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    Burden of Serious Fungal Infections in Argentina.
    J Fungi (Basel) 2018 Apr 24;4(2). Epub 2018 Apr 24.
    The Natonal Aspergillosis Centre, Wythenshawe Hospital, Manchester Academic Health Science Centre, and The University of Manchester, Manchester M23 9LT, UK.
    The number of fungal infections at any given time in Argentina is not known. Here we estimate the burden of serious fungal infections in Argentina for the first time. Specific population statistics were searched from multiple sources, local literature was identified, and estimates made. Read More

    Performance of serum (1,3)-ß-D-glucan screening for the diagnosis of invasive aspergillosis in neutropenic patients with haematological malignancies.
    Mycoses 2018 Apr 25. Epub 2018 Apr 25.
    Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l'Oncologia and Department Health Science (DISSAL), University of Genoa, Genoa, Italy.
    Objectives: To report our experience with the use of (1,3)-ß-D-glucan (BDG) screening for the diagnosis of invasive aspergillosis (IA) in neutropenic patients with haematological malignancies.

    Methods: The performance of BDG screening was assessed retrospectively through per patient and per sample analyses.

    Results: Overall, 20 among 167 patients developed IA (12%). Read More

    The diagnosis and treatment of invasive aspergillosis in Dutch haematology units facing a rapidly increasing prevalence of azole resistance. A nationwide survey and rationale for the DB-MSG 002 study protocol.
    Mycoses 2018 Apr 23. Epub 2018 Apr 23.
    Department of Internal Medicine, section of Infectious Diseases, Erasmus University Medical Center, Rotterdam, Netherlands.
    Background: Patients with haematological malignancies are at risk for invasive fungal diseases (IFD). A survey was conducted in all Dutch academic haematology centres on their current diagnostic, prophylactic and therapeutic approach towards IFD in the context of azole resistance.

    Methods: In all 8 centres, a haematologist and microbiologist filled in the questionnaire that focused on different subgroups of haematology patients. Read More

    Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright.
    Front Microbiol 2018 9;9:691. Epub 2018 Apr 9.
    Department of Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom.
    Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of immuno-compromised humans caused by the ubiquitous environmental mold . Biomarker tests for the disease lack sensitivity and specificity, and culture of the fungus from invasive lung biopsy is slow, insensitive, and undesirable in critically ill patients. A computed tomogram (CT) of the chest offers a simple non-intrusive diagnostic procedure for rapid decision making, and so is used in many hematology units to drive antifungal treatment. Read More

    Urine Antigen Detection as an Aid to Diagnose Invasive Aspergillosis.
    Clin Infect Dis 2018 Apr 19. Epub 2018 Apr 19.
    Lenox Hill Hospital, N.Y., N.Y.
    Background: Establishing rapid diagnoses of invasive aspergillosis (IA) is priority, given poor outcomes of late therapy. Non-culture based tests that detect galactomannan and β-D glucan are available, but are technically cumbersome and rely on invasive sampling (blood or bronchoalveolar lavage).

    Methods: We optimized a lateral flow dipstick assay using the galactofuranose -specific monoclonal antibody (mAb476), which was previously shown to recognize urine antigens after Aspergillus fumigatus pulmonary infection in an`imals. Read More

    Serum galactomannan antigen as a prognostic and diagnostic marker for invasive aspergillosis in heterogeneous medicine ICU patient population.
    PLoS One 2018 23;13(4):e0196196. Epub 2018 Apr 23.
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
    Objective: This study was conducted to get a complete clinical and mycological picture of invasive aspergillosis (IA) in respiratory medicine ICU of a tertiary care hospital.

    Patients: From the cohort of 235 patients only one had proven IA. Based on AspICU algorithm, 21 had putative IA (8. Read More

    Aspergilloma Mimicking Olfactory Groove Meningioma.
    Asian J Neurosurg 2018 Apr-Jun;13(2):436-439
    Department of Neurosurgery, SGPGIMS, Lucknow, Uttar Pradesh, India.
    Central nervous system aspergillosis is rare with reported mortality rate of 13-50% involving foci in paranasal sinuses and even higher mortality rates (80-100%) in patients of immune-compromised status. Modern day imaging offers an opportunity for early diagnosis, but findings are minimal. A typical finding is that of a space occupying mass lesion with iso-hypointense signal on T1-weighted sequences and extreme hypointense appearance on T2-weighted. Read More

    Fungal Infections in Hematopoietic Stem Cell Transplantation in Children at a Pediatric Children's Hospital in Argentina.
    Transpl Infect Dis 2018 Apr 20:e12913. Epub 2018 Apr 20.
    Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.
    Our primary objective was to describe the incidence of proven or probable invasive fungal infections (IFIs), a devastating complication of hematopoietic stem cell transplant (HSCT), in HCST in a middle-income country. Secondary objectives were to describe factors associated with IFIs and outcomes. In this single center retrospective study, pediatric patients who underwent a first allogeneic or autologous HSCT from 1998 to 2016 were included. Read More

    De-escalation of antifungal treatment in critically ill patients with suspected invasive Candida infection: incidence, associated factors, and safety.
    Ann Intensive Care 2018 Apr 19;8(1):49. Epub 2018 Apr 19.
    Critical Care Center, CHU Lille, 59000, Lille, France.
    Background: Antifungal treatment is common in critically ill patients, but only a small proportion of patients receiving antifungals have a proven fungal infection. However, antifungal treatment has side effects such as toxicity, emergence of resistance, and high cost. Moreover, empirical antifungal treatment is still a matter for debate in these patients. Read More

    Massive haemoptysis secondary to mycotic pulmonary artery aneurysm in subacute invasive aspergillosis.
    BMJ Case Rep 2018 Apr 19;2018. Epub 2018 Apr 19.
    Department of Respiratory Medicine, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.
    A 68-year-old man, presented with 3 week history of infective symptoms and mild haemoptysis. Past medical history included severe emphysema and a chronic right upper lobe (RUL) cavity. He was discharged from follow-up a year ago in view of clinical and radiological stability; previous bronchoscopic examinations yielded no specific diagnosis. Read More

    Galactomannan, a Surrogate Marker for Outcome in Invasive Aspergillosis: Finally Coming of Age.
    Front Microbiol 2018 4;9:661. Epub 2018 Apr 4.
    Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
    Detection of galactomannan has become widely available for diagnosing invasive aspergillosis. The test characteristics, using the Platelia™ enzyme-immunoassay, have been well described. This assay could potentially also be useful for the early evaluation of the efficacy of antifungal therapy and for predicting the outcome in terms of response and survival. Read More

    Aspergillus Infection of the Larynx in a Solid Organ Transplant Recipient.
    Transpl Infect Dis 2018 Apr 18:e12900. Epub 2018 Apr 18.
    Department of Infectious Diseases Mineral Metabolism and Transplant, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City, Mexico.
    Primary laryngeal aspergillosis is a rare condition. Only a few cases have been reported in the past years. Most of them have been reported in healthy patients or with a mild immunocompromised state. Read More

    Epidemiology, risk factors and outcomes of invasive aspergillosis in solid organ transplant recipients in the Swiss Transplant Cohort Study.
    Transpl Infect Dis 2018 Apr 18:e12898. Epub 2018 Apr 18.
    Transplant Infectious Diseases Unit, University Hospitals of Geneva, Geneva, Switzerland.
    Background: There is lack of recent multicenter epidemiological data on invasive aspergillosis (IA) among solid organ transplant recipient (SOTr) in the mold-acting antifungal era. We describe the epidemiology and outcomes of IA in a contemporary cohort of SOTr using the Swiss Transplant Cohort Study.

    Methods: All consecutive SOTr with proven or probable IA between 01. Read More

    Determination of an -Specific Immunoglobulin G Reference Range in an Adult Omani Population.
    Sultan Qaboos Univ Med J 2018 Feb 4;18(1):e43-e46. Epub 2018 Apr 4.
    Department of Microbiology & Immunology, Sultan Qaboos University Hospital, Muscat, Oman.
    Objectives: The presence of abnormally high levels of -specific immunoglobulin (Ig) G antibodies can serve as a diagnostic criterion for severe conditions like allergic bronchopulmonary and chronic pulmonary aspergillosis. This study aimed to determine a reference range of -specific IgG levels within a healthy adult Omani population.

    Methods: This study took place during November 2015 at the Sultan Qaboos University Hospital, Muscat, Oman. Read More

    Fungi-Induced Upper and Lower Respiratory Tract Allergic Diseases: One Entity.
    Front Microbiol 2018 3;9:583. Epub 2018 Apr 3.
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
    can cause different allergic diseases including allergic bronchopulmonary aspergillosis (ABPA) and allergic fungal rhinosinusitis (AFRS). ABPA is allergic pulmonary disease against antigens. AFRS is a type of chronic rhinosinusitis (CRS) presented as hypersensitivity reactions to the fungal presence in sinuses. Read More

    Severe asthma concomitant with allergic bronchopulmonary aspergillosis successfully treated with mepolizumab.
    Allergol Int 2018 Apr 14. Epub 2018 Apr 14.
    Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; Department of Allergy and Respiratory Medicine, Okayama Rosai Hospital, Okayama, Japan. Electronic address:

    Fungal infections in adult patients on extracorporeal life support.
    Crit Care 2018 Apr 17;22(1):98. Epub 2018 Apr 17.
    University Hospitals of Leicester, ECMO program, Glenfield Hospital, Groby Rd, Leicester, LE3 9QP, UK.
    Background: Patients on extracorporeal membrane oxygenation (ECMO) are often among the most severely ill in the intensive care unit. They are often receiving broad-spectrum antibiotics; they have multiple entry points for pathogens; and their immune system is impaired by blood circuit interaction. These factors are thought to predispose them to fungal infections. Read More

    Aspergillus sinusitis complicated with meningitis and multiple cerebral infarctions in immunocompetent patient.
    Neurosciences (Riyadh) 2018 Apr;23(2):148-151
    Departmentof Neurosurgery, National Care Hospital, Riyadh, Kingdom of Saudi Arabia. E-mail:
    This is a case of a 33-year-old male complaining of severe headache, neck pain, photophobia, vomiting and high-grade fever of several days. He had history of nasal polyp removal and recurrent sinusitis in the last 8 years. On examination: conscious with glasco coma scale (GCS) 15/15 and normal limbs strength but with positive Babinski sign. Read More

    Animal Models of Aspergillosis.
    Comp Med 2018 Apr;68(2):109-123
    Department of Pathology and Laboratory Medicine, Division of Comparative Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA., Email:
    Aspergillosis is an airborne fungal disease caused by Aspergillus spp., a group of ubiquitous molds. This disease causes high morbidity and mortality in both humans and animals. Read More

    Comparison of Two Molecular Assays for Detection and Characterization of Triazole Resistance and Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients.
    Front Microbiol 2018 27;9:555. Epub 2018 Mar 27.
    Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
    In hematological patients, the incidence of invasive aspergillosis (IA) caused by azole resistant (ARAf) is rising. As the diagnosis of IA is rarely based on positive culture in this group of patients, molecular detection of resistance mutations directly from clinical samples is crucial. In addition to the in-house azole resistance ARAf polymerase chain reaction (PCR) assays detecting the frequent mutation combinations TR34/L98H, TR46/Y121F/T289A, and M220 in the () gene by subsequent DNA sequence analysis, we investigated in parallel the commercially available AsperGenius® real time PCR system in detecting the alterations TR34/L98H and Y121F/T289A directly from 52 clinical samples (15 biopsies, 22 bronchoalveolar lavage (BAL), 15 cerebrospinal fluid (CSF) samples) and ARAf isolates ( = 3) of immunocompromised patients. Read More

    Pulmonary aspergillosis after treatment with infliximab in Still's disease and a literature review of Still's disease and pulmonary aspergillosis.
    Eur J Rheumatol 2018 Mar;5(1):75-78
    Division of Rheumatology, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.
    The use of anti-tumor necrosis factor alpha (anti-TNF-α) agents has increased during the past decade in rheumatology practice. Opportunistic infections have been reported with anti-TNF-α agents in clinical trials and post-marketing usage. Aspergillus infection is a rare opportunistic infection that is associated with immunosuppression, and there are reported cases of pulmonary aspergillosis in various rheumatic diseases treated with anti-TNF-α agents. Read More

    Isolated Acute Appendicitis Caused by Aspergillus in a Patient Who Underwent Lung Transplantation: A Case Report.
    Transplant Proc 2018 Apr 11. Epub 2018 Apr 11.
    Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea; Department of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
    Invasive aspergillosis is an important cause of morbidity and mortality in patients who have undergone lung transplantation. Aspergillus infections usually involve the respiratory tract, with vascular invasion and subsequent dissemination. However, acute appendicitis associated with localized aspergillosis is rare, especially among patients who have undergone prophylaxis with voriconazole. Read More

    Invasive tracheobronchial aspergillosis developed during radioimmunotherapy for malignant lymphoma.
    Clin Case Rep 2018 Apr 4;6(4):745-749. Epub 2018 Mar 4.
    Division of HematologyShonan Kamakura General HospitalKanagawaJapan.
    Invasive pulmonary aspergillosis (IPA) often occurs during the treatment of malignant lymphoma. However, invasive tracheobronchial aspergillosis (ITBA) is a rare form of IPA. Particularly, due to the decrease in immunity associated with chemotherapy, it is difficult to diagnose ITBA only by CT imaging and serological findings. Read More

    Performance of Molecular Approaches for Detection and Azole Resistance Surveillance in Cystic Fibrosis.
    Front Microbiol 2018 27;9:531. Epub 2018 Mar 27.
    Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Rennes, Rennes, France.
    triazole resistance is an emerging concern for treating chronically infected/colonized patients. This study sought to evaluate the performance of PCR assays to detect fungi together with azole resistance in sputum samples from cystic fibrosis (CF) patients. In total, 119 sputum samples from 87 CF patients were prospectively processed for detection by means of mycological culture and four qPCR assays, 2 in-house methods and two commercial multiplex real-time PCR assays simultaneously detecting and the most relevant gene mutations (MycoGENIE and AsperGenius). Read More

    Twelve-month clinical outcomes of 206 patients with chronic pulmonary aspergillosis.
    PLoS One 2018 10;13(4):e0193732. Epub 2018 Apr 10.
    The National Aspergillosis Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
    There is a paucity of evidence surrounding the optimal antifungal therapy for use in chronic pulmonary aspergillosis (CPA) and the duration of therapy remains unclear. We retrospectively evaluated treatment outcomes, including change in quality of life scores (St George's Respiratory Questionnaire (QoL)), weight and Aspergillus IgG at 6 and 12 months following initiation of therapy in a cohort of 206 CPA patients referred to the UK National Aspergillosis Centre (NAC), Manchester between April 2013 and March 2015. One hundred and forty-two patients (69%) were azole naïve at presentation and 105 (74%) (Group A) were commenced on itraconazole, 27 (19%) on voriconazole, and 10 (7%) were not treated medically. Read More

    Diagnostic Approaches for Invasive Aspergillosis-Specific Considerations in the Pediatric Population.
    Front Microbiol 2018 26;9:518. Epub 2018 Mar 26.
    Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, Frankfurt, Germany.
    Invasive aspergillosis (IA) is a major cause of morbidity and mortality in children with hematological malignancies and those undergoing hematopoietic stem cell transplantation. Similar to immunocompromised adults, clinical signs, and symptoms of IA are unspecific in the pediatric patient population. As early diagnosis and prompt treatment of IA is associated with better outcome, imaging and non-invasive antigen-based such as galactomannan or ß-D-glucan and molecular biomarkers in peripheral blood may facilitate institution and choice of antifungal compounds and guide duration of therapy. Read More

    polymorphisms, an insight on their significance.
    Antimicrob Agents Chemother 2018 Apr 9. Epub 2018 Apr 9.
    Mycology Reference Laboratory, National Centre for Microbiology. Instituto de Salud Carlos III (ISCIII). Majadahonda, Madrid, Spain.
    Triazole antifungal compounds are the first treatment choice for invasive aspergillosis. However, in the last decade azole resistance has increased notoriously. The main resistance mechanisms are well-defined and mostly related to point mutations of the azole target, 14-α sterol demethylase (), with or without tandem repeat integrations in the promoter. Read More

    A novel polyaminocarboxylate compound to treat murine pulmonary aspergillosis by interfering with zinc metabolism.
    Antimicrob Agents Chemother 2018 Apr 9. Epub 2018 Apr 9.
    Institut Pasteur, Cytokines & Inflammation Unit Instituto de Biología Funcional y Genómica (IBFG). Departamento de Microbiología y Genética. Universidad de Salamanca, 37007 Salamanca, Spain.
    can cause pulmonary aspergillosis in immunocompromised patients and is associated with a high mortality rate due to the lack of reliable treatment options. This opportunistic pathogen requires zinc in order to grow and cause disease. Novel compounds that interfere with fungal zinc metabolism may therefore be of therapeutic interest. Read More

    Animal Models of Aspergillosis.
    Comp Med 2019 Mar;68(2):109-123
    Department of Pathology and Laboratory Medicine, Division of Comparative Pathology, Miller School of Medicine, University of Miami, Miami, Florida;, Email:
    Aspergillosis is an airborne fungal disease caused by Aspergillus spp., a group of ubiquitous molds. This disease causes high morbidity and mortality in both humans and animals. Read More

    Clinical efficacy of sequential therapy with voriconazole on COPD patients in acute phase with pulmonary aspergillosis and effects on cytokines and pulmonary functions.
    Eur Rev Med Pharmacol Sci 2018 Mar;22(6):1837-1842
    Department of Respiratory Medicine, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
    Objective: To explore the clinical efficacy of sequential therapy with voriconazole on chronic obstructive pulmonary disease (COPD) patients in acute phase with pulmonary aspergillosis and its effects on cytokines and pulmonary functions.

    Patients And Methods: A total of 110 COPD patients in acute phase with pulmonary aspergillosis who were admitted to the hospital between February 2015 and November 2016 were enrolled. We divided them randomly into two groups, i. Read More

    Pulmonary Hydatid Disease with Aspergillosis - An Unusual Association in an Immunocompetent Host.
    Turk Patoloji Derg 2018 Apr 9. Epub 2018 Apr 9.
    Department of Pathology, Dayanand Medical College and Hospital, LUDHIANA, INDIA.
    Echinococcosis is a common cause of pulmonary cavities. Aspergillus fumigatus, a saprophytic fungus, can colonise pulmonary cavities caused by tuberculosis, sarcoidosis, echinococcosis, bronchiectasis and neoplasms. Infection by Aspergillus is often seen in immunosuppressed cases. Read More

    Galactomannan Antigen Test for Early Diagnosis of Invasive Aspergillus Infection in Pediatric Febrile Neutropenia.
    Indian Pediatr 2018 03;55(3):257-258
    Department of Pediatrics, AIIMS, New Delhi, India.
    Invasive aspergillosis is a major concern in neutropenic patients. We studied the utility of Galactomannan antigen detection test in serum using ELISA technique for early detection of invasive aspergillosis. Diagnostic accuracy of Galactomannan index (GMI) test was maximum at a cut-off of > 1. Read More

    Invasive fungal infection in immunocompetent trauma patients - A case series.
    J Clin Orthop Trauma 2018 Mar 16;9(Suppl 1):S10-S14. Epub 2017 Oct 16.
    Department of Orthopaedics, Sri Ramachandra University, India.
    Zygomycosis is the third leading cause of invasive fungal infection after candidiasis and aspergillosis. Although zygomycosis mostly affects immunocompromised individuals trauma may potentiate infection in immunocompetent individuals. The mortality rate of Zygomycosis is around 50% due to angioinvasion. Read More

    Invasive fungal infections associated with prior respiratory viral infections in immunocompromised hosts.
    Infection 2018 Apr 7. Epub 2018 Apr 7.
    Division of Infectious Diseases, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
    Background: Increased risk of invasive pulmonary aspergillosis after influenza infection has been reported; however data are limited.

    Purpose: To describe Invasive fungal infections (IFI) associated with preceding respiratory viral infection at a large referral center.

    Methods: We reviewed all IFI cases among patients with positive influenza and/or RSV nasopharyngeal/lower respiratory tract PCR from October 2015 to December 2016. Read More

    Macular toxicity and blind spot enlargement during a treatment by voriconazole: A case report.
    Eur J Ophthalmol 2018 Mar 1:1120672117750051. Epub 2018 Mar 1.
    1 Department of Ophthalmology, Hôpital d'Instruction des Armées Desgenettes, Lyon, France.
    Purpose: To report a case of macular toxicity and blind spot enlargement during voriconazole treatment.

    Methods: This is a case report.

    Results: We describe a 77-year-old man treated by voriconazole for pulmonary aspergillosis, who complained of visual disorders such as dyschromatopsia and visual hallucinations 3 days after voriconazole initiation. Read More

    Invasive pulmonary aspergillosis is associated with adverse clinical outcomes in critically ill patients receiving veno-venous extracorporeal membrane oxygenation.
    Eur J Clin Microbiol Infect Dis 2018 Apr 6. Epub 2018 Apr 6.
    Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
    To identify the incidence, risk factors and impact on long-term survival of invasive pulmonary aspergillosis (IPA) and Aspergillus colonisation in patients receiving vv-extracorporeal membrane oxygenation (ECMO). A retrospective evaluation was performed of patients receiving vv-ECMO at a tertiary hospital in Manchester (UK) between January 2012 and December 2016. Data collected included epidemiological data, microbiological cultures, radiographic findings and outcomes. Read More

    Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response.
    Thorax 2018 Apr 5. Epub 2018 Apr 5.
    Department of Internal Medicine, Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea.
    Background: Respiratory fungal exposure is known to be associated with severe allergic lung inflammation. Airway epithelium is an essential controller of allergic inflammation. An innate immune recognition receptor, nucleotide-binding domain, leucine-rich-containing family, pyrin-domain-containing-3 (NLRP3) inflammasome, and phosphoinositide 3 kinase (PI3K)-δ in airway epithelium are involved in various inflammatory processes. Read More

    Molecular Detection of Azole-Resistant in Clinical Samples.
    Front Microbiol 2018 21;9:515. Epub 2018 Mar 21.
    Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands.
    diseases are often caused by . Azoles are the mainstay of therapy, but the management of aspergillosis is hampered by the emergence of azole resistance. Rapid detection of azole resistance might benefit treatment outcome by early treatment modifications. Read More

    Serum galactomannan for diagnosing invasive aspergillosis in pediatric patients: A meta-analysis.
    Microb Pathog 2018 Mar 31;118:347-356. Epub 2018 Mar 31.
    Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. Electronic address:
    Background: The serum galactomannan (GM) assay is used to diagnose invasive aspergillosis (IA). We conducted a systematic review and analysis to estimate the overall accuracy of the serum GM test for diagnosing pediatric IA.

    Method: A systematic literature review was conducted of all relevant studies published in PubMed and EMbase databases up to March 10, 2017. Read More

    Serodiagnosis of aspergillosis in falcons (Falco spp.) by Afmp1p-based enzyme-linked immunosorbent assay.
    Mycoses 2018 Apr 3. Epub 2018 Apr 3.
    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
    Aspergillosis in falcons may be associated with high mortality and difficulties in clinical and laboratory diagnosis. We previously cloned an immunogenic protein, Afmp1p, in Aspergillus fumigatus and showed that anti-Afmp1p antibodies were present in human patients with A. fumigatus infections. Read More

    Susceptibility of A. fumigatus specific T-cell assays to pre-analytic blood storage and PBMC cryopreservation greatly depends on readout platform and analytes.
    Mycoses 2018 Apr 3. Epub 2018 Apr 3.
    University Hospital of Wuerzburg, Department of Internal Medicine II Division of Infectious Diseases, Oberduerrbacher Str. 6, 97080, Wuerzburg, Germany.
    Mould specific T-cells detectable by flow cytometry or ELISPOT were proposed as a novel biomarker in invasive aspergillosis. To define protocols facilitating sample shipment and longitudinal analysis, this study evaluated the susceptibility of different functional assays for A. fumigatus specific T-cell quantification and characterisation to pre-analytic delays. Read More

    SCY-078, a Novel Oral Glucan Synthase Inhibitor, for the Treatment of Invasive Aspergillosis: Evaluation of Antifungal Activity Singly and in Combination.
    Antimicrob Agents Chemother 2018 Apr 2. Epub 2018 Apr 2.
    Scynexis, Inc., Jersey City, NJ.
    Invasive aspergillosis remains a major cause of death among the immunocompromised population and those receiving long-term immunosuppressive therapy. In light of increased azole resistance, variable outcomes with existing echinocandin mono and combination therapy, and persistent high mortality rates, new antifungal agents for the treatment of invasive aspergillosis are clearly needed.SCY-078 is the first in class triterpenoid antifungal, a novel class of glucan synthase inhibitors, with broad and activity against a broad spectrum of and testing of clinical strains of and non- strains showed potent fungistatic activity of SCY-078 (minimum effective concentration, MEC = 0. Read More

    Aspergillus-specific antibodies - Targets and applications.
    Biotechnol Adv 2018 Mar 30. Epub 2018 Mar 30.
    Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Forckenbeckstrasse 6, 52074 Aachen, Germany.
    Aspergillus is a fungal genus comprising several hundred species, many of which can damage the health of plants, animals and humans by direct infection and/or due to the production of toxic secondary metabolites known as mycotoxins. Aspergillus-specific antibodies have been generated against polypeptides, polysaccharides and secondary metabolites found in the cell wall or secretions, and these can be used to detect and monitor infections or to quantify mycotoxin contamination in food and feed. However, most Aspergillus-specific antibodies are generated against heterogeneous antigen preparations and the specific target remains unknown. Read More

    Pseudomembranous Invasive Tracheobronchial Aspergillosis with Fulminant Hepatitis and Hemophagocytic Syndrome.
    Intern Med 2018 Mar 30. Epub 2018 Mar 30.
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan.
    Invasive tracheobronchial aspergillosis (ITBA), a rare form of invasive pulmonary Aspergillus infection (IPA), is predominantly confined to the tracheobronchial tree. We herein report a case of ITBA with severe necrotic pseudomembrane in a 57-year-old woman with fulminant hepatitis and hemophagocytic syndrome. Bronchoscopic findings revealed a widespread pseudomembranous formation of the trachea and bronchi. Read More

    Successful Long-term Management of Two Cases of Moderate Hemoptysis Due to Chronic Cavitary Pulmonary Aspergillosis with Bronchial Occlusion Using Silicone Spigots.
    Intern Med 2018 Mar 30. Epub 2018 Mar 30.
    Department of Respiratory Medicine, Japanese Red Cross Okayama Hospital, Japan.
    Chronic pulmonary aspergillosis is a major cause of life-threatening hemoptysis. In symptomatic patients with simple aspergillomas, surgery is the main therapeutic method for preventing or treating life-threatening hemoptysis. However, the risks of both death and complications are higher in chronic cavitary pulmonary aspergillosis than in simple aspergilloma. Read More

    [Post-traumatic pulmonary aspergilloma].
    Rev Mal Respir 2018 Mar 27. Epub 2018 Mar 27.
    CS10217, clinique universitaire de pédiatrie, CHU de Grenoble-Alpes, hôpital Couple-Enfants, 38043 Grenoble cedex 9, France; Inserm 1209, institut pour l'avancée des biosciences, 38042 Grenoble cedex 9, France. Electronic address:
    Introduction: Aspergillomas occur due to colonization of a pre-existing pulmonary, bronchial or pleural cavity by Aspergillus spp. Often asymptomatic, this pathology can reveal itself by recurrent haemoptysis or when bacterial superinfections occur. Aspergillomas occurring in post-traumatic cavities are rare and their management is poorly codified. Read More

    Treatment of canine sinonasal aspergillosis with clotrimazole infusion in patients with cribriform plate lysis.
    J Small Anim Pract 2018 Mar 30. Epub 2018 Mar 30.
    Department of Clinical Science, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
    Objective: To describe the treatment of sinonasal aspergillosis with topical 1% clotrimazole solution in dogs with cribriform plate lysis.

    Materials And Methods: This retrospective study includes data retrieval from medical records of dogs with sinonasal aspergillosis and cribriform plate lysis that underwent topical treatment with 1% clotrimazole solution.

    Results: Five dogs with sinonasal aspergillosis, cribriform plate lysis diagnosed on CT scans, and normal neurologic examinations were treated with a single (n=3) or multiple (n=2) infusions of clotrimazole solution. Read More

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