1,014 results match your criteria Assay And Drug Development Technologies[Journal]


Developmental Cardiotoxicity and Hepatotoxicity of Flurbiprofen Axetil to Zebrafish Embryo.

Assay Drug Dev Technol 2022 Apr;20(3):125-135

Department of Anesthesiology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.

Flurbiprofen axetil (FA) is a nonsteroidal targeted analgesic and widely used for postoperative analgesia and cancer analgesia. Extensive works have been done in the evaluation of FA's clinical analgesic effect on adults. Along with the increase of FA usage, the potential toxicity and molecular mechanism in embryo development need to be better understood. Read More

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Special Issue on High-throughput Technologies for the Discovery and Development of Chemical Probes and Pharmacological Tools.

Assay Drug Dev Technol 2022 Feb 3. Epub 2022 Feb 3.

Vanderbilt University School of Medicine, Franklin, TN, USA.

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February 2022

Chemical Probes and Pharmacological Tools for Kinase Signaling.

Assay Drug Dev Technol 2022 Feb 3. Epub 2022 Feb 3.

Vanderbilt University School of Medicine, Franklin, TN, USA.

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February 2022

New Modalities in Chemical Probes and Pharmacological Tools in Drug Discovery.

Assay Drug Dev Technol 2022 Apr 1;20(3):103-104. Epub 2022 Apr 1.

Vanderbilt University School of Medicine, Franklin, TN, USA.

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Chemical Probes and Pharmacological Tools for Imaging Applications.

Assay Drug Dev Technol 2022 Apr 1;20(3):105-106. Epub 2022 Apr 1.

Vanderbilt University School of Medicine, Franklin, TN, USA.

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Interview with Craig W. Lindsley, PhD.

Authors:
Bruce J Melancon

Assay Drug Dev Technol 2022 Apr 31;20(3):109-110. Epub 2022 Mar 31.

Editor-in-Chief.

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Forging Ahead with .

Authors:
Bruce J Melancon

Assay Drug Dev Technol 2022 Apr 30;20(3):107-108. Epub 2022 Mar 30.

ASSAY and Drug Development Technologies.

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Development of a High-Throughput Screening Assay for Small-Molecule Inhibitors of Androgen Receptor Splice Variants.

Assay Drug Dev Technol 2022 Apr 23;20(3):111-124. Epub 2022 Mar 23.

Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.

The role of the androgen receptor (AR) in the progression of prostate cancer (PCa) is well established and competitive inhibition of AR ligand binding domain (LBD) has been the mainstay of antiandrogen therapies for advanced and metastatic disease. However, the efficacy of such drugs is often limited by the emergence of resistance, mediated through point mutations and receptor splice variants lacking the AR-LBD. As a result, the prognosis for patients with malignant, castrate-resistant disease remains poor. Read More

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Modifications to the Transwell Migration/Invasion Assay Method That Eases Assay Performance and Improves the Accuracy.

Assay Drug Dev Technol 2022 Feb-Mar;20(2):75-82. Epub 2022 Feb 23.

Cell Reprogramming & Therapeutics LLC, Wauwatosa, Wisconsin, USA.

Migration is a key property of live cells and critical for normal development, immune response, and disease processes such as cancer metastasis and inflammation. Methods to examine cell migration are especially useful and important for a wide range of biomedical research such as cancer biology, immunology, vascular biology, cell biology, and developmental biology. assays are excellent approaches to extrapolate to situations and study live cells behavior. Read More

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A New Spectral Shift-Based Method to Characterize Molecular Interactions.

Assay Drug Dev Technol 2022 Feb-Mar;20(2):83-94. Epub 2022 Feb 15.

NanoTemper Technologies GmbH, Munich, Germany.

There are many fluorescence-based applications that can be used to characterize molecular interactions. However, available methods often depend on site-specific labeling techniques or binding-induced changes in conformation or size of the probed target molecule. To overcome these limitations, we applied a ratiometric dual-emission approach that quantifies ligand-induced spectral shifts with sub-nanometer sensitivity. Read More

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Repurposing of Hydroxyurea Against COVID-19: A Promising Immunomodulatory Role.

Assay Drug Dev Technol 2022 01 6;20(1):55-62. Epub 2022 Jan 6.

Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.

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January 2022

Formulation of Lipid-Based Nanocarriers of Lacidipine for Improvement of Oral Delivery: Box-Behnken Design Optimization, , , and Preclinical Assessment.

Assay Drug Dev Technol 2022 01 31;20(1):5-21. Epub 2021 Dec 31.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

The present research work was aimed to develop and optimize the nanostructured lipid carrier (NLCs) of the antihypertensive drug lacidipine (LAC) for the improvement of oral bioavailability and antihypertensive activity. LAC-NLCs were successfully developed by the preemulsion probe sonication technique. The formulations were optimized by Box-Behnken design and assessed for particle size (PS), polydispersity index (PDI), entrapment efficiency (EE), drug loading (DL), drug release, permeation, and study. Read More

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January 2022

Automated Assays to Identify Modulators of Transcription Factor EB Translocation and Autophagy.

Assay Drug Dev Technol 2022 Feb-Mar;20(2):67-74. Epub 2021 Dec 13.

Theranexus, R&D Department, Lyon, France.

Autophagy is a process leading to the degradation of cellular material, in organelles called lysosomes, to supply energy or generate building blocks for the synthesis of new materials. Over the past decades, its role has been evidenced in several indications, notably in neurodegenerative disorders and orphan diseases called lysosomal storage disorders and its modulation is largely envisioned as a therapeutic avenue to alleviate the symptoms and reverse the clinical courses of these indications. Identifying new chemical classes and drugs is, hence, of huge importance. Read More

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Development of Topical Nanoemulgel Using Combined Therapy for Treating Psoriasis.

Assay Drug Dev Technol 2022 01 9;20(1):42-54. Epub 2021 Dec 9.

I.T.S College of Pharmacy, Murad Nagar, Ghaziabad, India.

This study focuses on the development of topical formulation of methoxsalen using Babchi oil as formulation component that can be applied at body surfaces providing sustained delivery and enhanced penetration of methoxsalen leading to significant epidermal localization and better anti-psoriatic activity. The combination of psoralens, that is, methoxsalen (synthetic) and Babchi oil (natural) has been developed into nanoemulgel formulations. A total of four nanoemulsion formulations was developed using Babchi oil as oil phase and Tween 80 as surfactant by high-pressure homogenization method. Read More

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January 2022

Self-Assembled Nanomicelles to Enhance Solubility and Anticancer Activity of Etoposide.

Assay Drug Dev Technol 2021 Nov-Dec;19(8):526-538. Epub 2021 Nov 22.

Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri, USA.

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Development and Evaluation of Pectin Based Enteric Coated Microparticles Loaded with Mesalamine and for Management of Ulcerative Colitis.

Assay Drug Dev Technol 2022 01 15;20(1):22-34. Epub 2021 Nov 15.

Department of Pharmaceutics, ISF College of Pharmacy, Moga, India.

Mesalamine is the first-line choice of drug for ulcerative colitis management. However, due to the nontargeted delivery of mesalamine, it shows side effects. The possible impact of mesalamine can be improved by coated microparticles in combination with for targeted delivery to the colon with the prevention of unwanted side effects. Read More

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January 2022

Activities of Nanoparticles Against Fluconazole-Resistant in Clinical Isolates.

Assay Drug Dev Technol 2021 Nov-Dec;19(8):501-507. Epub 2021 Nov 12.

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

p Read More

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Determination of Microstructural Impact on the Release of Drug from Hydroxypropyl Cellulose Gel by Validated Release Test Method.

Assay Drug Dev Technol 2021 Nov-Dec;19(8):484-500. Epub 2021 Nov 10.

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, India.

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Enhancing Etoposide Aqueous Solubility and Anticancer Activity with L-Arginine.

Assay Drug Dev Technol 2021 Nov-Dec;19(8):508-525. Epub 2021 Nov 10.

Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas city, Kansas City, Missouri, USA.

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Development and Validation of High-Performance Liquid Chromatography Method for the Quantification of Remdesivir in Intravenous Dosage Form.

Assay Drug Dev Technol 2021 Nov-Dec;19(8):475-483. Epub 2021 Oct 18.

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.

± Read More

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December 2021

A Genome-Edited ERα-HiBiT Fusion Reporter Cell Line for the Identification of ERα Modulators High-Throughput Screening and CETSA.

Assay Drug Dev Technol 2021 Nov-Dec;19(8):539-549. Epub 2021 Oct 14.

National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.

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Nano Spray-Dried Drugs for Oral Administration: A Review.

Assay Drug Dev Technol 2021 10 21;19(7):412-441. Epub 2021 Sep 21.

Institute for Energy Systems, Eastern Switzerland University of Applied Sciences of Technology, Buchs, Switzerland.

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October 2021

Re: " Repurposing of an Antisepsis Drug in COVID-19 Patients," by Kumar

Authors:
Rajni Rani

Assay Drug Dev Technol 2021 10 31;19(7):408-409. Epub 2021 Aug 31.

Molecular Immunogenetics Group, National Institute of Immunology, New Delhi, India.

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October 2021

Antifungal Effects of Voriconazole-Loaded Nano-Liposome on FluconazoleResistant Clinical Isolates of , Biological Activity and and Gene Expression.

Assay Drug Dev Technol 2021 10 25;19(7):453-462. Epub 2021 Aug 25.

Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

ERG11 CDR1 CDR2 Candida albicans C. albicans was ERG11 CDR1, CDR2 C. albicans ERG11 C. Read More

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October 2021

Utilization of an Intracellular Calcium Mobilization Assay for the Screening of Transduced FK506-Binding Proteins.

Assay Drug Dev Technol 2021 10 19;19(7):442-452. Epub 2021 Aug 19.

Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Korea.

Z Read More

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October 2021

Repurposing Psychotropic Agents for Viral Disorders: Beyond Covid.

Assay Drug Dev Technol 2021 Aug-Sep;19(6):373-385. Epub 2021 Aug 10.

Department of Pediatric Hematology Oncology, the University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Recent reports have highlighted the possible role of the antipsychotic chlorpromazine and the antidepressant fluvoxamine as anti-coronavirus disease 2019 (COVID-19) agents. The objective of this narrative review is to explore what is known about the activity of psychotropic medications against viruses in addition to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). PubMed was queried for "drug repurposing, antiviral activity," and for "antiviral activity" with "psychotropic drugs" and individual agents, through November 2020. Read More

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September 2021

Pharmaceutical Perspective in Wearable Drug Delivery Systems.

Assay Drug Dev Technol 2021 Aug-Sep;19(6):386-401. Epub 2021 Aug 2.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India.

Humans have been dealing with health problems for millions of years. Normal health services need well-trained personnel and high-cost diagnostic tests, which forces patients to go to hospitals if medical treatment is required. To address this, prototype testing has been carried out into the wearable drug delivery health care perspectives. Read More

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January 2022