8,640 results match your criteria Assisted Reproduction Technology


Genome-wide association study for reproduction-related traits in Chinese domestic goose.

Br Poult Sci 2022 Jul 1. Epub 2022 Jul 1.

Chongqing Academy of Animal Science, Rongchang County, Chongqing, 402460, P. R. China.

1. This study measured six reproduction traits in a Sichuan white goose population (209 individuals), including fertility, qualified egg rate, plasma concentrations of progesterone (P), follicle-stimulating hormone (FSH), prolactin (PRL) and oestrogen (E2).2. Read More

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Effect of advanced paternal age on reproductive outcomes in IVF cycles of non-male-factor infertility: a retrospective cohort study.

Asian J Androl 2022 Jun 21. Epub 2022 Jun 21.

Reproductive Medicine Center, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China.

Advanced paternal age has been overlooked, and its effect on fertility remains controversial. Previous studies have focused mainly on intracytoplasmic sperm injection (ICSI) cycles in men with oligozoospermia. However, few studies have reported on men with semen parameters within reference ranges. Read More

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Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis.

Reprod Biomed Online 2022 May 17. Epub 2022 May 17.

Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco CA, USA. Electronic address:

Research Question: Adenomyosis is a common uterine disorder of uncertain causes. Can transcriptomic analyses of the endometrium and myometrium reveal potential mechanisms underlying adenomyosis pathogenesis?

Design: Transcriptomic profiles of eutopic endometrium and myometrium from women with and without diffuse adenomyosis and with symptomatic FIGO type 2-5 fibroids in the proliferative phase of the menstrual cycle were assessed using RNA sequencing and bioinformatic analysis. Differentially expressed genes (DEG) and potential pathways were validated by quantitative reverse transcription polymerase chain reaction, immunoblotting and Masson staining, using additional clinical samples. Read More

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A genome-wide association study of important reproduction traits in Large White pigs.

Gene 2022 Jun 27:146702. Epub 2022 Jun 27.

College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, P. R. China. Electronic address:

Augmenting the reproductive efficiency of sows remains the predominant challenge in the swine industry. This work was aimed at scrutinizing vital genetic markers for reproductive traits in this animal. This entailed probing of the records of vital attributes of Large White pigs (n=695) inclusive of the total number of born (TNB), number of born alive (NBA), number of weaned pigs (NWP), number of healthy births (NHS), total litter weight of piglets born alive (BALWT), weaning litter weight (WNWT), and corrected litter weight at 21 days (W21). Read More

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SNP within the bovine ASB-3 gene and their association analysis with stature traits in three Chinese cattle breeds.

Gene 2022 Jun 27:146700. Epub 2022 Jun 27.

Shaanxi Key Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Northwest A&F University, Shaanxi 712100, China. Electronic address:

ASB-3 is one of the 18 members of ASB gene family. As a special negative regulation factor of TNF-R2, ASB-3 inhibits the signal transduction of JNK-TNF-R2 and JNK-STAT signaling pathway by TNF-R2 protein. In this study, the genetic polymorphisms of ASB-3 were detected in total of 637 from Qinchuan, Jinnan and Xianan cattle using the sequence of mixed DNA pool, Tetra-primer ARMS-PCR and PCR-RFLP methods. Read More

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Cohort profile: Anhui Maternal-Child Health Study in China.

BMJ Open 2022 Jun 28;12(6):e060091. Epub 2022 Jun 28.

Centre for Health and Social Care Improvement, University of Wolverhampton, Wolverhampton, UK

Purpose: The Anhui Maternal-Child Health Study (AMCHS) aims to examine determinants of reproduction, pregnancy and postpartum maternal and child health outcomes in Chinese women who received assisted reproductive technology (ART).

Study Design And Participants: AMCHS is an ongoing cohort study starting from May 2017. AMCHS recruits participants from all couples who sought ART treatment in the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Read More

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Individual and community-level factors associated with skilled birth attendants during delivery in Bangladesh: A multilevel analysis of demographic and health surveys.

PLoS One 2022 29;17(6):e0267660. Epub 2022 Jun 29.

Institute for Physical Activity and Nutrition, Deakin University, Melbourne, Victoria, Australia.

Background: Skilled birth attendants (SBAs) play a crucial role in reducing infant and maternal mortality. Although the ratio of skilled assistance at birth has increased in Bangladesh, factors associated with SBA use are unknown. The main goal of our study was to reveal the individual- and community-level factors associated with SBA use during childbirth in Bangladesh. Read More

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Adaptive data-driven models to best predict the likelihood of live birth as the IVF cycle moves on and for each embryo transfer.

J Assist Reprod Genet 2022 Jun 29. Epub 2022 Jun 29.

Teranalytics, Artificial Intelligence Division, Newton, USA.

Purpose: To dynamically assess the evolution of live birth predictive factors' impact throughout the in vitro fertilization (IVF) process, for each fresh and subsequent frozen embryo transfers.

Methods: In this multicentric study, data from 13,574 fresh IVF cycles and 6,770 subsequent frozen embryo transfers were retrospectively analyzed. Fifty-seven descriptive parameters were included and split into four categories: (1) demographic (couple's baseline characteristics), (2) ovarian stimulation, (3) laboratory data, and (4) embryo transfer (fresh and frozen). Read More

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Mapping developmental paths of monkey primordial germ-like cells differentiation from pluripotent stem cells by single cell RNA sequencing analysis.

Biol Reprod 2022 Jun 29. Epub 2022 Jun 29.

State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.

The induction of primordial germ-like cells (PGCLCs) from pluripotent stem cells (PSCs) provides a powerful system to study the cellular and molecular mechanisms underlying germline specification, which are difficult to study in vivo. The studies reveal the existence of species-specific mechanism underlying PGCLCs between human and mouse, highlighting the necessity to study regulatory networks in more species, especially in primates. Harnessing the power of single cell RNA sequencing (scRNA-seq) analysis, the detailed trajectory of human PGCLCs specification in vitro has been achieved. Read More

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PGT-A: The biology and hidden failures of randomized control trials.

Prenat Diagn 2022 Jun 28. Epub 2022 Jun 28.

Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing, China.

Objective: PGT-A for embryo selection has undergone significant advancements in the last two decades and yet many studies still fail to demonstrate any clinical benefits over traditional embryo morphology selection. To understand this conundrum, we performed a multi-center clinical study of PGT-A patients, where morphology selection (Mo-S) and euploid selection (Eu-S) outcomes were directly compared.

Method: All suitable blastocysts were biopsied and analysed for chromosome copy number. Read More

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Endometrial thickness is an independent risk factor of hypertensive disorders of pregnancy: a retrospective study of 13,458 patients in frozen-thawed embryo transfers.

Reprod Biol Endocrinol 2022 Jun 28;20(1):93. Epub 2022 Jun 28.

Center for Reproductive Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.

Background: Hypertensive disorders of pregnancy (HDP) are an important cause of maternal and fetal mortality, and its potential risk factors are still being explored. Endometrial thickness (EMT), as one of the important monitoring indicators of endometrial receptivity, has been confirmed to be related to the incidence of HDP in fresh embryo transfer. Our study was designed to investigate whether endometrial thickness is associated with the risk of hypertensive disorders of pregnancy in frozen-thawed embryo transfer (FET). Read More

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Analysis of the risk of complications during pregnancy in pregnant women with assisted reproductive technology: a retrospective study using registry linkage from 2013 to 2018 in Shanghai, China.

BMC Pregnancy Childbirth 2022 Jun 28;22(1):526. Epub 2022 Jun 28.

Shanghai JiAi Genetics & IVF Institute, Shanghai, 200011, China.

Background: To evaluate the differences in pregnancy outcomes between assisted reproductive technology (ART) patients and natural pregnant women in Shanghai, China in the past 6 years objectively. And to assess the feasibility of the research method of registry-database linkage in mainland China.

Methods: This retrospective study was conducted using registry-database linkage. Read More

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Outcomes of Empirical Treatment With Intravenous Immunoglobulin G Combined With Low-Dose Aspirin in Women With Unexplained Recurrent Pregnancy Loss.

J Korean Med Sci 2022 Jun 27;37(25):e200. Epub 2022 Jun 27.

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Background: To assess the clinical efficacy of intravenous immunoglobulin G (IVIG) administration combined with low-dose aspirin in women with unexplained recurrent pregnancy loss (RPL).

Methods: We retrospectively analyzed the medical records of patients who had been diagnosed with unexplained RPL and treated with IVIG and low-dose aspirin between January 2000 and March 2020 at Asan Medical Center. We analyzed pregnancy outcomes and their association with the percentage of natural killer (NK) cells. Read More

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Administration of progesterone on the day of oocyte retrieval to reverse accumulation of fluid in the endometrial cavity during assisted reproductive techniques.

JBRA Assist Reprod 2014 Dec 27;18(4):136-138. Epub 2014 Dec 27.

Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, SP, Brazil.

Objective: To determine whether administration of progesterone on the day of oocyte retrieval may reverse accumulation of fluid in the endometrial cavity.

Methods: A total of 50 patients who underwent assisted reproductive technology (ART) cycles with endometrial cavity fluid (ECF) observed by ultrasound at the time of oocyte retrieval were included. Upon the identification of ECF, vaginal administration of natural progesterone was started. Read More

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December 2014

Postmortem sperm retrieval for in vitro fertilization treatment: care to be taken - a Brazilian case report.

JBRA Assist Reprod 2014 Sep 27;18(3):85-87. Epub 2014 Sep 27.

Center of Human Reproduction of Sao Jose do Rio Preto, São José do Rio Preto - SP, Brazil.

Postmortem sperm retrieval has been used worldwide in assisted reproduction technology. Nevertheless, the laws vary from country to country according to cultural, ethical and religious reasons. However, for postmortem sperm retrieval to be used, it is necessary that a preview informed consent be signed by the couple. Read More

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September 2014

Incidence and anatomy of cardiac malformations in children conceived by assisted reproduction techniques - A review.

JBRA Assist Reprod 2014 Jun 27;18(2):52-54. Epub 2014 Jun 27.

Department of Phisioterapy, Pontifical Catholic University of Minas Gerais, Brazil.

The aim of this study is to identify the occurrence of cardiac malformations occurred in children conceived by assisted reproduction techniques (ART) in the international literature in Medline database from 1999 to 2012. The search returned data on 32,000 births, whose 21,000 were conceived naturally and 11,000 were conceived by ICSI and/or IVF. The incidence of cardiac malformations in general population situations was 0. Read More

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Latin America and access to Assisted Reproductive Techniques: A Brazilian perspective.

JBRA Assist Reprod 2014 Jun 27;18(2):47-51. Epub 2014 Jun 27.

REDLARA - The Latin American Network of Assisted Reproduction.

Introduction: In Brazil, as in all Latin America, access to infertility care, including assisted reproductive technology (ART) is on debate. This paper evaluates the availability and access of Brazilian couples to ART services.

Methods: It is a qualitative study conducted about the Brazilian possibilities of ART in the public sector. Read More

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Ovarian stimulation with GnRH analogues.

JBRA Assist Reprod 2014 Jun 27;18(2):42-46. Epub 2014 Jun 27.

Gynecology and Obstetrics Service of the Hospital de Clínicas de Porto Alegre, Assisted Reproductive Sector, Federal University of Rio Grande do Sul.

Objective: Analysis and compare data between two induction protocols (long agonist and flexible antagonist) in patients submitted an assisted reproduction technique in Porto Alegre.

Methods: Cross-sectional study comparing the intermediate results with the use of two different ovarian stimulation protocols with gonadotropin-releasing hormone agonist versus antagonist to assisted reproductive techniques. The statistical analysis of the retrieved data (age, body mass index, number of oocytes recovered, number of fertilized oocytes, number of oocytes cleaved, total dose of FSH used and ovarian hyperstimulation syndrome) was performed by Student's t-test for parametric data and analysis of covariance for the dependent variables. Read More

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Perinatal outcome of babies born after using a simplified IVF culture system versus ICSI with sibling oocytes: a prospective cohort study.

Reprod Biomed Online 2022 Jun 16. Epub 2022 Jun 16.

Department of Obstetrics and Gynaecology, Genk Institute for Fertility Technology, Campus St Jan, ZOL, Genk, Belgium.

Research Question: Is there a difference in perinatal outcome in the same patient cohort for babies conceived following randomization of sibling oocytes allocated to a simplified IVF culture system (SCS) or intracytoplasmic sperm injection (ICSI) followed by conventional culturing?

Design: The study compared the perinatal outcomes of 367 babies born from 1 January 2013 until 31 December 2020 after using split SCS and ICSI insemination of sibling oocytes in a selected group of normo-responsive women, excluding cases of severe male infertility. Primary outcome measures were preterm birth (PTB; <37 weeks' gestation), low birthweight (LBW; <2.5 kg) and small for gestational age (SGA) as a primary outcome parameter while secondary outcome measures included mean birthweight, mean gestational age, extreme prematurity (<32 weeks), very low birthweight (<1. Read More

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An Automated Deep Learning Model for the Cerebellum Segmentation from Fetal Brain Images.

Biomed Res Int 2022 16;2022:8342767. Epub 2022 Jun 16.

Department of Mechanical Engineering, St. Joseph College of Engineering and Technology, St. Joseph University, Tanzania.

Cerebellum measures taken from routinely obtained ultrasound (US) images have been frequently employed to determine gestational age and identify developing central nervous system's anatomical abnormalities. Standardized cerebellar assessments from large-scale clinical datasets are required to investigate correlations between the growing cerebellum and postnatal neurodevelopmental results. These studies could uncover structural abnormalities that could be employed as indicators to forecast neurodevelopmental and growth consequences. Read More

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[Fertility preservation and access to medically assisted reproduction for Trans people: Guidelines from French Professional Association for Transgender Health].

Gynecol Obstet Fertil Senol 2022 Jun 21. Epub 2022 Jun 21.

CHU de Nantes, Biologie et Médecine de la Reproduction et gynécologie médicale, Nantes Université, Inserm, Centre de Recherche en Transplantation et immunologie, UMR 1064, Nantes, France.

Many health care professionals are dealing with the issue of transgender people in their medical practice. In the field of reproduction, Trans people can benefit from fertility preservation before the introduction of hormonal treatment or surgery altering their fertility. This article, which is the result of a collaborative work of several reproductive professionals involved in the health of Trans people, provides an overview of the possibilities of fertility preservation and medically assisted reproduction techniques in France for Trans people. Read More

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Advances in the ultrasound diagnosis in equine reproductive medicine: new approaches.

Reprod Domest Anim 2022 Jun 24. Epub 2022 Jun 24.

Laboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, Cáceres, Spain.

Ultrasound technology has led to new lines of research in equine reproduction, and it has helped to greatly improve clinical diagnosis and reproductive outcomes in equine practice. This review aims to discuss the potential clinical uses and new approaches of ultrasonography in equine reproduction. Doppler modalities are usually used to evaluate the vascularization of the follicles, corpus luteum (CL), and the uterus in the mare for diagnostic purposes. Read More

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Sperm cryopreservation in young males with congenital adrenal hyperplasia (CAH).

Clin Endocrinol (Oxf) 2022 Jun 23. Epub 2022 Jun 23.

Assistance publique - Hôpitaux de Paris (AP-HP) Centre - Université de Paris, Cochin, Service de Biologie de la Reproduction - CECOS, Paris, FR.

Infertility is one of the long-term complications of congenital adrenal hyperplasia (CAH) in male patients and may result in most cases from the development of testicular adrenal rest tumors (TART) (1). CAH, especially if TART are present, can impair spermatogenesis. Abnormal sperm parameters have been reported in several studies, mostly performed in small series of CAH patients, with a prevalence ranging from 17 to 72% (2, 3). Read More

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The Use of near Infra-Red Radiation Imaging after Injection of Indocyanine Green (NIR-ICG) during Laparoscopic Treatment of Benign Gynecologic Conditions: Towards Minimalized Surgery. A Systematic Review of Literature.

Medicina (Kaunas) 2022 Jun 13;58(6). Epub 2022 Jun 13.

Gynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry Schola Medica Salernitana, University of Salerno, 84081 Baronissi, Italy.

: To assess the use of near infrared radiation imaging after injection of indocyanine green (NIR-ICG) during laparoscopic treatment of benign gynecologic conditions. : A systematic review of the literature was performed searching 7 electronic databases from their inception to March 2022 for all studies which assessed the use of NIR-ICG during laparoscopic treatment of benign gynecological conditions. : 16 studies (1 randomized within subject clinical trial and 15 observational studies) with 416 women were included. Read More

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Effects of Melatonin on the Transcriptome of Human Granulosa Cells, Fertilization and Blastocyst Formation.

Int J Mol Sci 2022 Jun 16;23(12). Epub 2022 Jun 16.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Yamaguchi University, Minamikogushi 1-1-1, Ube 755-8505, Japan.

Melatonin is a promising reagent that can improve assisted reproductive technology (ART) outcomes in infertility patients. However, melatonin is not effective for all infertile patients, and it remains unclear for which patients melatonin would be effective. This study examined the effects of melatonin on ART outcomes and examined its mechanisms. Read More

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When Electrospun Fiber Support Matters: In Vitro Ovine Long-Term Folliculogenesis on Poly (Epsilon Caprolactone) (PCL)-Patterned Fibers.

Cells 2022 06 19;11(12). Epub 2022 Jun 19.

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.

Current assisted reproduction technologies (ART) are insufficient to cover the slice of the population needing to restore fertility, as well as to amplify the reproductive performance of domestic animals or endangered species. The design of dedicated reproductive scaffolds has opened the possibility to better recapitulate the reproductive 3D ovarian environment, thus potentially innovating in vitro folliculogenesis (ivF) techniques. To this aim, the present research has been designed to compare ovine preantral follicles in vitro culture on poly(epsilon-caprolactone) (PCL)-based electrospun scaffolds designed with different topology (Random vs. Read More

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Validation of Non-Invasive Preimplantation Genetic Screening Using a Routine IVF Laboratory Workflow.

Biomedicines 2022 Jun 11;10(6). Epub 2022 Jun 11.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Embryo selection is needed to optimize the chances of pregnancy in assisted reproduction technology. This study aimed to validate non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) using a routine IVF laboratory workflow. Can niPGT-A combined with time-lapse morphokinetics provide a better embryo-selection strategy? A total of 118 spent culture mediums (SCMs) from 32 couples were collected. Read More

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Follicular Fluid: A Powerful Tool for the Understanding and Diagnosis of Polycystic Ovary Syndrome.

Biomedicines 2022 May 27;10(6). Epub 2022 May 27.

Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.

Polycystic ovary syndrome (PCOS) represents one of the leading causes of anovulatory infertility and affects 5% to 20% of women worldwide. Until today, both the subsequent etiology and pathophysiology of PCOS remain unclear, and patients with PCOS that undergo assisted reproductive techniques (ART) might present a poor to exaggerated response, low oocyte quality, ovarian hyperstimulation syndrome, as well as changes in the follicular fluid metabolites pattern. These abnormalities originate a decrease of Metaphase II (MII) oocytes and decreased rates for fertilization, cleavage, implantation, blastocyst conversion, poor egg to follicle ratio, and increased miscarriages. Read More

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The Reproductive Outcome of Women with Hypogonadotropic Hypogonadism in IVF.

Front Endocrinol (Lausanne) 2022 6;13:850126. Epub 2022 Jun 6.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Objective: The purpose of this study was to evaluate the reproductive outcome of patients with hypogonadotropic hypogonadism (HH) receiving fertilization and embryo transfer (IVF-ET).

Methods: The reproductive outcome of 81 HH patients and 112 controls who underwent oocyte retrieval was evaluated retrospectively in the Center for Reproductive Medicine of Peking University Third Hospital from 2010 to 2019.

Results: The basic levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), androstenedione (A) and prolactin (PRL) were significantly lower in the HH group than the control group. Read More

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Dose-response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort study.

Reprod Biol Endocrinol 2022 Jun 22;20(1):92. Epub 2022 Jun 22.

Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China.

Background: The impact of maternal pre-pregnancy bodyweight on gestational diabetes mellitus (GDM) following assisted reproductive technology (ART) treatment has been insufficiently investigated. The aim of this study was to investigate the association between maternal pre-pregnancy bodyweight and GDM following ART.

Methods: From January 2014 to March 2019, this population-based retrospective cohort study included pregnancies achieved by ART treatment in a pregnancy registration database in China. Read More

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