188,351 results match your criteria Asthma


Is the e-cigarette harmless among asthmatic patients?

Respirology 2020 May 26. Epub 2020 May 26.

Department of Cardiology, Erasme Hospital, Université Libre de Bruxelles, Bruxelles, Belgium.

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http://dx.doi.org/10.1111/resp.13868DOI Listing

Sterilization plan of the used metered dose inhalers (MDI) to avoid wastage amid COVID-19 pandemic drug shortage.

Authors:
Ali Elbeddini

J Pharm Policy Pract 2020 20;13:19. Epub 2020 May 20.

Chairman of Pharmacy and patient safety officer for Winchester Hospital, Winchester District Memorial Hospital (WDMH), 556 Louise St, Winchester, ON K0C2K0 Canada.

Background Coronavirus is causing a shortage of critical inhalers needed by patients with Asthma and respiratory illness. Patients with Asthma are at higher risk if they tract the novel Coronavirus. As the coronavirus continues to spread, hospitals are turning to use more salbutamol MDI. Read More

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http://dx.doi.org/10.1186/s40545-020-00224-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237800PMC

REGRESSION OF THE NAVIER-STOKES EQUATION SOLUTIONS FOR PULMONARY AIRWAY FLOW USING NEURAL NETWORKS.

Proc IEEE Int Symp Biomed Imaging 2019 Apr 11;2019:1229-1233. Epub 2019 Jul 11.

Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.

Computerized fluid dynamics models of particle deposition in the human airways are used to characterize deposition patterns that enable the study of lung diseases like asthma and chronic obstructive pulmonary disease (COPD). Despite this fact, the influence of patient-specific geometry on the deposition efficiency and patterns is not well documented nor modeled. In part, this is due to the complexity of simulating the full Computational Fluid Dynamics (CFD) solution in patient-specific airway geometries, a factor that becomes a major hurdle for patient-specific studies given the complexity of the geometry of human lungs and their related airflow. Read More

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http://dx.doi.org/10.1109/isbi.2019.8759186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243963PMC

Retrospective analysis of epidemic thunderstorm asthma in children in Yulin, northwest China.

Pediatr Res 2020 May 26. Epub 2020 May 26.

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: An epidemic of thunderstorm asthma in pediatric patients occurred in Yulin, a northwest city of China, on 11 September 2018. We described the epidemic and retrospectively analyzed the demographic and clinical aspects of the involved children.

Methods: The caseload data of patients were collected from the hospital information system in Yulin Pediatric Hospital. Read More

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http://dx.doi.org/10.1038/s41390-020-0980-9DOI Listing

YiQi GuBen Formula Inhibits PDGF-BB-Induced Proliferation and Migration of Airway Smooth Muscle Cells.

Pharmacology 2020 May 26:1-10. Epub 2020 May 26.

Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China,

Objective: Increased proliferation and migration of airway smooth muscle cells (ASMCs) are key events in the development of asthma. YiQi GuBen is a traditional Chinese medicinal formula shown to effectively reduce the recurrence rate of asthma and induce anti-asthma effects through multiple pathways; however, its potential role in regulating ASMC proliferation and preventing bronchial asthma remains unexplored.

Methods: This study investigated the effects of YiQi GuBen formula on platelet-derived growth factor (PDGF)-BB-induced ASMC proliferation and migration by methylthiazolyldiphenyl-tetrazolium bromide, wound healing, transwell, and cell cycle assays. Read More

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http://dx.doi.org/10.1159/000504516DOI Listing

Immune semaphorins: Crucial regulatory signals and novel therapeutic targets in asthma and allergic diseases.

Eur J Pharmacol 2020 May 23:173209. Epub 2020 May 23.

Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran; Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address:

Asthma and allergic diseases are a group of chronic inflammatory disorders that arise as a result of excessive responses of the immune system against intrinsically harmless environmental substances. It is well known that substantial joint characteristics exist between the immune and nervous systems. The semaphorins (Semas) were initially characterized as axon-guidance molecules that play a crucial role during the development of the nervous system. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173209DOI Listing

Prevention and Treatment of Recurrent Viral-Induced Wheeze in the Preschool Child.

Ann Allergy Asthma Immunol 2020 May 23. Epub 2020 May 23.

Robert C. Strunk Endowed Chair for Lung and Respiratory Research, Professor of Pediatrics Clinical Director, Division of Allergy, Immunology and Pulmonary Medicine, St. Louis Children's Hospital 1 Children's Place St. Louis, MO 63110. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.05.018DOI Listing

Outside-in hypothesis revisited: the role of microbial, epithelial and immune interactions.

Ann Allergy Asthma Immunol 2020 May 23. Epub 2020 May 23.

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland; Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.

Objective: Our understanding of the origin of allergic diseases has increased in recent years, highlighting the importance of microbial dysbiosis and epithelial barrier dysfunction in affected tissues. Exploring the microbial-epithelial-immune crosstalk underlying the mechanisms of allergic diseases will allow the development of novel prevention and treatment strategies of allergic diseases.

Data Sources: This review summarizes recent advances in microbial, epithelial, and immune interactions in atopic dermatitis, allergic rhinitis, chronic rhinosinusitis and asthma. Read More

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http://dx.doi.org/10.1016/j.anai.2020.05.016DOI Listing

The Need for Patient Voices in Food Allergy Research.

Ann Allergy Asthma Immunol 2020 May 23. Epub 2020 May 23.

Department of Pediatrics and Child Health, The University of Manitoba, Canada; George and Fay Yee Centre for Healthcare Innovation, Winnipeg, Canada; The Children's Health Research Institute of Manitoba, Winnipeg, Canada; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Food and Human Nutritional Sciences, The University of Manitoba, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.05.017DOI Listing

Recognizing asthma in patients with chronic obstructive pulmonary disease.

J Am Assoc Nurse Pract 2020 May 21. Epub 2020 May 21.

Emory University, Nell Hodgson Woodruff School of Nursing, Atlanta, Georgia.

Newer guidelines for the use of inhaled corticosteroids in chronic obstructive pulmonary disease (COPD) state that they should be reserved for those patients who are likely to derive the greatest benefits from this medication class. This makes the latest Global Initiative for Chronic Obstructive Lung disease (GOLD) guidelines of great importance. This article examines the utility of a previous diagnosis of asthma, the presence of eosinophilia, elevated immunoglobulin E, and positive bronchodilator response in identifying the people with COPD who also have asthma, and it presents two case studies of patients with COPD to illustrate the use of the GOLD guidelines in clinical practice. Read More

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http://dx.doi.org/10.1097/JXX.0000000000000405DOI Listing

Treating asthma in the age of biologics.

JAAPA 2020 Jun;33(6):48-50

Anisha Prabakaran practices at West Houston (Tex.) Allergy and Asthma. The author has disclosed no potential conflicts of interest, financial or otherwise.

Many patients with severe asthma continue to have high symptom burden despite maximization of conventional therapy. As the understanding of asthma pathophysiology has evolved, however, more personalized therapy options have become available. Asthma biologics are a new class of medications that target the specific pathways that underlie a patient's disease and can reduce the frequency of asthma exacerbations and improve patient quality of life. Read More

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http://dx.doi.org/10.1097/01.JAA.0000657220.41861.2dDOI Listing

Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks.

Allergy 2020 May 26. Epub 2020 May 26.

Allergy and Asthma Research Associates, Dallas, Texas, USA.

Background: Lanadelumab demonstrated efficacy in preventing HAE attacks in the phase 3 HELP Study.

Objective: To assess time to onset of effect and long-term efficacy of lanadelumab, based on exploratory findings from the HELP Study.

Methods: Eligible patients with HAE type I/II received lanadelumab 150 mg every 4 weeks (q4wks), 300 mg q4wks, 300 mg q2wks, or placebo. Read More

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http://dx.doi.org/10.1111/all.14416DOI Listing

Validation of the ARIA items to assess allergic rhinitis control (ARIA-C).

Allergy 2020 May 25. Epub 2020 May 25.

CIBERES, Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1111/all.14418DOI Listing

Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes.

Nat Commun 2020 May 25;11(1):2607. Epub 2020 May 25.

Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.

Quantification of pathogen and host biomarkers is essential for the diagnosis, monitoring, and treatment of infectious diseases. Here, we demonstrate sensitive and rapid quantification of bacterial load and cytokines from human biological samples to generate actionable hypotheses. Our digital assay measures IL-6 and TNF-α proteins, gram-negative (GN) and gram-positive (GP) bacterial DNA, and the antibiotic-resistance gene bla with femtomolar sensitivity. Read More

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http://dx.doi.org/10.1038/s41467-020-16124-9DOI Listing

Anxiety, depression, and stress in Korean patients with chronic urticaria.

Korean J Intern Med 2020 May 27. Epub 2020 May 27.

Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

Background/aims: Emotional distress is thought to cause or maintain chronic urticaria (CU). We aimed to investigate the presence of anxiety, depression, and stress in Korean adult CU patients and to explore their potential impact on treatment.

Methods: We enrolled 79 CU patients and a disease control group comprising 39 persistent asthma patients. Read More

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http://dx.doi.org/10.3904/kjim.2019.320DOI Listing

[Effects of bronchial thermoplasty on airway remodeling, asthma control and quality of life in patients with severe asthma].

Zhonghua Yi Xue Za Zhi 2020 May;100(20):1573-1577

Department of Respiratory and Critical Care Medicine, China Japan Friendship Hospital, Beijing 100029, China.

To investigate the effects of bronchial thermoplasty (BT) on airway remodeling, asthma control and quality of life in patients with severe asthma. From January to September 2019, 11 patients with severe asthma were recruited from China Japan Friendship Hospital to receive BT treatment. The treatment was performed over three sessions separated by 3-week intervals. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200217-00311DOI Listing

Isolation, Anti-Inflammatory Activity and Physico-chemical Properties of Bioactive Polysaccharides from Fruiting Bodies of Cultivated Cordyceps cicadae (Ascomycetes).

Int J Med Mushrooms 2019 ;21(10):995-1006

Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan.

Cordyceps cicadae is a medicinal fungus popularly used in traditional Chinese medicine for treating cancer, asthma, and kidney diseases. In this study, crude polysaccharides (CP) and water-soluble nondigestible polysaccharides (NDPs) were prepared from the fruiting bodies of cultivated C. cicadae, and their physicochemical properties and anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019031922DOI Listing
January 2019

Efficacy and safety of mepolizumab in Korean patients with severe eosinophilic asthma from the DREAM and MENSA studies.

Korean J Intern Med 2020 May 26. Epub 2020 May 26.

Respiratory Medical Franchise, GSK, Brentford, UK.

Background/aims: The efficacy and safety of mepolizumab in patients with severe eosinophilic asthma has been evaluated in a global clinical trial programme. This post hoc analysis assesses the efficacy and safety of mepolizumab in Korean patients.

Methods: Data from Korean patients in the Phase III, placebo-controlled, randomised DREAM (MEA112997/NCT01000506) and MENSA (MEA115588/ NCT01691521) studies were included. Read More

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http://dx.doi.org/10.3904/kjim.2019.198DOI Listing

CCL5 persists in RSV stocks following sucrose-gradient purification.

J Leukoc Biol 2020 May 25. Epub 2020 May 25.

Departments of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Respiratory syncytial virus (RSV) is associated with bronchiolitis in infancy and the later development of asthma. Research on RSV in vitro requires preparation of a purified RSV stock. The objective for this work was to develop best methods for RSV purification, while monitoring the samples for potential contaminating proinflammatory mediators. Read More

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http://dx.doi.org/10.1002/JLB.4MA0320-621RDOI Listing

Warifteine and methylwarifteine inhibited the type 2 immune response on combined allergic rhinitis and asthma syndrome (CARAS) experimental model through NF-кB pathway.

Int Immunopharmacol 2020 May 21;85:106616. Epub 2020 May 21.

Laboratório de Imunofarmacologia, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brazil. Electronic address:

CARAS is an airway inflammation of allergic individuals, with a type 2 immune response. The pharmacotherapy is based on drugs with relevant side effects. Thus, the goal of this study evaluated the alkaloids warifteine (War) and methylwarifteine (Mwar) from Cissampelos sympodialis in CARAS experimental model. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106616DOI Listing

Stereotactic radiotherapy combined with immunotherapy against metastatic melanoma: Long term results of a phase I clinical trial.

Int J Radiat Oncol Biol Phys 2020 May 22. Epub 2020 May 22.

Alfred Health Radiation Oncology, The Alfred Hospital, Melbourne, Australia; Monash University, Melbourne, Australia.

Purpose: To determine the maximum tolerated dose (MTD) of stereotactic ablative radiotherapy (SABR) in combination with immunotherapy for the treatment of metastatic melanoma. The study also investigates the effects of timing and dosing of SABR on clinical efficacy.

Methods: Metastatic melanoma patients with at least two metastases received SABR to a single metastatic site. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.05.022DOI Listing

Clinical phenotypes of atopy and asthma in COPD: a meta-analysis of SPIROMICS and COPDGene.

Chest 2020 May 22. Epub 2020 May 22.

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Little is known about the concordance of atopy with asthma COPD overlap (ACO). Among individuals with COPD, a better understanding of the phenotypes characterized by asthma overlap and atopy is needed to better target therapies.

Research Question: What is the overlap between atopy and asthma status among individuals with COPD, and how are categories defined by the presence of atopy and asthma status associated with clinical and radiologic phenotypes and outcomes in the SPIROMICS and COPDGene studies?

Study Design And Methods: 403 individuals with COPD from SPIROMICS and 696 individuals from COPDGene with data about specific IgEs to 10 common allergens and mixes (simultaneous assessment of combination of allergens in similar category) were included. Read More

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http://dx.doi.org/10.1016/j.chest.2020.04.069DOI Listing

A Phased Approach to Resuming Suspended Allergy/Immunology Clinical Services.

J Allergy Clin Immunol Pract 2020 May 22. Epub 2020 May 22.

Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:

In early 2020, the first US and Canadian cases of the novel SARS-CoV-2 infection were detected. In the ensuing months, there has been rapid spread of the infection. In March 2020, in response to the virus, state/provincial and local governments instituted shelter-in-place orders, and non-essential ambulatory care was significantly curtailed, including allergy/immunology services. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.012DOI Listing

Insights on the participation of Glu256 and Asp204 in the oligomeric structure and cooperative effects of human arginase type I.

J Struct Biol 2020 May 22:107533. Epub 2020 May 22.

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile. Electronic address:

Arginase (EC 3.5.3. Read More

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http://dx.doi.org/10.1016/j.jsb.2020.107533DOI Listing

Circular RNA circHIPK3 modulates the proliferation of airway smooth muscle cells by miR-326/STIM1 axis.

Life Sci 2020 May 22:117835. Epub 2020 May 22.

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital affiliated to Capital Medical University, Beijing 100020, China.

Aims: Emerging findings demonstrate the critical roles of noncoding RNA (ncRNA) in asthma development. Nevertheless, the biological roles of circular RNA (circRNA) in airway remodeling are still elusive. Here, the present research focuses on the regulation of circRNA circHIPK3 in airway smooth muscle cells (ASMCs) proliferation and migration. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117835DOI Listing

ACE2, TMPRSS2 AND FURIN GENE EXPRESSION IN THE AIRWAYS OF PEOPLE WITH ASTHMA - IMPLICATIONS FOR COVID-19.

J Allergy Clin Immunol 2020 May 22. Epub 2020 May 22.

National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (Respiratory theme) and College of Life Sciences, University of Leicester, UK.

To-date, there has not been a clear signal suggesting that asthma or treatment with inhaled steroids are a risk factor for severe COVID-19 disease. We have therefore explored ACE2 receptor mRNA expression, and co-factors for Sars-CoV-2 infectivity (TMPRSS2 and furin) in bronchial brushes and biopsies from people with asthma and healthy controls, and looked for relationships between asthma severity, Th2- and IL-17 dependent gene signatures, and clinical demographics (age, sex). We have looked at a cohort of 356 research participants from previously described studies. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.05.013DOI Listing

Propranolol is an effective topical and systemic treatment option for experimental epidermolysis bullosa acquisita.

J Invest Dermatol 2020 May 22. Epub 2020 May 22.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany. Electronic address:

Propranolol is a ß-adrenoreceptor type 2 (ADRB2) blocker that regulates heart muscle contractions, smooth muscle relaxation and glycogenolysis. In addition, an increasing number of applications in dermatology have been described; most prominently, the use as a first-line treatment for infantile hemangiomas. We here show that propranolol enhances IL-8-induced neutrophil chemotaxis and reduces the release of reactive oxygen species (ROS) after immune complex (IC) stimulation. Read More

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http://dx.doi.org/10.1016/j.jid.2020.04.025DOI Listing

Psychometric evaluation of the Brazilian version of the pediatric asthma control and communication instrument.

Pediatr Pulmonol 2020 May 25. Epub 2020 May 25.

Department of Physical Therapy, Graduate Program in Physical Therapy, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Background: There is a lack of questionnaires capable of evaluating the clinical control of Brazilian children and adolescents with asthma over a wide age range. The Pediatric Asthma Control and Communication Instrument (PACCI) has been validated, but only with English- and Spanish-speaking children in the United States.

Objectives: To evaluate the psychometric properties of the Brazilian version of the PACCI questionnaire. Read More

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http://dx.doi.org/10.1002/ppul.24851DOI Listing

Validation of the MASK-air App for assessment of allergic rhinitis.

Allergy 2020 May 25. Epub 2020 May 25.

CIBERES, Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1111/all.14415DOI Listing

Breathing pattern disorders (dysfunctional breathing) characteristics and outcomes of children and young people attending a secondary care respiratory clinic.

Pediatr Pulmonol 2020 May 25. Epub 2020 May 25.

Speech and Language Department, Kent Community NHS Foundation Community Trust, Kent, UK.

Methods: We retrospectively audited the health records of 18 patients with breathing pattern disorders (BPDs), who were diagnosed in our respiratory clinic (2015-2018), and then referred onto our dysfunctional breathing care pathway to a specialist speech and language therapist.

Results: The age of the patients ranged from 11 to 16 years (median: 14 years, 14 female/4 male patients). Comorbidities included the following: 16 patients had asthma, 2 patients had a tracheoesophageal fistula and esophageal atresia repair, one patient suffered from chronic regional pain syndrome, and one patient had chronic fatigue syndrome. Read More

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http://dx.doi.org/10.1002/ppul.24791DOI Listing

Patient-oriented Eczema Measure score: a Useful Tool for Web-Based Surveys in Patients with Atopic Dermatitis.

Acta Derm Venereol 2020 May 25. Epub 2020 May 25.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 812-8582 Fukuoka, Japan. E-mail:

The Patient-Oriented Eczema Measure (POEM, 0-28 points) is a self-assessed, repeatable measurement tool for measuring atopic dermatitis (AD) severity. How-ever, whether POEM score is influenced by allergic comorbidities and whether POEM's severity banding is applicable in web-based surveys for AD remain unclear. A web-based questionnaire survey was conducted in 329 patients with AD. Read More

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http://dx.doi.org/10.2340/00015555-3530DOI Listing

Spontaneous pneumothorax caused by an inflammatory myofibroblastic tumor-like lesion in a 14-year-old girl: a case report.

Surg Case Rep 2020 May 24;6(1):109. Epub 2020 May 24.

Division of Pediatric Surgery, Department of Surgery, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510, Japan.

Background: Spontaneous pneumothorax occurs more often in younger, slim, and shallow-chested men. Although less common, differential diagnoses for secondary pneumothorax in children are asthma, emphysematous blebs, catamenial pneumothorax, and others. We report a patient who presented with pneumothorax and was found to have an inflammatory myofibroblastic tumor (IMT)-like lesion, and present a review of the related literature. Read More

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http://dx.doi.org/10.1186/s40792-020-00873-2DOI Listing

Pharmacists experience of and perspectives about recruiting patients into a community pharmacy asthma service trial.

Res Social Adm Pharm 2020 May 16. Epub 2020 May 16.

The University of Sydney -The University of Sydney, A15, Science Rd, Camperdown, NSW, 2006, Australia. Electronic address:

Background: Research trials testing the impact of community pharmacy services require adequate and appropriate recruitment of patients by participating pharmacists, however, this step presents an ongoing challenge.

Objective: To identify factors affecting recruitment of patients in community pharmacies participating in a multi-center trial of a pharmacy asthma service in Australia (Pharmacy Trial Program - Asthma and Rhinitis Control (PTP-ARC).

Methods: The PTP-ARC protocol required identification and recruitment of seven eligible asthma patients per pharmacy. Read More

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http://dx.doi.org/10.1016/j.sapharm.2020.05.012DOI Listing

Reply.

J Allergy Clin Immunol 2020 May 21. Epub 2020 May 21.

ALK-Abelló A/S, Hørsholm, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.03.011DOI Listing

Common variable immunodeficiency and asthma: Coexistence or coincidence?

Ann Allergy Asthma Immunol 2020 Jun;124(6):635

Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Larissa, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.02.013DOI Listing

Drug allergy labeling and delabeling in the coronavirus disease 2019 era: What is important and what do we need to know.

Ann Allergy Asthma Immunol 2020 Jun;124(6):523-525

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.04.012DOI Listing

Metabolomic fingerprinting and systemic inflammatory profiling of asthma COPD overlap (ACO).

Respir Res 2020 May 24;21(1):126. Epub 2020 May 24.

School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.

Background: Asthma-COPD overlap (ACO) refers to a group of poorly studied and characterised patients reporting with disease presentations of both asthma and COPD, thereby making both diagnosis and treatment challenging for the clinicians. They exhibit a higher burden in terms of both mortality and morbidity in comparison to patients with only asthma or COPD. The pathophysiology of the disease and its existence as a unique disease entity remains unclear. Read More

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http://dx.doi.org/10.1186/s12931-020-01390-4DOI Listing

[Pemphigoid reaction by specific allergen immunotherapy: An unusual adverse reaction].

Rev Alerg Mex 2020 Jan-Mar;67(1):83-86

Instituto de Investigación Sanitaria, Servicio de Alergología, Hospital Universitario La Paz, Madrid, España.

Background: For the most part, adverse reactions caused by subcutaneous allergen-specific immunotherapy (AIT) are directly induced by the administration of an allergen; there is usually redness and induration at the area of the injection. Other skin lesions are extremely unusual.

Case Report: A 40-year-old woman with allergic rhinoconjunctivitis and asthma due to sensitization to grass pollen had received monthly doses of 0. Read More

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http://dx.doi.org/10.29262/ram.v67i1.671DOI Listing

[The effectiveness of omalizumab in the control of severe uncontrolled asthma in Latin America. An exploratory systematic review and meta-analysis].

Authors:
Pablo Miranda

Rev Alerg Mex 2020 Jan-Mar;67(1):19-24

ALZAK Foundation, Bolívar, Colombia.

Background: Omalizumab is effective in the treatment of severe persistent allergic asthma that is not controlled with long-acting beta-agonists/ high-dose inhaled corticosteroids.

Objective: To conduct a systematic exploratory review and meta-analysis of studies with omalizumab in Latin America.

Methods: A search of real-life studies on the effectiveness of omalizumab in asthma control conducted in Latin America was carried out. Read More

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http://dx.doi.org/10.29262/ram.v67i1.701DOI Listing

[Effect of acupuncture and moxibustion at "Feishu"Dazhui"and "Fengmen"on the expression of CC chemokine ligand 1 and CC chemokine receptor 8 in lung tissue of rats with asthma].

Zhen Ci Yan Jiu 2020 May;45(5):363-7

The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China.

Objective: To investigate the protein expression of CC chemokine ligand 1 (CCL1) and CC chemokine receptor 8 (CCR8) in the lung tissue of rats and the mechanism of acupuncture and moxibustion at "Feishu"(BL13), "Dazhui" (GV14) and "Fengmen"(BL12) in the treatment of asthma.

Methods: Sprague-Dawley rats were randomly divided into blank, model, acupuncture and moxibustion groups,=10 in each group. Ovalbumin sensitization via intraperitoneal injection was performed to establish a model of asthma. Read More

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http://dx.doi.org/10.13702/j.1000-0607.190394DOI Listing

Phosphodiesterase 4 inhibitors attenuate virus-induced activation of eosinophils from asthmatics without affecting virus binding.

Pharmacol Res Perspect 2020 Jun;8(3):e00557

Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam, The Netherlands.

Acute respiratory virus infections, such as influenza and RSV, are predominant causes of asthma exacerbations. Eosinophils act as a double-edged sword in exacerbations in that they are activated by viral infections but also can capture and inactivate respiratory viruses. Phosphodiesterase type 4 (PDE4) is abundantly expressed by eosinophils and has been implicated in their activation. Read More

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http://dx.doi.org/10.1002/prp2.557DOI Listing

The Ramapough Lunaape Nation: Facing Health Impacts Associated with Proximity to a Superfund Site.

J Community Health 2020 May 23. Epub 2020 May 23.

Department of Environmental Medicine, New York University Grossman School of Medicine, 341 East 25th Street, New York, NY, 10010, USA.

This study aimed to evaluate self-reported exposure to the Ringwood Mines/Landfill Superfund Site in relation to chronic health outcomes among members of the Ramapough Lunaape Turtle Clan nation and other local residents of Ringwood, New Jersey. Community surveys on personal exposure to the nearby Superfund site, self-reported health conditions, and demographics were conducted with 187 members of the Ramapough Lunaape Turtle Clan Nation and non-Native Americans residing in Ringwood, New Jersey from December 2015 to October 2016. Multiple logistic regression was performed to assess the association between ethnicity and a Superfund site exposure score developed for this study, as well as between exposure score and several chronic health conditions. Read More

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http://dx.doi.org/10.1007/s10900-020-00848-2DOI Listing

Childhood asthma heterogeneity at the era of precision medicine: Modulating the immune response or the microbiota for the management of asthma attack.

Biochem Pharmacol 2020 May 21:114046. Epub 2020 May 21.

Univ. Lille, INSERM Unit 1019, CNRS UMR 9017 CHU Lille, Institut Pasteur de Lille, Center for infection and immunity of Lille, F-59019 Lille cedex, France. Electronic address:

Exacerbations are a main characteristic of asthma. In childhood, the risk is increasing with severity. Exacerbations are a strong phenotypic marker, particularly of severe and therapy-resistant asthma. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242211PMC

School-Based Telemedicine Interventions for Asthma: A Systematic Review.

Acad Pediatr 2020 May 21. Epub 2020 May 21.

Department of Family and Community Medicine, 4860 Y St, Suite 1600. Sacramento, CA 95817 USA. Electronic address:

Background: School health systems are increasingly investing in telemedicine platforms to address acute and chronic illnesses. Asthma, the most common chronic illness in childhood, is of particular interest given its high burden on school absenteeism.

Objectives: Conduct a systematic review evaluating impact of school-based telemedicine programs on improving asthma-related outcomes. Read More

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http://dx.doi.org/10.1016/j.acap.2020.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241375PMC

Dust mite-derived Enterobacterial fimbriae H protein enforces the allergen specific immunotherapy in asthma mice.

Allergol Immunopathol (Madr) 2020 May 20. Epub 2020 May 20.

State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, 518060, China; Guangzhou Institute of Respiratory Diseases, State Key Lab of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China. Electronic address:

Background: The mite alimentary canal contains plenty of microbiota. It is accepted that some of the microbial products function as adjuvants to speed up immune responses.

Objectives: We identified five bacterial proteins from dust mite, and Enterobacterial fimbriae H (FimH) was one of them. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.012DOI Listing

Maximizing the role of the nurse: Strategies to address gaps in asthma care in schools.

J Pediatr Nurs 2020 May 20;53:52-56. Epub 2020 May 20.

Vanderbilt University School of Nursing, 461 21st Avenue South, Nashville, TN 37240, United States of America.

Purpose: The purpose of this project was to describe differences in the numbers of children with a diagnosis of asthma identified through two methods, determine barriers to receiving asthma interventions in elementary school settings, and make recommendations for action and advocacy for school nurses to increase the number of children with access to asthma medications at school.

Design And Methods: The authors conducted a review of the asthma diagnosis process from the initial identification of a diagnosis to the delivery of interventions with 349 enrolled students in one large, urban public school in Tennessee.

Results: Sixty children were identified using the school's existing parent identification process and 91 children who participated in a concurrent asthma education program self-identified or were referred by a teacher, staff, or administrator. Read More

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http://dx.doi.org/10.1016/j.pedn.2020.05.003DOI Listing

Dibutyl phthalate aggravated asthma-like symptoms through oxidative stress and increasing calcitonin gene-related peptide release.

Ecotoxicol Environ Saf 2020 May 20;199:110740. Epub 2020 May 20.

Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, 430081, China; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, China. Electronic address:

Dibutyl phthalate (DBP) is one of the most ubiquitous phthalate esters found in everyday products, and is receiving increased attention as an immunologic adjuvant. However, information regarding DBP-aggravated allergic asthma is still limited. This study used a mouse model sensitized with ovalbumin (OVA) to determine any adverse effects of DBP on allergic asthma. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110740DOI Listing