1,390,857 results match your criteria Assessment & Evaluation In Higher Education[Journal]


[Follow-up of differentiated thyroid cancer].

Dtsch Med Wochenschr 2020 Jul 7. Epub 2020 Jul 7.

The management of differentiated thyroid carcinoma has shown considerable changes in recent years, moving away from a fixed therapy regimen towards individual treatment strategies. The aim of our work (literature research) is to present current developments in the follow-up of differentiated thyroid cancer.For the management of individual follow-up, an initial evaluation and, at later time points, the re-evaluation of the risk of recurrence is crucial. Read More

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http://dx.doi.org/10.1055/a-1007-4121DOI Listing

Serial assessment of fat and fat-free mass accretion in very preterm infants: a randomized trial.

Pediatr Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 35249, USA.

Background: Clinicians could modify dietary interventions during early infancy by monitoring fat and fat-free mass accretion in very preterm infants.

Methods: Preterm infants were randomly assigned to either having reports on infant body composition available to the clinicians caring for them (intervention group) or not having reports available (control group). All infants underwent serial assessments of body composition by air-displacement plethysmography before 32 weeks of postmenstrual age (PMA) and at 36 weeks PMA. Read More

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http://dx.doi.org/10.1038/s41390-020-1052-xDOI Listing

Depression and Cognitive Impairment in Institutionalized Older Adults.

Dement Geriatr Cogn Disord 2020 Jul 7:1-13. Epub 2020 Jul 7.

Department of Nursing, University Hospital of Ceuta, Ceuta, Spain.

Background: In the last three decades, the relationship between depression and cognition in geriatric patients has been a popular topic among researchers and clinicians. Clinical and epidemiological research has focused on the identification of risk factors that could be modified in pre-dementia syndromes, at a preclinical and early clinical stage of dementia disorders, with specific attention to the role of depression. The objective of this work was to determine the relationship between depressive disorder and cognitive deterioration in institutionalized older adults. Read More

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http://dx.doi.org/10.1159/000508626DOI Listing

Feasibility, Reliability, and Agreement of Transperineal Ultrasound Measurement: Results from a Longitudinal Cohort Study.

Fetal Diagn Ther 2020 Jul 7:1-10. Epub 2020 Jul 7.

Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong,

Objectives: To evaluate the feasibility, reliability, and agreement of serial transperineal ultrasound (TPU) assessment of fetal head station (parasagittal angle of progression [psAOP], head-perineum distance [HPD], and head-symphysis distance [HSD]) and sonographic cervical dilatation (SCD), compared to fetal head station and cervical dilatation determined by vaginal examination, respectively.

Methods: This was a prospective longitudinal study in singleton pregnancies undergoing induction of labor at term. Paired assessment of fetal head station and cervical dilatation by vaginal examination, with TPU assessment of psAOP, HPD, HSD, and SCD was made serially. Read More

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http://dx.doi.org/10.1159/000507549DOI Listing

Assessing the Association of Surface-Intermediate-Base Margin Score with Perioperative Outcomes and Parenchymal Volume Preserved during Partial Nephrectomy.

Urol Int 2020 Jul 7:1-8. Epub 2020 Jul 7.

Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.

Introduction: The present study aimed to compare the assessment of volume preservation and perioperative outcomes during partial nephrectomy (PN), according to the surface-intermediate-base (SIB) score.

Methods: This prospective study included 80 patients diagnosed with renal cell carcinoma who underwent PN for a renal mass from 2014 to 2017. SIB score was macroscopically evaluated immediately after the surgery. Read More

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http://dx.doi.org/10.1159/000508798DOI Listing

The Impact of the COVID-19 Pandemic and the Associated Belgian Governmental Measures on Cancer Screening, Surgical Pathology and Cytopathology.

Pathobiology 2020 Jul 7:1-10. Epub 2020 Jul 7.

Department of Pathology, Cliniques universitaires Saint-Luc, Brussels, Belgium,

Introduction: The severe acute respiratory syndrome coronavirus 2 caused a pandemic of coronavirus disease 2019 (COVID-19). Unprecedented public health actions were introduced, including social distancing, travel restrictions and quarantine. The Belgian government announced a national emergency plan, thereby postponing all non-urgent medical consultations and operations. Read More

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http://dx.doi.org/10.1159/000509546DOI Listing

Current Practices for Screening and Management of Financial Distress at NCCN Member Institutions.

J Natl Compr Canc Netw 2020 Jul;18(7):825-831

3Fred Hutchinson Cancer Research Center, University of Washington Children's Hospital, Seattle, Washington.

Background: Financial distress from medical treatment is an increasing concern. Healthcare organizations may have different levels of organizational commitment, existing programs, and expected outcomes of screening and management of patient financial distress.

Patients And Methods: In November 2018, representatives from 17 (63%) of the 27 existing NCCN Member Institutions completed an online survey. Read More

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http://dx.doi.org/10.6004/jnccn.2020.7538DOI Listing

Assessment pedestrian crossing safety using vehicle-pedestrian interaction data through two different approaches: Fixed videography (FV) vs In-Motion Videography (IMV).

Accid Anal Prev 2020 Jul 4;144:105661. Epub 2020 Jul 4.

Department of Civil Engineering, Babol Noshirvani University of Technology, Shariati Ave., PO Box: 4714871167, Babol, Iran. Electronic address:

A significant portion of pedestrian accidents occurs in the outskirts areas due to the high vehicle speed and lack of safety facilities for pedestrians. Behavioral study on drivers and pedestrians is the key to better understand the causes of pedestrian accidents in order to develop safety models. Despite numerous studies on pedestrian safety based on various roads, outskirt areas have not been considered. Read More

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http://dx.doi.org/10.1016/j.aap.2020.105661DOI Listing

Fat quantification of the rotator cuff musculature using dual-energy CT-A pilot study.

Eur J Radiol 2020 Jun 23;130:109145. Epub 2020 Jun 23.

Department of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, United States. Electronic address:

Purpose: To assess the ability of dual-energy CT (DECT) as a novel technique to quantify the degree of rotator cuff fat degeneration.

Method: Clinically indicated shoulder CT exams for evaluation of osteoarthritis, rotator cuff arthropathy, pain or instability, or preoperative planning were acquired using dual-source CT systems. Rotator cuff DECT fat fraction after material decomposition was calculated off the sagittal image. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109145DOI Listing

Inflammatory bowel disease nurses' perspectives: Prioritizing adolescent transition readiness factors.

J Pediatr Nurs 2020 Jul 4;55:29-39. Epub 2020 Jul 4.

Education & Music Library, University of Saskatchewan, 28 Campus Drive, Room 2003.7A Education Bldg., Saskatoon, SK S7N 0X1, Canada. Electronic address:

Purpose: Despite the wealth of knowledge and expertise that Inflammatory Bowel Disease (IBD) nurses bring to the transition process, health literature lacks nurses' perspectives on transition readiness. The purpose of study was to ask IBD nurses to prioritize care transition readiness factors for adolescents living with IBD.

Design And Methods: The cross-sectional exploratory survey was researcher-developed and distributed online to IBD nurses across Canada. Read More

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http://dx.doi.org/10.1016/j.pedn.2020.06.011DOI Listing

AI-PLAX: AI-based placental assessment and examination using photos.

Comput Med Imaging Graph 2020 Jun 1;84:101744. Epub 2020 Jun 1.

The Pennsylvania State University, University Park, PN, USA. Electronic address:

Post-delivery analysis of the placenta is useful for evaluating health risks of both the mother and baby. In the U.S. Read More

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http://dx.doi.org/10.1016/j.compmedimag.2020.101744DOI Listing

Comparative study on photocatalytic degradation of the antidepressant trazodone using (Co, Fe and Ru) doped titanate nanowires: Kinetics, transformation products and in silico toxicity assessment.

Chemosphere 2020 Jul 1;259:127486. Epub 2020 Jul 1.

Departamento de Química e Bioquímica, Faculdade de Ciências, ULisboa, 1749-016, Lisboa, Portugal; Laboratório de FTICR e Espectrometria de Massa Estrutural, Faculdade de Ciências, ULisboa, 1749-016, Lisboa, Portugal.

Titanate nanomaterials have been outstanding in the removal of emerging contaminants by the photocatalysis process. These photocatalysts, when modified through techniques such as doping with metals, they have advantages over TiO, especially in the region of visible light. In this work, the photocatalytic performance of four recent reported catalysts, pristine titanate nanowires, cobalt-doped titanate nanowires, iron-doped titanate nanowires and ruthenium-doped titanate nanowires, for the removal of the antidepressant trazodone under visible light radiation was compared. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127486DOI Listing

Effect of fomesafen on the embryonic development of zebrafish.

Chemosphere 2020 Jun 12;259:127380. Epub 2020 Jun 12.

Center for drug screening and research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China; College of life and science, Gannan Normal University, Ganzhou, 341000, Jiangxi, China; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Ji'an, 343009, Jiangxi, China; Jiangxi Key Laboratory of Developmental Biology of Organs, Jinggangshan University, Ji'an, 343009, Jiangxi, China. Electronic address:

Fomesafen is widely used in agriculture and can be detected in the environment and agricultural products. Research on the developmental toxicity of fomesafen in animals is currently very limited. Here, we used zebrafish as an animal model to evaluate the toxicity of fomesafen in developing aquatic vertebrates and higher animals. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127380DOI Listing

Cognitive performance and psychosocial functioning in unaffected siblings of bipolar disorder patients in comparison with healthy controls.

Asian J Psychiatr 2020 Jun 29;54:102246. Epub 2020 Jun 29.

Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

We aimed to evaluate the cognitive domains for endophenotypes and their bearing on psychosocial functioning in unaffected siblings of patients with bipolar type I disorder (BD-I). We recruited unaffected siblings (n = 60) and age (±2 years), gender and education-matched healthy control subjects (n = 60) after screening with Structured clinical interview for DSM-IV-TR axis I disorders (SCID-I) - Research Version, Young Mania rating scale (YMRS), Hamilton depression rating scale (HDRS) and Family Interview for Genetic Studies scale (FIGS). Cognitive functioning was evaluated using Addenbrooke's Cognitive Examination III Revised (ACE-III R) and Trail making tests A and B, whereas psychosocial functioning was evaluated using the Social and Occupational Functioning Assessment Scale (SOFAS). Read More

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http://dx.doi.org/10.1016/j.ajp.2020.102246DOI Listing

Assessing the environmental sustainability of an emerging energy technology: Solar thermal calcination for cement production.

Sci Total Environ 2020 Jun 26;742:140510. Epub 2020 Jun 26.

Sustainable Industrial Systems, Department of Chemical Engineering and Analytical Science, The University of Manchester, Manchester M13 9PL, UK. Electronic address:

Cement production is a highly energy-intensive process, contributing 7% to global CO emissions. Over 80% of the energy used in cement production is consumed by the calcination process. This paper considers a novel solar thermal technology for calcination, to investigate if it could help mitigate the climate change and other environmental impacts from cement production on a life cycle basis. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140510DOI Listing

Impact of maternal physical activity during an uncomplicated pregnancy on fetal and neonatal well-being parameters: a systematic review of the literature.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 29;252:265-272. Epub 2020 Jun 29.

Obstetric Research Lab, Women-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.

We carried a thorough systematic review of the contemporary literature regarding the impact of maternal physical activity during pregnancy on the fetal and neonatal well-being parameters. We searched systematically publications indexed in PubMed and ScienceDirect, according to the PRISMA protocol. Studies examining following fetal and neonatal well-being parameters were included: fetal heart rate, active fetal movements, Doppler assessment of the placental and fetal circulations, amniotic fluid index, Apgar score, and umbilical cord blood acid-basis analysis at delivery. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.061DOI Listing

The utility of risk scores when evaluating for acute myocardial infarction using high-sensitivity cardiac troponin I.

Am Heart J 2020 May 30;227:1-8. Epub 2020 May 30.

Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI.

Risk scores including the Thrombolysis in Myocardial Infarction (TIMI) score; History, Electrocardiogram, Age, Risk Factors, and Troponin (HEART) score; and Simplified Emergency Department Assessment of Chest Pain Score (sEDACS) have been used to evaluate patients with symptoms suggestive of acute myocardial infarct (AMI). This study assessed prognostic utility of cardiac risk stratification scores when augmented with a high-sensitivity cardiac troponin-I assay (hs-cTnI).

Methods: This study enrolled 2,505 suspected AMI patients at 29 hospitals in the United States from April 2015 to April 2016. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.05.014DOI Listing

Methylsiloxanes in plasma from potentially exposed populations and an assessment of the associated inhalation exposure risk.

Environ Int 2020 Jul 4;143:105931. Epub 2020 Jul 4.

State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China. Electronic address:

Methylsiloxanes (MSs) are ubiquitous in indoor air and pose an important health risk. Thus, assessments of indoor inhalation exposure by measuring MSs levels in plasma are needed. In this study, we measured plasma MSs concentrations and evaluated daily indoor inhalation exposure in potentially exposed populations, including residents of industrial areas, university campus, and residential areas, all located in southwestern China. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105931DOI Listing

Short-term exposure to carbon monoxide and myocardial infarction: A systematic review and meta-analysis.

Environ Int 2020 Jul 4;143:105901. Epub 2020 Jul 4.

BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, United Kingdom. Electronic address:

Background: Previous studies suggest an association between short-term exposure to carbon monoxide and myocardial infarction. We performed a systematic review and meta-analysis to assess current evidence on this association to support the update of the World Health Organization (WHO) Global Air Quality Guidelines.

Methods: We searched Medline, Embase and Cochrane Central Register of Controlled Trials to update the evidence published in a previous systematic review up to 30th September 2018 for studies investigating the association between short-term exposure to ambient carbon monoxide (up to lag of seven days) and emergency department visits or hospital admissions and mortality due to myocardial infarction. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105901DOI Listing

Quantification of brain oxygen extraction and metabolism with [O]-gas PET: A technical review in the era of PET/MRI.

Neuroimage 2020 Jul 4:117136. Epub 2020 Jul 4.

Department of Radiology, Stanford University, Stanford CA, USA.

Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO. Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117136DOI Listing

Comparative assessment of in vitro/in vivo performances of orodispersible electrospun and casting films containing rizatriptan benzoate.

Eur J Pharm Biopharm 2020 Jul 4. Epub 2020 Jul 4.

Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road No. 103, Shenyang, China; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen O, Denmark. Electronic address:

The electrospinning process is a promising approach to produce various drug-loaded orodispersible films (ODFs) with a rapid onset of their actions. However, there is only limited number of studies comparing the pharmacological performances of electrospun ODFs (eODFs) with traditional casting films (CFs). In this study, rizatriptan benzoate (RB), a pain relieving agent was formulated with PVP and PVA into ODFs using electrospinning and casting methods. Read More

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http://dx.doi.org/10.1016/j.ejpb.2020.06.023DOI Listing

OCT (optical coherence tomography) contribution assessment in the revascularisation of long femoro-popliteal occlusive lesions (TASC C and D): a randomised trial.

Ann Vasc Surg 2020 Jul 4. Epub 2020 Jul 4.

Vascular Surgery, Institut Cœur-Poumon, CHU Lille. Electronic address:

Background: Endovascular treatment has become the first-line revascularisation technique for femoropopliteal lesions. This technique lacks of reliable and accurate morphological control of the arterial segment treated. Intraoperative 2-D angiogram consumes iodinated contrast media and increases X-ray exposure; this subsequently provides none 3D information on the quality of the revascularisation completed, what could explain some of the early and late failures of the technique. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.06.061DOI Listing

Functional Imaging using Radiomic Features in Assessment of Lymphoma.

Methods 2020 Jul 4. Epub 2020 Jul 4.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.

Lymphomas are typically large, well-defined, and relatively homogeneous tumors, and therefore represent ideal targets for the use of radiomics. Of the available functional imaging tests, [18F]FDG-PET for body lymphoma and diffusion-weighted MRI (DWI) for central nervous system (CNS) lymphoma are of particular interest. The current literature suggests that two main applications for radiomics in lymphoma show promise: differentiation of lymphomas from other tumors, and lymphoma treatment response and outcome prognostication. Read More

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http://dx.doi.org/10.1016/j.ymeth.2020.06.020DOI Listing

RIFM fragrance ingredient safety assessment, 1-(2-methylprop-2-enoloxy)-2,2,4-trimethylpentan-3-ol, CAS Registry Number 526218-21-3.

Food Chem Toxicol 2020 Jul 4:111492. Epub 2020 Jul 4.

Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677,, USA.

The existing information supports the use of this material as described in this safety assessment. 1-(2-Methylprop-2-enoloxy)-2,2,4-trimethylpentan-3-ol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 1-(2-methylprop-2-enoloxy)-2,2,4-trimethylpentan-3-ol is not genotoxic. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111492DOI Listing

RIFM fragrance ingredient safety assessment, 3-(4-methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile, CAS registry number 68084-04-8.

Food Chem Toxicol 2020 Jul 4:111491. Epub 2020 Jul 4.

Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

The existing information supports the use of this material as described in this safety assessment. 3-(4-Methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 3-(4-methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile is not genotoxic. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111491DOI Listing

Blood carbon dioxide tension and risk in pulmonary arterial hypertension.

Int J Cardiol 2020 Jul 4. Epub 2020 Jul 4.

Abteilung für Pneumologie, II. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Background: Low partial pressure of blood carbon dioxide (PCO) is common in patients with pulmonary arterial hypertension (PAH) and may inform on clinical outcomes. We investigated whether PCO measurements could provide prognostic information in addition to standard risk assessment in this group of patients.

Methods: We conducted a retrospective observational cohort study on patients with newly diagnosed idiopathic, heritable or drug/toxin-induced PAH recruited from two European centres. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.069DOI Listing

A review of global health technology assessments of non-VKA oral anticoagulants in non-valvular atrial fibrillation.

Int J Cardiol 2020 Jul 4. Epub 2020 Jul 4.

Center for Public Health Research, IRCCS Multimedica Research Hospital, Sesto San Giovanni, Italy. Electronic address:

Background: This review assessed global health technology assessment (HTA) reports and recommendations of non-vitamin K oral anticoagulants (NOACs) in non-valvular atrial fibrillation (NVAF).

Methods: NHTA agency websites were searched for HTA reports evaluating NOACs versus NOACs or vitamin K antagonists. HTA methods and information on patient involvement/access were collected and empirically analyzed. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.061DOI Listing

Choroidal thickness and ocular growth in childhood.

Surv Ophthalmol 2020 Jul 4. Epub 2020 Jul 4.

2(nd) Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, 56403, Greece. Electronic address:

The involvement of the choroid in ocular growth regulation has been postulated in studies showing that refractive errors correlate with alterations in choroidal thickness (ChT). The advent of optical coherence tomography (OCT) imaging has enabled qualitative and quantitative assessment of the choroid. In children, ChT changes correlate with a number of ocular pathologies, including myopia, retinopathy of prematurity (ROP) and amblyopia. Read More

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http://dx.doi.org/10.1016/j.survophthal.2020.06.008DOI Listing

Efficacy and safety of Sildenafil treatment in pulmonary hypertension caused by chronic obstructive pulmonary disease: A meta-analysis.

Life Sci 2020 Jul 4:118001. Epub 2020 Jul 4.

Department of Respiratory Medicine, Respiratory Diseases Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China. Electronic address:

Aims: Pulmonary hypertension (PH) is a severe and prevalent complication of chronic obstructive pulmonary disease (COPD), with low quality of life and poor prognosis. This study was designed to evaluate the efficacy and safety of Sildenafil in the treatment of PH caused by COPD (COPD-PH) and provide reference for clinical treatment.

Materials And Methods: We systematically searched PubMed, EMBASE, Cochrane Library, Clinical Trials. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118001DOI Listing

EMS Access Constraints And Response Time Delays For Deprived Critically Ill Patients Near Paris, France.

Health Aff (Millwood) 2020 Jul;39(7):1175-1184

Etienne Audureau is a public health physician and scientist with the research team Clinical Epidemiology and Ageing Unit (CEpiA), UPEC.

Increased emergency medical services (EMS) response times and areas of low socioeconomic status are both associated with poorer outcomes for several time-sensitive medical conditions attended to by medical personnel before a patient is hospitalized. We evaluated the association between EMS response times, area deprivation level, and on-scene access constraints encountered by EMS in a large urban area in France. We conducted a multicenter prospective cohort study of EMS dispatches occurring in the forty-seven cities in a region southeast of Paris. Read More

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http://dx.doi.org/10.1377/hlthaff.2019.00842DOI Listing

Translating Frailty Assessment Methodologies and Research-based Evidence to Clinical Education and Practice.

J Aging Soc Policy 2020 Jul 7:1-15. Epub 2020 Jul 7.

Principal Investigator, The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin , Dublin 2, Ireland.

Frailty is a common clinical syndrome that predisposes older adults to an increased risk of adverse health outcomes. With population aging, this will become an increasing challenge for the healthcare services; therefore, different models of healthcare training and provision are required to address these increasing demands. In Ireland, the National Clinical Programme for Older People (NCPOP) has partnered with The Irish Longitudinal Study on Ageing (TILDA) to deliver the National Frailty Education Programme. Read More

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http://dx.doi.org/10.1080/08959420.2020.1777825DOI Listing

A study on clinical outcomes of combination of terlipressin and albumin in Hepatorenal Syndrome.

Scand J Gastroenterol 2020 Jul 7:1-5. Epub 2020 Jul 7.

Department of GI surgery, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Background: Hepatorenal Syndrome (HRS) is a reversible functional renal impairment that occurs in patients with advanced liver cirrhosis or those with fulminant hepatic failure.

Aim: To evaluate the effect of terlipressin and albumin combination in various clinical outcomes in Hepatorenal Syndrome patients It was a prospective study involving 50 patients with HRS. The effectiveness parameters of the treatments were: confirmed HRS reversal, Recurrence of HRS within 90 days of treatment and mortality rate up to 90 days. Read More

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http://dx.doi.org/10.1080/00365521.2020.1786851DOI Listing

Electrocardiogram Standards for Children and Young Adults Using Z-scores.

Circ Arrhythm Electrophysiol 2020 Jul 7. Epub 2020 Jul 7.

Rady Children's Hospital San Diego & University of California San Diego, Department of Pediatrics, San Diego, CA.

- Normative ECG values for children are based on relatively few subjects and are not standardized, resulting in interpersonal variability of interpretation. Recent advances in digital technology allow a more quantitative, reproducible assessment of ECG variables. Our objective was to create the foundation of normative ECG standards in the young utilizing Z-scores. Read More

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http://dx.doi.org/10.1161/CIRCEP.119.008253DOI Listing

Constructing Approaches to Entrustable Professional Activity Development that Deliver Valid Descriptions of Professional Practice.

Teach Learn Med 2020 Jul 7:1-9. Epub 2020 Jul 7.

Center for Research and Development of Education, University Medical Center Utrecht, Utrecht, The Netherlands.

Entrustable Professional Activities (EPAs) describe the core tasks health professionals must be competent performing prior to promotion and/or moving into unsupervised practice. When used for learner assessment, they serve as gateways to increased responsibility and autonomy. It follows that identifying and describing EPAs is a high-stakes form of work analysis aiming to describe the core work of a profession. Read More

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http://dx.doi.org/10.1080/10401334.2020.1784740DOI Listing

A new dimension in patent foramen ovale size estimation.

Echocardiography 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatric Cardiology, Ghent University Hospital, Ghent, Belgium.

Background: Detailed multidimensional assessment of patent foramen ovale (PFO) size with transesophageal echocardiography (TOE) may help to determine PFO pathogenicity in cryptogenic stroke patients. We explored the potential additive value of Live xPlane and three-dimensional (3D) TOE anatomical PFO sizing techniques.

Methods: Imaging data of 45 patients who underwent a 3D TOE-assisted percutaneous PFO closure were studied. Read More

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http://dx.doi.org/10.1111/echo.14696DOI Listing

Evaluation of 2-Hour Post-Dose Efficacy of Lasmiditan for the Acute Treatment of Difficult-to-Treat Migraine Attacks.

Headache 2020 Jul 7. Epub 2020 Jul 7.

Eli Lilly and Company, Kobe, Japan.

Objective: To identify factors predicting response (2-hour headache pain freedom or most bothersome symptom freedom) to lasmiditan based on individual patient characteristics, migraine disease characteristics, and migraine attack characteristics. Further, efficacy specifically in difficult-to-treat patient/migraine disease characteristics or attack characteristics (ie, historically considered less responsive to certain acute therapies) subgroups was analyzed.

Background: Knowledge of factors associated with a positive or negative response to acute treatment would be useful to practitioners prescribing acute treatments for migraine. Read More

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http://dx.doi.org/10.1111/head.13897DOI Listing

Crown preparations by undergraduate dental students: A comparison of conventional versus digital assessment via an intraoral scanner.

J Dent Educ 2020 Jul 7. Epub 2020 Jul 7.

Faculty of Dentistry, National University of Singapore, Singapore, Republic of Singapore.

Purpose: This study aims to assess the effectiveness of the 3Shape TRIOS intraoral scanner (IOS) in student crown preparation evaluation.

Design: Students were tasked to perform a full metal crown preparation on the upper left first molar on a patient simulator within 45 minutes. Marginal Width, Occlusal Reduction, Presence of Undercuts, Taper, Planes of Reduction, Line Angles, Conformity to Gingival Contour, and Smoothness were evaluated via 3 assessment modes: (a) Conventional assessment by 2 supervisors; (b) Conventional assessment by students; (c) Digital assessment by students. Read More

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http://dx.doi.org/10.1002/jdd.12285DOI Listing

Safety and efficacy of the combination of sonidegib and ruxolitinib in myelofibrosis: a phase 1b/2 dose-finding study.

Blood Adv 2020 Jul;4(13):3063-3071

Guy's and St Thomas' National Health Service Foundation Trust, Guy's Hospital, London, United Kingdom.

The sonidegib and ruxolitinib combination was assessed in an open-label study in JAK inhibitor-naive patients with myelofibrosis (MF). The primary objective of phase 1b was to establish the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) and phase 2 was to assess spleen volume reduction at weeks 24 and 48. Fifty patients were enrolled. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001212DOI Listing

Clinical Practice of Adalimumab and Infliximab Biosimilar Treatment in Adult Patients With Crohn's Disease.

Inflamm Bowel Dis 2020 Jul 7. Epub 2020 Jul 7.

IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy.

The introduction of tumor necrosis factor (TNF) inhibitors has significantly changed the treatment landscape in Crohn's disease (CD). The overall therapeutic achievements with TNF inhibitors such as infliximab, adalimumab, and certolizumab pegol paved the way to push the boundaries of treatment goals beyond symptomatic relief and toward cessation of objective signs of inflammation, including endoscopic remission. Even though these agents are widely used for the treatment of moderate to severe CD, heterogeneity still exists in translating evidence-based guidelines on the use of anti-TNF agents into actual treatment algorithms in CD. Read More

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http://dx.doi.org/10.1093/ibd/izaa078DOI Listing

Prevalence of depressive symptoms among nurses in China: A systematic review and meta-analysis.

PLoS One 2020 7;15(7):e0235448. Epub 2020 Jul 7.

Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, People's Republic of China.

Background: Depression is one of the most common mental disorders, profoundly impacting an individual's performance and quality of life. Due to their unique working conditions, nursing is counted among the occupational groups at high risk for developing depression. Because of the shortage of nursing resources in China, Chinese nurses suffer from heavy daily workloads more than those in many other countries. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235448PLOS

C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.

JCI Insight 2020 Jul 7. Epub 2020 Jul 7.

Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

Critical illness is accompanied by the release of large amounts of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of neutrophils which is associated with adverse outcomes. The signalling pathways that mediate C5a-induced neutrophil dysfunction are incompletely understood. Read More

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http://dx.doi.org/10.1172/jci.insight.137029DOI Listing

Management and Treatment of Concussions via Tele-concussion in a Pediatric Setting: A Methodological Approach and Descriptive Analysis.

JMIR Pediatr Parent 2020 Jul 6. Epub 2020 Jul 6.

Children's Health Andrew's Insitute, Unit T12007211 Preston RD, Plano, US.

Background: Approximately 2.0 million children in the United States sustain a concussion annually, resulting in an economic impact as high as $20 billion. Patients who receive treatment at concussion specialty clinics, versus primary care, experience faster recovery, thereby reducing patient burden and subsequent medical related costs. Read More

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http://dx.doi.org/10.2196/19924DOI Listing

Characterization of Differences in the Time Course of Reflex and Voluntary Responses Following Botulinum Toxin Injections in Chronic Stroke Survivors.

IEEE Trans Neural Syst Rehabil Eng 2020 Jul;28(7):1642-1650

Spasticity is a major impairment that can occur following a hemispheric stroke and is often treated with injections of botulinum toxin, a neurotoxin that impairs transmission at the neuromuscular junction. Hyperreflexia is a defining feature of spasticity. Our main objective here was to quantify the time course of changes in the deep tendon reflex (DTR) responses and voluntary activation capacity following BT injection as well as to track changes in a clinical assessment of spasticity. Read More

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http://dx.doi.org/10.1109/TNSRE.2020.2997213DOI Listing

Hand Kinematics Characterization While Performing Activities of Daily Living Through Kinematics Reduction.

IEEE Trans Neural Syst Rehabil Eng 2020 Jul;28(7):1556-1565

Improving the understanding of hand kinematics during the performance of activities of daily living may help improve the control of hand prostheses and hand function assessment. This work identifies sparse synergies (each degree of freedom is present mainly in only one synergy), representative of the global population, with emphasis in unveiling the coordination of joints with small range of motion (palmar arching and fingers abduction). The study is the most complete study described in the literature till now, involving 22 healthy subjects and 26 representative day-to-day life activities. Read More

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http://dx.doi.org/10.1109/TNSRE.2020.2998642DOI Listing

Current assessment and management of endoleaks after advanced EVAR: new devices, new endoleaks?

Expert Rev Cardiovasc Ther 2020 Jul 7. Epub 2020 Jul 7.

Vascular and Interventional Unit, Department of Radiological Sciences, Policlinico Umberto I, "Sapienza" University of Rome , Rome, Italy.

Introduction In recent years there has been an increasing application of advanced EVAR techniques to tackle complex clinical and anatomical scenarios. In a bid to overcome the limitations of the traditional stent-grafts, newer EVAR endografts and techniques have been developed and introduced into clinical practice, permitting endovascular management of difficult infrarenal, juxta-renal and thoracoabdominal aneurysms for which previously there was no endovascular solution. As a consequence, we are now confronted with unique patterns of endoleak requiring customised clinical-radiological assessment and treatment. Read More

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http://dx.doi.org/10.1080/14779072.2020.1792294DOI Listing

Entropy Fit Indices: New Fit Measures for Assessing the Structure and Dimensionality of Multiple Latent Variables.

Multivariate Behav Res 2020 Jul 7:1-29. Epub 2020 Jul 7.

Department of Psychology, University of Virginia.

The accurate identification of the content and number of latent factors underlying multivariate data is an important endeavor in many areas of Psychology and related fields. Recently, a new dimensionality assessment technique based on network psychometrics was proposed (Exploratory Graph Analysis, EGA), but a measure to check the fit of the dimensionality structure to the data estimated via EGA is still lacking. Although traditional factor-analytic fit measures are widespread, recent research has identified limitations for their effectiveness in categorical variables. Read More

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http://dx.doi.org/10.1080/00273171.2020.1779642DOI Listing

Association between Characteristics of Impostor Phenomenon in Medical Students and Step 1 Performance.

Teach Learn Med 2020 Jul 7:1-13. Epub 2020 Jul 7.

Undergraduate Medical Education, University of Louisville, Louisville, Kentucky, USA.

: Impostor phenomenon (IP) is a widely recognized experience in which highly performing individuals do not internalize success. Self-doubt toward one's ability or intelligence is unexpectedly common. Prior research has associated IP with medical student perceptions, burnout, and demographic characteristics. Read More

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http://dx.doi.org/10.1080/10401334.2020.1784741DOI Listing
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