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    The Management of Chronic Pulmonary Aspergillosis: The UK National Aspergillosis Centre Approach.
    Curr Fungal Infect Rep 2017 13;11(4):242-251. Epub 2017 Nov 13.
    The National Aspergillosis Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Southmoor Road, Manchester, M23 9LT UK.
    Purpose Of Review: Chronic pulmonary aspergillosis (CPA) is a serious long-term fungal disease of the lung with a worldwide prevalence. Treatment of CPA is not straightforward given the often-multiple associated co-morbidities, complex clinical picture, drug interactions, toxicities and intolerances.

    Recent Findings: First line treatment is oral itraconazole or voriconazole. Read More

    Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis.
    Sci Rep 2017 Dec 6;7(1):17096. Epub 2017 Dec 6.
    Nutrional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia Tech., Blacksburg, VA, 24061, USA.
    Incidences of invasive pulmonary aspergillosis, an infection caused predominantly by Aspergillus fumigatus, have increased due to the growing number of immunocompromised individuals. While A. fumigatus is reliant upon deficiencies in the host to facilitate invasive disease, the distinct mechanisms that govern the host-pathogen interaction remain enigmatic, particularly in the context of distinct immune modulating therapies. Read More

    Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia.
    BMC Genomics 2017 Dec 4;18(1):942. Epub 2017 Dec 4.
    Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8673, Japan.
    Background: Aspergillus fumigatus is a human fungal pathogen that causes aspergillosis in immunocompromised hosts. A. fumigatus is believed to be exposed to diverse environmental stresses in the host cells. Read More

    Preexisting Cerebral Aspergillosis Successfully Treated After Liver Transplantation: A Case Report.
    Transplant Proc 2017 Dec;49(10):2402-2405
    Department of Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea. Electronic address:
    Background: Invasive aspergillosis (IA) is a rare condition that generally affects immunosuppressed patients. The mortality of IA is known to be >90% in liver transplantation (LT) recipients; the lung is the most commonly affected organ, followed by the brain. There have been reports in the literature of cerebral aspergillosis (CA) in LT recipients. Read More

    Long-term outcomes and prognostic factors in patients with mild hemoptysis.
    Am J Emerg Med 2017 Nov 27. Epub 2017 Nov 27.
    Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Gyeonggi-Do, South Korea.
    Objective: The aim of this retrospective study was to observe the long-term outcomes of conservative treatment and bronchial artery embolization (BAE) in patients with mild hemoptysis and to analyze the risk factors associated with hemoptysis recurrence.

    Methods: Patients with mild hemoptysis from January 2005 to January 2016 were enrolled in this study. The patients' medical records, including smoking history, etiologic diseases, bronchoscopic findings, mortality, BAE information, and follow-up data of recurrent hemoptysis, were reviewed and analyzed. Read More

    Impact of unresolved neutropenia in patients with neutropenia and invasive aspergillosis: a post hoc analysis of the SECURE trial.
    J Antimicrob Chemother 2017 Nov 29. Epub 2017 Nov 29.
    Infectious Disease, UT Health San Antonio and the South Texas Veterans Health Care System, San Antonio, TX, USA.
    Background: Historically, baseline neutropenia and lack of neutrophil recovery have been associated with poor outcomes in invasive aspergillosis (IA). It is unclear how treatment with the new Aspergillus-active triazoles isavuconazole and voriconazole affects outcomes in neutropenic patients with IA.

    Methods: A post hoc analysis of the Phase 3 SECURE trial assessed patients with neutropenia (neutrophil count <0. Read More

    Primary cutaneous aspergillosis, mimicking malignancy, a rare presentation in an immunocompetent patient.
    Diagn Cytopathol 2017 Nov 30. Epub 2017 Nov 30.
    Department of Pathology, Seth G.S.M.C & K.E.M.H, Mumbai, Maharashtra, India.
    Aspergillus species are ubiquitous opportunistic molds that cause both allergic and invasive syndromes. A 65-year-old female, farmer by occupation, presented with left upper limb and trunk swelling for one year, associated with pain, tightening of skin, and vesicles with watery discharge. Local examination showed a diffuse swelling extending from left arm to forearm and lateral chest wall associated with edema, induration, and raised temperature. Read More

    Diagnostic performance of the (1-3)-β-D-glucan assay in patients with Pneumocystis jirovecii compared with those with candidiasis, aspergillosis, mucormycosis, and tuberculosis, and healthy volunteers.
    PLoS One 2017 30;12(11):e0188860. Epub 2017 Nov 30.
    Departments of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    Background: Diagnosis of pneumocystis pneumonia (PCP) relies on microscopic visualization of P. jirovecii, or detection of Pneumocystis DNA in respiratory specimens, which involves invasive procedures such as bronchoalveolar lavage. The (1-3)-β-D-glucan (BG) assay has been proposed as a less invasive and less expensive diagnostic test to rule out PCP. Read More

    Risk factors for the development of chronic pulmonary aspergillosis in patients with nontuberculous mycobacterial lung disease.
    PLoS One 2017 30;12(11):e0188716. Epub 2017 Nov 30.
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Nontuberculous mycobacterial lung disease (NTM-LD) is increasingly recognized as an important predisposing condition for the development of chronic pulmonary aspergillosis (CPA), but there are limited data on the risk factors for CPA development in NTM-LD patients. We reviewed the medical records of 566 patients who, at the time of diagnosis of NTM-LD, did not have CPA and who received ≥12 months of treatment for NTM-LD between January 2010 and June 2015. Of these patients, 41 (7. Read More

    Tumor shape pulmonary mucormycosis associated with sinonasal aspergillosis in a diabetic patient.
    Med Mycol Case Rep 2018 Mar 1;19:13-17. Epub 2017 Sep 1.
    Pneumology Department, Hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac, France.
    Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. Read More

    [Small Animal Aspergillosis and Cryptococcosis in Japan].
    Med Mycol J 2017 ;58(4):J121-J126
    Department of Veterinary Pathobiology, Nihon University College of Bioresouce Sciences.
     Canine and feline upper respiratory tract (URT) infection due to Aspergillus spp. is considered an emerging disease, with the number of reported cases continuing to rise in Japan. Aspergillus fumigatus has been the most frequently reported etiologic agent of sino-orbital aspergillosis in dogs and cats; the other Aspergillus species, Aspergillus felis, Aspergillus fischeri, Aspergillus udagawae, Aspergillus viridinutans, and A. Read More

    [Preparation and Biological Characterization of Limulus Factor G-activating Substance of Aspergillus spp.]
    Med Mycol J 2017 ;58(4):E121-E129
    Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
    Aspergillus is a medically important fungal genus that causes a life-threatening infection known as aspergillosis in immunocompromised patients. β-1,3-Glucan is detected in the plasma of patients with aspergillosis and appears to be useful for the diagnosis of aspergillosis. In this study, we cultured Aspergillus spp. Read More

    Recommendations for the management of pulmonary fungal infections in patients with rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Nov 28. Epub 2017 Nov 28.
    Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.
    Often life-threatening pulmonary fungal infections (PFIs) can occur in patients with rheumatoid arthritis (RA) receiving disease-modifying anti-rheumatic drugs (DMARDs). Most of the data concerning PFIs in RA patients come from case reports and retrospective case series. Of the ve most widely described PFIs, Pneumocystis jirovecii pneumonia (PJP) has rarely been seen outside Japan, pulmonary cryptococcosis has been diagnosed in only a small number of patients worldwide, pulmonary coccidioidomycosis has almost only been observed in endemic areas, the limited number of cases of pulmonary histoplasmosis have mainly occurred in the USA, and the rare cases of invasive pulmonary aspergillosis have only been encountered in leukopenic patients. Read More

    Non-invasive and invasive diagnoses of aspergillosis in a rat model by mass spectrometry.
    Sci Rep 2017 Nov 28;7(1):16523. Epub 2017 Nov 28.
    Institute of Microbiology of the Czech Academy of Sciences, Prague 4, 142 20, Czech Republic.
    Invasive pulmonary aspergillosis results in 450,000 deaths per year and complicates cancer chemotherapy, transplantations and the treatment of other immunosuppressed patients. Using a rat model of experimental aspergillosis, the fungal siderophores ferricrocin and triacetylfusarinine C were identified as markers of aspergillosis and quantified in urine, serum and lung tissues. Biomarkers were analyzed by matrix-assisted laser desorption ionization (MALDI) and electrospray ionization mass spectrometry using a 12T SolariX Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. Read More

    Aspergillus Osteomyelitis of the Ribs in Immunocompetent Hosts: Report of Two Rare Cases.
    J Orthop Case Rep 2017 Jul-Aug;7(4):61-64
    Department of Orthopedics, P.D. Hinduja Hospital and Medical Research Centre, Mahim, Mumbai, Maharashtra, India.
    Introduction: Osteomyelitis is rarely caused by fungi, most common among them being Candida. Aspergillus is a rare cause of fungal osteomyelitis mimics tuberculous osteomyelitis. Aspergillus osteomyelitis (AO) of the ribs is relatively uncommon, with an incidence rate of only 9% among all reported cases of AO. Read More

    Gastrointestinal tuberculosis following renal transplantation accompanied with septic shock and acute respiratory distress syndrome: a survival case presentation.
    BMC Gastroenterol 2017 Nov 28;17(1):131. Epub 2017 Nov 28.
    University Hospital Bratislava, Nemocnica Ruzinov, ICU, KAIM, Clinic of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.
    Background: Post-transplant tuberculosis (PTTB) is a serious opportunistic infection in renal graft recipients with a 30-70 fold higher incidence compared to the general population. PTTB occurs most frequently within the first years after transplantation, manifesting as pulmonary or disseminated TB. Gastrointestinal TB (GITB) is a rare and potentially lethal manifestation of PTTB and may show delayed onset in renal transplant recipients due to the use of lower doses of immunosuppressants. Read More

    Isavuconazole shortens the QTc interval.
    Mycoses 2017 Nov 25. Epub 2017 Nov 25.
    Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
    Background: Isavuconazole is a novel antifungal drug, approved for treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose-related manner. Here, we assessed the effects of isavuconazole on the length of QTc interval. Read More

    Monitoring of clinical strains and environmental fungal aerocontamination to prevent invasive aspergillosis infections in hospital during large deconstruction work: a protocol study.
    BMJ Open 2017 Nov 25;7(11):e018109. Epub 2017 Nov 25.
    Laboratoire des Pathogènes Emergents-Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), Université de Lyon, Lyon, France.
    Introduction: Monitoring fungal aerocontamination is an essential measure to prevent severe invasive aspergillosis (IA) infections in hospitals. One central block among 32 blocks of Edouard Herriot Hospital (EHH) was entirely demolished in 2015, while care activities continued in surrounding blocks. The main objective was to undertake broad environmental monitoring and clinical surveillance of IA cases to document fungal dispersion during major deconstruction work and to assess clinical risk. Read More

    Omalizumab treatment for allergic bronchopulmonary aspergillosis in young patients with cystic fibrosis.
    Respir Med 2017 Dec 10;133:12-15. Epub 2017 Nov 10.
    APHP, Hôpital Trousseau, Cystic Fibrosis Center, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, INSERM, Centre de Recherche Saint-Antoine (CRSA), F-75012, Paris, France. Electronic address:
    Background: Allergic bronchopulmonary aspergillosis (ABPA) is a severe lung disease complication caused by an Aspergillus fumigatus-induced hypersensitivity that affects 2-15% of patients with cystic fibrosis (CF). The mainstay treatment consists of a combination of corticosteroids and antifungals. However, repeated or long-term corticosteroid therapies can lead to serious side effects. Read More

    In vitro antifungal susceptibility of clinical and environmental isolates of Aspergillus fumigatus and Aspergillus flavus in Brazil.
    Braz J Infect Dis 2017 Nov 21. Epub 2017 Nov 21.
    Universidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas, Santa Maria, RS, Brazil; Universidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Laboratório de Pesquisas Micológicas, Santa Maria, RS, Brazil.
    The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC>2. Read More

    Galactomannan use in clinical practice: providing free testing is not the answer.
    Braz J Infect Dis 2017 Nov 21. Epub 2017 Nov 21.
    Santa Casa de Misericórdia, Porto Alegre, RS, Brazil; Universidade Federal de Ciências da Saúde, Porto Alegre, RS, Brazil. Electronic address:
    Introduction: Invasive aspergillosis (IA) is a condition associated with a high mortality rate due to difficulties in performing an early diagnosis. In recent years, galactomannan (GM) detection has markedly improved the diagnosis of IA, but very little is known on how physicians deal with this test in clinical practice.

    Methods: This cross-sectional study aimed to analyze the indications for the use of serum GM in a large Brazilian hospital, between 2015 and 2016. Read More

    Role of actin depolymerizing factor cofilin in Aspergillus fumigatus oxidative stress response and pathogenesis.
    Curr Genet 2017 Nov 23. Epub 2017 Nov 23.
    Institute for Disease Control and Prevention of PLA, Academy of Military Medical Sciences, 20# Dongda Str., 100071, Beijing, China.
    Aspergillus fumigatus is a major fungal pathogen that is responsible for approximately 90% of human aspergillosis. Cofilin is an actin depolymerizing factor that plays crucial roles in multiple cellular functions in many organisms. However, the functions of cofilin in A. Read More

    Systematic Review: Occupational illness in the waste and recycling sector.
    Occup Med (Lond) 2017 Dec;67(8):626-636
    Department of Occupational Health, Sheffield Teaching Hospitals NHS Trust, UK.
    Background: The waste and recycling sector is a growing part of industry. Whether health surveillance is indicated and how it should be undertaken is unclear.

    Aims: To undertake a review of the literature to identify hazards to health, biological effects and occupational illnesses for workers in the sector. Read More

    Circulating Aspergillus fumigatus DNA Is Quantitatively Correlated to Galactomannan in Serum.
    Front Microbiol 2017 31;8:2040. Epub 2017 Oct 31.
    Laboratoire de Parasitologie-Mycologie, APHP, Paris, France.
    The performance of antigen galactomannan (GM) for diagnosing invasive aspergillosis (IA) is hampered by the occurrence of false-positive results. Quantitative PCR has been proposed to improve the diagnosis of IA. Therefore, we analyzed the value of performing a PCR test to the GM-positive serum sample. Read More

    Elevated Aspergillus-specific antibody levels among HIV infected Ugandans with pulmonary tuberculosis.
    BMC Pulm Med 2017 Nov 21;17(1):149. Epub 2017 Nov 21.
    The University of Manchester, Manchester, UK.
    Background: The incidence of tuberculosis (TB) is high among human immunodeficiency virus (HIV) infected Ugandans. Recent evidence suggests that Chronic Pulmonary Aspergillosis and Aspergillus sensitisation might be responsible for significant mortality in patients treated for tuberculosis in Uganda.

    Methods: We retrieved and tested paired serum aliquots for 101 HIV-TB co-infected patients at the beginning and week 24 of TB treatment. Read More

    CT and MRI Findings in Cerebral Aspergilloma.
    Rofo 2017 Nov 20. Epub 2017 Nov 20.
    Department of Radiology and Neuroradiology, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Germany.
    Purpose Invasive aspergillosis usually affects immunocompromised patients. It carries a high risk of morbidity and mortality and usually has a nonspecific clinical presentation. Early diagnosis is essential in order to start effective treatment and improve clinical outcome. Read More

    Limited evidence of fungicide-driven triazole resistant Aspergillus fumigatus in Hamilton, Canada.
    Can J Microbiol 2017 Nov 20. Epub 2017 Nov 20.
    Department of Biology , LSB437 , McMaster University , Hamilton, Ontario, Canada , L8S 4K1 ;
    Aspergillus fumigatus is a ubiquitous opportunistic fungal pathogen that can cause aspergillosis in humans. Over the last decade there have been increasing global reports of treatment failure due to triazole resistance. An emerging hypothesis states that agricultural triazole fungicide use causes clinical triazole-resistance. Read More

    Modulating host immune responses to fight invasive fungal infections.
    Curr Opin Microbiol 2017 Nov 15;40:95-103. Epub 2017 Nov 15.
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK; Botswana UPenn Partnership, Gaborone, Botswana; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
    Modulation of host immunity in invasive fungal infection is an appealing but as yet mostly elusive treatment strategy. Animal studies in invasive candidiasis and aspergillosis have demonstrated beneficial effects of colony stimulating factors, interferon-gamma and monoclonal antibodies. More recent studies transfusing leukocytes pre-loaded with lipophilic anti-fungal drugs, or modulated T-cells, along with novel vaccination strategies show great promise. Read More

    Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial.
    Lancet Haematol 2017 Dec 15;4(12):e573-e583. Epub 2017 Nov 15.
    Department of Infectious Diseases, Microbiology, and Preventive Medicine, University Hospital Virgen del Rocío-Institute of Biomedicine of Seville, Seville, Spain. Electronic address:
    Background: Continuation of empirical antimicrobial therapy (EAT) for febrile neutropenia in patients with haematological malignancies until neutrophil recovery could prolong the therapy unnecessarily. We aimed to establish whether EAT discontinuation driven by a clinical approach regardless of neutrophil recovery would optimise the duration of therapy.

    Methods: We did an investigator-driven, superiority, open-label, randomised, controlled phase 4 clinical trial in six academic hospitals in Spain. Read More

    Multiple pulmonary metastases with halo-sign from malignant mixed Müllerian tumors.
    Oncol Lett 2017 Dec 22;14(6):6645-6649. Epub 2017 Sep 22.
    Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
    The lungs are one of the most common organs to which cancer metastasizes, but are a location not common for uterine sarcoma. A malignant mixed Müllerian tumor (MMMT) of the uterus is an extremely rare and aggressive sarcoma, characterized by a mixture of epithelial and mesenchymal components. There are few reports regarding the pulmonary metastasis from MMMTs. Read More

    The Influence of Genetic Stability on Aspergillus fumigatus Virulence and Azole Resistance.
    G3 (Bethesda) 2017 Nov 17. Epub 2017 Nov 17.
    Universidade de Sao Paulo
    Genetic stability is extremely important for the survival of every living organism and a very complex set of genes have evolved to cope with DNA repair upon DNA damage. Here, we investigated the Aspergillus fumigatus AtmA (Ataxia-telangiectasia mutated) and AtrA kinases and how they impact virulence and the evolution of azole resistance. We demonstrated that A. Read More

    A Review of Onychomycosis Due to Aspergillus Species.
    Mycopathologia 2017 Nov 16. Epub 2017 Nov 16.
    The National Aspergillosis Centre, Education and Research Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT, UK.
    Aspergillus spp. are emerging causative agents of non-dermatophyte mould onychomycosis (NDMO). New Aspergillus spp. Read More

    Infectious and Non-Infectious Diseases Causing the Air Crescent Sign: A State-of-the-Art Review.
    Lung 2017 Nov 15. Epub 2017 Nov 15.
    Federal University of Rio de Janeiro, Rua Thomaz Cameron, 438, Valparaiso, Petrópolis, Rio de Janeiro, CEP, 25685-120, Brazil.
    Aspergilloma, also known as mycetoma or fungus ball, is characterized by a round or oval mass with soft-tissue attenuation within a preexisting lung cavity. The typical computed tomography (CT) aspect of an aspergilloma is a mass separated from the wall of the cavity by an airspace of variable size and shape, resulting in the air crescent sign, also known as the meniscus sign. This CT feature is non-specific and can be simulated by several other entities that result in intracavitary masses. Read More

    Aspergillus Infection in an Immunocompetent Host With Supravalvular Aortic Stenosis.
    World J Pediatr Congenit Heart Surg 2017 Jan 1:2150135117725456. Epub 2017 Jan 1.
    1 Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
    Supravalvular aortic stenosis is the rarest form of left ventricular outflow tract obstruction. Aspergillus endocarditis is also rare and generally reported in immunocompromised hosts. Here we present a case of an immunocompetent patient with supravalvular aortic stenosis complicated by aortic mycotic pseudoaneurysm due to invasive aspergillosis. Read More

    Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A. nidulans.
    Mycopathologia 2017 Nov 11. Epub 2017 Nov 11.
    Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 15006, Prague 5, Czech Republic.
    Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Read More

    Evaluation of the efficacy of a posaconazole and anidulafungin combination in a murine model of pulmonary aspergillosis due to infection with Aspergillus fumigatus.
    Diagn Microbiol Infect Dis 2018 Jan 12;90(1):40-43. Epub 2017 Oct 12.
    Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil; Laboratório de Pesquisas Micológicas, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria, UFSM, Santa Maria, RS, Brasil.
    Posaconazole (PSC) in combination with anidulafungin (AFG) was evaluated in a murine model of pulmonary aspergillosis. Immunosuppressed animals were infected via the nasal cavity with 2 different A. fumigatus strains. Read More

    A CPAnet consensus statement on research priorities for chronic pulmonary aspergillosis: a neglected fungal infection that requires attention.
    J Antimicrob Chemother 2017 Nov 6. Epub 2017 Nov 6.
    Division of Clinical Infectious Diseases and German Centre for Infection Research Tuberculosis Unit, Research Centre Borstel, Borstel, Germany.
    Chronic pulmonary aspergillosis (CPA) is a severe fungal infection with a high morbidity and mortality, and is usually seen in immunocompetent patients with respiratory disorders. Clinical presentation is nonspecific and often overlaps with the symptoms and the radiological pattern caused by the underlying disease. Clinical management of CPA is further hampered by limited information about the epidemiology, disease dynamics, sensitivity and specificity of different mycological tests, mechanisms of antifungal resistance, efficient treatment and management strategies. Read More

    Outbreak of invasive aspergillosis in heart transplant recipients: The role of screening computed tomography scans in asymptomatic patients and universal antifungal prophylaxis.
    Transpl Infect Dis 2017 Nov 10. Epub 2017 Nov 10.
    Division of Infectious Diseases, University of Toronto, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
    Background: Delays in diagnosing invasive pulmonary aspergillosis (IA), a significant cause of morbidity and mortality among heart transplant recipients (HTRs), may impact on successful treatment. The appropriate screening strategy for IA in these patients remains undefined, particularly in the setting of nosocomial outbreaks. We describe our experience employing chest computed tomography (CT) scans as a screening method for IA. Read More

    Primary prophylaxis of invasive fungal infections with posaconazole or itraconazole in patients with acute myeloid leukemia or high-risk myelodysplastic syndromes undergoing intensive cytotoxic chemotherapy: a real world comparison.
    Mycoses 2017 Nov 10. Epub 2017 Nov 10.
    Hematology Service, Hospital Clínico Universitario-INCLIVA, Valencia.
    This is an observational-retrospective study comparing the real-world outcomes associated with posaconazole vs. itraconazole as prophylaxis treatments. Two hundred and ninety-three patient admissions attributable to 174 patients were included in the study. Read More

    Use of 1,3-β-D-glucan in invasive fungal diseases in hematology patients.
    Expert Rev Anti Infect Ther 2017 Dec 20;15(12):1101-1112. Epub 2017 Nov 20.
    a Infectious Diseases Unit, Ospedale Policlinico San Martino, IRCCS per l'Oncologia, University of Genoa, DISSAL , Genoa , Italy.
    Introduction: Invasive fungal diseases (IFD) remain a leading cause of morbidity and mortality in hematology patients. Within a diagnostic-driven approach, the use of the serum (1,3)-ß-D-glucan (BDG) test represents a valid tool for the early diagnosis and treatment of IFD. Areas covered: The available literature on the use of BDG in hematology patients was systematically retrieved. Read More

    Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.
    J Allergy Clin Immunol 2017 Nov 6. Epub 2017 Nov 6.
    University of Manchester, Faculty of Biology, Medicine and Health, Manchester Fungal Infection Group, Institute of Inflammation and Repair, Core Technology Facility, Manchester, UK; University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester (UHSM), Manchester, UK. Electronic address:
    Background: Allergic diseases caused by fungi are common. The best understood conditions are allergic bronchopulmonaryaspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS). Our knowledge of the fungal microbiome (mycobiome) is limited to a few studies involving healthy individuals, asthmatics and smokers. Read More

    Necrotizing Microascus tracheo-bronchitis in a bilateral lung transplant recipient.
    Transpl Infect Dis 2017 Nov 9. Epub 2017 Nov 9.
    Department of Microbiology, CUB-Erasme, Université Libre de Bruxelles, Brussels, Belgium.
    Invasive fungal infections are a major cause of mortality among solid organ transplant recipients. Scopulariopsis species and their teleomorph Microascus are molds found in soil and decaying organic matter. We report here the case of a woman who underwent bilateral lung transplantation for severe emphysema. Read More

    Predicting invasive aspergillosis in haematology patients by combining clinical and genetic risk factors with early diagnostic biomarkers.
    J Clin Microbiol 2017 Nov 8. Epub 2017 Nov 8.
    Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, UK.
    The incidence of invasive aspergillosis (IA) in high risk haematology populations, is relatively low (<10%), despite unavoidable exposure Aspergillus in patients with potentially similar clinical risk. Non-clinical variables including genetic mutations that increase susceptibility to IA could explain why only certain patients develop disease. This study aimed to screen for mutations in 322 haematology patients classified according to IA status, and to develop a predictive model based on genetic risk, established clinical risk factors and diagnostic biomarkers. Read More

    False-positive galactomannan assay in broncho-alveolar lavage after enteral nutrition solution inhalation: a case report.
    JMM Case Rep 2017 Sep 18;4(9):e005116. Epub 2017 Sep 18.
    Department of Intensive Care, CUB - Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070 Brussels, Belgium.
    Introduction. Diagnosis of invasive aspergillosis is challenging and the gold standard for definite diagnosis remains histopathological tissue examination. However, invasive procedures such as lung biopsy are often not feasible in critically ill patients. Read More

    Real-world challenges and unmet needs in the diagnosis and treatment of suspected invasive pulmonary aspergillosis in patients with haematological diseases: An illustrative case study.
    Mycoses 2017 Nov 7. Epub 2017 Nov 7.
    Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University Graz, Graz, Austria.
    Recent years have seen important advances in the diagnosis of invasive pulmonary aspergillosis (IPA), complemented by the introduction of new therapies. Despite this, IPA remains a major cause of infection-related mortality in patients with haematological diseases. There are two main reasons for this. Read More

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