19,055 results match your criteria Aspergillosis Thoracic


Cutaneous mucormycosis.

Transpl Infect Dis 2018 Dec 13:e13039. Epub 2018 Dec 13.

Department of Hematology, AZ Delta Roeselare.

Mucormycosis is an aggressive invasive fungal infection that occurs rarely in immunocompetent but frequently in immunocompromised patients. We present a case of a 68-year old patient with cutaneous mucormycosis due to Rhizopus pusillus. He was initially hospitalized for invasive pulmonary aspergillosis and diabetes mellitus secondary to acute graft-versus-host treatment with glucocorticoids after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. Read More

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December 2018

Treating invasive aspergillosis in patients with hematologic malignancy: diagnostic-driven approach versus empiric therapies.

BMC Infect Dis 2018 Dec 13;18(1):656. Epub 2018 Dec 13.

Department of Infectious Diseases, Infection Control & Employee Health, Unit 1460, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA.

Background: Early antifungal therapy for invasive aspergillosis (IA) has been associated with improved outcome. Traditionally, of empiric antifungal therapy has been used for clinically suspected IA. We compared outcomes of patients with hematologic malignancy and IA who were treated with voriconazole using the diagnostic driven DDA (DDA-Vori) that includes galactomannan testing vs. Read More

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December 2018

Aspergillus pseudodeflectus: a new human pathogen in liver transplant patients.

BMC Infect Dis 2018 Dec 12;18(1):648. Epub 2018 Dec 12.

Unité de Parasitologie-Mycologie, Département de Virologie, Bactériologie-Hygiène, Parasitologie-Mycologie, DHU VIC, CHU Henri Mondor, AP-HP, Créteil, France.

Background: Liver transplant recipients are at high risk of developing invasive aspergillosis and in particular by Aspergillus fumigatus which is the most commonly encountered species in this population. Other non-fumigatus Aspergillus species with reduced susceptibility to antifungal drugs can also be involved. Accurate identification associated to antifungal susceptibility testing is essential for therapy adjustment. Read More

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December 2018

Is Aspergillus lateral device ready to implement to the daily practice? The question rising from the new European Invasive Aspergillosis management guideline.

Authors:
G Metan

J Mycol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address:

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December 2018

Prevalence of allergic bronchopulmonary aspergillosis in asthmatic patients: A prospective institutional study.

Indian J Tuberc 2018 Oct 13;65(4):285-289. Epub 2018 Apr 13.

Director, National Institute of Tuberculosis and Respiratory Diseases, Sri Aurobindo Marg, New Delhi 110030, India.

Background: Allergic bronchopulmonary aspergillosis (ABPA) is characterized by an allergic inflammatory response to colonization by Aspergillus species, most commonly Aspergillus fumigatus.

Aim: To study the prevalence of ABPA in asthmatic patients presenting to our institute.

Materials And Methods: All consecutive asthma patients attending our allergy clinic Out Patient Department (OPD) over a period of 20 months were tested with skin prick test (SPT) for Aspergillus antigens and those who were found positive were further evaluated for ABPA using Greenberger's criteria. Read More

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October 2018

Successful outcome of disseminated mucormycosis in a 3-year-old child suffering from acute leukaemia: the role of isavuconazole? A case report.

BMC Pharmacol Toxicol 2018 Dec 6;19(1):81. Epub 2018 Dec 6.

Laboratoire de Parasitologie Mycologie, CHU Lille, Univ. Lille, INSERM U995 - LIRIC - Lille Inflammation Research International Centre, F-59000, Lille, France.

Background: The use of isavuconazole is approved for the management of invasive aspergillosis and mucormycosis, only in adults, as no paediatric pharmacology studies have been reported to date. Very few paediatric cases have been published concerning the use of isavuconazole. Amphotericin B is the only antifungal agent recommended in paediatric mucormycosis, but adverse effects and especially nephrotoxicity, even with the liposomal formulation, could be problematic. Read More

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December 2018

Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in .

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

mitogen-activated protein kinases (MAPKs) are involved in maintaining the normal morphology of the cell wall and providing resistance against cell wall-damaging agents. Upon cell wall stress, cell wall-related sugars need to be synthesized from carbohydrate storage compounds. Here we show that this process is dependent on cAMP-dependent protein kinase A (PKA) activity and regulated by the high-osmolarity glycerol response (HOG) MAPKs SakA and MpkC. Read More

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December 2018

Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature.

Respir Med Case Rep 2019 24;26:59-62. Epub 2018 Nov 24.

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.

A 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific IgE and precipitating antibodies against sp., central bronchiectasis, and mucoid impaction. Read More

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November 2018

Innocuous "foot lump" in patient with diabetes mellitus: A manifestation of phaeohyphomycosis.

Foot (Edinb) 2018 Nov 28;38:4-7. Epub 2018 Nov 28.

Department of Endocrinology, PGIMER, Chandigarh, 160012, IndiaIndia.

Invasive mycotic infection presenting as "foot lump" in an immunocompetent patient is extremely rare. The case highlights the difficulty in diagnosis of fungal infections of foot including attempts to isolate the fungus and non-response to anti-fungal agents. A 64-year-old lady with T2DM for four years presented with painless, gradually progressive swelling over plantar aspect of left mid-foot for six months. Read More

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November 2018

Aspergillus fumigatus branching complexity in vitro: 2D images and dynamic modeling.

Comput Biol Med 2018 Nov 28;104:215-219. Epub 2018 Nov 28.

Institute of Microbiology and Immunology, Faculty of Medicine University of Belgrade, Serbia. Electronic address:

Background: Aspergillus fumigatus causes serious infections in humans, and its virulence correlates with hyphal growth, branching and formation of the filamentous mycelium. The filamentous mycelium is a complex structure inconvenient for quantity analysis. In this study, we monitored the branching of A. Read More

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November 2018

Invasive fungal disease in patients with systemic lupus erythematosus from Southern China: a retrospective study.

Lupus 2018 Dec 8:961203318817118. Epub 2018 Dec 8.

1 Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: To investigate the characteristics and associated factors of invasive fungal disease in patients with systemic lupus erythematosus from Southern China.

Methods: A retrospective study was performed. Demographic and clinical characteristics, laboratory data, and radiographic manifestations were recorded. Read More

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December 2018

Invasive Fungal Disease in Patients Undergoing Umbilical Cord Blood Transplantation after Myeloablative Conditioning Regimen.

Eur J Haematol 2018 Dec 1. Epub 2018 Dec 1.

Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Objective: Characteristics and risk factors (RFs) of invasive fungal disease (IFD) have been little studied in the setting of umbilical cord blood transplantation (UCBT).

Method: We retrospectively included 205 single-unit myeloablative UCBT recipients with a median follow-up of 64 months.

Results: Fifty-six episodes of IFD were observed in 48 patients (23%) at a median time of 123 days after stem cell infusion. Read More

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December 2018
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Chronic pulmonary aspergillosis following pulmonary embolism.

Med Mycol Case Rep 2019 Mar 9;23:20-22. Epub 2018 Nov 9.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, United Kingdom.

Chronic pulmonary aspergillosis (CPA) is predominantly found alongside cavitating or bullous lung diseases. Although pulmonary embolism may cause cavitation, an association with CPA has not been well described. We describe a case of CPA in a 79-year-old female following bilateral pulmonary emboli. Read More

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March 2019
1 Read

Current Status of Azole-resistant Aspergillus fumigatus Isolates in East Asia.

Authors:
Daisuke Hagiwara

Med Mycol J 2018 ;59(4):E71-E76

Faculty of Life and Environmental Sciences, University of Tsukuba.

Aspergillus fumigatus is a saprophytic fungus that is a major causative pathogen for aspergillosis. Only a few classes of antifungals are used for treating this life-threatening fungal infection. Azoles are the first-line drugs and are widely used for the management and prophylaxis of aspergillosis. Read More

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January 2018

Heterogeneity in Pathogenicity-related Properties and Stress Tolerance in Aspergillus fumigatus Clinical Isolates.

Med Mycol J 2018 ;59(4):E63-E70

Medical Mycology Research Center, Chiba University.

Stress responses and pathogenicity have been extensively studied in Aspergillus fumigatus, the main causative pathogen of life-threatening aspergillosis. The heterogeneity in this pathogen's biology has recently attracted increasing attention. In the present work, we used 16 clinically isolated strains to investigate several properties relevant to the pathogenicity of A. Read More

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January 2018
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[Obstructive tracheobronchitis due to Aspergillus fumigatus in an immunocompetent patient].

Rev Iberoam Micol 2018 Nov 29. Epub 2018 Nov 29.

Servicio de Microbiología, Hospital Universitario Puerta del Mar, Cádiz, España; Instituto de Investigación Biomédica de Cádiz (INiBICA), Cádiz, España.

Background: Aspergillus tracheobronchitis (ATB) is an uncommon type of invasive pulmonary aspergillosis in which fungal involvement is limited to the tracheobronchial tree. While the more severe forms, such as pseudomembranous and ulcerative ATB, occur almost exclusively in immunocompromised patients, the milder obstructive form may occur in patients without immune deficiency.

Case Report: The case of a 32 year-old man with no previous history of illness, who was evaluated for recurrent right lower lobe pneumonia, is presented. Read More

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November 2018
1 Read

Successful treatment of invasive pulmonary aspergillosis caused by Aspergillus felis, a cryptic species within the Aspergillus section Fumigati: A case report.

J Infect Chemother 2018 Nov 30. Epub 2018 Nov 30.

Department of Infection Control Science, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan; Research Center for Infectious Disease Sciences (RCIDS), Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. Electronic address:

Aspergillus species are a major cause of life-threatening infections in immunocompromised hosts, and the most common pathogen of invasive aspergillosis is Aspergillus fumigatus. Recently, the development of molecular identification has revealed cryptic Aspergillus species, and A. felis is one such species within the Aspergillus section Fumigati reported in 2013. Read More

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November 2018
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Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):725-730

Programa Pós-Graduação em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.

Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual's susceptibility to invasive aspergillosis. We investigated the pertinent literature to determine whether polymorphisms in the genes encoding toll-like receptors and dectin-1 increase the susceptibility to invasive aspergillosis. Read More

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July 2018
1 Read

Omalizumab as add-on therapy in patients with asthma and allergic bronchopulmonary aspergillosis.

J Bras Pneumol 2018 Sep-Oct;44(5):439-441

. Serviço de Imunologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil.

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December 2018
1 Read

Recurrence of allergic bronchopulmonary aspergillosis after adjunctive surgery for aspergilloma: a case report with long-term follow-up.

BMC Pulm Med 2018 Dec 4;18(1):185. Epub 2018 Dec 4.

Department of Pulmonary Medicine, Eiju General Hospital, 2-23-16 Higashi Ueno, Taito-ku, Tokyo, 110-8645, Japan.

Background: Coexistence of aspergilloma and allergic bronchopulmonary aspergillosis (ABPA) has rarely been reported. Although the treatment for ABPA includes administration of corticosteroids and antifungal agents, little is known about the treatment for coexisting aspergilloma and ABPA. Furthermore, the impact of surgical resection for aspergilloma on ABPA is not fully understood. Read More

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December 2018
1 Read

Allergic bronchopulmonary aspergillosis successfully treated with benralizumab.

J Allergy Clin Immunol Pract 2018 Dec 1. Epub 2018 Dec 1.

Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, 2-1-11 Yokoami, Sumida, Tokyo 130-8587, Japan. Electronic address:

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December 2018
1 Read

Epidemiology of invasive fungal infections in immunocompromised children; an Australian national 10-year review.

Pediatr Blood Cancer 2018 Dec 4:e27564. Epub 2018 Dec 4.

Lady Cilento Children's Hospital, Children's Health Queensland, South Brisbane, Australia.

Background: A thorough understanding of local and contemporary invasive fungal infection (IFI) epidemiology in immunocompromised children is required to provide a rationale for targeted prevention and treatment strategies.

Methods: Retrospective data over 10 years from four tertiary pediatric oncology and hematopoietic stem cell transplant (HSCT) units across Australia were analyzed to report demographic, clinical, and mycological characteristics of IFI episodes, and crude IFI prevalence in select oncology/HSCT groups. Kaplan-Meier survival analyses were used to calculate 180-day overall survival. Read More

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December 2018
2 Reads

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.

Nat Microbiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Invasive pulmonary aspergillosis causes substantial mortality in immunocompromised individuals. Recognition of Aspergillus fumigatus by the host immune system leads to activation of the inflammasome, which provides protection against infection. However, regulation of inflammasome activation at the molecular level is poorly understood. Read More

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December 2018
2 Reads

Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres.

BMJ Paediatr Open 2018 27;2(1):e000367. Epub 2018 Oct 27.

Institute of Applied Clinical Science, Keele University, Keele, UK.

Objectives: Chest CT is increasingly used to monitor disease progression in children with cystic fibrosis (CF) but there is no national guideline regarding its use. Our objective was to assess the indications for undertaking chest CT and the protocols used to obtain scans.

Design Setting And Participants: An electronic questionnaire was developed to assess clinicians views on chest CT in children with CF. Read More

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October 2018
5 Reads

Late onset Allergic Broncho-Pulmonary Aspergillosis (ABPA).

QJM 2018 Nov 28. Epub 2018 Nov 28.

Department of Respiratory Medicine, Tallaght Hospital.

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November 2018
1 Read

Fatal Case of Pulmonary Invasive Aspergillus after Heart Transplant with a Rapidly Progressive Course.

Int J Organ Transplant Med 2018 1;9(3):140-143. Epub 2018 Aug 1.

Department of Cardiovascular Surgery, Tehran University of Medical Sciences, Tehran, Iran.

The incidence of invasive fungal infections is lower than that of bacterial infections in heart transplant recipients. However, they are always life-threatening. Clinical manifestations may range from asymptomatic colonization to disseminated infection. Read More

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August 2018
1 Read

Siroheme Is Essential for Assimilation of Nitrate and Sulfate as Well as Detoxification of Nitric Oxide but Dispensable for Murine Virulence of .

Front Microbiol 2018 12;9:2615. Epub 2018 Nov 12.

Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.

The saprophytic mold is the most common airborne fungal pathogen causing severe invasive fungal infections in immunocompromised patients. Siroheme is a heme-like prosthetic group used by plants and microorganisms for sulfate and nitrate assimilation but is absent in higher eukaryotes. Here, we investigated the role of siroheme in by deletion of the gene encoding the bifunctional dehydrogenase/ferrochelatase enzyme Met8. Read More

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November 2018
1 Read

[Successful treatment of two cases of decompensated liver cirrhosis underlying with pulmonary aspergillosis infection].

Zhonghua Gan Zang Bing Za Zhi 2018 Sep;26(9):700-701

Cangzhou Central Hospital, Cangzhou Hebei 061000, China.

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September 2018
1 Read

Reduction in Mortality after Umbilical Cord Blood Transplantation in Children over a 20-Year Period (1995-2014).

Biol Blood Marrow Transplant 2018 Nov 24. Epub 2018 Nov 24.

Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC. Electronic address:

Background: Infections and graft-versus-host disease have historically resulted in high mortality among children undergoing umbilical cord blood transplantation (UCBT). However, recent advances in clinical practice have likely improved outcomes of these patients.

Methods: We conducted a retrospective cohort study of children (<18 years of age) undergoing UCBT at Duke University between January 1, 1995 and December 31, 2014. Read More

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November 2018
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Utility of serum galactomannan antigen testing combined with chest computed tomography for early diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies with febrile neutropenia after antifungal drug treatment.

J Int Med Res 2018 Nov 26:300060518811472. Epub 2018 Nov 26.

Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.

Objective: To investigate the value of serum galactomannan antigen (GM) testing combined with chest computed tomography (CT) as a noninvasive method for early diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematological malignancies with febrile neutropenia after antifungal drug treatment.

Methods: We retrospectively analyzed the data of 376 patients with febrile neutropenia from January 2015 to August 2017. All patients were given broad-spectrum antibiotics and divided into the control group (effective antibiotic treatment, no antifungal drugs given) and the observational group (ineffective antibiotic treatment, antifungal drugs given). Read More

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November 2018
1 Read

Variability and exposure-response relationships of isavuconazole plasma concentrations in the Phase 3 SECURE trial of patients with invasive mould diseases.

J Antimicrob Chemother 2018 Nov 21. Epub 2018 Nov 21.

Department of Paediatric Haematology/Oncology, University Children's Hospital Münster, Münster, Germany.

Objectives: This analysis evaluated the variability of isavuconazole plasma concentrations between subjects and between sampling times, and assessed their relationship to outcomes for subjects with invasive fungal disease (IFD) in the SECURE trial.

Methods: Isavuconazole-treated subjects received 372 mg of isavuconazonium sulphate (corresponding to 200 mg of isavuconazole) three times daily for 2 days, then once daily. Plasma samples were collected after day 4 and analysis sets were constructed as follows: analysis set 1 included all samples from subjects with proven/probable/possible IFD who received ≥1 dose of isavuconazole; analysis set 2 included samples from subjects in analysis set 1 who had provided >1 sample; and analysis set 3 included samples from subjects in analysis set 1 with proven/probable invasive aspergillosis. Read More

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November 2018
2 Reads

HISTOPATHOLOGIC FINDINGS IN FREE-RANGING CALIFORNIA HUMMINGBIRDS, 1996-2017.

J Wildl Dis 2018 Nov 26. Epub 2018 Nov 26.

1   Veterinary Diagnostic Laboratory, College of Veterinary Medicine, 4125 Beaumont Road, Michigan State University, Lansing, Michigan 48910, USA.

A histopathologic study of free-ranging hummingbirds in California was performed to identify mortality trends. Tissues from 61 wild hummingbirds representing five native California species collected by the San Diego Zoo from 1996 to 2016 or the Lindsay Wildlife Experience from 2015 to 2017 were histologically examined. Birds were either found dead or moribund at the time of submission or were euthanized due to unresolvable health issues. Read More

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November 2018
4 Reads

Coinfection of pneumocystis jiroveci pneumonia and pulmonary aspergillosis in a non-HIV-infected patient.

J Microbiol Immunol Infect 2018 Dec 12;51(6):860-861. Epub 2018 Nov 12.

Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; College of Human Science and Social Innovation, Hungkuang University, Taichung, 43302, Taiwan; School of Chinese Medicine, China Medical University, Taichung, 40447, Taiwan. Electronic address:

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December 2018
1 Read

[Microbiological diagnosis of invasive mycosis].

Rev Iberoam Micol 2018 Nov 21. Epub 2018 Nov 21.

Servicio de Microbiología, Hospital Universitari i Politècnic La Fe, Valencia, España. Electronic address:

The prognosis of invasive fungal infections (IFI) depends on the speed of diagnosis and treatment. Conventional diagnostic methods are of low sensitivity, laborious and too slow, leading to the need for new, faster, and more efficient diagnostic strategies. There are several techniques for diagnosing a candidemia that are faster than the conventional blood culture (BC). Read More

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November 2018
1 Read

Comparison of Skin Cancer Incidence in Caucasian and Non-Caucasian Liver Vs. Lung Transplant Recipients: A Tale of Two Regimens.

Clin Drug Investig 2018 Nov 23. Epub 2018 Nov 23.

Department of Dermatology, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.

Background: Organ transplantation is a significant risk factor for the development of skin cancer. The impact of skin type, immunosuppressive regimens, and photosensitizing agents requires further study.

Objective: The objective of this study was to compare skin cancer development between Caucasian and non-Caucasian transplant recipients at the University of Southern California. Read More

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November 2018
16 Reads

[Invasive aspergillosis in solid organ transplantation].

Rev Iberoam Micol 2018 Nov 19. Epub 2018 Nov 19.

Unidad de Enfermedades Infecciosas, Instituto de Investigación Hospital Universitario 12 de Octubre (i+12), Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, España. Electronic address:

Solid organ transplant (SOT) recipients have a high risk for developing invasive fungal infections (IFI). Treatment is difficult due to the interaction between the antifungal and immunosuppressant drugs, as well as the risk of hepatotoxicity and kidney failure associated with voriconazole and amphotericinB, respectively. Isavuconazole is a new antifungal triazole agent with excellent oral bioavailability, predictable and linear pharmacokinetics, good tolerance and low adverse effects. Read More

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November 2018
2 Reads

[Epidemiology of invasive mycoses: A landscape in continuous change].

Rev Iberoam Micol 2018 Nov 19. Epub 2018 Nov 19.

Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Bilbao, España. Electronic address:

The landscape of invasive mycoses is in a continuous evolution with important implications for their diagnosis and treatment. The overall burden remains high, particularly in neonates and the elderly, patients admitted to intensive care units, using prostheses, catheters or other intravenous devices, those receiving different immunosuppressant treatments or antineoplastic chemotherapy, or transplant recipients. In addition, opportunistic mycoses can be associated with HIV infection. Read More

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November 2018
2 Reads

In silico protein interaction network analysis of virulence proteins associated with invasive aspergillosis for drug discovery.

Curr Top Med Chem 2018 Nov 20. Epub 2018 Nov 20.

Centre for Biotechnology, Maharshi Dayanand University, Rohtak-124001, Haryana. India.

Protein-Protein interaction (PPI) network analysis of virulence proteins of Aspergillus fumigatus is prevailing strategy to understand the mechanism behind the virulence of A. fumigatus. The identification of major hub proteins and targeting the hub protein as a new antifungal drug target will help in treating the invasive aspergillosis. Read More

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November 2018
1 Read

Preparations for Invasion: Modulation of Host Lung Immunity During Pulmonary by Gliotoxin and Other Fungal Secondary Metabolites.

Front Immunol 2018 6;9:2549. Epub 2018 Nov 6.

Instituto de Carboquímica ICB-CSIC, Zaragoza, Spain.

Pulmonary aspergillosis is a severe infectious disease caused by some members of the genus, that affects immunocompetent as well as immunocompromised patients. Among the different disease forms, Invasive Aspergillosis is the one causing the highest mortality, mainly, although not exclusively, affecting neutropenic patients. This genus is very well known by humans, since different sectors like pharmaceutical or food industry have taken advantage of the biological activity of some molecules synthetized by the fungus, known as secondary metabolites, including statins, antibiotics, fermentative compounds or colorants among others. Read More

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November 2018
4 Reads

Isavuconazole: Case Report and Pharmacokinetic Considerations.

Chemotherapy 2018 11 20;63(5):253-256. Epub 2018 Nov 20.

Clinical Pharmacology Unit, University Hospital Campus Bio-Medico of Rome, Rome,

Invasive fungal disease (IFD) is one of the major causes of morbidity and mortality in immunocompromised patients. Voriconazole (VCZ) and posaconazole (PCZ) remain the most widely used antifungals for the prophylaxis and treatment of IFD. However, VCZ and PCZ are liable for drug-drug interactions and show a pharmacokinetic variability that requires therapeutic drug monitoring (TDM). Read More

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November 2018
5 Reads

[Chronic granulomatous disease: multiple infections as clinical presentation. Pediatric case report].

Arch Argent Pediatr 2018 Dec;116(6):e744-e748

Servicio de Infectología, Hospital de Niños Sor María Ludovica.

Chronic granulomatous disease is an uncommon primary immunodeficiency due to a defect of the killing activity of phagocytes, caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system. The incidence is 1 in 250 000 live births. It can occur from infancy to adulthood, usually in children under 2 years. Read More

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December 2018
1 Read

Long term survival of a dog with disseminated infection without definitive treatment.

Med Mycol Case Rep 2018 Dec 10;22:1-3. Epub 2018 Jul 10.

Sydney School of Veterinary Science, Faculty of Science, Evelyn Williams Building B10, University of Sydney, NSW 2006, Australia.

Canine disseminated fungal infection by species carries a guarded to grave prognosis as they often rapidly progress and are refractory to treatment with many euthanased soon after diagnosis. This case report describes a 2.5 year old female spayed German Shepherd Dog diagnosed with disseminated infection for which definitive treatment was declined by the owners. Read More

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December 2018
1 Read

Role of Downregulation and Phosphorylation of Cofilin in Polarized Growth, MpkA Activation and Stress Response of .

Front Microbiol 2018 2;9:2667. Epub 2018 Nov 2.

Institute for Disease Control and Prevention of PLA, Beijing, China.

causes most of aspergillosis in clinic and comprehensive function analysis of its key protein would promote anti-aspergillosis. In a previous study, we speculated actin depolymerizing factor cofilin might be essential for viability and found its overexpression upregulated oxidative response and cell wall polysaccharide synthesis of this pathogen. Here, we constructed a conditional mutant to determine the essential role of cofilin. Read More

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November 2018
4 Reads

Impact of Antifungal Compounds on Viability and Anti- Activity of Human Natural Killer Cells.

Antimicrob Agents Chemother 2018 Nov 19. Epub 2018 Nov 19.

Divisions of Pediatric Hematology and Oncology and Pediatric Pulmonology, Allergology and Cystic Fibrosis, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, Frankfurt, Germany

Despite the availability of new antifungal compounds, invasive aspergillosis carries high morbidity and mortality in hematopoietic stem cell transplant recipients. studies and animal models suggest that the adoptive transfer of Natural Killer (NK) cells could be a promising immunotherapeutic option in this setting. As it is unclear whether viability and function of human NK cells are affected by common antifungal agents, we analyzed the interaction of various concentrations of amphotericin B-deoxycholate (AmB-D), liposomal amphotericin B, caspofungin, fluconazole, voriconazole, and posaconazole with human NK cells. Read More

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November 2018
4 Reads

APX001 is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis.

Antimicrob Agents Chemother 2018 Nov 19. Epub 2018 Nov 19.

Division of Infectious Diseases, Los Angeles Biomedical Resseach Institute at Harbor-Uinversity of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA

Invasive pulmonary aspergillosis (IPA) due to is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high and new treatments are needed. The novel antifungal APX001A targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidyl inositol (GPI)-anchored mannoproteins in fungi. Read More

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November 2018
17 Reads
4.476 Impact Factor

[Current therapeutic options in invasive mycosis and potential therapeutic role of isavuconazole].

Rev Iberoam Micol 2018 Nov 16. Epub 2018 Nov 16.

Servicio de Enfermedades Infecciosas, Hospital Clínic de Barcelona-IDIBAPS; Universitat de Barcelona, FungiCLINIC Research group (AGAUR), Barcelona, España. Electronic address:

The treatment of invasive fungal infections has deeply evolved in recent years with the inclusion of new antifungals to the therapeutic treatment arsenal. A new azole, isavuconazole, has been recently approved. This review focuses on the role of isavuconazole for treating the most important invasive fungal infections: invasive candidiasis, aspergillosis, mucormicosis, infections caused by other filamentous fungi and those caused by dimorphic fungi. Read More

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November 2018
1 Read

Invasive fungal infection by in immunocompetent hosts: A case series and literature review.

Med Mycol Case Rep 2019 Mar 25;23:12-15. Epub 2018 Oct 25.

Clinical Research Center, Fundación Valle del Lili, Carrera 98 #18-49, Cali, Colombia.

Invasive aspergillosis usually affects immunocompromised hosts with variable manifestations depending on the site of infection. In this article, we present two cases of invasive Aspergillosis in two non-immunocompromised patients; both cases had a paranasal sinuses infection, with intraorbital and intracranial extension, requiring surgery and antifungal treatment with Voriconazole. These cases were initially diagnosed as paranasal sinus neoplasms. Read More

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March 2019
1 Read

Integrating anatomo-physiological changes and pharmacogenomics in anti-infective therapy management: is it a major concern?

Br J Clin Pharmacol 2018 Nov 16. Epub 2018 Nov 16.

Pôle Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, F-38000, Grenoble, France.

Success of anti-infective therapy is a major challenge in some patients given anatomo-physiological changes and genetic variations. In this case anecdote, we report the management strategy of a patient suffering from chronic pulmonary aspergillosis in a context of anorexia nervosa and genetic polymorphism. Read More

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November 2018
2 Reads