5,789 results match your criteria Assisted Reproduction Technology


Correlation between gross domestic product, utilization of in vitro fertilization and pregnancy success rate across the world.

J Med Econ 2019 Apr 23. Epub 2019 Apr 23.

c Department of Women and Children's Health , King's College London , UK.

IVF is now a wide spread procedure globally, and currently 65 countries report annually all or part of their IVF/ICSI cycles, from which the International Committee Monitoring progress in Assisted Reproduction Technology (ICMART) published its report. There is considerable variation in the utilisation (number of cycles per population) globally. The objectives of this study were to assess whether utilisation is related to national wealth, presented as gross domestic product (GDP) and whether the GDP has any effect on success in IVF treatment, mainly delivery and clinical pregnancy rates. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609484DOI Listing

DNA methylation analysis and editing in single mammalian oocytes.

Proc Natl Acad Sci U S A 2019 Apr 22. Epub 2019 Apr 22.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 200135 Shanghai, China;

Mammalian oocytes carry specific nongenetic information, including DNA methylation to the next generation, which is important for development and disease. However, evaluation and manipulation of specific methylation for both functional analysis and therapeutic purposes remains challenging. Here, we demonstrate evaluation of specific methylation in single oocytes from its sibling first polar body (PB1) and manipulation of specific methylation in single oocytes by microinjection-mediated dCas9-based targeted methylation editing. Read More

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http://dx.doi.org/10.1073/pnas.1817703116DOI Listing

CIDR estrous synchronization in the Arabian Oryx (Oryx leucoryx).

Theriogenology 2019 Apr 15;132:113-117. Epub 2019 Apr 15.

Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University, Saudi Arabia.

In Jordan, the Arabian Oryx (Oryx leucoryx) is considered among the most important wild ungulates. The Arabian Oryx is listed as vulnerable species according to the International Union for Conservation of Nature (IUCN). Based on author's knowledge, estrus synchronization in the Arabian Oryx has never been investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093691X193009
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http://dx.doi.org/10.1016/j.theriogenology.2019.04.017DOI Listing
April 2019
1 Read

High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration.

Biomed Pharmacother 2019 Apr 18;115:108867. Epub 2019 Apr 18.

Institute of Diagnostics, School of Medicine, Shandong University, Ji'nan, Shandong, China. Electronic address:

Homeobox-containing 1 (HMBOX1) has been reported to be associated with biological characteristics of some tumors, but its roles in gastric cancer have never been reported. In the present study, we found that HMBOX1 expression was significantly upregulated in gastric cancer tissues and cell lines and correlated with the TNM stage, lymph-node metastatic and the overall survival (OS) of patients of gastric cancer. The overexpression of HMBOX1 in gastric cancer cells enhanced cell proliferation by accelerating cell cycle, induced cell migration. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108867DOI Listing

Single embryo transfer: Why and how to identify the embryo with the best developmental potential.

Authors:
Aila Tiitinen

Best Pract Res Clin Endocrinol Metab 2019 Apr 13. Epub 2019 Apr 13.

Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, FI-00029 Helsinki, Finland. Electronic address:

Multiple pregnancies with higher risk of preterm birth and the associated higher morbidity have been a major obstacle from the early days of in vitro fertilization. A good strategy to avoid multiple pregnancies is elective single embryo transfer and cryopreservation of spare embryos. Important factors in adopting this strategy are good counselling of the patients and the selection of embryos with high implantation potential. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X193001
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http://dx.doi.org/10.1016/j.beem.2019.04.001DOI Listing
April 2019
1 Read

Health of adults aged 22 to 35 years conceived by assisted reproductive technology.

Fertil Steril 2019 Apr 9. Epub 2019 Apr 9.

Hudson Institute of Medical Research, Clayton, Victoria, Australia; Monash IVF Group Pty Ltd, Richmond, Victoria, Australia; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

Objective: To determine the health outcomes for adults aged 22-35 years old who were conceived via assisted reproduction technology (ART) compared with adults of the same age conceived without use of ART.

Design: Cohort study.

Setting: Not applicable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282193024
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http://dx.doi.org/10.1016/j.fertnstert.2019.03.001DOI Listing
April 2019
2 Reads

Prevalence of polycystic ovary syndrome in a metabolically healthy obese population.

Int J Gynaecol Obstet 2019 Apr 19. Epub 2019 Apr 19.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Objective: To determine whether polycystic ovary syndrome (PCOS) prevalence is increased among metabolically healthy obese (MHO) women.

Methods: A national epidemiologic survey in 10 provinces and municipalities of China between October 2007 and September 2011. Women were stratified into four groups according to metabolic health (Assessment by Adult Treatment Panel III) and obesity (body mass index [BMI] ≥28): metabolically healthy nonobese (MHNO), metabolically unhealthy nonobese (MUNO), MHO, and metabolically unhealthy obese (MUO). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.12824
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http://dx.doi.org/10.1002/ijgo.12824DOI Listing
April 2019
4 Reads

Mutational analysis of theFAM175A gene in patients with premature ovarian insufficiency.

Reprod Biomed Online 2019 Feb 28. Epub 2019 Feb 28.

Centre for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, China. Electronic address:

Research Question: The family with sequence similarity 175 member A gene (FAM175A; also known as ABRAXAS1, CCDC98 and ABRA1), a member of the DNA repair family, contributes to the BRCA1 (BRCA1 DNA repair associated)-dependent DNA damage response and is associated with age at natural menopause. However, it remains poorly understood whether sequence variants in FAM175A are causative for premature ovarian insufficiency (POI). The aim of this study was to investigate whether mutations in the gene FAM175A were present in patients with POI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14726483193010
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http://dx.doi.org/10.1016/j.rbmo.2019.02.006DOI Listing
February 2019
1 Read

Testicular sperm for intracytoplasmic sperm injection in non-azoospermic men: a paradigm shift.

Panminerva Med 2019 Jun;61(2):178-186

Andrology and Human Reproduction Clinic ANDROFERT, Campinas, Brazil -

In recent years, growing evidence has challenged the notion that sperm quantity and quality are not essential for the success of assisted reproductive technology. DNA fragmentation assessments on ejaculated and testicular sperm harvested from non-azoospermic infertile men have reported a remarkable decrease in DNA damage in spermatozoa directly retrieved from the seminiferous tubules. Moreover, emerging evidence using molecular genetic techniques indicates that aneuploidy rates are lower in testicular sperm than in ejaculated counterparts. Read More

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https://www.minervamedica.it/index2.php?show=R41Y2019N02A017
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http://dx.doi.org/10.23736/S0031-0808.18.03534-6DOI Listing
June 2019
3 Reads

Male infertility and assisted reproductive technology.

Panminerva Med 2019 Jun;61(2):101-103

Center for Reproductive Medicine ORIGEN, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.23736/S0031-0808.18.03586-3DOI Listing
June 2019
3 Reads
2.276 Impact Factor

Two indel variants of prolactin receptor (PRLR) gene are associated with growth traits in goat.

Anim Biotechnol 2019 Apr 15:1-10. Epub 2019 Apr 15.

a Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology , Northwest A&F University , Yangling , Shaanxi , People's Republic of China.

Prolactin receptor (PRLR) gene plays a crucial role in the milk production, reproduction and the growth of mammals. To fully characterize the structure of the mutation and to further study the function of the goat PRLR gene, two insertion/deletion (indel) loci (12 bp; 16-bp; 5-bp) were detected in 1038 Shaanbei white cashmere (SBWC) goats. Associated analysis revealed that the 16-bp indel mutation was significantly associated the body length, body height, chest depth (CD), body length index (BLI), heart girth index and cannon circumference index (CCI) (p < 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/10495398.2019.1
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http://dx.doi.org/10.1080/10495398.2019.1594863DOI Listing
April 2019
3 Reads

ART Registries-Characteristics and experiences: A comparative study.

J Family Med Prim Care 2019 Feb;8(2):449-454

Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Background: The incident of infertility is continuously increasing. As a result, the demand for medical care such as assisted reproductive technology (ART) technology is equally increasing. In order to manage the growing data and information collected on ART, there is a need for a registry system can provide accurate statistics about activities and outcomes and ensure the quality control. Read More

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http://www.jfmpc.com/text.asp?2019/8/2/449/253059
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http://dx.doi.org/10.4103/jfmpc.jfmpc_453_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436318PMC
February 2019
5 Reads

Fbxo30 regulates chromosome segregation of oocyte meiosis.

Cell Mol Life Sci 2019 Apr 12. Epub 2019 Apr 12.

Center for Reproductive Medicine, Peking University Third Hospital, Beijing, 100191, China.

As the female gamete, meiotic oocytes provide not only half of the genome but also almost all stores for fertilization and early embryonic development. Because de novo mRNA transcription is absent in oocyte meiosis, protein-level regulations, especially the ubiquitin proteasome system, are more crucial. As the largest family of ubiquitin E3 ligases, Skp1-Cullin-F-box complexes recognize their substrates via F-box proteins with substrate-selected specificity. Read More

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http://link.springer.com/10.1007/s00018-019-03038-z
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http://dx.doi.org/10.1007/s00018-019-03038-zDOI Listing
April 2019
3 Reads

Do quality improvements in assisted reproduction technology increase patient numbers in a managed competition setting?

Int J Health Plann Manage 2019 Apr 12. Epub 2019 Apr 12.

Radboud Institute for Health Sciences, IQ Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands.

In a system of managed competition, selective contracting and patient choice reward providers for quality improvements through increases in patient numbers and revenue. We research whether these mechanisms function as envisioned by investigating the relationship between quality improvements and patient numbers in assisted reproduction technology in the Netherlands. Success rate improvements primarily reduce volume as fewer secondary treatments are necessary, but this can be compensated by attracting new patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hpm.2778
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http://dx.doi.org/10.1002/hpm.2778DOI Listing
April 2019
3 Reads

Artificial intelligence in reproductive medicine.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

S Liao, Department of Obstetrics and Gynecology, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Artificial intelligence (AI) has experienced rapid growth over the past few years, moving from the experimental to the implementation phase in various fields, including medicine. Advances in learning algorithms and theories, the availability of large datasets, and improvements in computing power have contributed to breakthroughs in current AI applications. Machine learning (ML), a subset of AI, allows computers to detect patterns from large complex datasets automatically and uses these patterns to make predictions. Read More

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http://dx.doi.org/10.1530/REP-18-0523DOI Listing
April 2019
3 Reads

Mid-life fertility: Challenges & policy planning.

Authors:
Umesh N Jindal

Indian J Med Res 2018 Dec;148(Supplement):S15-S26

Department of Assisted Reproduction, Jindal IVF & Sant Memorial Nursing Home, Chandigarh, India.

This review highlights the challenges, priority areas of research and planning, strategies for regulation of services and the need to develop guidelines and laws for fertility treatments during mid-life. The success rate of all treatments is poor in advanced age women because of declining ovarian reserve and natural fertility. There is often a need of third-party involvement which has its own ethical, legal and medical issues. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_647_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469367PMC
December 2018
2 Reads

Infertility & assisted reproduction: A historical & modern scientific perspective.

Indian J Med Res 2018 Dec;148(Supplement):S10-S14

Department of Environmental Studies, Satyawati College, University of Delhi, Delhi, India.

Infertility has always been considered as a social stigma and has often been treated as socially, mentally and physically damaging experience for the childless women rather than man. Fatherhood was more a social rather than biological concept, thereby making childlessness a legitimate ground for divorce and a matter of disgrace for women. Every country has its own set of customs and traditional beliefs for the relief of childlessness. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_636_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469376PMC
December 2018
13 Reads

Successful treatment of one case of pemphigoid gestationis complicating with polycystic ovary syndrome.

Dermatol Ther 2019 Apr 8:e12898. Epub 2019 Apr 8.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Pemphigoid gestationis (PG) is a rare, autoimmune, subepidermal bullous dermatosis associated with pregnancy. It's mainly caused by autoantibodies against hemidesmosomal proteins - bullous pemphigoid 180, and usually presents in the second or third trimester of pregnancy sometimes exacerbates spontaneously after delivery. Here we reported a case of PG with polycystic ovary syndrome. Read More

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http://dx.doi.org/10.1111/dth.12898DOI Listing
April 2019
3 Reads
1.478 Impact Factor

Antioxidants and Male Fertility: from Molecular Studies to Clinical Evidence.

Antioxidants (Basel) 2019 Apr 5;8(4). Epub 2019 Apr 5.

Research Group of Intracellular Signaling and Technology of Reproduction (SINTREP), Institute of Biotechnology in Agriculture and Livestock (INBIO G+C), University of Extremadura, 10004 Cáceres, Spain.

Spermatozoa are physiologically exposed to reactive oxygen species (ROS) that play a pivotal role on several sperm functions through activation of different intracellular mechanisms involved in physiological functions such as sperm capacitation associated-events. However, ROS overproduction depletes sperm antioxidant system, which leads to a condition of oxidative stress (OS). Subfertile and infertile men are known to present higher amount of ROS in the reproductive tract which causes sperm DNA damage and results in lower fertility and pregnancy rates. Read More

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http://dx.doi.org/10.3390/antiox8040089DOI Listing
April 2019
5 Reads

Embryo Donation in New Zealand: Considerations of the Health and Wellbeing of Children.

Authors:
Louise Wilsdon

J Law Med 2019 Apr;26(3):691-701

Post-graduate student, University of Otago, New Zealand.

Embryo donation offers a potential solution to infertility for recipients of donated embryos, and also provides an alternative option for donors who do not wish to dispose of their surplus embryos after completing their own family through in vitro fertilisation. Embryo donation is an efficient and successful treatment for infertility, however the intentional division of social and genetic parenthood raises complex ethical issues. In New Zealand embryo donation for reproductive purposes comes under the remit of the Human Assisted Reproductive Technology Act 2004 (NZ) (HART Act). Read More

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April 2019
2 Reads

Live birth rate and neonatal outcome following cleavage-stage embryo transfer versus blastocyst transfer using the freeze-all strategy.

Reprod Biomed Online 2018 Dec 23. Epub 2018 Dec 23.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Zhizaoju Road No.639, Huangpu District, Shanghai 200011, People's Republic of China. Electronic address:

Research Question: What are the live birth rates and neonatal outcomes following cleavage-stage embryo transfer and blastocyst transfer in a freeze-all treatment scenario?

Design: This was a retrospective cohort study. All good-quality embryos were frozen on the third day; the remaining embryos were grown on until they reached blastocyst stage and then frozen. Between 2007 and 2016, 11,801 patients underwent cleavage-stage embryo transfer and 1009 patients underwent blastocyst transfer in the first treatment cycle using the freeze-all strategy. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.12.034DOI Listing
December 2018
3 Reads

Chemometrics-assisted optimization of liquid chromatography-quadrupole-time-of-flight mass spectrometry analysis for targeted metabolomics.

Talanta 2019 Jul 22;199:380-387. Epub 2019 Feb 22.

Institute of Agrochemistry and Food Technology (IATA-CSIC), Paterna, Valencia, Spain; Analytical Unit, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.

Mass spectrometry-based metabolomics is characterized by a vast number of variables leading to a great degree of complexity. In this work, we aimed to simplify this process with a stepped chemometric optimization of the both funnel technology (funnel exit DC, FDC; funnel RF LP, FLC; funnel RF HP, FRP) and ion source parameters (Octopolo, Oct; and Fragmentor, Frag) of a quadrupole-time of flight (qTOF) for a human urinary metabolites. The workflow comprised a Box-Behnken experimental design with 47 experiments followed by the identification and quantification of a set of metabolites using high-resolution full-scan MS mode and feature extraction with an inclusion list. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.02.075DOI Listing
July 2019
3 Reads

Effect of levothyroxine supplementation on pregnancy loss and preterm birth in women with subclinical hypothyroidism and thyroid autoimmunity: a systematic review and meta-analysis.

Hum Reprod Update 2019 May;25(3):344-361

Department of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical University, No. 295 Xi Chang road, Kunming, China.

Background: Subclinical hypothyroidism (SCH) and thyroid autoimmunity (TAI) are associated with adverse pregnancy outcomes such as pregnancy loss and preterm birth. However, the ability of levothyroxine (LT4) supplementation to attenuate the risks of these outcomes remains controversial.

Objective And Rationale: This systematic review and meta-analysis was conducted to determine the effect of LT4 supplementation on pregnancy loss rate (PLR) and preterm birth rate (PBR) among pregnant women with SCH and TAI. Read More

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http://dx.doi.org/10.1093/humupd/dmz003DOI Listing
May 2019
4 Reads

Brefeldin A impairs porcine oocyte meiotic maturation via interruption of organelle dynamics.

J Cell Physiol 2019 Apr 4. Epub 2019 Apr 4.

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.

Brefeldin A (BFA) is a lactone antibiotic synthesized from palmitic acid by several fungi that could block anterograde transport of proteins from endoplasmic reticulum to Golgi apparatus by reversible disruption of the Golgi complex. Previous investigations have shown that BFA induces the apoptosis of cancer cells in mitosis and impairs asymmetric spindle positioning in meiosis. Here, we document that exposure to BFA in porcine oocytes compromises the meiotic maturation via disrupting both nuclear and cytoplasmic maturation. Read More

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http://dx.doi.org/10.1002/jcp.28611DOI Listing
April 2019
2 Reads

SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.

Nucleic Acids Res 2019 Apr 5. Epub 2019 Apr 5.

Center for Reproductive Medicine, Shandong University, Jinan, China; The Key Laboratory of Reproductive Endocrinology of Ministry of Education, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.

Meiosis is a specialized cell division for producing haploid gametes from diploid germ cells. During meiosis, synaptonemal complex (SC) mediates the alignment of homologs and plays essential roles in homologous recombination and therefore in promoting accurate chromosome segregation. In this study, we have identified a novel protein SCRE (synaptonemal complex reinforcing element) as a key molecule in maintaining the integrity of SC during meiosis prophase I in mice. Read More

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http://dx.doi.org/10.1093/nar/gkz226DOI Listing
April 2019
2 Reads

Down-regulation of MicroRNA-592 in obesity contributes to hyperglycemia and insulin resistance.

EBioMedicine 2019 Apr 1. Epub 2019 Apr 1.

Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Background: Many studies have demonstrated that microRNAs, a class of small and non-coding RNA molecules, play an important role in the regulation of glucose and lipid homeostasis. In the present study, we sought to investigate the function of miR-592 in the development of obesity-associated metabolic disorders, including hyperglycemia andinsulin resistance.

Methods: The expression levels of miR-592 were measured in the liver of obese mice and humans by quantitative reverse transcription PCR. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.03.041DOI Listing
April 2019
9 Reads

Perspectives in Gamete and Embryo Cryopreservation.

Semin Reprod Med 2018 Sep 4;36(5):253-264. Epub 2019 Apr 4.

Cryopreserved gametes and embryos are a major feature of human-assisted reproduction and patient care services, accounting for an increasing number of births worldwide. Since the first success obtained using frozen human spermatozoa, cryopreservation technology has been successfully extended to include oocytes and embryos, in a variety of both medical and nonmedical indications. Over the years, the available procedures have become widely implemented and the increasing evidence of its efficacy has contributed to acceptance of the technology. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1677463
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http://dx.doi.org/10.1055/s-0038-1677463DOI Listing
September 2018
10 Reads

Complications of Assisted Reproductive Technology.

Emerg Med Clin North Am 2019 May;37(2):239-249

Department of Obstetrics and Gynecology, Washington University in St. Louis, 660 South Euclid, Mailbox 8064-37-905, Saint Louis, MO 63110, USA.

Although only accounting for a small percentage of infants born in the United States each year, assisted reproductive technology (ART) has become a more common means of conception since the first in vitro fertilization baby was born in 1978. An understanding of the ART process, medications, and complications is becoming essential for emergency medicine practice. Much of the surveillance data focuses on ART complications that are likely to be less relevant in the acute care setting, but ovarian hyperstimulation syndrome, ectopic pregnancy, and ovarian torsion are 3 diagnoses with high potential morbidity and mortality that emergency physicians should not miss. Read More

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http://dx.doi.org/10.1016/j.emc.2019.01.005DOI Listing
May 2019
4 Reads

Reproductive needs of PLHIV in Jamaica: relationship between fertility desire, motives and depression.

J Reprod Infant Psychol 2019 Apr 3:1-11. Epub 2019 Apr 3.

b The Hugh Wynter Fertility Management Unit , The University of the West Indies , Kingston , Jamaica.

Background/objective: Advances in antiretroviral therapy and assisted reproduction technology which allow for longer and healthier lives and safer conception options necessitate a new understanding of the sexual and reproductive needs of persons living with HIV (PLHIV). This study examines fertility desire and motives for having children among PLHIV in Jamaica and explores the association with depressive symptoms.

Methods: In a cross-sectional study, 251 PLHIV in their reproductive years voluntarily completed an interviewer-administered questionnaire. Read More

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http://dx.doi.org/10.1080/02646838.2019.1599334DOI Listing
April 2019
3 Reads

Transcriptome Analysis Suggests the Roles of Long Intergenic Non-coding RNAs in the Growth Performance of Weaned Piglets.

Front Genet 2019 18;10:196. Epub 2019 Mar 18.

Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, China.

Long intergenic non-coding RNAs (lincRNAs) have been considered to play a key regulatory role in various biological processes. An increasing number of studies have utilized transcriptome analysis to obtain lincRNAs with functions related to cancer, but lincRNAs affecting growth rates in weaned piglets are rarely described. Although lincRNAs have been systematically identified in various mouse tissues and cell lines, studies of lincRNA in pigs remain rare. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2019.00196
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http://dx.doi.org/10.3389/fgene.2019.00196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431659PMC
March 2019
6 Reads

First cryopreservation of phyllostomid bat sperm.

Theriogenology 2019 Mar 19;131:28-31. Epub 2019 Mar 19.

Leibniz Institute for Zoo and Wildlife Research, PF 700430, D-10342, Berlin, Germany.

Bats, the second-largest mammalian order, are widely distributed and provide crucial ecosystem services. Their reproductive biology comprises noteworthy characteristics, such as long-term sperm storage, delayed implantation or even delayed fetal development. The understanding of these mechanisms remains limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093691X183072
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http://dx.doi.org/10.1016/j.theriogenology.2019.03.014DOI Listing
March 2019
6 Reads

Association of In Vitro Fertilization With Childhood Cancer in the United States.

JAMA Pediatr 2019 Apr 1:e190392. Epub 2019 Apr 1.

Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, East Lansing.

Importance: In vitro fertilization (IVF) is associated with birth defects and imprinting disorders. Because these conditions are associated with an increased risk of childhood cancer, many of which originate in utero, descriptions of cancers among children conceived via IVF are imperative.

Objective: To compare the incidence of childhood cancers among children conceived in vitro with those conceived naturally. Read More

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http://archpedi.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamapediatrics.2019.0392DOI Listing
April 2019
8 Reads

Consultation and treatment behaviour of infertile couples in China: a population-based study.

Reprod Biomed Online 2019 Jan 8. Epub 2019 Jan 8.

Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; National Clinical Research Centre for Obstetrics and Gynecology, Beijing 100191, China; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China; Beijing Advanced Innovation Centre for Genomics, Beijing 100871, China; Peking-Tsinghua Centre for Life Sciences, Peking University, Beijing 100871, China. Electronic address:

Research Question: The prevalence of infertility in couples actively trying to conceive is 25%. What is the consultation-seeking behaviour, diagnosis and related treatment in infertile couples across China?

Design: Large cross-sectional population-based study in 2010-2011, in which 25,270 couples from eight provinces/municipalities in China were approached by a multistage stratified cluster sampling strategy.

Results: Among the 2680 couples reporting infertility, 1246 infertile couples consulted a fertility doctor. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.11.034DOI Listing
January 2019
3 Reads

Seminal plasma transferrin effects on cryopreserved common carp Cyprinus carpio sperm and comparison with bovine serum albumin and antifreeze proteins.

Anim Reprod Sci 2019 May 23;204:125-130. Epub 2019 Mar 23.

CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China. Electronic address:

In the current study, there was evaluation of the cryopreservation effectiveness of common carp Cyprinus carpio sperm when cryopreservation medium was supplemented with proteins. Semen was diluted with Kurokura's extender composing 180 mM NaCl, 2.68 mM KCl, 1. Read More

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http://dx.doi.org/10.1016/j.anireprosci.2019.03.013DOI Listing
May 2019
1 Read

DNA methylation and functional characterization of the XIST gene during in vitro early embryo development in cattle.

Epigenetics 2019 Mar 29:1-21. Epub 2019 Mar 29.

a Laboratory of Animal Reproduction, Embrapa Genetic Resources and Biotechnology , Parque Estação Biológica , Brasília , Brazil.

XIST, in association with the shorter ncRNA RepA, are essential for the initiation of X chromosome inactivation (XCI) in mice. The molecular mechanisms controlling XIST and RepA expression are well characterized in that specie. However, little is known in livestock. Read More

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http://dx.doi.org/10.1080/15592294.2019.1600828DOI Listing
March 2019
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A Strength, Weaknesses, Opportunities and Threats analysis on time lapse.

Curr Opin Obstet Gynecol 2019 Mar 28. Epub 2019 Mar 28.

IVIRMA Global, Valencia, Spain.

Purpose Of Review: The study of embryonic development through conventional microscopy has contributed significantly to the success of IVF. However, clinical pregnancy rates per transfer remain as low as 30% according to the latest records of European society if human reproduction and society if assisted reproduction. Considering the increased need to reduce the number of multiple pregnancies, the embryologist is required to improve embryo selection methods to reduce the number of embryos transferred and identify those with the highest implantation potential. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000534DOI Listing
March 2019
3 Reads

Higher chromosomal aberration rate in miscarried conceptus from polycystic ovary syndrome women undergoing assisted reproductive treatment.

Fertil Steril 2019 Mar 25. Epub 2019 Mar 25.

Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, and Henan Province Key Laboratory of Reproduction and Genetics, Henan, People's Republic of China. Electronic address:

Objective: To assess the potential association between polycystic ovary syndrome (PCOS) and chromosomally aberrant miscarriage during treatment with assisted reproductive technology (ART).

Design: A retrospective, single-center study.

Setting: University-affiliated reproductive center. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.01.026DOI Listing
March 2019
3 Reads

The myo-inositol effect on the oocyte quality and fertilization rate among women with polycystic ovary syndrome undergoing assisted reproductive technology cycles: a randomized clinical trial.

Arch Gynecol Obstet 2019 Mar 27. Epub 2019 Mar 27.

Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences, PO Box: 15875-1454, 1168743514, Tehran, Iran.

Purpose: The aim of the present study was to evaluate the effect of myo-Inositol administration on oocyte quality, fertilization rate and embryo quality in patients with PCOS during assisted reproductive technology (ART) cycles.

Methods: Fifty infertile PCOS patients were randomly designated in two groups. In the study group, patients received daily doses of 4 g myo-Inositol combined with 400 mg folic acid and in the control group patients received only 400 mg folic acid from 1 month before starting the antagonist cycle until the day of ovum pick up. Read More

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http://dx.doi.org/10.1007/s00404-019-05111-1DOI Listing
March 2019
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Single nucleotide polymorphisms in candidate genes are significantly associated with resistance to infection in goats.

J Anim Sci Biotechnol 2019 15;10:30. Epub 2019 Mar 15.

1Key Lab of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070 People's Republic of China.

Background: Haemonchosis is a major economic problem in goat production in humid, tropical and subtropical regions. The disease is caused by an abomasal nematode, , which is highly pathogenic in small ruminants The aim of this study was to identifying single-nucleotide polymorphisms (SNP) that were associated with fecal egg counts (FEC) and could be used as markers to identify resistance to in goats.

Results: Ten novel variants in the , and genes were associated with FEC in goats with a nominal significance level of  < 0. Read More

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http://dx.doi.org/10.1186/s40104-019-0327-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419443PMC
March 2019
3 Reads

Progesterone elevation on the day of hCG trigger has detrimental effect on live birth rate in low and intermediate ovarian responders, but not in high responders.

Sci Rep 2019 Mar 26;9(1):5127. Epub 2019 Mar 26.

Department of Reproductive Medicine, The First People's Hospital of Yunnan Province, Kunming, China.

Progesterone elevation (PE) on the day of hCG trigger is associated with decreased pregnancy outcome in fresh cycles. Evidence for this comes from overall patient estimates that mostly ignore different ovarian responses. To compare the impacts of PE on the day of hCG trigger on live birth rates (LBs) in low, intermediate and high ovarian responders and to explore the cut-off value for PE in different populations according to the ovarian response, we retrospectively analyzed a total of 2,351 patients receiving fresh assisted reproduction technology (ART) transfer cycles with GnRH agonist using a long or short protocol. Read More

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http://dx.doi.org/10.1038/s41598-019-41499-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435811PMC
March 2019
2 Reads
5.078 Impact Factor

Palmitic acid causes insulin resistance in granulosa cells via activation of JNK.

J Mol Endocrinol 2019 Mar 1. Epub 2019 Mar 1.

Z Chen, Center for Reproductive Medicine, Shandong University, Jinan, China.

Obesity is a worldwide health problem with rising incidence and results in reproductive difficulties. Elevated saturated free fatty acids (FFAs) in obesity can cause insulin resistance (IR) in peripheral tissues. The high intra-follicular saturated FFAs may also account for IR in ovarian granulosa cells (GCs). Read More

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https://jme.bioscientifica.com/view/journals/jme/aop/jme-18-
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http://dx.doi.org/10.1530/JME-18-0214DOI Listing
March 2019
7 Reads

The Effects of Overweight and Obesity on Assisted Reproduction Technology Outcomes.

JBRA Assist Reprod 2019 Mar 26. Epub 2019 Mar 26.

Nilo Frantz Reproductive Medicine, Porto Alegre, RS, Brazil.

The aim of the present study was to assess the impact of professional nutrition assistance on assisted reproduction technology (ART) outcomes in overweight or obese patients with polycystic ovarian syndrome (PCOS). The study represents a retrospective analysis of fertilization rates, embryo quality and gestations after ART in seven PCOS patients, five obese and two overweight. The women attended a private Fertility Center in Brazil between the years 2010 and 2016. Read More

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http://dx.doi.org/10.5935/1518-0557.20190005DOI Listing
March 2019
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Influence of metabolic syndrome on female fertility and in vitro fertilization outcomes in PCOS women.

Am J Obstet Gynecol 2019 Mar 22. Epub 2019 Mar 22.

Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 845 Lingshan Road, Shanghai 200135, P.R. China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, 845 Lingshan Road, Shanghai 200135, P.R. China. Electronic address:

Objective: With a high incidence of insulin resistance, central obesity and dyslipidemia, polycystic ovary syndrome (PCOS) women are susceptible to metabolic syndrome (MetS). Our objective was to explore whether MetS had an effect on overall female fertility and in vitro fertilization (IVF) outcomes in PCOS infertile women.

Methods: This was a secondary analysis of a multicenter randomized trial in 1508 PCOS women, which was originally designed to compare live birth rate after fresh embryo transfer vs. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.03.011DOI Listing
March 2019
4 Reads

Effect of low-dose aspirin on the development of ovarian hyperstimulation syndrome and outcomes of assisted reproductive techniques in the women with PCOS, a randomized double-blinded clinical trial.

Taiwan J Obstet Gynecol 2019 Mar;58(2):255-260

Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Objective: Ovarian hyperstimulation syndrome (OHSS) is a major complication of assisted reproductive technologies (ART). Polycystic ovary syndrome (PCOS) is a risk factor for OHSS. The aim of this randomized clinical trial (RCT) was to study the effect of low-dose aspirin (LDA) on the development of OHSS and ART outcomes in PCOS during ART. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.01.016DOI Listing

Design of a multi-sensor platform for integrating extracellular acidification rate with multi-metabolite flux measurement for small biological samples.

Biosens Bioelectron 2019 May 11;133:39-47. Epub 2019 Mar 11.

Department of Electrical and Computer Engineering, Colorado State University, Fort Collins, CO 80523, USA; School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA. Electronic address:

Rates of cellular oxygen consumption (OCR) and extracellular acidification (ECAR) are widely used proxies for mitochondrial oxidative phosphorylation (OXPHOS) and glycolytic rate in cell metabolism studies. However, ECAR can result from both oxidative metabolism (carbonic acid formation) and glycolysis (lactate release), potentially leading to erroneous conclusions about metabolic substrate utilization. Co-measurement of extracellular glucose and lactate flux along with OCR and ECAR can improve the accuracy and provide better insight into cellular metabolic processes but is currently not feasible with any commercially available instrumentation. Read More

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http://dx.doi.org/10.1016/j.bios.2019.02.069DOI Listing
May 2019
2 Reads

Expanded Preconception Carrier Screening in Clinical Practice: Review of Technology, Guidelines, Implementation Challenges, and Ethical Quandaries.

Clin Obstet Gynecol 2019 Mar 22. Epub 2019 Mar 22.

Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University.

In the last 10 years, expanded preconception carrier screening has become widely available and helps patients/couples make more informed decisions with regard to their reproductive options and facilitates more effective preconception planning, prenatal diagnosis, condition-specific counseling, and condition-specific care. This review provides an overview of expanded preconception carrier screening's high-throughput genotyping and sequencing approaches, current guidelines, implementation challenges and evolving ethical quandaries. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000437DOI Listing
March 2019
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Examining the Role of Dyadic Coping on the Marital Adjustment of Couples Undergoing Assisted Reproductive Technology (ART).

Front Psychol 2019 8;10:415. Epub 2019 Mar 8.

Department of Psychology, Catholic University of Sacred Hearth, Milan, Italy.

A couple is considered to be infertile if unable to conceive after 12 months of unprotected sexual intercourse. An extended body of literature supports that infertility and infertility treatments contribute to emotional, social, sexual, and relational issues that can have a negative impact on each partner's well-being and on the couple relationship. Recent findings suggest that a dyadic approach should be used when working with couples coping with these stressors. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418016PMC
March 2019
3 Reads

Human oocyte morphometry before and after cryopreservation: A prospective cohort study.

Cryobiology 2019 Mar 21. Epub 2019 Mar 21.

Division of Human Reproduction, Hospital Das Clínicas, Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

The cryopreservation of human oocytes is an important strategy to spare fertility in women submitted to gonadotoxic therapy, ovarian surgery, or even to allow gestation by assisted reproduction technology after natural ovarian senescence. Methods to predict oocyte resistance to cryopreservation are still based on qualitative morphological assessment. In this study we evaluated whether morphometric characteristics of mature oocytes before vitrification and after warming are related to successful fertilization by intracytoplasmic sperm injection (ICSI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00112240193006
Publisher Site
http://dx.doi.org/10.1016/j.cryobiol.2019.03.007DOI Listing
March 2019
8 Reads

Update on oxidative stress and inflammation in pregnant women, unborn children (nasciturus), and newborns - Nutritional and dietary effects.

Free Radic Biol Med 2019 Mar 19. Epub 2019 Mar 19.

Group on Safety, Quality, and Bioactivity of Plant Foods, Department of Food Science and Technology, (CEBAS-CSIC), University Campus of Espinardo, Edif. 25, 30100, Murcia, Spain.

The scientific background of perinatal pathology, regarding both mother and offspring, from the lipidomic perspective, has highlighted the possibility of identifying new, promising clinical markers of oxidative stress and inflammation, closely related to the normal development of unborn and newborn children, together with their application. In this regard, in recent years, significant advances have been achieved, assisted by both newly developed analytical tools and basic knowledge on the biological implications of oxylipins. Hence, in the light of this recent progress, this review aims to provide an update on the relevance of human oxylipins during pregnancy and in the unborn and newborn child, covering two fundamental aspects. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.03.013DOI Listing
March 2019
2 Reads

A protocol developing, disseminating and implementing a core outcome set for infertility.

Hum Reprod Open 2018 15;2018(3):hoy007. Epub 2018 Jun 15.

Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand.

Study Questions: We aim to produce, disseminate and implement a core outcome set for future infertility research.

What Is Known Already: Randomized controlled trials (RCTs) evaluating infertility treatments have reported many different outcomes, which are often defined and measured in different ways. Such variation contributes to an inability to compare, contrast and combine results of individual RCTs. Read More

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http://dx.doi.org/10.1093/hropen/hoy007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276643PMC
June 2018
2 Reads