5,629 results match your criteria Assisted Reproduction Technology


Breakthroughs and new horizons in reproductive biology of rare and endangered animal species.

Biol Reprod 2019 Feb 17. Epub 2019 Feb 17.

Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield S10 2SF, UK.

Because of higher extinction rates due to human and natural factors, more basic and applied research in reproductive biology is required to preserve wild species and design proper strategies leading to sustainable populations. The objective of the review is to highlight recent, inspiring breakthroughs in wildlife reproduction science that will set directions for future research and lead to more successes in conservation biology. Despite new tools and approaches allowing a better and faster understanding of key mechanisms, we still know little about reproduction in endangered species. Read More

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http://dx.doi.org/10.1093/biolre/ioz031DOI Listing
February 2019

Hormonal medication in medically assisted reproduction: a systematic review of assessments from patients.

Reprod Biomed Online 2019 Jan 19. Epub 2019 Jan 19.

Centre for Reproductive Medicine, Women's and Children's Hospital, Academic Medical Centre, University of Amsterdam Amsterdam, the Netherlands; University of Leuven, Department of Development and Regeneration, Leuven, Belgium; University of Leuven, Department of Public Health and Primary Care, Leuven, Belgium; Research Foundation Flanders, Belgium. Electronic address:

Several hormonal fertility medications have comparable effectiveness. A literature review was conducted into patients' assessments regarding seven medication characteristics including 'side effects' and 'ease of use'. Medline, CINAHL and PsycINFO were searched for female fertility patients' written assessments of a hormonal medication. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.12.047DOI Listing
January 2019

Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart.

Cell Rep 2019 Feb;26(7):1934-1950.e5

Department of Obstetrics and Gynecology, Beijing Advanced Innovation Center for Genomics, College of Life Sciences, Third Hospital, Peking University, Beijing 100871, China; Biomedical Institute for Pioneering Investigation via Convergence, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Electronic address:

The heart is the central organ of the circulatory system, and its proper development is vital for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene expression landscapes of ∼4,000 cardiac cells from human embryos and identified four major types of cells: cardiomyocytes (CMs), cardiac fibroblasts, endothelial cells (ECs), and valvar interstitial cells (VICs). Atrial and ventricular CMs acquired distinct features early in heart development. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.079DOI Listing
February 2019

Three-dimensional printing models on reproductive surgery and human reproduction: systematic review and critical applications.

Minerva Ginecol 2019 Feb 12. Epub 2019 Feb 12.

Baby Center, Center for Reproductive Medicine, São Paulo, Brazil -

Background: 3D printing has wide application in medicine while it provides customizability and precision for anatomical model development. Our aims were to perform a systematic review and to explore the use of 3D printing applications on human reproduction and reproductive surgery.

Methods: We have performed a systematic review in PubMed database to assess previous publications within 3D printing in human reproduction and gynecology. Read More

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http://dx.doi.org/10.23736/S0026-4784.19.04319-3DOI Listing
February 2019

Transcriptome Analysis of Male and Female Mature Gonads of Silver Sillago ().

Genes (Basel) 2019 Feb 11;10(2). Epub 2019 Feb 11.

Guangdong Research Center on Reproductive Control and Breeding Technology of Indigenous Valuable Fish Species, Key Laboratory of Marine Ecology and Aquaculture Environment of Zhanjiang, Key Laboratory of Aquaculture in South China Sea for Aquatic Economic Animal of Guangdong Higher Education Institutes, Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China.

Silver sillago () is an emerging commercial marine aquaculture species in China. To date, fundamental information on , such as genomic information, is lacking, and no data are available on the gonad transcriptome of . Here, the first gonadal transcriptomes of have been constructed and genes potentially involved in gonadal development and reproduction identified. Read More

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http://dx.doi.org/10.3390/genes10020129DOI Listing
February 2019

Dietary Patterns and Outcomes of Assisted Reproduction.

Am J Obstet Gynecol 2019 Feb 8. Epub 2019 Feb 8.

Department of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115.

Background: There is growing acceptance that nutrition may be related to fertility, and specifically to ART success in women; however, there is still no specific dietary guidance.

Objective: To evaluate the relationship between pre-treatment adherence to various dietary patterns and outcomes of assisted reproductive technologies (ART).

Study Design: We followed 357 women enrolled in the prospective Environment and Reproductive Health (EARTH) Study, who underwent 608 ART cycles (2007-2017). Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.004DOI Listing
February 2019

Human Novel MicroRNA Seq-915_x4024 in Keratinocytes Contributes to Skin Regeneration by Suppressing Scar Formation.

Mol Ther Nucleic Acids 2019 Jan 10;14:410-423. Epub 2019 Jan 10.

Department of Stem Cells and Regenerative Medicine, Shenyang Key Laboratory for Stem Cells and Regenerative Medicine, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, 77 Puhe Street, Shenbei New District, Shenyang City 110122, Liaoning Province, China; Shenyang Amnion Bioengineering and Technology R & D Center, 155-5 Chuangxin Street, Hunnan District, Shenyang City 110015, Liaoning Province, China. Electronic address:

Early in gestation, wounds in fetal skin heal by regeneration, in which microRNAs play key roles. Seq-915_x4024 is a novel microRNA candidate confirmed by deep sequencing and mirTools 2.0. Read More

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http://dx.doi.org/10.1016/j.omtn.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365370PMC
January 2019
3 Reads

Intrafollicular melatonin concentration is elevated in patients with ovarian hyperstimulation syndrome (OHSS) and can serve as an important predictor of OHSS.

Arch Gynecol Obstet 2019 Feb 6. Epub 2019 Feb 6.

Center for Reproductive Medicine, School of Medicine, RenJi Hospital, Shanghai Jiao Tong University, Shanghai, 200135, China.

Purpose: Melatonin is an important factor in regulating numerous processes in human female reproduction. The aim of the present study was to compare melatonin levels in the follicular fluid (FF) of ovarian hyperstimulation syndrome (OHSS) women with those of non-OHSS women undergoing in vitro fertilization (IVF)-embryo transfer and to evaluate the relationship between FF melatonin levels and IVF outcomes in these women.

Methods: We determined FF melatonin levels in 20 OHSS women and 23 non-OHSS women on oocyte retrieval day. Read More

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http://dx.doi.org/10.1007/s00404-018-4994-zDOI Listing
February 2019

Queering reproduction in transnational bio-economies.

Authors:
Laura Mamo

Reprod Biomed Soc Online 2018 Nov 19;7:24-32. Epub 2018 Oct 19.

San Francisco State University, San Francisco, CA, USA.

In this commentary, I consider how scholars, practitioners and those seeking to have babies via assisted reproductive technology (ART) might be accountable to 21st century family-making in ways that attend to reproductive stratifications (the uneven support for people to conceive and raise children), and yet refuse to renaturalize or valorize certain forms of reproduction or reproduction by certain categories of persons [e.g. lesbian, gay, bisexual, transgender and gender queer (LGBTQ)/non-normative people]. Read More

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http://dx.doi.org/10.1016/j.rbms.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287057PMC
November 2018
1 Read

Specific detection of hypochlorite based on the size-selective effect of luminophore integrated MOF-801 synthesized by a one-pot strategy.

Dalton Trans 2019 Feb 5. Epub 2019 Feb 5.

Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

Hypochlorous acid (HClO), as one of the reactive oxygen species, plays a key role in a variety of physiological and pathological processes, while its accurate and specific in vitro monitoring remains a profound challenge. Herein, a novel luminescent metal-organic framework with high chemical stability has been designed for the specific detection of intracellular ClO-. The specificity was realized by the size-selective effect of MOF-801 with an ultra-small aperture, which can inhibit the entry of large-sized interferents into the cages of MOFs. Read More

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http://dx.doi.org/10.1039/c8dt04692aDOI Listing
February 2019

Goat membrane associated ring-CH-type finger 1 (MARCH1) mRNA expression and association with litter size.

Theriogenology 2019 Jan 19;128:8-16. Epub 2019 Jan 19.

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, PR China. Electronic address:

Membrane-associated ring-CH-type finger 1 (MARCH1), which mediates the ubiquitination of CD86 and MHC class II proteins, plays crucial roles in ruminant fecundity. To completely explore the functions of MARCH1 in goat reproduction, the mRNA expression of this gene were investigated in different tissues of goats. Moreover, we analyzed the association of three insertions and deletions (indels) within MARCH1 with litter size in a large population of Shaanbei white cashmere goats (n = 2844). Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.014DOI Listing
January 2019

Embryo transfer techniques.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 11. Epub 2019 Jan 11.

Assisted Reproductive Technology Unit, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. Electronic address:

Embryo transfer is the final and rate-limiting step of the assisted reproductive technique. Few advances have occurred in the last few decades with regard to this procedure. Studies conducted thus far have focused on factors and interventions taking place before, during and after this procedure. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.01.004DOI Listing
January 2019

Vitrification of murine mature metaphase II oocytes perturbs DNA methylation reprogramming during preimplantation embryo development.

Cryobiology 2019 Jan 29. Epub 2019 Jan 29.

Anhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China. Electronic address:

Accurate reprogramming of DNA methylation occurring in preimplantation embryos is critical for normal development of both fetus and placenta. Environmental stresses imposed on oocytes usually cause the abnormal DNA methylation reprogramming of early embryos. However, whether oocyte vitrification alters the reprogramming of DNA methylation (5 mC) and its derivatives in mouse preimplantation embryo development remains largely unknown. Read More

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http://dx.doi.org/10.1016/j.cryobiol.2019.01.012DOI Listing
January 2019
1.587 Impact Factor

Periconceptional environment and the developmental origins of disease.

J Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

A Watkins, Division of Child Health, Obstetrics and Gynaecology, Faculty of Medicine, University of Nottingham, Nottingham, United Kingdom of Great Britain and Northern Ireland.

The concept emerging from Professor David Barker's seminal research on the developmental origins of later life disease has progressed in many directions since first published. One critical question is when during gestation might environment alter the developmental programme with such enduring consequences. Here, we review the growing consensus from clinical and animal research that the period around conception, embracing gamete maturation and early embryogenesis, might be the most vulnerable period. Read More

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http://dx.doi.org/10.1530/JOE-18-0676DOI Listing
February 2019
1 Read

Ovarian Ectopic Pregnancy as IVF Complication: First Report in a Gestational Carrier.

Case Rep Obstet Gynecol 2018 31;2018:8190805. Epub 2018 Dec 31.

MyHealth Centre, London, ON, Canada.

Ovarian pregnancy is a rare subtype of ectopic pregnancy with an increased incidence after assisted conception. We present a 31-year-old gestational carrier who presented with suprapubic and pelvic pain at 6 weeks and 2 days' gestation. An ultrasound scan demonstrated an empty uterus and a complex mass in the left adnexa. Read More

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http://dx.doi.org/10.1155/2018/8190805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333000PMC
December 2018
1 Read

Introduction: Stimulate the mitochondria! A Bonington approach to improving assisted reproductive technology outcomes or a call to action?

Authors:
Richard S Legro

Fertil Steril 2019 Feb;111(2):195-196

Penn State College of Medicine, Hershey, Pennsylvania. Electronic address:

This introduction reviews the background of mitochondrial transplantation. Its goals are to provide both basic and clinical insights into mitochondria and reproduction. The articles will review the biology of mitochondria, mitochondrial DNA, mitochondrial dynamics, and mitochondrial stress (unfolded protein response), discuss novel imaging technology, fluorescent lifetime imaging microscopy to visualize mitochondria and their function in oocytes and early embryos, provide a critical and objective review of the data suggesting and refuting the possible use of mitochondrial DNA as well as other emerging technologies as a biomarker for embryo viability and finally to review the use of mitochondria as a rejuvenation tool in human in vitro fertilization. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.12.019DOI Listing
February 2019

Active surveillance of incidence and risk factors of hemolysis, elevated liver enzymes and low platelets syndrome in Slovakia.

Bratisl Lek Listy 2018 ;119(12):785-789

Objective: Hemolysis, Elevated Liver Enzymes, Low Platelets syndrome (HELLP syndrome) is one of the actively haunted maternal morbidity through Slovak Obstetric Survey System (SOSS), the organisation for surveillance of severe maternal morbidity and mortality in Slovakia.

Methods: The questionaires were sent in 55 Obstetric Units in Slovakia. The analyzed and here presented data had been collected cases those happened in the period from 1. Read More

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http://dx.doi.org/10.4149/BLL_2018_143DOI Listing
January 2018

Beliefs, attitudes and funding of assisted reproductive technology: Public perception of over 6,000 respondents from 6 European countries.

PLoS One 2019 25;14(1):e0211150. Epub 2019 Jan 25.

Theramex HQ UK Limited, London, United Kingdom.

Background: Fertility rates in Europe are among the lowest in the world, which may be attributed to both biological and lifestyle factors. Cost and reimbursement of fertility treatments vary across Europe, although its citizens enjoy wide access to fertility care. Since few regional studies evaluating public support for fertility treatment exist, we conducted the Listening IVF and Fertility in Europe (LIFE) survey to ascertain public perception of in vitro fertilization (IVF) and gamete donation as a treatment for infertility among European men and women. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211150PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347360PMC
January 2019
3 Reads

Current status of uterine regenerative medicine for absolute uterine factor infertility.

Biomed Rep 2019 Feb 4;10(2):79-86. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Though assisted reproduction technology has been developed, a treatment for absolute uterine factor infertility (AUFI), such as defects in the uterus, has not yet been established. Regenerative medicine has been developed and applied clinically over recent years; however, whole solid organs still cannot be produced. Though uterine regeneration has the potential to be a treatment for AUFI, there have been only a few studies on uterine regeneration involving the myometrium . Read More

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http://dx.doi.org/10.3892/br.2019.1182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341411PMC
February 2019

A quality management approach to controlled ovarian stimulation in assisted reproductive technology: the "Fischer protocol".

Panminerva Med 2019 Mar;61(1):11-23

Andrology and Human Reproduction Clinic, ANDROFERT, Campinas, Brazil.

Background: Ovarian stimulation (OS) is crucial for pregnancy success in assisted reproductive technology (ART) treatments. The possibility of programming the OS cycle and oocyte pick-up (OPU) is advantageous to Fertility Centers operating under quality management systems (QMS) as it might increase efficiency and safety. Moreover, cycle programming is patient-centered as it might help IVF patients to most optimally manage domestic and work commitments. Read More

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http://dx.doi.org/10.23736/S0031-0808.18.03549-8DOI Listing
March 2019
3 Reads

Female infertility and assisted reproductive technology.

Panminerva Med 2019 Mar;61(1):1-2

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.23736/S0031-0808.18.03553-XDOI Listing
March 2019
2.276 Impact Factor

The Roles of Mitochondrial SIRT4 in Cellular Metabolism.

Front Endocrinol (Lausanne) 2018 7;9:783. Epub 2019 Jan 7.

Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.

Sirtuins comprise a family of nicotinamide adenine dinucleotide (NAD)-dependent lysine deacylases that regulate the life span, aging, and metabolism. Seven sirtuin family members (SIRT1-7) have been identified in mammals, including humans. Despite the indispensable role of mitochondrial sirtuin 4 (SIRT4) in metabolic regulation, the primary enzymatic activity of SIRT4 remains enigmatic. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00783
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http://dx.doi.org/10.3389/fendo.2018.00783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330279PMC
January 2019
3 Reads

Problems of reproductive function in survivors of childhood- and adolescent and young adult-onset cancer revealed in a part of a national survey of Japan.

Reprod Med Biol 2019 Jan 20;18(1):105-110. Epub 2018 Nov 20.

Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki Japan.

Purpose: This study aimed to evaluate the current status of reproductive disorders as long-term complications in adolescent and young adult (AYA) cancer patients by comparing survivors of childhood-onset with those of AYA-onset cancer in Japan.

Methods: We conducted a national survey of AYA cancer survivors and healthy AYAs and analyzed the results from survivors who underwent chemotherapy and reported fertility problems as their current concern.

Results: Among all of the childhood-onset survivors, 27 (35. Read More

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http://dx.doi.org/10.1002/rmb2.12255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332776PMC
January 2019
2 Reads

Fertility preservation in adolescent and young adult cancer patients: From a part of a national survey on oncofertility in Japan.

Reprod Med Biol 2019 Jan 20;18(1):97-104. Epub 2018 Nov 20.

Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki Japan.

Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan.

Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Read More

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http://dx.doi.org/10.1002/rmb2.12256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332751PMC
January 2019
2 Reads

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation.

Hum Reprod Update 2019 Jan 11. Epub 2019 Jan 11.

Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Department of Obstetrics and Gynecology, Ministry of Education, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.

Background: Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include the secretion of gonadotropins, puberty onset, brain sex differentiation, ovulation and the metabolic regulation of fertility. Furthermore, recent studies have demonstrated the involvement of the kisspeptin system in the processes of implantation and placentation. Read More

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https://academic.oup.com/humupd/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/humupd/dmy046DOI Listing
January 2019
11 Reads

N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis.

J Cell Mol Med 2019 Mar 16;23(3):2163-2173. Epub 2019 Jan 16.

The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Institute of Urology of Shenzhen PKU-HKUST Medical Center, Shenzhen, P.R. China.

The abundant and reversible N6-methyladenosine (m6A) RNA modification and its modulators have important roles in regulating various gene expression and biological processes. Here, we demonstrate that fat mass and obesity associated (FTO), as an m6A demethylase, plays a critical anti-tumorigenic role in clear cell renal cell carcinoma (ccRCC). FTO is suppressed in ccRCC tissue. Read More

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http://dx.doi.org/10.1111/jcmm.14128DOI Listing
March 2019
4 Reads

Effect of preconceptional DHEA treatment on in vitro fertilization outcome in poor ovarian respond women: study protocol for a randomized controlled trial.

Trials 2019 Jan 15;20(1):50. Epub 2019 Jan 15.

Center for Reproductive Medicine, Key Laboratory of Reproductive Endocrinology, Ministry of Education, and National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong Provincial Clinical medicine Research Center for reproductive health, Shandong Provincial Hospital Affiliated with Shandong University, Shandong University, No. 157 Jing Liu Street, Shizhong district, Jinan, 250012, China.

Background: Women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with poor ovarian respond (POR) always have very low clinical pregnancy rates. In previous data, dehydroepiandrosterone (DHEA) was suggested as a promising treatment and maybe has a good pregnancy outcome. But there is no sufficient evidence from randomized clinical trials evaluating the effect of DHEA preconceptional treatment on live birth in POR. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-018-3146-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334415PMC
January 2019
8 Reads

Cryopreservation of human spermatozoa by vitrification versus conventional rapid freezing: Effects on motility, viability, morphology and cellular defects.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 5;234:14-20. Epub 2019 Jan 5.

Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Viet Nam; Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Viet Nam.

Objectives: Sperm cryopreservation has great potential for male infertility treatment as used in assisted reproduction technology (ART). There are a variety of cryopreservation methods in order to preserve sperm in a long term. Although conventional freezing and vitrification now are used widely, they have damage on sperm parameters as well as sperm DNA integrity. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.001DOI Listing
January 2019
4 Reads

Decreased chance of a live born child in women with rheumatoid arthritis after assisted reproduction treatment: a nationwide cohort study.

Ann Rheum Dis 2019 Mar 12;78(3):328-334. Epub 2019 Jan 12.

Department D, Centre of Andrology and Fertility Clinic, Odense University Hospital, Odense, Denmark.

Objectives: No studies have examined the efficacy of assisted reproductive technology (ART) treatment in women with rheumatoid arthritis. Therefore, we examined the chance of live birth after ART treatment in women with rheumatoid arthritis compared with women without rheumatoid arthritis.

Methods: Our cohort study is based on nationwide Danish health registries, comprising all women with an embryo transfer during 1 January 1994 through 30 June 2017. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21461
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http://dx.doi.org/10.1136/annrheumdis-2018-214619DOI Listing
March 2019
8 Reads

Derivation of Haploid Trophoblast Stem Cells via Conversion In Vitro.

iScience 2019 Jan 8;11:508-518. Epub 2019 Jan 8.

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China. Electronic address:

Owing to their single genome, haploid cells are powerful to uncover unknown genes by performing genetic screening in mammals. However, no haploid cell line from an extraembryonic lineage has been achieved yet, which limits the application of haploid cells in placental genetic screening. Here, we show that overexpression of Cdx2 can convert haploid embryonic stem cells to trophoblast stem cells (TSCs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25890042183024
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http://dx.doi.org/10.1016/j.isci.2018.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354440PMC
January 2019
6 Reads

Variation in the Promoter Region of the Gene Elucidates the Association of Body Measurement Traits in Hu Sheep.

Int J Mol Sci 2019 Jan 9;20(2). Epub 2019 Jan 9.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.

The () gene is expressed in the appetite-regulating areas of the brain and is engaged in the leptin signaling pathway. Although previous studies have identified variants in the coding region of the sheep gene showing significant associations with birth weight, weaning weight, and backfat thickness, no such associations have been reported for the promoter region. Besides, the essential promoter region of the sheep MC4R has not been delineated. Read More

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http://dx.doi.org/10.3390/ijms20020240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358852PMC
January 2019
1 Read

Multimodality imaging of acute locoregional and systemic complications in the setting of assisted reproduction.

Emerg Radiol 2019 Jan 10. Epub 2019 Jan 10.

Department of Radiology, Henry Ford Hospital, Detroit, MI, USA.

Over the past 40 years since the first in vitro fertilization was performed, both the role of assisted reproductive technology (ART) in establishing viable pregnancy as well as the available treatment options have expanded enormously. Annually in the USA, nearly 2% of pregnancies now employ some form of ART assistance, with in vitro fertilization (IVF) being the most commonly utilized methodology. Both maternal and fetal risks are elevated in ART pregnancies, the latter including adverse outcome due to both increased gestational number as well as advanced maternal age. Read More

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http://link.springer.com/10.1007/s10140-018-01665-w
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http://dx.doi.org/10.1007/s10140-018-01665-wDOI Listing
January 2019
6 Reads

Public perspectives on placing age limits on men and women seeking fertility treatment.

Fertil Steril 2019 Jan 2. Epub 2019 Jan 2.

Center for Infertility and Reproductive Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Objective: To assess public attitudes toward placing age limits on men and women seeking fertility treatment.

Design: Cross-sectional web-based survey.

Setting: Not applicable. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.11.019DOI Listing
January 2019
2 Reads

Classic congenital adrenal hyperplasia and its impact on reproduction.

Fertil Steril 2019 Jan;111(1):7-12

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Women with classic congenital adrenal hyperplasia (CAH) can suffer from impaired fertility rates as a result of increased androgen secretion or impaired sex steroid production. In virilizing CAH forms, such as 21-hydroxylase and 11β-hydroxylase deficiency, the low reported pregnancy rate is mainly secondary to a diminished desire to conceive. Optimal glucocorticoid and/or mineralocorticoid replacement, sufficient to normalize androgen and P levels in the follicular phase, allows natural conception in most cases. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.11.037DOI Listing
January 2019
2 Reads

Metabolic disturbances in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis.

Fertil Steril 2019 Jan;111(1):168-177

Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China; The Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, People's Republic of China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Jinan, People's Republic of China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China.

Objective: To explore metabolic disturbances in nonobese women with polycystic ovary syndrome (PCOS) compared with nonobese healthy controls.

Design: Systematic review and meta-analysis.

Setting: Not applicable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282183207
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http://dx.doi.org/10.1016/j.fertnstert.2018.09.013DOI Listing
January 2019
12 Reads

Melatonin alleviates the deterioration of oocytes from mice subjected to repeated superovulation.

J Cell Physiol 2019 Jan 4. Epub 2019 Jan 4.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bio Resources, Guangxi University, Nanning, Guangxi, China.

Induction of repeated superovulation with exogenous hormones is widely used in assisted reproductive technology (ART). Though it is generally safe, emerging evidence has indicated that repeated superovulation may compromise oocyte quality. However, few studies have explored how to ameliorate such impairment. Read More

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http://dx.doi.org/10.1002/jcp.28018DOI Listing
January 2019
1 Read

Factors inducing decreased oocyte maturation rate: a retrospective analysis of 20,939 ICSI cycles.

Arch Gynecol Obstet 2019 Jan 4. Epub 2019 Jan 4.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, No. 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.

Purpose: Decreased oocyte maturation rate (OMR) is associated with worse clinical outcomes in IVF/ICSI cycles. The clinical features inducing decreased OMR remain unknown. The study is designed to explore the factors influencing the incidence of decreased OMR and its effects on clinical outcomes. Read More

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http://dx.doi.org/10.1007/s00404-018-4958-3DOI Listing
January 2019
1.279 Impact Factor

Analysis of ambient temperature-responsive transcriptome in shoot apical meristem of heat-tolerant and heat-sensitive broccoli inbred lines during floral head formation.

BMC Plant Biol 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Life Sciences, National Cheng Kung University, No. 1, University Rd, Tainan City, 701, Taiwan.

Background: Head formation of broccoli (Brassica oleracea var. italica) is greatly reduced under high temperature (22 °C and 27 °C). Broccoli inbred lines that are capable of producing heads at high temperatures in summer are varieties that are unique to Taiwan. Read More

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https://bmcplantbiol.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12870-018-1613-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318969PMC
January 2019
6 Reads

Clinical significance and biological role of cancer-derived Type I collagen in lung and esophageal cancers.

Thorac Cancer 2019 Feb 3;10(2):277-288. Epub 2019 Jan 3.

State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Extracellular matrix (ECM) is remodeled during carcinogenesis. An abundant constituent of ECM is collagen. Type I collagen is secreted by fibroblasts, is important for tumor growth and epithelial-mesenchymal transition, and may also be secreted by cancer cells. Read More

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http://dx.doi.org/10.1111/1759-7714.12947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360244PMC
February 2019
1 Read

Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine model.

Biol Reprod 2018 Dec 28. Epub 2018 Dec 28.

Stem Cell Therapy Unit, Jesús Usón Minimally Invasive Surgery Centre (JUMISC), Cáceres, Spain.

Advanced age is a risk factor undermining women´s fertility. Hence, the optimization of assisted reproduction techniques is an interdisciplinary challenge that requires the improvement of in vitro culture systems. Here, we hypothesize that supplementation of embryo culture medium with extracellular vesicles from endometrial-derived mesenchymal stem cells (EV-endMSCs) may have a positive impact on the embryo competence of aged oocytes. Read More

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http://dx.doi.org/10.1093/biolre/ioy263DOI Listing
December 2018
3 Reads
3.318 Impact Factor

Dydrogesterone: pharmacological profile and mechanism of action as luteal phase support in assisted reproduction.

Reprod Biomed Online 2019 Feb 15;38(2):249-259. Epub 2018 Dec 15.

Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.

The pharmacological and physiological profiles of progestogens used for luteal phase support during assisted reproductive technology are likely to be important in guiding clinical choice towards the most appropriate treatment option. Various micronized progesterone formulations with differing pharmacological profiles have been investigated for several purposes. Dydrogesterone, a stereoisomer of progesterone, is available in an oral form with high oral bioavailability; it has been used to treat a variety of conditions related to progesterone deficiency since the 1960s and has recently been approved for luteal phase support as part of an assisted reproductive technology treatment. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.11.017DOI Listing
February 2019
4 Reads
3.015 Impact Factor

Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells-Potential Pathogenesis of Polycystic Ovary Syndrome.

Reprod Sci 2018 Dec 30:1933719118818899. Epub 2018 Dec 30.

1 Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Kisspeptins are a family of neuropeptides that are essential for fertility. Recent experimental data suggest a putative role of kisspeptin signaling in the direct control of ovarian function. To explore the expression of KISS1 and KISS1 receptor (KISS1R) in human granulosa lutein cells and the potential role of KISS1/KISS1R system in the pathogenesis of polycystic ovary syndrome (PCOS), we measured the concentration of KISS1 in follicular fluid, the expression of KISS1 and KISS1R in granulosa lutein cells, and the circulating hormones. Read More

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http://dx.doi.org/10.1177/1933719118818899DOI Listing
December 2018
5 Reads

The recessive C locus in the MITF gene plays a key regulatory role in the plumage colour pattern of duck (Anas platyrhynchos).

Br Poult Sci 2018 Dec 30:1-4. Epub 2018 Dec 30.

a Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education , Huazhong Agricultural University , Wuhan , Hubei Province , China.

1. The c/c alleles are responsible for the white plumage colour of ducks; however, the gene corresponding to this locus is still unclear. In order to identify the locus-related candidate gene associated with duck's plumage colour pattern, it was necessary to analyse the whole genome resequencing data. Read More

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http://dx.doi.org/10.1080/00071668.2018.1564237DOI Listing
December 2018
2 Reads

Whole-exome sequencing identified a novel mutation of AURKC in a Chinese family with macrozoospermia.

J Assist Reprod Genet 2018 Dec 29. Epub 2018 Dec 29.

Center for Reproductive Medicine, Anhui Provincial Hospital Affiliated to University of Science and Technology of China, Hefei City, Anhui Province, China.

Purpose: Macrozoospermia is a rare sperm morphologic abnormality associated with male infertility and is characterized by a high percentage of spermatozoa with large irregular heads. The aim of this study was to identify the genetic cause of an infertile male with macrozoospermia from a consanguineous family.

Methods: Whole-exome sequencing (WES) was performed using peripheral blood genomic DNA from the patient and his parents. Read More

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http://dx.doi.org/10.1007/s10815-018-1374-3DOI Listing
December 2018
1 Read

Sperm solute carrier family 9 regulator 1 is correlated with boar fertility.

Theriogenology 2019 Mar 15;126:254-260. Epub 2018 Dec 15.

Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do, 17546, Republic of Korea; BET Research Institute, Chung-Ang University, Anseong, Gyeonggi-do, 17546, Republic of Korea. Electronic address:

Predicting male fertility is extremely important for artificial insemination and profitable farm management. Conventional semen assessment together with computer-assisted sperm analysis is widely used to predict male fertility under field conditions. However, the clinical validation and sensitivity of these methods remain unclear. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2018.12.023DOI Listing
March 2019
1 Read
1.798 Impact Factor

Melatonin protects in vitro matured porcine oocytes from toxicity of Aflatoxin B1.

J Pineal Res 2018 Dec 25:e12543. Epub 2018 Dec 25.

Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Aflatoxin B1 (AFB1) is a major food and feed contaminant that threaten public health. Previous studies indicate that AFB1 exposure disrupted oocyte maturation. However, an effective and feasible method is unavailable for protecting oocytes against toxicity of AFB1. Read More

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http://dx.doi.org/10.1111/jpi.12543DOI Listing
December 2018
4 Reads
9.600 Impact Factor

Sperm Collection of Differential Quality Using Density Gradient Centrifugation.

J Vis Exp 2018 Nov 29(141). Epub 2018 Nov 29.

Department of Poultry Science, University of Georgia;

In sexual reproduction, a male gamete or sperm cell fuses with a female gamete to bring about fertilization. However, a large number of sperm cells with fertilizing ability are required to interact with a female gamete to ensure fertilization. As such, the fertilizing ability of individual sperm cells is critical for successful reproduction. Read More

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http://dx.doi.org/10.3791/58833DOI Listing
November 2018
2 Reads

Identification of programmed cell death 1 and its ligand in the testicular tissue of mice.

Am J Reprod Immunol 2018 Dec 22:e13079. Epub 2018 Dec 22.

Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Problem: This study aims to determine the expression and localization of programmed cell death 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) in the testes of mice at different developmental stages.

Method Of Study: By means of RT-qPCR, Western blot and immunofluorescence, the expression and localization of PD-1 and PD-L1 were detected in the testicular tissues of mice at different postnatal times: P7, P14, P21, P28, P35, and adulthood. Meanwhile, the level of soluble PD-L1 (sPD-L1) was evaluated by ELISA in the testicular interstitial fluid (IF) of the adult mice, culture supernatants of TM4 cell lines (Sertoli cells lines), and primary Sertoli cells at P14. Read More

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http://doi.wiley.com/10.1111/aji.13079
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http://dx.doi.org/10.1111/aji.13079DOI Listing
December 2018
7 Reads

Interaction of acrocentric chromosome involved in translocation and sex of the carrier influences the proportion of alternate segregation in autosomal reciprocal translocations.

Hum Reprod 2019 Feb;34(2):380-387

Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, 157 Jingliu Road, Jinan, China.

Study Question: Are meiotic segregation patterns of reciprocal translocations affected by the combined effect of chromosome type and carrier's sex?

Summary Answer: Interaction of an acrocentric chromosome (Acr-ch) involved in the translocation and sex of the carrier influences the proportion of alternate segregation for normal or balanced chromosome contents during meiotic segregation in autosomal reciprocal translocations.

What Is Known Already: Carriers of reciprocal translocations are at a significantly increased risk of fertility problems due to the generation of unbalanced gametes in meiotic segregation of a quadrivalent. Previous studies have reported that meiotic segregation patterns of a quadrivalent can be affected by factors such as a carrier's sex and age and the chromosome type. Read More

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http://dx.doi.org/10.1093/humrep/dey367DOI Listing
February 2019
2 Reads
4.569 Impact Factor