201 results match your criteria Asian journal of urology[Journal]


Application of fluorescence hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population.

Asian J Urol 2019 Jan 8;6(1):114-121. Epub 2018 Jun 8.

Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Objective: To evaluate the diagnostic value of fluorescence hybridization (FISH) in bladder cancer.

Methods: We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008. Receiver operating characteristic (ROC) curve analysis was performed and the area under curve (AUC) values were calculated for both the FISH and urine cytology tests. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363605PMC
January 2019
3 Reads

Detection of androgen receptor (AR) and AR-V7 in small cell prostate carcinoma: Diagnostic and therapeutic implications.

Asian J Urol 2019 Jan 28;6(1):109-113. Epub 2018 Sep 28.

Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objective: Small cell prostate carcinoma (SCPC) is a rare and highly malignant subtype of prostate cancer. SCPC frequently lacks androgen receptor (AR) and prostate-specific antigen (PSA) expression, and often responds poorly to androgen deprivation therapy (ADT). AR splice variant-7 (AR-V7) is a truncated AR protein implicated in resistance to AR-targeting therapies. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363596PMC
January 2019
1 Read

Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer.

Asian J Urol 2019 Jan 28;6(1):99-108. Epub 2018 Nov 28.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Localized prostate cancer is curable via annihilation of the entire cancer neighborhood by surgery or local radiation. Unfortunately, once metastatic, no available therapy is curative. The vast majority will die despite aggressive systemic combinational androgen-ablation therapies. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363604PMC
January 2019

Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer.

Asian J Urol 2019 Jan 28;6(1):91-98. Epub 2018 Nov 28.

Department of Pathology, Duke University School of Medicine, Durham, NC, USA.

Since androgen receptor (AR) signaling is critically required for the development of prostate cancer (PCa), targeting AR axis has been the standard treatment of choice for advanced and metastatic PCa. Unfortunately, although the tumor initially responds to the therapy, treatment resistance eventually develops and the disease will progress. It is therefore imperative to identify the mechanisms of therapeutic resistance and novel molecular targets that are independent of AR signaling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183009
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http://dx.doi.org/10.1016/j.ajur.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363598PMC
January 2019
2 Reads

Prostate tumor neuroendocrine differentiation via EMT: The road less traveled.

Asian J Urol 2019 Jan 17;6(1):82-90. Epub 2018 Nov 17.

Department of Urology, University of Kentucky College of Medicine, Lexington, KY, USA.

The long-standing challenge in the treatment of prostate cancer is to overcome therapeutic resistance during progression to lethal disease. Aberrant transforming-growth factor-β (TGF-β) signaling accelerates prostate tumor progression in a transgenic mouse model via effects on epithelial-mesenchymal transition (EMT), and neuroendocrine differentiation driving tumor progression to castration-resistant prostate cancer (CRPC). Neuroendocrine prostate cancer (NEPC) is highly aggressive exhibiting reactivation of developmental programs associated with EMT induction and stem cell-like characteristics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183008
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http://dx.doi.org/10.1016/j.ajur.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363600PMC
January 2019
3 Reads

Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics.

Asian J Urol 2019 Jan 28;6(1):65-81. Epub 2018 Nov 28.

Uro-Oncology Research, Department of Medicine and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

This article describes cell signaling network of metastatic prostate cancer (PCa) to bone and visceral organs in the context of tumor microenvironment and for the development of novel therapeutics. The article focuses on our recent progress in the understanding of: 1) The plasticity and dynamics of tumor-stroma interaction; 2) The significance of epigenetic reprogramming in conferring cancer growth, invasion and metastasis; 3) New insights on altered junctional communication affecting PCa bone and brain metastases; 4) Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy; 5) Genetic-based therapy to co-target tumor and bone stroma; 6) PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis; 7) The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis; and 8) Characterization of imprinting cluster of microRNA, in tumor-stroma interaction. This article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical translation. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363607PMC
January 2019
1 Read

Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier.

Asian J Urol 2019 Jan 15;6(1):57-64. Epub 2018 Sep 15.

Department of Urology, University of Wisconsin-Madison, Madison, WI, USA.

Androgen deprivation therapy (ADT) has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer (PCa). However, this approach is rarely curative. Recent clinical trials have demonstrated that ADT combined with other agents, notably docetaxel and abiraterone, lead to improved survival. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363606PMC
January 2019

Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer.

Asian J Urol 2019 Jan 26;6(1):50-56. Epub 2018 Sep 26.

Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Prostate cancer (PCa) growth and progression rely on the interaction between the androgen receptor (AR) and the testicular ligands, testosterone and dihydrotestosterone (DHT). Almost all men with advanced PCa receive androgen deprivation therapy (ADT). ADT lowers circulating testosterone levels, which impairs AR activation and leads to PCa regression. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363635PMC
January 2019

Current strategies for targeting the activity of androgen receptor variants.

Asian J Urol 2019 Jan 29;6(1):42-49. Epub 2018 Sep 29.

Department of Urology, University of California, Davis, Sacramento, CA, USA.

Current therapies for advanced prostate cancer, such as enzalutamide and abiraterone, focus on inhibiting androgen receptor (AR) activity and reducing downstream signaling pathways to inhibit tumor growth. Unfortunately, cancer cells are very adaptable and, over time, these cells develop mechanisms by which they can circumvent therapeutics. One of the many mechanisms that have been discovered is the generation of AR variants. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363599PMC
January 2019

Metastatic prostate cancer remains incurable, why?

Asian J Urol 2019 Jan 29;6(1):26-41. Epub 2018 Nov 29.

The Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Metastatic prostate cancer patients present in two ways-with already disseminated disease at the time of presentation or with disease recurrence after definitive local therapy. Androgen deprivation therapy is given as the most effective initial treatment to patients. However, after the initial response, almost all patients will eventually progress despite the low levels of testosterone. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363601PMC
January 2019
4 Reads

If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease.

Asian J Urol 2019 Jan 12;6(1):10-25. Epub 2018 Dec 12.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Antibodies are employed ubiquitously in biomedical sciences, including for diagnostics and therapeutics. One of the most important uses is for immunohistochemical (IHC) staining, a process that has been improving and evolving over decades. IHC is useful when properly employed, yet misuse of the method is widespread and contributes to the "reproducibility crisis" in science. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363603PMC
January 2019
1 Read

Current progress and questions in germline genetics of prostate cancer.

Asian J Urol 2019 Jan 2;6(1):3-9. Epub 2018 Nov 2.

North Shore University Health System, Research Institute, Evanston, IL, USA.

Dramatic progress has been made in the area of germline genetics of prostate cancer (PCa) in the past decade. Both common and rare genetic variants with effects on risk ranging from barely detectable to outright practice-changing have been identified. For men with high risk PCa, the application of genetic testing for inherited pathogenic mutations is becoming standard of care. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363602PMC
January 2019

In honor of Dr. Donald S. Coffey - Prostate cancer biology and therapy.

Asian J Urol 2019 Jan 3;6(1):1-2. Epub 2018 Nov 3.

Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

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http://dx.doi.org/10.1016/j.ajur.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363597PMC
January 2019

Indications and contraindications for shock wave lithotripsy and how to improve outcomes.

Asian J Urol 2018 Oct 4;5(4):256-263. Epub 2018 Sep 4.

Division of Urology, St. Michael's Hospital, Toronto, Canada.

For over 35 years shock wave lithotripsy has proven to be an effective, safe and truly minimally invasive option for the treatment of nephrolithiasis. Various technical factors as well as patient selection can impact the success of the procedure. We used published work focusing on outcomes of shock wave lithotripsy, risk of complications, and strategies for improving stone fragmentation to create this review. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183007
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http://dx.doi.org/10.1016/j.ajur.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197584PMC
October 2018
10 Reads

Retrograde intrarenal surgery: An expanding role in treatment of urolithiasis.

Asian J Urol 2018 Oct 22;5(4):264-273. Epub 2018 Jun 22.

Department of Urology, Tenon Hospital, Assistance-Publique Hôpitaux de Paris, Paris, France.

During the past 3 decades, the surgical management of kidney stones has undergone many technological advances and one is the development of the flexible ureteroscopy. The development of this instrument as well as ancillary equipment such as baskets, graspers, and others, and improvements in lithotripsy with Holmium: YAG laser have led to expand its indications with diagnostic and therapeutic management of medical issues of the upper urinary tract such as urolithiasis and urothelial tumors. The objective of this review is to describe its indications and results in the different scenarios for the treatment of urinary stones. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183005
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http://dx.doi.org/10.1016/j.ajur.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197554PMC
October 2018
8 Reads

Medical therapy for nephrolithiasis: State of the art.

Asian J Urol 2018 Oct 3;5(4):243-255. Epub 2018 Sep 3.

Department of Urology, UT Southwestern Medical Center, Dallas, TX, USA.

The prevalence of nephrolithiasis is increasing worldwide. Understanding and implementing medical therapies for kidney stone prevention are critical to prevent recurrences and decrease the economic burden of this condition. Dietary and pharmacologic therapies require understanding on the part of the patient and the prescribing practitioner in order to promote compliance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183007
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http://dx.doi.org/10.1016/j.ajur.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197179PMC
October 2018
16 Reads

Defining metabolic activity of nephrolithiasis - Appropriate evaluation and follow-up of stone formers.

Asian J Urol 2018 Oct 26;5(4):235-242. Epub 2018 Jun 26.

Universidade Federal de São Paulo, Nephrology Division, São Paulo, Brazil.

Considering the variation in metabolic evaluation and medical management of kidney stone disease, this consensus review was created to discuss the metabolic activity of nephrolithiasis, define the difference between single and recurrent stone formers, and develop a schema for metabolic and radiologic follow-up. A systematic review of the literature was performed to identify studies of metabolic evaluation and follow-up of patients with nephrolithiasis. Both single and recurrent stone formers share many similarities in metabolic profiles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183005
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http://dx.doi.org/10.1016/j.ajur.2018.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197397PMC
October 2018
11 Reads

Ureteral stents in urolithiasis.

Asian J Urol 2018 Oct 25;5(4):274-286. Epub 2018 Jul 25.

Department of Urology, University Hospital Ghent, Ghent, Belgium.

Ever since the ureteral stent design was fitted with a curl on both sides to prevent it from migrating up or down the ureter some 40 years ago, its use has gained tremendous momentum, aiding in the rise and evolution of endourology and has confidently kept its place in modern time urology. Over the past four decades, several designs, coating and biomaterials have been developed, trying to reduce infection, encrustation and other stent related symptoms. As the ideal stent has not yet been discovered, different ways of helping patients with their complaints have been researched. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197553PMC
October 2018

Stones in pregnancy and pediatrics.

Asian J Urol 2018 Oct 5;5(4):223-234. Epub 2018 Jun 5.

Division of Urology, Department of Surgery, Western University, London, Canada.

Urinary stone disease is a highly prevalent condition affecting approximately 10% of the population, and has increased in incidence significantly over the past 20 years. Along with this, the rate of stone disease among women and children is also on the rise. The management of stone disease in specific populations, such as in children and during pregnancy can present unique challenges to the urologist. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197562PMC
October 2018
20 Reads

The influence of metabolic syndrome and its components on the development of nephrolithiasis.

Asian J Urol 2018 Oct 8;5(4):215-222. Epub 2018 Jun 8.

Department of Urology, University of Alabama-Birmingham, Birmingham, AL, USA.

The prevalence of kidney stone disease is increasing, afflicting 7%-11% of the United States population. Multiple systemic conditions, including obesity and diabetes, are also on the rise. Further, the literature has demonstrated a strong association between metabolic syndrome, its components, and kidney stone disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183004
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http://dx.doi.org/10.1016/j.ajur.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197366PMC
October 2018
21 Reads

Medical and surgical management of urolithiasis.

Authors:
John D Denstedt

Asian J Urol 2018 Oct 30;5(4):203-204. Epub 2018 Aug 30.

Western University London Canada, Secretary Elect of American Urological Association, Canada.

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http://dx.doi.org/10.1016/j.ajur.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197540PMC
October 2018

Present indications and techniques of percutaneous nephrolithotomy: What the future holds?

Asian J Urol 2018 Oct 6;5(4):287-294. Epub 2018 Sep 6.

Department of Urology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel.

The purpose of the review was to present the latest updates on percutaneous nephrolithotomy (PCNL) procedure in terms of indications and evolving techniques, and to identify the advantages and disadvantages of each modality. The data for this review were collected after a thorough PubMed search in core clinical journals in English language. The key words included "PCNL" and "PNL" in combination with "indications", "techniques", "review" and "miniaturized PCNL". Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183006
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http://dx.doi.org/10.1016/j.ajur.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197369PMC
October 2018
20 Reads

Miniaturised percutaneous nephrolithotomy: Its role in the treatment of urolithiasis and our experience.

Asian J Urol 2018 Oct 14;5(4):295-302. Epub 2018 May 14.

Division of Urology, Department of Surgery, Queen Mary Hospital, Hong Kong, China.

Miniaturized percutaneous nephrolithotomy (PCNL) procedures have gained increased popularity in recent years. They aim to reduce percutaneous tract size in order to lower complication rates, while maintaining high stone-free rates. Recently, miniaturized PCNL techniques have further expanded, and can currently be classified into mini-PCNL, minimally invasive PCNL (MIP), Chinese mini-PCNL (MPCNL), ultra-mini-PCNL (UMP), micro-PCNL, mini-micro-PCNL, and super-mini-PCNL (SMP). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183003
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http://dx.doi.org/10.1016/j.ajur.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197452PMC
October 2018
11 Reads

Epidemiology of urolithiasis in Asia.

Asian J Urol 2018 Oct 6;5(4):205-214. Epub 2018 Sep 6.

Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

In Asia, about 1%-19.1% of the population suffer from urolithiasis. However, due to variations in socio-economic status and geographic locations, the prevalence and incidence have changed in different countries or regions over the years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183007
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http://dx.doi.org/10.1016/j.ajur.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197415PMC
October 2018
22 Reads

The impact of urological resection and reconstruction on patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).

Asian J Urol 2018 Jul 4;5(3):194-198. Epub 2017 Oct 4.

Division of Surgical Oncology, National Cancer Centre Singapore, Singapore.

Objective: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are increasingly being used to treat peritoneal malignancies. Urological resections and reconstruction (URR) are occasionally performed during the surgery. We aim to evaluate the impact of these procedures on peri-operative outcomes of CRS and HIPEC patients. Read More

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http://dx.doi.org/10.1016/j.ajur.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033198PMC
July 2018
6 Reads

Retroperitoneal laparoscopic non-dismembered pyeloplasty for uretero-pelvic junction obstruction due to crossing vessels: A matched-paired analysis and review of literature.

Asian J Urol 2018 Jul 6;5(3):172-181. Epub 2018 Mar 6.

Department of Urology and Pediatric Urology, SLK Kliniken Heilbronn, University of Heidelberg, Heibronn, Germany.

Objective: To compare laparoscopic Anderson-Hynes pyeloplasty (LAHP) and retroperitoneal laparoscopic YV-pyeloplasty (LRYVP) in ureteropelvic junction obstruction (UPJ) in presence of a crossing vessels (CV).

Methods: Our database showed 380 UPJO-cases,who underwent laparoscopic retroperitoneal surgery during the last 2 decades including 206 non-dismembered LRYVP, 157 dismembered pyeloplasties LAHP, and 17 cases of laparoscopic ureterolysis. Among them 198 cases were suitable for a matched-pair (2:1) analysis comparing laparoscopic retroperitoneal non-dismembered LRYVP (Group 1,  = 131) and dismembered LAHP (Group 2,  = 67) in presence of a crossing vessel. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033199PMC
July 2018
4 Reads

Outcomes of combination MRI-targeted and transperineal template biopsy in restaging low-risk prostate cancer for active surveillance.

Asian J Urol 2018 Jul 12;5(3):184-193. Epub 2017 Jul 12.

Department of Urology, Singapore General Hospital, Singapore.

Objective: Active surveillance (AS) offers a strategy to reduce overtreatment and now is a widely accepted treatment option for low-risk prostate cancer. An ideal tool for risk-stratification would detect aggressive cancers and exclude such men from taking up AS in the first place. We evaluate if a combination of transperineal template biopsy with magnetic resonance imaging (MRI)-targeted biopsy identifies significant prostate cancer amongst men initially diagnosed with low-risk prostate cancer. Read More

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http://dx.doi.org/10.1016/j.ajur.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033238PMC
July 2018
5 Reads

The choice of surgical approach in the treatment of vesico-vaginal fistulae.

Asian J Urol 2018 Jul 2;5(3):155-159. Epub 2018 Feb 2.

Academic Unit of Urology, Royal Hallamshire Hospital, Sheffield, UK.

Vesico-vaginal fistula is a global healthcare problem that has a high prevalence in sub-Saharan Africa, where obstetric complications lead to the development of this condition. Despite this, comparatively few fistula repairs are performed in well-resourced countries, where iatrogenic injury is the leading aetiological factor. As a consequence, much of our knowledge results from the experience of relatively few fistula surgeons in areas of high prevalence borne out of large case series or retrospective cohorts rather than high level evidence. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033194PMC

"Thumb's off" for acrometastasis of renal cell carcinoma: Is there a role for acrometastasectomy in the era of targeted therapy?

Asian J Urol 2018 Jul 16;5(3):199-201. Epub 2017 Oct 16.

Urology Unit, Department of General Surgery, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia.

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http://dx.doi.org/10.1016/j.ajur.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033195PMC

The aging bladder insights from animal models.

Asian J Urol 2018 Jul 26;5(3):135-140. Epub 2017 May 26.

Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Alterations in bladder function with aging are very common and are very likely to represent an increasing healthcare problem in the years to come with the general aging of the population. In this review the authors describe the prevalence of lower urinary tract symptoms (LUTS) and comment upon potential mechanisms which may be responsible for the increasing prevalence of lower LUTS with increasing age, based on laboratory studies. It is clear that there is a complex interplay between the various components of the neural innervation structure of the bladder in leading to changes with age, which are likely to underpin the LUTS which are seen in the aging bladder. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882173004
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http://dx.doi.org/10.1016/j.ajur.2017.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033201PMC
July 2018
18 Reads

Functional and reconstructive urology (part two).

Asian J Urol 2018 Jul 14;5(3):133-134. Epub 2018 May 14.

Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.

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http://dx.doi.org/10.1016/j.ajur.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033236PMC
July 2018
1 Read

Management of acquired rectourethral fistulas in adults.

Asian J Urol 2018 Jul 31;5(3):149-154. Epub 2018 Jan 31.

Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Rectourethral fistula is an uncommon but devastating condition resulting from surgery, radiation, trauma, inflammation, or occasionally anorectal anomaly. Because of involving the urinary and the digestive system, surgical repair can be challenging. More than 40 different surgical approaches were described in the literature. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032817PMC
July 2018
2 Reads

Repair of a small and crooked vesicovaginal fistula using electrocauterization.

Asian J Urol 2018 Jul 1;5(3):182-183. Epub 2018 Feb 1.

Department of Urology, Peking University People's Hospital, Beijing, China.

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http://dx.doi.org/10.1016/j.ajur.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033197PMC
July 2018
4 Reads

Treatment of posterior urethral distractions defects following pelvic fracture.

Asian J Urol 2018 Jul 27;5(3):164-171. Epub 2017 Dec 27.

Department of Urology, Universitary Hospital La Paz, Madrid, Spain.

Posterior urethral injuries typically arise in the context of a pelvic fracture. Retrograde urethrography is the preferred diagnostic test in trauma patients with pelvic fracture where a posterior urethral rupture is suspected. Pelvic fractures however preclude the adequate positioning of the patient on the X-ray table on admission and computed tomography scan with intravenous contrast and delayed films generally performed first. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882173010
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http://dx.doi.org/10.1016/j.ajur.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033243PMC
July 2018
1 Read

The treatment of complex female urethral pathology.

Asian J Urol 2018 Jul 23;5(3):160-163. Epub 2018 Mar 23.

Department of Urology, Royal Hallamshire Hospital, Sheffield, UK.

Lower urinary tract symptoms (LUTS) in women produce significant bother. Common conditions causing LUTS in women include urinary tract infections, overactive bladder, and stress incontinence. Urethral diverticulae and female urethral strictures are rare pathologies. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032816PMC
July 2018
2 Reads

Contemporary diagnostics and treatment options for female stress urinary incontinence.

Asian J Urol 2018 Jul 14;5(3):141-148. Epub 2017 Sep 14.

Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.

Stress urinary incontinence is not a deadly disease, but for the large population of women suffering from it, it is a very important issue. Especially in the continuously aging population all over the world, there is more and more need for treatment of this serious medical condition. Treatment of female stress urinary incontinence exists already for ages. Read More

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http://dx.doi.org/10.1016/j.ajur.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033196PMC
July 2018
7 Reads

A rare case of isolated castrate resistant bilateral testicular metastases in advanced prostate cancer.

Asian J Urol 2018 Apr 8;5(2):127-130. Epub 2017 Mar 8.

Department of Urology, Singapore General Hospital, Singapore.

Testicular metastasis is rare with the prostate being the most common site of primary cancer. We report a case of a 72-year-old man with castration-resistant prostate cancer (CRPC) and known metastases to bone and lymph nodes, who developed bilateral painful swollen testes 3 years after the initial diagnosis of prostate cancer. He had first presented with lower urinary tract symptoms (LUTS) with suspicious findings on digital rectal examination of the prostate, and an elevated serum prostate specific antigen (PSA) level of 129 ng/mL. Read More

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http://dx.doi.org/10.1016/j.ajur.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934351PMC
April 2018
25 Reads

The effect of adjunct caudal block on postoperative analgesia in robot-assisted laparoscopic radical prostatectomy: A prospective randomized controlled, single blinded pilot study in a tertiary centre.

Asian J Urol 2018 Apr 24;5(2):122-126. Epub 2017 Jun 24.

Department of Anaesthesiology, Singapore General Hospital, Singapore.

Objective: Caudal block provides satisfactory postoperative pain relief in lower abdominal operations. This pilot study explores its safety and effect on postoperative pain control in patients who underwent robot-assisted laparoscopic radical prostatectomy (RARP).

Methods: From 2013 to 2014, 40 consecutive patients were randomized into two groups - one received caudal block using ropivacaine immediately after operation, the other received standard analgesia. Read More

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http://dx.doi.org/10.1016/j.ajur.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934515PMC
April 2018
1 Read

The association of benign prostatic hyperplasia with lower urinary tract stones in adult men: A retrospective multicenter study.

Asian J Urol 2018 Apr 20;5(2):118-121. Epub 2017 Jun 20.

Department of Urology, Konkuk University, School of Medicine, Chungju, Korea.

Objective: To examine the relationship between benign prostatic hyperplasia (BPH) and the presence of lower urinary tract stones.

Methods: We retrospectively reviewed the records of men with lower urinary tract stones who presented to three clinical centers in Korea over a 4-year period. We divided the patients into two groups based on the location of urinary stones: Group 1 (bladder calculi) and Group 2 (urethral calculi). Read More

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http://dx.doi.org/10.1016/j.ajur.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934505PMC
April 2018
9 Reads

Management of complex and redo cases of pelvic fracture urethral injuries.

Asian J Urol 2018 Apr 2;5(2):107-117. Epub 2018 Mar 2.

Department of Reconstructive Urology, Kulkarni Reconstructive Urology Centre, Pune, India.

Objectives: Pelvic fracture urethral injuries (PFUI) result from traumatic disruption of the urethra. A significant proportion of cases are complex rendering their management challenging. We described management strategies for eight different complex PFUI scenarios. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934510PMC
April 2018
3 Reads

Adult iatrogenic ureteral injury and stricture-incidence and treatment strategies.

Asian J Urol 2018 Apr 17;5(2):101-106. Epub 2018 Feb 17.

Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Iatrogenic ureteral injuries and strictures are relatively common complication of pelvic surgery and radiation treatment. Left untreated they are associated with severe short- and long-term complications such as urinoma, septic state, renal failure, and loss of a renal unit. Treatment depends on timing of diagnosis, as well as extent of injury, and ranges from simple endoscopic management to complex surgical reconstruction under usage of pedicled grafts. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934506PMC
April 2018
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Prevention strategies for ureteral stricture following ureteroscopic lithotripsy.

Asian J Urol 2018 Apr 22;5(2):94-100. Epub 2017 Sep 22.

Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Ureteral stricture formation after ureteroscopic lithotripsy is a late complication that can lead to hydronephrosis and a subsequent risk of renal deterioration. The specific incidence is unknown, and the mechanism of stricture formation has not been completely explained. In this review, we summarize the current evidence regarding the incidence of this condition and discuss its pathogenesis. Read More

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http://dx.doi.org/10.1016/j.ajur.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934507PMC
April 2018
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A brief review on anterior urethral strictures.

Asian J Urol 2018 Apr 31;5(2):88-93. Epub 2017 Dec 31.

Department of Urology, Peking University First Hospital, Beijing, China.

The treatment of urethral strictures remains a challenging field in urology even though there are a variety of procedures to treat it at present, as no one approach is superior over another. This paper reviewed the surgical options for the management of different sites and types of anterior urethral stricture, providing a brief discussion of the controversies regarding this issue and suggesting possible future advancements. Among the existing procedures, simple dilation and direct vision internal urethrotomy are more commonly used for short urethral strictures ( <1 cm, soft and no previous intervention). Read More

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http://dx.doi.org/10.1016/j.ajur.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934508PMC
April 2018
2 Reads

Emergency treatment of male blunt urethral trauma in China: Outcome of different methods in comparison with other countries.

Asian J Urol 2018 Apr 7;5(2):78-87. Epub 2017 Aug 7.

Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Treatment of male urethral trauma is always a challenging problem. In China, as the incidence of urethral trauma keeps rising, more and more studies relating to this are being published. To compare the outcome of different emergency treatments in China and other countries, we searched Chinese and English literature about this topic in the past 16 years. Read More

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http://dx.doi.org/10.1016/j.ajur.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934509PMC
April 2018
2 Reads

Overcoming scarring in the urethra: Challenges for tissue engineering.

Asian J Urol 2018 Apr 12;5(2):69-77. Epub 2018 Feb 12.

Department of Materials Science & Engineering, Kroto Research Institute, University of Sheffield, Sheffield, UK.

Urethral stricture disease is increasingly common occurring in about 1% of males over the age of 55. The stricture tissue is rich in myofibroblasts and multi-nucleated giant cells which are thought to be related to stricture formation and collagen synthesis. An increase in collagen is associated with the loss of the normal vasculature of the normal urethra. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934514PMC
April 2018
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Tissue engineering for urinary tract reconstruction and repair: Progress and prospect in China.

Asian J Urol 2018 Apr 23;5(2):57-68. Epub 2017 Jun 23.

Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Several urinary tract pathologic conditions, such as strictures, cancer, and obliterations, require reconstructive plastic surgery. Reconstruction of the urinary tract is an intractable task for urologists due to insufficient autologous tissue. Limitations of autologous tissue application prompted urologists to investigate ideal substitutes. Read More

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http://dx.doi.org/10.1016/j.ajur.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934513PMC
April 2018
4 Reads

Functional and reconstructive urology (part one).

Asian J Urol 2018 Apr 17;5(2):55-56. Epub 2018 Feb 17.

Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, PR China.

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http://dx.doi.org/10.1016/j.ajur.2018.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934511PMC
April 2018
1 Read

Successful removal of a penoscrotal constricting ring in a 49-year-old male.

Asian J Urol 2017 Oct 6;4(4):262-264. Epub 2017 Mar 6.

Department of Urology, Singapore General Hospital, Singapore.

Placement of constricting devices around the penis and scrotum for autoerotic purposes or increasing sexual performance represents a well-known challenge for urologists and can result in serious complications. The removal of the constricting devices can be challenging and often requires resourcefulness and multidisciplinary approach. We report one case of successful removal of a penoscrotal constricting metal ring in a 49-year-old male using a hand-held orthopaedic saw under ketamine and midazolam sedation in the emergency department. Read More

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http://dx.doi.org/10.1016/j.ajur.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773043PMC
October 2017
2 Reads

Inadvertent placement of a urinary catheter into the ureter: A report of 3 cases and review of the literature.

Asian J Urol 2017 Oct 4;4(4):256-261. Epub 2016 Sep 4.

Department of Urology, Changi General Hospital, Singapore.

We describe three cases of inadvertent placement of the urinary catheter into the ureter. An 85-year-old gentleman on long-term indwelling catheter (IDC) for neurogenic bladder presented with fever and right flank pain. CT of abdomen and pelvis demonstrated the tip of the IDC to be located within the right vesicoureteric junction with acute right hydronephrosis and acute pyelonephritis. Read More

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http://dx.doi.org/10.1016/j.ajur.2016.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773021PMC
October 2017
2 Reads