197,455 results match your criteria Asthma


Eosinophilic vasculitis associated with persistent dupilumab-induced hypereosinophilia in severe asthma.

Respir Med Res 2021 Apr 28;79:100821. Epub 2021 Apr 28.

Groupe Hospitalier Universitaire AP-HP Nord-Université de Paris, Hôpital Bichat, Service de Pneumologie et Centre de Référence constitutif des Maladies Pulmonaires Rares; Inserm UMR 1152, Paris, France. Electronic address:

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Hybrids between HS-donors and betamethasone 17-valerate or triamcinolone acetonide inhibit mast cell degranulation and promote hyperpolarization of bronchial smooth muscle cells.

Eur J Med Chem 2021 May 5;221:113517. Epub 2021 May 5.

Department of Pharmacy, University of Naples «Federico II», Via D. Montesano 49, Naples, Italy. Electronic address:

Glucocorticoids represent the standard gold treatment of inflammation in asthmatic patients. More recently, HS has been described to exert positive effect on this disease. Bearing in mind that an improved pharmacological activity and a reduced toxicity can be obtained through hybridization of different molecules, simultaneously modulating multiple targets, we designed and synthesized novel betamethasone 17-valerate and triamcinolone acetonide hybrids with well-known HS-donor moieties. Read More

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Ethnopharmacology, biological activities and chemical compounds of Canarium strictum: An important resin-yielding medicinal tree in India.

Fitoterapia 2021 May 10:104920. Epub 2021 May 10.

Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, P.O. Box 1068, 0316 Oslo, Norway. Electronic address:

The resin of Canarium strictum Roxb. is used for rheumatism and asthma; the bark is used as a mosquito repellent. The major compounds in the resin are triterpenoids, but as no studies have been performed on the bark, this study investigated this economically important resource. Read More

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Asthma severity as a contributing factor to cancer incidence: A cohort study.

PLoS One 2021 13;16(5):e0250430. Epub 2021 May 13.

Mohammed bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Background: A putative link between asthma and asthma severity with the occurrence of cancer has been suggested but has not been fully investigated. The objective of this study is to assess the incidence of all types of cancer in a cohort of asthmatic patients.

Methods And Findings: A single center cohort retrospective study was conducted to investigate the role of asthma as a potential risk factor for various cancers. Read More

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Is there any association between asthma and Kawasaki disease? A systematic review and meta-analysis.

Pediatr Pulmonol 2021 May 13. Epub 2021 May 13.

Department of Respiratory, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Shandong University, Jinan, China.

Objective: Shared immune factors are involved in the pathogenesis of asthma and Kawasaki disease (KD). Consequently, several observational studies have explored an association between KD and asthma. This systematic review and meta-analysis aimed to explore the association between KD and asthma. Read More

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Air pollution and hospitalization in megacities: empirical evidence from Pakistan.

Environ Sci Pollut Res Int 2021 May 13. Epub 2021 May 13.

Remote Sensing, GIS and Climatic Research Lab (National Center of GIS and Space Applications), Centre for Remote Sensing, University of the Punjab, Lahore, Pakistan.

Air pollution has become a threat to human health in urban settlements, ultimately leading to negative impacts on overall economic system as well. Already developed nations and still developing countries both are at the risk of air pollution globally. In this scenario, this work aims to investigate the associations of asthma (AS) and acute upper respiratory infection (ARI) patients with satellite-based aerosol optical depth (AOD) and meteorological factors, i. Read More

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"Health outcomes in COPD smokers using heated tobacco products: a 3‑year follow‑up: comment".

Intern Emerg Med 2021 May 13. Epub 2021 May 13.

Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland.

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Inhaler technique in asthma and COPD: challenges and unmet knowledge that can contribute to suboptimal use in real life.

Authors:
Andrea S Melani

Expert Rev Clin Pharmacol 2021 May 13. Epub 2021 May 13.

Dipartimento Scienze Mediche, Policlinico Le Scotte, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

: Inhalers are the most commonly used devices for lung drug delivery in asthma and COPD. Inhaler use offers several advantages but requires the user's proper mastery. The issue of inhaler technique is very important as inhaler misuse remains common in real life regardless of the inhaler used and is associated with poor disease control. Read More

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Silencing a disintegrin and metalloproteinase‑33 attenuates the proliferation of vascular smooth muscle cells via PI3K/AKT pathway: Implications in the pathogenesis of airway vascular remodeling.

Mol Med Rep 2021 Jul 13;24(1). Epub 2021 May 13.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Respiratory Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, P.R. China.

Accumulating evidence suggests that pulmonary expression of a disintegrin and metalloproteinase‑33 (ADAM33) serves a key role in the pathogenesis of airway remodeling‑related diseases, including asthma. Airway vascular proliferation has been recognized as a key feature of airway remodeling. Our previous study showed that ADAM33 is constitutively expressed in airway vascular smooth muscle cells in patients with asthma, suggesting a potential role of ADAM33 in regulating airway vascular remodeling. Read More

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3,4,5‑Trihydroxycinnamic acid exerts anti‑inflammatory effects on TNF‑α/IFN‑γ‑stimulated HaCaT cells.

Mol Med Rep 2021 Jul 13;24(1). Epub 2021 May 13.

Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk‑do 28116, Republic of Korea.

3,4,5‑Trihydroxycinnamic acid (THCA) exhibits anti‑inflammatory activity in acute or chronic inflammatory disorders, such as acute lung injury and asthma. The present study investigated the anti‑inflammatory activity of THCA in a tumor necrosis factor‑α/interferon‑γ (TI) mixture‑stimulated human keratinocyte cell line. The results of ELISA and reverse transcription‑quantitative PCR revealed that THCA reduced the secretion and mRNA expression levels of interleukin (IL)‑6; IL‑8; thymus and activation‑regulated chemokine; macrophage‑derived chemokine; regulated upon activation, normal T cell expressed and secreted; and monocyte chemoattractant protein‑1 in TI mixture‑stimulated HaCaT cells. Read More

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The management of chronic rhinosinusitis in clinical practice: An International Survey.

J Biol Regul Homeost Agents 2021 Jan-Feb;35(1 Suppl. 2):45-50

Consultant allergist, Casa di Cura Villa Montallegro, Genoa, Italy.

Chronic rhinosinusitis (CRS) is a common disease and is currently classified in two main phenotypes: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). A panel of international experts conducted the present survey. A questionnaire, containing 25 questions, was completed by each member of the panel. Read More

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Sleep-disordered breathing in the otorhinolaryngological practice.

J Biol Regul Homeost Agents 2021 Jan-Feb;35(1 Suppl. 2):27-32

Consultant allergist, Casa di Cura Villa Montallegro, Genoa, Italy.

Sleep-disordered breathing (SDB) is a common disorder in childhood. Snoring and obstructive sleep apnea represents a demanding challenge for both paediatricians and otolaryngologists. This real-life study investigated the association of demographic and clinical factors on snoring and sleep apnea in children consecutively visited. Read More

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The preferences of people with asthma or chronic obstructive pulmonary disease for self-management support: A qualitative descriptive study.

J Clin Nurs 2021 May 12. Epub 2021 May 12.

School of Nursing & Midwifery, University College Cork, Cork, Ireland.

Aims And Objectives: The aim of this study was to explore and describe the self-management support (SMS) preferences of adults with asthma and/or chronic obstructive pulmonary disease (COPD).

Background: Self-management support interventions have had beneficial outcomes for people with asthma and people with COPD, though challenges remain in their implementation. Increased understanding of the support preferences of people with asthma/COPD can help inform the development of future interventions to address patients' preferences. Read More

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News & Views: Groundbreaking Discoveries in Immunology The Epithelial Barrier Hypothesis: a 20-year journey.

Allergy 2021 May 12. Epub 2021 May 12.

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

The global environment has been transformed rapidly in the last six decades as a direct result of a more westernized, industrialized, and modernized world. At the same time, humanity has faced a marked increase in allergic, autoimmune, metabolicand certain neuropsychiatricdiseases, especially in industrialized countries. Read More

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Pleiotropic associations of heterozygosity for the Z allele in the UK Biobank.

ERJ Open Res 2021 Apr 10;7(2). Epub 2021 May 10.

Division of Respiratory Medicine, University of Nottingham, and NIHR Nottingham BRC, NUH NHS Trust, Nottingham, UK.

Homozygosity for the Z allele causes α-antitrypsin deficiency, a rare condition that can cause lung and liver disease. However, the effects of Z allele heterozygosity on nonrespiratory phenotypes, and on lung function in the general population, remain unclear. We conducted a large, population-based study to determine Z allele effects on >2400 phenotypes in the UK Biobank (N=303 353). Read More

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Contribution of Satellite-Derived Aerosol Optical Depth PM Bayesian Concentration Surfaces to Respiratory-Cardiovascular Chronic Disease Hospitalizations in Baltimore, Maryland.

Atmosphere (Basel) 2020 18;11(2):209. Epub 2020 Feb 18.

I. M. Systems Group, 5825 University Research Ct, Suite 3250, College Park, MD 20740, USA.

The fine particulate matter baseline (PMB), which includes PM monitor readings with Community Multiscale Air Quality (CMAQ) model predictions, using the Hierarchical Bayesian Model (HBM), is less accurate in rural areas without monitors. To address this issue, an upgraded HBM was used to form four experimental aerosol optical depth (AOD)-PM concentration surfaces. A case-crossover design and conditional logistic regression evaluated the contribution of the AOD-PM surfaces and PMB to four respiratory-cardiovascular hospital events in all 99 12 km CMAQ grids, and in grids with and without ambient air monitors. Read More

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February 2020

Food Sublingual Immunotherapy Using Consistent, Cheaper and Customizable Oral Immunotherapy Solutions.

J Asthma Allergy 2021 5;14:467-470. Epub 2021 May 5.

Allergy and Asthma Medical Group of the Bay Area, Walnut Creek, CA, 94598, USA.

Food SLIT (sublingual immunotherapy) is a food desensitization method with a daily maintenance dose of <10 mg for up to 5 years. Many protocols use commercially available skin test extracts. Oral immunotherapy (OIT) treatment solutions have consistent protein concentrations, are comparatively cheaper and customizable and therefore were adapted for use in a published SLIT dosing schedule. Read More

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Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review.

Biologics 2021 5;15:133-142. Epub 2021 May 5.

Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Severe uncontrolled asthma is a complex and heterogeneous disease. A multidisciplinary assessment is required to correctly identify and manage children and adolescents with severe asthma because they may require strict monitoring and additional treatment with advanced targeted therapies. Recent research efforts have focused on identifying epidemiologic, clinical, and molecular mechanisms that underlie severe asthma, leading to the recognition of different phenotypes and endotypes and identifying biomarkers able to predict the response to biologic therapies. Read More

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Evaluation of anaphylaxis recurrence and adrenaline autoinjector use in childhood.

Allergy Asthma Proc 2021 May;42(3):e96-e100

Department of Pediatric Allergy and Immunology, University of Health Science Ankara City Hospital, Ankara, Turkey.

Limited data are available on recurrent anaphylaxis in childhood. Delayed adrenaline administration is the major cause of deaths due to anaphylaxis. As well as prescribing the adrenaline autoinjector (AAI), it is important to make sure that the patient carries the device at all times and uses it correctly for the appropriate indication. Read More

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Clinical phenotypes of childhood food allergies based on immune mechanisms: A multicenter study.

Allergy Asthma Proc 2021 May;42(3):e86-e95

The affiliations of the members of the writing committee and the names of all the authors are provided in the online appendix.

Food allergies (FA) are an important public health concern that place a major burden on the lives of children and their families. The complex pathogenesis of FAs results in multisystemic and heterogenous clinical presentations. To evaluate, according to immune mechanisms, the characteristics and risk factors of childhood FA in Turkey. Read More

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Patients' and physicians' attitudes and perception about asthma in the Gulf: A subset analysis from the Asthma Insights and Management Survey in the Gulf and Russia.

Allergy Asthma Proc 2021 May;42(3):e77-e85

Global Medical and Scientific Affairs, Merck & Co., Inc., Kenilworth, New Jersey.

Asthma is a prevalent disorder in the Gulf region. However, available data concerning asthma control and patients' perception with regard to their disease are still insufficient. To investigate patients' perception and behavior with regard to the asthma-related burden, the level of asthma control, and asthma management in three Gulf countries. Read More

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Association between elevated serum triglycerides and asthma in patients with obesity: An explorative study.

Allergy Asthma Proc 2021 May;42(3):e71-e76

From the Department of Pulmonology, Franciscus Gasthuis en Vlietland, Rotterdam, the Netherlands.

Adults with a high body mass index (BMI) have an increased risk of developing asthma. To explore the impact of increased lipids on the presence of asthma, this study investigated the relationship between lipid levels and inflammatory markers in patients with asthma and controls with obesity. We hypothesized that higher lipid levels are more prevalent in patients with obesity and asthma. Read More

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Studies of mitochondrial and nuclear DNA released from food allergen-activated neutrophils. Implications for non-IgE food allergy.

Allergy Asthma Proc 2021 May;42(3):e59-e70

Department of Pediatrics and Microbiology-Immunology, Georgetown University Medical Center, Washington, D.C., (USA); and.

Although adverse food reactions are commonly divided into immunoglobulin E (IgE) mediated food allergy (FA), and non-IgE FA, the current literature is providing support for the role of innate immune responses as an important component of non-IgE FA. Using a commercially available leukocyte activation (LA) assay, a recent quantitative study of total extracellular DNA released in cellular supernatants of human peripheral blood mononuclear cells exposed either to positive or negative tested foods demonstrated that leukocytes exposed to foods with positive LA test results showed higher DNA content than those exposed to foods with negative LA test results. In humans, the origin of DNA might be either the nucleus or the mitochondria. Read More

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For the patient.

Authors:

Allergy Asthma Proc 2021 May;42(3):260

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Emergency department revisits and rehospitalizations among infants and toddlers for acute allergic reactions.

Allergy Asthma Proc 2021 May;42(3):247-256

From the Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Allergic reactions, including anaphylaxis, are rising among children. Little is known about health care utilization among infants and toddlers. Our objective was to characterize health care utilization and charges for acute allergic reactions (AAR). Read More

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The relationship between mast cell activation syndrome, postural tachycardia syndrome, and Ehlers-Danlos syndrome.

Allergy Asthma Proc 2021 May;42(3):243-246

From the Tufts University School of Medicine, Boston, Massachusetts and.

Postural tachycardia syndrome (POTS), hypermobile Ehlers-Danlos syndrome (EDS), and mast cell activation syndrome (MCAS) can occur in the same patient. In this study, we investigated the relationship among these three syndromes. To establish the relationship of MCAS in patients diagnosed with POTS and hypermobile EDS as well as characterize the demographics of the patients affected by these syndromes. Read More

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Long-term efficacy and safety of omalizumab in patients with allergic asthma: A real-life study.

Allergy Asthma Proc 2021 May;42(3):235-242

From the 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens, 2nd Respiratory Medicine Department, "Attikon" University Hospital, Chaidari, Athens, Greece.

The efficacy and safety of omalizumab in patients with severe allergic asthma have been established in both randomized controlled trials and real-life studies. To evaluate the sustained effectiveness and safety of long-term treatment with omalizumab in a real-world setting. In this retrospective study, we included patients treated with omalizumab for at least 8 years in four asthma clinics in Greece. Read More

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