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    1438 results match your criteria Asian Pacific journal of tropical medicine[Journal]

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    Brucellosis: A lymphoma-like presentation.
    Asian Pac J Trop Med 2017 Aug 21;10(8):833-834. Epub 2017 Aug 21.
    Holy Spirit University of Kaslik, Medical School, Lebanon; CHU-Notre Dame Des Secours, Jbeil, Lebanon. Electronic address:
    Brucellosis is one of the most common zoonotic infections worldwide caused by gram negative bacilli of the genus Brucella. It is transmitted to humans by contact with infected animals or derived food products such as unpasteurized milk. Brucellosis' clinical presentation varies widely from multi-systemic involvement to asymptomatic infection. Read More

    Effect of retrograde colonic electrical stimulation on colonic transit and stress-induced visceral hypersensitivity in rats with irritable bowel syndrome.
    Asian Pac J Trop Med 2017 Aug 24;10(8):827-832. Epub 2017 Aug 24.
    Department of Gastroenterology, Hainan Provincial People's Hospital, Haikou 570311, China. Electronic address:
    Objective: To evaluate the effects of retrograde colonic electrical stimulation (RCES) with trains of short pulses and RCES with long pulses on colonic transit in irritable bowel syndrome (IBS) rats and to investigate whether stress-induced visceral hypersensitivity could be alleviated by RCES so as to find a valuable new approach for IBS treatment.

    Methods: A total of 48 male rats were randomly divided into model group and control group. Visceral hypersensitivity model was induced by a 6-day HIS protocol composed of two stressors, restraint stress for 40 min and forced swimming stress for 20 min. Read More

    Chemical composition, antioxidant, and antibacterial activity of essential oils from Etlingera sayapensis A.D. Poulsen & Ibrahim.
    Asian Pac J Trop Med 2017 Aug 19;10(8):819-826. Epub 2017 Aug 19.
    School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, 43600, Malaysia.
    Objective: To report the chemical composition and bioactivity (including antioxidant and antimicrobial activity) of essential oils from the rhizomes, stems, and leaves of Etlingera sayapensis (E. sayapensis) A.D. Read More

    Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice.
    Asian Pac J Trop Med 2017 Aug 18;10(8):813-818. Epub 2017 Aug 18.
    Department of Respiratory Medicine, First Affiliated Hospital of Hebei Northern College, Zhangjiakou, China. Electronic address:
    Objective: To further explore the function of combine use of tetramethylpyrazine (TMP) and cisplatin (DDP) in lung carcinoma.

    Methods: We used the combination drug to treat Lewis lung cancer mice, investigated the expression level of vascular endothelial growth factor (VEGF), Kruppel-like factor 4 (KLF4) and A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) and to further explore the inhibitory effects and potential mechanism of TMP combined with DDP on tumor angiogenesis.

    Results: The tumor growth was suppressed in TMP group, DDP group and TMP combined with DDP group. Read More

    Nephroprotective effect of Murraya koenigii on cyclophosphamide induced nephrotoxicity in rats.
    Asian Pac J Trop Med 2017 Aug 24;10(8):808-812. Epub 2017 Aug 24.
    Pharmacognosy, Phytochemistry, & Ethnophamacology Laboratory, VNS Group of Institution, Faculty of Pharmacy, VNS Campus, Vidya Vihar, Neelbud, Bhopal, Madhya Pradesh, 462044, India. Electronic address:
    Objective: To evaluate the nephroprotective effect of defatted methanolic extract and aqueous extract of Murraya koenigii (M. koenigii) against cyclophosphamide drug.

    Methods: Nephrotoxicity was induced by cyclophosphamide in 7 days at 150 mg/kg body weight through intraperitoneal route in rat model. Read More

    Epidemiological analysis of 133 malaria cases in Shanxian county, Shandong Province, China.
    Asian Pac J Trop Med 2017 Aug 24;10(8):802-807. Epub 2017 Aug 24.
    Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, No. 11 Taibai Zhong Road, Jining 272033, Shandong, China. Electronic address:
    Objective: To conduct an analysis of the epidemiological changes in malaria that have occurred in Shanxian county from 2002 to 2016.

    Methods: A retrospective study was conducted and data were collected from web-based reporting system to explore the epidemiological characteristics in Shanxian county from 2002 to 2016. All individual case information was obtained from village malaria servicers organized by the local Shandong Institute of Parasitic Diseases. Read More

    Measurement of total phenolic content and antioxidant activity of aerial parts of medicinal plant Coronopus didymus.
    Asian Pac J Trop Med 2017 Aug 19;10(8):792-801. Epub 2017 Aug 19.
    Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.
    Objective: To evaluate the total phenolic content and compare the antioxidant activity of various solvent extracts and fractions from the aerial parts of Coronopus didymus through various assays.

    Methods: Total phenolic content was determined using the Folin-Ciocalteu assay and the in vitro antioxidant activity of a number of different extracts was investigated in a dose-dependent manner with three different methods: the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) and ferric reducing antioxidant power (FRAP) assays. A flavone was isolated from the most active ethanolic extract with high antioxidant activity using size exclusion chromatography. Read More

    Growth inhibitory effect of phenolic extracts of Ziziphus jujuba Mill. in dengue vector Aedes aegypti (L) in parent and F1 generation.
    Asian Pac J Trop Med 2017 Aug 19;10(8):787-791. Epub 2017 Aug 19.
    Department of Life Sciences, Dibrugarh University, Dibrugarh, Assam, India. Electronic address:
    Objective: To evaluate the lethal and emergence inhibitory effect of alkaloid, phenolic and terpenoid extracts of Ziziphus jujuba (Rhamnaceae) against Aedes aegypti (Diptera: Culicidae), and to explore the effect of the most effective fraction on developmental and biochemical parameters of the dengue vector.

    Methods: The fourth instar larvae of Ae. aegypti were exposed to alkaloid, phenolic and terpenoid extracts from Z. Read More

    Nitric oxide synthase inhibitors protect against brain and liver damage caused by acute malathion intoxication.
    Asian Pac J Trop Med 2017 Aug 24;10(8):773-786. Epub 2017 Aug 24.
    Department of Pharmacology, National Research Centre, Cairo, Egypt.
    Objective: To investigate the effect of N(G)-nitro-l-arginine methyl ester (l-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, and 7-nitroindazole (7-NI), a selective neuronal NOS inhibitor, on oxidative stress and tissue damage in brain and liver and on DNA damage of peripheral blood lymphocytes in malathion intoxicated rats.

    Methods: Malathion (150 mg/kg) was given intraperitoneally (i.p. Read More

    A single administration of fish oil inhibits the acute inflammatory response in rats.
    Asian Pac J Trop Med 2017 Aug 22;10(8):765-772. Epub 2017 Aug 22.
    Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil. Electronic address:
    Objective: To investigate the antiinflammatory effects of a single administration of fish oil (FO) on the acute inflammatory response.

    Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil (FOP) orally administered in a single dose in rats. Nitric oxide (NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Read More

    Prediction of promiscuous T cell epitopes in RNA dependent RNA polymerase of Chikungunya virus.
    Asian Pac J Trop Med 2017 Aug 19;10(8):760-764. Epub 2017 Aug 19.
    Department of Medical Laboratory Sciences (DMLS), Faculty of Health and Allied Sciences (FHAS), Imperial College of Business Studies (ICBS), Lahore, Pakistan; Department of Microbiology, University of Health Sciences, Lahore, Pakistan.
    Objective: To explore RNA dependent RNA polymerase of Chikungunya virus (CHIKV) and develop T cell based epitopes with high antigenicity and good binding affinity for the human leukocyte antigen (HLA) classes as targets for epitopes based CHIKV vaccine.

    Methods: In this study we downloaded 371 non-structural protein 4 protein sequences of CHIKV belonging to different regions of the world from the US National Institute of Allergy and Infectious Diseases (NIAID) virus pathogen resource database. All the sequences were aligned by using CLUSTALW software and a consensus sequence was developed by using Uni Pro U Gene Software version 1. Read More

    Novel PCR primers to diagnose visceral leishmaniasis using peripheral blood, spleen or bone marrow aspirates.
    Asian Pac J Trop Med 2017 Aug 21;10(8):753-759. Epub 2017 Aug 21.
    Department of Microbiology, University of Dhaka, Dhaka 1000, Bangladesh. Electronic address:
    Objective: To establish a suitable method of diagnosis of visceral leishmaniasis (VL) using peripheral blood, spleen or bone marrow aspirates.

    Methods: Peripheral blood, bone marrow and spleen aspirate samples were collected from clinically suspected VL patients (n = 26). A new PCR primer pair (MK1F/R) was designed targeting kinetoplast mini circle DNA sequences of Leishmania donovani, and Leishmania infantum, and was used to diagnose VL along with some other established primers for VL in polymerase chain reactions. Read More

    Recent research advances on Chromobacterium violaceum.
    Asian Pac J Trop Med 2017 Aug 19;10(8):744-752. Epub 2017 Aug 19.
    Institute of Science, Nirma University, Ahmedabad 382481, India.
    Chromobacterium violaceum is a gram-negative bacterium, which has been used widely in microbiology labs involved in quorum sensing (QS) research. Among the QS-regulated traits of this bacterium, violacein production has received the maximum attention. Violacein production in this organism, however is not under sole control of QS machinery, and other QS-regulated traits of this bacterium also need to be investigated in better detail. Read More

    Medicinal plant products targeting quorum sensing for combating bacterial infections.
    Asian Pac J Trop Med 2017 Aug 19;10(8):729-743. Epub 2017 Aug 19.
    Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, And Genomic Center of Human Pathologies, Mohammed V University, Rabat, Morocco.
    Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Read More

    Domestic reptiles as source of zoonotic bacteria: A mini review.
    Asian Pac J Trop Med 2017 Aug 23;10(8):723-728. Epub 2017 Aug 23.
    Department of Veterinary Science, University of Pisa, I 56124 Pisa, Italy. Electronic address:
    Captive reptiles, always more often present in domestic environment as pets, may harbor and excrete a large variety of zoonotic pathogens. Among them, Salmonella is the most well-known agent, whereas there are very scant data about infections by mycobacteria, chlamydiae and leptospirae in cold-blooded animals. However, the investigations that found antibody reactions and/or the bacteria in samples collected from free-ranging and captive reptiles show that herpetofauna may be involved in the epidemiology of these infections. Read More

    First report on molecular characterization of Leishmania species from cutaneous leishmaniasis patients in southern Khyber Pakhtunkhwa province of Pakistan.
    Asian Pac J Trop Med 2017 Jul 27;10(7):718-721. Epub 2017 Jul 27.
    French Agency for Health and Safety Animal Health Laboratory, Maisons-Alfort, France.
    Objective: To report presence of Leishmania major in Khyber Pakhtunkhwa of Pakistan, where cutaneous leishmaniasis (CL) is endemic and was thought to be caused by Leishmania tropica only.

    Methods: Biopsy samples from 432 CL suspected patients were collected from 3 southern districts of Khyber Pakhtunkhwa during years 2011-2016. Microscopy on Giemsa stained slides were done followed by amplification of the ribosomal internal transcribed spacer 1 gene. Read More

    Effect of axial vertical vibration on degeneration of lumbar intervertebral discs in modified bipedal rats: An in-vivo study.
    Asian Pac J Trop Med 2017 Jul 27;10(7):714-717. Epub 2017 Jul 27.
    Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
    Objective: To assess the effects of axial vibrations on gene expression and lumbar intervertebral disc degeneration in vivo.

    Methods: A modified bipedal rat model was established using a brachial plexus rhizotomy approach to imitate human upright posture. The experimental animals were randomly divided into three groups: control, vertical vibration, and whole-body vibration. Read More

    Clinical study inpatient-reported outcomes after binocular implantation of aspheric intraocular lens of different negative spherical aberrations.
    Asian Pac J Trop Med 2017 Jul 27;10(7):710-713. Epub 2017 Jul 27.
    Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yishan Road, Xuhui District, Shanghai, 200233, China. Electronic address:
    Objective: To compare patient-reported outcomes after implantation of the ZA9003 intraocular lens (IOLs), or the MCX11 ASP IOLs or the spherical IOLs (HQ-201HEP).

    Methods: Prospective nonrandomized controlled trial was used. A total of 105 patients (210 eyes) were divided into three groups according to the type of IOLs: ZA9003 (35 patients, 70 eyes), MCX11 ASP (35 patients, 70 eyes) or HQ-201HEP (35 patients, 70 eyes). Read More

    In vitro inhibitory analysis of consensus siRNAs against NS3 gene of hepatitis C virus 1a genotype.
    Asian Pac J Trop Med 2017 Jul 8;10(7):701-709. Epub 2017 Aug 8.
    Department of Gastroenterology and Hepatology, Fatima Memorial College of Medicine and Dentistry, Shadman, Lahore 54000, Pakistan.
    Objective: To explore inhibitory effects of genome-specific, chemically synthesized siRNAs (small interference RNA) against NS3 gene of hepatitis C virus (HCV) 1a genotype in stable Huh-7 (human hepatoma) cells as well as against viral replication in serum-inoculated Huh-7 cells.

    Methods: Stable Huh-7 cells persistently expressing NS3 gene were produced under antibiotic gentamycin (G418) selection. The cell clones resistant to 1000 μg antibiotic concentration (G418) were picked as stable cell clones. Read More

    Effect of Taoren Quyu Decoction on human endometrial cells and its anti-endometriosis activity in rats.
    Asian Pac J Trop Med 2017 Jul 27;10(7):696-700. Epub 2017 Jul 27.
    Department of Gynaecology and Obstetrics, the First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China. Electronic address:
    Objective: To study the effect of Taoren Quyu Decoction (TQD) on endometrial cells in patients with endometriosis (EMs) and EMs in rats.

    Methods: A total of 60 female Wistar rats were randomly divided into 4 groups, namely, normal group, model group, positive group and TQD group, each group having 15 rats. Except the normal group, EMs model was established in the other three groups by transplanting the rat autologous endometrium. Read More

    Mechanism of antagonistic effects of Andrographis paniculata methanolic extract against Staphylococcus aureus.
    Asian Pac J Trop Med 2017 Jul 29;10(7):685-695. Epub 2017 Jul 29.
    Department of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA (UiTM), Selangor, Malaysia.
    Objective: To investigate the effects of Andrographis paniculata (Burm.f.) Wall. Read More

    Association between FGFR4 gene polymorphism and high-risk HPV infection cervical cancer.
    Asian Pac J Trop Med 2017 Jul 28;10(7):680-684. Epub 2017 Jul 28.
    School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. Electronic address:
    Objectives: To discuss the association between FGFR4 gene polymorphism rs351855 (Glu388Aly) and the susceptibility and chemotherapeutic effect of cervical cancer infected by high-risk type HPV.

    Methods: A total of 162 patients with high-risk HPV cervical cancer and 162 healthy women were collected and the genotypes of the FGFR4 rs351855 locus were detected. The genotype distributions in the two groups were compared. Read More

    Solvent-solvent fractionations of Combretum erythrophyllum (Burch.) leave extract: Studies of their antibacterial, antifungal, antioxidant and cytotoxicity potentials.
    Asian Pac J Trop Med 2017 Jul 28;10(7):670-679. Epub 2017 Jul 28.
    ICBT, Vaal University of Technology, Private Bag X021, Vanderbijlpark, 1900, South Africa.
    Objective: To evaluate the biological activities of Combretum erythrophyllum (C. erythrophyllum) leaf extracts against infectious diseases' pathogenesis and their cytotoxicity potentials.

    Methods: Powdered leaf material (300 g) of C. Read More

    Chemical analysis and in vitro antimicrobial effects and mechanism of action of Trachyspermum copticum essential oil against Escherichia coli.
    Asian Pac J Trop Med 2017 Jul 28;10(7):663-669. Epub 2017 Jul 28.
    Tianjin University of Science & Technology, Tianjin 300222, People's Republic of China. Electronic address:
    Objective: To find a natural plant essential oil (EO) with excellent antimicrobial effects on food-borne bacteria and to explore the mechanism of its antimicrobial function against Escherichia coli (E. coli).

    Methods: The antimicrobial activity of seven EOs against Gram-negative E. Read More

    Production, characterization and biological activities of acidic exopolysaccharide from marine Bacillus amyloliquefaciens 3MS 2017.
    Asian Pac J Trop Med 2017 Jul 28;10(7):652-662. Epub 2017 Jul 28.
    Microbial Biotechnology Department, National Research Centre, Dokki, Cairo, Egypt.
    Objective: To evaluate in-vitro antioxidant, anti-inflammatory and antitumor abilities against human breast adenocarcinoma (MCF7) and human prostate cancer (PC3) as well as the suppressor effect of bacterial exopolysaccharide (BAEPS) on Ehrlich ascites carcinoma (EAC).

    Methods: In-vitro antioxidants characters of BAEPS were determined using various methods, while anti-inflammatory activity was estimated against cyclooxygenase (COX-1 and COX-2). In-vitro study, anticancer against MCF7 and PC3 were assessed by the mitochondrial dependent reduction of yellow MTT. Read More

    GC-MS analysis of volatile compounds of Perilla frutescens Britton var. Japonica accessions: Morphological and seasonal variability.
    Asian Pac J Trop Med 2017 Jul 28;10(7):643-651. Epub 2017 Jul 28.
    Department of Applied Life Science, Konkuk University, Seoul 05029, South Korea. Electronic address:
    Objective: To investigate the composition of volatile compounds in the different accessions of Perilla frutescens (P. frutescens) collected from various habitats of China and Japan.

    Methods: In the present study, the essential oil from the leaves of P. Read More

    Birds and poultries toxoplasmosis in Iran: A systematic review and meta-analysis.
    Asian Pac J Trop Med 2017 Jul 27;10(7):635-642. Epub 2017 Jul 27.
    Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:
    Objective: To evaluate the overall prevalence of Toxoplasma gondii infection among birds and poultries in Iran.

    Methods: Data were systematically collected from 1983 to 2016 in Iran on the following electronic databases: PubMed, Google Scholar, Science Direct, Scopus, Web of Science, Magiran, Irandoc, IranMedex, and Scientific Information Database. Additionally, the abstracts of national scientific congresses and dissertations were included. Read More

    Alternate paradigms on Zika virus-related complications: An analytical review.
    Asian Pac J Trop Med 2017 Jul 28;10(7):631-634. Epub 2017 Jul 28.
    Department of Plant Morphology and Algology, School of Biological Sciences, Madurai Kamaraj University, Madurai 21, Tamil Nadu, India.
    The proportion of the reported cases of Zika virus (ZIKV) infection reached the status of a pandemic. Numerous studies are being conducted on the isolation of ZIKV strains from various epidemics, diagnosis of the infections, various animal models and cell culture designs to study the pathogenesis of ZIKV in the attempts to find an effective ZIKV vaccine. This review focuses upon the 'Off-Spectrum' body of studies which analyses the epidemiology, pathogenesis and other attributes of ZIKV in the light of various dissident hypotheses. Read More

    Research advances on the multiple uses of Moringa oleifera: A sustainable alternative for socially neglected population.
    Asian Pac J Trop Med 2017 Jul 28;10(7):621-630. Epub 2017 Jul 28.
    Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Center, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Veterinary Medicine, Postgraduate Program in Veterinary Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
    Moringa oleifera Lam (Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Read More

    Exploring on the elderly health management model in tropic area.
    Asian Pac J Trop Med 2017 Jun 15;10(6):614-618. Epub 2017 Jun 15.
    The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570201, China.
    In this article, based on the characteristics of tropical area, we analyze the beneficial and the disadvantage of tropical area to human health, points out the existing problems in elderly health management pattern in the tropics area, accordingly we discuss how to establish tropical characterized elderly health management, and put forward constructive suggestions. Read More

    Doubled dosage of sofosbuvir is expected for inhibiting Zika virus infection.
    Asian Pac J Trop Med 2017 Jun 15;10(6):612-613. Epub 2017 Jun 15.
    Hainan Medical University, China; Dr DY Patil University, India; Faculty of Medicine, University of Nis, Serbia; Joseph Ayobabalola University, Nigeria.
    Sofosbuvir is a new antiviral drug that has been recommended for management of hepatitis C virus (HCV) for a few years. New researches support that sofosbuvir might be useful for the management of Zika virus infection. Based on the pharmacological activity, inhibiting the HCV RNA-dependent RNA polymerase (RdRp or NS5 protein), sofosbuvir is proposed for its effectiveness against Zika virus infection. Read More

    The relationship between fractional anisotropy value and tumor microarchitecture in late-stage rat glioma.
    Asian Pac J Trop Med 2017 Jun 15;10(6):607-611. Epub 2017 Jun 15.
    Department of Radiology, Kangya Hospital, Yiyang, Hunan, PR China.
    Objective: To explore the magnetic resonance diffusion tensor imaging (MR-DTI) features of in the late stage of Wistar rat C6 brain glioma, and the relationship between fractional anisotropy value and tumor microarchitecture.

    Methods: The concentration of more than 1.0 × 10(6)/10 μL glioma cells and complete medium were injected stereotactically into the right caudate nucleus of the experimental group (n = 35) and control group (n = 10), respectively. Read More

    Comparison of phenolic components and biological activities of two Centaurea sp. obtained by three extraction techniques.
    Asian Pac J Trop Med 2017 Jun 15;10(6):599-606. Epub 2017 Jun 15.
    Akdeniz University, Science Faculty, Department of Biology, 07058 Antalya, Turkey.
    Objective: The present study aimed to compare the polyphenol content, total phenolic, total flavonoid, antioxidant and antimicrobial activity of the extracts obtained from Centaurea amaena Boiss. & Balansa and Centaurea aksoyi Hamzaoğlu & Budak.

    Methods: Both species were subjected to maceration, Soxhlet and ultrasonication extractions with methanol in order to macerated (ME), Soxhlet (SE) and ultrasonicated (UE) extracts. Read More

    Intervention effect and mechanism of curcumin in chronic urinary tract infection in rats.
    Asian Pac J Trop Med 2017 Jun 15;10(6):594-598. Epub 2017 Jun 15.
    Urinary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China.
    Objective: To analyze the invention effect of curcumin on chronic urinary tract infection in rats and explore its possible mechanism of action.

    Methods: The experimental animals were randomly divided into three groups, normal, model and curcumin group. Chronic urinary tract infection models were built for model group and curcumin group by injecting coliform fluid into the cavity of bladder. Read More

    Antioxidant and hepatoprotective potentials of novel endophytic fungus Achaetomium sp., from Euphorbia hirta.
    Asian Pac J Trop Med 2017 Jun 15;10(6):588-593. Epub 2017 Jun 15.
    Department of Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore 14, Tamil Nadu, India. Electronic address:
    Objective: To isolate, identify and evaluate the antioxidant, antimicrobial, hepatoprotective potentials, total phenolic content, flavonoid content, tannin content of ethyl acetate extract of endophytic fungus Achaetomium sp., isolated from Euphorbia hirta.

    Methods: Hepatoprotectivity of ethyl acetate extract of Achaetomium sp. Read More

    Atractylenolide Ⅰ protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect.
    Asian Pac J Trop Med 2017 Jun 16;10(6):582-587. Epub 2017 Jun 16.
    Department of Dermatology, The 6th Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:
    Objective: To investigate whether atractylenolide Ⅰ (ATL-Ⅰ) has protective effect on lipopolysaccharide (LPS)-induced disseminated intravascular coagulation (DIC) in vivo and in vitro, and explore whether NF-κB signaling pathway is involved in ATL-Ⅰ treatment.

    Methods: New Zealand white rabbits were injected with LPS through marginal ear vein over a period of 6 h at a rate of 600 μg/kg (10 mL/h). Similarly, in the treatment groups, 1. Read More

    In vitro and in vivo cytochrome P450 3A enzyme inhibition by Aframomum melegueta and Denniettia tripetala extracts.
    Asian Pac J Trop Med 2017 Jun 16;10(6):576-581. Epub 2017 Jun 16.
    Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria.
    Objective: To evaluate the in vitro and in vivo inhibitory effects of two commonly used herbs, Aframomum melegueta (A. melengueta) and Dennettia tripetala (D. tripetala) on CYP 3A enzymes. Read More

    Experimental study on the apoptosis of cervical cancer Hela cells induced by juglone through c-Jun N-terminal kinase/c-Jun pathway.
    Asian Pac J Trop Med 2017 Jun 15;10(6):572-575. Epub 2017 Jun 15.
    Affiliated Hospital of Hainan Medical University, Haikou 570102, China.
    Objective: To study the regulatory effect and molecular mechanism of juglone on apoptosis of cervical cancer Hela cells.

    Methods: Cervical cancer Hela cells were cultured and treated with different dosages of juglone (10, 20, and 40 μmol/L, respectively) and c-Jun N-terminal kinase (JNK) inhibitor SP600125 (10, 20, and 40 μmol/L, respectively). Then cellular proliferative activity and the expression of JNK/c-Jun pathway molecule and apoptotic molecule in the cells were detected. Read More

    Anticancer activity test of ethyl acetate extract of endophytic fungi isolated from soursop leaf (Annona muricata L.).
    Asian Pac J Trop Med 2017 Jun 20;10(6):566-571. Epub 2017 Jun 20.
    Department of Biochemistry, Faculty of Mathematics and Sciences, Bogor Agricultural University, Darmaga Campus, Bogor 16680, Indonesia.
    Objective: To analyze anticancer activity of an ethyl acetate extract of endophytic fungi isolated from soursop leaf (Annona muricata L.).

    Methods: Anticancer activity of fungal extracts was determined by observing its toxicity against MCF-7 (Michigan Cancer Foundation-7) cells in vitro by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay method. Read More

    Protective effects of Balanites aegyptiaca extract, Melatonin and Ursodeoxycholic acid against hepatotoxicity induced by Methotrexate in male rats.
    Asian Pac J Trop Med 2017 Jun 15;10(6):557-565. Epub 2017 Jun 15.
    Faculty of Science, Department of Zoology, Cairo University, Giza 12631, Egypt.
    Objective: To compare the degree of ameliorative effects of Melatonin (MEL), Ursodeoxycholic acid (UDCA) and Balanites aegyptiaca (BA) against hepatotoxicity induced by MTX for one month.

    Methods: Eighty adult male rats (Sprague Dawely) weighing (190 ± 10 g), were randomly divided into eight equal groups: Control, MTX, MEL, BA, UDCA, MTX + MEL, MTX + BA, MTX + UDCA. Liver function biomarker enzymes, liver tissue oxidative stress parameters, together with total antioxidant capacity and tumor necrosis factor (TNF-α) were determined. Read More

    Xanthine oxidase inhibitors from Archidendron clypearia (Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants.
    Asian Pac J Trop Med 2017 Jun 15;10(6):549-556. Epub 2017 Jun 15.
    Department of Pharmacology, Hanoi University of Pharmacy, 13 Le Thanh Tong, Hoan Kiem, Hanoi, Viet Nam. Electronic address:
    Objective: To screen Vietnamese medicinal plants for xanthine oxidase (XO) inhibitory activity and to isolate XO inhibitor(s) from the most active plant.

    Methods: The plants materials were extracted by methanol. The active plant materials were fractionated using different organic solvents, including n-hexane, ethyl acetate, and n-butanol. Read More

    Promising antileishmanial effectiveness of doxorubicin and Doxil against Leishmania major: An in vitro assay.
    Asian Pac J Trop Med 2017 Jun 19;10(6):544-548. Epub 2017 Jun 19.
    Students Research Committee, Department of Parasitology and Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Objective: To evaluate the effect of doxorubicin and its pegylated liposomal formulation (Doxil, Caelyx) on in vitro susceptibility of promastigote and amastigote stages of Leishmania major.

    Methods: Throughout in vitro assays the IC50 was calculated in the promastigotes and amastigotes forms in J774 macrophage cell line. Also as cytotoxicity in J774 cell line macrophages. Read More

    Effect of dietary supplementation with olive and sunflower oils on lipid profile and liver histology in rats fed high cholesterol diet.
    Asian Pac J Trop Med 2017 Jun 15;10(6):539-543. Epub 2017 Jun 15.
    Departamento de Bioquímica e Biologia Molecular, Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria (UFSM), Campus Universitário - Camobi, 97105-900 Santa Maria, RS, Brazil.
    Objective: To compare the effects of high-monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) against the metabolic disorders elicited by a high-cholesterol diet (HC) in rats.

    Methods: Using in vivo dietary manipulation, rats were fed with different diets containing 4% soybean oil (cholesterol free diet) and 1% HC containing 12% olive oil (HC + OO) enriched with MUFA and 12% sunflower oil (HC + SO) enriched with PUFA for 60 d. Serum lipid levels and hepatic steatosis were evaluated after the treatment period. Read More

    In silico identification and characterization of common epitope-based peptide vaccine for Nipah and Hendra viruses.
    Asian Pac J Trop Med 2017 Jun 1;10(6):529-538. Epub 2017 Jul 1.
    Department of Genetic Engineering & Biotechnology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh. Electronic address:
    Objective: To explore a common B- and T-cell epitope-based vaccine that can elicit an immune response against encephalitis causing genus Henipaviruses, Hendra virus (HeV) and Nipah virus (NiV).

    Methods: Membrane proteins F, G and M of HeV and NiV were retrieved from the protein database and subjected to different bioinformatics tools to predict antigenic B-cell epitopes. Best B-cell epitopes were then analyzed to predict their T-cell antigenic potentiality. Read More

    Genetic diversity and phylogenetic analysis of EG95 sequences of Echinococcus granulosus: Implications for EG95 vaccine application.
    Asian Pac J Trop Med 2017 May 18;10(5):524-527. Epub 2017 May 18.
    Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Laboratory of Infection and Immunity, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, PR China. Electronic address:
    Objective: To analyse the genetic variability of EG95 sequences and provide guidance for EG95 vaccine application against Echinococcus granulosus (E. granulosus).

    Methods: We analysed EG95 polymorphism by collecting total 97 different E. Read More

    Pyrrolidine dithiocarbamate alleviates the anti-tuberculosis drug-induced liver injury through JAK2/STAT3 signaling pathway: An experimental study.
    Asian Pac J Trop Med 2017 May 19;10(5):520-523. Epub 2017 May 19.
    Laboratory Department, Linyi Chest Hospital in Shandong Province, Linyi City, Shandong Province 276034, China. Electronic address:
    Objective: To study the effect of pyrrolidine dithiocarbamate (PDTC) on the anti-tuberculosis drug-induced liver injury and the molecular mechanism.

    Methods: Clean male SD rats were selected as experimental animals and randomly divided into normal group, model group, PDTC group and AG490 group. Animal model of anti-tuberculosis drug-induced liver injury was established by intragastric administration isoniazid + rifampicin. Read More

    Matrine inhibits bladder cancer cell growth and invasion in vitro through PI3K/AKT signaling pathway: An experimental study.
    Asian Pac J Trop Med 2017 May 17;10(5):515-519. Epub 2017 May 17.
    Department of Urology, First Affiliated Hospital of PLA General Hospital, Beijing 100048, China. Electronic address:
    Objective: To study the inhibitory effect of matrine on bladder cancer cell growth and invasion in vitro through PI3K/AKT signaling pathway.

    Methods: Human T24 bladder cancer cell lines were cultured and treated with different doses of matrine (0.25 mg/mL, 0. Read More

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