482,291 results match your criteria Aspects of Affect[Journal]


Dengue virus-activated platelets modulate monocyte immunometabolic response through lipid droplet biogenesis and cytokine signaling.

J Leukoc Biol 2020 Jul 14. Epub 2020 Jul 14.

Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.

Dengue is characterized as one of the most important arthropod-borne human viral diseases, representing a public health problem. Increased activation of immune cells is involved in the progression of infection to severe forms. Recently, our group demonstrated the contribution of platelet-monocyte interaction to inflammatory responses in dengue, adding to evolving evidence that platelets have inflammatory functions and can regulate different aspects of innate immune responses. Read More

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http://dx.doi.org/10.1002/JLB.4MA0620-658RDOI Listing

[Current Aspects of Definition and Diagnosis of Pulmonary Hypertension].

Pneumologie 2020 Jul 14. Epub 2020 Jul 14.

Medizinische Klinik mit Schwerpunkt Pneumologie und Beatmungsmedizin, Klinikum Würzburg Mitte, Standort Missioklinik, Würzburg.

At the 6th World Symposium on Pulmonary Hypertension (WSPH), which took place from February 27 until March 1, 2018 in Nice, scientific progress over the past 5 years in the field of pulmonary hypertension (PH) was presented by 13 working groups. The results of the discussion were published as proceedings towards the end of 2018. One of the major changes suggested by the WSPH was the lowering of the diagnostic threshold for PH from ≥ 25 to > 20 mmHg mean pulmonary arterial pressure, measured by right heart catheterization at rest. Read More

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http://dx.doi.org/10.1055/a-1199-1548DOI Listing

Seizure control and anxiety: Which factor plays a major role in social adjustment in patients with Juvenile Myoclonic Epilepsy?

Seizure 2020 Jul 2;80:234-239. Epub 2020 Jul 2.

Laboratory of Clinical Neurophysiology, Department of Psychiatry, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Brazil. Electronic address:

Purpose: This study aimed to determine the presence of anxiety disorder and severity of anxiety symptoms in an extensive series of consecutive patients with JME and its association with epilepsy-related factors. In addition, we evaluated the impact of anxiety and clinical variables on social adjustment.

Methods: We prospectively evaluated 112 (56. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.06.033DOI Listing

Challenges and advantages of cell therapy manufacturing under Good Manufacturing Practices within the hospital setting.

Curr Opin Biotechnol 2020 Jul 11;65:233-241. Epub 2020 Jul 11.

Department of Oncology, Center of Experimental Therapeutics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland; Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, 1011 Lausanne, Switzerland. Electronic address:

Academic medicine serves to advance the scientific field and provide the highest quality of clinical care. This applies to cancer where there is a continuous unmet need for innovation. In the last decade, we have observed a significant development of commercial cell and gene-therapy products with a rapid growth of the industry. Read More

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http://dx.doi.org/10.1016/j.copbio.2020.05.005DOI Listing

The incidence of intraoperative hypotension in moderate to high risk patients undergoing non-cardiac surgery: A retrospective multicenter observational analysis.

J Clin Anesth 2020 Jul 11;66:109961. Epub 2020 Jul 11.

University of Michigan, Department of Anesthesiology, 1H247 UH, SPC 5048, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5048, United States. Electronic address:

Study Objective: Intraoperative hypotension is associated with perioperative morbidity. We undertook this project to describe the incidence of hypotension (defined as mean arterial pressure <65 mmHg).

Design: Retrospective, observational study. Read More

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http://dx.doi.org/10.1016/j.jclinane.2020.109961DOI Listing

Mechanobiology of leader-follower dynamics in epithelial cell migration.

Curr Opin Cell Biol 2020 Jul 11;66:97-103. Epub 2020 Jul 11.

TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad (TIFR-H), Hyderabad 500046, India. Electronic address:

Collective cell migration is fundamental to biological form and function. It is also relevant to the formation and repair of organs and to various pathological situations, including metastatic propagation of cancer. Technological, experimental, and computational advancements have allowed the researchers to explore various aspects of collective migration, spanning from biochemical signalling to inter-cellular force transduction. Read More

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http://dx.doi.org/10.1016/j.ceb.2020.05.007DOI Listing

In honor to Ramón G. Rubio on the occasion of his 65th birthday.

Adv Colloid Interface Sci 2020 Jul 3;282:102202. Epub 2020 Jul 3.

Institut Max von Laue and Paul Langevin, 71 avenue des Martyrs, CS 20156, 38042 Grenoble, France. Electronic address:

This Honorary Note is dedicated to the 65th birthday of Ramón G. Rubio and summarizes some of his contributions to the current knowledge in the science and technology of colloids and interfaces. Since 1995, Ramón González Rubio is Full Professor at the Complutense University of Madrid (Spain) where he has developed an extensive research activity in different scientific and technological aspects related to colloidal systems and interfacial phenomena: from particle-laden interfaces to polyelectrolyte multilayers, including the kinetics of simultaneous spreading and evaporation of solutions (and dispersions) and interfacial rheology. Read More

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http://dx.doi.org/10.1016/j.cis.2020.102202DOI Listing

Repercussions of COVID-19 pandemic on municipal solid waste management: Challenges and opportunities.

Sci Total Environ 2020 Jul 2;743:140693. Epub 2020 Jul 2.

Department of Civil Engineering, R V College of Engineering (Autonomus Institute, affiliated to Visvesvaraya Technological University, Belagavi), Mysore Road, Bangalore 560059, Karnataka, India.

The COVID-19 pandemic has caused global emergency and has raised social and economic concerns which will also spill over to environmental issues. Amid this natural experiment, current study evaluates prevailing municipal solid waste (MSW) management practices, with the emphasis on MSW treatment and disposal facilities in select developed and developing countries. The data and information used in this paper is collected from several scientific research papers from different disciplines, publications from governments and multilateral agencies and media reports. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140693DOI Listing

Hierarchical fibrous guiding cues at different scales influence linear neurite extension.

Acta Biomater 2020 Jul 11. Epub 2020 Jul 11.

DWI-Leibniz Institute for Interactive Materials, Aachen, 52074, Germany; ITMC-Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, 52074, Germany; ITMC-Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, 52074, Germany.

Surface topographies at micro- and nanoscales can influence different cellular behavior, such as their growth rate and directionality. While different techniques have been established to fabricate 2-dimensional flat substrates with nano- and microscale topographies, most of them are prone to high costs and long preparation times. The 2. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.014DOI Listing

Dromedary camel: A model of heat resistant livestock animal.

Theriogenology 2020 Jun 1;154:203-211. Epub 2020 Jun 1.

Comparative Anatomy Unit/URAC49, Department of Biological and Pharmacological Veterinary Sciences, Hassan II Agronomy and Veterinary Medicine Institute, Rabat, Morocco.

Camels are highly adapted to harsh environments. The dromedary camel is adapted to a wide range of arid and semi-arid conditions. The aim of the present paper is to review some of the key adaptation characteristics of the dromedary and how they affect reproductive patterns. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.05.046DOI Listing

COVID-19 Considerations in Pediatric Dentistry.

JDR Clin Trans Res 2020 Jul 14:2380084420941503. Epub 2020 Jul 14.

Pediatric Dentistry Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

One of the most important current medical concerns across the globe is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which has been designated by the World Health Organization as a novel viral pneumonia named coronavirus disease 2019 (COVID-19). COVID-19 has substantially affected all aspects of human lives and forced most people to self-quarantine themselves and stay home in order to remain safe. As pediatric dentists as a part of the health care system deferring elective procedures, we are obliged to manage emergency situations such as cellulitis, severe tooth pain, and dental trauma. Read More

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http://dx.doi.org/10.1177/2380084420941503DOI Listing

Impact of a hydrophilic dental implant surface on osseointegration: biomechanical results in rabbit.

J Oral Implantol 2020 Jul 14. Epub 2020 Jul 14.

Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.

This study aimed to evaluate the effect of surface hydrophilicity on the biomechanical aspects of osseointegration of dental implants in the tibia and femur of rabbits. Forty-eight mature female New Zealand White rabbits were included, and 96 commercially pure, Grade 4, titanium dental implants (control group), and 96 implants of same macro geometry with the hydrophilic surface (test group) were used in this study. One osteotomy was performed in each tibia and femur on both sides of the rabbit, and four implants were placed in each rabbit. Read More

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http://dx.doi.org/10.1563/aaid-joi-D-19-00217DOI Listing

Cost-benefit Analysis of IUI and IVF based on willingness to pay approach; case study: Iran.

PLoS One 2020 14;15(7):e0231584. Epub 2020 Jul 14.

Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Assisted reproductive technologies (ARTs) are often considered luxury services by policy-makers and the general population, which are always susceptible of removal from public funding of health care. The analysis of the economic aspects of this scope seems essential due to the high prevalence of infertility in Iran and the high costs of infertility treatments. This study aimed to investigate the value put on IUI and IVF treatments by communities in Iran and the affordability of services based on community preferences. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231584PLOS

Evaluation of Disease Related Knowledge in Patients of Osteoporosis: An Observational Study.

Altern Ther Health Med 2020 Jul 15. Epub 2020 Jul 15.

Objective: Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue which results in consequent increase in bone fragility and susceptibility to fracture and more common in post-menopausal women and elderly people. This study was aimed to assess the knowledge of osteoporosis among patients in tertiary healthcare systems, as well as their knowledge of associated lifestyle, risk factors, and preventive measures.

Methods: A cross-sectional study design was used to determine the knowledge of outpatients towards osteoporosis. Read More

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Factors affecting aerobic granule sludge formation in leachate treatment - a systematic review.

Rev Environ Health 2020 Jul 14. Epub 2020 Jul 14.

Department of Environmental health engineering, Hamadan University of medical sciences, Hamadan, Iran.

The biological treatment of landfill leachate due to high concentration of Chemical Oxygen Demand (COD), ammonia, and other toxic compounds is so difficult. One of the leachate treatment technology is the sludge biogranulation, that containing the two aerobic and anaerobic process. The aim of this study was conducted for determining the main factors affecting aerobic granule sludge formation in leachate treatment. Read More

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http://dx.doi.org/10.1515/reveh-2020-0019DOI Listing

Topic modeling of social networking service data on occupational accidents: LDA analysis.

J Med Internet Res 2020 Jul 7. Epub 2020 Jul 7.

Institute of Health and Environment, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, KR.

Background: In most industrialized societies, there are regulations, inspections, insurance, and legal options to support workers who suffer from injury, disease, or death in relation to their work; in practice these resources are imperfect and or even being unavailable due to workplace or employer obstruction. Thus, limitations exist to identify unmet needs in occupational safety and health information.

Objective: This study was aimed to explore hidden issues in occupational accidents from social network services (SNS) data using topic modeling. Read More

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http://dx.doi.org/10.2196/19222DOI Listing

Usability Analysis of the "Sample Locator": a Federated Online Search Tool for Biospecimens.

J Med Internet Res 2020 Jun 14. Epub 2020 Jun 14.

Chair of Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Wetterkreuz 13, Erlangen, DE.

Background: The German Biobank Alliance (GBA) aims to establish a cross-site biobank network. For this endeavor, the so-called Sample Locator has been developed ‒ a federated search-tool for biospecimens and related data ‒ forming the heart of its IT infrastructure.

Objective: To ensure the sustainable use of such a tool, we included researchers as participants in an end user based usability evaluation. Read More

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http://dx.doi.org/10.2196/17739DOI Listing

Improving the primary care consultation through digital medical interview assistant systems - the cases of diabetes and depression: A narrative review.

J Med Internet Res 2020 Apr 27. Epub 2020 Apr 27.

Centre for Population Health Sciences (CePHaS), Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Rd, Clinical Sciences Building, Level 18, Singapore, SG.

Background: Digital medical interview assistant (DMIA, also known as computer-assisted history taking (CAHT)) systems have the potential to improve the quality of care and the medical consultation by exploring more patient-related aspects without time constraints, and therefore acquiring more and better quality information, prior to the face-to-face consultation. The consultation in primary care (PC) is the broadest in terms of the amount of topics to be covered and, at the same time, the shortest in term of time spent with the patient.

Objective: To explore how DMIA systems may be used specifically in the context of PC, to improve the consultations for diabetes and depression, as exemplars of chronic conditions. Read More

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http://dx.doi.org/10.2196/18109DOI Listing

Engagement in an interactive app for self-management of symptoms among patients treated for breast and prostate cancer: results from two randomized controlled trials.

J Med Internet Res 2020 May 20. Epub 2020 May 20.

Division of Nursing, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels Allé 23, Stockholm, SE.

Background: Using mobile technology for symptom management and self-care can improve patient-clinician communication and clinical outcomes in patients with cancer. The interactive app Interaktor has been shown to reduce symptom burden during cancer treatment. It includes symptom assessment, an alert system for contact with health care professionals, access to self-care advice, and visualization of symptom history. Read More

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http://dx.doi.org/10.2196/17058DOI Listing

The 'sober eye': examining attitudes towards non-drinkers in Australia.

Psychol Health 2020 Jul 14:1-20. Epub 2020 Jul 14.

Centre for Alcohol Policy Research, La Trobe University, Bundoora Campus, Melbourne, Australia.

Background: The proportion of Australians who choose not to drink alcohol has increased in recent years; yet, non-drinkers report experiences of stigma and judgement from peers for this choice. This study aimed to explore the attitudes that exist towards non-drinkers and examine what drives this stigma.

Method: Thematic analysis of four focus groups was undertaken, comprising 37 drinking and non-drinking Australian adults. Read More

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http://dx.doi.org/10.1080/08870446.2020.1792905DOI Listing

Can the Environmental Phagocyte Be a Useful Model to Study SARS-CoV-2 Pathogenicity, Infectivity, and Evasion of Cellular Immune Defenses?

ACS Chem Neurosci 2020 Jul 14. Epub 2020 Jul 14.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, University City, Sharjah, United Arab Emirates.

and macrophages exhibit significant parallels in biochemical, physiological, cellular, and functional aspects. Given the ability of to contribute to the evolutionary gain of pathogenicity of a variety of microbial pathogens, here we propose the use of as a paradigm to study SARS-CoV-2 pathogenicity, infectivity, and evasion of cellular immune defenses. Read More

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http://dx.doi.org/10.1021/acschemneuro.0c00401DOI Listing

En bloc GreenLight laser enucleation of the prostate (GreenLEP): An in-depth look at the anatomical endoscopic enucleation of the prostate using a 532-nm lithium triborate laser.

Andrologia 2020 Jul 14:e13729. Epub 2020 Jul 14.

Department of Urology, Pasteur Clinic, Toulouse, France.

GreenLight laser enucleation of the prostate (GreenLEP) is an alternative endoscopic enucleation of the prostate (EEP) technique for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic obstruction (BPO). GreenLEP is an 'en bloc' EEP technique to remove the transitional zone tissue in one piece. The procedure is a combination of laser enucleation and blunt gentle mechanical dissection using the tip of the resectoscope. Read More

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http://dx.doi.org/10.1111/and.13729DOI Listing

Hematology and oncology clinical care during the coronavirus disease 2019 pandemic.

CA Cancer J Clin 2020 Jul 14. Epub 2020 Jul 14.

Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, New York.

New York City has been at the epicenter of the coronavirus disease 2019 (COVID-19) pandemic that has already infected over a million people and resulted in more than 70,000 deaths as of early May 2020 in the United States alone. This rapid and enormous influx of patients into the health care system has had profound effects on all aspects of health care, including the care of patients with cancer. In this report, the authors highlight the transformation they underwent within the Division of Hematology and Medical Oncology as they prepared for the COVID-19 crisis in New York City. Read More

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http://dx.doi.org/10.3322/caac.21627DOI Listing

Granulomatous lung disease: clinical aspects.

Expert Rev Respir Med 2020 Jul 14. Epub 2020 Jul 14.

Department of Medicine, Pulmonary and Critical Care Medicine, Albany Medical Center , NY, USA.

Introduction: Granulomatous lung diseases (GLD) are heterogenous group of diseases that can be broadly categorized as infectious or non-infectious. This distinction is extremely important, as the misdiagnosis of a GLD can have serious consequences. In this manuscript we describe the clinical manifestations, histopathology and diagnostic approach to GLD. Read More

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http://dx.doi.org/10.1080/17476348.2020.1794827DOI Listing

Correlation between sleep impairment and functional dyspepsia.

J Int Med Res 2020 Jul;48(7):300060520937164

College of Stomatology, Xi'an Medical University, Xi'an, Shaanxi Province, China.

Objective: Sleeping habits may greatly impact the prevalence of functional dyspepsia (FD). This study examined relationships between aspects of sleep impairment and FD.

Methods: This prospective study included university student volunteers. Read More

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http://dx.doi.org/10.1177/0300060520937164DOI Listing

The rising of allergic respiratory diseases in a changing world: from climate change to migration.

Expert Rev Respir Med 2020 Jul 14. Epub 2020 Jul 14.

Department of SOS Allergy and Clinical Immunology, USL Toscana Centro Prato , Italy.

Introduction: The rising of allergic respiratory diseases (ARDs) suggests a decisive role of environmental factors, that have dramatically changed in the last decades.

Areas Covered: This review addresses various aspects of the external exposome acting on the development, progression, clinical presentation and severity of ARDs. Climate change, air pollution and biodiversity loss act directly and through their complex interactions on atopic risk: reacent foundings on these aspects are discussed herein. Read More

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http://dx.doi.org/10.1080/17476348.2020.1794829DOI Listing

Guiding Lights: Tissue Bioprinting Using Photoactivated Materials.

Chem Rev 2020 Jul 14. Epub 2020 Jul 14.

Tissue Engineering + Biofabrication HPL J22, ETH Zürich, Otto-Stern-Weg 7, 8093 Zürich, Switzerland.

Photoactivated materials have found widespread use in biological and medical applications and are playing an increasingly important role in the nascent field of three-dimensional (3D) bioprinting. Light can be used as a trigger to drive the formation or the degradation of chemical bonds, leading to unprecedented spatiotemporal control over a material's chemical, physical, and biological properties. With resolution and construct size ranging from nanometers to centimeters, light-mediated biofabrication allows multicellular and multimaterial approaches. Read More

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http://dx.doi.org/10.1021/acs.chemrev.0c00077DOI Listing

Are there relevant animal models to set research priorities in LUTD? ICI-RS 2019.

Neurourol Urodyn 2020 Jul;39 Suppl 3:S9-S15

School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK.

Aim: To discuss animal models of lower urinary tract disorders (LUTD) and their translational impact.

Methods: Report of discussions based on presented literature-search based reviews relevant for the purpose.

Results: Animal models can be used to investigate fundamental biological mechanisms, but also as tools to elucidate aspects of the pathogenesis of disease and to provide early evidence of any safety risk. Read More

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http://dx.doi.org/10.1002/nau.24259DOI Listing

Cobalt-based heterogeneous catalysts in an electrolyzer system for sustainable energy storage.

Authors:
Anurupa Maiti

Dalton Trans 2020 Jul 14. Epub 2020 Jul 14.

Department of Chemistry, Indian Institute of Technology, Kharagpur-721302, India.

Nowadays, the production of hydrogen and oxygen focuses on renewable energy techniques and sustainable energy storage. A substantial challenge is to extend low-cost electrocatalysts consisting of earth-abundant resources, prepared by straightforward approaches that display high intrinsic activity compared to noble metals. The expansion of bifunctional catalysts in alkaline electrolytes for both the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) has become very crucial in recent times. Read More

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http://dx.doi.org/10.1039/d0dt01469aDOI Listing

The computational quantum mechanical study of sulfamide drug adsorption onto XY fullerene-like nanocages: detailed DFT and QTAIM investigations.

J Biomol Struct Dyn 2020 Jul 14:1-11. Epub 2020 Jul 14.

Department of Chemical Engineering, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.

In the current work, the adsorption of sulfamide drug onto the exterior surface of four fullerene-like nanocages, including AlN, AlP, BN, and BP was studied by employing density functional theory (DFT) and the quantum theory of atom in the molecule (QTAIM) calculations. Our calculations revealed that the sulfamide drug connects to the Al, B, P, and N atoms of AlN, AlP, BN, and BP nanocages through the oxygen and hydrogen atoms with releasing energies of -47.27, -34. Read More

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http://dx.doi.org/10.1080/07391102.2020.1792991DOI Listing

The Symbolic Meaning of HIV: Understanding Lecturers' Ambivalence over Teaching HIV to Dietetic Students.

J Int Assoc Provid AIDS Care 2020 Jan-Dec;19:2325958220939755

Department of Statistics, College of Arts and Sciences, Kansas State University, Manhattan, KS, USA.

Responding to the increasing reports of health students and professionals demonstrating stigmatized attitudes toward people living with HIV (PLHIV), this article examined the learning process that takes place during their academic training. Using symbolic interactionism as a theoretical framework, we studied the way lecturers in dietetic schools in Indonesia make meaning of their understanding and experience of HIV in relation to their teaching conduct. We found that the current curriculum does not provide adequate opportunities for students to learn and interact with PLHIV. Read More

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http://dx.doi.org/10.1177/2325958220939755DOI Listing

A randomized controlled trial of a smartphone-based application for the treatment of anxiety.

Psychother Res 2020 Jul 14:1-12. Epub 2020 Jul 14.

Department of Psychiatry, Stanford University, Stanford, CA, USA.

Generalized anxiety disorder (GAD) is prevalent among college students. Smartphone-based interventions may be a low-cost treatment method. College students with self-reported GAD were randomized to receive smartphone-based guided self-help ( = 50), or no treatment ( = 50). Read More

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http://dx.doi.org/10.1080/10503307.2020.1790688DOI Listing

Happiness at the End of Life: A Qualitative Study.

Am J Hosp Palliat Care 2020 Jul 14:1049909120939857. Epub 2020 Jul 14.

Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Background: Happiness is a core ingredient of health and well-being, yet relatively little is known about what happiness means for individuals near the end of life, and whether perceptions of happiness change as individuals approach the end of their lives.

Aim: The aim of this study was to explore, through interviews, how individuals experiencing hospice care understood and conceptualized happiness.

Design: Qualitative interviews with hospice patients were analyzed thematically. Read More

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http://dx.doi.org/10.1177/1049909120939857DOI Listing

A Mitochondria-Immobilized Unimolecular Fluorescent Probe for Multiplexing Imaging of Living Cancer Cells.

Anal Chem 2020 Jul 14. Epub 2020 Jul 14.

Cancer incidence and mortality are fast growing worldwide. Recently, multiplexing imaging methods have been reported to be vital for cancer diagnosis and therapy. Fluorescence imaging, which has intrinsic capabilities for multiplexing imaging, is suitable and ripe for cancer imaging. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c01046DOI Listing

Neurocognitive development and capabilities in boys with 49,XXXXY syndrome.

Am J Med Genet A 2020 Jul 14. Epub 2020 Jul 14.

Research Department, The Focus Foundation, Davidsonville, Maryland, USA.

49,XXXXY was previously associated with profound to severe intellectual deficits. However, prior research papers on the cognitive profiles of this population were confounded by small samples sizes, wide age spreads, and incomplete histories of testosterone replacement therapy. This study is the first comprehensive, international investigation of the neurocognitive aspects of 49,XXXXY, and the potential effects of biological treatment on this profile. Read More

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http://dx.doi.org/10.1002/ajmg.a.61736DOI Listing

Inclusion body myositis in the rheumatology clinic.

Int J Rheum Dis 2020 Jul 14. Epub 2020 Jul 14.

Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Inclusion body myositis is a rare sporadic inflammatory-degenerative myopathy of the elderly. Despite being the commonest type of acquired myopathy after the age of 50, misdiagnosis is extremely common. The most frequent hurdle in identifying new cases is the wrong diagnosis of polymyositis or motor neuron disease. Read More

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http://dx.doi.org/10.1111/1756-185X.13902DOI Listing

Breast cancer risk assessment and management programs: A practical guide.

Breast J 2020 Jul 14. Epub 2020 Jul 14.

Department of Surgery, Northwestern Memorial Hospital, Chicago, Illinois, USA.

Breast cancer risk assessment continues to evolve as emerging knowledge of breast cancer risk drivers and modifiers enables better identification of high-risk women who may benefit from increased screening or targeted risk-reduction protocols. The ongoing development of breast cancer Risk Assessment and Management Programs (RAMPs) presents an opportunity to decrease breast cancer disease incidence with evidence-based interventions. The goal of this review was to provide a practical guide for providers seeking to establish or update a breast cancer risk assessment and management program. Read More

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http://dx.doi.org/10.1111/tbj.13967DOI Listing

Cultured Beef: from small biopsy to substantial quantity.

J Sci Food Agric 2020 Jul 13. Epub 2020 Jul 13.

Mosa Meat B.V. Maastricht, Netherlands.

Cultured meat is an emerging technology with the potential to solve huge challenges related to the environmental, ethical and health implications of conventional meat production. Whilst establishing the basic science of cultured meat has been the primary focus of the last decade, it is now feasible that cultured meat products will enter the market within the next three to four years. This proximity to market introduction demands an evaluation of aspects of the cultured meat production process that have not yet been outlined or discussed in significant detail. Read More

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http://dx.doi.org/10.1002/jsfa.10663DOI Listing

Automatic collateral circulation scoring in ischemic stroke using 4D CT angiography with low-rank and sparse matrix decomposition.

Int J Comput Assist Radiol Surg 2020 Jul 14. Epub 2020 Jul 14.

Robarts Research Institute, Western University, London, Ontario, N6A 5B7, Canada.

Purpose: Sufficient collateral blood supply is crucial for favorable outcomes with endovascular treatment. The current practice of collateral scoring relies on visual inspection and thus can suffer from inter and intra-rater inconsistency. We present a robust and automatic method to score cerebral collateral blood supply to aid ischemic stroke treatment decision making. Read More

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http://dx.doi.org/10.1007/s11548-020-02216-wDOI Listing

Altered ANRIL Methylation in Epileptic Patients.

J Mol Neurosci 2020 Jul 13. Epub 2020 Jul 13.

Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Long non-coding RNAs (lncRNAs) have regulatory roles in several aspects of cellular physiology. Recent studies have also revealed their role in neuronal differentiation and the pathophysiology of neurologic disorders such as epilepsy. We have recently reported altered expression of a number of lncRNAs in the peripheral blood of epileptic patients in association with their response to antiepileptic drugs. Read More

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http://dx.doi.org/10.1007/s12031-020-01666-wDOI Listing

Chemotype variations among lichen ecotypes of Umbilicaria aprina as revealed by LC-ESI-MS/MS: a survey of antioxidant phenolics.

Environ Sci Pollut Res Int 2020 Jul 13. Epub 2020 Jul 13.

Institute of Chemistry of Rennes, ISCR, UMR CNRS 6226, University of Rennes 1, 2 Av. du Pr. Leon Bernard, 35043, Rennes Cedex, France.

In the present study, we characterized the phytochemical properties, which were specifically associated with phenolic compounds and antioxidant activities in six distinct ecotypes of Umbilicaria aprina Nyl. from Iran (including Kivarestan, Mishan, Takht-e Nader, Tochal, Sabalan, and Sahand) to detect diversities within the species. Total phenolic concentration (TPC) and radical scavenging capacities of U. Read More

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http://dx.doi.org/10.1007/s11356-020-10053-2DOI Listing

Pediatrician, watch out for corona-phobia.

Eur J Pediatr 2020 Jul 13. Epub 2020 Jul 13.

Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

The current outbreak of COVID-19 raging globally is taking a heavy toll on the adult population, with a rapidly growing number of newly infected and critically ill patients. However, to date, mortality rate among children is low as they mostly suffer from a mild disease. Yet, other more routinely encountered childhood diseases do not stand still and continue to be the main share of pediatricians' everyday challenges. Read More

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http://dx.doi.org/10.1007/s00431-020-03736-yDOI Listing

Validity and reliability of the Patient Health Questionnaire-8 in Swedish for individuals with systemic sclerosis.

Rheumatol Int 2020 Jul 13. Epub 2020 Jul 13.

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Stockholm, Sweden.

Background: Depressive symptoms are common in rheumatic diseases and influence patients' quality of life. The Patient Health Questionnaire-9 (PHQ-9), which assesses symptoms of depression, is valid in English in patients with systemic sclerosis (SSc). However, the measurement properties of the PHQ-8 (short version of the PHQ-9) have not been evaluated in Swedish patients with SSc. Read More

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http://dx.doi.org/10.1007/s00296-020-04641-1DOI Listing

[Gender-specific aspects of chronic coronary artery disease in everyday practice. Results of the AURORA health care study].

MMW Fortschr Med 2020 Jul 17;162(Suppl 5):21-27. Epub 2020 Jul 17.

GIM, Charité, Universitätsmedizin Berlin, Universitätsmedizin Zürich, Deutschland.

Background: Sex/gender differences pose a challenge in the care of patients with chronic coronary artery disease (CAD) especially in the resident sector. The aim of the AURORA trial was to obtain a nationwide overview on how resident cardiologists deal with sex/gender-specific aspects of symptomatic chronic CAD in their medical routine care and in the interplay with general practitioners, as well as derive insights out of it for general practice.

Method: Between October 2018 and April 2019 a survey among German cardiologists (n = 360) in the outpatient sector was performed using a structured questionnaire. Read More

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http://dx.doi.org/10.1007/s15006-020-0660-zDOI Listing

Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections.

Ann Intensive Care 2020 Jul 13;10(1):94. Epub 2020 Jul 13.

Dipartimento di Scienza dell'Emergenza, Anestesiologiche e della Rianimazione - UOC di Anestesia, Rianimazione, Terapia Intensiva e Tossicologia Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Rome, Italy.

Background: In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day) has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data are available. We designed a prospective observational study to describe the pharmacokinetic/pharmacodynamic (PK/PD) profile of HD TGC in a cohort of critically ill patients with severe infections.

Results: This was a single centre, prospective, observational study that was conducted in the 20-bed mixed ICU of a 1500-bed teaching hospital in Rome, Italy. Read More

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http://dx.doi.org/10.1186/s13613-020-00715-2DOI Listing

Association between habitual physical activity (HPA) and sleep quality in patients with cystic fibrosis.

Sleep Breath 2020 Jul 14. Epub 2020 Jul 14.

Department of Pulmonary Medicine, University Hospital Essen - Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Tueschener Weg 40, 45239, Essen, Germany.

Purpose: Sleep disturbances and poor sleep quality are known to be present in patients with CF. Regular physical activity plays an important role in the treatment of CF patients due to its positive influence on progression of disease and quality of life. The aim of this work is to create a home-based sleep and activity profile and to investigate the influence of habitual physical activity (HPA) on sleep quality in children, adolescents, and adults with CF. Read More

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http://dx.doi.org/10.1007/s11325-020-02130-0DOI Listing

Testing cardiovascular autonomic function in the COVID-19 era: lessons from Bologna's Autonomic Unit.

Clin Auton Res 2020 Jul 13. Epub 2020 Jul 13.

IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica NeuroMet, Ospedale Bellaria, Via Altura 3, 40139, Bologna, Italy.

The coronavirus disease 2019 (COVID-19) pandemic has changed the way most medical procedures are performed. Autonomic units, as well as other healthcare sectors, are required to undergo a thorough reorganization of the protocols in order to guarantee the safety of patients and healthcare staff. Cardiovascular autonomic function testing (CAFT) is necessary in certain situations; however, it poses several concerns which need to be addressed. Read More

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http://dx.doi.org/10.1007/s10286-020-00710-4DOI Listing

Increased phospholipase D activity contributes to tumorigenesis in prostate cancer cell models.

Mol Cell Biochem 2020 Jul 14. Epub 2020 Jul 14.

Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5246, ICBMS, 69622, Lyon, France.

Prostate cancer (PCa) is the most frequent cancer among men and the first cause of death over 65. Approximately 90% of patients with advanced disease will develop bone metastasis, which dramatically reduces long-term survival. Therefore, effective therapies need to be developed, especially when disease is still well-localized. Read More

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http://dx.doi.org/10.1007/s11010-020-03827-2DOI Listing

Current Status of Medical Therapy for Inflammatory Bowel Disease: The Wealth of Medications.

Dig Dis Sci 2020 Jul 13. Epub 2020 Jul 13.

Section of Gastroenterology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Previously, the natural history of Crohn's disease and ulcerative colitis included significant morbidity due to limited treatment options that were not without serious side effects. Early treatment options included corticosteroids as well as mesalamine, thiopurines, and methotrexate. In 1998, monoclonal antibodies to a key inflammatory cytokine, TNFα, became available. Read More

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http://dx.doi.org/10.1007/s10620-020-06471-4DOI Listing

Phacomatoses in the pediatric age group.

Childs Nerv Syst 2020 Jul 13. Epub 2020 Jul 13.

Centre of Neurofibromatosis at the Centre of Rare Diseases, Tübingen University Hospital, Tübingen, Germany.

The most common phacomatoses in children that need surgical attention are neurofibromatosis 1 and 2, tuberous sclerosis complex, Sturge-Weber disease, Von Hippel-Lindau disease, and neurocutaneous melanocytosis. All are rare and, as genetically determined disorders, all complex multisystem diseases with multiple manifestations outside the CNS. Diagnostics, management recommendations, and surgical care are age-specific and require individualization. Read More

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http://dx.doi.org/10.1007/s00381-020-04794-1DOI Listing