1,133 results match your criteria Aspergillosis Thoracic


Unilateral upper lung-field pulmonary fibrosis radiologically consistent with pleuroparenchymal fibroelastosis after thoracic surgery: Clinical and radiological courses with autopsy findings.

Respir Investig 2020 Jul 10. Epub 2020 Jul 10.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.

Background: Pleuroparenchymal fibroelastosis (PPFE) is a rare idiopathic interstitial pneumonia characterized by pleural and parenchymal involvements predominantly in the upper lobes. Unilateral upper-lung field pulmonary fibrosis (upper-PF) radiologically consistent with PPFE was recently reported in patients with a history of open thoracotomy and presented with impaired thoracic movements in the operated side with unknown mechanisms. This retrospective study aimed to elucidate the clinical and radiological courses and pathological findings of unilateral upper-PF. Read More

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http://dx.doi.org/10.1016/j.resinv.2020.05.001DOI Listing

High detection rate of azole-resistant Aspergillus fumigatus after treatment with azole antifungal drugs among patients with chronic pulmonary aspergillosis in a single hospital setting with low azole resistance.

Med Mycol 2020 Jul 9. Epub 2020 Jul 9.

Division of Clinical Research, Medical Mycology Research Centre, Chiba University, Chiba, Japan.

The prevalence of azole-resistant Aspergillus fumigatus (ARAF) among chronic pulmonary aspergillosis (CPA) patients treated with azoles in Japan is unknown. The aim of this study was to determine the detection rate of ARAF in isolates from CPA patients who were treated with azoles for varying durations. The potential mechanism of acquiring resistance was examined by sequencing cyp51A and hmg1, two genes associated with ARAF. Read More

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http://dx.doi.org/10.1093/mmy/myaa052DOI Listing

Solitary fibrous tumor of the pleura with marked cystic degeneration: a case report.

Surg Case Rep 2020 Jul 7;6(1):163. Epub 2020 Jul 7.

Division of Thoracic Surgery, Respiratory Disease Center, Seirei Mikatahara General Hospital, 3453, Mikatahara-cho, Kita-ku Hamamatsu, Shizuoka, Japan.

Background: Solitary fibrous tumor of the pleura (SFTP) is a mesenchymal tumor, and computed tomography typically shows SFTPs as well-defined lobulated masses. We herein report a case of SFTP with cystic degeneration of the entire tumor.

Case Presentation: The patient was a 67-year-old Japanese man who was referred to our hospital for an abnormal shadow on a chest X-ray. Read More

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http://dx.doi.org/10.1186/s40792-020-00931-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340714PMC

Invasive Pulmonary Aspergillosis in Chronic Obstructive Pulmonary Disease Exacerbations.

Semin Respir Crit Care Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Nowadays, reports in the literature support that patients with severe chronic obstructive pulmonary disease (COPD) are at higher risk to develop invasive pulmonary aspergillosis (IPA). However, the interpretation of -positive cultures from the airways in critically ill COPD is still a challenge. Indeed, as the patient could be merely colonized, tissue samples are required to ascertain IPA diagnosis but they are rarely obtained before death. Read More

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http://dx.doi.org/10.1055/s-0040-1702210DOI Listing

Intrathoracic Muscle Flap Transposition for the Management of Chronic Pulmonary Aspergillosis.

J Plast Reconstr Aesthet Surg 2020 May 26. Epub 2020 May 26.

Division of Plastic Surgery, Department of Surgery, Mayo Clinic, 200 First Street SW Rochester, MN. Electronic address:

Background: The management of chronic pulmonary aspergillosis remains a challenge for thoracic and reconstructive surgeons. Different management options have been proposed with no consensus regarding the best treatment modality. The goal of this study is to report our experience with the use of intrathoracic muscle flaps for the management of pulmonary aspergillosis. Read More

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http://dx.doi.org/10.1016/j.bjps.2020.05.068DOI Listing

Low Rate of Invasive Fungal Infections During Induction and Consolidation Chemotherapy for Adults with De Novo Acute Myeloid Leukemia Without Anti-mold Prophylaxis: Single-Center 2002-2018 Empirical/Pre-emptive Approach.

Mycopathologia 2020 Jun 20. Epub 2020 Jun 20.

Division of Clinical Hematology, Department of Radiology, Hospital de la Sant Creu i Sant Pau, Universitat Autónoma de Barcelona, Av. Mas Casanovas, 90, 08041, Barcelona, Spain.

Broad-spectrum antifungal prophylaxis is currently considered the standard of care for adults with de novo AML for the prevention of invasive fungal infections (IFIs), especially invasive pulmonary aspergillosis (IPA). Because fluconazole has been used in our center as anti-yeast prophylaxis, we sought to analyze in detail the incidence of IFIs over a 17-year period, as well as their impact on outcome. A standardized protocol of patient management, including serum galactomannan screening and thoracic CT-guided diagnostic-driven antifungal therapy, was used in all patients. Read More

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http://dx.doi.org/10.1007/s11046-020-00461-wDOI Listing

Secondary pulmonary alveolar proteinosis treated by lung transplant: A case report.

Respir Med Case Rep 2020 30;30:101108. Epub 2020 May 30.

Division of Pulmonology, Geneva University Hospitals, 1211, Geneva, Switzerland.

Background: Pulmonary alveolar proteinosis (PAP) is a pulmonary disease characterized by disruption of surfactant homeostasis resulting in its accumulation in the alveoli. PAP is classically classified into three categories (Table 1): 1/primary (or autoimmune) with antibodies targeting the GM-CSF pathway, 2/secondary to another disease, typically a hematologic malignancy, and 3/genetic.

Case-report: A 30 year-old woman received an allogenic hematopoietic stem cell transplantation (HSCT) after treatment for acute myeloid leukemia (AML). Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276430PMC

Surgical Management of an Empyema in a 3-Year-Old Child.

Case Rep Med 2020 5;2020:5179292. Epub 2020 May 5.

Department of Thoracic Surgery, Sismanoglio General Hospital of Athens, Athens, Greece.

empyema in nonimmunocompromised children is rare. A case of surgical management of invasive aspergillosis in a previously healthy 3-year-old child is presented. The patient was initially admitted to a hospital with severe respiratory deterioration and clinical instability, originally attributed to sepsis. Read More

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http://dx.doi.org/10.1155/2020/5179292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225848PMC

Madelung's disease and pulmonary aspergillosis: a case report and literature review.

J Cardiothorac Surg 2020 May 25;15(1):114. Epub 2020 May 25.

Department of Thoracic Surgery, Second Affiliated Hospital of Kunming Medical University, 374th Dianmian Road, Kunming, 650101, China.

Background: Madelung's disease (MD) is a rare disorder of fat metabolism, which is usually associated with diabetes, hyperuricemia, liver disease, nevertheless there is no report of a patient with MD and pulmonary aspergillosis (PA). This article aimed to enhance the awareness of this two diseases and discuss the possible mechanism of the combination of them preliminarily.

Case Presentation: In this case, we described a 56-year-old male patient with cough, expectoration and dyspnea. Read More

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http://dx.doi.org/10.1186/s13019-020-01166-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249672PMC

COVID-19 associated pulmonary aspergillosis.

Mycoses 2020 Jun 15;63(6):528-534. Epub 2020 May 15.

Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.

Objectives: Patients with acute respiratory distress syndrome (ARDS) due to viral infection are at risk for secondary complications like invasive aspergillosis. Our study evaluates coronavirus disease 19 (COVID-19) associated invasive aspergillosis at a single centre in Cologne, Germany.

Methods: A retrospective chart review of all patients with COVID-19 associated ARDS admitted to the medical or surgical intensive care unit at the University Hospital of Cologne, Cologne, Germany. Read More

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http://dx.doi.org/10.1111/myc.13096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267243PMC

Potential value of serum Aspergillus IgG antibody detection in the diagnosis of invasive and chronic pulmonary aspergillosis in non-agranulocytic patients.

BMC Pulm Med 2020 Apr 15;20(1):89. Epub 2020 Apr 15.

Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.

Background: At present, serum Aspergillus IgG and IgM antibody detection is mainly used in the diagnosis of chronic pulmonary aspergillosis (CPA), but its value in the diagnosis of invasive pulmonary aspergillosis (IPA) in non-agranulocytic patients is still unclear. IgM can be used as a marker of acute infection to help diagnose acute infection-related diseases. IgG is a marker of long-term infection and is used to assist in the diagnosis of pre-existing or chronic infection-related diseases. Read More

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http://dx.doi.org/10.1186/s12890-020-1125-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158007PMC

Interferon gamma replacement as salvage therapy in chronic pulmonary aspergillosis: effects on frequency of acute exacerbation and all-cause hospital admission.

Thorax 2020 Jun 30;75(6):513-516. Epub 2020 Mar 30.

National Aspergillosis Centre, Manchester University NHS Foundation Trust, Manchester, UK

Chronic pulmonary aspergillosis (CPA) is often poorly responsive to antifungal treatment; secondary infections increase morbidity/mortality, particularly in progressive cases. Interferon gamma (IFNγ) has been implicated in not only control but also bacterial clearance. Clinical notes of patients with CPA treated with IFNγ (2011-2018) were retrospectively hand-searched. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2019-213606DOI Listing

Pathogenicity and Immune Responses of Infection in Chickens.

Front Vet Sci 2020 11;7:143. Epub 2020 Mar 11.

College of Animal Science and Technology, Shandong Agricultural University, Taian, China.

is a ubiquitous pathogen in poultry farms, causing aspergillosis in chickens. To study the pathogenicity of , 14-days-old chickens were infected with fungal conidia (2 × 10 CFU/mL) via thoracic intra-air sacs inoculation. The clinical symptoms, gross and histopathological lesions, and fungal load in the lungs were examined. Read More

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http://dx.doi.org/10.3389/fvets.2020.00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078108PMC

A Rare Presentation of Pulmonary Aspergillosis: Bronchial Stump Aspergillosis.

J Bronchology Interv Pulmonol 2020 Apr;27(2):e28-e33

Chest Diseases, Hacettepe University Faculty of Medicine Ankara.

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http://dx.doi.org/10.1097/LBR.0000000000000655DOI Listing

Case 9-2020: A 64-Year-Old Man with Shortness of Breath, Cough, and Hypoxemia.

N Engl J Med 2020 Mar;382(12):1150-1159

From the Departments of Medicine (K.L.R., R.J.S., M.K.M.), Radiology (F.J.F.), and Pathology (J.E.), Massachusetts General Hospital, and the Departments of Medicine (K.L.R., R.J.S., M.K.M.), Radiology (F.J.F.), and Pathology (J.E.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1909621DOI Listing

Pulmonary infection due to Acrophialophora fusispora in a patient with underlying mixed connective tissue disease and chronic pulmonary aspergillosis: A case report and review of literature.

J Mycol Med 2020 Jun 22;30(2):100932. Epub 2020 Jan 22.

Department of Microbiology, All India Institute of Medical Sciences, Phase 2 Industrial Area, 342005 Jodhpur, Rajasthan, India.

Acrophialophora fusispora is a soil-borne fungus rarely implicated in human infections. Here, we report a case of pulmonary infection due to A. fusispora in a 59-year-old male who presented with productive cough and gradually progressive dyspnoea for 20 days. Read More

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http://dx.doi.org/10.1016/j.mycmed.2020.100932DOI Listing

An atypical acute exacerbation of COPD due to Aspergillus fumigatus.

Monaldi Arch Chest Dis 2020 Jan 27;90(1). Epub 2020 Jan 27.

Department of Pulmonary Medicine, Cerrahpasa Medical Faculty, Istanbul Cerrahpasa University.

A 64-year-old male with a history of stabile chronic obstructive pulmonary disease (COPD) presented with increasing dyspnea and sputum for the last two months. Complete blood count showed WBC 14x103/ml, Hgb: 14.2 g/dL and eosinophilia. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1155DOI Listing
January 2020

Pulmonary aspergillosis as a late complication after surgery for locally advanced non-small cell lung cancer treated with induction chemoradiotherapy.

Surg Today 2020 Jan 21. Epub 2020 Jan 21.

Department of General Thoracic Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Purpose: Some long-term survivors after surgery for locally advanced non-small cell lung cancer (NSCLC) treated with induction chemoradiotherapy (trimodality treatment) develop chronic pulmonary aspergillosis (CPA). The aim of our study was to assess the characteristics and outcomes of CPA that develops after trimodality treatment.

Methods: We retrospectively reviewed the data of 187 NSCLC patients who underwent trimodality treatment between 1999 and 2018. Read More

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http://dx.doi.org/10.1007/s00595-020-01960-5DOI Listing
January 2020

Levels of evidence supporting clinical practice guidelines on invasive aspergillosis.

Eur J Clin Microbiol Infect Dis 2020 May 3;39(5):903-913. Epub 2020 Jan 3.

CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Barcelona, Spain.

Invasive aspergillosis (IA) is a severe life-threatening infection with challenges in therapy. The aim was to evaluate the level of evidence (LOE) supporting recommendations in clinical practice guidelines (CPGs) of IA and changes over time. Search on CPG on IA released between 2000 and 2019 was done. Read More

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http://dx.doi.org/10.1007/s10096-019-03794-7DOI Listing
May 2020
2.668 Impact Factor

Complex chest wall wound managed by a novel technique of thoracoplasty.

BMJ Case Rep 2019 Dec 29;12(12). Epub 2019 Dec 29.

Division of Trauma Surgery and Critical Care, Department of Surgical Disciplines, JPN Apex Trauma Centre, New Delhi, Delhi, India.

Thoracoplasty is a procedure to collapse the chest wall over a residual space in the thoracic cavity in order to abolish and avoid the complications associated with this dead space. Although effective in achieving this, the procedure is crippled by poor cosmetic appearance and functional outcome. We report a case of recalcitrant complex chest wall defect with a large cavity, marred by visible heart and poor availability of local muscles, that was successfully managed by a novel technique of thoracoplasty with acceptable postoperative appearance and function. Read More

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http://dx.doi.org/10.1136/bcr-2019-230782DOI Listing
December 2019

Lethal thrombosis of the iliac artery caused by Aspergillus fumigatus after liver transplantation: case report and review of the literature.

BMC Surg 2019 Dec 27;19(1):200. Epub 2019 Dec 27.

Department of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Medical Center Schleswig-Holstein (UKSH), Campus Kiel, and Christian-Albrecht University (CAU), Arnold-Heller-Str. 3, 24105, Kiel, Germany.

Background: Aspergillus fumigatus infections frequently occur after solid organ transplantation. Yet, a fungal thrombosis after liver transplantation is an exceptional finding.

Case Presentation: We report on a 44-year-old female with an aspergillosis after liver transplantation for autoimmune hepatitis. Read More

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http://dx.doi.org/10.1186/s12893-019-0668-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935117PMC
December 2019

First case of a dog infected with in Australasia.

N Z Vet J 2020 Jul 29;68(4):231-237. Epub 2020 Jan 29.

The Animal Hospital at Murdoch University, Murdoch, WA, Australia.

A 2-year-old Rottweiler dog from Perth (WA, Australia) was referred for assessment of a chronic productive cough and weight loss. Severely enlarged bilateral superficial cervical lymph nodes and severely enlarged abdominal organs were present. The body condition score was poor and there was moderate muscle wasting. Read More

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http://dx.doi.org/10.1080/00480169.2019.1706659DOI Listing

Algorithm-aided diagnosis of chronic pulmonary aspergillosis in low- and middle-income countries by use of a lateral flow device.

Eur J Clin Microbiol Infect Dis 2020 Jan 6;39(1):1-3. Epub 2019 Dec 6.

Department of Internal Medicine, Makerere University College of Health Sciences, Makerere University, Kampala, Uganda.

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http://dx.doi.org/10.1007/s10096-019-03782-xDOI Listing
January 2020
2.668 Impact Factor

Hemoptysis from complex pulmonary aspergilloma treated by cavernostomy and thoracoplasty.

BMC Surg 2019 Dec 5;19(1):187. Epub 2019 Dec 5.

Department of Epidemiology, Vietnam Military Medical University, Hanoi, Vietnam.

Background: In high-risk patients with complex pulmonary aspergilloma but unable for lung resection, cavernostomy and thoracoplasty could be performed. This study aimed to evaluate this surgery compared two compressing materials.

Methods: A total of 63 in high-risk patients who suffered from hemoptysis due to complex pulmonary aspergilloma and underwent cavernostomy and thoracoplasty surgery from November 2011 to September 2018 at Pham Ngoc Thach hospital were evaluated prospectively studied. Read More

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http://dx.doi.org/10.1186/s12893-019-0650-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894504PMC
December 2019
1.240 Impact Factor

Pulmonary aspergilloma: from classification to management.

Asian Cardiovasc Thorac Ann 2020 Jan 4;28(1):33-38. Epub 2019 Dec 4.

Department of Thoracic Surgery, CHU Hassan II, Fez, Morocco.

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http://dx.doi.org/10.1177/0218492319895113DOI Listing
January 2020
4 Reads

Expanding the spectrum of chronic necrotising (semi-invasive) aspergillosis: a series of eight cases presenting as radiologically solid lung nodules mimicking malignancy.

Histopathology 2020 Apr 17;76(5):685-697. Epub 2020 Mar 17.

Department of Thoracic Radiology, Cleveland Clinic, Cleveland, OH, USA.

Aim: To clinicopathologically characterise a subset of aspergillosis cases characterised by radiologically solid lung nodules.

Methods And Results: We reviewed our archives for lung biopsies/resections with fungal hyphae on histology. Cases classifiable as a well-established form of aspergillosis were excluded. Read More

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http://dx.doi.org/10.1111/his.14037DOI Listing

The fate of aspergilloma patients after surgical treatment-experience from 22 cases.

J Thorac Dis 2019 Oct;11(10):4298-4307

Heart and Lung Center, Helsinki University Hospital, Helsinki University, Helsinki, Finland.

Background: Patients with pulmonary aspergillomas occasionally undergo surgery but it is somewhat unclear who of these patients benefit from surgical treatment.

Methods: We retrospectively evaluated all 22 patients that underwent surgery in Helsinki University Central Hospital between 2004 and 2017. We assessed their clinical backgrounds, anti-fungal medication, indication for surgery, complications, recurrent infections and survival. Read More

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http://dx.doi.org/10.21037/jtd.2019.09.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837975PMC
October 2019

Surgical resection for persistent localized pulmonary fungal infection prior to allogeneic hematopoietic stem cell transplantation: Analysis of six cases.

J Infect Chemother 2020 Feb 15;26(2):175-180. Epub 2019 Nov 15.

Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan. Electronic address:

Objective: Although invasive fungal disease (IFD) is an important complication in allogeneic hematopoietic stem cell transplantation (HSCT), the clinical significance of surgery, including the role of surgical resection for persistent pulmonary fungal disease prior to allogeneic HSCT in the current era with a variety of available antifungal agents, is controversial. We investigated the role of surgical resection.

Methods: We retrospectively investigated six patients who underwent surgical resection of suspected pulmonary fungal disease prior to allogeneic HSCT between April 2007 and June 2016 at our medical center. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.08.003DOI Listing
February 2020

Diagnosis and outcome of resected solitary pulmonary nodules after liver transplantation.

Jpn J Clin Oncol 2020 Feb;50(2):193-197

Department of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.

Objective: Solitary pulmonary nodules after liver transplantation are challenging clinical problems. Herein, we report the causes and clinical courses of resected solitary pulmonary nodules in patients who underwent liver transplantation.

Methods: We retrospectively obtained medical records of 68 patients who underwent liver transplantation between March 2009 and June 2016. Read More

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http://dx.doi.org/10.1093/jjco/hyz159DOI Listing
February 2020

Successful Treatment of Severe Aspergillosis with Isavuconazole Therapy after Allogeneic Stem Cell Transplantation.

Chemotherapy 2019 4;64(2):57-61. Epub 2019 Sep 4.

Department of Hematology, Hospital General Universitario Gregorio Marañon, Madrid, Spain.

Invasive fungal infections are one of the main infectious complications in allogeneic stem cell transplantation (SCT). Triazoles (voriconazole, posaconazole) are the main prophylactic and therapeutic options for the treatment of invasive aspergillosis. However, pharmacological interactions and hepatotoxicity limit its use. Read More

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http://dx.doi.org/10.1159/000502279DOI Listing
November 2019
2 Reads

Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. An Official American Thoracic Society Clinical Practice Guideline.

Am J Respir Crit Care Med 2019 09;200(5):535-550

Fungal infections are of increasing incidence and importance in immunocompromised and immunocompetent patients. Timely diagnosis relies on appropriate use of laboratory testing in susceptible patients. The relevant literature related to diagnosis of invasive pulmonary aspergillosis, invasive candidiasis, and the common endemic mycoses was systematically reviewed. Read More

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http://dx.doi.org/10.1164/rccm.201906-1185STDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727169PMC
September 2019
3 Reads

Prevalence and outcome of invasive pulmonary aspergillosis in critically ill patients with liver cirrhosis: an observational study.

Sci Rep 2019 08 15;9(1):11919. Epub 2019 Aug 15.

Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.

Invasive pulmonary aspergillosis (IPA) is an important cause of morbidity/mortality in critically ill patients with endstage liver disease. Therefore, aim of this study is to predict the prevalence and outcome of IPA in critically ill patients with underlying liver cirrhosis and evaluation of the necessity Glactomannan (GM) screening in serum and bronchoalveolar lavage (BAL) in this cohort. In total 12 out of 84 patients (14%) had probable IPA. Read More

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http://dx.doi.org/10.1038/s41598-019-48183-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695439PMC
August 2019
2 Reads

Invasive tracheal aspergillosis after chemoradiotherapy treatment.

Respirol Case Rep 2019 Oct 7;7(7):e00473. Epub 2019 Aug 7.

Department of Thoracic Medicine Royal Adelaide Hospital Adelaide South Australia Australia.

Invasive tracheobronchial aspergillosis is a rare disease with most reported cases in the literature occurring in immunocompromised hosts. We report an unusual case of a patient with persistent cough and dyspnoea in the context of prior chemoradiotherapy for primary lung cancer. Chest computed tomography (CT) demonstrated an abnormal soft tissue mass surrounding the trachea and carina, with focal moderate fluorodeoxyglucose (FDG) activity on positron emission tomography (PET) scan. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rcr2.473
Publisher Site
http://dx.doi.org/10.1002/rcr2.473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685346PMC
October 2019
3 Reads

Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry.

Lancet Glob Health 2019 09;7(9):e1269-e1279

Scottish Centre for Respiratory Research, University of Dundee, Dundee, UK. Electronic address:

Background: Bronchiectasis is a common but neglected chronic lung disease. Most epidemiological data are limited to cohorts from Europe and the USA, with few data from low-income and middle-income countries. We therefore aimed to describe the characteristics, severity of disease, microbiology, and treatment of patients with bronchiectasis in India. Read More

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http://dx.doi.org/10.1016/S2214-109X(19)30327-4DOI Listing
September 2019
10 Reads

Development of Allergic Bronchopulmonary Aspergillosis in a Patient with Crohn's Disease.

Intern Med 2019 Oct 27;58(19):2835-2838. Epub 2019 Jun 27.

Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan.

Allergic bronchopulmonary aspergillosis (ABPA) is an eosinophilic inflammatory condition characterized by exaggerated immune responses to the fungal genus Aspergillus. Pulmonary manifestations in patients with Crohn's disease (CD) are frequent comorbidities. A 66-year-old man with CD treated with an anti-tumor necrosis factor-α antibody presented with dyspnea. Read More

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http://dx.doi.org/10.2169/internalmedicine.2785-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815903PMC
October 2019
9 Reads

Species identification, antifungal susceptibility, and clinical feature association of Aspergillus section Nigri isolates from the lower respiratory tract.

Med Mycol 2020 Apr;58(3):310-314

Division of Clinical Research, Medical Mycology Research Center, Chiba University, Chiba, Japan.

Species of Aspergillus section Nigri are generally identified by molecular genetics approaches, whereas in clinical practice, they are classified as A. niger by their morphological characteristics. This study aimed to investigate whether the species of Aspergillus section Nigri isolated from the respiratory tract vary depending on clinical diagnosis. Read More

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http://dx.doi.org/10.1093/mmy/myz072DOI Listing
April 2020
8 Reads

Diagnosis of Fungal Infections. A Systematic Review and Meta-Analysis Supporting American Thoracic Society Practice Guideline.

Ann Am Thorac Soc 2019 09;16(9):1179-1188

Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.

Prompt diagnosis of invasive fungal infections is important because of the associated morbidity and mortality; however, diagnosis is challenging because of the nonspecific symptoms and radiographic findings. To conduct a systematic review and meta-analysis of studies that evaluated the diagnostic accuracy of serum and bronchoalveolar lavage (BAL) galactomannan (GM) and serum or BAL polymerase chain reaction (PCR) in patients with suspected invasive aspergillosis (IA), β-d-glucan in critically ill patients at risk for candidiasis or candidemia, and serology testing and antigen detection in patients with endemic mycoses (histoplasmosis, blastomycosis, and coccidioidomycosis). Studies were selected and appraised by pairs of reviewers. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201811-766OCDOI Listing
September 2019
12 Reads

Fungal endocarditis: what do we know in 2019?

Kardiol Pol 2019 Aug 19;77(7-8):670-673. Epub 2019 Jun 19.

Department of Microbiology, Goa Medical College, Goa, India

Fungal endocarditis (FE) is an infrequent but a lethal condition. Candida and Aspergillus species are the 2 most commonly implicated pathogenic fungi. Clinical presentation is most often that of a fever of unknown origin, which is hard to differentiate from bacterial endocarditis. Read More

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http://dx.doi.org/10.33963/KP.14869DOI Listing
August 2019
10 Reads

eradication therapy and risk of acquiring in young children with cystic fibrosis.

Thorax 2019 08 15;74(8):740-748. Epub 2019 Jun 15.

School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia

Background: While detection rates in adults, adolescents and older children with cystic fibrosis (CF) have increased, the risk of acquiring this fungal pathogen in young children is unknown.

Aim: To determine the risk and explanatory factors of acquiring in children with CF by age 5 years.

Methods: Cross-sectional analysis of clinical, bronchoalveolar lavage and treatment data from the Australasian Cystic Fibrosis Bronchoalveolar Lavage study was used to identify predictive factors for detecting at age 5 years. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-211548DOI Listing
August 2019
2 Reads

Pulmonary aspergilloma: surgical outcome of 79 patients in a Moroccan center.

Asian Cardiovasc Thorac Ann 2019 Jul 5;27(6):476-480. Epub 2019 Jun 5.

1 Department of Thoracic Surgery, Centre Hospitalier Universitaire Hassan II, Fez, Morocco.

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http://dx.doi.org/10.1177/0218492319855492DOI Listing
July 2019
5 Reads

Aspergillus terreus spondylodiscitis following an abdominal stab wound: a case report.

J Med Case Rep 2019 Jun 5;13(1):172. Epub 2019 Jun 5.

Department of Orthopaedic Surgery, Graduate School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa City, Ishikawa, 920-8641, Japan.

Background: Aspergillus terreus, a saprophytic fungus, is recognized as an emerging pathogen in various infections in humans. However, bone and joint involvement is uncommon. To the best of our knowledge, only seven cases of spondylodiscitis caused by Aspergillus terreus have been reported previously in humans. Read More

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http://dx.doi.org/10.1186/s13256-019-2109-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549268PMC
June 2019
12 Reads

Uniportal Video-assisted Thoracoscopic Surgery for Pulmonary Aspergilloma: A Report of 5 Cases.

Surg Laparosc Endosc Percutan Tech 2019 Aug;29(4):e37-e40

Department of Thoracic Surgery, Marmara University Istanbul Pendik Training and Research Hospital, Istanbul, Turkey.

Pulmonary aspergilloma is an uncommon pulmonary disease that complicated with many other respiratory disorders. Despite advances in medication, surgical treatment continues to form the basis of aspergilloma treatment. However, the use of uniportal video-assisted thoracoscopic surgery is extremely limited in pulmonary aspergilloma. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000663DOI Listing

Significance of the Reverse Halo Sign in Immunocompromised Patients.

AJR Am J Roentgenol 2019 09 30;213(3):549-554. Epub 2019 Apr 30.

Department of Radiology, Division of Thoracic Imaging, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.

The purpose of this study is to assess the most common causes of the reverse halo sign (RHS) in immunocompromised patients and to identify clinicoradiologic features that help in achieving a specific diagnosis. This retrospective study included 70 patients with hematologic malignancy, neutropenia, or history of solid organ transplant or stem cell transplant who had the RHS at chest CT. Absolute neutrophil count, imaging features of the RHS, and presence of pleural effusions were noted and correlated with the specific diagnosis. Read More

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https://www.ajronline.org/doi/10.2214/AJR.19.21273
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http://dx.doi.org/10.2214/AJR.19.21273DOI Listing
September 2019
30 Reads

Chronic Nodular Pulmonary Aspergillosis in a Patient with Rheumatoid Arthritis.

Intern Med 2019 1;58(7):979-984. Epub 2019 Apr 1.

National Institute of Infectious Diseases, Japan.

Chronic pulmonary aspergillosis, which features nodular lesions known as Aspergillus nodules, is a relatively uncommon disorder. We herein report a case of slowly progressing chronic multiple nodular pulmonary aspergillosis in a 59-year-old man with rheumatoid arthritis, dyspnea, and fatigue. One nodule was surgically resected. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/58/7/5
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http://dx.doi.org/10.2169/internalmedicine.1918-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478981PMC
May 2019
24 Reads

Calcified intracavitary mass: a rare presentation of aspergilloma.

J Bras Pneumol 2019 Mar 25;45(2):e20180396. Epub 2019 Mar 25.

. Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil.

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http://dx.doi.org/10.1590/1806-3713/e20180396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733750PMC
March 2019
3 Reads

Thoracostomy showing pleural aspergillosis.

Lancet Infect Dis 2019 03;19(3):337

Infectious Diseases Department, Hospital Clinic of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30599-1DOI Listing
March 2019
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Successful control of exacerbation of Allergic Bronchopulmonary Aspergillosis due to Aspergillus terreus in a cystic fibrosis patient with short-term adjunctive therapy with voriconazole: A case report.

J Mycol Med 2019 Jun 16;29(2):189-192. Epub 2019 Feb 16.

Invasive Fungi Research Center (IFRC)/ Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

A 12-year-old boy with cystic fibrosis (CF) and a history of glucocorticoid-dependent allergic bronchopulmonary aspergillosis (ABPA) was referred to our hospital. The ABPA was diagnosed when he was 8 years old and he had been treated with several course of oral glucocorticoids for recurrent exacerbations. He was readmitted when aged 12 with a history of worsening shortness of breath and chest tightness. Read More

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http://dx.doi.org/10.1016/j.mycmed.2019.02.001DOI Listing
June 2019
5 Reads

[Coexistence of Pulmonary Aspergillosis and Hydatidosis. Case report].

Rev Peru Med Exp Salud Publica 2018 Oct-Dec;35(4):689-694

Hospital Edgardo Rebagliati Martins, EsSalud. Lima, Perú.

Hydatidosis is a zoonosis caused by the parasite Echinococcus granulosus and Peru is an endemic zone for this infection. We present the case of a 33-year old woman from the region of Ica who, during gestation, was diagnosed with liver and pulmonary hydatidosis. After gestation was terminated, she was referred with thoracic drainage tube, dyspnea, and thoracic pain in right hemithorax, with progressive course and tomographic image of thorax showing right posterior basal pulmonary cyst. Read More

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http://dx.doi.org/10.17843/rpmesp.2018.354.3437DOI Listing
September 2019
3 Reads

Chronic pulmonary aspergillosis commonly complicates treated pulmonary tuberculosis with residual cavitation.

Eur Respir J 2019 03 18;53(3). Epub 2019 Mar 18.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Chronic pulmonary aspergillosis (CPA) complicates treated pulmonary tuberculosis (TB), with high 5-year mortality. We measured CPA prevalence in this group.398 Ugandans with treated pulmonary TB underwent clinical assessment, chest radiography and -specific IgG measurement. Read More

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http://dx.doi.org/10.1183/13993003.01184-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422837PMC
March 2019
8 Reads

Evaluation of 3 T lung magnetic resonance imaging in children with allergic bronchopulmonary aspergillosis: Pilot study.

Eur J Radiol 2019 Feb 30;111:88-92. Epub 2018 Dec 30.

Department of Pulmonary Medicine, PGIMER, Chandigarh, India.

Objective: To evaluate the diagnostic performance of 3 T lung magnetic resonance imaging (MRI) in children with allergic bronchopulmonary aspergillosis (ABPA).

Materials And Methods: This study protocol was approved by the institutional ethics committee. From October 2015 to January 2018, we prospectively evaluated twenty-seven consecutive children with ABPA. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.12.021DOI Listing
February 2019
11 Reads