1,068 results match your criteria Aspergillosis Thoracic


Successful control of exacerbation of Allergic Bronchopulmonary Aspergillosis due to Aspergillus terreus in a cystic fibrosis patient with short-term adjunctive therapy with voriconazole: A case report.

J Mycol Med 2019 Feb 16. Epub 2019 Feb 16.

Invasive Fungi Research Center (IFRC)/ Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

A 12-year-old boy with cystic fibrosis (CF) and a history of glucocorticoid-dependent allergic bronchopulmonary aspergillosis (ABPA) was referred to our hospital. The ABPA was diagnosed when he was 8 years old and he had been treated with several course of oral glucocorticoids for recurrent exacerbations. He was readmitted when aged 12 with a history of worsening shortness of breath and chest tightness. Read More

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http://dx.doi.org/10.1016/j.mycmed.2019.02.001DOI Listing
February 2019

[Coexistence of Pulmonary Aspergillosis and Hydatidosis. Case report].

Rev Peru Med Exp Salud Publica 2018 Oct-Dec;35(4):689-694

Hospital Edgardo Rebagliati Martins, EsSalud. Lima, Perú.

Hydatidosis is a zoonosis caused by the parasite Echinococcus granulosus and Peru is an endemic zone for this infection. We present the case of a 33-year old woman from the region of Ica who, during gestation, was diagnosed with liver and pulmonary hydatidosis. After gestation was terminated, she was referred with thoracic drainage tube, dyspnea, and thoracic pain in right hemithorax, with progressive course and tomographic image of thorax showing right posterior basal pulmonary cyst. Read More

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http://dx.doi.org/10.17843/rpmesp.2018.354.3437DOI Listing
January 2018
1 Read

Chronic pulmonary aspergillosis commonly complicates treated pulmonary tuberculosis with residual cavitation.

Eur Respir J 2019 Jan 31. Epub 2019 Jan 31.

Division of Infection, Immunity & Respiratory Medicine, Faculty of Biology, Medicine & Health, The University of Manchester, Manchester Academic Health Science Centre, UK.

Chronic pulmonary aspergillosis (CPA) complicates treated pulmonary tuberculosis, with high 5-year mortality. We measured CPA prevalence in this group.398 Ugandans with treated pulmonary tuberculosis underwent clinical assessment, chest X-ray and -specific IgG measurement. Read More

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http://dx.doi.org/10.1183/13993003.01184-2018DOI Listing
January 2019
2 Reads

Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

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http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
1 Read

A case of invasive pulmonary aspergillosis during treatment for acute exacerbation of interstitial lung disease.

Infect Dis Rep 2018 Nov 5;10(3):7785. Epub 2018 Dec 5.

Thoracic Surgery, Nagoya Tokushukai General Hospital, Japan.

Prolonged immunosuppressive therapy is a risk factor for invasive pulmonary aspergillosis. We report a case of a 79-yearold man who underwent immunosuppressive therapy with methylprednisolone and cyclosporine for an acute exacerbation of interstitial lung disease. Ten days after initiation of immunosuppressive therapy, the patient reported night sweats and purulent sputum, and chest computed tomography scan revealed consolidation. Read More

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http://dx.doi.org/10.4081/idr.2018.7785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315312PMC
November 2018
2 Reads

Allergic bronchopulmonary aspergillosis screening in bronchiectasis: is there always a precise answer to a clear question?

Eur Ann Allergy Clin Immunol 2019 Jan;51(1):41-43

Cardio-Thoracic-Vascular Department, University of Milano Bicocca, Respiratory Unit, San Gerardo Hospital, ASST Monza, Monza, Italy.

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.62DOI Listing
January 2019
2 Reads

Is adjuvant antifungal therapy after video-assisted thoracic surgery for pulmonary aspergilloma necessary?

J Thorac Dis 2018 Nov;10(11):6060-6065

Department of Thoracic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Background: The aim of this current retrospective study was to assess the necessity of postoperative antifungal therapy for pulmonary aspergilloma (PA) patients who underwent video-assisted thoracic surgery (VATS) lung resection.

Methods: We enrolled 22 PA patients who underwent VATS lung resection between 2014 and 2018. Of these, 12 patients were prescribed antifungal agents during the perioperative period (group A), and the other 10 were treated with surgery alone without any antifungal therapy postoperatively (group B). Read More

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http://jtd.amegroups.com/article/view/24765/19084
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http://dx.doi.org/10.21037/jtd.2018.09.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297433PMC
November 2018
3 Reads

Development of Squamous Cell Carcinoma After Pulmonary Aspergillosis in the Native Lung of a Lung Transplant Recipient: A Case Report.

Transplant Proc 2018 Dec 9;50(10):4080-4084. Epub 2018 Aug 9.

Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona. Electronic address:

Lung transplant recipients have a significant incidence of posttransplant lung nodules. Such nodules can occur from various etiologies, both in the lung allograft or in the native lung. They most commonly originate from infections, such as Pseudomonas or Aspergillus species, or from posttransplant lymphoproliferative disorder. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183106
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http://dx.doi.org/10.1016/j.transproceed.2018.07.034DOI Listing
December 2018
9 Reads

Integrating anatomo-physiological changes and pharmacogenomics in anti-infective therapy management: is it a major concern?

Br J Clin Pharmacol 2019 Jan 16;85(1):263-265. Epub 2018 Nov 16.

Pôle Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, F-38000, Grenoble, France.

Success of anti-infective therapy is a major challenge in some patients given anatomo-physiological changes and genetic variations. In this case anecdote, we report the management strategy of a patient suffering from chronic pulmonary aspergillosis in a context of anorexia nervosa and genetic polymorphism. Read More

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http://dx.doi.org/10.1111/bcp.13785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303195PMC
January 2019
4 Reads

Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies.

Korean J Thorac Cardiovasc Surg 2018 Oct 5;51(5):350-355. Epub 2018 Oct 5.

Department of General Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.

Background: The complication rate of fungal disease is higher among patients with hematological malignancies. We investigated the clinicobacteriological outcomes of resected pulmonary fungal infections complicating hematological malignancies.

Methods: Between 2001 and 2017, 21 patients with pulmonary fungal infections complicating hematological malignancies underwent resection, and their clinical records and survival were retrospectively reviewed. Read More

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http://www.kjtcvs.org/journal/view.html?doi=10.5090/kjtcs.20
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http://dx.doi.org/10.5090/kjtcs.2018.51.5.350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200165PMC
October 2018
12 Reads

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0100-3984.2017.0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198837PMC
October 2018
18 Reads

Invasive mediastinal aspergillosis presenting as superior vena cava syndrome in an immunocompetent patient.

BMJ Case Rep 2018 Sep 12;2018. Epub 2018 Sep 12.

Department of Pulmonology and Critical Care, Aga Khan University Hospital, Karachi, Pakistan.

Invasive aspergillosis (IA) is a disease of the immunocompromised with a predilection for the lungs, although dissemination to all organs is possible. Its diagnosis remains a challenge due to the absence of specific clinical manifestations and laboratory findings. In most cases, diagnosis is eventually made via invasive methods. Read More

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http://dx.doi.org/10.1136/bcr-2018-225614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144180PMC
September 2018
5 Reads

Clinical risk factors for invasive aspergillosis in lung transplant recipients: Results of an international cohort study.

J Heart Lung Transplant 2018 Oct 21;37(10):1226-1234. Epub 2018 Jun 21.

Multi-Organ Transplant Program, Division of Infectious Diseases, University Health Network, Toronto, Ontario, Canada. Electronic address:

Background: Invasive aspergillosis (IA) is a frequent complication in lung transplant recipients (LTRs). Clinical risk factors for IA have not been fully characterized, especially in the era of extensive anti-fungal prophylaxis. The primary objective of this study was to evaluate the clinical risk factors associated with IA in LTRs. Read More

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http://dx.doi.org/10.1016/j.healun.2018.06.008DOI Listing
October 2018
8 Reads
6.650 Impact Factor

Two cases of cavitary lung cancer with concomitant chronic infectious disease.

Respir Med Case Rep 2018 11;24:122-124. Epub 2018 May 11.

Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

The existence of a lung cavity on chest radiographs suggests the presence of lung disease, including benign or malignant disease. Lung cancer, tuberculosis, and fungal infection are all known for developing lung cavity. In addition, there are some characteristic findings in the differential diagnosis of cavitary disease, although these cavitary diseases often coexist. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010638PMC
May 2018
4 Reads

Lung Parenchymal and Endobronchial Metastases From Ovarian Carcinoma.

J Bronchology Interv Pulmonol 2018 Jul;25(3):235-238

Medical Oncology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu, India.

Ovarian cancer is the seventh most common cancer in women and the eighth most common cause of cancer death in the world with an overall 5-year survival rate of <50%. (1) The most common age of presentation is at the perimenopausal age group and two-thirds of them present with advanced stage of disease. (2) Thoracic metastases occur in up to 50% of patients. Read More

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http://dx.doi.org/10.1097/LBR.0000000000000463DOI Listing
July 2018
18 Reads

Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis.

Oncotarget 2018 Jun 1;9(42):26724-26736. Epub 2018 Jun 1.

Department of Hematology and Cell Therapy, University Hospital, F-33000 Bordeaux, France.

Posaconazole prophylaxis has demonstrated efficacy in the prevention of invasive aspergillosis during prolonged neutropenia following acute myeloid leukemia induction chemotherapy. Antifungal treatment decreases serum galactomannan enzyme immunoassay diagnostic accuracy that could delay the diagnosis and treatment. We retrospectively studied patients with acute myeloid leukemia who underwent intensive chemotherapy and antifungal prophylaxis by posaconazole oral suspension. Read More

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http://dx.doi.org/10.18632/oncotarget.25477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003556PMC
June 2018
12 Reads

Diagnostic cut-off of Aspergillus fumigatus-specific IgG in the diagnosis of chronic pulmonary aspergillosis.

Mycoses 2018 Oct 12;61(10):770-776. Epub 2018 Jul 12.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Aspergillus fumigatus-specific IgG is pivotal in making the diagnosis of chronic pulmonary aspergillosis (CPA). However, the cut-off value for A. fumigatus-specific IgG remains unknown. Read More

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http://doi.wiley.com/10.1111/myc.12815
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http://dx.doi.org/10.1111/myc.12815DOI Listing
October 2018
9 Reads
1.805 Impact Factor

Aspergillus Sternomyelitis Developed from Chronic Pulmonary Aspergillosis as a Late Complication to Lobectomy for Lung Cancer.

Intern Med 2018 Oct 6;57(20):2991-2994. Epub 2018 Jun 6.

Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan.

Progressive fibrobullous changes in the residual lobes are sometimes observed after lobectomy. Aspergillus osteomyelitis is an uncommon infection that rarely occurs sternally. A 70-year-old man who had undergone lobectomy 12 years earlier was admitted to our hospital for chest pain. Read More

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http://dx.doi.org/10.2169/internalmedicine.0334-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232016PMC
October 2018
11 Reads

Nontuberculous mycobacterial and Aspergillus infections among cadaveric lung transplant recipients in Japan.

Respir Investig 2018 May 4;56(3):243-248. Epub 2018 Feb 4.

Department of Respiratory Medicine, National Hospital Organization, Kinki-Chuo Chest Medical Center, 1180 Nagasone-Cho, Kita-Ku, Sakai City, Osaka 591-8555, Japan. Electronic address:

Background: Lung transplantation is an effective treatment modality for respiratory failure. Chronic lung infections, including infections caused by nontuberculous mycobacteria (NTM) and Aspergillus, are difficult to control, and uncontrolled infections are relative contraindications for lung transplantation. However, few reports have documented the incidence and outcome of these infections in lung transplant recipients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22125345183000
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http://dx.doi.org/10.1016/j.resinv.2017.12.010DOI Listing
May 2018
4 Reads

[Assessment of Surgical Treatment for Chronic Pulmonary Aspergillosis].

Kyobu Geka 2018 May;71(5):323-328

Department of Thoracic Surgery, Sapporo City General Hospital, Sapporo, Japan.

Objectives: The purpose of this study is to assess retrospectively our treatment strategy for chronic pulmonary aspergillosis(CPA).

Patients And Method: From 2002 to 2015, 11 patients underwent pulmonary resection for CPA in our hospital. Six patients were diagnosed simple pulmonary aspergilloma (SPA) and 5 were chronic progressive pulmonary aspergillosis(CPPA). Read More

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May 2018
1 Read

Isolated Acute Appendicitis Caused by Aspergillus in a Patient Who Underwent Lung Transplantation: A Case Report.

Transplant Proc 2018 May 11;50(4):1199-1201. Epub 2018 Apr 11.

Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea; Department of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Invasive aspergillosis is an important cause of morbidity and mortality in patients who have undergone lung transplantation. Aspergillus infections usually involve the respiratory tract, with vascular invasion and subsequent dissemination. However, acute appendicitis associated with localized aspergillosis is rare, especially among patients who have undergone prophylaxis with voriconazole. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.01.033DOI Listing
May 2018
10 Reads

Pulmonary sarcoidosis.

Lancet Respir Med 2018 05 3;6(5):389-402. Epub 2018 Apr 3.

Royal Brompton and Harefield National Health Service Foundation Trust, Interstitial Lung Disease Unit, London, UK.

Sarcoidosis is a granulomatous disease of unknown cause, occurs worldwide and has a highly variable prevalence. The disease is typically dominant in the lungs, although it can affect virtually any organ and is unpredictable in its clinical course. The severity of pulmonary sarcoidosis ranges from incidentally discovered radiographic abnormalities in asymptomatic patients to a chronic progressive disease that is refractory to treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132600183006
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http://dx.doi.org/10.1016/S2213-2600(18)30064-XDOI Listing
May 2018
12 Reads

Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response.

Thorax 2018 08 5;73(8):758-768. Epub 2018 Apr 5.

Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea.

Background: Respiratory fungal exposure is known to be associated with severe allergic lung inflammation. Airway epithelium is an essential controller of allergic inflammation. An innate immune recognition receptor, nucleotide-binding domain, leucine-rich-containing family, pyrin-domain-containing-3 (NLRP3) inflammasome, and phosphoinositide 3 kinase (PI3K)-δ in airway epithelium are involved in various inflammatory processes. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2017-210326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204980PMC
August 2018
9 Reads
1 Citation
8.290 Impact Factor

[Post-traumatic pulmonary aspergilloma].

Rev Mal Respir 2018 Mar 27;35(3):342-346. Epub 2018 Mar 27.

CS10217, clinique universitaire de pédiatrie, CHU de Grenoble-Alpes, hôpital Couple-Enfants, 38043 Grenoble cedex 9, France; Inserm 1209, institut pour l'avancée des biosciences, 38042 Grenoble cedex 9, France. Electronic address:

Introduction: Aspergillomas occur due to colonization of a pre-existing pulmonary, bronchial or pleural cavity by Aspergillus spp. Often asymptomatic, this pathology can reveal itself by recurrent haemoptysis or when bacterial superinfections occur. Aspergillomas occurring in post-traumatic cavities are rare and their management is poorly codified. Read More

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http://dx.doi.org/10.1016/j.rmr.2017.05.005DOI Listing
March 2018
1 Read

A strategy for prevention of fungal infections in lung transplantation: Role of bronchoalveolar lavage fluid galactomannan and fungal culture.

J Heart Lung Transplant 2018 Jul 16;37(7):886-894. Epub 2018 Feb 16.

Multi-Organ Transplant Program, University of Toronto, University Health Network, Toronto, Ontario, Canada; Division of Respirology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Background: The optimal strategy for prevention of invasive fungal infections in lung transplant recipients remains undetermined. We studied strategies based on bronchoalveolar lavage fungal culture and galactomannan for prevention of invasive aspergillosis in lung transplant recipients.

Methods: Consecutive lung transplant recipients were evaluated during the period January 2010 to September 2014. Read More

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http://dx.doi.org/10.1016/j.healun.2018.02.006DOI Listing
July 2018
10 Reads

Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.

Clin Microbiol Infect 2018 May 12;24 Suppl 1:e1-e38. Epub 2018 Mar 12.

First Department of Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece; German Centre for Infection Research (DZIF) partner site Bonn-Cologne, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany; Clinical Trials Center Cologne, University Hospital of Cologne, Cologne, Germany; ESCMID Fungal Infection Study Group (EFISG); European Confederation of Medical Mycology (ECMM); ESCMID European Study Group for Infections in Compromised Hosts (ESGICH). Electronic address:

The European Society for Clinical Microbiology and Infectious Diseases, the European Confederation of Medical Mycology and the European Respiratory Society Joint Clinical Guidelines focus on diagnosis and management of aspergillosis. Of the numerous recommendations, a few are summarized here. Chest computed tomography as well as bronchoscopy with bronchoalveolar lavage (BAL) in patients with suspicion of pulmonary invasive aspergillosis (IA) are strongly recommended. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.01.002DOI Listing
May 2018
8 Reads

Feasibility of surgery for pulmonary aspergilloma: analysis of the operative modes.

Gen Thorac Cardiovasc Surg 2018 May 14;66(5):276-283. Epub 2018 Mar 14.

Department of General Thoracic Surgery, Juntendo University School of Medicine, 1-3, Hongo 3-chome, Bunkyo-ku, Tokyo, 113-8431, Japan.

Purpose: We evaluated the feasibility of surgery for pulmonary aspergilloma.

Methods: We retrospectively evaluated 35 surgical patients with pulmonary aspergilloma. The clinical characteristics and perioperative surgical morbidity were compared based on the operative modes. Read More

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http://dx.doi.org/10.1007/s11748-018-0904-3DOI Listing
May 2018
5 Reads

Radiologically Occult Invasive Pulmonary Aspergillosis in a Patient With Liver Transplant.

Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):176-178

Department of Pulmonary Diseases, Baskent University Faculty of Medicine, Ankara, Turkey.

Invasive pulmonary aspergillosis is an infection seen in patients receiving intensive immunosuppressive regimens, such as transplant recipients. Some risk factors that increase the incidence of infection have been determined, and patients defined as having high risk are recommended to take antifungal prophylaxis and be monitored closely. Here, we present a liver transplant patient with mild respiratory symptoms and a normal chest radiography on day 26 posttransplant. Read More

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http://dx.doi.org/10.6002/ect.TOND-TDTD2017.P55DOI Listing
March 2018
4 Reads

[Invasive pulmonary aspergillosis].

Rev Mal Respir 2018 Feb 23;35(2):171-187. Epub 2018 Feb 23.

Service d'hématologie clinique et de thérapie cellulaire, CHU de Bordeaux, 33604 Bordeaux, France.

Introduction: Invasive pulmonary aspergillosis (IPA) is an important cause of morbidity and mortality in a wide range of patients. Early recognition and diagnosis have become a major focus in improving the management and outcomes of this life-threatening disease.

Background: IPA typically occurs during a period of severe and prolonged neutropenia. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.01.002DOI Listing
February 2018

Marked cachexia in probable invasive pulmonary aspergillosis with bronchopleural fistula.

BMJ Case Rep 2018 Jan 17;2018. Epub 2018 Jan 17.

Department of Intensive Care, Barts Health NHS Trust, St Bartholomew's Hospital, London, UK.

A 49-year-old man with a medical history of diabetes and heavy smoking was admitted to intensive care with severe bilateral pneumonia associated with marked cachexia. He developed a complex right-sided bronchopleural fistula and was transferred to our tertiary centre for consideration of surgical intervention.Despite escalation of antibiotic therapy, he did not improve and further investigations led to a diagnosis of invasive pulmonary aspergillosis. Read More

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http://dx.doi.org/10.1136/bcr-2017-222143DOI Listing
January 2018
6 Reads

Tumor shape pulmonary mucormycosis associated with sinonasal aspergillosis in a diabetic patient.

Med Mycol Case Rep 2018 Mar 1;19:13-17. Epub 2017 Sep 1.

Pneumology Department, Hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac, France.

Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. Read More

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http://dx.doi.org/10.1016/j.mmcr.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695648PMC
March 2018
9 Reads

Elevated Aspergillus-specific antibody levels among HIV infected Ugandans with pulmonary tuberculosis.

BMC Pulm Med 2017 Nov 21;17(1):149. Epub 2017 Nov 21.

The University of Manchester, Manchester, UK.

Background: The incidence of tuberculosis (TB) is high among human immunodeficiency virus (HIV) infected Ugandans. Recent evidence suggests that Chronic Pulmonary Aspergillosis and Aspergillus sensitisation might be responsible for significant mortality in patients treated for tuberculosis in Uganda.

Methods: We retrieved and tested paired serum aliquots for 101 HIV-TB co-infected patients at the beginning and week 24 of TB treatment. Read More

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http://dx.doi.org/10.1186/s12890-017-0500-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699185PMC
November 2017
11 Reads

Posaconazole liquid vs tablet formulation in lung transplant recipients.

Mycoses 2018 Mar 22;61(3):186-194. Epub 2017 Nov 22.

Department of Internal Medicine V, LMU-Munich, Munich, Germany.

Posaconazole is an extended-spectrum triazole antifungal used in the treatment and prophylaxis of Aspergillus infections. It is available as oral suspension (POS-Liq) and delayed-release tablets (POS-Tab). The aim of this longitudinal, retrospective study was to compare the clinical effectiveness, toxicity and pharmacokinetics of POS-Liq vs POS-Tab in lung transplant recipients (LTx-recipients), who were treated with both formulations subsequently. Read More

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http://doi.wiley.com/10.1111/myc.12724
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http://dx.doi.org/10.1111/myc.12724DOI Listing
March 2018
11 Reads

Massive Hemoptysis with a Fungus Ball-like Shadow in an Old Tuberculosis Cavity That Was Shown to Be a Clot by Bronchoscopy.

Intern Med 2018 Feb 1;57(3):377-381. Epub 2017 Nov 1.

Division of Respiratory Medicine, National Center for Global Health and Medicine, Japan.

Development of aspergilloma is common in cases with a fungus ball-like shadow in cavities due to old tuberculosis. Some reports have shown that blood clots tend to appear as a fungus ball-like shadow. A 71-year-old man with a history of pulmonary tuberculosis presented with a fungus ball-like shadow in an old cavity and hemoptysis. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/57/3/5
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http://dx.doi.org/10.2169/internalmedicine.8967-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827319PMC
February 2018
5 Reads

Significance of monitoring plasma concentration of voriconazole in a patient with liver failure: A case report.

Medicine (Baltimore) 2017 Oct;96(42):e8039

Liver Failure Treatment and Research Center, 302 Hospital of PLA, Xisihuanzhonglu, Beijing, China.

Rationale: Invasive pulmonary aspergillosis is associated with significant morbidity and mortality in patients with liver failure. Voriconazole (VRCZ) is recommended as a primary therapeutic agent for the treatment of invasive aspergillosis and metabolized in the liver. Now, data are still lacking on the safety and appropriate dosage of VRCZ in patients with liver failure. Read More

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http://dx.doi.org/10.1097/MD.0000000000008039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662357PMC
October 2017
14 Reads

A rare complication of chronic granulomatous disease in a child: constrictive aspergillus pericarditis.

Turk Kardiyol Dern Ars 2017 Oct;45(7):660-663

Department of Cardiovascular Surgery, Ege University Faculty of Medicine, İzmir, Turkey.

A 3-year-old girl with the diagnosis of chronic granulomatous disease (CGD) was hospitalized for bronchopneumonia and congestive heart failure. Her medical history included methylprednisolone medication for autoimmune gastric outlet obstruction. Computed tomography revealed pneumonic infiltrations and pericardial thickening. Read More

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http://dx.doi.org/10.5543/tkda.2017.52284DOI Listing
October 2017
4 Reads

Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in immunocompromised patients.

Clin Microbiol Infect 2018 Jun 29;24(6):640-645. Epub 2017 Sep 29.

Transplant Infectious Diseases, Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada; Department of Medicine, University Health Network, Toronto, Ontario, Canada. Electronic address:

Objectives: Exhaled breath condensate (EBC) is a noninvasive means of sampling the airways that has shown significant promise in the diagnosis of many disorders. There have been no reports of its usefulness in the detection of galactomannan (GM), a component of the cell wall of Aspergillus. The suitability of EBC for the detection of GM for the diagnosis of invasive aspergillosis (IA) using the Platelia Aspergillus enzyme-linked immunosorbent assay was investigated. Read More

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http://dx.doi.org/10.1016/j.cmi.2017.09.018DOI Listing
June 2018
3 Reads

Destruction and intrapulmonary migration of a rib after pulmonary aspergillosis.

Eur J Cardiothorac Surg 2017 Sep 6. Epub 2017 Sep 6.

Department of Thoracic Surgery, Virgen de las Nieves University Hospital, Granada, Spain.

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http://dx.doi.org/10.1093/ejcts/ezx329DOI Listing
September 2017
3 Reads

A Curious Case of Blood-Culture-Negative Infective Endocarditis.

J Cardiothorac Vasc Anesth 2018 02 19;32(1):e3-e5. Epub 2017 Apr 19.

Department of Anesthesiology, London Health Sciences Centre, Western University, Ontario, Canada.

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http://dx.doi.org/10.1053/j.jvca.2017.04.031DOI Listing
February 2018
6 Reads

The evolving landscape of new diagnostic tests for invasive aspergillosis in hematology patients: strengths and weaknesses.

Curr Opin Infect Dis 2017 Dec;30(6):539-544

aDepartment of Internal Medicine - Hematology and Oncology, Mannheim University Hospital, Heidelberg University, Heidelberg bSecond Department of Internal Medicine, Brandenburg University Hospital, Brandenburg, Germany cDivision of Infectious Diseases, Department of Medicine, University of California -San Diego, San Diego, California, USA dSection of Infectious Diseases and Tropical Medicine, Department of Internal Medicine eDivision of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Purpose Of Review: The diagnosis of invasive aspergillosis in hematologic patients is a complex composite of clinical preconditions and features, imaging findings, biomarker combinations from appropriate clinical samples and microbiological and/or histological findings.

Recent Findings: Recent developments in the evolving landscape of diagnostic tests for invasive aspergillosis in adult hematology patients are highlighted.

Summary: Novel approaches and tools are currently under development. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000408DOI Listing
December 2017
10 Reads

A young immunocompetent patient with spontaneous empyema who developed severe eosinophilia.

Respir Med Case Rep 2017 30;22:220-223. Epub 2017 Aug 30.

Department of Pulmonary Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.

empyema is usually reported as a complication of surgical procedures, and spontaneous cases are quite rare. Here, we describe the case of a 16-year-old man who suddenly developed dyspnea despite previously being healthy. Chest computed tomography showed multiple mass-containing cavity lesions, pneumothorax, and pleural effusion in the left thorax. Read More

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http://dx.doi.org/10.1016/j.rmcr.2017.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587871PMC
August 2017
30 Reads

Kinetics of Radiological Response of Thoracic Invasive Fungal Disease in Chronic Granulomatous Disease.

J Clin Immunol 2017 10 1;37(7):623-625. Epub 2017 Sep 1.

Service de Maladies Infectieuses et Tropicales, Hôpital Universitaire Necker-Enfants Malades, Centre d'Infectiologie Necker Pasteur, Assistance Publique-Hôpitaux de Paris, Paris, France.

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http://link.springer.com/10.1007/s10875-017-0440-4
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http://dx.doi.org/10.1007/s10875-017-0440-4DOI Listing
October 2017
4 Reads

Postsurgical mediastinal aspergilloma masquerading as malignancy.

BMJ Case Rep 2017 Aug 7;2017. Epub 2017 Aug 7.

Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

A 70-year-old man with non-ischaemic dilated cardiomyopathy presented with symptoms of fatigue, chills and unintentional weight loss over the past 2 months. Initial evaluation revealed anaemia, peripheral leucocytosis and elevated inflammatory markers. Results of an oesophagogastroduodenoscopy, colonoscopy, blood bacterial and fungal cultures and bone marrow biopsy were negative. Read More

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http://dx.doi.org/10.1136/bcr-2017-221140DOI Listing
August 2017
7 Reads

Surgical treatment for pulmonary aspergilloma - early and long-term results.

Kardiochir Torakochirurgia Pol 2017 Jun 30;14(2):99-103. Epub 2017 Jun 30.

Department of Thoracic Surgery, Poznan University of Medical Sciences, Poznań, Poland.

Introduction: Pulmonary aspergilloma is a difficult therapeutic problem due to the low effectiveness of conservative treatment and high surgical morbidity.

Aim: To analyze the early and late results of surgical treatment for pulmonary aspergilloma.

Material And Methods: From 2005 to 2015, 49 patients were treated surgically for pulmonary aspergilloma. Read More

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http://dx.doi.org/10.5114/kitp.2017.68738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519834PMC
June 2017
4 Reads

An African American Man in His Late 30s With Lung Cancer Presenting With Persistent Cough and Hemoptysis.

Chest 2017 07;152(1):e11-e14

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN.

Case Presentation: An African American man in his late 30s was referred to the pulmonary clinic for evaluation of a persistent cough of several weeks' duration. Cough was productive of mucopurulent sputum mixed with blood. He also noted generalized weakness and dyspnea with minimal exertion. Read More

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http://dx.doi.org/10.1016/j.chest.2016.12.013DOI Listing
July 2017
4 Reads

Early-onset invasive pulmonary aspergillosis in an orthotopic heart transplant recipient.

Lung India 2017 Jul-Aug;34(4):376-379

Division of Infectious Disease, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, USA.

Invasive aspergillosis generally occurs during the first 1-6 months after heart transplantation. It has been rarely seen in the first 2 weeks postcardiac transplant. We herein describe a unique case of invasive pulmonary aspergillosis (IPA) diagnosed on day 9 postorthotopic heart transplantation. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_454_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504897PMC
July 2017
18 Reads

Bronchocentric Granulomatosis in an Immunocompetent Patient.

Arch Bronconeumol 2018 Jan 20;54(1):45-46. Epub 2017 Jun 20.

Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.arbres.2017.05.017DOI Listing
January 2018
3 Reads

Elevated Serum Beta-D-Glucan with Pseudomonas, Aspergillus, and a Partially Acid-Fast Organism in Respiratory Cultures: A Case of Hickam's Dictum Over Occam's Razor.

Mycopathologia 2017 Oct 16;182(9-10):869-872. Epub 2017 Jun 16.

Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1090, New York, NY, 10029, USA.

We describe a case of a man with ectopic Cushing's syndrome, elevated serum beta-D-glucan, and respiratory cultures with Pseudomonas, Aspergillus, and a partially acid-fast organism. Our case highlights challenges in diagnosis and management of coinfection in an immunocompromised host. Read More

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http://dx.doi.org/10.1007/s11046-017-0157-1DOI Listing
October 2017
19 Reads

Chronic pulmonary aspergillosis complicating sarcoidosis.

Eur Respir J 2017 06 15;49(6). Epub 2017 Jun 15.

Paris 13 University, EA2363, Sorbonne Paris Cité, Bobigny, France.

Chronic pulmonary aspergillosis (CPA) complicating sarcoidosis (SA) is associated with high mortality, and there is a lack of clarity regarding the relative contributions of SA or CPA.This was a retrospective single-centre study on CPA-SA.In total, 65 patients (44 men), aged 41. Read More

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http://dx.doi.org/10.1183/13993003.02396-2016DOI Listing
June 2017
18 Reads