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    Invasive Aspergillus Laryngotracheobronchitis in an Adult with Primary CNS Lymphoma.
    Mycopathologia 2017 Feb 17. Epub 2017 Feb 17.
    Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA, 19104, USA.
    Invasive aspergillosis can be difficult to diagnose, and early recognition and initiation of therapy is imperative for improving patient outcomes. A case of invasive Aspergillus laryngotracheobronchitis is presented here with a review of the relevant literature. A 58-year-old male undergoing treatment for CNS lymphoma presented with neutropenic sepsis and acute respiratory distress requiring intubation. Read More

    Serious fungal infections in Egypt.
    Eur J Clin Microbiol Infect Dis 2017 Feb 17. Epub 2017 Feb 17.
    The University of Manchester and National Aspergillosis Centre, University Hospital of South Manchester, The University of Manchester, Manchester, UK.
    We aimed to estimate the burden of serious fungal infections in Egypt, currently unknown, based on the size of the populations at risk and available epidemiological data. Data were obtained from the World Health Organization (WHO), the Joint United Nations Programme on HIV/AIDS (UNAIDS), and published reports with clearcut denominators. When no data existed, risk populations were used to estimate frequencies of fungal infections, using previously described methodology. Read More

    Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development.
    Front Microbiol 2017 1;8:92. Epub 2017 Feb 1.
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover NH, USA.
    Sterols are a major component of eukaryotic cell membranes. For human fungal infections caused by the filamentous fungus Aspergillus fumigatus, antifungal drugs that target sterol biosynthesis and/or function remain the standard of care. Yet, an understanding of A. Read More

    High incidence of non-tuberculous mycobacteria-positive cultures among adolescent with cystic fibrosis.
    J Cyst Fibros 2017 Feb 12. Epub 2017 Feb 12.
    Cystic Fibrosis Adult Care Center, Department of Internal Medicine, Hospices Civils de Lyon, Lyon, France; Université Claude Bernard Lyon 1, France; EA HESPER 7425, Université Claude Bernard Lyon 1, France.
    Background: We evaluated the prevalence of non-tuberculous mycobacteria (NTM)-positive cultures among our cystic fibrosis (CF) center patients, reviewed risk factors for NTM positivity, and determined its impact on lung function evolution.

    Methods: From 2009 to 2014, CF adults and children attending the CF center of Lyon (France) and having at least one positive NTM isolate were included. Each case was matched by age and gender with two CF patients with no NTM isolate (controls). Read More

    Curvularia lunata, a rare fungal peritonitis in continuous ambulatory peritoneal dialysis (CAPD); a rare case report.
    J Nephropharmacol 2016 21;5(1):61-62. Epub 2015 Dec 21.
    Department of Nephrology, Sri Ramachandra Medical College and Hospital, Sri Ramachandra University, Chennai, India.
    Peritonitis is an inflammation of the peritoneum that occurs in patients with end-stage renal disease (ESRD) treated by peritoneal dialysis. Fungal peritonitis is a dreaded complication of peritoneal dialysis. Curvularia lunata is known to cause extra renal disease like endocarditis, secondary allergic bronchopulmonary aspergillosis and endophthalmitis. Read More

    SYBR safe(TM) efficiently replaces ethidium bromide in Aspergillus fumigatus gene disruption.
    Genet Mol Res 2017 Feb 8;16(1). Epub 2017 Feb 8.
    Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil
    Invasive aspergillosis is a disease responsible for high mortality rates, caused mainly by Aspergillus fumigatus. The available drugs are limited and this disease continues to occur at an unacceptable frequency. Gene disruption is essential in the search for new drug targets. Read More

    Performance of Galactomannan Antigen, Beta-d-Glucan, and Aspergillus-Lateral-Flow Device for the Diagnosis of Invasive Aspergillosis.
    Indian J Hematol Blood Transfus 2017 Mar 9;33(1):87-92. Epub 2016 Feb 9.
    0000 0001 2331 2603grid.411739.9Departments of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
    Aspergillus lateral-flow device (LFD) was recently introduced as a practical tool for the diagnosis of invasive aspergillosis (IA). We investigated the performance of Aspergillus-LFD as a point-of-care test for the diagnosis of IA. Serum samples were collected twice weekly from patients who received intensive chemotherapy for acute leukemia, or recepients of allogeneic stem cell transplantation. Read More

    First isolation of the pan-azole-resistant Aspergillus fumigatus cyp51A TR46/Y121F/T289A mutant in a UK patient.
    Int J Antimicrob Agents 2017 Feb 9. Epub 2017 Feb 9.
    Mycology Reference Centre Manchester, University Hospital of South Manchester, Manchester, UK; National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK; The University of Manchester, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, Division of Infection, Immunity and Respiratory Medicine, Manchester, UK. Electronic address:

    Serious fungal infections in Chile.
    Eur J Clin Microbiol Infect Dis 2017 Feb 10. Epub 2017 Feb 10.
    University of Manchester, Manchester Academic Health Science Centre and National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK.
    The incidence and prevalence of fungal infections in Chile are unknown. Here, we have estimated the burden of serious fungal diseases from data obtained from clinical reports, WHO reports, Chilean census, OECD reports and comprehensive literature search available on PubMed and SciELO, among other scientific resources. Due the lack of official data about fungal diseases, frequencies were calculated based on the specific populations at risk. Read More

    Serious fungal infections in Portugal.
    Eur J Clin Microbiol Infect Dis 2017 Feb 10. Epub 2017 Feb 10.
    The University of Manchester and National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK.
    There is a lack of knowledge on the epidemiology of fungal infections worldwide because there are no reporting obligations. The aim of this study was to estimate the burden of fungal disease in Portugal as part of a global fungal burden project. Most published epidemiology papers reporting fungal infection rates from Portugal were identified. Read More

    Serious fungal infections in Peru.
    Eur J Clin Microbiol Infect Dis 2017 Feb 10. Epub 2017 Feb 10.
    Investigaciones Medicas en Salud, Calle Riso 390, 4to piso, Lince, Lima14, Lima, Peru.
    Epidemiological data about mycotic diseases are limited in Peru and estimation of the fungal burden has not been previously attempted. Data were obtained from the Peruvian National Institute of Statistics and Informatics, UNAIDS and from the Ministry of Health's publications. We also searched the bibliography for Peruvian data on mycotic diseases, asthma, COPD, cancer and transplants. Read More

    Unexpected extrapyramidal symptoms and pulmonary aspergillosis in exertional heatstroke with fulminant liver failure: a case report.
    J Med Case Rep 2017 Feb 10;11(1):37. Epub 2017 Feb 10.
    Critical Care Medicine, Chinese PLA General Hospital, 28th Fuxing Road, Haidian District, Beijing, 100853, China.
    Background: Exertional heatstroke is a life-threatening condition with high mortality because of the rapid progress of multiple organ dysfunction syndrome even if aggressive treatments are initiated rapidly. Mild to moderate hepatic injury is common in exertional heatstroke, while fulminant liver failure is rare. Extrapyramidal symptoms and pulmonary aspergillosis secondary to liver failure induced by exertional heatstroke have never been reported in prior cases. Read More

    Prognostic value of galactomannan: current evidence for monitoring response to antifungal therapy in patients with invasive aspergillosis.
    J Pharmacokinet Pharmacodyn 2017 Feb 8. Epub 2017 Feb 8.
    Antimicrobial Pharmacodynamics and Therapeutics, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
    Galactomannan (GM) is a polysaccharide present in the cell wall of Aspergillus spp. that is released during growth of the organism. It has been successfully used to aide in the diagnosis of invasive aspergillosis allowing for earlier recognition of disease compared to conventional methods. Read More

    Invasive Aspergillosis of Anterior Skull Base in the Immunocompetent Host: Outcomes with a Combined Treatment Modality-An Institutional Experience.
    J Neurol Surg B Skull Base 2017 Feb 18;78(1):89-95. Epub 2016 Jul 18.
    Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Objectives To study outcomes with voriconazole therapy in immunocompetent individuals following maximal safe endoscopic resection in invasive aspergillosis of the anterior skull base. Design Retrospective study of patients with chronic invasive aspergillosis including symptomatology, extent of disease, and response to voriconazole following maximal safe resection in immunocompetent individuals. Setting Tertiary care superspeciality referral center. Read More

    Awareness of predictors of mortality may help improve outcome in chronic pulmonary aspergillosis.
    Eur Respir J 2017 Feb 8;49(2). Epub 2017 Feb 8.
    Department I of Internal Medicine, Clinical Trials Centre Cologne, Centre for Integrated Oncology Köln Bonn, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, German Centre for Infection Research, University of Cologne, Cologne, Germany

    Predictors of mortality in chronic pulmonary aspergillosis.
    Eur Respir J 2017 Feb 8;49(2). Epub 2017 Feb 8.
    The National Aspergillosis Centre, University Hospital of South Manchester, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Chronic pulmonary aspergillosis (CPA) is a chronic progressive infection that destroys lung tissue in non-immunocompromised patients. Contemporary series suggest 50-85% 5-year mortality, with few prognostic factors identified.A cohort of 387 CPA patients referred to the UK's National Aspergillosis Centre from 1992 to June 2012 was studied until June 2015. Read More

    Infectious Causes of Right Middle Lobe Syndrome.
    Cancer Control 2017 Jan;24(1):60-65
    Department of Infectious Diseases, Moffitt Cancer Center, Tampa, FL.
    Right middle lobe (RML) syndrome is defined as recurrent or chronic obstruction or infection of the middle lobe of the right lung. Nonobstructive causes of middle lobe syndrome include inflammatory processes and defects in the bronchial anatomy and collateral ventilation. We report on 2 case patients with RML syndrome, one due to infection with Mycobacterium avium complex followed by M asiaticum infection and the other due to allergic bronchopulmonary aspergillosis. Read More

    Prospective multicenter German study on pulmonary colonization with Scedosporium /Lomentospora species in cystic fibrosis: Epidemiology and new association factors.
    PLoS One 2017 8;12(2):e0171485. Epub 2017 Feb 8.
    Reference Laboratory for Cryptococcosis, Scedosporiosis and Imported Systemic Mycoses, FG 16, Robert Koch Institute, Berlin, Germany.
    Background: An increasing rate of respiratory colonization and infection in cystic fibrosis (CF) is caused by fungi of the Scedosporium apiospermum species complex or Lomentospora prolificans (Sac-Lp). These fungi rank second among the filamentous fungi colonizing the CF airways, after Aspergillus fumigatus. However, the epidemiology, clinical relevance and risk of pulmonary colonization with Sac-Lp are rarely understood in CF. Read More

    [Pulmonary co-infection due to Nocardia cyriacigeorgica and Aspergillus fumigatus].
    Rev Esp Quimioter 2017 Feb 8. Epub 2017 Feb 8.
    Rocío Trastoy, Servicio de Microbiología y Parasitología. Complejo Hospitalario Universitario de Santiago de Compostela. Travesía de Choupana, s/n, 15706 Santiago de Compostela, A Coruña, Spain.
    Objective: Pulmonary nocardiosis is an uncommon pulmonary infection caused by aerobic gram-positive bacteria of the genus Nocardia. Nocardia sp. are environmental organisms spread worldwide. Read More

    [Lung Adenocarcinoma with Pulmonary Aspergillosis Showing Cavity Disappearance;Report of a Case].
    Kyobu Geka 2017 Feb;70(2):151-154
    Department of General Thoracic Surgery, Kochi Health Sciences Center, Kochi, Japan.
    A 49-year-old man complaining of fever, chest pain, and hemosputum was examined at a local hospital. A chest computed tomography (CT) scan revealed a 35 mm mass shadow with cavity in the right upper lobe, but a transbronchial lung biopsy could not establish a complete diagnosis. After 1 month follow-up, the patient was referred to our hospital because the mass shadow wall remained thick despite the cavity shrinking. Read More

    A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus.
    MBio 2017 Feb 7;8(1). Epub 2017 Feb 7.
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    Invasive aspergillosis (IA), caused by the filamentous fungal pathogen Aspergillus fumigatus, is a major cause of death among immunocompromised patients. The cyclic AMP/protein kinase A (PKA) signaling pathway is essential for hyphal growth and virulence of A. fumigatus, but the mechanism of regulation of PKA remains largely unknown. Read More

    Central nervous system infections in immunocompromised patients.
    Curr Opin Crit Care 2017 Feb 4. Epub 2017 Feb 4.
    aAP-HP, Bichat Hospital, Department of Intensive Care Medicine and Infectious Diseases, Paris Diderot University bUMR1148, LVTS, Sorbonne Paris Cité, INSERM/Paris Diderot University, Paris, France cDepartment of Intensive Care Medicine, University Hospitals Leuven, KULeuven, Leuven, Belgium.
    Purpose Of Review: Although rare, central nervous system (CNS) infections are increasingly being recognized in immunocompromised patients. The goal of the present review is to provide a practical diagnostic approach for the intensivist, and to briefly discuss some of the most prevalent conditions.

    Recent Findings: Immunocompromised patients presenting with new neurological symptoms should always be suspected of a CNS infection. Read More

    Global Population Genetic Analysis of Aspergillus fumigatus.
    mSphere 2017 Jan-Feb;2(1). Epub 2017 Feb 1.
    Department of Biology, McMaster University, Hamilton, Ontario, Canada; Public Research Laboratory and Institute of Tropical Diseases Research, Hainan Medical University, Haikou, Hainan, China.
    Aspergillus fumigatus is a ubiquitous opportunistic fungal pathogen capable of causing invasive aspergillosis, a globally distributed disease with a mortality rate of up to 90% in high-risk populations. Effective control and prevention of this disease require a thorough understanding of its epidemiology. However, despite significant efforts, the global molecular epidemiology of A. Read More

    Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes.
    Case Reports Immunol 2017 10;2017:2676403. Epub 2017 Jan 10.
    Pediatric Immunology Department, Medical Faculty, Ege University, Izmir, Turkey.
    Chronic granulomatous disease (CGD) is a primary immune deficiency causing predisposition to infections with specific microorganisms, Aspergillus species and Staphylococcus aureus being the most common ones. A 16-year-old boy with a mutation in CYBB gene coding gp91(phox) protein (X-linked disease) developed a liver abscess due to Staphylococcus aureus. In addition to medical therapy, surgical treatment was necessary for the management of the disease. Read More

    A Rare Case of Bilateral Aspergillomas in a Patient of Ankylosing Spondylitis.
    Kathmandu Univ Med J (KUMJ) 2016 Apr-Jun;14(54):177-180
    Department of Pulmonary Medicine, Medical College, Kolkata, West Bengal, India.
    Pulmonary involvement by Aspergillus sp. mainly includes allergic bronchopulmonary aspergillosis, aspergilloma, and invasive aspergillosis. Aspergilloma (Fungal ball) is the most common form of aspergillous pulmonary involvement, which occurs in preexisting pulmonary cavities, especially secondary to pulmonary tuberculosis. Read More

    Aspergillosis associated with surgically assisted rapid maxillary expansion.
    Natl J Maxillofac Surg 2016 Jan-Jun;7(1):105-107
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
    Surgically assisted rapid palatal expansion (SARPE) is one of the most common orthognathic surgery operations for the treatment of maxillary transverse deficiencies. Although this operation is considered technically simple and has low complication rate, predisposing factors can complicate the postoperative period. In this case report, fistula formation and aspergillosis after SARPE operation were presented. Read More

    Serious fungal infections in Canada.
    Eur J Clin Microbiol Infect Dis 2017 Feb 4. Epub 2017 Feb 4.
    Department of Microbiology and Immunology and Department of Medicine, Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Center, McGill University, Montréal, Canada.
    There are currently no nationwide epidemiological data on fungal infections in Canada. We estimated the burden of serious fungal diseases using literature review and modeling, as per a methodology previously described by the LIFE program ( http://www.LIFE-worldwide. Read More

    Burden of serious fungal infections in Bangladesh.
    Eur J Clin Microbiol Infect Dis 2017 Feb 4. Epub 2017 Feb 4.
    Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
    In Bangladesh there are several published papers on superficial mycoses. Deep mycoses are also recognized as an important emerging problem. Here, we estimate the annual incidence and prevalence of serious fungal infections in Bangladesh. Read More

    Serious fungal infections in Korea.
    Eur J Clin Microbiol Infect Dis 2017 Feb 4. Epub 2017 Feb 4.
    Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Information on the incidence and prevalence of fungal infections is of critical value in public health policy. However, nationwide epidemiological data on fungal infections are scarce, due to a lack of surveillance and funding. The objective of this study was to estimate the disease burden of fungal infections in the Republic of Korea. Read More

    Serious fungal infections in Thailand.
    Eur J Clin Microbiol Infect Dis 2017 Feb 4. Epub 2017 Feb 4.
    The National Aspergillosis Centre in association with the LIFE program at www.LIFE-worldwide.org, The University of Manchester, Manchester, UK.
    The burden of serious fungal infection in Thailand is increasing but data regarding its incidence and prevalence are lacking. In this study we aimed to estimate the burden of serious fungal diseases in Thailand based on the size of the populations at risk and available epidemiological databases. Data derived from The Bureau of Epidemiology, Department of Disease Control, Thai Ministry of Public Health, World Health Organisation, international and local reports, and some unreported data were used. Read More

    Serious fungal infections in Pakistan.
    Eur J Clin Microbiol Infect Dis 2017 Feb 4. Epub 2017 Feb 4.
    Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
    The true burden of fungal infection in Pakistan is unknown. High-risk populations for fungal infections [tuberculosis (TB), diabetes, chronic respiratory diseases, asthma, cancer, transplant and human immunodeficiency virus (HIV) infection] are numerous. Here, we estimate the burden of fungal infections to highlight their public health significance. Read More

    Serious fungal infections in Ecuador.
    Eur J Clin Microbiol Infect Dis 2017 Feb 4. Epub 2017 Feb 4.
    Facultad de Medicina, Pontificia Universidad Católica del Ecuador, Quito, Ecuador.
    There is a dearth of data from Ecuador on the burden of life-threatening fungal disease entities; therefore, we estimated the burden of serious fungal infections in Ecuador based on the populations at risk and available epidemiological databases and publications. A full literature search was done to identify all epidemiology papers reporting fungal infection rates. WHO, ONU-AIDS, Index Mundi, Global Asthma Report, Globocan, and national data [Instituto Nacional de Estadística y Censos (INEC), Ministerio de Salud Pública (MSP), Sociedad de Lucha Contra el Cáncer (SOLCA), Instituto Nacional de Donación y Trasplante de Órganos, Tejidos y Células (INDOT)] were reviewed. Read More

    Severe pneumonia associated with ibrutinib monotherapy for CLL and lymphoma.
    Hematol Oncol 2017 Feb 3. Epub 2017 Feb 3.
    Hematology Unit, Bnai Zion Medical Center, Haifa, Israel.
    In recent years, there have been major advances in the treatment of chronic lymphocytic leukemia (CLL) particularly since the development of novel therapeutic agents, mostly "biological drugs." One of the obvious advantages of these agents is the decreased rate of infectious complications occurring during the course of therapy, compared to the use of standard immuno-chemotherapy regimens. Here, we describe 3 patients with CLL and 1 with mantle cell lymphoma who developed severe life-threatening pneumonias, during monotherapy with ibrutinib. Read More

    Computed tomographic assessment of a new nonsurgical sinus trephination technique using a medical bone marrow drill.
    Can J Vet Res 2017 Jan;81(1):53-58
    Department of Small Animal Clinical Sciences (Caudal, Snead, Starrak, Sathya) and Statistics (Feng), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
    The objective of this study was to determine the feasibility of trephination of the frontal sinus and injection of antifungal cream using a medical bone marrow drill in dogs. Results were compared with frontal sinus trephination using a standard surgical technique. Bilateral trephination of the frontal sinuses was carried out in the heads of 11 cadavers using a medical bone marrow drill and a surgical bone chuck. Read More

    Fulminant Laryngeal-tracheobronchial-pulmonary Aspergillosis: A Rare and Fatal Complication in Allogeneic Hematopoietic Stem Cell Transplantation Recipients.
    Intern Med 2017 1;56(3):347-351. Epub 2017 Feb 1.
    Department of Hematology, the Xinghai Hospital of Suzhou Industrial Park, China.
    A 23-year-old man who had previously undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia was diagnosed with invasive laryngeal-tracheobronchial-pulmonary aspergillosis after presenting with a persistent dry cough at six months post-transplantation based on the findings of laryngoscopy and fiberoptic bronchoscopy. A fiberoptic bronchoscope was used to remove the obstructive material from the patient's airway and posaconazole plus caspofungin were administered to successfully to treat the patient. Our report suggests that laryngoscopy and fiberoptic bronchoscopy should be considered as alternative approaches to the diagnosis and treatment of allo-HSCT recipients with persistent respiratory symptoms when invasive laryngeal aspergillosis and invasive tracheobronchial aspergillosis are suspected. Read More

    A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring.
    BMC Pharmacol Toxicol 2017 Jan 31;18(1). Epub 2017 Jan 31.
    Division of Infectious Diseases, Department of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.
    Background: Invasive aspergillosis (IA) is a fatal infectious complication among immunocompromised patients. Aspergillus terreus, the fourth common species can be difficult to treat due to a unique resistance pattern. To date, there has been no report on safety and dose adjustment when intravenous posaconazole is selected in hepatic and renal impairment patient. Read More

    Is a biomarker-based diagnostic strategy for invasive aspergillosis cost effective in high-risk haematology patients?
    Med Mycol 2017 Jan 27. Epub 2017 Jan 27.
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, 2 St Andrews Pl, East Melbourne, VIC 3002, Australia
    Empirical antifungal therapy is frequently used in hematology patients at high risk of invasive aspergillosis (IA), with substantial cost and toxicity. Biomarkers for IA aim for earlier and more accurate diagnosis and targeted treatment. However, data on the cost-effectiveness of a biomarker-based diagnostic strategy (BDS) are limited. Read More

    Respiratory Complications Lead to the Diagnosis of Chronic Granulomatous Disease in Two Adult Patients.
    J Clin Immunol 2017 Jan 27. Epub 2017 Jan 27.
    Clinical Immunology and Internal Medicine, Center for Rare Autoimmune Diseases, Strasbourg University Hospital, CNRS 3572, Strasbourg, France.
    Chronic granulomatous disease (CGD) is a primary immunodeficiency associated to multiple life-threatening bacterial and fungal infections, beginning in childhood. There are rare cases of diagnosis in adulthood. We describe here two cases of late diagnosis in adults: a 45-year-old woman and 59-year-old-man. Read More

    Risk Factors and Outcomes of Invasive Fungal Infections in Allogeneic Hematopoietic Cell Transplant Recipients.
    Mycopathologia 2017 Jan 25. Epub 2017 Jan 25.
    Huntsman Cancer Center, University of Utah, Salt Lake City, UT, USA.
    Allogeneic hematopoietic cell transplant (HCT) recipients are at increased risk of invasive fungal infections (IFI), which are associated with a high mortality rate. We evaluated the impact of IFI in allogeneic HCT patients. In total, 541 consecutive allogeneic HCT recipients were included. Read More

    cipC is important for Aspergillus fumigatus virulence.
    APMIS 2017 Feb;125(2):141-147
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
    Aspergillus fumigatus is the main causative agent of invasive aspergillosis, a disease that affects immunocompromised patients and has a high mortality rate. We previously observed that the transcription of a cipC-like gene was increased when A. fumigatus encountered an increased CO2 concentration, as occurs during the infection process. Read More

    The halo sign: HRCT findings in 85 patients.
    J Bras Pneumol 2016 Nov-Dec;42(6):435-439
    . Programa de Pós-Graduação em Medicina (Radiologia), Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil.
    Objective:: The halo sign consists of an area of ground-glass opacity surrounding pulmonary lesions on chest CT scans. We compared immunocompetent and immunosuppressed patients in terms of halo sign features and sought to identify those of greatest diagnostic value.

    Methods:: This was a retrospective study of CT scans performed at any of seven centers between January of 2011 and May of 2015. Read More

    Cost-effectiveness analysis of combination antifungal therapy with voriconazole and anidulafungin versus voriconazole monotherapy for primary treatment of invasive aspergillosis in Spain.
    Clinicoecon Outcomes Res 2017 30;9:39-47. Epub 2016 Dec 30.
    Pharmacoeconomics Department, Health Value, Madrid, Spain.
    Objective: According to a recent randomized, double-blind clinical trial comparing the combination of voriconazole and anidulafungin (VOR+ANI) with VOR monotherapy for invasive aspergillosis (IA) in patients with hematologic disease or with hematopoietic stem cell transplant, mortality was lower after 6 weeks with VOR+ANI than with VOR monotherapy in a post hoc analysis of patients with galactomannan-based IA. The objective of this study was to compare the cost-effectiveness of VOR+ANI with VOR, from the perspective of hospitals in the Spanish National Health System.

    Methods: An economic model with deterministic and probabilistic analyses was used to determine costs per life-year gained (LYG) for VOR+ANI versus VOR in patients with galactomannan-based IA. Read More

    Renal Allograft Aspergillus Infection Presenting With Obstructive Uropathy: A Case Report.
    Transplant Proc 2017 Jan - Feb;49(1):193-197
    King Abdulaziz Medical City, Western Region, Jeddah, Saudi Arabia; King Saud Bin Abdulaziz University, Saudi Arabia. Electronic address:
    Background: Isolated renal allograft aspergillosis is rare and usually presents with fever and decreased glomerular filtration rate. Presentation with obstructive uropathy caused by aspergillus fungal balls is much less common. We report a young male patient who presented with obstructive uropathy secondary to isolated renal allograft aspergillus infection 6 weeks after transplant. Read More

    Seven cases of localized invasive sino-orbital aspergillosis.
    Jpn J Ophthalmol 2017 Jan 17. Epub 2017 Jan 17.
    Department of Microbiology, Tokyo Medical University Graduate School of Medicine, Tokyo, Japan.
    Purpose: To describe the clinical manifestations and prognoses in 7 patients with invasive sino-orbital aspergillosis (ISOA).

    Methods: This was a retrospective study of consecutive patients who were diagnosed as having ISOA at the Gifu University Hospital and Gifu Municipal Hospital between January 1993 and December 2015. Data were collected on demographics, initial manifestations, examination findings, treatments, clinical course, and outcomes. Read More

    Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma.
    PLoS Pathog 2017 Jan 17;13(1):e1006175. Epub 2017 Jan 17.
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States of America.
    Aspergillus fumigatus causes invasive pulmonary disease in immunocompromised hosts and allergic asthma in atopic individuals. We studied the contribution of lung eosinophils to these fungal diseases. By in vivo intracellular cytokine staining and confocal microscopy, we observed that eosinophils act as local sources of IL-23 and IL-17. Read More

    Diagnosis, classification, and therapeutic interventions for sinopulmonary Aspergillosis.
    Expert Rev Respir Med 2017 Jan 27:1-10. Epub 2017 Jan 27.
    c Transplantation-Oncology Infectious Diseases Program , Weill Cornell Medical Center , New York , NY , USA.
    Introduction: Sinopulmonary aspergillosis represents a diverse collection of allergic, invasive, and chronic sinus and respiratory conditions. These diseases can affect patients with and without immune impairment and in some cases may be life-threatening. Areas covered: We review the diagnosis, classification, and therapeutic options available to treat sinopulmonary aspergillosis and look ahead to emerging diagnostic and therapeutic options that may soon play an important role in clinical practice. Read More

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