18,621 results match your criteria Aspergillosis


Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".

Science 2018 Jun;360(6395)

Institute of Microbiology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic.

Shlezinger (Reports, 8 September 2017, p. 1037) report that the common fungus , a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin. Read More

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Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis.

Oncotarget 2018 Jun 1;9(42):26724-26736. Epub 2018 Jun 1.

Department of Hematology and Cell Therapy, University Hospital, F-33000 Bordeaux, France.

Posaconazole prophylaxis has demonstrated efficacy in the prevention of invasive aspergillosis during prolonged neutropenia following acute myeloid leukemia induction chemotherapy. Antifungal treatment decreases serum galactomannan enzyme immunoassay diagnostic accuracy that could delay the diagnosis and treatment. We retrospectively studied patients with acute myeloid leukemia who underwent intensive chemotherapy and antifungal prophylaxis by posaconazole oral suspension. Read More

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Utility of recombinant Aspergillus fumigatus antigens in the diagnosis of allergic bronchopulmonary aspergillosis: a systematic review and diagnostic test accuracy meta-analysis.

Clin Exp Allergy 2018 Jun 21. Epub 2018 Jun 21.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: The role of recombinant A.fumigatus (rAsp) antigens in the diagnosis of allergic bronchopulmonary aspergillosis (ABPA) has not been systematically evaluated. Herein, we evaluate the utility of recombinant A. Read More

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June 2018
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Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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Invasive Aspergillosis Mimicking Metastatic Lung Cancer.

Front Oncol 2018 5;8:188. Epub 2018 Jun 5.

Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, Netherlands.

In a patient with a medical history of cancer, the most probable diagnosis of an FDG-avid pulmonary mass combined with intracranial abnormalities on brain imaging is metastasized cancer. However, sometimes a differential diagnosis with an infectious cause such as aspergillosis can be very challenging as both cancer and infection are sometimes difficult to distinguish. Pulmonary aspergillosis can present as an infectious pseudotumour with clinical and imaging characteristics mimicking lung cancer. Read More

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Causes of mortality and morbidity in free-ranging mustelids in Switzerland: necropsy data from over 50 years of general health surveillance.

BMC Vet Res 2018 Jun 19;14(1):195. Epub 2018 Jun 19.

Centre for Fish and Wildlife Health (FIWI), Vetsuisse Faculty, University of Bern, Länggassstrasse 122, Postfach, 3001, Bern, Switzerland.

Background: Although mustelids occur worldwide and include a wide range of species, little is known about the diseases affecting them. Mustelids have regularly been submitted for post mortem investigation in the framework of the program for general wildlife health surveillance in Switzerland, which has been in place for nearly 60 years. We performed a retrospective analysis of the necropsy reports on mustelids submitted to the diagnostic service of the University of Bern. Read More

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Diagnostic cut-off of A.fumigatus-specific IgG in the diagnosis of chronic pulmonary aspergillosis.

Mycoses 2018 Jun 19. Epub 2018 Jun 19.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

A.fumigatus-specific IgG is pivotal in making the diagnosis of chronic pulmonary aspergillosis (CPA). However, the cut-off value for A. Read More

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June 2018
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Economic impact of treating invasive mold disease with isavuconazole compared with liposomal amphotericin B in the UK.

Future Microbiol 2018 06 18. Epub 2018 Jun 18.

Basilea Pharmaceutica International Ltd, Basel, Switzerland.

Aim: Invasive mold diseases (IMDs) are associated with significant morbidity and mortality. Approved treatments include voriconazole (VORI), liposomal amphotericin B (L-AMB), posaconazole (POSA) and isavuconazole (ISAV). A UK-based economic model was developed to explore the cost of treating IMDs with ISAV versus L-AMB followed by POSA. Read More

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Improved and adopted murine models to combat pulmonary aspergillosis.

Authors:
Gaspar Banfalvi

Appl Microbiol Biotechnol 2018 Jun 17. Epub 2018 Jun 17.

Department of Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, 1 Egyetem Street, Debrecen, H-4002, Hungary.

The insufficient basic and clinical knowledge about invasive mold infections necessitated to review aspergillosis rodent models. The scope of this review has two major aspects. (1) It briefly summarizes Aspergillus toxicoses, the adverse effects of Aspergillus mycotoxins, the virulence factors of Aspergillus fumigatus, and how mild Aspergillus infections can turn to immunosuppressive diseases, ultimately to lethal invasive pulmonary aspergillosis. Read More

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Biosynthesis of Low Molecular Weight Antifungal Protein from Aspergillus giganteus in Batch Fermentation and In-Vitro Assay.

Biocontrol Sci 2018 ;23(2):41-51

School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi (Banaras Hindu University).

 In present study, Taguchi's design of experiment L orthogonal array was created using Qualitek-4 software with four most critical factors namely, KHPO, MgSO, CaCl and culture pH. Production of a new intracellular antifungal protein in submerged fermentation was optimized with yield of 0.98±0. Read More

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January 2018
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Assessment of posaconazole salvage therapy in chronic pulmonary aspergillosis by using predefined response criteria.

Int J Antimicrob Agents 2018 Jun 12. Epub 2018 Jun 12.

The National Aspergillosis Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

Objective: Chronic pulmonary aspergillosis (CPA) is a progressive infection that destroys lung tissue in non-immunocompromised patients. First line therapies for CPA (itraconazole and/or voriconazole) are often curtailed due to toxicity or the development of drug resistance. Posaconazole is a potential alternative for these patients. Read More

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Pulmonary Nodular Lymphoid Hyperplasia with Mass-Formation: Clinicopathologic Characteristics of Nine Cases and Review of the Literature.

J Pathol Transl Med 2018 Jun 15. Epub 2018 Jun 15.

Department of Pathology and Translational Genomics, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Pulmonary nodular lymphoid hyperplasia (PNLH) is a non-neoplastic pulmonary lymphoid disorder that can be mistaken for malignancy on radiography. Herein, we present nine cases of PNLH, emphasizing clinicoradiological findings and histological features.

Materials And Methods: We analyzed radiological and clinicopathological features from the electronic medical records of nine patients (eight females and one male) diagnosed with PNLH. Read More

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"Fleeting pulmonary infiltrates in allergic bronchopulmonary aspergillosis" Misdiagnosed as tuberculosis.

Int J Mycobacteriol 2018 Apr-Jun;7(2):186-190

Department of Internal Medicine, MIMSR Medical College, Latur, Maharashtra, India.

Allergic bronchopulmonary aspergillosis (ABPA) is underdiagnosed and underevaluated routinely because of clinical and radiological overlap with tuberculosis (TB), especially in tropical setting with high TB burden countries like India. ABPA is the best-recognized manifestation of Aspergillus-associated hypersensitivity to Aspergillus antigens in patients with long-standing atopic asthma. ABPA with varied clinical presentation has been reported to occur in 20% of asthmatic patients admitted to hospitals and in 5% of all rhinitis cases. Read More

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June 2018
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Recent advances in understanding and managing infectious diseases in solid organ transplant recipients.

F1000Res 2018 24;7. Epub 2018 May 24.

Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Paris Descartes University, IHU Imagine, Paris, France.

Undergoing solid organ transplantation (SOT) exposes the recipient to various infectious risks, including possible transmission of pathogen by the transplanted organ, post-surgical infections, reactivation of latent pathogens, or novel infections. In the last few years, the emergence of Zika virus has raised concerns in the transplant community. Few cases have been described in SOT patients, and these were associated mainly with moderate disease and favorable outcome; the notable exception is a recent case of fatal meningo-encephalopathy in a heart transplant recipient. Read More

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Galactomannan antigenemia as a biomarker for therapeutic response of invasive aspergillosis: implications for clinical trial design and patient care.

Expert Rev Mol Diagn 2018 Jun 20:1-4. Epub 2018 Jun 20.

b Weill Cornell Medical College, Transplantation-Oncology Infectious Diseases Program , Weill Cornell Medical College/New York-Presbyterian Hospital , New York , NY , USA.

Introduction: Clinical trials for invasive pulmonary aspergillosis, a potentially lethal mold infection, are complex investigations that require protracted time and extensive resources, delaying the development of new antifungal agents for this important disease. Areas covered: In this paper, the authors examine a novel approach to study invasive pulmonary aspergillosis in humans, with a focus on the potentials and pitfalls of surrogate end points such as galactomannan antigenemia to evaluate therapeutic response to novel compounds. Expert commentary: The authors believe the use of serum galactomannan as a primary end point in clinical trials may allow for development studies that could be accomplished with fewer resources. Read More

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June 2018
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Diagnosis of invasive mold diseases in patients with haematological malignancies using Aspergillus, Mucorales and panfungal PCR in BAL.

Transpl Infect Dis 2018 Jun 13:e12953. Epub 2018 Jun 13.

Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital Basel, Petersgraben 4, CH, 4031, Basel, Switzerland.

Background: Accurate diagnosis of invasive mold diseases (IMD) remains challenging. Here, the performance of panfungal PCR, Aspergillus and Mucorales PCR in bronchoalveolar lavage (BAL) was evaluated.

Methods: We conducted a single-center study including 167 hematologic patients at risk for IMD with BAL performed 2011-2014. Read More

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Molecular Insights Into Development and Virulence Determinants of : A Proteomic Perspective.

Front Cell Infect Microbiol 2018 29;8:180. Epub 2018 May 29.

Amity Institute of Biotechnology, Amity University, Noida, India.

species are the major cause of health concern worldwide in immunocompromised individuals. Opportunistic cause invasive to allergic aspergillosis, whereas non-infectious have contributed to understand the biology of eukaryotic organisms and serve as a model organism. Morphotypes of such as conidia or mycelia/hyphae helped them to survive in favorable or unfavorable environmental conditions. Read More

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"Emergence of azole resistant from immunocompromised hosts in India".

Antimicrob Agents Chemother 2018 Jun 11. Epub 2018 Jun 11.

Rachna Seth, MD, Department of Paediatrics, All India Institute of Medical Sciences, New Delhi, India.

This prospective study shows that the rate of azole resistant (ARAF) in Indian immunocompromised patient population with invasive aspergillosis (IA) is low, 6/706 (0.8%). This lower rate supports the continued use of voriconazole as the first line of treatment. Read More

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Sputum signatures for invasive pulmonary aspergillosis in patients with underlying respiratory diseases (SPARED): study protocol for a prospective diagnostic trial.

BMC Infect Dis 2018 Jun 11;18(1):271. Epub 2018 Jun 11.

Respiratory Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.

Background: Invasive pulmonary aspergillosis (IPA) has been increasingly reported in patients with underlying respiratory diseases (URD). Early diagnosis of IPA is crucial for mortality reduction and improved prognosis, yet remains difficult. Existing diagnostic tools for IPA largely rely on the detection of biomarkers based on serum or bronchoalveolar lavage fluid (BALF), both of which have their limitations. Read More

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June 2018
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Pulmonary infectious complications after hematopoietic stem cell transplantation: a practical guide to clinicians.

Curr Opin Organ Transplant 2018 Jun 7. Epub 2018 Jun 7.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic Arizona, Phoenix, Arizona, USA.

Purpose Of Review: The current review highlights the most relevant articles on lung infections following hematopoietic stem cell transplantation (HCT) published over the last year. Between 30 and 50% of HCT recipients will develop pulmonary infiltrates. These pulmonary complications may be infectious (caused by virus, bacteria, fungi, or protozoa) or noninfectious (e. Read More

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June 2018
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Epidemiology and risk factors for invasive fungal infections during induction chemotherapy for newly diagnosed acute myeloid leukemia: A retrospective cohort study.

PLoS One 2018 8;13(6):e0197851. Epub 2018 Jun 8.

Division of Infection Disease, Department of Internal Medicine, China Medical University Hospital, Taichung City, Taiwan, R.O.C.

This study investigated the epidemiology and risk factors associated with invasive fungal infections (IFIs) during induction chemotherapy in a cohort of Taiwanese patients with newly-diagnosed acute myeloid leukemia (AML). IFIs are a significant complication in the management of immunocompromised cancer patients; such infections are associated with a high incidence of morbidity and mortality, particularly in many South-Asian countries, where IFI rates are increasing. We retrospectively analyzed IFI incidence data from 105 patients with newly diagnosed AML at a single center undergoing their first course of induction chemotherapy without primary antifungal prophylaxis between November 2008 and December 2014. Read More

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Estimated Burden of Serious Fungal Infections in Malawi.

J Fungi (Basel) 2018 May 21;4(2). Epub 2018 May 21.

National Aspergillosis Centre, Wythenshawe Hospital and The University of Manchester, Manchester M13 9PL, UK.

Despite efforts to address the burden of fungal infections in Malawi, the prevalence and incidence remain largely unknown. We assessed the annual burden in the general population and among populations at high risk and fungal infection frequencies in each particular population to estimate the national incidence or prevalence. The Malawi population is approximately 17. Read More

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IMMUNOLOGICAL COROLLARY OF THE PULMONARY MYCOBIOME IN BRONCHIECTASIS: THE CAMEB STUDY.

Eur Respir J 2018 Jun 7. Epub 2018 Jun 7.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

Understanding the composition and clinical importance of the fungal mycobiome was recently identified as a key topic in a "research priorities" consensus statement for bronchiectasis Patients were recruited as part of the CAMEB study: an international multicentre cross-sectional ohort of sian and atched uropean ronchiectasis patients. The mycobiome was determined in 238 patients by targeted amplicon shotgun sequencing of the 18S-28S rRNA internally transcribed spacer regions ITS1 and ITS2. Specific qPCR for detection of and conidial quantification for a range of airway species was performed. Read More

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A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model.

J Transl Med 2018 Jun 7;16(1):157. Epub 2018 Jun 7.

Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Background: Invasive pulmonary aspergillosis (IPA) is a life-threatening disease in immunosuppressed patients. Voriconazole is commonly used to prevent and treat IPA in the clinic, but the optimal prophylactic antifungal regimen is unknown. The objective of this study was to clarify the mechanism underlying how voriconazole prevents IPA based on a target cellular pharmacokinetics/pharmacodynamics model, with the aim of identifying a way to design an optimal prophylactic antifungal regimen. Read More

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June 2018
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National Jewish Health Classical Pulmonary Radiology Case Reports: Imaging Features of Allergic Bronchopulmonary Aspergillosis.

QJM 2018 Jun 6. Epub 2018 Jun 6.

National Jewish Health, Department of Radiology, Denver, CO 80206.

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Invasive Pulmonary Aspergillosis in the Epidural Space in a Patient with Acute Myelogenous Leukemia with Myelodysplasia-related Changes: A Case Study and Literature Review of Vertebral Aspergillosis in Japan.

Intern Med 2018 Jun 6. Epub 2018 Jun 6.

Division of Hematology, Shonan Kamakura General Hospital, Japan.

Vertebral aspergillosis is a rare infectious disease with a high mortality rate. We herein report a 70-year-old woman with acute myelogenous leukemia with myelodysplasia-related changes, nontuberculous mycobacteriosis, and bronchiectasis who presented with a fever and cough. Her clinical symptoms and laboratory test results suggested febrile neutropenia and pneumonia. Read More

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June 2018
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Aspergillus Sternomyelitis Developed from Chronic Pulmonary Aspergillosis as a Late Complication to Lobectomy for Lung Cancer.

Intern Med 2018 Jun 6. Epub 2018 Jun 6.

Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan.

Progressive fibrobullous changes in the residual lobes are sometimes observed after lobectomy. Aspergillus osteomyelitis is an uncommon infection that rarely occurs sternally. A 70-year-old man who had undergone lobectomy 12 years earlier was admitted to our hospital for chest pain. Read More

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June 2018
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QPCR detection of Mucorales DNA in bronchoalveolar lavage fluid to diagnose pulmonary mucormycosis.

J Clin Microbiol 2018 Jun 6. Epub 2018 Jun 6.

Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, Besançon, France

Early diagnosis and treatment are essential to improving the outcome of mucormycosis. The aim of this retrospective study was to assess the contribution of quantitative PCR detection of Mucorales DNA in bronchoalveolar lavage fluids for early diagnosis of pulmonary mucormycosis.Bronchoalveolar lavage fluids (n=450) from 374 patients with pneumonia and immunosuppressive conditions were analyzed using a combination of 3 quantitative PCR assays targeting the main genera involved in mucormycosis in France (). Read More

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June 2018
2 Reads

Invasive pulmonary aspergillosis secondary to microwave ablation: a multicenter retrospective study.

Int J Hyperthermia 2018 Jun 6:1-8. Epub 2018 Jun 6.

a Department of Oncology , Shandong Provincial Hospital Affiliated to Shandong University , Jinan, Shandong Province , China.

Purpose: Invasive pulmonary aspergillosis (IPA) is a life-threatening complication of microwave ablation (MWA) during the treatment of primary or metastatic lung tumors. The purpose of this study was to investigate the clinical, radiological and demographic characteristics and treatment responses of patients with IPA after MWA.

Materials And Methods: From January 2011 to January 2016, all patients who were treated by MWA of their lung tumors from six health institutions were enrolled in this study. Read More

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June 2018
2 Reads

A vexing case of bone pain in a renal transplant recipient: Voriconazole-induced periostitis.

Transpl Infect Dis 2018 Jun 5:e12941. Epub 2018 Jun 5.

Transplant Program, Department of Nephrology, St. Paul's Hospital, Providence Healthcare, Vancouver, BC, Canada.

Immunosuppression increases the risk of opportunistic infections including fungal infections in solid organ transplant recipients. Voriconazole is used to treat invasive aspergillus infections but prolonged usage may rarely lead to periostitis. Increased plasma fluoride concentration leading to osteoblastic upregulation is thought to be the catalyst, and symptom reversal occurs with discontinuation of the offending agent. Read More

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June 2018
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Primary fungal prophylaxis in hematological malignancy: A network meta-analysis of randomized controlled trials.

Antimicrob Agents Chemother 2018 Jun 4. Epub 2018 Jun 4.

Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

Several new anti-fungal agents have become available for primary fungal prophylaxis of neutropenia fever in haematological malignancy patients. Our aim was to synthesize all evidence on efficacy and enable an integrated comparison of all current treatments.We performed a systematic literature review to identify all publicly available evidence from randomized controlled trials (RCT). Read More

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June 2018
2 Reads

Infectious complications in adults undergoing intensive chemotherapy for acute myeloid leukemia in 2001-2005 using the Japan Adult Leukemia Study Group AML201 protocols.

Support Care Cancer 2018 Jun 2. Epub 2018 Jun 2.

Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Purpose: The Japan Adult Leukemia Study Group (JALSG) AML201 protocols are regimens for remission induction and consolidation chemotherapy of acute myeloid leukemia (AML) and have been widely accepted in Japan since 2001. Management of infectious complications during chemotherapy has a key role in the supportive care of AML patients.

Methods: By using case report forms collected in December 2001 and December 2005, we retrospectively analyzed the infectious complications in adult patients treated by using the JALSG AML201 protocols against AML (excluding promyelocytic leukemia). Read More

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June 2018
2 Reads

TR34/L98H Mutation in CYP51A Gene in Aspergillus fumigatus Clinical Isolates During Posaconazole Prophylaxis: First Case in Korea.

Mycopathologia 2018 Jun 1. Epub 2018 Jun 1.

Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Azole resistance in Aspergillus fumigatus is an emerging problem, especially in immunocompromised patients. It has been reported worldwide, including in Asia, but has not yet been reported in Korea. Here, we report a case of invasive pulmonary aspergillosis (IPA) caused by azole-resistant A. Read More

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June 2018
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Central Nervous System Aspergillosis: An Unexpected Complication following Neurosurgery.

Diseases 2018 May 31;6(2). Epub 2018 May 31.

Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Post-surgical aspergillosis is an uncommon complication that carries a high mortality rate in affected patients. The diagnosis is challenging given the lack of highly sensitive methods to isolate from surgical sites. Here, we present a case of post-surgical aspergillosis that occurred after the resection of acoustic neuroma in an immunocompetent patient. Read More

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Cytomorphological Diagnosis of Isolated Cutaneous Aspergillosis in an Immunocompetent Host.

Indian Dermatol Online J 2018 May-Jun;9(3):206-208

Department of Pathology, PGIMER, Dr. RML Hospital, New Delhi, India.

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Issues in the management of invasive pulmonary aspergillosis in non-neutropenic patients in the intensive care unit: A role for isavuconazole.

IDCases 2018 1;12:7-9. Epub 2018 Mar 1.

Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria Misericordia University Hospital, Udine, Italy.

Background: Almost half of all cases of invasive aspergillosis (IA) occur in the intensive care unit (ICU), with mortality rates of 70-80% for probable or proven cases. IA has become a major concern among non-neutropenic patients in the ICU with chronic obstructive pulmonary disease (COPD) but although prompt, appropriate antifungal therapy is crucial, diagnosis in this situation is challenging. Criteria for a probable diagnosis in critically ill patients have been proposed to help to expedite therapy. Read More

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March 2018
2 Reads

Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis.

Nat Microbiol 2018 May 30. Epub 2018 May 30.

Department of Medicine, University of Crete, Heraklion, Crete, Greece.

LC3-associated phagocytosis (LAP) is a non-canonical autophagy pathway regulated by Rubicon, with an emerging role in immune homeostasis and antifungal host defence. Aspergillus cell wall melanin protects conidia (spores) from killing by phagocytes and promotes pathogenicity through blocking nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent activation of LAP. However, the signalling regulating LAP upstream of Rubicon and the mechanism of melanin-induced inhibition of this pathway remain incompletely understood. Read More

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May 2018
4 Reads

[Investigation of Virulence Factors by "Omics" Approaches].

Med Mycol J 2018 ;59(2):J35-J40

Medical Mycology Research Center, Chiba University.

 Aspergillus fumigatus is the predominant fungal pathogen responsible for life-threatening systemic infections in humans. Recently developed high-throughput whole genome sequencing (WGS) and RNA-Seq technologies have proven to be powerful tools for systematically investigating pathogenic organisms. In this review, we present new virulence factors obtained through our "omics" researches on A. Read More

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January 2018

Role of FKS Gene in the Susceptibility of Pathogenic Fungi to Echinocandins.

Med Mycol J 2018 ;59(2):E31-E40

Department of Surgical Pathology, Toho University School of Medicine.

Echinocandins are antifungal agents that specifically inhibit the biosynthesis of 1,3-β-D-glucan, a major structural component of fungal cell walls. Echinocandins are recommended as first-line or alternative/salvage therapy for candidiasis and aspergillosis in antifungal guidelines of various countries. Resistance to echinocandins has been reported in recent years. Read More

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January 2018

Local retrospective analysis of galactomannan cut-off values in bronchoalveolar lavage fluids for diagnosis of invasive aspergillosis.

Folia Microbiol (Praha) 2018 May 30. Epub 2018 May 30.

Department of Parasitology-Mycology, Besançon University Hospital, Besançon, France.

Galactomannan antigen (GM) testing has been used for decades to screen immunocompromised patients for invasive aspergillosis (IA). Recent publications suggested that using a higher cut-off value than 0.5 in bronchoalveolar lavage fluid (BALF) could be more discriminant for hematology patients. Read More

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Penetration of the Human Pulmonary Epithelium by Aspergillus fumigatus Hyphae.

J Infect Dis 2018 May 26. Epub 2018 May 26.

Inserm UMR, Physiopathologie et Epidémiologie des Maladies Respiratoires, Paris, France.

The airway epithelium is the first barrier interacting with Aspergillus fumigatus conidia after their inhalation, suggesting that this structure functions as point of entry of this fungus to initiate pulmonary aspergillosis. To study epithelial entry by A. fumigatus, primary human reconstituted pseudo-stratified epithelium cultured in air-liquid interface as well as bronchial epithelial cell monolayers were infected with conidia. Read More

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Voriconazole associated mucormycosis in a patient with relapsed acute lymphoblastic leukemia and hematopoietic stem cell transplant failure: A case report.

J Mycol Med 2018 May 25. Epub 2018 May 25.

Department of Medical Mycology, School of Medicine/Invasive Fungi Research Center (IFRC), Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

The patients with hematologic malignancies and hematopoietic stem cell transplantation (HSCT) recipients are at high risk for invasive fungal diseases (IFDs) mainly due to the severe and prolonged neutropenia related to high-dose chemotherapy. Voriconazole prophylaxis is recommended for possible IFDs. Mucormycosis is a fulminant infection, which may occur after voriconazole prophylaxis for invasive aspergillosis in immunocompromised hosts. Read More

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Use of Galactomannan Antigen and Aspergillus DNA Real-time Polymerase Chain Reaction as Routine Methods for Invasive Aspergillosis in Immunosuppressed Children in Greece.

Clin Ther 2018 Jun 26;40(6):918-924.e2. Epub 2018 May 26.

Department of Microbiology, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: Invasive aspergillosis (IA) remains a critical issue in immunosuppressed patients. Detection of galactomannan antigen (GM) in serum samples is included as a criterion of IA by the European Organization for the Research and Treatment of Cancer/Mycoses Study Group. Nevertheless, Aspergillus DNA detection by polymerase chain reaction (PCR) has not yet been included because clinical data validation is lacking. Read More

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Mycobacterium avium intracellulare infection complicated by allergic bronchopulmonary aspergillosis in a non-asthmatic patient.

BMJ Case Rep 2018 May 26;2018. Epub 2018 May 26.

Internal Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.

Allergic bronchopulmonary aspergillosis (ABPA) most often develops in patients with asthma or cystic fibrosis. We present a 91-year-old non-asthmatic patient with pre-existing Mycobacteriumavium complex (MAC) infection who got diagnosed with ABPA. Treatment of the two conditions can be challenging as immunosuppression with steroids for treatment of ABPA may exacerbate the underlying MAC infection. Read More

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May 2018
2 Reads

Aspergillosis, Eosinophilic Esophagitis, and allergic rhinitis in STAT3 Haploinsufficiency.

J Allergy Clin Immunol 2018 May 24. Epub 2018 May 24.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD. Electronic address:

STAT3 haploinsufficiency caused by a novel STAT3 splice site mutation is associated with elevated IgE, allergic rhinitis, eosinophilic esophagitis, and invasive aspergillosis. This case expands our understanding of the spectrum of disease associated with STAT3 mutations. Read More

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May 2018
2 Reads

[Invasive pulmonary aspergillosis in children with hepatic transplant: a survivor].

Rev Chil Pediatr 2018 Apr;89(2):241-245

Departamento de Trasplantes y Centro de Investigaciones Clínicas, Fundación Valle del Lili, Colombia.

Introduction: Mycotic infections due to Aspergillus spp, are the main mycotic associated infections in liver transplant patients, with mortality rates up to 90% of the cases. Almost 50% of patients will de velop an infection during the first months after transplantation, of which 10% are associated with op portunistic agents.

Objective: To describe the diagnosis and management of an Invasive Pulmonary Aspergillosis (IPA) episode in a liver transplant patient. Read More

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Invasive aspergillosis in patients following umbilical cord blood transplant.

Bone Marrow Transplant 2018 May 24. Epub 2018 May 24.

Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, MI, USA.

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Early diagnosis of fungal infections in lung transplant recipients, colonization versus invasive disease?

Curr Opin Organ Transplant 2018 May 21. Epub 2018 May 21.

Multi-Organ Transplant Program, Division of Infectious Diseases, Transplant Infectious Diseases, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada.

Purpose Of Review: The diagnosis of invasive aspergillosis remains challenging in solid organ transplants in general, and in lung transplant recipients, in particular, because of colonization. Lung transplant recipients may be over treated with antifungal drugs because of the lack of appropriate diagnostic tools.

Recent Findings: A review of the new developments of diagnostic tools and whether this help distinguishing colonization from invasive disease is presented. Read More

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