19,194 results match your criteria Aspergillosis


Characterization of crystal structure and key residues of Aspergillus fumigatus nucleoside diphosphate kinase.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Center for Disease Control and Prevention of Chinese PLA, Beijing, 100071, China. Electronic address:

Aspergillus fumigatus is a major pathogen of invasive pulmonary aspergillosis with high mortality rate. The nucleoside diphosphate kinase of A. fumigatus, AfNDK (also called SwoH) is essential for its viability, however, its structural characteristic was unknown. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.126DOI Listing
February 2019

Successful treatment with omalizumab of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis: case reports and literature review.

J Allergy Clin Immunol Pract 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

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http://dx.doi.org/10.1016/j.jaip.2019.01.056DOI Listing
February 2019

Epidemiology and clinical outcomes of invasive mould infections in Indian intensive care units (FISF study).

J Crit Care 2019 Feb 5;51:64-70. Epub 2019 Feb 5.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background And Aim: Due to limited data on invasive mould infections (IMIs) in the intensive care units (ICUs) of developing countries, we ascertain epidemiology and management of IMIs at 11 ICUs across India.

Methods: Consecutive patients with proven or probable/putative IMIs were enrolled during the study period. Subjects were categorized into classical (neutropenia, malignancy, transplant recipients on immunosuppression) and non-classical (chronic obstructive pulmonary disease, diabetes, liver disease and glucocorticoids) risk groups. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.005DOI Listing
February 2019

Reinvestigation of carbohydrate specificity of EB-A2 monoclonal antibody used in the immune detection of galactomannan.

Heliyon 2019 Jan 31;5(1):e01173. Epub 2019 Jan 31.

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.

Great progresses have been made in the recent years in the detection of circulating galactofuranose-bearing molecules for the diagnosis of aspergillosis. However, the test used in the clinical practice is hampered by the occurrence of false positives. A glycoarray with dozens of oligosaccharides structurally related to the galactomannan has allowed us to reinvestigate the carbohydrate specificity of the EB-A2 monoclonal antibody used in the Platelia Aspergillus sandwich immune assay. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360342PMC
January 2019

Multicenter Evaluation of a Novel Immunochromatographic Test for Anti-aspergillus IgG Detection.

Front Cell Infect Microbiol 2019 31;9:12. Epub 2019 Jan 31.

Aix-Marseille Université, APHM, IRD, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France.

sp. fungi cause various diseases in both immunocompetent and immunocompromised patients. The most frequent disorders include chronic pulmonary aspergillosis (CPA), a life-threatening disease that affects at least 3 million people worldwide, and allergic bronchopulmonary aspergillosis (ABPA), which affects approximately 4. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365447PMC
January 2019

Allergic bronchopulmonary aspergillosis presumably unmasked by PD-1 inhibition.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Pulmonary and Critical Care, Tower Health System, West Reading, Pennsylvania, USA.

Programmed cell death-1 (PD-1) inhibitors stimulate immune recognition of tumour cells in cancer patients, but have significant autoimmune side effects including pneumonitis. We report the case of a patient with asthma and mild eosinophilia who developed unusual pulmonary side effect of bronchiectasis, severe eosinophilia (absolute eosinophil count: 3200 c/mm) and elevated IgE levels (7050 IU/mL; normal: <164 IU/mL) 4 months into therapy with the PD-1 inhibitor pembrolizumab. Aspergillus fumigatus IgG was elevated at 15. Read More

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http://dx.doi.org/10.1136/bcr-2018-227814DOI Listing
February 2019

Subacute invasive aspergillosis in a patient with cystic fibrosis.

Authors:
E Padrão A Amorim

Pulmonology 2019 Feb 11. Epub 2019 Feb 11.

Pulmonology Department, Centro Hospitalar de São João, Porto, Portugal; Faculty of Medicine, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1016/j.pulmoe.2019.01.003DOI Listing
February 2019

CT evaluation of hyperattenuating mucus to diagnose allergic bronchopulmonary aspergillosis in the special condition of cystic fibrosis.

J Cyst Fibros 2019 Feb 12. Epub 2019 Feb 12.

CHU de Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire, Unité de Pneumologie pédiatrique, Service de Parasitologie-Mycologie, CIC 1401, F-33600 Pessac, France; Univ. Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, CIC 1401, F-33000 Bordeaux, France; Inserm, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, CIC 1401, F-33000 Bordeaux, France. Electronic address:

Background: Mucus plugging (MP), central bronchiectasis (CB), and consolidation/atelectasia (CA) are conventional CT signs to diagnose allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF). Hyperattenuating mucus (HAM) has recently been described and may improve diagnostic accuracy. The goal of our study was to compare HAM versus conventional CT signs to diagnose ABPA in CF. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.02.002DOI Listing
February 2019

Impairing Fluoride Export of Aspergillus fumigatus Mitigates Its Voriconazole Resistance.

Int J Antimicrob Agents 2019 Feb 11. Epub 2019 Feb 11.

Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany. Electronic address:

Fungi have evolved specific export activities to balance intracellular levels of the toxic ion fluoride, while the first-line antimycotic voriconazole contains fluorine. We aimed to explore whether impaired fluoride export might result in altered susceptibilities of the human pathogenic mould Aspergillus fumigatus towards this antifungal compound. Functional characterisation of the putative fluoride exporter in A. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.02.003DOI Listing
February 2019

Invasive fungal infection in crtically ill patients: hurdles and next challenges.

J Chemother 2019 Feb 14:1-10. Epub 2019 Feb 14.

g Intensive Care Unit , Hospital Universitario Dr. Peset , Valencia , Spain.

A narrative review from a multidisciplinary task force of experts in critical care medicine and clinical mycology was carried out. The multi drug-resistant species Candida auris has emerged simultaneously on several continents, causing hospital outbreaks, especially in critically ill patients. Although there are not enough data to support the routine use of continuous antibiotic prophylaxis in patients subjected to extracorporeal membrane oxygenator, a clear increase of invasive fungal infection (IFI) has been described with the use of this device. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1557799DOI Listing
February 2019
2 Reads

Dectin-1-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy.

mSphere 2019 Feb 13;4(1). Epub 2019 Feb 13.

Department of Genetics, University of Georgia, Athens, Georgia, USA

species cause pulmonary invasive aspergillosis resulting in nearly 100,000 deaths each year. Patients at the greatest risk of developing life-threatening aspergillosis have weakened immune systems and/or various lung disorders. Patients are treated with antifungals such as amphotericin B (AmB), caspofungin acetate, or triazoles (itraconazole, voriconazole, etc. Read More

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http://msphere.asm.org/lookup/doi/10.1128/mSphere.00025-19
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http://dx.doi.org/10.1128/mSphere.00025-19DOI Listing
February 2019
3 Reads

Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients.

Med Mycol 2019 Feb 13. Epub 2019 Feb 13.

Radboud university medical center, Department of Pharmacy and Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Voriconazole is the mainstay of treatment for invasive aspergillosis in immunocompromised pediatric patients. Although Therapeutic Drug Monitoring (TDM) of voriconazole is recommended, it remains unknown if TDM-based dose adaptations result in target attainment. Patients <19 years from two pediatric hematologic-oncology wards were retrospectively identified based on unexplained high voriconazole trough concentrations (Cmin > 6 mg/l). Read More

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http://dx.doi.org/10.1093/mmy/myz006DOI Listing
February 2019

Two KTR Mannosyltransferases Are Responsible for the Biosynthesis of Cell Wall Mannans and Control Polarized Growth in .

MBio 2019 Feb 12;10(1). Epub 2019 Feb 12.

Aspergillus Unit, Institut Pasteur, Paris, France

Fungal cell wall mannans are complex carbohydrate polysaccharides with different structures in yeasts and molds. In contrast to yeasts, their biosynthetic pathway has been poorly investigated in filamentous fungi. In , the major mannan structure is a galactomannan that is cross-linked to the β-1,3-glucan-chitin cell wall core. Read More

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http://dx.doi.org/10.1128/mBio.02647-18DOI Listing
February 2019

Surgical management of pulmonary aspergillosis in pediatric population.

J Pediatr Surg 2019 Jan 11. Epub 2019 Jan 11.

Introduction: Aspergillosis is an invasive infection that affects mainly immunocompromised patients, and the lung is the most common site of infection. We reviewed our experience with the surgical management of pulmonary aspergillosis (PA) in pediatric population at a tertiary care institution.

Methods: A retrospective chart review was conducted for pediatric patients (<16 years) who were managed for PA over the period from January 2001 to December 2016. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.003DOI Listing
January 2019
1 Read

Invasive Aspergillosis in Pediatric Leukemia Patients: Prevention and Treatment.

J Fungi (Basel) 2019 Feb 11;5(1). Epub 2019 Feb 11.

Infectious Diseases Unit, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.

The purpose of this article is to review and update the strategies for prevention and treatment of invasive aspergillosis (IA) in pediatric patients with leukemia and in patients with hematopoietic stem cell transplantation. The major risk factors associated with IA will be described since their recognition constitutes the first step of prevention. The latter is further analyzed into chemoprophylaxis and non-pharmacologic approaches. Read More

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http://dx.doi.org/10.3390/jof5010014DOI Listing
February 2019

Use of Aspergillus fumigatus real-time PCR in bronchoalveolar lavage samples (BAL) for diagnosis of invasive aspergillosis, including azole-resistant cases, in high risk haematology patients: the need for a combined use with galactomannan.

Med Mycol 2019 Feb 7. Epub 2019 Feb 7.

Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Diagnosis of invasive aspergillosis (IA) is challenging, particularly in high-risk patients with lung lesions other than typical according to 2008-EORTC/MSG criteria. Even if microbiology is positive, they still remain unclassified according to 2008-EORTC/MSG. Quantitative polymerase chain reaction (qPCR) provides new mycological documentation of IA. Read More

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http://dx.doi.org/10.1093/mmy/myz002DOI Listing
February 2019

Isavuconazole brain penetration in cerebral aspergillosis.

J Antimicrob Chemother 2019 Feb 11. Epub 2019 Feb 11.

Service and Laboratory of Clinical Pharmacology, University Hospital, Lausanne, Switzerland.

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http://dx.doi.org/10.1093/jac/dkz050DOI Listing
February 2019
1 Read

An unusual case of cardiac aspergillosis.

Eur Heart J 2019 Feb 8. Epub 2019 Feb 8.

Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy.

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http://dx.doi.org/10.1093/eurheartj/ehz026DOI Listing
February 2019

Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B Formation through Inhibition of Leukotriene A Hydrolase.

Cell Chem Biol 2019 Jan 17. Epub 2019 Jan 17.

Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany. Electronic address:

The epidithiodioxopiperazine gliotoxin is a virulence factor of Aspergillus fumigatus, the most important airborne fungal pathogen of humans. Gliotoxin suppresses innate immunity in invasive aspergillosis, particularly by compromising neutrophils, but the underlying molecular mechanisms remain elusive. Neutrophils are the first responders among innate immune cells recruited to sites of infection by the chemoattractant leukotriene (LT)B that is biosynthesized by 5-lipoxygenase and LTA hydrolase (LTAH). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193000
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http://dx.doi.org/10.1016/j.chembiol.2019.01.001DOI Listing
January 2019
3 Reads

Cost-effectiveness analysis of isavuconazole versus voriconazole for the treatment of patients with possible invasive aspergillosis in Sweden.

BMC Infect Dis 2019 Feb 11;19(1):134. Epub 2019 Feb 11.

Department of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden.

Background: Voriconazole is well established as standard treatment for invasive aspergillosis (IA). In 2017, isavuconazole, a new antifungal from the azole class, with a broader pathogen spectrum, was introduced in Sweden. A model has therefore been developed to compare the cost-effectiveness of isavuconazole and voriconazole in the treatment of possible IA in adults in Sweden. Read More

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http://dx.doi.org/10.1186/s12879-019-3683-2DOI Listing
February 2019

Pulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case report.

BMC Pulm Med 2019 Feb 8;19(1):34. Epub 2019 Feb 8.

Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Background: Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder defined by high serum immunoglobulin E titers that is associated with recurrent respiratory infections, formation of pneumoatoceles, recurrent skin abscesses, and characteristic dental and skeletal abnormalities.

Case Presentation: We report a case of a 56-year-old male with a history of HIES, cavitary mycetomas, and allergic bronchopulmonary aspergillosis who presented with recurrent massive hemoptysis. Bronchial artery angiography and bronchoscopy failed to identify active hemorrhage, and two embolizations of the bronchial artery did not resolve the bleeding. Read More

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http://dx.doi.org/10.1186/s12890-019-0797-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368789PMC
February 2019
1 Read

Aspergillus species collected from environmental air samples in Portugal- molecular identification, antifungal susceptibility and sequencing of cyp51A gene on A. fumigatus sensu stricto itraconazole-resistant.

J Appl Microbiol 2019 Feb 8. Epub 2019 Feb 8.

Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy of University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

Aims: Aspergillus spp. are ubiquitous saprophytic fungi and their conidia easily inhaled. This is particularly important in immunocompromised patients, more susceptible to developing invasive aspergillosis. Read More

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http://dx.doi.org/10.1111/jam.14217DOI Listing
February 2019
1 Read

Two cases of infection in immunocompromised patients in the Netherlands.

Med Mycol Case Rep 2019 Jun 14;24:5-8. Epub 2019 Jan 14.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.

We report two cases of infection in the Netherlands. Both patients were immunocompromised and had pulmonary symptoms. The first patient died due to a pulmonary infection with , concomitant listeriosis, sepsis and invasive pulmonary aspergillosis. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357787PMC
June 2019
2 Reads

Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition.

Int J Pharm 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China. Electronic address:

Systemic administration of antifungal agents for the treatment of pulmonary aspergillosis is limited by the poor lung deposition and severe adverse effects. In contrast, pulmonary delivery allows a higher amount of drug to be delivered directly to the infection site and therefore a lower dose is required. This study aimed to develop porous and inhalable voriconazole dry powder with good lung deposition by spray freeze drying (SFD), using tert-butyl alcohol (TBA) as a co-solvent. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.057DOI Listing
February 2019
5 Reads

Unravelling species boundaries in the complex (section ): opportunistic human and animal pathogens capable of interspecific hybridization.

Persoonia 2018 Dec 21;41:142-174. Epub 2018 Jun 21.

Laboratory of Fungal Genetics and Metabolism, Institute of Microbiology of the CAS, v.v.i, Vídeňská 1083, 142 20 Prague 4, Czech Republic.

Although is the major agent of invasive aspergillosis, an increasing number of infections are caused by its cryptic species, especially and the species complex (AVSC). Their identification is clinically relevant because of antifungal drug resistance and refractory infections. Species boundaries in the AVSC are unresolved since most species have uniform morphology and produce interspecific hybrids . Read More

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http://dx.doi.org/10.3767/persoonia.2018.41.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344812PMC
December 2018

Endocytic Markers Associated with the Internalization and Processing of Conidia by BEAS-2B Cells.

mSphere 2019 Feb 6;4(1). Epub 2019 Feb 6.

Biocomplexity Institute of Virginia Tech, Blacksburg, Virginia, USA

is a ubiquitous mold that produces small airborne conidia capable of traversing deep into the respiratory system. Recognition, processing, and clearance of conidia by bronchial airway epithelial cells are thought to be relevant to host defense and immune signaling. Using z-stack confocal microscopy, we observed that only 10 to 20% of adherent conidia from the AF293 clinical isolate are internalized by BEAS-2B cells 6 h postchallenge and not prior. Read More

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http://msphere.asm.org/lookup/doi/10.1128/mSphere.00663-18
Publisher Site
http://dx.doi.org/10.1128/mSphere.00663-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365614PMC
February 2019
4 Reads

[Coexistence of Pulmonary Aspergillosis and Hydatidosis. Case report].

Rev Peru Med Exp Salud Publica 2018 Oct-Dec;35(4):689-694

Hospital Edgardo Rebagliati Martins, EsSalud. Lima, Perú.

Hydatidosis is a zoonosis caused by the parasite Echinococcus granulosus and Peru is an endemic zone for this infection. We present the case of a 33-year old woman from the region of Ica who, during gestation, was diagnosed with liver and pulmonary hydatidosis. After gestation was terminated, she was referred with thoracic drainage tube, dyspnea, and thoracic pain in right hemithorax, with progressive course and tomographic image of thorax showing right posterior basal pulmonary cyst. Read More

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http://dx.doi.org/10.17843/rpmesp.2018.354.3437DOI Listing
January 2018
1 Read

[Evaluation of the lateral flow Aspergillus assay for the diagnosis of invasive aspergillosis, experience in a university hospital].

Rev Chilena Infectol 2018 ;35(5):574-579

Departamento de Enfermedades Infecciosas del adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: The incidence of invasive aspergillosis is increasing. Its diagnosis is based on clinical and microbiological criteria which include the determination of serological markers such as galactomannan. Recently, the Aspergillus lateral flow device, an inmunocromatograph assay has been described for its diagnosis. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500574DOI Listing
January 2018
1 Read

[Update in the diagnostic and therapeutic approach of invasive aspergillosis in adult population].

Rev Chilena Infectol 2018 ;35(5):531-544

Departamento de Enfermedades Infecciosas del Adulto, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

The invasive fungal disease produced by Aspergillus spp., is the infection by filamentous fungi most frequently reported among immunocompromised individuals and responsible for a very high mortality in this group of patients. In recent years, important advances have been made both from the diagnostic and therapeutic point of view. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500531DOI Listing
January 2018
1 Read

A novel diagnosis scoring model to predict invasive pulmonary aspergillosis in the intensive care unit.

Saudi Med J 2019 Feb;40(2):140-146

Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. E-mail.

Objectives: To improve the quality of invasive pulmonary aspergillosis (IPA) management for intensive care unit (ICU) patients using a practical diagnostic scoring model.

Methods: This nested case-control study aimed to determine the incidence of IPA in 405 ICU patients, between July 2012 and June 2014, at 6 hospitals in Jakarta, Indonesia. Phenotypic identifications and galactomannan (GM) tests of sera and lung excreta were performed in mycology laboratory, Parasitology Department, Faculty of Medicine, Universitas Indonesia in Jakarta, Indonesia. Read More

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http://dx.doi.org/10.15537/smj.2019.2.22940DOI Listing
February 2019
2 Reads

Aspergillosis in immunocompromised patients with haematological malignancies.

J BUON 2018 Dec;23(7):7-10

ENT Department, Medical School, University of Thessaly, Larissa, Greece.

Aspergillosis, which is saprophytic in nature, is known to cause massive destruction of paranasal sinuses in immunocompromised hosts, but in immunocompetent individuals invasive aspergillosis is rare. Diagnosis is posed from history, physical examination including anterior and posterior rhinoscopy, endoscopy of the nose and paranasal sinuses, radiological findings (CT and/or MRI), fungus cultures and histopathological examination. Non-specific presenting symptoms provide time for infection to extent from sinuses to vital surroundings such as bony, vascular and central nervous system structures, thereby increasing morbidity and mortality. Read More

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December 2018
1 Read

Outcomes of patients with invasive fusariosis who undergo further immunosuppressive treatments, is there a role for secondary prophylaxis?

Mycoses 2019 Feb 5. Epub 2019 Feb 5.

Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA, USA.

Background: Patients treated for invasive aspergillosis may relapse during subsequent periods of immunosuppression and should receive secondary prophylaxis. Little is known about the frequency of relapse and practices of secondary prophylaxis for invasive fusariosis (IF).

Objectives: Evaluate practices of secondary prophylaxis and the frequency of relapse in patients who survived IF and were exposed to subsequent periods of immunosuppression. Read More

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http://dx.doi.org/10.1111/myc.12901DOI Listing
February 2019
1 Read

Correction: Combination Antifungal Therapy for Invasive Aspergillosis.

Authors:

Ann Intern Med 2019 Feb;170(3):220

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http://dx.doi.org/10.7326/L18-0712DOI Listing
February 2019
1 Read

Invasive aspergillosis manifesting as retinal necrosis in a patient treated with ruxolitinib.

Arch Soc Esp Oftalmol 2019 Jan 31. Epub 2019 Jan 31.

Sección de Retina Médica, Departamento de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.

A 30 year-old man with acute myeloblastic leukaemia and secondary myelodysplastic syndrome developed graft-versus-host disease. The patient was treated with ruxolitinib. After being treated for 3 months with ruxolitinib, an inhibitor of Janus kinase, he developed Aspergillus retinal necrosis resistant to common treatment. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.12.006DOI Listing
January 2019
1 Read

[Invasive pulmonary aspergillosis in an immunocompetent patient presenting with influenza infection].

Authors:
P Saint-Léger

Med Mal Infect 2019 Jan 29. Epub 2019 Jan 29.

Service de réanimation polyvalente, centre hospitalier de Valenciennes, avenue Desandrouin, 59322 Valenciennes cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.medmal.2019.01.004DOI Listing
January 2019
1 Read

Prevalence of allergic bronchopulmonary aspergillosis among patients with severe bronchial asthma in a tertiary care hospital in Northern India.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):111-113

Department of Microbiology, Government Medical College and Hospital, Chandigarh, India.

Introduction: The link between fungi and asthma has been known for centuries. About one-third to one-half of severe asthmatics has history of atopic sensitization to filamentous fungi, most predominantly to Aspergillus fumigatus. Allergic bronchopulmonary aspergillosis (ABPA) is the one of the most documented fungal presentations among patients with asthma. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_205_18DOI Listing
February 2019
1 Read

Chronic pulmonary aspergillosis commonly complicates treated pulmonary tuberculosis with residual cavitation.

Eur Respir J 2019 Jan 31. Epub 2019 Jan 31.

Division of Infection, Immunity & Respiratory Medicine, Faculty of Biology, Medicine & Health, The University of Manchester, Manchester Academic Health Science Centre, UK.

Chronic pulmonary aspergillosis (CPA) complicates treated pulmonary tuberculosis, with high 5-year mortality. We measured CPA prevalence in this group.398 Ugandans with treated pulmonary tuberculosis underwent clinical assessment, chest X-ray and -specific IgG measurement. Read More

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http://dx.doi.org/10.1183/13993003.01184-2018DOI Listing
January 2019
2 Reads

Case series of allergic bronchopulmonary aspergillosis treated successfully and safely with long-term mepolizumab.

Allergol Int 2019 Jan 28. Epub 2019 Jan 28.

Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2018.12.008DOI Listing
January 2019
2 Reads

[Advances in the treatment of allergic bronchopulmonary aspergillosis].

Zhonghua Nei Ke Za Zhi 2019 Feb;58(2):150-153

Department of Respiratory Internal Medicine, Peking University International Hospital, Beijing 102200, China.

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.02.014DOI Listing
February 2019
1 Read

Concurrent cerebral aspergillosis and abdominal mucormycosis during Ibrutinib therapy for chronic lymphocytic leukemia.

Clin Microbiol Infect 2019 Jan 28. Epub 2019 Jan 28.

Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants malades Hospital, AP-HP, IHU Imagine, Paris, France; Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Mycologie Moléculaire, UMR 2000, Paris, France.

Peri et al reported a case of invasive aspergillosis with primary pulmonary involvement followed by central nervous system (CNS) involvement in a patient treated for chronic lymphocytic leukemia (CLL) with ibrutinib. In addition to their work, we describe a case of primary CNS aspergillosis involvement and abdominal mucormycosis in a patient treated with ibrutinib. Emerging fungal syndrome in patients with CLL receiving ibrutinib justifies the need for an exhaustive work-up for extrapulmonary involvement and invasive diagnosing procedures regarding the risk of dissemination and fungal co-infection. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.016DOI Listing
January 2019
1 Read

Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Respiratory Division of Medicine, University College London, London, UK.

We describe three cases of pulmonary aspergillosis (PA) in three patients without traditional risk factors for invasive aspergillosis infection, such as prolonged neutropenia or high dose systemic corticosteroid therapy. All three patients developed PA while taking tyrosine kinase inhibitors (TKI) and sustained greater clinical improvement once TKI were withdrawn. Our case series supports the theory TKI treatment can increase susceptibility to PA without causing neutropenia. Read More

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http://dx.doi.org/10.1136/bcr-2018-226121DOI Listing
January 2019
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SH3-class Ras guanine nucleotide exchange factors are essential for Aspergillus fumigatus invasive growth.

Cell Microbiol 2019 Jan 30:e13013. Epub 2019 Jan 30.

Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Proper hyphal morphogenesis is essential for the establishment and progression of invasive disease caused by filamentous fungi. In the human pathogen Aspergillus fumigatus, signalling cascades driven by Ras and Ras-like proteins orchestrate a wide variety of cellular processes required for hyphal growth. For activation, these proteins require interactions with Ras-subfamily-specific guanine nucleotide exchange factors (RasGEFs). Read More

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http://dx.doi.org/10.1111/cmi.13013DOI Listing
January 2019
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Exacerbation of chronic pulmonary aspergillosis was associated with a high rebleeding rate after bronchial artery embolization.

Respir Investig 2019 Jan 25. Epub 2019 Jan 25.

Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, Tokyo 204-8585, Japan. Electronic address:

Background: Hemoptysis is a common symptom associated with chronic pulmonary aspergillosis (CPA). While surgery is the primary choice to manage hemoptysis, it is often avoided because patients with CPA are more likely to have complications such as respiratory insufficiency and low pulmonary function. Bronchial artery embolization (BAE) may be considered one of the treatments of massive and persistent hemoptysis for such patients. Read More

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http://dx.doi.org/10.1016/j.resinv.2018.12.009DOI Listing
January 2019
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Evaluation of 3 T lung magnetic resonance imaging in children with allergic bronchopulmonary aspergillosis: Pilot study.

Eur J Radiol 2019 Feb 30;111:88-92. Epub 2018 Dec 30.

Department of Pulmonary Medicine, PGIMER, Chandigarh, India.

Objective: To evaluate the diagnostic performance of 3 T lung magnetic resonance imaging (MRI) in children with allergic bronchopulmonary aspergillosis (ABPA).

Materials And Methods: This study protocol was approved by the institutional ethics committee. From October 2015 to January 2018, we prospectively evaluated twenty-seven consecutive children with ABPA. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.12.021DOI Listing
February 2019
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First case of Aspergillus caelatus airway colonization in a Chronic Obstructive Pulmonary Disease patient.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique universités, EA1155-IICiMed, Nantes, France; Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia; Clínica Universitaria Colombia, Bogotá, Colombia.

Background: During a cross-sectional study on allergic aspergillosis in Chronic Obstructive Pulmonary Disease patients in Bogotá, Colombia, we reported the case of a 65-year-female patient with GOLD 2011 D classification, presenting dyspnea at the time of visit and aspergillus in repeated sputum cultures.

Methods: The isolate was identified at the section level based on macroscopic and microscopic characteristics and gene sequencing was used for precise molecular identification. Antifungal sensibility was determined by Sensititre YeastOne™ while virulence was assessed using Galleria mellonella larvae model. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.043DOI Listing
January 2019
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Current State of the Diagnosis of Invasive Pulmonary Aspergillosis in Lung Transplantation.

Front Microbiol 2018 9;9:3273. Epub 2019 Jan 9.

Transplant Infectious Diseases, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

As the number of lung transplants performed worldwide each year continues to grow, the success of this procedure is threatened by the incidence of non-CMV infections such as invasive aspergillosis. Despite tremendous efforts and the availability of numerous diagnostic tests (especially in hematological malignancies) the diagnosis of invasive aspergillosis continues to be a challenge. Lung transplantation remains a unique clinical scenario, where additional host defenses are immunocompromized, making many of the available tests unsuitable. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333628PMC
January 2019
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Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections.

J Mycol Med 2019 Jan 24. Epub 2019 Jan 24.

Department of Ecology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, 142, Bulevar despota Stefana, 11060 Belgrade, Serbia; Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, 16, Studentski trg, 11000 Belgrade, Serbia. Electronic address:

Aspergillosis represents a spectrum of fungal diseases which are caused by fungi of the genus Aspergillus. Animal models have been developed and used to address immune-based mechanisms of defense against these fungi. Invertebrate models enabled mass screening of virulence attributes of Aspergillus species as well as mechanisms of acquired resistance to antifungal agents. Read More

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http://dx.doi.org/10.1016/j.mycmed.2019.01.006DOI Listing
January 2019
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Monitoring treatment response in chronic pulmonary aspergillosis: role of clinical, spirometric and immunological markers.

Clin Microbiol Infect 2019 Jan 25. Epub 2019 Jan 25.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address:

Objectives: The treatment response in chronic pulmonary aspergillosis (CPA) is usually assessed based on the improvement in clinical and imaging findings. Herein, we evaluate serum Aspergillus fumigatus-specific IgG, serum galactomannan, weight change, and lung function for assessing treatment response in subjects with CPA.

Methods: We categorized treatment response as favourable (improved or stable clinical response with radiologically improved or stable disease) or unfavourable (worsening of symptoms or radiological progression) after 6 months of treatment with antifungal azoles. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.007DOI Listing
January 2019
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Aspergillosis in a Child with Acute Myeloid Leukemia: Complications, and Treatment.

J Dent (Shiraz) 2018 Dec;19(4):320-324

Dept. of Pediatric Dentistry, Oral and Dental Research Center, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.

Microbial infection is common in patients with leukemia. However, aspergillosis is a rare complication of oral region. Attention to early diagnosis and multidisciplinary treatment can reduce the wide range of complications of the infection in these patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338690PMC
December 2018
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