935 results match your criteria Assay and drug development technologies[Journal]


Drug Delivery Research.

Authors:
Harsh Chauha

Assay Drug Dev Technol 2020 Jul 2. Epub 2020 Jul 2.

Special Editor of Drug Delivery Research, ASSAY and Drug Development Technologies.

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http://dx.doi.org/10.1089/adt.2020.29094.cfp3DOI Listing

ASSAY and Drug Development Technologies.

Authors:
Bruce Melancon

Assay Drug Dev Technol 2020 Jul 2. Epub 2020 Jul 2.

Vanderbilt Center for Neuroscience Drug Discovery, Franklin, TN, USA.

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http://dx.doi.org/10.1089/adt.2019.29090.cfp7DOI Listing

Validated Reverse Phase-High-Performance Liquid Chromatography Method for Estimation of Fisetin in Self-Nanoemulsifying Drug Delivery System.

Assay Drug Dev Technol 2020 Jun 29. Epub 2020 Jun 29.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

Fisetin (FS) is a polyphenolic phytoconstituent reported to have various pharmacological activities such as antioxidant, antiparkinsonian, and antidepressant. An analytical method was developed and validated for the estimation of FS by ultrafast liquid chromatography using C-18 reverse phase column. Acetonitrile and orthophosphoric acid (0. Read More

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http://dx.doi.org/10.1089/adt.2020.983DOI Listing

COVID-19 and the Drug Repurposing Tsunami.

Assay Drug Dev Technol 2020 Jun 18. Epub 2020 Jun 18.

H.M. Pharma Consultancy, Vienna, Austria.

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http://dx.doi.org/10.1089/adt.2020.996DOI Listing

Repurposing of an Antisepsis Drug in COVID-19 Patients.

Assay Drug Dev Technol 2020 Jun 3. Epub 2020 Jun 3.

Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.

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http://dx.doi.org/10.1089/adt.2020.994DOI Listing
June 2020
2.075 Impact Factor

Comparison Between Different 3D Spheroid Tumor Invasion Models.

Assay Drug Dev Technol 2020 May 28. Epub 2020 May 28.

Department of Pharmacology, University of Jordan, Amman, Jordan.

This study aims to make a comparison between different forms of three-dimensional (3D) spheroid U87 tumor cell models that contain fibroblast cells as part of the tumor microenvironment. This purpose is to select the best representative tumor model to be used for further studies to investigate the effects of the anti-invasive pharmacological agents. For this purpose, different options to prepare the 3D spherical invasion model were tested based on the ability of the spheroids to invade in collagen microenvironment. Read More

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http://dx.doi.org/10.1089/adt.2020.978DOI Listing

Combination of Resveratrol and Quercetin Causes Cell Growth Inhibition, DNA Damage, Cell Cycle Arrest, and Apoptosis in Oral Cancer Cells.

Assay Drug Dev Technol 2020 May 18. Epub 2020 May 18.

School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

Resveratrol and quercetin alone are well reported to have anticancer potential, but their combination studies are very inadequate. We have examined their combination in Cal-33 and SCC-15 oral cancer cells (OCCs) and noncancerous HEK-293 cells. Combination of 10 μM concentration of each resveratrol and quercetin brought additive effect on cellular growth, DNA damage, S-phase cell cycle arrest, and cell death in Cal-33 cells but not in the HEK-293 cells. Read More

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http://dx.doi.org/10.1089/adt.2020.972DOI Listing

A Fully Integrated Assay Panel for Early Drug Metabolism and Pharmacokinetics Profiling.

Assay Drug Dev Technol 2020 May/Jun;18(4):157-179. Epub 2020 May 14.

Mechanistic Biology & Profiling, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

Evaluation and optimization of physicochemical and metabolic properties of compounds are a crucial component of the drug development process. Continuous access to this information during the design-make-test-analysis cycle enables identification of chemical entities with suitable properties for efficient project progression. In this study, we describe an integrated and automated assay panel (DMPK Wave 1) that informs weekly on lipophilicity, solubility, human plasma protein binding, and metabolic stability in rat hepatocytes and human liver microsomes. Read More

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http://dx.doi.org/10.1089/adt.2020.970DOI Listing

Antifungal Activity of Capric Acid, Nystatin, and Fluconazole and Their Interactions Against Isolates from Neonatal Oral Thrush.

Assay Drug Dev Technol 2020 May/Jun;18(4):195-201. Epub 2020 May 11.

Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Science, Tehran, Iran.

Due to the increasing resistance of various species to azole drugs, particularly fluconazole, it would be of significant importance to look for alternative therapies. The aim of this study was to investigate the antifungal activity of capric acid and its interactions with nystatin and fluconazole against isolates. A total of 40 isolates (, 36; , 2; , 1; , 1) collected from the oral cavity of neonates with oropharyngeal candidiasis and a reference strain of (ATCC 10231) were used in this study. Read More

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http://dx.doi.org/10.1089/adt.2020.971DOI Listing

Fluorescence Resonance Energy Transfer-Based Assay Used to Determine the Rab27-Effector-Binding Affinity.

Assay Drug Dev Technol 2020 May/Jun;18(4):180-194. Epub 2020 May 7.

Division of Physiology, Pharmacology, and Neuroscience, Queen's Medical Centre, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.

The Rab27 subfamily consists of Rab27a/b isoforms that have similar but not identical functions. Those functions include the regulation of trafficking, docking, and fusion of various lysosome-related organelles and secretory granules; such as melanosomes in melanocytes and lytic granules in cytotoxic T lymphocytes. Rab27a/b exert their specific and versatile functions by interacting with 11 effector proteins, preferentially in their GTP-bound state. Read More

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http://dx.doi.org/10.1089/adt.2019.960DOI Listing

Development of a QPatch-Automated Electrophysiology Assay for Identifying TMEM16A Small-Molecule Inhibitors.

Assay Drug Dev Technol 2020 Apr;18(3):134-147

Department of Inflammation Discovery Research, Amgen, Inc., Thousand Oaks, California, USA.

The calcium-activated chloride channel, TMEM16A, is involved in airway hydration and bronchoconstriction and is a promising target for respiratory disease. Drug development efforts around channels require an electrophysiology-based assay for identifying inhibitors or activators. TMEM16A has proven to be a difficult channel to record on automated electrophysiology platforms due to its propensity for rundown. Read More

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http://dx.doi.org/10.1089/adt.2019.962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268545PMC

Preparation and Characterization of Griseofulvin Solid Dispersions.

Assay Drug Dev Technol 2020 Apr;18(3):109-118

School of Pharmacy and Health Professionals, Creighton University, Omaha, Nebraska, USA.

Amorphous solid dispersion (SD) technique has been used for improving the solubility and bioavailability of poorly water-soluble compounds. However, the stability of these SD is a concern due to the high propensity of metastable amorphous form to convert into its stable crystalline form. In this study, the stability of SD of griseofulvin (GSV), a high crystallization tendency compound, was evaluated in the presence of commonly used Food and Drug Administration-approved hydrophilic polymers such as polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose, Eudragits, and polyethylene glycol. Read More

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http://dx.doi.org/10.1089/adt.2019.965DOI Listing

ASSAY and Drug Development Technologies.

Authors:
Bruce Melancon

Assay Drug Dev Technol 2020 Apr;18(3):108

Vanderbilt Center for Neuroscience Drug Discovery, Franklin, TN, USA.

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http://dx.doi.org/10.1089/adt.2019.29090.cfp5DOI Listing

Drug Delivery Research.

Authors:
Harsh Chauha

Assay Drug Dev Technol 2020 May/Jun;18(4):155. Epub 2020 Apr 20.

Special Editor of Drug Delivery Research, ASSAY and Drug Development Technologies.

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http://dx.doi.org/10.1089/adt.2020.29094.cfp2DOI Listing

ASSAY and Drug Development Technologies.

Authors:
Bruce Melancon

Assay Drug Dev Technol 2020 May/Jun;18(4):156. Epub 2020 Apr 20.

Vanderbilt Center for Neuroscience Drug Discovery, Franklin, TN, USA.

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http://dx.doi.org/10.1089/adt.2019.29090.cfp6DOI Listing

Drug Delivery Research.

Authors:
Harsh Chauha

Assay Drug Dev Technol 2020 Apr 8;18(3):107. Epub 2020 Apr 8.

Special Editor of Drug Delivery Research, ASSAY and Drug Development Technologies.

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http://dx.doi.org/10.1089/adt.2020.29094.cfpDOI Listing

High-Performance Liquid Chromatography and Liquid Chromatography/Mass Spectrometry Studies on Stress Degradation Behavior of Sulfapyridine and Development of a Validated, Specific, Stability-Indicating HPLC Assay Method.

Assay Drug Dev Technol 2020 Apr 8;18(3):119-133. Epub 2020 Apr 8.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.

The objective of the current investigation was to develop a simple, rapid, and stability-indicating high-performance liquid chromatography method and to study the degradation behavior of sulfapyridine (SP) under different International Conference on Harmonization (ICH)-recommended conditions. The chromatographic method was developed using C (250 × 4.6 mm, 5 μ) column, and mobile phase consisting of acetonitrile-0. Read More

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http://dx.doi.org/10.1089/adt.2019.959DOI Listing

Drug Repurposing Patent Applications October-December 2019.

Assay Drug Dev Technol 2020 Mar 3. Epub 2020 Mar 3.

H.M. Pharma Consultancy, Vienna, Austria.

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http://dx.doi.org/10.1089/adt.2020.974DOI Listing

Introduction to the iPS Cells for Ischemic Stroke, Traumatic Brain Injury, and Other Brain-Related Diseases Special Issue.

Assay Drug Dev Technol 2020 Feb/Mar;18(2):77

Department of Pharmacology, University of Virginia, Charlottesville, Virginia.

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http://dx.doi.org/10.1089/adt.2020.29093.ersDOI Listing
February 2020

Drug Repurposing Patent Applications July-September 2019.

Assay Drug Dev Technol 2020 May/Jun;18(4):202-207. Epub 2020 Feb 6.

H.M. Pharma Consultancy, Wien, Austria.

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http://dx.doi.org/10.1089/adt.2019.969DOI Listing
February 2020

Drug Repurposing Patent Applications April-June 2019.

Assay Drug Dev Technol 2020 Apr 6;18(3):148-153. Epub 2020 Feb 6.

H.M. Pharma Consultancy, Vienna, Austria.

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http://dx.doi.org/10.1089/adt.2019.968DOI Listing

Phytochemical Repurposing of Natural Molecule: Sabinene for Identification of Novel Therapeutic Benefits Using and Approaches.

Assay Drug Dev Technol 2019 Nov/Dec;17(8):339-351

Department of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India.

Repurposing of drugs/natural or synthetic chemicals is a promising approach to identify the new therapeutic indication/use and mode of action. In pharmaceuticals, this process is used to save the time and cost for the drug discovery process with reduced risk of failure. In the present studies, repurposing of a natural molecule: sabinene (major phytochemical in cardamom) was used to characterize the new biological activities using in silico in vitro In silico similarity searching demonstrated that (+)-3-carene possessed the maximum structural similarity with sabinene. Read More

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http://dx.doi.org/10.1089/adt.2019.939DOI Listing
December 2019
2.075 Impact Factor

Systematically Prioritizing Candidates in Genome-Based Drug Repurposing.

Assay Drug Dev Technol 2019 Nov/Dec;17(8):352-363. Epub 2019 Nov 26.

Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee.

Drug repurposing is the application of approved drugs to treat diseases separate and distinct from their original indications. Herein, we define the scope of all practical precision drug repurposing using DrugBank, a publicly available database of pharmacological agents, and BioVU, a large, de-identified DNA repository linked to longitudinal electronic health records at Vanderbilt University Medical Center. We present a method of repurposing candidate prioritization through integration of pharmacodynamic and marketing variables from DrugBank with quality control thresholds for genomic data derived from the DNA samples within BioVU. Read More

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http://dx.doi.org/10.1089/adt.2019.950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921094PMC
November 2019

Re: "High-Content Screening Identifies New Inhibitors of Connexin 43 Gap Junctions" by Picoli ( 2019;17:240-248).

Assay Drug Dev Technol 2019 Nov/Dec;17(8):387. Epub 2019 Nov 22.

Executive Director, The Quinism Foundation, White River Junction, Vermont.

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http://dx.doi.org/10.1089/adt.2019.949DOI Listing
February 2020

Protective and Modulatory Effects of and on Neuroblastoma Cells Through Neuronal Nitric Oxide Synthase.

Assay Drug Dev Technol 2020 01 19;18(1):64-74. Epub 2019 Nov 19.

Department of Biotechnology, Graphic Era University, Dehradun, India.

The fruits of (TB) and seeds of (TF) are used for their nutraceutical properties in various systems of traditional medicine practiced in India. In this study aqueous and methanolic extracts of TB fruits and TF seeds were prepared and their protective effect was studied on hydrogen peroxide (HO)-treated neuroblastoma (NB-41) cell line. Cell viability, nitric oxide (NO) levels, mRNA, and protein profiles were analyzed and compared with untreated control. Read More

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http://dx.doi.org/10.1089/adt.2018.912DOI Listing
January 2020
2.075 Impact Factor

Zidovudine and Lamivudine as Potential Agents to Combat HIV-Associated Neurocognitive Disorder.

Assay Drug Dev Technol 2019 10;17(7):322-329

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.

C Read More

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http://dx.doi.org/10.1089/adt.2019.941DOI Listing
October 2019
2 Reads
2.075 Impact Factor

Drug Repurposing Approach for Developing Novel Therapy Against Mupirocin-Resistant .

Assay Drug Dev Technol 2019 10;17(7):298-309

Department of Biological Management, Goa Institute of Management, Sanquelim, India.

Staphylococcus aureus S. aureus S. aureus S. Read More

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http://dx.doi.org/10.1089/adt.2019.944DOI Listing
October 2019

Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda.

Assay Drug Dev Technol 2019 10;17(7):310-321

Department of Quantitative Biology, Eli Lilly and Company, Indianapolis, Indiana.

in vivo Read More

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http://dx.doi.org/10.1089/adt.2019.942DOI Listing
October 2019
2 Reads

Single-Molecule Characterization of Drug Delivery Systems.

Authors:
Sezer Okay

Assay Drug Dev Technol 2020 01 1;18(1):56-63. Epub 2019 Oct 1.

Department of Vaccine Technology, Vaccine Institute, Hacettepe University, Ankara, Turkey.

Delivery of the drug to a desired point of body and controlled release of the therapeutic agent are important features, provided by drug delivery systems (DDSs), for development of today's effective medicines. A variety of nanomaterials or nanomolecules such as lipids/liposomes, nucleic acids, peptides/proteins, composites, polymers, or carbon nanotubes can be used as DDSs. Single-molecule characterization of these small materials in terms of their size, shape, surface, encapsulation efficiency, as well as interaction with the drug-receiving cell has importance for their efficiency. Read More

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http://dx.doi.org/10.1089/adt.2018.903DOI Listing
January 2020

Molecular Docking and Cogitation Validate Mefenamic Acid Prodrugs as Human Cyclooxygenase-2 Inhibitor.

Assay Drug Dev Technol 2019 08;17(6):285-291

Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura, India.

In silico in silico in vivo in silico Read More

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http://dx.doi.org/10.1089/adt.2019.943DOI Listing

A Nonradioactive High-Throughput Screening-Compatible Cell-Based Assay to Identify Inhibitors of the Monocarboxylate Transporter Protein 1.

Assay Drug Dev Technol 2019 08;17(6):275-284

Department of Cancer Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1089/adt.2019.936DOI Listing
August 2019
2.075 Impact Factor

Fenugreek Leaf Extract and Its Gel Formulation Show Activity Against .

Assay Drug Dev Technol 2020 01 16;18(1):45-55. Epub 2019 Sep 16.

Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii.

spp. are commensal yeasts that can cause cutaneous ailments such as dandruff and seborrheic dermatitis. We sought to develop a cost-effective, herbal formulation for the treatment of cutaneous ailments related to spp. Read More

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http://dx.doi.org/10.1089/adt.2019.918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998042PMC
January 2020

Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor.

Assay Drug Dev Technol 2019 Nov/Dec;17(8):364-386. Epub 2019 Sep 6.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.

Prostate cancer is the leading cause of cancer and second leading cause of cancer-related death in men in the United States. Twenty percent of patients receiving the standard of care androgen deprivation therapy (ADT) eventually progress to metastatic and incurable castration-resistant prostate cancer (CRPC). Current FDA-approved drugs for CRPC target androgen receptor (AR) binding or androgen production, but only provide a 2- to 5-month survival benefit due to the emergence of resistance. Read More

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http://dx.doi.org/10.1089/adt.2019.940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921095PMC
September 2019
1 Read

Development of Nanoemulsion Preconcentrate of Capsanthin with Improved Chemical Stability.

Assay Drug Dev Technol 2020 01 6;18(1):34-44. Epub 2019 Sep 6.

Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii.

Capsanthin, like other carotenoids, exhibits poor aqueous solubility, poor stability, and low/variable oral bioavailability that limit its utility as a nutraceutical. In this study, we describe the development of anhydrous nanoemulsion preconcentrate of capsanthin, which upon dilution with water, spontaneously forms nanoemulsion resulting in improved solubility of capsanthin without compromising its chemical stability and antioxidant activity. We chose Food and Drug Administration-approved ingredients to develop capsanthin nanoemulsion preconcentrates. Read More

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http://dx.doi.org/10.1089/adt.2019.916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998047PMC
January 2020

Developing a High-Throughput Assay for the Integral Membrane Glycerol 3-Phosphate Acyltransferase.

Assay Drug Dev Technol 2019 08 12;17(6):267-274. Epub 2019 Aug 12.

Center for Excellence in Molecular Cell Science, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

- V of 57.5 μmol min mg, K Read More

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http://dx.doi.org/10.1089/adt.2019.935DOI Listing

High-Content Screening Identifies New Inhibitors of Connexin 43 Gap Junctions.

Assay Drug Dev Technol 2019 07;17(5):240-248

1Theranexus, Lyon, France.

Gap junctions (GJs) are dynamic structures composed of hexamers of connexins (Cxs), a class of transmembrane proteins enabling channel-mediated direct intercellular communication through cell-cell diffusion of ions and small metabolites. In defined conditions, Cxs also work as hemichannels allowing exchanges between the cytoplasm and the extracellular medium. The most common GJ channel is formed by connexin 43 (Cx43) and plays an important role in physiological and pathological processes in excitable tissues, such as heart and brain. Read More

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http://dx.doi.org/10.1089/adt.2019.927DOI Listing

Drug Repurposing Patent Applications October-December 2018.

Assay Drug Dev Technol 2019 07 3;17(5):249-254. Epub 2019 Jul 3.

1H. M. Pharma Consultancy, Wien, Austria.

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http://dx.doi.org/10.1089/adt.2019.937DOI Listing

Drug Repurposing Patent Applications January-March 2019.

Assay Drug Dev Technol 2019 Jul 3;17(5):255-260. Epub 2019 Jul 3.

H. M. Pharma Consultancy, Wien, Austria.

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http://dx.doi.org/10.1089/adt.2019.938DOI Listing
July 2019
1 Read

Axitinib-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles for Age-Related Macular Degeneration: Formulation Development and Characterization.

Assay Drug Dev Technol 2019 May/Jun;17(4):167-177

Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida.

in vitro in vitro ± ± ± in vitro Read More

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https://www.liebertpub.com/doi/10.1089/adt.2019.920
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http://dx.doi.org/10.1089/adt.2019.920DOI Listing
May 2020
14 Reads
2.075 Impact Factor

Special Issue: Drug Delivery Systems and Technologies Part I.

Authors:
Harsh Chauhan

Assay Drug Dev Technol 2019 May/Jun;17(4):151

School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska.

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http://dx.doi.org/10.1089/adt.2019.29088.hchDOI Listing
May 2020
1 Read

Evaluation of Small Molecule Delivery into Articular Cartilage: Effect of Synovial Clearance and Compressive Load.

Assay Drug Dev Technol 2019 May/Jun;17(4):191-200

1 Department of Developmental BioEngineering, MIRA Institute, University of Twente, Enschede, The Netherlands.

in vitro . Read More

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http://dx.doi.org/10.1089/adt.2018.907DOI Listing
May 2020
10 Reads

Analysis and Quantification of Oxidized Low-Density Lipoprotein-Induced Lipid Droplets in Macrophages Through High-Content Screening: Application for Antiatherogenic Drugs Discovery.

Assay Drug Dev Technol 2019 07 31;17(5):223-230. Epub 2019 May 31.

2Department of Ophthalmology, National Taiwan University Hospital, Taipei, Republic of China.

In vascular systems, macrophages can engulf circulating oxidized (ox) low-density lipoprotein (LDL), leading to the accumulation of intracellular lipid droplets, which forms foam cells. Macrophage-derived foam cells are an important therapeutic target for atherosclerosis. However, quantifying intracellular lipid droplets in macrophages is difficult. Read More

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http://dx.doi.org/10.1089/adt.2019.930DOI Listing
July 2019
1 Read

Automated Machine Learning Diagnostic Support System as a Computational Biomarker for Detecting Drug-Induced Liver Injury Patterns in Whole Slide Liver Pathology Images.

Authors:
Munish Puri

Assay Drug Dev Technol 2020 01 31;18(1):1-10. Epub 2019 May 31.

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, Maryland.

in vivor p R. Read More

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http://dx.doi.org/10.1089/adt.2019.919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998050PMC
January 2020
3 Reads

The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons.

Assay Drug Dev Technol 2020 Feb/Mar;18(2):97-103. Epub 2019 May 16.

Department of Pharmacology, University of Virginia, Charlottesville, Virginia.

Neurological diseases comprise more than a thousand ailments that adversely affect the brain and nervous system. When grouped together, these neurological conditions impact an estimated 100 million individuals in the United States and up to a billion people worldwide, making drug discovery efforts imperative. However, recent research and development efforts for these neurological diseases, including Alzheimer's disease and amyotrophic lateral sclerosis, have been exceedingly disappointing and typify the challenges associated with translating and cell-based discoveries to successful preclinical models and subsequent human clinical trials. Read More

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http://dx.doi.org/10.1089/adt.2019.914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047103PMC
May 2019
5 Reads

Human-Derived Brain Models: Windows into Neuropsychiatric Disorders and Drug Therapies.

Assay Drug Dev Technol 2020 Feb/Mar;18(2):79-88. Epub 2019 May 15.

Department of Anatomy and Cell Biology, East Carolina University Brody School of Medicine, Greenville, North Carolina.

Human-derived neurons and brain organoids have revolutionized our ability to model brain development in a dish. In this review, we discuss the potential for human brain models to advance drug discovery for complex neuropsychiatric disorders. First, we address the advantages of human brain models to screen for new drugs capable of altering CNS activity. Read More

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http://dx.doi.org/10.1089/adt.2019.922DOI Listing
May 2019
3 Reads

Micro/Nanoparticle Delivery Systems for Ocular Diseases.

Assay Drug Dev Technol 2019 May/Jun;17(4):152-166. Epub 2019 May 15.

1 Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida.

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http://dx.doi.org/10.1089/adt.2018.911DOI Listing
May 2020
1 Read

Neural Progenitor Cell Derivation Methodologies for Drug Discovery Applications.

Assay Drug Dev Technol 2020 Feb/Mar;18(2):89-95. Epub 2019 May 15.

Stem Cell Core Facility, University of Virginia, Charlottesville, Virginia.

Inducible pluripotent stem cells (iPSCs) are being used to model brain disorders across the continuum of neurodevelopment, neurodegenerative, and neuropsychiatric disease allowing for the mechanistic unraveling of the neurological disease state. Subsequently, there is a diverse array of cell model systems that can be used for target validation, pharmacodynamic endpoint development, and high-throughput/content assay development and screening. However, to successfully model neurological disorders with iPSCs, the disease-relevant neuron must be first identified, and it is critical to have the appropriate neuronal progenitor cell derivation and neuron differentiation protocols available to produce desired neuronal phenotypes. Read More

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http://dx.doi.org/10.1089/adt.2019.921DOI Listing
May 2019
2 Reads

The Role of Polyethylene Glycol Size in Chemical Spectra, Cytotoxicity, and Release of PEGylated Nanoliposomal Cisplatin.

Assay Drug Dev Technol 2019 07 13;17(5):231-239. Epub 2019 May 13.

5Center for Infrastructure Engineering, Western Sydney University, Australia.

This study aimed to synthesize methoxy polyethylene glycol propionaldehyde (mPEG-ALD) for the preparation of PEGylated nanoliposomal cisplatin. Nanocarriers such as liposomes are developed for a wide range of drug delivery systems. PEG with high molecular weight (Mw) is used to coat the liposomes. Read More

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http://dx.doi.org/10.1089/adt.2019.923DOI Listing
July 2019
2 Reads