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    1482 results match your criteria Asian Pacific journal of tropical medicine[Journal]

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    An atypical case of disseminated cutaneous leishmaniasis due to Leishmania peruviana in the valleys of Ancash-Peru.
    Asian Pac J Trop Med 2017 Nov 7;10(11):1101-1103. Epub 2017 Nov 7.
    School of Medicine, Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cdra 2 Cedros de Villa, Lima, Peru; Research Center and Innovation of the Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cdra 2 Chorrillos, Lima, Peru. Electronic address:
    We present an atypical case of disseminated cutaneous leishmaniasis in the Sihuas district, located in the Andean valleys of Ancash-Peru. A 62-year-old man with no particular medical history presented multiple lesions located on the inferior abdomen, lumbar region and the right anterior thigh. Histological analysis found leishmanial amastigotes in the lesion sample, the Montenegro reaction was positive for Leishmania spp, and the polymerase chain reaction was positive for Leishmania peruviana. Read More

    Influence of light intensity and water content of medium on total dendrobine of Dendrobium nobile Lindl.
    Asian Pac J Trop Med 2017 Nov 28;10(11):1095-1100. Epub 2017 Oct 28.
    Guizhou University, Guiyang, Guizhou 550025, China; Guizhou Key (Engineering) Laboratory for Propagation and Cultivation of Medicinal Plants, Guiyang 550025, China.
    Objective: To ascertain the influence of light intensity and water content of medium on the total dendrobine of Dendrobium nobile (D. nobile).

    Method: The principal component analysis combined with total dendrobine accumulation was conducted to assess the yield and quality of D. Read More

    Effect of taurine on immune function in mice with T-cell lymphoma during chemotherapy.
    Asian Pac J Trop Med 2017 Nov 28;10(11):1090-1094. Epub 2017 Oct 28.
    Department of Hematology and Rheumatology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350000, China.
    Objective: To observe the effect of taurine on immune function in mice with T-cell lymphoma during chemotherapy.

    Methods: A total of 40 C57BL/6 mice were selected and randomly divided into 4 groups, namely model group, chemotherapy group, taurine group and chemotherapy + taurine group, each containing 10 mice. Hypodermic injection was adopted to inoculate EL-4 cells in order to establish model of T-cell lymphoma. Read More

    Glypican-3-specific cytotoxic T lymphocytes induced by human leucocyte antigen-A*0201-restricted peptide effectively kill hepatocellular carcinoma cells in vitro.
    Asian Pac J Trop Med 2017 Nov 28;10(11):1084-1089. Epub 2017 Oct 28.
    Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510310, China. Electronic address:
    Objective: To investigate potential human leucocyte antigen (HLA)-A2-restricted epitope peptides of glypican-3 (GPC3) and determine the cytotoxicity of peptide-specific cytotoxic T lymphocytes (CTLs) against hepatocellular carcinoma (HCC) cells.

    Methods: The potential HLA-A*0201-restricted GPC3 peptides were screened using computer algorithms, T2 cell-binding affinity and stability of peptide/HLA-A*0201 complex assay. The peptide-specific CTLs were generated and their cytotoxicity against GPC3+ SMMC 7721 and HepG2 cells was detected using IFN-γ based enzyme-linked immunospot and lactate dehydrogenase release assays in vitro. Read More

    Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions.
    Asian Pac J Trop Med 2017 Nov 28;10(11):1080-1083. Epub 2017 Oct 28.
    Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Paraná, Brazil.
    Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus (PDA) in premature neonates with significant clinical and hemodynamic repercussions (CHRs) and to determine the effect of these respective treatments on renal function.

    Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin [0. Read More

    Bartonella infection in asymptomatic horses and donkeys from Tuscany, Central Italy.
    Asian Pac J Trop Med 2017 Nov 28;10(11):1077-1079. Epub 2017 Oct 28.
    Department of Veterinary Science, University of Pisa, Viale Delle Piagge 2, 56124 Pisa, Italy. Electronic address:
    Objective: To investigate the occurrence of Bartonella sp. infection in asymptomatic horses and donkeys living in Tuscany, Central Italy.

    Methods: Blood samples were collected from 77 horses and 15 donkeys and tested by indirect immunofluorescent test to detect antibodies against Bartonella sp. Read More

    Evaluating the effect of Myrtus communis on programmed cell death in hydatid cyst protoscolices.
    Asian Pac J Trop Med 2017 Nov 28;10(11):1072-1076. Epub 2017 Oct 28.
    Department of Social Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
    Objective: To evaluate the possible involvement of programmed cell death strategy in hydatid cyst protoscolices following treatment with Myrtus communis (M. communis) as an herbal medicine.

    Methods: Protoscolices were aseptically collected from sheep liver hydatid cysts. Read More

    Association of TNFA (-308G/A), IFNG (+874 A/T) and IL-10 (-819 C/T) polymorphisms with protection and susceptibility to dengue in Brazilian population.
    Asian Pac J Trop Med 2017 Nov 28;10(11):1065-1071. Epub 2017 Oct 28.
    Molecular Biology and Gene Expression Laboratory, Federal University of Alagoas, Campus Arapiraca, Av Manoel Severino Barbosa, Bom Sucesso, Arapiraca, AL, 57309-005, Brazil. Electronic address:
    Objective: To evaluate gene polymorphisms and their association with susceptibility to dengue.

    Methods: A retrospective case-control study was performed with 262 subjects, comprising 78 dengue fever (DF) patients, 49 dengue hemorrhagic fever (DHF) patients and 135 healthy controls. Genotypic and allelic profiles were identified using polymerase chain reaction based in real time and amplification-refractory mutation system. Read More

    Antimicrobial resistance and underlying mechanisms in Staphylococcus aureus isolates.
    Asian Pac J Trop Med 2017 Nov 8;10(11):1059-1064. Epub 2017 Nov 8.
    Department of Microbiology, Faculty of Veterinary Medicine, Mustafa Kemal University, Antakya-Hatay, 31040, Turkey.
    Objective: To investigate the antimicrobial susceptibility of 97 clinical Staphylococcus aureus (S. aureus) strains against 14 antimicrobials and corresponding resistance mechanisms.

    Methods: The antimicrobial susceptibility of the isolates was determined using a disk diffusion method and antimicrobial resistance genes were screened by polymerase chain reaction. Read More

    Efficient hepatoprotective activity of cranberry extract against CCl4-induced hepatotoxicity in Wistar albino rat model: Down-regulation of liver enzymes and strong antioxidant activity.
    Asian Pac J Trop Med 2017 Nov 27;10(11):1054-1058. Epub 2017 Oct 27.
    Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300, Selangor, Malaysia. Electronic address:
    Objective: To investigate the hepatoprotective efficacy of cranberry extract (CBE) against carbon tetrachloride (CCl4)-induced hepatic injury using in-vivo animal model.

    Methods: The hepatoprotective efficacy of CBE (200 and 400 mg/kg) was investigated against CCl4 (4 mL/kg)-induced hepatotoxicity, elevated liver enzymes [ALT (alanine aminotransferase), AST (aspartate aminotransferase), and alkaline phosphatase (ALP)], and total protein (TP) contents in the serum. Moreover, CBE-aided antioxidant defense against hepatotoxic insult of CCl4 was measured by evaluating a number of anti-oxidative biomarkers including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in the serum by using spectrophotometric analyses. Read More

    Antioxidant, anti-inflammatory and antinociceptive potential of Ternstroemia sylvatica Schltdl. & Cham.
    Asian Pac J Trop Med 2017 Nov 27;10(11):1047-1053. Epub 2017 Oct 27.
    Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Xalapa, Veracruz, Mexico. Electronic address:
    Objective: To evaluate the anti-inflammatory, analgesic, antioxidant and acute toxicity of extracts obtained from a successive extraction with solvents of ascending polarity [hexane, hex; chloroform, CHCl3 and ethanol (EtOH)] of Ternstroemia sylvatica Schltdl. & Cham.

    Methods: The antioxidant potential was evaluated by 2,2 diphenyl-1-picrylhydrazyl, the ferric reducing/antioxidant power assays and by determining the total phenolic content. Read More

    Effects of 8-Hydroxyisocapnolactone-2-3-diol and friedelin on mast cell degranulation.
    Asian Pac J Trop Med 2017 Nov 31;10(11):1043-1046. Epub 2017 Oct 31.
    Department of Pharmacology, Graduate School of Medicine, Ehime University, Ehime, 791-0295, Japan.
    Objective: To investigate the effects of friedelin (terpenoid) and 8-hydroxyisocapnolactone-2-3-diol (coumarin) with concentration 10 μM, 30 μM, and 100 μM on inhibiting mast cells (MCs) degranulation.

    Methods: The investigation was performed in vitro by administering each compound into rat peritoneal MCs and rat basophilic leukemia-2H3 cells followed by activation with 50 μg/mL of compound 48/80 or 1 μM of ionomycin. The concentration of histamine released from each group was measured by a high-performance liquid chromatography-fluorometry system with post-column derivatization using o-phthalaldehyde. Read More

    Pattern of hepatitis C virus genotypes and subtypes circulating in war-stricken Khyber Pakhtunkhwa, Pakistan: Review of published literature.
    Asian Pac J Trop Med 2017 Nov 7;10(11):1037-1042. Epub 2017 Nov 7.
    Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan.
    Infection due to hepatitis C virus (HCV) is a major cause of fibrosis and hepatocellular carcinoma in Pakistan. In the current review, pattern of HCV genotypes and subtypes in Khyber Pakhtunkhwa province was ascertained in light of the available literature. After thorough analysis, genotype 3 (58. Read More

    Euclea undulata Thunb.: Review of its botany, ethnomedicinal uses, phytochemistry and biological activities.
    Asian Pac J Trop Med 2017 Nov 27;10(11):1030-1036. Epub 2017 Oct 27.
    Medicinal Plants and Economic Development (MPED) Research Centre, Department of Botany, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa. Electronic address:
    Euclea undulata (E. undulata) is traditionally used for the treatment of body pains, chest complaints, cough, diabetes, diarrhoea, headaches, heart diseases and toothaches in southern Africa. This study was aimed at reviewing the botany, ethnopharmacology and biological activities of E. Read More

    Meningococcal disease, a clinical and epidemiological review.
    Asian Pac J Trop Med 2017 Nov 28;10(11):1019-1029. Epub 2017 Oct 28.
    School of Medicine, New York University - NYU, New York, USA; Departamento de Genética Médica, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
    Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. Read More

    Molecular and serological prevalence of Toxoplasma gondii in pregnant women and sheep in Egypt.
    Asian Pac J Trop Med 2017 Oct 19;10(10):996-1001. Epub 2017 Sep 19.
    Department of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt; Clinical Pathology Unit, National Liver Institute, Menoufia University, Egypt.
    Objective: To investigate molecular and serological prevalence of Toxoplasma gondii (T. gondii) in pregnant women and sheep in Egypt.

    Methods: Blood samples collected from healthy 364 pregnant women and 170 sheep were investigated for T. Read More

    Giardia duodenalis infection among rural communities in Yemen: A community-based assessment of the prevalence and associated risk factors.
    Asian Pac J Trop Med 2017 Oct 18;10(10):987-995. Epub 2017 Sep 18.
    Endemic and Tropical Diseases Unit, Medical Research Center, Jazan University, Jazan, Saudi Arabia; Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. Electronic address:
    Objective: To investigate the prevalence and risk factors of Giardia infection among rural communities among rural communities in Yemen.

    Methods: In this cross-sectional study, a total of 605 stool samples were collected and screened for the presence of Giardia duodenalis (G. duodenalis) cysts and/or trophozoites by using three different diagnostic methods: direct smear, formalin-ether sedimentation, and trichrome staining. Read More

    Synergists action of piperonyl butoxide and S,S,S-tributyl phosphorotrithioate on toxicity of carbamate insecticides against Blattella germanica.
    Asian Pac J Trop Med 2017 Oct 18;10(10):981-986. Epub 2017 Sep 18.
    Department of Parasitology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:
    Objective: To determine the synergists action of piperonyl butoxide (PBO) and S,S,S-tributyl phosphorotrithioate (DEF) on toxicity of carbamate insecticides against Blattella germanica in Tehran city.

    Methods: In the current study, German cockroach strains were collected from several hospitals and dormitories in Tehran. At the beginning, different concentrations of bendiocarb and carbaryl (insecticides belong to carbamate group) were determined by surface contact on a susceptible strain. Read More

    Antioxidant and diuretic activity of co-administration of Capparis spinosa honey and propolis in comparison to furosemide.
    Asian Pac J Trop Med 2017 Oct 18;10(10):974-980. Epub 2017 Sep 18.
    Laboratory Physiology-Pharmacology & Environmental Health, Faculty of Sciences Dhar-Mahraz, University Sidi Mohamed Ben Abdallah, Fez, Morocco.
    Objective: To study the antioxidant properties of Capparis spinosa (C. spinosa) honey and propolis and the effect of combined honey and propolis administration on urine volume and electrolytes in rats.

    Methods: C. Read More

    Antifungal, molluscicidal and larvicidal assessment of anemonin and Clematis flammula L. extracts against mollusc Galba truncatula, intermediate host of Fasciola hepatica in Tunisia.
    Asian Pac J Trop Med 2017 Oct 20;10(10):967-973. Epub 2017 Sep 20.
    Laboratory of Organic Chemistry LR17ES08 (Natural Substances Team), University of Sfax, Faculty of Sciences, 3000 Sfax, Tunisia.
    Objective: To investigate the potential of anemonin and Clematis flammula (C. flammula) extracts against infective organisms.

    Methods: The molluscicidal activities of anemonin and C. Read More

    Protective potency of Meristotropis xanthioides against nephrotoxicity in a rat model along with its antioxidant and antibacterial activities.
    Asian Pac J Trop Med 2017 Oct 18;10(10):960-966. Epub 2017 Sep 18.
    Department of Biology, Faculty of Science, Bu-Ali Sina University, P. O. Box 65175/4161, Hamedan, Iran.
    Objective: To investigate nephroprotective potential of Meristotropis xanthioides (M. xanthioides) extract against ethanol-induced nephrotoxicity in Wistar rats, and also its total phenolics content, antioxidant and antibacterial activities.

    Methods: Total phenol and flavonoid amounts of the leaf and stem extracts were determined by Folin-Ciocalteu and aluminum chloride reagents, respectively. Read More

    Chemical composition, antioxidant and antibacterial activities of essential oil and methanol extract of Artemisia vulgaris and Gaultheria fragrantissima collected from Nepal.
    Asian Pac J Trop Med 2017 Oct 18;10(10):952-959. Epub 2017 Sep 18.
    Department of Biotechnology, Kathmandu University, Dhulikhel, Kavre, Nepal.
    Objective: To identify the chemical constituents and biological activities of essential oil and crude methanol extract of Artemisia vulgaris (A. vulgaris) and Gaultheria fragrantissima (G. fragrantissima). Read More

    Clinical and environmental isolates of Burkholderia pseudomallei from Brazil: Genotyping and detection of virulence gene.
    Asian Pac J Trop Med 2017 Oct 18;10(10):945-951. Epub 2017 Sep 18.
    Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
    Objective: To evaluate the genetic diversity of clinical and environmental isolates of Burkholderia pseudomallei (B. pseudomallei) recovered in Ceará, Brazil, and screen these isolates for the presence of type three secretion system virulence gene.

    Methods: Nineteen B. Read More

    Food intake regulation by leptin: Mechanisms mediating gluconeogenesis and energy expenditure.
    Asian Pac J Trop Med 2017 Oct 18;10(10):940-944. Epub 2017 Sep 18.
    Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, 38040, Pakistan. Electronic address:
    Regulation of blood glucose levels and body fat is critical for survival. Leptin circulates freely in blood and controls body weight and food intake mainly through hypothalamic receptors and regulates glucose metabolism in the liver both directly through leptin receptors and indirectly via the hypothalamic receptors of central nervous system. Leptin affects food intake regulation and eventually glucose metabolism, lipometabolism, endocrine and immune functions, reproductive function, adipose tissue metabolism and energy expenditure. Read More

    A review of five traditionally used anti-diabetic plants of Bangladesh and their pharmacological activities.
    Asian Pac J Trop Med 2017 Oct 18;10(10):933-939. Epub 2017 Sep 18.
    Department of Pharmacy, Southeast University, Dhaka, Bangladesh. Electronic address:
    Plants are used traditionally throughout the globe to treat various diseases. Traditionally used medicinal plants are an essential part of the health sector in Bangladesh due to its abundance of a vast source of ethno-medicine. Rural people from developing country like Bangladesh are greatly dependent on traditional source of medicine. Read More

    Plasmodium falciparum found in the bone marrow of a child in Manado City, East Indonesia: A case report.
    Asian Pac J Trop Med 2017 Oct 23;10(10):1015-1017. Epub 2017 Sep 23.
    Department of Pediatric, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia. Electronic address:
    In Indonesia, there are at least 1.3 million cases of malaria each year and Plasmodium falciparum appears to be the most common Plasmodium. The finding of Plasmodium is important for the diagnosis and management of malaria. Read More

    Morphological characteristics associated with rupture risk of multiple intracranial aneurysms.
    Asian Pac J Trop Med 2017 Oct 19;10(10):1011-1014. Epub 2017 Sep 19.
    Department of Radiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Electronic address:
    Objective: To identify the morphological parameters that are related to intracranial aneurysms (IAs) rupture using a case-control model.

    Methods: A total of 107 patients with multiple IAs and aneurysmal subarachnoid hemorrhage between August 2011 and February 2017 were enrolled in this study. Characteristics of IAs location, shape, neck width, perpendicular height, depth, maximum size, flow angle, parent vessel diameter (PVD), aspect ratio (AR) and size ratio (SR) were evaluated using CT angiography. Read More

    Neuron-protective effect of subanesthestic-dosage ketamine on mice of Parkinson's disease.
    Asian Pac J Trop Med 2017 Oct 18;10(10):1007-1010. Epub 2017 Sep 18.
    Department of Anesthesiology, First Affiliated Hospital of Henan University, Kaifeng, Henan, 475000, China.
    Objective: To discuss the neuron-protective effect and possible mechanism of subanesthestic-dosage ketamine on Parkinson's disease mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

    Methods: A total of 30 mice were divided equally into three groups, model control group (MC group), ketamine treatment group (KT group), and blank control group (BC group), respectively. The Parkinson's disease mice of MC group and KT groups were established by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (20 mg/kg/d), while mice in KT group were treated by intraperitoneal injection of subanesthestic-dosage ketamine (8 mg/kg). Read More

    Asymptomatic dengue infection in adults of major cities of Pakistan.
    Asian Pac J Trop Med 2017 Oct 19;10(10):1002-1006. Epub 2017 Sep 19.
    Pakistan Health Research Council, Head Office, Islamabad, Pakistan.
    Objective: To determine the asymptomatic dengue infection in adults of Pakistani population.

    Methods: This study was conducted in five major cities (Islamabad, Karachi, Lahore, Multan, and Peshawar) of Pakistan. A total of 5 230 adults aged 18 years and above without a history of dengue fever at any point in their life were enrolled from participating laboratories. Read More

    Diversity of livestock associated methicillin-resistant Staphylococcus aureus.
    Asian Pac J Trop Med 2017 Sep 13;10(9):929-931. Epub 2017 Sep 13.
    Department of Bacteriology, Veterinary Research Institute, Brno, Czech Republic.
    Objective: To evaluate the diversity and molecular characteristics of livestock associated methicillin-resistant Staphylococcus aureus in livestock animals, food of animal origin and the environment in the Czech Republic.

    Methods: After having been primarily enriched in buffered peptone water, the samples were cultured on Baird-Parker agar. Presumptive colonies were sub-cultured to blood agar and assessed morphologically. Read More

    Introduction of Zika virus in Bangladesh: An impending public health threat.
    Asian Pac J Trop Med 2017 Sep 13;10(9):925-928. Epub 2017 Sep 13.
    Institute of Epidemiology, Disease Control & Research (IEDCR), Dhaka, Bangladesh.
    Objective: To explore the presence of Zika virus (ZIKV) in Bangladesh and to understand the associated risk factors.

    Methods: A retrospective sero-surveillance was performed on stored serum samples of dengue surveillance conducted from 2013 to 2016. Real time RT-PCR was performed on randomly selected acute serum samples to detect the Zika virus nucleic acid. Read More

    Relationship between abnormal vagus nerve tension and basal ganglia cerebral infarction induced paroxysmal atrial fibrillation.
    Asian Pac J Trop Med 2017 Sep 14;10(9):921-924. Epub 2017 Sep 14.
    Department of Geriatrics, Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus, Shanghai 201400, China. Electronic address:
    Objective: To investigate the relationship between basal ganglia cerebral infarction and paroxysmal atrial fibrillation (PAF) caused by abnormal vagus nerve tension.

    Methods: A total of 1483 cases of elder patients with cerebral infarction who received head CT or MRI examination during the period were enrolled, including 830 male and 613 female, with the average age as 78 years. These cases were divided into basal infarction ganglia group (n = 1045) and non-basal ganglia infarction group (n = 438) according to the anatomic site of cerebral infarction. Read More

    Elevated serum prostaglandin E2 predicts the risk of infection in hepatitis B virus-related acute-on-chronic liver failure patients.
    Asian Pac J Trop Med 2017 Sep 7;10(9):916-920. Epub 2017 Oct 7.
    Department of Infectious Diseases, The First Affiliated Hospital of Suzhou University, Suzhou, China. Electronic address:
    Objective: To evaluate the serum Prostaglandin E2 (PGE2) level in Acute-on-chronic liver failure (ACLF) and determine its predicative value for infection.

    Methods: From April 2014 to April 2015, ninety-one patients with hepatitis B virus and ACLF but without infection were enrolled into this prospective study that was carried out at our Hospital. Twenty patients with stable chronic hepatitis B were enrolled from the outpatient department and twenty healthy control subjects without any disease were enrolled from hospital staff. Read More

    Biomass accumulation of Panax vietnamensis in cell suspension cultures varies with addition of plant growth regulators and organic additives.
    Asian Pac J Trop Med 2017 Sep 15;10(9):907-915. Epub 2017 Sep 15.
    Genetic Engineering Department, Institute of Tropical Biology, Vietnam Academy of Science and Technology, 9/621 Ha Noi Highway, Linh Trung, Thu Duc, Ho Chi Minh City, Viet Nam.
    Objective: To evaluate the impact of plant growth regulators including kinetin (KN), benzyl adenine and naphthalene acetic acid, yeast extract and casein hydrolyzate on biomass accumulation of Vietnamese ginseng Panax vietnamensis (P. vietnamensis) in cell suspension culture.

    Methods: Cell suspension cultures were established from friable calluses derived from leaves and petioles of 3-year-old in-vitro P. Read More

    Comparison of hypotensive, diuretic and renal effects between cladodes of Opuntia ficus-indica and furosemide.
    Asian Pac J Trop Med 2017 Sep 13;10(9):900-906. Epub 2017 Sep 13.
    Physiology-Pharmacology and Environmental Health Laboratory, Faculty of Sciences Dhar Mahraz, University Sidi Mohamed Ben Abdellah, Fez, Morocco.
    Objective: To investigate the diuretic, hypotensive and renal effect of Opuntia ficus-indica in two different species in oral and intravenous administration.

    Methods: Diuretic activity was evaluated in rats with the plant cladode gel and aqueous extract administrated orally, and was evaluated in rabbits with plant extract administered intravenously. Single and repeated doses of cladode gel or aqueous extract of cladode were tested. Read More

    Astrodaucus persicus as a new source of bioinsectisides against malaria vector, Anopheles stephensi.
    Asian Pac J Trop Med 2017 Sep 13;10(9):896-899. Epub 2017 Sep 13.
    Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
    Objective: To determine the larvicidal activities of petroleum ether, chloroform, ethyl acetate and methanol fractions of roots and fruits extracts of Astrodaucus persicus from Apiaceae family against malaria vector, Anopheles stephensi (An. stephensi).

    Methods: Twenty five third instar larvae of An. Read More

    Antimicrobial activity of water and acetone extracts of some Eucomis taxa.
    Asian Pac J Trop Med 2017 Sep 14;10(9):892-895. Epub 2017 Sep 14.
    Center of Bioimmobilisation and Innovative Packaging Materials, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology Szczecin, Janickiego 35, 71-270 Szczecin, Poland.
    Objective: To evaluate the antibacterial and antifungal properties of acetone and water extracts of selected Eucomis taxa.

    Methods: The bulbs of Eucomis bicolor, Eucomis comosa (E. comosa) and E. Read More

    Wash resistance and bio-efficacy of Olyset® Plus, a long-lasting insecticide-treated mosquito net with synergist against malaria vector, Anopheles stephensi.
    Asian Pac J Trop Med 2017 Sep 14;10(9):887-891. Epub 2017 Sep 14.
    Department of Medical Entomology & Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Objective: To determine the wash resistance of Olyset® Plus using World Health Organization Pesticide Evaluation Scheme standard washing procedure and to assess the value of knock down and mortality rates of Anopheles stephensi at different regimens of long lasting insecticide treated nets washings.

    Methods: The study was conducted at the Bioassay Laboratory of Culicidae Insectary, School of Public Health, Tehran University of Medical Sciences, Iran. The net was made of polyester impregnated with permethrin and piperonyl butoxide at a ratio of 2:1. Read More

    A new approach for development of vaccine against visceral leishmaniasis: Lipophosphoglycan and polyacrylic acid conjugates.
    Asian Pac J Trop Med 2017 Sep 15;10(9):877-886. Epub 2017 Sep 15.
    Yildiz Technical University, Department of Bioengineering, Istanbul, Turkey.
    Objective: To determine the antileishmanial vaccine effectiveness of lipophosphoglycan (LPG) and polyacrylic acids (PAA) conjugates on in vivo mice models.

    Methods: LPG molecule was isolated and purified from large-scale Leishmania donovani parasite culture. Protection efficacies of LPG alone, in combination with Freund's adjuvant, in a physical mixture and in conjugate (consisting of various LPG concentrations) with PAA, were comparatively determined by various techniques, such as cultivation with the micro-culture method, assessment of in vitro infection rates of peritoneal macrophages, determination of parasite load in liver with Leishman-Donovan Units, and detection of cytokine responses. Read More

    Antiviral activity of five Asian medicinal pant crude extracts against highly pathogenic H5N1 avian influenza virus.
    Asian Pac J Trop Med 2017 Sep 14;10(9):871-876. Epub 2017 Sep 14.
    Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand. Electronic address:
    Objective: To study the antiviral properties of the five Asian medicinal plants against in vitro infection by the highly pathogenic avian influenza virus (H5N1).

    Methods: Crude extracts of Andrographis paniculata, Curcuma longa (C. longa), Gynostemma pentaphyllum, Kaempferia parviflora (K. Read More

    Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis.
    Asian Pac J Trop Med 2017 Sep 13;10(9):864-870. Epub 2017 Sep 13.
    Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan, Republic of Korea. Electronic address:
    Objective: To investigate the anti-inflammatory effects of decursin and decursinol angelate-rich Angelica gigas Nakai (AGNE) on dextran sulfate sodium (DSS)-induced murine ulcerative colitis (UC).

    Methods: The therapeutic effect of an AGNE was analyzed in a mouse model of UC induced by DSS. Disease activity index values were measured by clinical signs such as a weight loss, stool consistency, rectal bleeding and colon length. Read More

    Phylogeography, genetic variability and structure of Acanthamoeba metapopulations in Iran inferred by 18S ribosomal RNA sequences: A systematic review and meta-analysis.
    Asian Pac J Trop Med 2017 Sep 14;10(9):855-863. Epub 2017 Sep 14.
    Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
    Objective: To verify phylogeography and genetic structure of Acanthamoeba populations among the Iranian clinical isolates and natural/artificial environments distributed in various regions of the country.

    Methods: We searched electronic databases including Medline, PubMed, Science Direct, Scopus and Google Scholar from 2005 to 2016. To explore the genetic variability of Acanthamoeba sp, 205 sequences were retrieved from keratitis patients, immunosuppressed cases and environmental sources as of various geographies of Iran. Read More

    An overview on cardioprotective and anti-diabetic effects of thymoquinone.
    Asian Pac J Trop Med 2017 Sep 9;10(9):849-854. Epub 2017 Oct 9.
    Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, 14139-93186, Iran.
    Thymoquinone (TQ), one of the active components of Nigella sativa exhibited to have many biological effects. Several beneficial effects of TQ such as its antidiabetic, antioxidant, anticancer, hypolipidemic, and anti-inflammatory activities have been recognized. The present review focuses on the findings of recent studies on the protective effects of TQ against cardiovascular diseases. Read More

    Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects.
    Asian Pac J Trop Med 2017 Sep 13;10(9):835-848. Epub 2017 Sep 13.
    Department of Molecular Biology and Biotechnology, Pan African University Institute for Basic Sciences, Technology and Innovation (PAUSTI), P.O. Box, 62000-00200 Nairobi, Kenya; Department of Biochemistry, Faculty of Agriculture, Cairo University, 12613 Giza, Egypt.
    Annona muricata (A. muricata) is a tropical plant species belonging to family Annonaceae and known for its many medicinal uses. This review focuses on the research history of its traditional uses, phytochemicals, pharmacological activities, toxicological aspects of the extracts and isolated compounds, as well as the in vitro propagation studies with the objective of stimulating further studies on this plant for human consumption and treatment. Read More

    Brucellosis: A lymphoma-like presentation.
    Asian Pac J Trop Med 2017 Aug 21;10(8):833-834. Epub 2017 Aug 21.
    Holy Spirit University of Kaslik, Medical School, Lebanon; CHU-Notre Dame Des Secours, Jbeil, Lebanon. Electronic address:
    Brucellosis is one of the most common zoonotic infections worldwide caused by gram negative bacilli of the genus Brucella. It is transmitted to humans by contact with infected animals or derived food products such as unpasteurized milk. Brucellosis' clinical presentation varies widely from multi-systemic involvement to asymptomatic infection. Read More

    Effect of retrograde colonic electrical stimulation on colonic transit and stress-induced visceral hypersensitivity in rats with irritable bowel syndrome.
    Asian Pac J Trop Med 2017 Aug 24;10(8):827-832. Epub 2017 Aug 24.
    Department of Gastroenterology, Hainan Provincial People's Hospital, Haikou 570311, China. Electronic address:
    Objective: To evaluate the effects of retrograde colonic electrical stimulation (RCES) with trains of short pulses and RCES with long pulses on colonic transit in irritable bowel syndrome (IBS) rats and to investigate whether stress-induced visceral hypersensitivity could be alleviated by RCES so as to find a valuable new approach for IBS treatment.

    Methods: A total of 48 male rats were randomly divided into model group and control group. Visceral hypersensitivity model was induced by a 6-day HIS protocol composed of two stressors, restraint stress for 40 min and forced swimming stress for 20 min. Read More

    Chemical composition, antioxidant, and antibacterial activity of essential oils from Etlingera sayapensis A.D. Poulsen & Ibrahim.
    Asian Pac J Trop Med 2017 Aug 19;10(8):819-826. Epub 2017 Aug 19.
    School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, 43600, Malaysia.
    Objective: To report the chemical composition and bioactivity (including antioxidant and antimicrobial activity) of essential oils from the rhizomes, stems, and leaves of Etlingera sayapensis (E. sayapensis) A.D. Read More

    Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice.
    Asian Pac J Trop Med 2017 Aug 18;10(8):813-818. Epub 2017 Aug 18.
    Department of Respiratory Medicine, First Affiliated Hospital of Hebei Northern College, Zhangjiakou, China. Electronic address:
    Objective: To further explore the function of combine use of tetramethylpyrazine (TMP) and cisplatin (DDP) in lung carcinoma.

    Methods: We used the combination drug to treat Lewis lung cancer mice, investigated the expression level of vascular endothelial growth factor (VEGF), Kruppel-like factor 4 (KLF4) and A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) and to further explore the inhibitory effects and potential mechanism of TMP combined with DDP on tumor angiogenesis.

    Results: The tumor growth was suppressed in TMP group, DDP group and TMP combined with DDP group. Read More

    Nephroprotective effect of Murraya koenigii on cyclophosphamide induced nephrotoxicity in rats.
    Asian Pac J Trop Med 2017 Aug 24;10(8):808-812. Epub 2017 Aug 24.
    Pharmacognosy, Phytochemistry, & Ethnophamacology Laboratory, VNS Group of Institution, Faculty of Pharmacy, VNS Campus, Vidya Vihar, Neelbud, Bhopal, Madhya Pradesh, 462044, India. Electronic address:
    Objective: To evaluate the nephroprotective effect of defatted methanolic extract and aqueous extract of Murraya koenigii (M. koenigii) against cyclophosphamide drug.

    Methods: Nephrotoxicity was induced by cyclophosphamide in 7 days at 150 mg/kg body weight through intraperitoneal route in rat model. Read More

    Epidemiological analysis of 133 malaria cases in Shanxian county, Shandong Province, China.
    Asian Pac J Trop Med 2017 Aug 24;10(8):802-807. Epub 2017 Aug 24.
    Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, No. 11 Taibai Zhong Road, Jining 272033, Shandong, China. Electronic address:
    Objective: To conduct an analysis of the epidemiological changes in malaria that have occurred in Shanxian county from 2002 to 2016.

    Methods: A retrospective study was conducted and data were collected from web-based reporting system to explore the epidemiological characteristics in Shanxian county from 2002 to 2016. All individual case information was obtained from village malaria servicers organized by the local Shandong Institute of Parasitic Diseases. Read More

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