1,265,948 results match your criteria Assessment & Evaluation In Higher Education[Journal]


Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

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http://doi.wiley.com/10.1002/14651858.CD011875.pub2
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http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
April 2019
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Optimization of Whole-Body CT Examinations of Polytrauma Patients in Comparison with the Current Diagnostic Reference Levels.

Rofo 2019 Apr 18. Epub 2019 Apr 18.

Department of Diagnostic and Interventional Radiology, University-Hospital Giessen, Justus-Liebig-University Giessen, Germany.

Purpose:  Evaluation of the dose values of a polytrauma whole-body CT examination used in clinical practice with regard to the 2016 updated diagnostic reference levels and reduction of the mean exposure levels using simple optimization steps.

Materials And Methods:  In each case, 100 exposure values before and after dose optimization were compared with the old and new diagnostic reference levels. The grayscale values and the signal-to-noise ratio (SNR) were determined for the lung, the aortic arch and the liver. Read More

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http://dx.doi.org/10.1055/a-0881-3113DOI Listing

[Pupil disorders].

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

The evaluation of pupillary function is a keystone in the neuro-ophthalmic assessment of patients. The diagnosis of an afferent or efferent pupillary disorder is crucial in the acquisition of a broad range of diseases of the brain or the peripheral nervous system. This "update" of pupillary disorders covers a major part of clinical conditions eye doctors have to expect in their daily practice. Read More

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http://dx.doi.org/10.1055/a-0885-2467DOI Listing

[Basics for the Preparation of an Ophthalmological Expert Assessment].

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

The position of the ophthalmologist as an unbiased and impartial expert in the field of tension between the client and the patient is a responsible task that should not be underestimated. Since the ophthalmological expert assessment often has far-reaching legal and financial consequences, it is very important that it is both formally correct and of high quality. Unfortunately, it is becoming increasingly common to find that the examinations required for the preparation of an expert opinion are not carried out optimally, that findings are not substantiated or that formalities are not adhered to correctly. Read More

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http://dx.doi.org/10.1055/a-0889-9523DOI Listing

The Assessment of Blood Flow Velocities in Retinal Collaterals in Diabetic Retinopathy.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):530-535. Epub 2019 Apr 18.

Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.

Purpose: Diabetic retinopathy (DR) is a microvascular disease characterized by capillary dropout and resultant retinal ischemia which then leads to retinal vascular remodeling. Our goal was to assess blood flow velocities in retinal collateral vessels in healthy and diabetic subjects with various stages of DR.

Methods: In our pilot study, we enrolled five eyes of five healthy subjects (H), five eyes of four subjects with diabetes and no retinopathy (DM), three eyes of three subjects with mild non-proliferative diabetic retinopathy (MDR), and five eyes of four subjects with proliferative diabetic retinopathy (PDR). Read More

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http://dx.doi.org/10.1055/a-0861-9675DOI Listing

Encephalopathy in neonates with subgaleal hemorrhage is a key predictor of outcome.

Pediatr Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Objective: Subgaleal hemorrhage (SGH) is reported to be associated with severe hemodynamic instability, coagulopathy, and even mortality. The importance of the presence or absence of neonatal encephalopathy in predicting SGH outcomes has not been explored. The aim of this study was to determine the relationship of clinical encephalopathy to short-term outcomes in neonates with SGH. Read More

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http://www.nature.com/articles/s41390-019-0400-1
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http://dx.doi.org/10.1038/s41390-019-0400-1DOI Listing
April 2019
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The Mealtime Assessment Scale (MAS): Part 1 - Development of a Scale for Meal Assessment.

Folia Phoniatr Logop 2019 Apr 18:1-13. Epub 2019 Apr 18.

Department of Biomedical and Clinical Sciences "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Aims: Safety and efficacy of swallowing in instrumental assessment may not overlap safety and efficacy of swallowing during meal, as personal and environmental factors can influence the performance. This study aims to develop a scale to assess the safety and efficacy of swallowing during meal.

Methods: A working group discussed the latent construct, target population, and purposes of the scale. Read More

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https://www.karger.com/Article/FullText/494135
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http://dx.doi.org/10.1159/000494135DOI Listing
April 2019
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Assessment of Intermittent Self-Catheterization Procedures in Patients with Neurogenic Lower Urinary Tract Dysfunction: Dutch Translation and Validation of the Intermittent Catheterization Satisfaction Questionnaire, Intermittent Catheterization Acceptance Test, Intermittent Self Catheterization Questionnaire and Intermittent Catheterization Difficulty Questionnaire.

Urol Int 2019 Apr 18:1-6. Epub 2019 Apr 18.

Department of Urology, Ghent University Hospital, Ghent, Belgium.

Background: Intermittent self-catheterization (ISC) is by far the most appealing therapy to achieve a complete bladder emptying in patients with neurogenic lower urinary tract dysfunction (NLUTD). Four questionnaires have been developed in French in order to assess patient's satisfaction, difficulties and acceptance of this technique.

Objectives: The aim of this study was to translate, culturally adapt and validate Dutch versions of the Intermittent Catheterization Satisfaction Questionnaire (InCaSaQ), the Intermittent Catheterization Acceptance Test (ICAT), the Intermittent Self Catheterization Questionnaire (ISCQ) and the Intermittent Catheterization Difficulty Questionnaire (ICDQ). Read More

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http://dx.doi.org/10.1159/000499884DOI Listing

Effects of the Narrative Intervention Program for Preschool Portuguese Children.

Folia Phoniatr Logop 2019 Apr 18:1-7. Epub 2019 Apr 18.

CINTESIS.UA - Center for Health Technology and Services Research (UID/IC/04255/2013) and School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal,

Objective: This article analyzes the contribution of a narrative intervention program in linguistic performance (measured by the percentage of correct consonants [PCC], mean length of utterance [MLU], and auditory memory [AM]) of children.

Patients And Methods: A group of 14 children with primary language impairments participated in this study. The children were divided into two groups (seven children in each): the narrative intervention group (experimental group) and the control group. Read More

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http://dx.doi.org/10.1159/000496793DOI Listing

Non-invasive imaging methodologies for assessment of radiation damage to bone marrow and kidneys from peptide receptor radionuclide therapy.

Neuroendocrinology 2019 Apr 19. Epub 2019 Apr 19.


Background/Aims: Peptide receptor radionuclide therapy (PRRT) is becoming clinical routine for management of Neuroendocrine Tumours. The number of PRRT cycles are correlated with treatment effect but theoretically limited by off-target radiation damage to kidneys and bone marrow. New imaging biomarkers for assessment of PRRT tissue damage would enable evaluation of novel renal and bone marrow protective agents, as well as personalized PRRT treatment regiments. Read More

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http://dx.doi.org/10.1159/000500473DOI Listing

The Impact of Using Emotionally Arousing Stimuli on Muscle Response Testing Accuracy.

Complement Med Res 2019 Apr 18:1-9. Epub 2019 Apr 18.

School of Health Sciences, City University London, London, United Kingdom.

Introduction: Muscle response testing (MRT) is an assessment method used by 1 million practitioners worldwide, yet its usefulness remains uncertain. The aim of this study, one in a series assessing the accuracy of MRT, was to determine whether emotionally arousing stimuli influence its accuracy compared to neutral stimuli.

Methods: To assess diagnostic test accuracy 20 MRT practitioners were paired with 20 test patients (TPs). Read More

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https://www.karger.com/Article/FullText/497188
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http://dx.doi.org/10.1159/000497188DOI Listing
April 2019
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Overview of bioremediation with technology assessment and emphasis on fungal bioremediation of oil contaminated soils.

J Environ Manage 2019 Apr 15;241:156-166. Epub 2019 Apr 15.

PROFNIT - Professional Post-Graduate Program in Intellectual Property and Technology Transfer for Innovation, Federal University of Bahia, Campus de Ondina, R. Barão de Jeremoabo, 147, Ondina, Salvador, BA, 40170-115, Brazil; José de Anchieta College, Av. João Durval Carneiro, n. 3039, São João, Feira de Santana, BA, 44051-605, Brazil. Electronic address:

Environmental contamination is a problem that requires sustainable solutions. Bioremediation technologies have been developed in the last decades and are increasingly used to mitigate environmental accidents and systematic contaminations. A review of bioremediation technologies, based on published article and patent documents, is presented for different types of contaminated matrices, bioremediation agents and contaminants. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.019DOI Listing

Thermo-ecological analysis of industrial kilns.

J Environ Manage 2019 Apr 15;241:149-155. Epub 2019 Apr 15.

Department of Mechanical Engineering, Faculty of Engineering, Usak University, 64200, Usak, Turkey. Electronic address:

In this study, thermo-ecological analysis has been applied by using ecologic objective function "ECO" and ecological coefficient of performance "ECOP" to the kilns used in the firing process of the ceramic plant. Five different environmental (dead state) temperatures (between 10 °C and 30 °C) are taken into account. The irreversibility, which are the most important criteria affecting ecological performance, occurs during the heat transfer in the burners and cooling in the kiln. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.032DOI Listing

A method for the cell-cycle-specific analysis of radiation-induced chromosome aberrations and breaks.

Mutat Res 2019 Apr 6;815:10-19. Epub 2019 Apr 6.

Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, Essen, Germany. Electronic address:

The classical G-assay is widely used to assess cell-radiosensitivity and cancer phenotype: Cells are exposed to low doses of ionizing-radiation (IR) and collected for cytogenetic- analysis ˜1.5 h later. In this way, chromosome-damage is measured in cells irradiated in G-phase, without retrieving information regarding kinetics of chromosome-break-repair. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00275107193003
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http://dx.doi.org/10.1016/j.mrfmmm.2019.04.001DOI Listing
April 2019
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G-quadruplex and duplex DNA binding studies of novel Ruthenium(II) complexes containing ascididemin ligands.

J Inorg Biochem 2019 Apr 6;196:110681. Epub 2019 Apr 6.

Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200092, PR China. Electronic address:

In this paper, three new Ruthenium(II) polypyridyl complexes containing ascididemin (ASC) as main ligand have been synthesized and characterized. Their interactions with different G-quadruplex (Htelo, c-myc and c-kit) (Htelo: human telomeric DNA, c-myc: cellular-myelocytomatosis viral oncogene, c-kit: oncogene c-kit promoter sequences) and duplex (ds26) DNA sequences were comparatively studied with the free ligand ASC by a series of spectroscopic techniques including UV-vis (ultraviolet-visible) spectroscopy, FID (fluorescent intercalator displacement) assay, and FRET (fluorescence resonance energy transfer) melting assay. Molecular docking studies were also performed to support the binding mode of the compounds with G-quadruplex DNA. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.021DOI Listing

Bioavailable Sr/Sr in European soils: A baseline for provenancing studies.

Sci Total Environ 2019 Mar 31;672:1033-1044. Epub 2019 Mar 31.

Eurogeosurveys, Brussels, Belgium.

We present Sr/Sr isotope ratios for ~1200 selected soil samples, collected by the GEMAS consortium from grazing (Gr) and agricultural (Ap) soils in Europe with the aim to better understand the strontium isotope distribution in the bioavailable fraction of the top-soil and its potential for provenancing applications. Spatial analysis shows that there is a clear distinction between coastal (<100 km) and non-coastal (>100 km) samples in their variance and that this variance is mirrored in the sodium concentration, suggesting an important but highly variable contribution from seaspray. We present two Sr/Sr maps at 25 km × 25 km scale: one based solely on the measured data using a classical kriging approach and one based on a Random Forest model using complementary GEMAS data to predict the strontium isotope composition at the remaining 3000+ GEMAS sampling locations, including appropriate uncertainty assessment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193138
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http://dx.doi.org/10.1016/j.scitotenv.2019.03.387DOI Listing
March 2019
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Exposure assessment of cyclists to UFP and PM on urban routes in Xi'an, China.

Environ Pollut 2019 Apr 7;250:241-250. Epub 2019 Apr 7.

School of Automobile, Chang'an University, Chang'an Road, Xi'an, 710064, Shaanxi, China. Electronic address:

With the promotion of bicycle sharing, cycling as an active transportation mode is a matter of public interest. However, cyclists' recurrent exposure to traffic-related air pollution is associated with the potential health risks. Quantification of the health risks associated with daily exposure of commuting cyclists to atmospheric pollutants is vital, but barely reported. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.129DOI Listing
April 2019
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The three 'B' of fish mercury in China: Bioaccumulation, biodynamics and biotransformation.

Environ Pollut 2019 Apr 10;250:216-232. Epub 2019 Apr 10.

Department of Ocean Science, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, HKUST Shenzhen Research Institute, Shenzhen, 518057, China. Electronic address:

Mercury (Hg) is a global toxic pollutant and has raised the world's attention for decades. In this study, we reviewed the fish mercury levels in China (both marine and freshwater, as well as wild and farmed) documented over the past decade and their controlling environmental and biological factors. China is the largest contributor of global Hg cycling and the largest nation for the consumption and export of fish and fish product, thus Hg level in fish becomes a critical issue for food safety and public health. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.034DOI Listing
April 2019
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Seasonal variations of NPAHs and OPAHs in PM at heavily polluted urban and suburban sites in North China: Concentrations, molecular compositions, cancer risk assessments and sources.

Ecotoxicol Environ Saf 2019 Apr 15;178:58-65. Epub 2019 Apr 15.

Environment Research Institute, Shandong University, Qingdao, Shandong 266237, China.

16 nitrated polycyclic aromatic hydrocarbons (NPAHs) and 5 oxygenated polycyclic aromatic hydrocarbons (OPAHs) in PM at two locations in Northern China were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). Sampling was conducted at an urban site in Shandong University in Jinan (SDU) and a suburban site in Qixingtai in Jinan (QXT) in March, June, September and December in 2016. Overall, the concentrations of NPAHs and OPAHs were higher at SDU (1. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.009DOI Listing

The choreography of chemicals in nature; beyond ecotoxicological limits.

Authors:
Martina G Vijver

Chemosphere 2019 Apr 10;227:366-370. Epub 2019 Apr 10.

Leiden Universiteit, Institute for Environmental Sciences, PO Box 9518, 2300, RA Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.068DOI Listing

Association between methylation of DNA damage response-related genes and DNA damage in hepatocytes of rats following subchronic exposure to vinyl chloride.

Chemosphere 2019 Apr 9;227:323-328. Epub 2019 Apr 9.

Department of Statistics, School of Public Health, Shanxi Medical University, Taiyuan, China.

In the present study, we investigated the association between methylation of DNA damage response-related genes such as cyclin-dependent kinase inhibitor (CDKN)2A, Ras association (RalGDS/AF-6) domain family member (RASSF)1A, O6-methylguanine DNA methyltransferase (MGMT), Kirsten rat sarcoma viral oncogene homolog (KRAS), and spleen-associated tyrosine kinase (SYK) and DNA damage in hepatocytes of rats following subchronic exposure to vinyl chloride (VC). Sixty-four healthy rats were randomly divided into three VC exposure groups (5, 25, and 125 mg/kg) and an untreated negative control group (n = 16 each). VC was administered by intraperitoneal injection every other day for a total of three times a week. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.058DOI Listing

Establishing treatment optimisation as part of personalised medicine development.

Eur J Cancer 2019 Apr 15;113:96-97. Epub 2019 Apr 15.

Member of the European Parliament, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ejca.2019.03.014DOI Listing

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test.

Arch Gerontol Geriatr 2019 Apr 1;83:114-120. Epub 2019 Apr 1.

Department of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University of Madrid, Spain.

Alzheimer's disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674943193008
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http://dx.doi.org/10.1016/j.archger.2019.03.025DOI Listing
April 2019
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Formulation, clinical and histopathological assessment of microemulsion based hydrogel for UV protection of skin.

Colloids Surf B Biointerfaces 2019 Apr 8;179:393-404. Epub 2019 Apr 8.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, P.O. Box: 91388-13944, Islamic Republic of Iran.

The aim of this study was to prepare a microemulsion based hydrogel containing sesame oil and evaluate its topical application in preventing the harmful effects of UV radiation on the guinea pig's skin using histopathologic and clinical findings. Sesame oil with high antioxidant content and unique chemical and physiological properties is a suitable candidate for the evolution of UV protection on skin. Applying this natural oil in microemulsion formulation containing particles with nanometer size can enhance its efficacy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.015DOI Listing

Detecting pathological complete response in esophageal cancer after neoadjuvant therapy based on imaging techniques: a diagnostic systematic review and meta-analysis.

J Thorac Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of surgery.

Background: Up to 32% of patients with esophageal cancer show a pathological complete response (ypCR) after neoadjuvant therapy. In order to prevent overtreatment, the indication to perform esophagectomy in these patients should be reconsidered. Implementing an organ preserving strategy for patients with ypCR requires an accurate assessment of residual disease after neoadjuvant treatment. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.04.004DOI Listing

A life cycle scenario analysis of different pavement technologies for urban roads.

Sci Total Environ 2019 Apr 5;673:585-593. Epub 2019 Apr 5.

University Mediterranea of Reggio Calabria, Department of Information, Infrastructure and Sustainable Energy (DIIES), Via Graziella, Feo di Vito, 89214 Reggio Calabria, Italy.

In the past, lowest price was the award criterion, given that structural capacity and safety were assured. In the last years, environmental, energy, and long-term impacts have been introduced (climate change, resource depletion, energy consumption, generated solid waste, discharged water, and emissions). Unfortunately, the introduction of new pavement technologies and materials (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193156
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.046DOI Listing
April 2019
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Saving inventory - Revised: Psychometric performance across the lifespan.

J Affect Disord 2019 Apr 8;252:358-364. Epub 2019 Apr 8.

University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, BC V6T 1Z4 Canada.

Background: The Saving Inventory - Revised (SI-R) is the most widely used self-report measure of hoarding symptom severity. The goal of this study is to establish a firm empirical basis for a cutoff score on the SI-R and to examine the functioning of the SI-R as a screening tool and indicator of hoarding symptom severity across the lifespan.

Methods: This study used archival data from 1,116 participants diagnosed with a clinical interview in 14 studies conducted by research groups who focus on hoarding. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.007DOI Listing

De-escalation of complexity in oncoplastic breast surgery: Case series from a specialized breast center.

Breast 2019 Apr 9;46:12-18. Epub 2019 Apr 9.

Multidisciplinary Breast Unit, Azienda Ospedaliera Cannizzaro, Catania, Italy.

Introduction: Oncoplastic breast surgery has evolved the surgical treatment of breast cancer over the past two decades. This practice still lacks validation and poses several dilemmas in terms of safety, local and systemic control, timing of adjuvant treatments and cost-effectiveness. Our case series investigates the effects of a reduced surgical complexity on cosmetic results and quality of life. Read More

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http://dx.doi.org/10.1016/j.breast.2019.04.002DOI Listing

Periodontal condition of patients with Thalassemia Major: A systematic review and meta-analysis.

Arch Oral Biol 2019 Apr 9;102:113-121. Epub 2019 Apr 9.

Department of Periodontology, School of Dentistry, Faculty of Health, Witten/Herdecke University, Witten, Germany.

Objectives: The aim of this systematic review was to evaluate the existing evidence on the association between Thalassemia major (TM) and periodontal condition.

Materials & Methods: MEDLINE via OVID, EMBASE, and The Cochrane Database (including the Central Register of Controlled Trials (CENTER)), were searched up to September 2018 to identify observational studies eligible for systematic review and meta-analyses. Newcastle-Ottawa Scale (NOS) was used for quality assessment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183090
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http://dx.doi.org/10.1016/j.archoralbio.2019.04.004DOI Listing
April 2019
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Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform.

J Pharmacol Toxicol Methods 2019 Apr 15. Epub 2019 Apr 15.

Drug Safety Research and Development, Pfizer Inc., La Jolla, CA 92121, United States of America.

Introduction: High throughput in vitro profiling of the cardiac Nav1.5 peak sodium current (I) is widely used in cardiac safety screening. However, there is no standardized high throughput method to measure late I. Read More

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http://dx.doi.org/10.1016/j.vascn.2019.04.001DOI Listing

Anti-obesity effect of argel (Solenostemma argel) on obese rats fed a high fat diet.

J Ethnopharmacol 2019 Apr 15:111893. Epub 2019 Apr 15.

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt. Electronic address:

Ethnopharmacological Relevance: Solenostemma argel (Argel) is a desert plant commonly used in Egyptian and Sudanese traditional medicine to suppress appetite, for treatment of diabetes, and as antispasmodic and anti-inflammatory agents. Previously the anti-diabetic, hypolipidemic and lipase inhibitory activities of Argel were reported in animal studies and in-vitro assays. However, its specific mechanism of action as an anti-obesity agent has not been studied before. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183492
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http://dx.doi.org/10.1016/j.jep.2019.111893DOI Listing
April 2019
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Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients with Alcohol-Associated Hepatitis.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Massachusetts General Hospital, Institute for Technology Assessment, Harvard Medical School, Boston, MA, USA. Electronic address:

Background & Aims: Early liver transplantation (without requiring a minimum period of sobriety) for severe alcohol-associated hepatitis (AH) is controversial-many centers delay eligibility until a specific period of sobriety (such as 6 months) has been achieved. To inform ongoing debate and policy, we modeled long-term outcomes of early vs delayed liver transplantation for patients with AH.

Methods: We developed a mathematical model to simulate early vs delayed liver transplantation for patients with severe AH and different amounts of alcohol use after transplantation: abstinence, slip (alcohol use followed by sobriety), or sustained use. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.012DOI Listing
April 2019
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Radiation-Induced Lung Injury: Assessment and Management.

Chest 2019 Apr 15. Epub 2019 Apr 15.

Department of Radiation Oncology, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston TX, USA.

Radiation-induced lung injury (RILI) encompasses any lung toxicity induced by radiation therapy (RT) and manifests acutely as radiation pneumonitis (RP) and chronically as radiation pulmonary fibrosis (RPF). Since most patients with thoracic and breast malignancies are expected to undergo RT in their lifetime, many with curative intent, the population at risk is significant. Further, indications for thoracic RT are expanding given the advent of stereotactic body radiation therapy or stereotactic ablative radiotherapy (SBRT/SABR) for early stage lung cancer in non-surgical candidates as well as oligometastatic pulmonary disease from any solid tumor. Read More

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http://dx.doi.org/10.1016/j.chest.2019.03.033DOI Listing

Ductal stenting to retrain the involuted left ventricle in d-transposition of the great arteries.

Ann Thorac Surg 2019 Apr 15. Epub 2019 Apr 15.

Paediatric & Congenital Heart Centre, Institut Jantung Negara (National Heart Institute), Kuala Lumpur, Malaysia.

Background: Ductal stenting is performed to retrain involuted left ventricles (LV) in patients with d-transposition of the great arteries and intact ventricular septum (TGA-IVS). However, its efficacy is largely unknown. This study aimed to determine the safety and efficacy of ductal stenting in retraining of involuted LV in patients with TGA-IVS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193055
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http://dx.doi.org/10.1016/j.athoracsur.2019.03.045DOI Listing
April 2019
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Development and preliminary testing of an online software system to facilitate assessment of accuracy and consistency in applying the Australasian Triage Scale.

Australas Emerg Care 2018 Nov 16;21(4):150-158. Epub 2018 Oct 16.

Prince of Wales Hospital Emergency Department, Barker Street, Sydney, Australia.

Purpose: The aim of this project was to design and evaluate an online software system to facilitate the assessment of triage decision accuracy and consistency in applying the Australasian Triage Scale.

Background: Triage is a critical component of emergency nursing practice, which affects patient access to emergency care. Accurate and consistent triage decisions are vital to ensuring patient safety, timely access to care and ED operation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2588994X183004
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http://dx.doi.org/10.1016/j.auec.2018.10.001DOI Listing
November 2018
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Pragmatic evaluation of an observational pain assessment scale in the emergency department: The Pain Assessment in Advanced Dementia (PAINAD) scale.

Australas Emerg Care 2018 Nov 27;21(4):131-136. Epub 2018 Sep 27.

Faculty of Health University of Technology Sydney, Ultimo, NSW 2007, Australia; Research and Practice Development Unit, Level 7, Kolling Building, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW 2065, Australia.

Background: Pain assessment is challenging in older people with cognitive impairment who present to the emergency department and may result in suboptimal management. Therefore, the usefulness of the Pain Assessment in Advanced Dementia (PAINAD) tool for older people with cognitive impairment presenting with a painful injury was evaluated.

Methods: In this multi-centre observational sub-study, older people (≥65 years) suspected of a long bone fracture were screened for cognitive impairment using the Six Item Screening (SIS) tool. Read More

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http://dx.doi.org/10.1016/j.auec.2018.09.001DOI Listing
November 2018

A Retrospective Study Investigating: Factors associated with mode of arrival and emergency department management for patients with acute stroke.

Australas Emerg Care 2018 Aug 17;21(3):99-104. Epub 2018 Aug 17.

University of Melbourne, Department of Medicine, Australia; Royal Melbourne Hospital, Emergency Department, Australia. Electronic address:

Background: Presentation by ambulance to the emergency department is critical for stroke patients to receive time dependent treatments. However, little is known of the factors that influence presentation by ambulance.

Methods: Retrospective analysis of all patients with an emergency department medical diagnosis of stroke who presented to one of three Victorian emergency departments over a three-year period (2011-2013). Read More

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http://dx.doi.org/10.1016/j.auec.2018.07.001DOI Listing

Do consumers who identify as Muslim experience culturally safe care (CSC) in the Emergency Department (ED)? A scoping review.

Australas Emerg Care 2018 Aug 1;21(3):93-98. Epub 2018 Sep 1.

School of Nursing, Midwifery and Paramedicine, Faculty of Health, University of Sunshine Coast, Maroochydore DC 4558, Queensland, Australia.

Lack of awareness about cultural and religious values and beliefs of patients presenting to Emergency Departments (ED) can compromise patient care and safety. Muslim Australians represent the fastest growing religious demographic group, with over a 77% growth in the last decade. The changing face of the Australian population requires that Australian health care carefully consider the dominant Western cultural paradigm currently influencing health care delivery. Read More

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http://dx.doi.org/10.1016/j.auec.2018.08.001DOI Listing

Does an assessment aid improve Glasgow Coma Scale scoring by helicopter rescuers in Hong Kong: A randomised controlled trial.

Australas Emerg Care 2018 Aug 25;21(3):105-110. Epub 2018 Jun 25.

Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Hong Kong Special Administrative Region.

Background: Glasgow Coma Scale (GCS) is one of the most commonly used patient assessment tools. This study aimed to determine whether an assessment aid can improve the GCS scoring accuracy by helicopter rescuers in Hong Kong.

Methods: In this randomised controlled trial, Air Crewman Officers (ACMOs) of Government Flying Service in Hong Kong were randomised into two groups, with and without assessment aid. Read More

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http://dx.doi.org/10.1016/j.auec.2018.06.001DOI Listing

Incidence, characteristics and outcomes of patients that return to Emergency Departments. An integrative review.

Australas Emerg Care 2019 Mar 6;22(1):47-68. Epub 2019 Jan 6.

Susan Wakil School of Nursing, Midwifery, University of Sydney, Australia; Illawarra Shoalhaven Local Health District, NSW, Australia.

Background: Unplanned return visits account for up to 5% of Emergency Department presentations in Australia and have been associated with adverse events and increased costs. A large number of studies examine the incidence, characteristics and outcomes of unplanned return visits but few studies examine the reasons for return from a patient perspective. The objective of this integrative review was to determine the incidence, characteristics, outcomes and reasons for unplanned return visits to Emergency Departments. Read More

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http://dx.doi.org/10.1016/j.auec.2018.12.003DOI Listing

Are the ecological effects of the "worst" marine invasive species linked with scientific and media attention?

PLoS One 2019 18;14(4):e0215691. Epub 2019 Apr 18.

Red Sea Research Center (RSRC) and Computational Biosciences Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.

Non-native species are a major driver of environmental change. In this study we assessed the ecological impact of the "worst" non-native species and the associated scientific and media publications through time to understand what influences interest in these species. Ecological effect was based on a qualitative assessment reported in research publications and additional searches of the scientific and media attention were conducted to determine published articles and assess attention. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215691PLOS

Performance and workflow assessment of six nucleic acid extraction technologies for use in resource limited settings.

PLoS One 2019 18;14(4):e0215753. Epub 2019 Apr 18.

PATH, Seattle, Washington, United States of America.

Infectious disease nucleic acid amplification technologies (NAAT) have superior sensitivity, specificity, and rapid time to result compared to traditional microbiological methods. Recovery of concentrated, high quality pathogen nucleic acid (NA) from complex specimen matrices is required for optimal performance of several NA amplification/detection technologies such as polymerase chain reaction (PCR). Fully integrated NAAT platforms that enable rapid sample-to-result workflows with minimal user input are generally restricted to larger reference lab settings, and their complexity and cost are prohibitive to widespread implementation in resource limited settings (RLS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215753PLOS

How is your mind-set? Proof of concept for the measurement of the level of emotional development.

PLoS One 2019 18;14(4):e0215474. Epub 2019 Apr 18.

Freie Universität Berlin, Fakultät für Erziehungswissenschaft und Psychologie, AB Klinisch-Psychologische Intervention, Berlin, Germany.

Background: In persons with intellectual and developmental disabilities, not only cognitive brain functions, but also socio-emotional processing networks may be impaired. This study aims to validate the Scale of Emotional Development-Short (SED-S) to provide an instrument for the assessment of socio-emotional brain functions.

Method: The SED-S was applied in 160 children aged 0-12 years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215474PLOS

Fluorodeoxyglucose Positron Emission Tomography integrated with computed tomography in carcinoma of the cervix: Its impact on accurate staging and the predictive role of its metabolic parameters.

PLoS One 2019 18;14(4):e0215412. Epub 2019 Apr 18.

Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa.

Objectives: To determine the impact of FDG-PET/CT in the initial staging of cervical cancer among women with and without HIV and to determine the abilities of FDG-PET/CT metabolic parameters in predicting the presence of distant metastasis.

Methods: We reviewed the FDG-PET/CT images of women with FIGO stage IB2 to IVA carcinoma of the cervix. We compared the FIGO stage before and after FDG-PET/CT. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215412PLOS

Farmers' perceptions on the causes of cassava root bitterness: A case of konzo-affected Mtwara region, Tanzania.

PLoS One 2019 18;14(4):e0215527. Epub 2019 Apr 18.

Roots and Tubers Department, Naliendele Agricultural Research Institute, Mtwara, Tanzania.

In areas where konzo (a cassava cyanide related paralytic disorder) persists, the agronomic factors causing increased cyanogenic glucoside levels in cassava, during periods without water stress, are hardly known. However, through their assessment of cassava root toxicity, using its bitter taste, farmers may have noticed factors unrelated to water stress that additionally influence the cyanogenic glucoside content of cassava cultivated in these areas. Increased cassava root bitterness is often associated with an increase in cyanogenic glucoside levels, making it a good indicator of changes in root cyanogenic glucoside content. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215527PLOS

AIDS prevention and control in the Yunnan region by T cell subset assessment.

PLoS One 2019 18;14(4):e0214800. Epub 2019 Apr 18.

Yunnan Key Laboratory of Laboratory Medicine, Kunming, Yunan, China.

Background: Prior to being spread throughout broader China, multiple human immunodeficiency virus (HIV)-1 genotypes were originally discovered in the Yunnan Province. As the HIV-1 epidemic continues its spread in Yunnan, knowledge of the influence of gender, age, and ethnicity to instances of HIV reservoirs will benefit monitoring the spread of HIV.

Methods: The degree to which T cells are depleted during an HIV infection depends on the levels of immune activation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214800PLOS

Test-retest reliability of BSP, a battery of tests for assessing spatial cognition in visually impaired children.

PLoS One 2019 18;14(4):e0212006. Epub 2019 Apr 18.

Unit for Visually Impaired People, Center for Human Technologies, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.

Blind individuals are particularly dependent on their hearing for defining space. It has been found that both children and adults with visual impairments can struggle with complex spatial tasks that require a metric representation of space. Nonetheless the variability of methods employed to assess spatial abilities in absence of vision is wide, especially in the case of visually impaired children. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212006PLOS

A New Face Subunit Transplant Model in Mice, Containing Skin, Mandible, and Oral Mucosa for Future Face Vascularized Composite Allotransplantation Studies.

Plast Reconstr Surg 2019 Apr 11. Epub 2019 Apr 11.

Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: In immunologic research, mice have advantages over other animals, such as low costs, easy handling, suitable lifecycle, and adequate laboratory resources. However, mice vascularized composite allotransplantation (VCA) surgery is not popular, partly because of technical difficulties and high mortality rates. Our goal was to demonstrate a face transplantation model in mice that includes skin, mandible and oral mucosa. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005774DOI Listing

What Is the Association Between Articular Cartilage Damage and Subsequent THA 20 Years After Hip Arthroscopy for Labral Tears?

Clin Orthop Relat Res 2019 May;477(5):1211-1220

M. K. Dwyer, C. Tumpowsky, J. Lee, J. C. McCarthy, Kaplan Joint Center, Newton Wellesley Hospital, Newton, MA, USA M. K. Dwyer, J. C. McCarthy, Department of Orthopaedics, Massachusetts General Hospital, Boston, MA, USA A. Boone, Tufts University School of Medicine, Boston, MA, USA.

Background: Few studies have examined long-term outcomes for patients after arthroscopic treatment for intraarticular hip conditions, and none have done so beyond 10 years postarthroscopy. Examining outcomes beyond 10 years is necessary to determine factors that contribute to conversion to THA in patients undergoing hip arthroscopy for labrochondral damage.

Questions/purposes: (1) What is hip survivorship free from THA in patients who underwent arthroscopic labral débridement, with or without chondroplasty at least 15 years before? (2) What factors are associated with conversion to THA after arthroscopic labral débridement, with or without chondroplasty? (3) Can these data be used to estimate the risk of conversion to THA based on patient- and hip-related factors?

Methods: Between 1989 and 2000, one surgeon performed 552 arthroscopic hip procedures for symptomatic labral tears, with or without associated articular cartilage damage. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000717DOI Listing
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