449,154 results match your criteria Aspects of Affect[Journal]


Statistical learning of speech regularities can occur outside the focus of attention.

Cortex 2019 Jan 28;115:56-71. Epub 2019 Jan 28.

Northwestern University, Department of Psychology, Evanston, IL, USA. Electronic address:

Statistical learning, the process of extracting regularities from the environment, plays an essential role in many aspects of cognition, including speech segmentation and language acquisition. A key component of statistical learning in a linguistic context is the perceptual binding of adjacent individual units (e.g. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.01.013DOI Listing
January 2019

Eosinophilic granuloma of the cervical spine in adults: A review.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Department of Orthodontics, Manipal College of Dental Sciences, Manipal Academy of Higher education, Manipal, India.

Purpose: Spinal eosinophilic granulomas(EGs) are uncommon tumors, constituting <1% of all bone tumors. They are mostly seen in the pediatric age group while adult onset is rare. Cervical spine is an infrequent location for involvement by EG. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.230DOI Listing
February 2019

Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital of Basel and University of Basel, Basel, Switzerland.

Background: Adjunctive systemic antibiotic therapy for treatment of bacterial endophthalmitis is controversial but common practice due to the severity of the disease. In absence of guidance documents, several antibiotic regimens are being used without applying evidence-based prescribing, thus leading to inappropriate treatment of this serious eye condition.

Objectives: To summarize available data on intravitreal penetration of systemically administered antibiotics and to discuss their usefulness from a microbiological and pharmacological point of view. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.017DOI Listing
February 2019

Fin whale (Balaenoptera physalus) mitogenomics: A cautionary tale of defining sub-species from mitochondrial sequence monophyly.

Mol Phylogenet Evol 2019 Feb 13. Epub 2019 Feb 13.

Marine Evolution and Conservation, Groningen Institute of Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands; Center for Coastal Studies, 5 Holway Avenue, Provincetown, MA 02657, United States of America. Electronic address:

The advent of massive parallel sequencing technologies has resulted in an increase of studies based upon complete mitochondrial genome DNA sequences that revisit the taxonomic status within and among species. Spatially distinct monophyly in such mitogenomic genealogies, i.e. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.02.003DOI Listing
February 2019

Dual Effect of Doxazosin: Anticancer Activity on SH-SY5Y Neuroblastoma Cells and Neuroprotection on an In Vitro Model of Alzheimer's Disease.

Neuroscience 2019 Feb 13. Epub 2019 Feb 13.

Programa de Pós-Graduação em Ciências Biológicas-Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Several studies have demonstrated the antitumor effect of doxazosin, an α1-adrenergic blocker, against glioma and breast, bladder and prostate cancers. Doxazosin is also being evaluated as a treatment for posttraumatic stress disorder and alcoholism, and α1-adrenergic blockers have been linked to neuroprotection in neurodegenerative disorders, such as Alzheimer's Disease (AD). Cancer and AD have an inverse relationship in many aspects, with several factors that contribute to apoptosis inhibition and proliferation being increased in cancers but decreased in AD. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.005DOI Listing
February 2019

Forms of extracellular mitochondria and their impact in health.

Mitochondrion 2019 Feb 13. Epub 2019 Feb 13.

Universidad San Francisco de Quito, Colegio de Ciencias de la Salud - Hospital de los Valles, Escuela de Medicina, Quito 17-12-841, Ecuador; Universidad San Francisco de Quito, Instituto de Investigaciones en Biomedicina, Quito 17-12-841, Ecuador; Mito-Act Research Consortium, Quito, Ecuador; Sistemas Médicos - Universidad San Francisco de Quito, SIME-USFQ, Quito 17-12-841, Ecuador. Electronic address:

Mitochondria play an important role as an intracellular energy plant and signaling organelle. However, mitochondria also exist outside cells where they could mediate cell-to-cell communication, repair and serve as an activator of the immune response. Their effects depend on the mitochondrial state or the form in which it is present, either as a whole functional structure as fragments or only as mitochondrial DNA. Read More

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http://dx.doi.org/10.1016/j.mito.2019.02.002DOI Listing
February 2019

Engineered microbial host selection for value-added bioproducts from lignocellulose.

Biotechnol Adv 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:

Lignocellulose is a rich and sustainable globally available carbon source and is considered a prominent alternative raw material for producing biofuels and valuable chemical compounds. Enzymatic hydrolysis is one of the crucial steps of lignocellulose degradation. Cellulolytic and hemicellulolytic enzyme mixes produced by different microorganisms including filamentous fungi, yeasts and bacteria, are used to degrade the biomass to liberate monosaccharides and other compounds for fermentation or conversion to value-added products. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.003DOI Listing
February 2019

Prenatal cannabinoid exposure and altered neurotransmission.

Neuropharmacology 2019 Feb 13. Epub 2019 Feb 13.

Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA. Electronic address:

Marijuana is one of the most commonly used illicit drugs worldwide. In addition, use of synthetic cannabinoids is increasing, especially among adolescents and young adults. Although human studies have shown that the use of marijuana during pregnancy leads to adverse behavioral effects, such as deficiencies in attention and executive function in affected offspring, the rate of marijuana use among pregnant women is steadily increasing. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.018DOI Listing
February 2019

Adult sex ratio as an index for male strategy in primates.

Theor Popul Biol 2019 Feb 13. Epub 2019 Feb 13.

School of Mathematics and Statistics, University of Sydney, Sydney, NSW 2006, Australia.

The adult sex ratio (ASR) is defined as the number of fertile males divided by the number of fertile females in a population. We build an ODE model with minimal age structure, in which males compete for paternities using either a multiple-mating or searching-then-guarding strategy, to investigate the value of ASR as an index for predicting which strategy males will adopt, with a focus in our investigation on the differences of strategy choice between chimpanzees (Pan troglodytes) and human hunter-gatherers (Homo sapiens). Parameters in the model characterise aspects of life history and behaviour, and determine both dominant strategy and the ASR when the population is at or near equilibrium. Read More

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http://dx.doi.org/10.1016/j.tpb.2019.02.002DOI Listing
February 2019

Characterization of aspirin esterase activity in health and disease: in vitro and ex vivo studies.

Biochem Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Due to its ability to irreversibly inactivate platelet cyclooxygenase, low-dose aspirin (ASA) is the most widely used antithrombotic agent. Although, studies in specific types of patients with cardiovascular disease (CVD) have shown an incomplete inhibition of platelet's cyclooxygenase, which may increase the variability in drug response. Some aspects of ASA pharmacokinetics (PK) still need further investigation. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.014DOI Listing
February 2019

Structural effects of variation in the human clavicle.

Am J Phys Anthropol 2019 Feb 16. Epub 2019 Feb 16.

Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

Objectives: Purported evolutionary shifts in shoulder structure have been linked to changes in hominin behavior and adaptation. Researchers use clavicle morphology to infer these shifts. However, there is a lack of empirical data underlying such predictive relationships. Read More

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http://dx.doi.org/10.1002/ajpa.23787DOI Listing
February 2019

Weak effects of geolocators on small birds: a meta-analysis controlled for phylogeny and publication bias.

J Anim Ecol 2019 Feb 16. Epub 2019 Feb 16.

The Czech Academy of Sciences, Institute of Vertebrate Biology, Květná 8, 603 65, Brno, Czech Republic.

Currently, the deployment of tracking devices is one of the most frequently used approaches to study movement ecology of birds. Recent miniaturisation of light-level geolocators enabled studying small bird species whose migratory patterns were widely unknown. However, geolocators may reduce vital rates in tagged birds and may bias obtained movement data. Read More

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http://dx.doi.org/10.1111/1365-2656.12962DOI Listing
February 2019

Measuring Mitochondrial Dysfunction Caused by Soluble α-Synuclein Oligomers.

Methods Mol Biol 2019 ;1948:183-198

Department of Neurology, Columbia University Medical Center, New York, NY, USA.

Accumulation of misfolded αSyn and mitochondrial dysfunction are central features of Parkinson's disease. Growing evidence points to a relationship between these two phenomena as oligomeric α-synuclein (αSyn) can interact with mitochondria and impair their function. Standardization of methods to prepare αSyn oligomers and isolate functional mitochondria will facilitate efforts to expand upon early findings. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_14DOI Listing
January 2019

Mathematical models applied to thyroid cancer.

Biophys Rev 2019 Feb 15. Epub 2019 Feb 15.

Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP, 18618-689, Brazil.

Thyroid cancer is the most prevalent endocrine neoplasia in the world. The use of mathematical models on the development of tumors has yielded numerous results in this field and modeling with differential equations is present in many papers on cancer. In order to know the use of mathematical models with differential equations or similar in the study of thyroid cancer, studies since 2006 to date was reviewed. Read More

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http://dx.doi.org/10.1007/s12551-019-00504-7DOI Listing
February 2019

Mozambique's Community Antiretroviral Therapy Support Group Program: The Role of Social Relationships in Facilitating HIV/AIDS Treatment Retention.

AIDS Behav 2019 Feb 15. Epub 2019 Feb 15.

The Lewis Family Foundation, Boston, MA, USA.

The Community Antiretroviral (ARV) Therapy Support Group (CASG) program aims to address low retention rates in Mozambique's HIV treatment program and the absorptive capacity of the country's health facilities. CASG provides patients with the opportunity to form groups, whose members provide peer support and collect ARV medications on a rotating basis for one another. Based on the promising results in one province, a multi-site level evaluation followed. Read More

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http://dx.doi.org/10.1007/s10461-019-02419-6DOI Listing
February 2019

F-FLT PET/MRI for bone marrow failure syndrome-initial experience.

EJNMMI Res 2019 Feb 15;9(1):16. Epub 2019 Feb 15.

Biomedical Imaging Research Center, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Fukui, 910-1193, Japan.

Background: Bone marrow failure syndrome (BMFS) is a heterogeneous group of disorders associated with single- or multiple-lineage cytopenia and failure of normal hematopoiesis. We assessed the feasibility of integrated PET/MRI with 3'-deoxy-3'-F-fluorothymidine (F-FLT) to assess the pathophysiology of whole-body bone marrow for the diagnosis and monitoring of BMFS. Twenty-five consecutive patients with BMFS underwent a pre-treatment F-FLT PET/MRI scan. Read More

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http://dx.doi.org/10.1186/s13550-019-0490-0DOI Listing
February 2019

Delivery Systems as Vital Tools in Drug Repurposing.

AAPS PharmSciTech 2019 Feb 15;20(3):116. Epub 2019 Feb 15.

Advanced Drug Delivery Laboratory, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, Ohio, 44272, USA.

The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment of crucial aspects of drug repurposing such as (i) maximizing the repurposed drug effects on a new target, (ii) minimizing off-target effects, (iii) modulating the release profiles of drug at the site of absorption, (iv) modulating the pharmacokinetics/in vivo biodistribution of the repurposed drug, (v) targeting/modulating drug retention at the sites of action, and (vi) providing a suitable platform for therapeutic application of combination drugs. Read More

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http://dx.doi.org/10.1208/s12249-019-1333-zDOI Listing
February 2019

Spatiotemporal gait analysis of older persons in clinical practice and research : Which parameters are relevant?

Authors:
Ulrich Lindemann

Z Gerontol Geriatr 2019 Feb 15. Epub 2019 Feb 15.

Department of Clinical Gerontology and Rehabilitation, Robert-Bosch-Hospital, Auerbachstr. 110, 70376, Stuttgart, Germany.

For older persons walking is a basic activity of daily life which characterizes the person's functional mobility. Therefore, the improvement of walking performance is a major clinical outcome during geriatric rehabilitation. Furthermore, walking performance is relevant for several geriatric research issues. Read More

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http://dx.doi.org/10.1007/s00391-019-01520-8DOI Listing
February 2019

Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer's disease pathogenesis.

Cell Mol Life Sci 2019 Feb 15. Epub 2019 Feb 15.

Centre of Excellence in Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, Australia.

Alzheimer's disease (AD) is a multifactorial age-related brain disease. Numerous pathological events run forth in the brain leading to AD. There is an initial long, dormant phase before the clinical symptoms become evident. Read More

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http://dx.doi.org/10.1007/s00018-019-03040-5DOI Listing
February 2019
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[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 Feb 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019

Cytokine-mediated communication: a quantitative appraisal of immune complexity.

Nat Rev Immunol 2019 Feb 15. Epub 2019 Feb 15.

Immunodynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Intercellular communication mediated by cytokines is the main mechanism by which cells of the immune system talk to each other. Many aspects of cytokine signalling in the immune system have been explored in great detail at the structural, biophysical, biochemical and cellular levels. However, a systematic understanding of the quantitative rules that govern cytokine-mediated cell-to-cell communication is still lacking. Read More

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http://dx.doi.org/10.1038/s41577-019-0131-xDOI Listing
February 2019

Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction.

Neuropsychopharmacology 2019 Feb 15. Epub 2019 Feb 15.

Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.

NETO1 and NETO2 are auxiliary subunits of kainate receptors (KARs). They interact with native KAR subunits to modulate multiple aspects of receptor function. Variation in KAR genes has been associated with psychiatric disorders in humans, and in mice, knockouts of the Grik1 gene have increased, while Grik2 and Grik4 knockouts have reduced anxiety-like behavior. Read More

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http://dx.doi.org/10.1038/s41386-019-0344-5DOI Listing
February 2019

Disciplinary boundaries and integrating care: using Q-methodology to understand trainee views on being a good doctor.

BMC Med Educ 2019 Feb 15;19(1):59. Epub 2019 Feb 15.

Cardiff University School of Postgraduate Medical and Dental Education, Cardiff, UK.

Background: Rising numbers of patients with multiple-conditions and complex care needs mean that it is increasingly important for doctors from different specialty areas to work together, alongside other members of the multi-disciplinary team, to provide patient centred care. However, intra-professional boundaries and silos within the medical profession may challenge holistic approaches to patient care.

Methods: We used Q methodology to examine how postgraduate trainees (n = 38) on a range of different specialty programmes in England and Wales could be grouped based on their rankings of 40 statements about 'being a good doctor'. Read More

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http://dx.doi.org/10.1186/s12909-019-1493-2DOI Listing
February 2019

Gut microbiota-dependent CCR9+CD4+ T cells are altered in secondary progressive multiple sclerosis.

Brain 2019 Feb 15. Epub 2019 Feb 15.

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, Japan.

The mechanism underlying the progression of relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis (SPMS), characterized by accumulating fixed disability, is yet to be fully understood. Although alterations in the gut microbiota have recently been highlighted in multiple sclerosis pathogenesis, the mechanism linking the altered gut environment with the remote CNS pathology remains unclear. Here, we analyse human CD4+ memory T cells expressing the gut-homing chemokine receptor CCR9 and found a reduced frequency of CCR9+ memory T cells in the peripheral blood of patients with SPMS relative to healthy controls. Read More

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http://dx.doi.org/10.1093/brain/awz012DOI Listing
February 2019

Divergent mitochondrial lineages arose within a large, panmictic population of the Savannah sparrow (Passerculus sandwichensis).

Mol Ecol 2019 Feb 15. Epub 2019 Feb 15.

Division of Biological Sciences, University of Montana, 32 Campus Dr. HS104, Missoula, MT, 59812.

Unusual patterns of mtDNA diversity can reveal interesting aspects of a species' biology. However, making such inferences requires discerning among the many alternative scenarios that could underlie any given mtDNA pattern. Next-generation sequencing methods provide large, multi-locus datasets with increased power to resolve unusual mtDNA patterns. Read More

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http://dx.doi.org/10.1111/mec.15049DOI Listing
February 2019

The roles of signaling pathways in liver repair and regeneration.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The liver has remarkable regeneration potency that restores liver mass and sustains body hemostasis. Liver regeneration through signaling pathways following resection or moderate damages are well studied. Various cell signaling, growth factors, cytokines, receptors, and cell types implicated in liver regeneration undergo controlled hypertrophy and proliferation. Read More

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http://dx.doi.org/10.1002/jcp.28336DOI Listing
February 2019

OMERACT Filter 2.1: Elaboration of the Conceptual Framework for Outcome Measurement in Health Intervention Studies.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit; Department of Medical Humanities, VU University Medical Centre/EMGO+ institute, Amsterdam, the Netherlands; Institute for Work & Health and Institute for Health Policy Management and Evaluation, University of Toronto, Toronto; Centre for Practice-Changing Research, Ottawa Hospital Research Institute; Cardiovascular Research Methods Centre, University of Ottawa Heart Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario; McGill Centre for Outcomes Research and Evaluation, Montreal, Quebec, Canada; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland; Medicine Service, VA Medical Center; Department of Medicine, School of Medicine, University of Alabama; Division of Epidemiology, School of Public Health, University of Alabama, Birmingham, Alabama; SDG LLC, Cambridge, Massachusetts; Division of Immunology/Rheumatology, Stanford University School of Medicine, Palo Alto, California, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Hôpital Ambroise Paré, Rheumatology Department, Boulogne-Billancourt; INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint- Quentin University, Saint-Quentin en Yvelines; Sorbonne Université; Pitié Salpêtrière hospital, AP-HP, Rheumatology Department, Paris, France; Sydney Medical School, Institute of Bone and Joint Research; Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia. DEB, COB III, PGC, MAD, MPD, LG, LM, LS, JAS, VS, GAW, and PT are members of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies. PGC is funded in part by the NIHR Leeds Biomedical Research Centre. The views expressed in this article are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. JAS is supported by the resources and use of the facilities at the VA Medical Center at Birmingham, Alabama, USA. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government. LM is a principal investigator on the Australian Rheumatology Association Database, which has received armslength funding from Pfizer Australia, AbbVie Australia, Eli Lilly Australia, and Janssen Australia. M. Boers, MD, PhD, Professor of Clinical Epidemiology, Amsterdam UMC, Vrije Universiteit Amsterdam; D.E. Beaton, PhD, Senior Scientist, Institute for Work & Health, and Associate Professor, Institute Health Policy, Management and Evaluation, University of Toronto; B.J. Shea, PhD, Senior Scientist, Ottawa Hospital Research Institute, Clinical Epidemiology Program, and School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa; L.J. Maxwell, PhD, University of Ottawa and Centre for Practice-Changing Research, Ottawa Hospital Research Institute; S.J. Bartlett, PhD, Professor of Medicine, McGill University, Centre for Outcomes Research and Evaluation, and Division of Rheumatology, Department of Medicine, Johns Hopkins University; C.O. Bingham III, MD, Division of Rheumatology, Department of Medicine, Johns Hopkins University; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M.A. D'Agostino, MD, PhD, AP-HP, Professor of Rheumatology, Hôpital Ambroise Paré, Rheumatology Department, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University; M.P. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; L. Gossec, MD, PhD, Sorbonne Universités, UPMC Univ Paris 06, and AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology; L. March, MBBS, PhD, Liggins Professor of Rheumatology and Musculoskeletal Epidemiology, Sydney Medical School, Institute of Bone and Joint Research, and Department of Rheumatology, Royal North Shore Hospital; J.A. Singh, MBBS, MPH, Professor of Medicine and Epidemiology, Department of Medicine at the School of Medicine, University of Alabama at Birmingham; L.S. Simon, MD, Co-Managing Director of SDG LLC; V. Strand, MD, Biopharmaceutical Consultant, Portola Valley, California, USA; G.A. Wells, MSc, PhD, Director, Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, and Professor, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, MSc, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute. Address correspondence to Dr. M. Boers, Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands. Accepted for publication December 6, 2018.

Objective: The Outcome Measures in Rheumatology (OMERACT) Filter 2.0 framework was developed in 2014 to aid core outcome set development by describing the full universe of "measurable aspects of health conditions" from which core domains can be selected. This paper provides elaborations and updated concepts (OMERACT Filter 2. Read More

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http://dx.doi.org/10.3899/jrheum.181096DOI Listing
February 2019

Consensus Building in OMERACT: Recommendations for Use of the Delphi for Core Outcome Set Development.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the University of Ottawa, Departments of Medicine and Innovation in Medical Education; Center for Global Health, University of Ottawa; Division of Rheumatology, Department of Medicine, School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute; Centre for Practice-Changing Research, Ottawa Hospital Research Institute; OMERACT, Ottawa; Institute for Work and Health, Toronto, Ontario; Department of Medicine, McGill University, Montreal, Quebec, Canada; University of Liverpool, Department of Biostatistics, COMET, Liverpool, UK; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Sydney Medical School, University of Sydney, Sydney; Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health; Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam, the Netherlands. S. Humphrey-Murto, Associate Professor of Medicine, MD, MEd, University of Ottawa, Departments of Medicine and Innovation in Medical Education; R. Crew, BSc (Hons), University of Liverpool, Department of Biostatistics, COMET; B. Shea, PhD, Center for Global Health, University of Ottawa; S.J. Bartlett, PhD, Professor, Department of Medicine, McGill University, and Adjunct Professor, Department of Medicine, Johns Hopkins University; L. March, MBBS, MSc, PhD, FRACP, FAFPHM, Sydney Medical School, University of Sydney, and Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health, and Department of Rheumatology, Royal North Shore Hospital; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; L.J. Maxwell, PhD, Centre for Practice-Changing Research, Ottawa Hospital Research Institute, and University of Ottawa; D. Beaton, BscOT, PhD, Senior Scientist, Institute for Work and Health; S. Grosskleg, OMERACT, and University of Ottawa; M. de Wit, PhD, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health. Address correspondence by Dr. S. Humphrey-Murto, The Ottawa Hospital-Riverside Campus, 1967 Riverside Dr., Ottawa, Ontario, K1H 7W9, Canada. E-mail: Accepted for publication December 6, 2018.

Objective: Developing international consensus on outcome measures for clinical trials is challenging. The following paper will review consensus building in Outcome Measures in Rheumatology (OMERACT), with a focus on the Delphi.

Methods: Based on the literature and feedback from delegates at OMERACT 2018, a set of recommendations is provided in the form of the OMERACT Delphi Consensus Checklist. Read More

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http://dx.doi.org/10.3899/jrheum.181094DOI Listing
February 2019

Advancing stiffness measurement in rheumatic disease: report from the Stiffness Special Interest group at OMERACT 2018.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From Johns Hopkins University School of Medicine, Baltimore, MD USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK; McGill University, Montreal, Quebec, Canada; Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA; Division of Medicine, The University of Adelaide, Adelaide, Australia Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia; Horizon Pharma, Inc, Lake Forest, Illinois, USA and Adjunct Professor, College of Pharmacy, University of Illinois, Chicago, IL, USA; Healthy Motivation, Bone and Joint Decade Global Alliance for Musculoskeletal Health, Santa Barbara, California, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Singapore General Hospital, Duke-NUS Medical School; University of Bristol, Bristol, UK; University of West England - Bristol, Bristol, UK. AMO is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. Work from the US Cohort was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under award numbers [P30-AR070254 Core B] and [P30-AR053503 Core D] and Patient Centered Outcomes Research Institute (PCORI) Pilot Project Award number [IP2-PI000737], and the Camille Julia Morgan Arthritis Research and Education Fund. All statements in this report including its conclusions are the opinions of the authors and do not necessarily reflect those of PCORI, its board of governors, or its methodology committee, or of NIH or NIAMS. RH is an employee of Horizon Pharma, LLC; CK is an employee of Janssen Scientific Affairs, LLC. Address correspondence to Ethan T Craig, 3900 Woodland Ave., Philadelphia, PA 19104. Email:

Objective: To improve measurement of stiffness in rheumatic disease.

Methods: Data presented included: 1) Two qualitative projects; 2) The RA Stiffness patient-reported outcome measure (RAST); 3) three items assessing stiffness severity, duration, and interference. 3) RESULTS: Stiffness is multidimensional and includes aspects of stiffness experience such as duration, severity, and impact. Read More

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http://dx.doi.org/10.3899/jrheum.181074DOI Listing
February 2019

FT modulates genome-wide DNA-binding of the bZIP transcription factor FD.

Plant Physiol 2019 Feb 15. Epub 2019 Feb 15.

Umeå Plant Science Centre, Department of Plant Physiology, Umeå University CITY: Umeå Sweden [SE]

The transition to flowering is a crucial step in the plant life cycle that is controlled by multiple endogenous and environmental cues, including hormones, sugars, temperature, and photoperiod. Permissive photoperiod induces the expression of FLOWERING LOCUS T (FT) in the phloem companion cells (PCC) of leaves. The FT protein then acts as a florigen that is transported to the shoot apical meristem (SAM), where it physically interacts with the bZIP transcription factor FD and 14-3-3 proteins. Read More

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http://dx.doi.org/10.1104/pp.18.01505DOI Listing
February 2019

Immune challenge-induced oxidative damage may be mitigated by biliverdin.

J Exp Biol 2019 Feb 15. Epub 2019 Feb 15.

Department of Biology, Lafayette College, Easton, PA 18042, USA

An effective immune response results in the elimination of pathogens, but this immunological benefit may be accompanied by increased levels of oxidative damage. However, organisms have evolved mechanisms to mitigate the extent of such oxidative damage, including the production and mobilization of antioxidants. One potential mechanism of mitigating immune-challenge-induced changes in oxidative physiology is increasing biliverdin production. Read More

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http://dx.doi.org/10.1242/jeb.200055DOI Listing
February 2019

Control of invasive sea lampreys using the piscicides TFM and niclosamide: Toxicology, successes & future prospects.

Aquat Toxicol 2018 Dec 21. Epub 2018 Dec 21.

Department of Biology & Laurier Institute for Water Science, Wilfrid Laurier University, Waterloo, Ontario, N2L 3C5, Canada.

The invasion of the Laurentian Great Lakes of North America by sea lampreys (Petromyzon marinus) in the early 20th century contributed to the depletion of commercial, recreational and culturally important fish populations, devastating the economies of communities that relied on the fishery. Sea lamprey populations were subsequently controlled using an aggressive integrated pest-management program which employed barriers and traps to prevent sea lamprey from migrating to their spawning grounds and the use of the piscicides (lampricides) 3-trifluoromethyl-4-nitrophenol (TFM) and niclosamide to eliminate larval sea lampreys from their nursery streams. Although sea lampreys have not been eradicated from the Great Lakes, populations have been suppressed to less than 10% of their peak numbers in the mid-1900s. Read More

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http://dx.doi.org/10.1016/j.aquatox.2018.12.012DOI Listing
December 2018

Membrane penetration and trapping of an active particle.

J Chem Phys 2019 Feb;150(6):064906

Institut für Theoretische Physik II: Weiche Materie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.

The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues. During their cellular uptake, the particles can pass through cell membranes via passive endocytosis or by active penetration to reach a target cellular compartment or organelle. In this manuscript, we develop a simple model to describe the interaction of a self-driven spherical particle (moving through an effective constant active force) with a minimal membrane system, allowing for both penetration and trapping. Read More

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http://dx.doi.org/10.1063/1.5080807DOI Listing
February 2019

Quantum dynamics and spectroscopy of dihalogens in solid matrices. II. Theoretical aspects and G-MCTDH simulations of time-resolved coherent Raman spectra of Schrödinger cat states of the embedded IKr cluster.

J Chem Phys 2019 Feb;150(6):064112

Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 7, D-60438 Frankfurt am Main, Germany.

This study presents quantum dynamical simulations, using the Gaussian-based multiconfigurational time-dependent Hartree (G-MCTDH) method, of time-resolved coherent Raman four-wave-mixing spectroscopic experiments for the iodine molecule embedded in a cryogenic crystal krypton matrix [D. Picconi et al., J. Read More

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http://dx.doi.org/10.1063/1.5082651DOI Listing
February 2019

Vibronically and spin-orbit coupled diabatic potentials for X(P) + CH → HX + CH reactions: General theory and application for X(P) = F(P).

J Chem Phys 2019 Feb;150(6):064102

Theoretische Chemie, Fakultät für Chemie, Universität Bielefeld, Universitätsstraße 25, D-33615 Bielefeld, Germany.

An approach to systematically construct vibronically and spin-orbit coupled diabatic potential energy surfaces (PESs) for X(P) + CH → HX + CH reactions is proposed. Permutational symmetry and permutational invariants of the S group and its S and S × S subgroups are used to construct a diabatic model which properly describes the reaction starting from reactants to products. As a first example, the approach is applied to the construction of diabatic potentials for the F(P) + CH → HF + CH reaction. Read More

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http://dx.doi.org/10.1063/1.5063907DOI Listing
February 2019

Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inteleukin-3 (IL-3) have long been known as mediators of emergency myelopoiesis, but recent evidence has highlighted their critical role in modulating innate immune effector functions in mice and humans. This new wealth of knowledge has uncovered novel aspects of the pathogenesis of a range of disorders, including infectious, neoplastic, autoimmune, allergic and cardiovascular diseases. Consequently, GM-CSF and IL-3 are now being investigated as therapeutic targets for some of these disorders, and some phase I/II clinical trials are already showing promising results. Read More

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http://dx.doi.org/10.3390/ijms20040834DOI Listing
February 2019

On the Person-Place Interaction and Its Relationship with the Responses/Outcomes of Listeners of Urban Soundscape (Compared Cases of Lisbon and Bogotá): Contextual and Semiotic Aspects.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Instituto Superior Técnico, University of Lisbon, 1049-001 Lisboa, Portugal.

Design, planning, and management of the urban soundscape require various interacting fields of knowledge given the fact that it is the human person that experiences and provides meaning to the urban places and their acoustic environments. The process of environmental perception involves contextual information that conditions people's responses and outcomes through the relationship between the variables Person, Activity, and Place. This research focuses on the interaction between Person and Place and its impact on responses and outcomes from listeners with different geographical origin and background. Read More

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http://dx.doi.org/10.3390/ijerph16040551DOI Listing
February 2019

The Passo Fundo Cohort Study: design of a population-based observational study of women in premenopause, menopausal transition, and postmenopause.

Womens Midlife Health 2015 18;1:12. Epub 2015 Dec 18.

3Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS Brazil.

Background: The Passo Fundo Cohort Study (PFS) is a population-based longitudinal observational study of pre-, peri-, and postmenopausal women that has been ongoing since 1995 in Passo Fundo, a city in southern Brazil. This paper describes the rationale and design of the PFS and summarizes objectives and procedures that have been updated during follow-up.

Methods/design: Women in the PFS have been followed for a variety of diseases that are frequent in menopause. Read More

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http://dx.doi.org/10.1186/s40695-015-0013-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298002PMC
December 2015

Malnutrition as a Fall Risk Factor.

Fed Pract 2017 Feb;34(2):27-30

is a research registered dietitian nutritionist and clinical coordinator of diabetes education; is a nurse researcher and advanced practice nurse; is an administrative systems dietitian; and is the director of the statistical resource center for the Geriatric Research Education and Clinical Center, all at the Louis Stokes Cleveland VAMC in Ohio. Dr. Burant is an assistant professor at the Frances Payne Bolton School of Nursing, and is an assistant professor in the department of nutrition, both at Case Western Reserve University in Cleveland, Ohio.

Examining various aspects of malnutrition in elderly patients may be helpful in determining the risk of falls. Read More

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February 2017

First Report of Fusarium Head Blight on Winter Wheat in the Grand Duchy of Luxembourg.

Plant Dis 2008 Nov;92(11):1587

Department Sciences et Gestion de l'Environnement, Université de Liège, B-6700 Arlon, Belgium.

Following a comparatively mild winter (1.9°C above average [2000-2007]), Fusarium head blight (FHB) on winter wheat was observed during the 2007 season in 17 sites representing all three districts of Diekirch, Grevenmacher, and Luxembourg. The cultivars encountered were diverse and included Achat, Akteur, Aron, Bussard, Cubus, Enorm, Exclusiv, Flair, Rosario, Tommi, and Urban. Read More

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http://dx.doi.org/10.1094/PDIS-92-11-1587ADOI Listing
November 2008

Catecholamines can mediate stress-related effects on tumor progression.

Expert Rev Endocrinol Metab 2008 Nov;3(6):699-703

c Department of Molecular Virology, Immunology and Medical Genetics; Comprehensive Cancer Center; Department of Internal Medicine; Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus, OH 43210, USA.

Studies have implicated behavior as a factor that can influence several aspects of health and have described the complex bidirectional interactions among the CNS, the endocrine system and the immune system that are involved. There is evidence that psychological factors can affect the incidence and progression of some cancers in humans. The hypothesis that stress could be a cofactor is supported by data obtained from animal models. Read More

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http://dx.doi.org/10.1586/17446651.3.6.699DOI Listing
November 2008

Novel insights into FOXOlogy: FOXOs and their putative role in thyroid carcinogenesis.

Expert Rev Endocrinol Metab 2011 Jan;6(1):63-69

a Clinic of Endocrinology and Nephrology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, D-04103 Leipzig, Germany.

FOXO transcription factors regulate genes directly involved in the control of cell cycle arrest, apoptosis, DNA damage repair and antioxidative defense mechanisms. Genetic FOXO alterations and inactivation of FOXOs through oncogenic signaling cascades have been identified in several human cancers and contribute to uncoordinated cellular proliferation. To date, little is known about FOXOs in the thyroid context. Read More

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http://dx.doi.org/10.1586/eem.10.70DOI Listing
January 2011

Transthyretin: roles in the nervous system beyond thyroxine and retinol transport.

Expert Rev Endocrinol Metab 2012 Mar;7(2):181-189

a Molecular Neurobiology, IBMC- Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, 823, 4150-180, Porto, Portugal.

Transthyretin (TTR) is a plasma- and cerebrospinal fluid-circulating protein. Besides the primordially attributed systemic role as a transporter molecule of thyroxine (T) and retinol (through the binding to retinol-binding protein [RBP]), TTR has been recognized as a protein with important functions in several aspects of the nervous system physiology. TTR has been shown to play an important role in behavior, cognition, amidated neuropeptide processing and nerve regeneration. Read More

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http://dx.doi.org/10.1586/eem.12.2DOI Listing

Increasing the Chances of Natural Conception: Opinion Statement from the the Brazilian Federation of Gynecology and Obstetrics Associations Committee on Endocrine Gynecology.

Rev Bras Ginecol Obstet 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medical Sciences, Universidade de Pernambuco, Recife, PE, Brazil.

Considering that myths and misconceptions regarding natural procreation spread rapidly in the era of easy access to information and to social networks, adequate counseling about natural fertility and spontaneous conception should be encouraged in any kind of health assistance. Despite the fact that there is no strong-powered evidence about any of the aspects related to natural fertility, literature on how to increase the chances of a spontaneous pregnancy is available. In the present article, the Brazilian Federation of Gynecology and Obstetrics Associations (FEBRASGO, in the Portuguese acronym) Committee on Endocrine Gynecology provides suggestions to optimize counseling for non-infertile people attempting spontaneous conception. Read More

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http://dx.doi.org/10.1055/s-0039-1677838DOI Listing
February 2019

Native aortic valve derived extracellular matrix hydrogel for three dimensional culture analyses with improved biomimetic properties.

Biomed Mater 2019 Feb 15. Epub 2019 Feb 15.

Research Group for Experimental Surgery, Department of Cardiovascular Surgery, Medical Faculty, Heinrich Heine University Duesseldorf,, Düsseldorf, GERMANY.

Introduction Calcific aortic valve disease (CAVD) is the most common acquired heart valve disease with complex underlying pathomechanisms that are yet not fully understood. Three-dimensional (3D) cell culture models as opposed to conventional two-dimensional (2D) techniques may reveal new aspects of CAVD and serve as a transitional platform between conventional 2D cell culture and in vivo experiments. Methods Here we report on fabrication and characterization of a novel 3D hydrogel derived from cell-free native aortic valves. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0791DOI Listing
February 2019

Hydro air abrasion on dental glass-ceramics: A direct 3D analysis by stylus profilometry.

J Mech Behav Biomed Mater 2019 Feb 4;93:36-42. Epub 2019 Feb 4.

DISC Department, Genoa Dental School, Genoa University, Italy.

Air abrasion is used in dentistry for cavity opening, post-endodontic cavity cleaning, and removal of hard deposits or stains. Different applications may require different settings. We aimed to gain better understanding of the effect of some operating parameters on the efficiency of air abrasion on a model dental material. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.005DOI Listing
February 2019

Calcium Dobesilate and Micro-vascular diseases.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; Department of Internal Medicine and Diagnostics, Xuzhou Medical University, Xuzhou 221002, China. Electronic address:

Micro-vascular diseases and its associated complications continue to be a significant health problem worldwide. Vascular lesions from microvascular involvement lead to impaired blood flow and contribute to damage and dysfunction of one or more target organs, that is, the heart, kidneys, eyes, and nervous system. Calcium Dobesilate Drug (CAD) is an established vasoactive and angioprotective drug that has shown a unique, multitarget mode of action in several experimental studies and in different animal models of diabetic microvascular complications. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.023DOI Listing
February 2019

Rationally designed DNA-based nanocarriers.

Adv Drug Deliv Rev 2019 Feb 12. Epub 2019 Feb 12.

CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Nanomaterials employed for enhanced drug delivery and therapeutic effects have been extensively investigated in the past decade. The outcome of current anticancer treatments based on conventional nanoparticles is suboptimal, due to the lack of biocompatibility, the deficient tumor targeting, the limited drug accumulation in the diseased region, etc. Alternatively, DNA-based nanocarriers have emerged as a novel and versatile platform to integrate the advantages of nanotechnologies and biological sciences, which shows great promise in addressing the key issues for biomedical studies. Read More

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http://dx.doi.org/10.1016/j.addr.2019.02.003DOI Listing
February 2019

Parasites of Gymnodactylus darwinii Gray, 1845 (Squamata, Phyllodactylidae) from an Atlantic Rainforest fragment.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Programa de Pós-Graduação em Ecologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil; Programa de Pós-Graduação em Ciência Animal Tropical, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil; Laboratório de Parasitologia (LAPAR), Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil. Electronic address:

Gymnodactylus darwinii is an endemic lizard from Atlantic Rainforest. Ecological aspects of your parasitic fauna are still unknown. Therefore, the goal of the present study was to know the composition of parasitic fauna of G. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.010DOI Listing
February 2019