disease.

Cell Commun Signal 2019 Apr 16;17(1):35. Epub 2019 Apr 16.

Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.

Forkhead box M1 (FOXM1), a transcriptional regulator of G1/S and G2/M transition and M phase progression in the cell cycle, plays a principal role in many physiological and pathological processes. A growing number of studies have focused on the relationship between abnormal FOXM1 expression and pulmonary diseases, such as lung cancer, chronic obstructive pulmonary disease (COPD), asthma, acute lung injury (ALI), pulmonary fibrosis, and pulmonary arterial hypertension (PAH). These studies indicate that the FOXM1 regulatory network is a major predictor of poor outcomes, especially in lung cancer, and provide novel insight into various pulmonary diseases. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-019-0347-1DOI Listing
April 2019
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The Induced Smoothed lasso: A practical framework for hypothesis testing in high dimensional regression.

Stat Methods Med Res 2019 Apr 16:962280219842890. Epub 2019 Apr 16.

2 Dipartimento di Scienze Economiche, Aziendali e Statistiche, Università degli Studi di Palermo, Palermo, Italy.

This paper focuses on hypothesis testing in lasso regression, when one is interested in judging statistical significance for the regression coefficients in the regression equation involving a lot of covariates. To get reliable p-values, we propose a new lasso-type estimator relying on the idea of induced smoothing which allows to obtain appropriate covariance matrix and Wald statistic relatively easily. Some simulation experiments reveal that our approach exhibits good performance when contrasted with the recent inferential tools in the lasso framework. Read More

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http://dx.doi.org/10.1177/0962280219842890DOI Listing

Therapeutic Effect of C. Y. Cheng et T. M. Ai in Ovalbumin-Induced Murine Model of Asthma.

Int J Mol Sci 2019 Apr 15;20(8). Epub 2019 Apr 15.

Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Geonjae-ro 177, Naju-si, Jeollanam-do 58245, Korea.

C. Y. Cheng et T. Read More

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https://www.mdpi.com/1422-0067/20/8/1855
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http://dx.doi.org/10.3390/ijms20081855DOI Listing
April 2019
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Post-traumatic stress disorder and asthma risk: A nationwide longitudinal study.

Psychiatry Res 2019 Apr 10;276:25-30. Epub 2019 Apr 10.

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Background: Increasing evidence suggests that post-traumatic stress disorder (PTSD) interferes with the immunological system and is correlated with cardiovascular disease, respiratory disease, and chronic pain conditions. However, the association between PTSD and asthma remains unknown.

Methods: A total of 5518 patients with PTSD and 22,072 age- and sex-matched healthy individuals were enrolled between 2001 and 2009 and followed until the end of 2011. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.04.014DOI Listing
April 2019
2.467 Impact Factor

Physical activity and depression symptoms in women with chronic illness and the mediating role of health-related quality of life.

J Affect Disord 2019 Apr 8;252:294-299. Epub 2019 Apr 8.

University of Technology Sydney, Faculty of Health, PO Box 123 Broadway NSW 2007, Ultimo, NSW, Australia.

Background: The aim of this study was to determine the impact of physical activity on depression symptom severity in women 45 years and older with a chronic illness diagnosis, and explore relations between physical activity and psychological and health-related characteristics predicting depression symptoms.

Methods: 1932 women diagnosed with one of five chronic illnesses: asthma, depression, diabetes, osteoarthritis, or osteoporosis participated in a sub-study of the 45 and Up Study-a cross-sectional study of people aged 45 years and older. The survey included items measuring demographics, depression symptoms, health-related quality of life (HRQoL), health-related hardiness, sleep quality, and health behaviours, such as physical activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183161
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http://dx.doi.org/10.1016/j.jad.2019.04.057DOI Listing
April 2019
2 Reads
3.383 Impact Factor

Curcuma longa L. ameliorates asthma control in children and adolescents: A randomized, double-blind, controlled trial.

J Ethnopharmacol 2019 Apr 13:111882. Epub 2019 Apr 13.

Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil. Electronic address:

Ethnopharmacological Relevance: Roots of Curcuma longa L. are used as medicine for millennia. They possess several pharmacological properties, including anti-inflammatory action, and can be suitable for asthma treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183403
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http://dx.doi.org/10.1016/j.jep.2019.111882DOI Listing
April 2019
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Responses to biological therapies in eosinophilic severe asthma.

J Investig Allergol Clin Immunol 2019 Apr 16. Epub 2019 Apr 16.

Unidad de Asma Grave. Complejo Hospitalario de Navarra.

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http://dx.doi.org/10.18176/jiaci.0403DOI Listing

Identifying indoor air Penicillium species: a challenge for allergic patients.

J Med Microbiol 2019 Apr 16. Epub 2019 Apr 16.

2 Department of Parasitology Mycology, University Hospital of Besançon, Besançon, France.

Purpose: Penicillium is the most common mould isolated in housing. Penicillium chrysogenum is the only species tested by prick test or serology for allergic patients. The American Institute of Medicine has accepted Penicillium as an aetiological agent of rhinitis in children and adults and as an asthma agent in children. Read More

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http://dx.doi.org/10.1099/jmm.0.000960DOI Listing
April 2019
2 Reads

Usefulness of mannitol challenge testing for diagnosing asthma in everyday clinical practice.

J Asthma 2019 Apr 16:1-7. Epub 2019 Apr 16.

a Respiratory Research Unit, Department of Respiratory Medicine , Hvidovre Hospital , Hvidovre , Denmark.

Background: The mannitol test is widely used for assessment of airway responsiveness in patients with possible asthma, but our knowledge of the value in everyday clinical practice is limited.

Objective: To investigate the diagnostic value of the mannitol test in a clinical setting.

Methods: All patients having a mannitol challenge test as part of their diagnostic work-up for asthma at the respiratory outpatient clinic, Hvidovre Hospital, over a 5-year period were included in the present analysis. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2019.1
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http://dx.doi.org/10.1080/02770903.2019.1600144DOI Listing
April 2019
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[Mufangji Decoction formula tracing and its effect on emergency and severe cases].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):388-400

Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.

Mufangji Decoction is a famous herbal formula from Synopsis of Golden Chamber. However,it is easy to be misunderstood due to so its unique compatability. The syndromes treated by Mufangji Decoction included the following aspects:(1) in terms of modern medicine,it could be used to treat acute and chronic heart failure,heart failure aggravated by lung infection,chronic obstructive pulmonary disease acute episode,pulmonary heart disease,bilateral pleural effusion,acute attack of gout,rheumatic fever,rheumatoid arthritis,and rheumatoid arthritis;(2) in terms of symptoms,it could be used to treat asthma,chest tightness,wheeze impacting prostration and dyspnea impacting sitting posture; gastric distention; dark face,cyanotic,and mitral valvular face; edema of head and extremities; dry mouth,thirsty,unwilling to wear thick clothes,intolerance of heat,and irritable; fatigue,shortness of breath,poor appetite,constipation,less urine,yellow color,poor response to diuretics,and diuretic resistance; fast heart rate,which is hard to be controlled by Western medicine and has no response to Zhenwu Decoction; dark red tongue,dry tongue with yellow fur,rapid pulse,or deep tight pulse. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.2019.0009
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http://dx.doi.org/10.19540/j.cnki.cjcmm.2019.0009DOI Listing
January 2019
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Direct assessment of skin epithelial barrier by electrical impedance spectroscopy.

Allergy 2019 Apr 16. Epub 2019 Apr 16.

Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.

Background: Many skin and mucosal inflammatory disorders, such as atopic dermatitis, have been associated with an impaired epithelial barrier function, which allows allergens, pollutants or microbes to enter the tissue and activate the immune response. The aim of this study was to establish a method to directly assess in vivo the epidermal barrier function by electrical impedance (EI) spectroscopy.

Methods: Mice epidermal barrier was damaged by epicutaneous application of proteases and cholera toxin and by tape stripping. Read More

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http://dx.doi.org/10.1111/all.13824DOI Listing

The role of invariant T cells in inflammation of the skin and airways.

Semin Immunopathol 2019 Apr 15. Epub 2019 Apr 15.

Centre for Cancer Biology, The University of South Australia and SA Pathology, North Terrace, Adelaide, SA, 5000, Australia.

Invariant and semi-invariant T cells are emerging as important regulators of host environment interactions at barrier tissues such as the airway and skin. In contrast to conventional T cells, invariant natural killer T (iNKT) cells and mucosal associated invariant T (MAIT) cells express T cell receptors of very limited diversity. iNKT and MAIT cells recognise antigens presented by the MHC class 1-like monomorphic molecules CD1d and MR1, respectively. Read More

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http://link.springer.com/10.1007/s00281-019-00740-9
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http://dx.doi.org/10.1007/s00281-019-00740-9DOI Listing
April 2019
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P-ANCA negative eosinophilic granulomatosis with polyangiitis.

Respir Med Case Rep 2019 28;27:100830. Epub 2019 Mar 28.

Department of Pathology, Southern Illinois University, Springfield, IL, USA.

Vasculitis refers to inflammation of the systemic vessels. Eosinophilic granulomatosis with polyangiitis (EGPA) is a medium and small vessel vasculitis characterized by hypereosinophilia, pulmonary infiltrates, difficult to treat asthma and polyneuropathies. Diagnosis can often be challenging. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.100830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446216PMC

Upper airway wheezing: Inducible laryngeal obstruction vs. excessive dynamic airway collapse.

Respir Med Case Rep 2019 28;27:100827. Epub 2019 Mar 28.

University of Texas Health Science Center at San Antonio, Pulmonary/Critical Care, USA.

There are multiple causes of dyspnea upon exertion in young, healthy patients to primarily include asthma and exercise-induced bronchospasm. (EDAC) describes focal collapse of the trachea or main bronchi with maintained structural integrity of the cartilaginous rings. It is commonly associated with pulmonary disorders like bronchiectasis, chronic obstructive pulmonary disease and asthma. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.100827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446124PMC

Communication channels for air quality alerts in the United States.

Prev Med Rep 2019 Jun 28;14:100860. Epub 2019 Mar 28.

Asthma and Community Health Branch, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F-60, Atlanta, GA 30341, USA.

Short-term exposure to air pollution can result in acute health effects, particularly for individuals with respiratory and cardiovascular disease. Air quality alert programs that notify the public about high air pollution days are critical for susceptible populations. We assessed how U. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113355193004
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http://dx.doi.org/10.1016/j.pmedr.2019.100860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449704PMC
June 2019
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A Pharmacological Review on L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities.

J Pharmacopuncture 2019 Mar 31;22(1):7-15. Epub 2019 Mar 31.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

. (PO) or Purslane is an annual grassy plant that is distributed in many parts of the world, especially the tropical and subtropical areas. PO has some pharmacological properties such as analgesic, antibacterial, skeletal muscle-relaxant, wound-healing, anti- inflammatory and a radical scavenger. Read More

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http://dx.doi.org/10.3831/KPI.2019.22.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461301PMC

Food Allergen Sensitisation Patterns in Omani Patients with Allergic Manifestations.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e483-e488. Epub 2019 Mar 28.

Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.

Objectives: This study aimed to evaluate the relationship between food allergen sensitisation patterns and allergic manifestations in Omani patients and highlight the importance of specific immunoglobulin E (IgE) testing.

Methods: This retrospective study included all patients referred due to allergic manifestations to the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, from November 2012 to November 2016. Specific IgE blood testing was performed to determine sensitisation to common foods known to cause allergic reactions. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/299
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http://dx.doi.org/10.18295/squmj.2018.18.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443266PMC
November 2018
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