453,361 results match your criteria Aspects of Affect[Journal]


School-level factors associated with obesity: A systematic review of longitudinal studies.

Obes Rev 2019 Apr 23. Epub 2019 Apr 23.

Department of Child & Family Studies, College of Behavioral & Community Sciences, University of South Florida, Tampa, Florida.

Although school has been an important intervention venue for obesity prevention, the role of school-level factors in obesity development or prevention has not been well-documented. This study aimed to systematically examine the current evidence on school-level factors associated with obesity outcomes in longitudinal studies. The literature search was performed in PubMed, EMBASE, CINHAL, and PsycINFO. Read More

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http://dx.doi.org/10.1111/obr.12852DOI Listing

[Evaluation of diagnostic and management concepts of anaphylaxis in non-allergist physicians in Colombia].

Rev Alerg Mex 2019 Jan-Mar;66(1):18-26

Universidad de Antioquía, Grupo de Alergología Clínica y Experimental, Antioquía, Colombia.

Background: Several reports show deficiencies in the knowledge of physicians about the diagnostic criteria and the treatment of anaphylaxis, a condition that can have fatal consequences.

Objective: To evaluate the knowledge of physicians in Colombia on the fundamental aspects of anaphylaxis in diagnosis and treatment.

Methods: Analytical cross-sectional study, carried out through a survey of 11 questions that evaluate clinical aspects of anaphylaxis, addressed to general practitioners and specialists in different health areas resident in Colombia. Read More

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http://dx.doi.org/10.29262/ram.v66i1.524DOI Listing

Effects of hydrogen-rich water in a rat model of polycystic kidney disease.

PLoS One 2019 23;14(4):e0215766. Epub 2019 Apr 23.

Department of Nephrology, Faculty of Medicine, Saga University, Saga, Japan.

Various factors are considered to be mechanisms of the increase in the sizes of cysts in patients with polycystic kidney disease. Vasopressin is one of the causes, and drinking large volumes of water shows an effect of suppressing an increase in cysts. On the other hand, it is known that hydrogen-rich water reduces oxidative stress and has a good effect on kidney injury. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215766PLOS

Properties of face localizer activations and their application in functional magnetic resonance imaging (fMRI) fingerprinting.

PLoS One 2019 23;14(4):e0214997. Epub 2019 Apr 23.

University Department of Psychiatry and Psychotherapy, University Hospital Tuebingen, Tuebingen, Germany.

Functional localizers are particularly prevalent in functional magnetic resonance imaging (fMRI) studies concerning face processing. In this study, we extend the knowledge on face localizers regarding four important aspects: First, activation differences in occipital and fusiform face areas (OFA/FFA) and amygdala are characterized by increased activation while precuneus and medial prefrontal cortex show decreased deactivation to faces versus control stimuli. The face-selective posterior superior temporal sulcus is a hybrid area exhibiting increased activation within its inferior and decreased deactivation within its superior part. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214997PLOS

In memoriam of Marvin Zuckerman: His impact on Spanish Psychology.

Authors:
Anton Aluja

Psicothema 2019 May;31(2):184-193

University of Lleida. Catalonia (Spain) and Lleida Institute for Biomedical Research Dr. Pifarré Foundation (IRBLleida).

Background: The work of recently deceased Marvin Zuckerman is well-known in Psychology. Zuckerman is mainly known around the world for describing the nature of the Sensation Seeking personality trait (with a strong biological basis related to physiology, endocrinology, brain biochemistry and genetics), and its practical usefulness in explaining many human behaviors, especially high-risk behaviors.

Method: The article refers to biographical aspects of Zuckerman’s career, and presents and presents an outline of results produced in Spain within the Zuckerman framework. Read More

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http://dx.doi.org/10.7334/psicothema2019.35DOI Listing

Dynamics of Liquid Transfer from Nanoporous Stamps in High-Resolution Flexographic Printing.

Langmuir 2019 Apr 23. Epub 2019 Apr 23.

Printing of ultrathin layers of polymeric and colloidal inks is critical for the manufacturing of electronics on non-conventional substrates such as paper and polymer films. Recently, we found that nanoporous stamps overcome key limitations of traditional polymer stamps in flexographic printing, namely enabling the printing of ultrathin nanoparticle films with micron-scale lateral precision. Here, we study the dynamics of liquid transfer between nanoporous stamps and solid substrates. Read More

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http://dx.doi.org/10.1021/acs.langmuir.9b00460DOI Listing

Mass transport analysis of bicarbonate buffer: Effect of the CO-HCO hydration-dehydration kinetics in the fluid boundary layer and the apparent effective pKa controlling dissolution of acids and bases.

Mol Pharm 2019 Apr 23. Epub 2019 Apr 23.

The main buffering system influencing ionizable drug dissolution in the human intestinal fluid is bicarbonate-based; however, it is rarely used in routine pharmaceutical practice due to the volatility of dissolved CO. The typical pharmaceutical buffers used fail to capture the unique aspects of the hydration-dehydration kinetics of the bicarbonate-CO system. In particular, CO is involved in a reversible interconversion with carbonic acid (HCO), which is the actual conjugate acid of the system, as follows (CO + HO ⇌ HCO). Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00187DOI Listing

Prediction of orthosteric and allosteric regulations on cannabinoid receptors using supervised machine learning classifiers.

Mol Pharm 2019 Apr 23. Epub 2019 Apr 23.

Designing highly selective compounds to protein subtypes, and developing allosteric modulators targeting them are critical considerations to both drug discovery and mechanism studies for cannabinoid receptors. It is challenging but in demand to have classifiers to identify active ligands from inactive or random compounds, and distinguish allosteric modulators from orthosteric ligands. In this study, supervised machine learning classifiers were built for two subtypes of cannabinoid receptors, CB1 and CB2. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00182DOI Listing

Characterizing Polymer-Grafted Nanoparticles: From Basic Defining Parameters to Behavior in Solvents and Self-Assembled Structures.

Anal Chem 2019 Apr 23. Epub 2019 Apr 23.

Polymer-grafted nanoparticles, often called hairy nanoparticles (HNPs), are an intriguing class of nanostructured hybrid materials with great potential in a variety of applications, including advanced polymer nanocomposite fabrication, drug delivery, imaging, and lubrication. This Feature Article provides an introduction to characterization of various aspects of HNPs, from basic defining parameters to behavior of HNPs in solvents and self-assembled structures of multicomponent brush nanoparticles, by using a broad range of analytical tools. Read More

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http://dx.doi.org/10.1021/acs.analchem.9b00707DOI Listing

Recent perspectives on the virulent factors and treatment options for multidrug-resistant Acinetobacter baumannii.

Crit Rev Microbiol 2019 Apr 23:1-19. Epub 2019 Apr 23.

a Department of Biotechnology , Dayananda Sagar College of Engineering , Bangalore , India.

Acinetobacter baumannii (AB) is one of the most notorious and opportunistic pathogens, which caused high morbidity and mortality rate and World Health Organization (WHO) declared this bacterium as priority-1 pathogen in 2017. The current antibacterial agents, such as colistins, carbapenems, and tigecyclines have limited applications, which necessitate novel and alternative therapeutic remedies. Thus, the understanding of recent perspectives on the virulent factors and antibiotic resistance mechanism exhibited by the bacteria are extremely important. Read More

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http://dx.doi.org/10.1080/1040841X.2019.1600472DOI Listing

Psychosocial and physical adjustments and prosthesis satisfaction in amputees: a systematic review of observational studies.

Disabil Rehabil Assist Technol 2019 Apr 23:1-8. Epub 2019 Apr 23.

c Production Engineering , Federal University of Santa Catarina , Florianópolis , Brazil.

Background: Adjustment to amputation is a complex process because it encompasses physical and psychosocial aspects as well as satisfaction with the artificial limb.

Purpose: To review the scientific production on psychosocial and physical adjustments to amputation and prosthesis use as well as prosthetic satisfaction in people with lower limb amputation in the last 10 years.

Methods: This review was conducted on the MEDLINE via Pubmed, Web of Science and Scopus databases. Read More

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http://dx.doi.org/10.1080/17483107.2019.1602853DOI Listing

The language and communication attributes of graphic symbol communication aids - a systematic review and narrative synthesis.

Disabil Rehabil Assist Technol 2019 Apr 23:1-11. Epub 2019 Apr 23.

a Faculty of Health, Psychology and Social Care , Manchester Metropolitan University , Manchester , UK.

Background: Symbol communication aids are used by children with little or no intelligible speech as an Augmentative and Alternative Communication strategy. Graphic symbols are used to help support understanding of language and used in symbol communication aids to support expressive communication. The decision making related to the selection of a symbol communication aid for a child is poorly understood and little is known about what language and communication attributes are considered in this selection. Read More

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http://dx.doi.org/10.1080/17483107.2019.1604828DOI Listing

Addressing a Need for Valid Measures of Trait Reactance in Adolescents: A Further Test of the Hong Psychological Reactance Scale.

J Pers Assess 2019 Apr 23:1-13. Epub 2019 Apr 23.

a Centro de Investigação em Psicologia para o Desenvolvimento , Instituto de Psicologia e de Ciências da Educação, Universidade Lusíada-Norte (Porto) , Portugal.

Research is scant concerning the developmental aspects of trait reactance. If measures are not validated for use across different age groups, it is difficult for researchers to investigate the specificities of reactance across the life span. So far, the factor structure and psychometric properties of the Hong Psychological Reactance Scale (HPRS) have not been tested in adolescents. Read More

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http://dx.doi.org/10.1080/00223891.2019.1585360DOI Listing

Recent Advances on Electrochemical Sensors for the Detection of Organic Disinfection Byproducts in Water.

ACS Sens 2019 Apr 23. Epub 2019 Apr 23.

College of Engineering , Swansea University , Bay Campus, Swansea SA1 8EN , United Kingdom.

Irreversible organ damage or even death frequently occurs when humans or animals unknowingly drink contaminated water. Therefore, in many countries drinking water is disinfected to ensure removal of harmful pathogens from drinking water. If upstream water treatment prior to disinfection is not adequate, disinfection byproducts (DBPs) can be formed. Read More

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http://dx.doi.org/10.1021/acssensors.9b00272DOI Listing

Chronic calorie-dense diet drives differences in motivated food seeking between obesity-prone and resistant mice.

Addict Biol 2019 Apr 22:e12753. Epub 2019 Apr 22.

Department of Medical Neurobiology, Faculty of Medicine, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Israel.

Obesity results from overconsumption of energy, partly because of the inability to refrain from highly palatable rewarding foods. Even though palatable food is available to everyone, only a fraction of the population develops obesity. We previously showed that following chronic exposure to highly palatable food animals that gained the most weight also showed addictive-like motivation to seek for palatable food. Read More

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http://dx.doi.org/10.1111/adb.12753DOI Listing

Chemical, Structural, and Electronic Aspects of Formation and Degradation Behavior on Different Length Scales of Ni-Rich NCM and Li-Rich HE-NCM Cathode Materials in Li-Ion Batteries.

Adv Mater 2019 Apr 23:e1900985. Epub 2019 Apr 23.

Institute for Applied Materials-Energy Storage Systems (IAM-ESS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.

In order to satisfy the energy demands of the electromobility market, both Ni-rich and Li-rich layered oxides of NCM type are receiving much attention as high-energy-density cathode materials for application in Li-ion batteries. However, due to different stability issues, their longevity is limited. During formation and continuous cycling, especially the electronic and crystal structure suffers from various changes, eventually leading to fatigue and mechanical degradation. Read More

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http://dx.doi.org/10.1002/adma.201900985DOI Listing

Euthymia in Diabetes: Clinical Evidence and Practice-Based Opinion from an International Expert Group.

Diabetes Ther 2019 Apr 22. Epub 2019 Apr 22.

Department of Diabetology & Internal Medicine, Medical university of Warsaw, Warsaw, Poland.

Aim: To develop an evidence-based expert group opinion on various types of euthymia associated with diabetes mellitus (DM) and its management.

Background: Diabetes mellitus is a metabolic syndrome characterized by diverse biomedical and psychosocial features. Emotional health disturbances may lead to psychological and psychiatric dysfunction and may negatively influence glycemic control. Read More

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http://link.springer.com/10.1007/s13300-019-0614-6
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http://dx.doi.org/10.1007/s13300-019-0614-6DOI Listing
April 2019
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Habit2: A stand-alone software solution for presenting stimuli and recording infant looking times in order to study infant development.

Behav Res Methods 2019 Apr 22. Epub 2019 Apr 22.

Department of Child Development, University of California, Sacramento, CA, USA.

Many aspects of infant development are assessed using infant looking times to visual and audiovisual stimuli. In this article, we describe a stand-alone software package that allows simultaneous stimulus presentation to infants and recording of their looking times via a keypress by a human observer. The software was developed to run both on 64-bit Intel-based Macs running Mac OS/X 10. Read More

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http://link.springer.com/10.3758/s13428-019-01244-y
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http://dx.doi.org/10.3758/s13428-019-01244-yDOI Listing
April 2019
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Mobile health ethics and the expanding role of autonomy.

Med Health Care Philos 2019 Apr 22. Epub 2019 Apr 22.

Institute of Ethics, History and Theory of Medicine, Ludwig-Maximilians-Universität München, Lessingstraße 2, 80336, Munich, Germany.

Mhealth technology is mushrooming world-wide and, in a variety of forms, reaches increasing numbers of users in ever-widening contexts and virtually independent from standard medical evidence assessment. Yet, debate on the broader societal impact including in particular mapping and classification of ethical issues raised has been limited. This article, as part of an ongoing empirically informed ethical research project, provides an overview of ethical issues of mhealth applications with a specific focus on implications on autonomy as a key notion in the debate. Read More

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http://dx.doi.org/10.1007/s11019-019-09900-yDOI Listing

Acute Lung Injury: IL-17A-Mediated Inflammatory Pathway and Its Regulation by Curcumin.

Inflammation 2019 Apr 22. Epub 2019 Apr 22.

Yenepoya Research Centre, Yenepoya University, Deralakatte, Mangalore, Karnataka, 575018, India.

Acute lung injury (ALI) is characterized by acute inflammation and tissue injury results in dysfunction of the alveolar epithelial membrane. If the epithelial injury is severe, a fibroproliferative phase of ALI can develop. During this phase, the activated fibroblast and myofibroblasts synthesize excessive collagenous extracellular matrix that leads to a condition called pulmonary fibrosis. Read More

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http://dx.doi.org/10.1007/s10753-019-01010-4DOI Listing

Cancer cell-nanomaterial interface: role of geometry and surface charge of nanocomposites in the capture efficiency and cell viability.

Biomater Sci 2019 Apr 23. Epub 2019 Apr 23.

The Institute for Translational Nanomedicine, Shanghai East Hospital, the Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, P. R. China.

The nanomaterial-cell interface plays an important role in biodetection and therapy. Several parameters involved in the bio-nano interaction such as size, shape, surface charge, surface functionality and protein corona on the nanomaterials have been studied. Recently, we found that the surface charge of the cancer cell membrane derived from the glycolysis could be a general hallmark for cancer cell targeting and very efficient isolation by tailored nanoparticles. Read More

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http://dx.doi.org/10.1039/c9bm00037bDOI Listing

Fibrinogen and fibrin: An illustrated review.

Res Pract Thromb Haemost 2019 Apr 4;3(2):161-172. Epub 2019 Mar 4.

Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill North Carolina.

Since its discovery over 350 years ago, studies of fibrinogen have revealed remarkable characteristics. Its complex structure as a large (340 kDa) hexameric homodimer supports complex roles in hemostasis and homeostasis. Fibrinogen synthesis is regulated at the transcriptional and translational levels, undergoing both constitutive (basal) secretion from liver, and inducible upregulation in response to inflammatory events. Read More

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http://doi.wiley.com/10.1002/rth2.12191
Publisher Site
http://dx.doi.org/10.1002/rth2.12191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462751PMC
April 2019
1 Read

Evaluation of oxidative stress and the microenvironment in oral submucous fibrosis.

Heliyon 2019 Apr 12;5(4):e01502. Epub 2019 Apr 12.

School of Medical Science and Technology, IIT Kharagpur, India.

Background: Oral Submucous fibrosis (OSF) is a chronic inflammatory mucosal disease of unknown etiology. Statistics show cases of OSF which has a high rate of overall prevalence and increase the chance of malignant transformation. As we know malignant cells is situated in a very complex microenvironment with altered metabolic pathway including intermediates which participate in oxidative stress process which enhances metabolic rewiring and promotes tumor progression. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462775PMC

Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer's Disease.

Aging Dis 2019 Apr 1;10(2):383-403. Epub 2019 Apr 1.

1Washington Institute for Health Sciences, Arlington, VA 22203, USA.

Alzheimer's disease (AD) is a complex, multifactorial disease involving many pathological mechanisms. Nonetheless, single pathogenic mutations in amyloid precursor protein (APP) or presenilin 1 or 2 can cause AD with almost all of the clinical and neuropathological features, and therefore, we believe an important mechanism of pathogenesis in AD could be revealed from examining pathogenic APP missense mutations. A comprehensive review of the literature, including clinical, neuropathological, cellular and animal model data, was conducted through PubMed and the databases of Alzforum mutations, HGMD, UniProt, and AD&FTDMDB. Read More

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http://dx.doi.org/10.14336/AD.2018.0425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457050PMC

Impulsive-Compulsive Behaviours in Belgian-Flemish Parkinson's Disease Patients: A Questionnaire-Based Study.

Parkinsons Dis 2019 18;2019:7832487. Epub 2019 Mar 18.

Department of Neurology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium.

Background: Impulsive-compulsive behaviours (ICB) are a potentially harmful group of behavioural symptoms among the nonmotor aspects of Parkinson's disease (PD).

Objective: To develop and perform partial validation of a Belgian-Flemish version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP) as a screening instrument for ICB in PD patients.

Methods: Using a translation-backtranslation method, we developed a Belgian-Flemish version of the QUIP, which was subsequently completed by 88 PD patients. Read More

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http://dx.doi.org/10.1155/2019/7832487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442308PMC

Subjective Cognitive Decline in the Community Is Affected at Multiple Aspects of Mental Health and Life Quality: A Cross-Sectional Study of the Community Medicine of Keelung Chang Gung Memorial Hospital.

Dement Geriatr Cogn Dis Extra 2019 Jan-Apr;9(1):152-162. Epub 2019 Mar 13.

Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan.

Background: Subjective cognitive decline (SCD) is one of the early warning signs of objective cognition impairment and dementia.

Methods: This cross-sectional study screened SCD and studied multiple domains of mental health, lifestyle, and life quality of the community-dwelling people in the northern coastal region of Taiwan.

Results: Among 426 valid AD8 questionnaires, a cutoff of score 2 divided subjects into 115 with SCD (SCD+) and 311 without SCD (SCD-). Read More

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http://dx.doi.org/10.1159/000497222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465714PMC

New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin.

Cancer Cell Int 2019 11;19:92. Epub 2019 Apr 11.

1Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032 China.

Aim Of The Review: In the past decade, increasing research attention investigated the novel therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its main active constituent Bufalin have been studied in vitro, in vivo and clinical studies. This review aims to summarize the multi-target and multi-pathway pharmacological effects of Bufalin and Huachansu in the last decade, with the aim of providing a more comprehensive view and highlighting the recently discovered molecular mechanisms. Read More

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http://dx.doi.org/10.1186/s12935-019-0806-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458819PMC

How Does ISO 15189 Laboratory Accreditation Support the Delivery of Healthcare in Ethiopia? A Systematic Review.

Ethiop J Health Sci 2019 Mar;29(2):259-264

University of Gondar, College of Medicine and Health Sciences, School of Biomedical and Laboratory Sciences, Unit of Quality Assurance and Laboratory Management.

Background: Assessing quality by considering input, process and output level quality variables is important to ensure improved quality services. Designing and execution of an effective quality management system are aimed for the purpose of quality improvement, error reduction and associated risks. Therefore, this review is designed to assess the value of accreditation on the performance of healthcare institutions in ensuring quality improvement interventions. Read More

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http://dx.doi.org/10.4314/ejhs.v29i2.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460445PMC

Histological analysis of the anterolateral ligament of the knee.

J Orthop 2019 Sep-Oct;16(5):368-372. Epub 2019 Apr 8.

Department of Orthopaedic Surgery and Traumatology, University of Turin, "Città della salute e della scienza"-CTO Hospital of Turin, Turin, ITA, Italy.

Anterolateral ligament (ALL) was recently described as an important structure to control the pivot-shift phenomenon in the knee. Doubts remain regarding its origin and histological properties. The purpose of this study was to identify the ALL histological structure comparing its characteristics with those of the anterior cruciate ligament (ACL) and joint capsule. Read More

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http://dx.doi.org/10.1016/j.jor.2019.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463743PMC

Oral health related quality of life and determinant factors in patients with head and neck cancer.

Med Oral Patol Oral Cir Bucal 2019 Apr 23. Epub 2019 Apr 23.

Rua Baraúnas 351 Bairro Universitário -Campina Grande Paraíba, Brazil Postal code: 58429-500

Background: The present study aimed to measure the impact of oral health on the quality of life of patients with head and neck cancer.

Material And Methods: A cross-sectional study was conducted with 130 patients diagnosed with head and neck cancer at two medical centers. Participants answered a sociodemographic questionnaire and the Oral Health Impact Profile - 14 (OHIP-14). Read More

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http://dx.doi.org/10.4317/medoral.22670DOI Listing

A Scoping Review: Social Participation as a Cornerstone of Successful Aging in Place among Rural Older Adults.

Geriatrics (Basel) 2018 Oct 29;3(4). Epub 2018 Oct 29.

Centre for Disability Research and Policy, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW 2141, Australia.

Despite obstacles, many rural-dwelling older adults report that positive aspects of rural residence, such as attachment to community, social participation, and familiarity, create a sense of belonging that far outweighs the negative. By being part of a community where they are known and they know people, rural elders continue to find meaning, the key to achieving successful aging in this last stage of life. This scoping review explored factors influencing social participation and, through it, successful aging among rural-dwelling older adults. Read More

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http://www.mdpi.com/2308-3417/3/4/75
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http://dx.doi.org/10.3390/geriatrics3040075DOI Listing
October 2018
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Screening Methods for Age-Related Hearing Loss in Older Patients with Cancer: A Review of the Literature.

Geriatrics (Basel) 2018 Aug 2;3(3). Epub 2018 Aug 2.

Cancer Centre, Department of Medical Oncology, General Hospital Groeninge, B-8500 Kortrijk, Belgium.

As people grow older, they may experience loss in hearing sensitivity. Age-related hearing loss may negatively affect the patient's quality of life as it may lead to social isolation. In older patients with cancer, hearing loss can seriously interfere with the patient's ability to deal properly with all aspects of their disease, and may have a cumulative effect on their already decreased quality of life. Read More

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http://dx.doi.org/10.3390/geriatrics3030048DOI Listing

The Burden of Dysphagia on Family Caregivers of the Elderly: A Systematic Review.

Geriatrics (Basel) 2018 Jun 10;3(2). Epub 2018 Jun 10.

Communication Disorders and Sciences, University of Oregon, Eugene, OR 97403, USA.

With the rapid increase in the elderly population, there is a simultaneous increased need for care provided by family caregivers. Research in the field of head and neck cancer has indicated that caring for patients with dysphagia can impact a caregiver's quality of life. Given that many older adults present with dysphagia, one can assume that their caregivers are equally, if not more greatly, affected. Read More

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http://dx.doi.org/10.3390/geriatrics3020030DOI Listing

Understanding The Genetic Code.

Authors:
Milton H Saier

J Bacteriol 2019 Apr 22. Epub 2019 Apr 22.

Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0116

The universal triple nucleotide genetic code is often viewed as a given, randomly selected through evolution. However, as summarized in this article, many observations and deductions within structural and thermodynamic frameworks help to explain the forces that must have shaped the code during the early evolution of life on Earth. In this minireview, many revealing aspects of the "universal" genetic code are described and discussed. Read More

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http://jb.asm.org/lookup/doi/10.1128/JB.00091-19
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http://dx.doi.org/10.1128/JB.00091-19DOI Listing
April 2019
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Cost Comparison of an On-Premise IT Solution with a Cloud-Based Solution for Electronic Health Records in a Dental School Clinic.

J Dent Educ 2019 Apr 22. Epub 2019 Apr 22.

Lynn Johnson is Professor and Associate Dean, University of Michigan School of Dentistry; Cassandra Callaghan is Director of Dental Informatics, University of Michigan School of Dentistry; Madhan Balasubramanian is Sidney Sax National Health and Medical Research Council Research Fellow, University of Sydney, Australia and King's College London, United Kingdom; Haris Haq is a Consultant, Collaboration for Health IT; and Heiko Spallek is Professor, Head of School, and Dean, The University of Sydney School of Dentistry, Sydney, New South Wales, Australia.

Electronic health records (EHRs) are increasingly moving towards cloud-based web environments. While cloud-based EHRs claim substantial benefits at reduced cost, little cost-benefit research exists for dental schools. The aim of this study was to examine the cost-benefits of a cloud-based EHR compared to an on-premise client-server EHR in the University of Michigan School of Dentistry (U-M Dent). Read More

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http://dx.doi.org/10.21815/JDE.019.089DOI Listing

Function and Mechanism of Long Noncoding RNAs in Adipocyte Biology.

Diabetes 2019 May;68(5):887-896

Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, MI

The last two decades have witnessed an explosion of interest in adipocyte biology, coinciding with the upsurge of obesity and metabolic syndrome. Now we have new perspectives on the distinct developmental origins of white, brown, and beige adipocytes and their role in metabolic physiology and disease. Beyond fuel metabolism, adipocytes communicate with the immune system and other tissues by releasing diverse paracrine and endocrine factors to orchestrate adipose tissue remodeling and maintain systemic homeostasis. Read More

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http://dx.doi.org/10.2337/dbi18-0009DOI Listing

Functional Implications of DNA Methylation in Adipose Biology.

Authors:
Xiang Ma Sona Kang

Diabetes 2019 May;68(5):871-878

Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA

The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role in regulating whole-body metabolism and energy homeostasis (1). Accumulating evidence indicates that multiple aspects of adipose biology are regulated, in part, by epigenetic mechanisms. Read More

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http://dx.doi.org/10.2337/dbi18-0057DOI Listing

PROTEIN CHIMERIZATION: A NEW FRONTIER FOR ENGINEERING PROTEIN THERAPEUTICS WITH IMPROVED PHARMACOKINETICS.

J Pharmacol Exp Ther 2019 Apr 22. Epub 2019 Apr 22.

National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar (Mohali;

With the advancement of medicine, the utility of proteins therapeutic is increasing exponentially. However, a significant number of protein therapeutics suffer from grave limitations, which includes their subpar pharmacokinetics. Here, we have reviewed the emerging field of protein chimerization for improving the short circulatory half-life of protein therapeutics. Read More

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http://dx.doi.org/10.1124/jpet.119.257063DOI Listing

[New insights in the pathogenesis of pulmonary arterial hypertension].

Rev Mal Respir 2019 Apr 19. Epub 2019 Apr 19.

Inserm UMR_S 999, hôpital Marie Lannelongue, 133, avenue de la Résistance, 92350 Le Plessis-Robinson, France; Faculté de Médecine, université Paris-Sud, université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France. Electronic address:

Pulmonary arterial hypertension (PAH) is a severe and incurable cardiopulmonary disorder. Research from the past 10 years illustrates the complex and multifactorial aspects of PAH pathophysiology. Furthermore, latest advances in the field have led to a better understanding of the key components underlying this inadequate accumulation of pulmonary vascular cells within the pulmonary arterial walls, leading to pulmonary vascular remodelling. Read More

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http://dx.doi.org/10.1016/j.rmr.2019.03.003DOI Listing

An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses.

Radiother Oncol 2019 Apr 19. Epub 2019 Apr 19.

Department of Radiation Oncology, University of California, Irvine, United States.

For decades the field of radiation oncology has sought to improve the therapeutic ratio through innovations in physics, chemistry, and biology. To date, technological advancements in image guided beam delivery techniques have provided clinicians with their best options for improving this critical tool in cancer care. Medical physics has focused on the preferential targeting of tumors while minimizing the collateral dose to the surrounding normal tissues, yielding only incremental progress. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01678140193015
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http://dx.doi.org/10.1016/j.radonc.2019.03.028DOI Listing
April 2019
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Reoperative surgery for nonresponders and complicated sleeve gastrectomy operations in patients with severe obesity. An international expert panel consensus statement to define best practice guidelines.

Surg Obes Relat Dis 2019 Feb 15;15(2):173-186. Epub 2018 Nov 15.

Advanced Laparoscopic Surgery Associates, Fresno, California.

Background: Laparoscopic sleeve gastrectomy (SG) has rapidly become the most commonly performed bariatric procedure in the United States as well as other countries, with approximately 120,000 procedures being performed annually in the United States. Reoperative interventions after SG have become more prevalent in the past few years since the initial development of SG as a primary operation. Given the expected rapid growth of these reinterventions, an expert consensus conference was held with some of the most experienced bariatric surgeons in the world to better understand, discuss, and provide consensus on the reasons, indications, contraindications, and surgical options for nonresponders and complicated SG operations. Read More

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http://dx.doi.org/10.1016/j.soard.2018.11.006DOI Listing
February 2019

Brain size growth in Australopithecus.

Authors:
Zachary Cofran

J Hum Evol 2019 May 20;130:72-82. Epub 2019 Mar 20.

Anthropology Department, Vassar College, 124 Raymond Avenue, Box 42, Poughkeepsie, NY 12603, USA. Electronic address:

Postnatal growth is one of the proximate means by which humans attain massive adult brain size. Humans are characterized by the maintenance of prenatal brain growth rates into the first postnatal year, as well as an overall extended period of growth. The evolution of this pattern is difficult to assess due to its relatively brief duration and the underrepresentation of well-preserved fossil individuals who died during this short period. Read More

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http://dx.doi.org/10.1016/j.jhevol.2019.02.006DOI Listing

Tools, trails and time: Debating Acheulian group size at Attirampakkam, India.

J Hum Evol 2019 May 28;130:109-125. Epub 2019 Mar 28.

Sharma Centre for Heritage Education, 28, I Main Road, C.I. T Colony, Mylapore, Chennai 600004, Tamil Nadu, India.

Estimating Acheulian group sizes based on a fragmentary archaeological record is fraught with difficulties, more so in regions like India, where lithics form the primary source of information. Here, we review current approaches towards modeling group size in Indian archaeology. We then examine to what extent one may address issues related to seasonality, fission-fusion strategies and group size in the context of Acheulian sites, drawing on our research along the southeastern coast of India. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00472484183019
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http://dx.doi.org/10.1016/j.jhevol.2019.02.004DOI Listing
May 2019
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Research Techniques Made Simple: Mouse Models of Atopic Dermatitis.

J Invest Dermatol 2019 May 19;139(5):984-990.e1. Epub 2019 Apr 19.

Cutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:

Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by impaired barrier function, eczematous dermatitis, and chronic pruritus. Mouse models have been heavily used to deepen our understanding of complicated disease mechanisms in AD and to provide a preclinical platform before performing clinical interventional research on novel therapeutic agents in humans. However, what aspects of human AD these mouse AD models faithfully recapitulate is insufficiently understood. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.014DOI Listing

Compartmentalization of self-representations in female survivors of sexual abuse and assault, with posttraumatic stress disorder (PTSD).

Psychol Med 2019 Apr 23:1-8. Epub 2019 Apr 23.

Medical Research Council Cognition and Brain Sciences Unit,University of Cambridge,15 Chaucer Road, Cambridge, CB2 7EF,UK.

Background: This study examined the structure of the self-concept in a sample of sexual trauma survivors with posttraumatic stress disorder (PTSD) compared to healthy controls using a self-descriptive card-sorting task. We explored whether individuals with PTSD possess a highly affectively-compartmentalized self-structure, whereby positive and negative self-attributes are sectioned off into separate components of self-concept (e.g. Read More

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http://dx.doi.org/10.1017/S0033291719000837DOI Listing

PRODIGE 7 should be interpreted with caution.

Acta Chir Belg 2019 Apr 23:1-13. Epub 2019 Apr 23.

c Department of Medical Oncology , Institut Jules Bordet, Université Libre de Bruxelles , Brussels , Belgium.

The recent presentation and abstract from the PRODIGE 7 study at ASCO 2018 on the role of hyperthermic intraperitoneal chemotherapy (HIPEC) using oxaliplatin as adjuvant treatment following cytoreductive surgery (CRS) in patients with colorectal peritoneal metastases (PM) who have received perioperative chemotherapy (PCT) has shaken the surgical community involved in the treatment of colorectal PM. Since then, two papers, an editorial and an opinion paper, have been reported in response to the results from PRODIGE 7 with opposite conclusions and perspectives. In this debate paper, we focus on methodological aspects of the PRODIGE 7 trial by pointing out several weaknesses of the study, such as inclusion criteria (PCI >16) and the power calculation, in an effort to highlight our perspective that these results should be interpreted with caution and in the context of objective information in the current literature. Read More

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The impact of age on risk assessment, therapeutic practice and outcome in candidemia.

Infect Dis (Lond) 2019 Apr 23:1-10. Epub 2019 Apr 23.

a Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet , Oslo , Norway.

Background: In Norway, the epidemiological situation of candidemia is followed closely. We have previously demonstrated the highest incidence of candidemia in elderly >65 years of age. However, knowledge of other aspects of this infection is lacking. Read More

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http://dx.doi.org/10.1080/23744235.2019.1595709DOI Listing

"All Eyes on Me": A Qualitative Study of Parent and Patient Experiences of Multidisciplinary Care in Craniofacial Conditions.

Cleft Palate Craniofac J 2019 Apr 22:1055665619842730. Epub 2019 Apr 22.

1 Centre for Rare Disorders, Oslo University Hospital (Rikshospitalet), Oslo, Norway.

Objective: The present study investigated how adults with congenital craniofacial anomalies (CFAs) and parents experience the long-term and complex treatment offered by a multidisciplinary team (MDT).

Design: Exploratory-descriptive qualitative study based on individual semistructured interviews.

Setting: Centralized national follow-up and treatment of CFAs by a multidisciplinary craniofacial team from which participants were systematically recruited. Read More

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http://dx.doi.org/10.1177/1055665619842730DOI Listing

[Analysis of the utilization of one-day surgery in Hungary].

Orv Hetil 2019 Apr;160(17):670-678

Egészségbiztosítási Intézet, Pécsi Tudományegyetem, Egészségtudományi Kar Pécs, Mária utca 7., 7621.

The impact of one-day surgery has been increasing since the past few decades. This type of health service could fulfil many requirements of health policy, health care services, governments as well as patients. The aim of the research was to assess the publicly financed case numbers and interventions of one-day surgery in Hungary between 2010 and 2015 from different aspects. Read More

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http://dx.doi.org/10.1556/650.2019.31342DOI Listing