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    High probability of comorbidities in bronchial asthma in Germany.
    NPJ Prim Care Respir Med 2017 Apr 21;27(1):28. Epub 2017 Apr 21.
    Department of Experimental Pneumology and Allergology, Saarland University Faculty of Medicine, Homburg/Saar, Germany.
    Clinical experience has shown that allergic and non-allergic respiratory, metabolic, mental, and cardiovascular disorders sometimes coexist with bronchial asthma. However, no study has been carried out that calculates the chance of manifestation of these disorders with bronchial asthma in Saarland and Rhineland-Palatinate, Germany. Using ICD10 diagnoses from health care institutions, the present study systematically analyzed the co-prevalence and odds ratios of comorbidities in the asthma population in Germany. Read More

    Co-colonisation with Aspergillus fumigatus and Pseudomonas aeruginosa is associated with poorer health in cystic fibrosis patients: an Irish registry analysis.
    BMC Pulm Med 2017 Apr 21;17(1):70. Epub 2017 Apr 21.
    Cystic Fibrosis Registry of Ireland, Woodview house, UCD Belfield, Dublin 4, Ireland.
    Background: Pulmonary infection is the main cause of death in cystic fibrosis (CF). Aspergillus fumigatus (AF) and Pseudomonas aeruginosa (PA) are the most prevalent fungal and bacterial pathogens isolated from the CF airway, respectively. Our aim was to determine the effect of different colonisation profiles of AF and PA on the clinical status of patients with CF. Read More

    Invasive aspergillosis in patients with underlying liver cirrhosis: a prospective cohort study.
    Med Mycol 2017 Apr 20. Epub 2017 Apr 20.
    Medical University of Graz, Section of Infectious Diseases and Tropical Medicine, Auenbruggerplatz 15, 8036 Graz, Austria.
    The aim of this study was to determine the prevalence of invasive aspergillosis (IA) in patients with liver cirrhosis and the performance of serum galactomannan (GM) screening. Patients with decompensated liver cirrhosis and patients with compensated liver cirrhosis presenting with fever and/or respiratory symptoms were prospectively enrolled. All patients were screened by serum GM twice weekly irrespective of clinical signs and symptoms. Read More

    Characterization of the rax1 gene encoding a putative regulator of G protein signaling in Aspergillus fumigatus.
    Biochem Biophys Res Commun 2017 Apr 17. Epub 2017 Apr 17.
    Department of Microbiology, Graduate School, Daejeon University, Daejeon 300-716, Republic of Korea. Electronic address:
    The filamentous fungus Aspergillus fumigatus is the major cause of life threatening invasive aspergillosis, and its small hydrophobic asexual spores (conidia) are the major infection agent. To better understand biology of A. fumigatus, we have characterized the rax1 gene encoding a putative regulator of G protein signaling (RGS). Read More

    Complications of chronic necrotizing pulmonary aspergillosis: review of published case reports.
    Rev Inst Med Trop Sao Paulo 2017 Apr 13;59(0):e19. Epub 2017 Apr 13.
    Clinical Centre of Serbia, Clinic for Infectious and Tropic Diseases, Belgrade, Serbia.
    Chronic necrotizing pulmonary aspergillosis (CNPA), a form of chronic pulmonary aspergillosis (CPA), affects immunocompetent or mildly immunocompromised persons with underlying pulmonary disease. These conditions are associated with high morbidity and mortality and often require long-term antifungal treatment. The long-term prognosis for patients with CNPA and the potential complications of CNPA have not been well documented. Read More

    Detection of (1,3)-β-d-Glucan for the Diagnosis of Invasive Fungal Infection in Liver Transplant Recipients.
    Int J Mol Sci 2017 Apr 19;18(4). Epub 2017 Apr 19.
    Mycology Unit-Microbiology department, DHU "Virus, Immunité, Cancer" VIC, AP-HP Henri Mondor Hospital, 94100 Creteil, France.
    Invasive fungal infections (IFI) are complications after liver transplantation involving high morbidity and mortality. (1,3)-β-d-glucan (BG) is a biomarker for IFI, but its utility remains uncertain. This study was designed to evaluate the impact of BG following their diagnosis. Read More

    In vivo efficacy of liposomal amphotericin B against wild type and azole-resistant Aspergillus fumigatus isolates in two different immunosuppressed models of invasive aspergillosis.
    Antimicrob Agents Chemother 2017 Apr 17. Epub 2017 Apr 17.
    Department of Medical Microbiology, Radboud University Medical Centre, and Centre of Expertise in Mycology Radboudumc/CWZ, Nijmegen, the Netherlands
    Using an immunocompetent murine model of invasive aspergillosis (IA), we previously reported (AAC, 2013, 57, 4, 1866-1871) that the efficacy of liposomal amphotericin B (L-AmB) is not hampered by the presence of azole resistance mutations in Aspergillus fumigatus We here investigated the role of immune suppression, i.e. neutropenic and steroid-treated, on L-AmB efficacy in mice infected with a wild type (WT) and azole-resistant Aspergillus fumigatus harboring TR34/L98H mutation in cyp-51A gene. Read More

    A Prospective International Aspergillus terreus Survey: An EFISG, ISHAM and ECMM Joint Study.
    Clin Microbiol Infect 2017 Apr 13. Epub 2017 Apr 13.
    Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck/Austria. Electronic address:
    Objectives: A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B (AMB) susceptibility of Aspergillus terreus species complex infections.

    Methods: Three hundred seventy cases from 21 countries were evaluated.

    Results: The overall prevalence of A. Read More

    A calcineurin antifungal strategy with analogs of FK506.
    Bioorg Med Chem Lett 2017 Apr 3. Epub 2017 Apr 3.
    Amplyx Pharmaceuticals, 3210 Merryfield Row, San Diego, CA 92121, United States. Electronic address:
    A novel antifungal strategy targeting the inhibition of calcineurin is described. To develop a calcineurin based inhibitor of pathogenic fungi, analogs of FK506 were synthesized that were able to permeate mammalian but not fungal cells. Antagonists in combination with FK506 were not immunosuppressive and retained antifungal activity in A. Read More

    Assessment of high-priced systemic antifungal prescriptions.
    Med Mal Infect 2017 Apr 12. Epub 2017 Apr 12.
    Pharmacy, hôpitaux universitaires de Strasbourg, université de Strasbourg, 67098 Strasbourg, France.
    Objectives: To assess compliance with international guidelines for costly antifungal prescriptions and to compare these results with a first study performed in 2007.

    Methods: Retrospective study including all costly antifungal prescriptions made in surgical and medical intensive care units and in a hepatobiliary, pancreatic, and digestive surgery unit. Prescriptions were assessed in terms of indication, dosage, and antifungal de-escalation. Read More

    Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole.
    Med Mycol Case Rep 2017 Jun 1;16:16-19. Epub 2017 Apr 1.
    Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
    Invasive aspergillosis due to azole-resistant Aspergillus fumigatus is difficult to manage. We describe a case of azole-resistant invasive aspergillosis in a female bottlenose dolphin, who failed to respond to voriconazole and posaconazole therapy. As intravenous therapy was precluded, high dose posaconazole was initiated aimed at achieving trough levels exceeding 3 mg/l. Read More

    Glucose-6-phosphate dehydrogenase deficiency and risk of invasive fungal disease in patients with acute myeloid leukemia.
    Leuk Lymphoma 2017 Apr 12:1-10. Epub 2017 Apr 12.
    a Hematology Unit, Department of Medical Sciences and Public Health , Bone Marrow Transplant Center, R. Binaghi Hospital, University of Cagliari , Cagliari , Italy.
    Invasive fungal diseases (IFD) are still a leading cause of morbidity and mortality in patients with acute myeloid leukemia (AML). Glucose-6-phosphate dehydrogenase is an enzyme that leads to the production of NADPH, required to destroy microorganisms in the respiratory burst reaction of white blood cells. We evaluated the role of G6PD deficiency in susceptibility of IFD in 108 AML patients undergoing intensive chemotherapy. Read More

    Absolute Eosinophil Count was Significantly Associated with Serum (1,3)-β-D-Glucan in Patients with Invasive Fungal Infections.
    Clin Lab 2017 Apr;63(4):749-756
    Background: Measurement of serum (1,3)-β-D-glucan has emerged as an important diagnostic strategy for invasive fungal infections (IFI). Previous studies suggested that the eosinophil count would be related with the value of serum (1,3)-β-D-glucan.

    Methods: 572 blood samples obtained from 126 patients at the First Affiliated Hospital of Zhengzhou University were analyzed. Read More

    [Expression and differential diagnostic value of serum microRNA for invasive pulmonary aspergillosis].
    Zhonghua Jie He He Hu Xi Za Zhi 2017 Apr;40(4):272-277
    Department of Respiratory Medicine, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China.
    Objective: To explore the expression and the clinical diagnostic value of serum miR-21 for invasive pulmonary aspergillosis (IPA). Methods: Outpatients and inpatients from the Fourth Affiliated Hospital of Guangxi Medical University were included in the study during June 2014 to September 2015. The IPA group had 40 patients, male 22, female 18, aged 55-68 years (mean 60 ), while the control groups included 50 patients with pulmonary tuberculosis [male 23, female 27, aged 50-62 years (mean 55 )], 50 patients with lung cancer [male 30, female 20, aged 55-70 years (mean 62)], and 50 healthy controls [male 25, female 25, aged 50-67 years (mean 60) ]. Read More

    DRUG-INDUCED ORAL ULCERATIONS: CASE REPORT.
    Acta Clin Croat 2016 06;55(2):334-7
    A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Read More

    IL-10 Overexpression Predisposes to Invasive Aspergillosis by Suppressing Antifungal Immunity.
    J Allergy Clin Immunol 2017 Apr 4. Epub 2017 Apr 4.
    Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address:
    We show that the genetically-determined overexpression of IL-10 is a risk factor for invasive aspergillosis after stem-cell transplantation. Our results identify an IL-10-mediated mechanism that regulates the balance between anti- and proinflammatory antifungal immunity. Read More


    Fungal Opportunistic Pneumonias in HIV/AIDS Patients: An Indian Tertiary Care Experience.
    J Clin Diagn Res 2017 Feb 1;11(2):DC14-DC19. Epub 2017 Feb 1.
    Director Professor, Department of Medicine, Maulana Azad Medical College and Lok Nayak Hospital , New Delhi, India .
    Introduction: Opportunistic pneumonias are a major cause of mortality and morbidity in Human Immunodeficiency Virus (HIV) reactive patients. Despite the significant role that fungi play in causation of this opportunistic mycoses, very few Indian studies have attempted to investigate the burden and aetiological spectrum of HIV/AIDS-associated fungal pneumonias.

    Aim: To document the prevalence of fungal aetiology in HIV/AIDS-related opportunistic pneumonias in an Indian setting; and to elucidate the various fungal opportunists responsible for the same. Read More

    A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit.
    J Crit Care 2017 Mar 30;40:119-127. Epub 2017 Mar 30.
    Department of Clinical Microbiology, Trinity College Dublin, Dublin, Ireland; Microbiology Department, St. James's Hospital, Dublin, Ireland.
    Purpose: The diagnosis of invasive fungal diseases (IFD) in critical care patients (CrCP) is difficult. The study investigated the performance of a set of biomarkers for diagnosis of IFD in a mixed specialty critical care unit (CrCU).

    Methods: A prospective observational study in patients receiving critical care for ≥7days was performed. Read More

    Recombinant 60-kDa heat shock protein from Paracoccidioides brasiliensis: is it a good antigen for serological diagnosis of paracoccidioidomycosis?
    Braz J Med Biol Res 2017 Apr 3;50(4):e5928. Epub 2017 Apr 3.
    Departamento de Biologia, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
    Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. Read More

    Changes in in vitro susceptibility patterns of Aspergillus to triazoles and correlation with aspergillosis outcome in a tertiary care cancer center (1999-2015).
    Clin Infect Dis 2017 Mar 31. Epub 2017 Mar 31.
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Background.: Azole-resistant aspergillosis in high risk patients with hematological malignancy or hematopoietic stem cell transplantation (HSCT) is a cause of concern.

    Methods. Read More

    Early diagnosis and treatment of invasive aspergillosis as a main determinant of outcome - review of literature according to the presented case report.
    Ann Agric Environ Med 2017 Mar;24(1):100-103
    Department of Internal Medicine, Medical University of Lublin.
    Although. Aspergillus spp infection is not the major cause of morbidity in Intensive Care Units (ICUs), mortality among patients treated for it is tremendous. Moreover, invasive aspergillosis (IA) is an independent risk factor of hospital costs and length of stay. Read More

    Invasive aspergillosis related to ibrutinib therapy for chronic lymphocytic leukemia.
    Respir Med Case Rep 2017 20;21:27-29. Epub 2017 Mar 20.
    Division of Pulmonary & Critical Care Medicine, Veterans Affairs Portland Health Care System, Oregon Health & Science University, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States; Department of Medicine, Veterans Affairs Portland Health Care System, Oregon Health & Science University, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States.
    We report a case of invasive pulmonary aspergillosis in a patient taking ibrutinib, a Bruton's tyrosine kinase inhibitor used to treat refractory chronic lymphocytic leukemia. We hypothesize that ibrutinib promoted this infection by suppressing innate immune responses against Aspergillus. Clinicians should be aware of potential Aspergillus infections in patients treated with this drug. Read More

    Genetic susceptibility to severe asthma with fungal sensitization.
    Int J Immunogenet 2017 Mar 31. Epub 2017 Mar 31.
    Division of Infection Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK.
    Severe asthma is problematic and its pathogenesis poorly understood. Fungal sensitization is common, and many patients with severe asthma with fungal sensitization (SAFS), used to denote this subgroup of asthma, respond to antifungal therapy. We have investigated 325 haplotype-tagging SNPs in 22 candidate genes previously associated with aspergillosis in patients with SAFS, with comparisons in atopic asthmatics and healthy control patients, of whom 47 SAFS, 279 healthy and 152 atopic asthmatic subjects were genotyped successfully. Read More

    Identifying rare diseases using electronic medical records: the example of allergic bronchopulmonary aspergillosis.
    Pharmacoepidemiol Drug Saf 2017 Mar 31. Epub 2017 Mar 31.
    Vaccine Discovery and Development, GSK Vaccines, Wavre, Belgium.
    Purpose: The purpose of the study is to evaluate whether primary care electronic medical records (EMRs) from patients with severe asthma can be used to identify allergic bronchopulmonary aspergillosis (ABPA) cases.

    Methods: This cross-sectional feasibility study was conducted in adults with active and severe asthma registered with the Clinical Practice Research Datalink. A set of keywords flagged terms potentially indicative of ABPA in free-text comments of patients' EMRs to produce a grid on the basis of keywords' hit or miss. Read More

    Prevalence of Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma at a tertiary care center in North India.
    Lung India 2017 Mar-Apr;34(2):150-154
    Department of Pulmonary Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Background: The prevalence of Aspergillus hypersensitivity (AH) and allergic bronchopulmonary aspergillosis (ABPA) has been variably reported. Systematic data regarding Aspergillus sensitization and ABPA are lacking from this part of the country.

    Objectives: The aim of this study was to evaluate the prevalence of AH and ABPA in Uttar Pradesh. Read More

    Scrotal granulomatous aspergillosis in a dromedary camel (Camelus dromedarius).
    BMC Vet Res 2017 Mar 29;13(1):79. Epub 2017 Mar 29.
    Department of Veterinary Disease Biology, University of Copenhagen, Ridebanevej 3, DK-1870, Frederiksberg C, Copenhagen, Denmark.
    Background: This report describes a case of primary subcutaneous aspergillosis in a 7-year-old neutered male dromedary camel (Camelus dromedarius).

    Case Presentation: The animal developed a large nodular lesion in the right scrotum two years after surgical intervention for neutering. The mass had a firm consistency and was painful at palpation. Read More

    New pharmacological opportunities for the treatment of invasive mould diseases.
    J Antimicrob Chemother 2017 Mar;72(suppl_1):i48-i58
    Department of Oncology and Haematology, Hôpital de Hautepierre and Université de Strasbourg, Strasbourg, France.
    Recently, several randomized studies have been published that will shape treatment decisions in the prevention and management of invasive mould infections. Liposomal amphotericin B is an option for empirical or targeted treatment of invasive aspergillosis or mucormycosis, but for prophylaxis therapy, the triazole class now predominates. The triazole voriconazole is currently regarded as a drug of choice for the treatment of proven or probable invasive aspergillosis, and has shown significantly higher response rates than amphotericin B deoxycholate in this setting, with fewer severe drug-related adverse events. Read More

    Invasive mould infections in the ICU setting: complexities and solutions.
    J Antimicrob Chemother 2017 Mar;72(suppl_1):i39-i47
    Department of Infectious Diseases and Clinical Microbiology, Universidad Complutense of Madrid, and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
    Infections caused by filamentous fungi represent a major burden in the ICU. Invasive aspergillosis is emerging in non-neutropenic individuals with predisposing conditions, e.g. Read More

    Early diagnosis of invasive mould infections and disease.
    J Antimicrob Chemother 2017 Mar;72(suppl_1):i19-i28
    Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
    Invasive mould infections (IMIs), such as invasive aspergillosis or mucormycosis, are a major cause of death in patients with haematological cancer and in patients receiving long-term immunosuppressive therapy. Early diagnosis and prompt initiation of antifungal therapy are crucial steps in the management of patients with IMI. The diagnosis of IMI remains a major challenge, with an increased spectrum of fungal pathogens and a diversity of clinical and radiological presentations within the expanding spectrum of immunocompromised hosts. Read More

    Utility of the Aspergillus galactomannan antigen testing for neutropenic paediatric patients.
    Infez Med 2017 Mar;25(1):38-44
    Department of Biostatistics, Faculty of Medicine, University of Erciyes, Kayseri, Turkey.
    Invasive aspergillosis (IA) is an increasingly important cause of morbidity and mortality particularly in paediatric patients. Early diagnosis and the initiation of efficacious antifungal treatments could affect the prognosis of these patients. The aim of this study was to determine the clinical contribution of Galactomannan (GM) screening in paediatric patients. Read More

    Primary pyogenic ventriculitis caused by Neisseria meningitidis: case report and review of the literature.
    JMM Case Rep 2017 Jan 31;4(1):e005078. Epub 2017 Jan 31.
    National Aspergillosis Centre, 2nd Floor, Education and Research Building Hospital , Manchester, Wythenshawe M23 9LT , UK.
    Background. Pyogenic ventriculitis is a well-known complication of meningitis, brain abscesses and intraventricular drains. Primary pyogenic ventriculitis is a rare entity and few cases have been described so far. Read More

    [The burden of fungal infections in Algeria].
    J Mycol Med 2017 Mar 22. Epub 2017 Mar 22.
    National Aspergillosis Centre, Manchester Academic Health Science Centre, The University of Manchester, University Hospital of South Manchester, Manchester, Royaume-Uni.
    In Algeria, superficial mycoses are very commonly diagnosed. Deep fungal infections are less often observed. Few data from Algeria are found in the literature. Read More

    FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus.
    Med Mycol 2017 Mar 11. Epub 2017 Mar 11.
    German National Reference Center for Invasive Fungal Infections - NRZMyk, Septomics Research Centre, Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, 07745 Jena, Germany.
    Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. Read More

    An evaluation of the performance of the Dynamiker® Fungus (1-3)-β-D-Glucan Assay to assist in the diagnosis of invasive aspergillosis, invasive candidiasis and Pneumocystis pneumonia.
    Med Mycol 2017 Mar 3. Epub 2017 Mar 3.
    Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, UK.
    Invasive fungal disease (IFD) can be caused by a range of pathogens. Conventional diagnosis has the capacity to detect most causes of IFD, but poor performance limits impact. The introduction of non-culture diagnostics, including the detection of (1-3)-β-D-Glucan (BDG), has shown promising performance for the detection of IFD in variety of clinical settings. Read More

    Evaluation of matrix-assisted laser desorption/ionization time-of-fight mass spectrometry for identification of 345 clinical isolates of Aspergillus species from 11 Korean hospitals: comparison with molecular identification.
    Diagn Microbiol Infect Dis 2017 Jan 8;87(1):28-31. Epub 2016 Oct 8.
    Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
    We evaluated the ability of the Filamentous Fungi Library 1.0 of the MALDI-TOF MS Biotyper system to identify 345 clinical Aspergillus isolates from 11 Korean hospitals. Compared with results of the internal transcribed spacer region sequencing, the frequencies of correct identification at the species-complex level were 94. Read More

    Voriconazole for prophylaxis of invasive fungal infections after allogeneic hematopoietic stem cell transplantation.
    Expert Rev Anti Infect Ther 2017 May 24;15(5):493-502. Epub 2017 Mar 24.
    c Department of Infectious Diseases , Victorian Infectious Diseases Service, Royal Melbourne Hospital , Melbourne , Australia.
    Introduction: Invasive fungal infections (IFIs) following allogeneic hematopoietic stem cell transplantation (alloHSCT) are associated with a high mortality, and accordingly most alloHSCT recipients receive prophylaxis with antifungal agents. Despite some improvement in outcomes of IFIs over time, they continue to represent substantial clinical risk, mortality, and financial burden. Areas covered: We review the main pathogens responsible for IFIs in recipients of alloHSCT, current treatment recommendations, and discuss clinical and economic considerations associated with voriconazole prophylaxis of IFIs in these patients. Read More

    Aspergillus niger infection in an immunosuppressed patient confined solely to the brain.
    BMJ Case Rep 2017 Mar 22;2017. Epub 2017 Mar 22.
    University Hospital of South Manchester, UK.
    A 68-year-old woman with a background of hypertension, stroke and rheumatoid arthritis presented to her local hospital after a 4-week history of gradual deterioration and increasing confusion with new onset right-sided weakness. Her initial CT scan revealed a rim enhancing mass lesion with surrounding oedema in the left parietal lobe for which she underwent CT stealth-guided biopsy. Microbiology culture of the 2 biopsy samples yielded Aspergillus niger and she was started on the antifungal agent voriconazole. Read More

    Usefulness of two Aspergillus PCR assays and Aspergillus galactomannan and β-D-glucan testing of bronchoalveolar lavage fluid for diagnosis of chronic pulmonary aspergillosis.
    J Clin Microbiol 2017 Mar 22. Epub 2017 Mar 22.
    Department of Respiratory Medicine, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Otaku, Tokyo 143-8540, Japan.
    We evaluated the usefulness of an Aspergillus galactomannan (GM) test, a β-D-glucan (βDG) test, and two different Aspergillus polymerase chain reaction (PCR) assays of bronchoalveolar lavage fluid (BALF) samples for diagnosis of chronic pulmonary aspergillosis (CPA). BALF samples from 28 patients with and 120 patients without CPA were collected. We calculated the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio for each test individually and in combination with other tests. Read More

    Co-morbidities in severe asthma: Clinical impact and management.
    Respirology 2017 May 22;22(4):651-661. Epub 2017 Mar 22.
    Royal Brompton and Harefield NHS Foundation Trust, London, UK.
    Patients with severe asthma represent a minority of the total asthma population, but carry a majority of the morbidity and healthcare costs. Achieving better asthma control in this group of patients is therefore of key importance. Systematic assessment of patients with possible severe asthma to identify treatment barriers and triggers of asthma symptoms, including co-morbidities, improves asthma control and reduces healthcare costs and is recommended by international guidelines on management of severe asthma. Read More

    Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital.
    Rev Soc Bras Med Trop 2017 Jan-Feb;50(1):80-85
    Departamento de Microbiologia, Imunologia, Parasitologia e Patologia, Instituto de Patologia Tropical, Universidade Federal de Goiás, Goiânia, GO, Brasil.
    Introduction:: Invasive fungal infections (IFIs) are an important complication in immunocompromised individuals, particularly neutropenic patients with hematological malignancies. In this study, we aimed to verify the epidemiology and diagnosis of IFIs in patients with hematologic problems at a tertiary hospital in Goiânia-GO, Brazil.

    Methods:: Data from 117 patients, involving 19 cases of IFIs, were collected. Read More

    Effect of allergic bronchopulmonary aspergillosis on FEV1 in children and adolescents with cystic fibrosis: a European Cystic Fibrosis Society Patient Registry analysis.
    Arch Dis Child 2017 Mar 21. Epub 2017 Mar 21.
    Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
    Objective: To evaluate the effect of allergic bronchopulmonary aspergillosis (ABPA) on FEV1 percent predicted in children and adolescents with cystic fibrosis.

    Design: Longitudinal data analysis (2008-2010).

    Setting: Patients participating in the European Cystic Fibrosis Society Patient Registry. Read More

    Oral Fungal Infections: Diagnosis and Management.
    Dent Clin North Am 2017 Apr;61(2):319-349
    Oral & Maxillofacial Surgery, Private Practice: Huntington Beach Oral & Maxillofacial Surgery, 7677 Center Avenue, Suite 206, Huntington Beach, CA 92647, USA; Long Beach Memorial Medical Center, 2801 Atlantic Avenue, Long Beach, CA 90806, USA; Oral & Maxillofacial Surgery, Division of Otolaryngology, UCI School of Medicine, 101 The City Drive South, Orange, CA 92868, USA.
    Oral and maxillofacial fungal infections can appear in high-risk patients, including those immunocompromised. This article explores common oral manifestations of fungal infections in the oral cavity as primary lesions or as a result of disseminated disease. By far the most common oral fungal infection experienced in dentistry is oral candidiasis, which is reviewed in depth from simple oral infections to invasive candidiasis. Read More

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