206,690 results match your criteria Asthma

The new era of add-on asthma treatments: where do we stand?

Allergy Asthma Clin Immunol 2022 May 21;18(1):42. Epub 2022 May 21.

Division of Pulmonary, Critical Care, and Sleep Medicine, Yale Center for Asthma and Airway Disease, Yale University School of Medicine, New Haven, CT, USA.

Globally, a small proportion (5-12%) of asthma patients are estimated to have severe disease. However, severe asthma accounts for disproportionately high healthcare resource utilization. The Global Initiative for Asthma (GINA) management committee recommends treating patients with asthma with inhaled corticosteroids plus long-acting β-agonists and, when needed, adding a long-acting muscarinic receptor antagonist or biologic agent. Read More

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Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank.

BMC Med Genomics 2022 May 21;15(1):119. Epub 2022 May 21.

Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.

Background: The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring CNVs in large enough sample sizes to detect associations. The recent availability of whole-exome sequencing (WES) in large biobank studies provides an unprecedented opportunity to study the role of CNVs in asthma. Read More

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[Therapeutic adherence among asthma patients: Variations according to age groups. How can it be improved? The potential contributions of new technologies].

Rev Mal Respir 2022 May 18. Epub 2022 May 18.

Service de pneumologie, UF tabacologie, hôpital Tenon, DMU APPROCHES, Paris, France.

While asthma patients' treatment adherence (TA) generally leaves to be desired, few data exist on TA evolution from age group to another. During the meeting of a working group of pneumo-pediatricians and adult pulmonologists, we reviewed the literature on adherence according to age group, examined explanations for poor adherence, and explored ways of improving adherence via new technologies. Asthma is a chronic disease for which TA is particularly low, especially during adolescence, but also among adults. Read More

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Socioeconomic status associates with worse asthma morbidity among Black and Latinx adults.

J Allergy Clin Immunol 2022 May 18. Epub 2022 May 18.

University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

Background: Asthma disproportionately affects African-American/Black (AA/B) and Hispanic/Latinx (H/L) patients and individuals with low socioeconomic status (SES), but the relationship between SES and asthma morbidity within these racial/ethnic groups is inadequately understood.

Objective: To determine the relationship between SES and asthma morbidity among AA/B and H/L adults with moderate-severe asthma using multi-domain SES frameworks and mediation analyses.

Methods: We analyzed enrollment data from the PREPARE randomized trial, evaluating inhaled corticosteroid supplementation to rescue therapy. Read More

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Impact of Icariin and its derivatives on inflammatory diseases and relevant signaling pathways.

Int Immunopharmacol 2022 May 18;108:108861. Epub 2022 May 18.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, PR China. Electronic address:

Herba Epimedii is a famous herb collected from China and Korea. It has been used for impotency, osteoporosis, and amnestic treatment for thousands of years. Icariin, a typical flavonoid compound isolated from Herba Epimedii, was reported as a potential anti-inflammatory drug. Read More

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Current and Emerging Strategies to Inhibit Type 2 Inflammation in Atopic Dermatitis.

Dermatol Ther (Heidelb) 2022 May 21. Epub 2022 May 21.

Sanofi, 450 Water Street, Cambridge, MA, USA.

Type 2 immunity evolved to combat helminth infections by orchestrating a combined protective response of innate and adaptive immune cells and promotion of parasitic worm destruction or expulsion, wound repair, and barrier function. Aberrant type 2 immune responses are associated with allergic conditions characterized by chronic tissue inflammation, including atopic dermatitis (AD) and asthma. Signature cytokines of type 2 immunity include interleukin (IL)-4, IL-5, IL-9, IL-13, and IL-31, mainly secreted from immune cells, as well as IL-25, IL-33, and thymic stromal lymphopoietin, mainly secreted from tissue cells, particularly epithelial cells. Read More

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Nuclear receptor Nr1d1 alleviates asthma by abating GATA3 gene expression and Th2 cell differentiation.

Cell Mol Life Sci 2022 May 21;79(6):308. Epub 2022 May 21.

Department of Molecular Immunology, Council of Scientific and Industrial Research, Institute of Microbial Technology, Sector 39A, Chandigarh, 160036, India.

Nuclear receptors are a unique family of transcription factors that play cardinal roles in physiology and plethora of human diseases. The adopted orphan nuclear receptor Nr1d1 is a constitutive transcriptional repressor known to modulate several biological processes. In this study, we found that Nr1d1 plays a decisive role in T helper (Th)-cell polarization and transcriptionally impedes the formation of Th2 cells by directly binding to the promoter region of GATA binding protein 3 (GATA3) gene. Read More

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A Nurse Led Asthma Care Team transitioning patients from hospital to home improves asthma control: a pilot study exploring an alternative model of care.

Health Promot J Austr 2022 May 20. Epub 2022 May 20.

Department of Respiratory Medicine, Western Health, Melbourne, VIC, Australia.

Introduction: Recurrent asthma admissions are frequent in our patients at a tertiary Australian hospital, and commonly related to poor health literacy and medication adherence. A need exists to improve these asthma self-management skills within our current model of care, especially during the vulnerable post discharge period.

Aim: To examine if the addition of a nurse led Asthma Care Transition Team (ACTT) compared with usual care alone (UC) (1)improves asthma control at 12 weeks post hospital discharge; (2) the number of patients using a Written Action Plan (WAP), compliance with inhaler therapy at 12 weeks, and readmission rates at 6 months. Read More

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Alpha-1 Asthma Overlap Syndrome: a Clinical Overview.

Curr Allergy Asthma Rep 2022 May 20. Epub 2022 May 20.

Department of Internal Medicine, Section On Pulmonary, Critical Care, Immunologic, and Asthma Medicine, Wake Forest Baptist Hospital, 1 Medical Center Blvd, Winston-Salem, NC, 27157, USA.

Purpose Of Review: Alpha-1 antitrypsin deficiency (AATD) is one of the most common genetic diseases that is associated with severe complications and yet remains underdiagnosed. The pulmonary symptoms of both AATD and asthma include cough, excessive sputum production, dyspnea, and wheezing. These symptoms overlap significantly leading to difficulty distinguishing between these two conditions and suspicion that there may be an overlap syndrome. Read More

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Impacts of particulate matter (PM) on the health status of outdoor workers: observational evidence from Malaysia.

Environ Sci Pollut Res Int 2022 May 20. Epub 2022 May 20.

Faculty of Medicine and Health Sciences, UCSI University, 56000, Kuala Lumpur, Malaysia.

Ambient air pollution is a significant contributor to disease burden, leading to an estimated 4.2 million premature deaths and 103.1 million disability-adjusted life years (DALYs) annually worldwide. Read More

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Adaptation of the Quality of Communication Questionnaire for Family Members and Its Validity Evidence for Use in Brazil.

Am J Hosp Palliat Care 2022 May 20:10499091221102583. Epub 2022 May 20.

Pediatrics Department and in the Medical Science Postgraduation Program, Federal University of Santa Catarina, Florianópolis, Brazil.

Assessment of communication between physicians and patients' family members is essential to improving healthcare quality. To adapt the Quality of Communication Questionnaire (QoC) for family members and to analyze its validity evidence for use in Brazil. Data were collected between 2017 and 2019, with family members of patients in intensive care (IC) and palliative care (PC) from five public hospitals in the South Brazil. Read More

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Leukotriene-receptor antagonist and risk of neuropsychiatric events in children, adolescents, and young adults: a self-controlled case series.

Eur Respir J 2022 May 20. Epub 2022 May 20.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea

Leukotriene receptor antagonists (LTRAs) are widely used for asthma and allergic rhinitis (AR), but concerns about the risk of neuropsychiatric events (NPEs) have been raised since the first Drug Safety Communication by the US Food and Drug Administration in 2008. This study evaluates the association between LTRA and NPEs in children, adolescents, and young adults with asthma or AR.A self-controlled case series study was conducted using the Korean National Health Insurance Service claims database from two three-year observation periods (observation period 1 [Obs1]: 2005 to 2007, observation period 2 [Obs2]: 2016 to 2018). Read More

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IgA memory B cells are significantly increased in patients with asthma and small airways dysfunction.

Eur Respir J 2022 May 20. Epub 2022 May 20.

Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany

Background: Comprehensive studies investigated the role of T cells in asthma leading to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B cells to this chronic inflammatory disease. In this study, we investigated the contribution of various B cell populations to specific clinical features in asthma. Read More

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Cumulative Corticosteroid Sparing Effect of Anti-Interleukin-5/5Ra In Eosinophilic Asthma.

Eur Respir J 2022 May 20. Epub 2022 May 20.

Department of Pulmonology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.

Introduction: Anti-interleukin-5/5Ra therapy has shown to reduce maintenance oral corticosteroid dose in severe eosinophilic asthma. However, the effect on cumulative oral corticosteroid exposure is currently unknown. Neither is it known how prior oral corticosteroid exposure affects response to anti-interleukin-5/5Ra treatment. Read More

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Multiancestral polygenic risk score for pediatric asthma.

J Allergy Clin Immunol 2022 May 17. Epub 2022 May 17.

Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45229; Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229. Electronic address:

Background: Asthma is the most common chronic condition in children and the third leading cause of hospitalization in pediatrics. The genome-wide association study catalog reports 140 studies with genome wide significance. A polygenic risk score (PRS) with predictive value across ancestries has not been evaluated for this important trait. Read More

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Antibody Response to Graded Dosing of COVID-19 mRNA Vaccines After Allergic Reaction to First Dose.

Ann Allergy Asthma Immunol 2022 May 17. Epub 2022 May 17.

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh PA, USA. Electronic address:

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Comorbidities in Childhood-onset and Adult-Onset Asthma.

Ann Allergy Asthma Immunol 2022 May 17. Epub 2022 May 17.

Division of Asthma Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.

Background: Age of asthma onset has emerged as an important determinant of asthma phenotypes; however, the comorbidities that predominate in either childhood- or adult-onset asthma are unknown.

Objective: To identify comorbidities associated with adult-onset versus childhood-onset asthma and with age of asthma diagnosis.

Methods: We analyzed data on 27,437 adult participants to the National Health and Nutrition Examination Surveys conducted from 2001 to 2018. Read More

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Cyclin D1 expression and molecular genetic findings in periocular histiocytoses and neoplasms of macrophage-dendritic cell lineage.

Am J Ophthalmol 2022 May 17. Epub 2022 May 17.

Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: Frequent activating mutations in the mitogen-activated protein kinase (MAPK) pathway genes have been identified in histiocytoses. MAPK signaling consistently upregulates Cyclin D1. The goal of this study was to determine whether Cyclin D1 expression by immunohistochemistry is a useful diagnostic marker for periocular histiocytoses and to further characterize their genetic basis. Read More

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Air pollution, bronchiolitis, and asthma: the role of nasal microRNAs.

Lancet Respir Med 2022 May 17. Epub 2022 May 17.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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A short prokaryotic Argonaute activates membrane effector to confer antiviral defense.

Cell Host Microbe 2022 May 10. Epub 2022 May 10.

State Key Laboratory of Agricultural Microbiology and College of Life Sciences and Technology, Huazhong Agricultural University, 430070 Wuhan, China; Hubei Hongshan Laboratory, 430070 Wuhan, China. Electronic address:

Argonaute (Ago) proteins are widespread nucleic-acid-guided enzymes that recognize targets through complementary base pairing. Although, in eukaryotes, Agos are involved in RNA silencing, the functions of prokaryotic Agos (pAgos) remain largely unknown. In particular, a clade of truncated and catalytically inactive pAgos (short pAgos) lacks characterization. Read More

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Association of baseline parameters with year 0 and year 1 acute exacerbations in male patients with chronic obstructive pulmonary disease.

Int J Immunopathol Pharmacol 2022 Jan-Dec;36:3946320221099073

Department of Internal Medicine, 63328Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan.

Objectives: Acute exacerbations (AEs) of chronic obstructive pulmonary disease (COPD) can affect health status, hospitalization and readmission rates, and disease progression. This study aimed to identify independent markers associated with COPD AEs.

Methods: This study included male patients with COPD and collected data regarding their AEs and baseline clinical parameters. Read More

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Identifying asthma patients at high risk of exacerbation in a routine visit: A machine learning model.

Respir Med 2022 May 9;198:106866. Epub 2022 May 9.

Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada; Research Center, Hôpital Du Sacré-Coeur de Montréal, Montréal, Québec, Canada. Electronic address:

Background: Tools capable of predicting the risk of asthma exacerbations can facilitate asthma management in clinical practice. However, existing tools require additional data from patients beyond electronic medical records.

Objective: To predict asthma exacerbation in an upcoming year using electronically accessible data conditional on past adherence to asthma medications. Read More

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Early-life infection of the airways with Streptococcus pneumoniae exacerbates HDM-induced asthma in a murine model.

Cell Immunol 2022 May 14;376:104536. Epub 2022 May 14.

Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. Electronic address:

Respiratory tract infection early in life plays a significant role in the pathogenesis of asthma. In the present study we examine, using a murine surrogate, the effects of early life respiratory infection with Streptococcus pneumoniae (SP) on adult asthma induced by sensitisation and exposure to house dust mite (HDM) allergen. Mice (one week old) were infected with SP, then 3 weeks later sensitised to HDM emulsified with Al (OH)3 intraperitoneally and challenged intranasally with same allergen for up to a further 5 weeks to establish the asthma surrogate. Read More

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Development and Feasibility of a Mobile Asthma App for Children and Their Caregivers: Mixed Methods Study.

JMIR Form Res 2022 May 20;6(5):e34509. Epub 2022 May 20.

Allergy Center, National Center for Child Health and Development, Setagaya, Japan.

Background: Mobile health apps can support the self-management of pediatric asthma. Previous studies on mobile apps for children aged >7 years with asthma are limited, and most reports on asthma apps do not consider interactions between the children and their caregivers. Therefore, we developed an asthma app for children aged 0-12 years and their caregivers based on the results of our previous study regarding user needs. Read More

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Pediatr Pulmonol 2022 May 20. Epub 2022 May 20.

Orthopedics, First Pediatric Consultative Clinic - Sofia, Sofia, Bulgaria.

This article is protected by copyright. All rights reserved. Read More

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