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    9174 results match your criteria Asian Pacific journal of cancer prevention : APJCP[Journal]

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    Comparison of Diagnostic Yield of a FISH Panel Against Conventional Cytogenetic Studies for Hematological Malignancies: A South Indian Referral Laboratory Analysis Of 201 Cases
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3457-3464. Epub 2017 Dec 29.
    Department of Cytogenetics, Anand Diagnostic Laboratory, Bangalore, India. Email:
    Objectives: Genetic markers are crucial fort diagnostic and prognostic investigation of hematological malignancies (HM). The conventional cytogenetic study (CCS) has been the gold standard for more than five decades. However, FISH (Fluorescence in Situ Hybridization) testing has become a popular modality owing to its targeted approach and the ability to detect abnormalities in non-mitotic cells. Read More

    Cancer Detection in Microarray Data Using a Modified Cat Swarm Optimization Clustering Approach
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3451-3455. Epub 2017 Dec 29.
    Department of Computer Science and Engineering, Bannari Amman Institute of Technology, Sathyamangalam, Erode, India. Email:
    Objective: A better understanding of functional genomics can be obtained by extracting patterns hidden in gene expression data. This could have paramount implications for cancer diagnosis, gene treatments and other domains. Clustering may reveal natural structures and identify interesting patterns in underlying data. Read More

    Genistein and Trichostatin A Induction of Estrogen Receptor Alpha Gene Expression, Apoptosis and Cell Growth Inhibition in Hepatocellular Carcinoma HepG 2 Cells
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3445-3450. Epub 2017 Dec 29.
    Research Center for Non-communicable Diseases, Jahrom University of Medical sciences, Jahrom, Iran. Email:
    Epigenetic changes such as DNA methylation and histone acetylation play important roles in determining gene expression. Hypermethylation of CpG islands of the promoter region of tumor suppressor genes can greatly influence carcinogenesis through transcriptional silencing. Acetylation of lysine in histone tails causes relaxation of chromatin, which facilitates gene transcription, while deacetylation is associated with condensed chromatin resulting in gene silencing. Read More

    Dosimetric Validation of Volumetric Modulated Arc Therapy with Three 6MV Beam-Matched Linear Accelerators
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3439-3444. Epub 2017 Dec 29.
    Research and Development center, Bharathiar University, Coimbatore, India.
    Background: To avoid inconvenience to patients due to linear accelerator down time in busy radio-therapy departments, treatment plans can be switched between linear accelerators provided that all exhibit the same same dosimetric characteristics. In other words linear accelerators should be beam-matched. Aim: The aim of this study was to evaluate the clinical significance of beam-matching using VMAT plans. Read More

    EpCAM-based Flow Cytometric Detection of Circulating Tumor Cells in Gallbladder Carcinoma Cases
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3429-3437. Epub 2017 Dec 29.
    Department of Pathology,Dr. Ram Manohar Lohia Institute of Medical Sciences, Gomti Nagar, Lucknow-226010, India. Email:
    Purpose: Liquid biopsy has entered the arena of cancer diagnostics in the past decade and detection of circulating tumor cells (CTC) is one diagnostic component. CTCs in gallbladder cancer (GBC) have hitherto not been comprehensively analysed. Methods and Results: The current study focused on the diagnostic role of CTCs in 27 cases of treatment-naive GBC and 6 normal controls as well as 6 cases of cholecystitis. Read More

    TP53 Gene Pro72Arg (rs1042522) Single Nucleotide Polymorphism as Not a Risk Factor for Colorectal Cancer in the Iranian Azari Population
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3423-3427. Epub 2017 Dec 29.
    Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Email:
    Background: The p53 protein participates critically in several cellular functions such as cell growth and DNA repair. Polymorphisms in the TP53 locus have repeatedly been implicated in the pathogenesis of cancers all over the world. Over 200 single nucleotide polymorphisms (SNPs) have been characterized, but one well-known example at at codon 72, Pro72Arg (rs1042522), has the displayed inconsistent results with regard to cancer risk. Read More

    Vitamin D Deficiency Associated with Differentiated Thyroid Carcinoma: A Case- Control Study
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3419-3422. Epub 2017 Dec 29.
    Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran. Email:
    Objective: In recent decades, the incidence of thyroid cancer has increased throughout the world. It is unclear whether factors such as vitamin D deficiency may have been involved in this increase. The present case-control study was conducted to examine any association between Vitamin D deficiency and thyroid cancers. Read More

    Unexpected Lower Expression of Oncoprotein Gankyrin in Drug Resistant ABCG2 Overexpressing Breast Cancer Cell Lines
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3413-3418. Epub 2017 Dec 29.
    Department of Biochemistry, Faculty of Science, Payam Noor University of Mashhad, Mashhad, Iran.
    Background: Development of a multidrug resistance (MDR) phenotype to chemotherapy remains a major barrier in the treatment of cancer. Gankyrin (p28, p28GANK or PSMD10) is an oncoprotein overexpressed in different carcinoma cell lines. The aim of this study was to compare Gankyrin expression level in MDR cells (MCF-7/ADR and MCF-7/ MX) and non-MDR counterparts (MCF-7). Read More

    Descriptive Epidemiology of Cancers in Togo from 2009 to 2016
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3407-3411. Epub 2017 Dec 29.
    Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo. Email :
    Background: Cancer is a global public health problem. According to World Report on Cancer in 2000, developing countries are becoming increasingly affected. Methods: This retrospective and descriptive 8-year study of all histological confirmed cancers was conducted using data from the anatomical pathology laboratory registry of Togo’s only laboratory. Read More

    Cancer Mortality, Early Detection and Treatment among Adult New Zealanders: Changes in Perceptions between 2001 and 2014/5
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3401-3406. Epub 2017 Dec 29.
    Cancer Society Social and Behavioural Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. Email:
    Background: Beliefs about cancer risk and experience of early detection and treatment can impact on willingness to engage with these initiatives. This study describes changes in perceptions of cancer mortality, early detection and treatment among adult New Zealanders (NZ) between two cross-sectional studies conducted in 2001 and 2014/5. Methods: Data was collected via telephone interviews conducted by trained interviewers in 2001 (231 females and 207 males, 64% response rate) and 2014/5 (588 females and 476 males, 64% response rate). Read More

    Lung Lesion Detection in CT Scan Images Using the Fuzzy Local Information Cluster Means (FLICM) Automatic Segmentation Algorithm and Back Propagation Network Classification
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3395-3399. Epub 2017 Dec 29.
    Department of Electrical and Electronics Engineering, Saveetha School of Engineering, Saveetha University, Thandalam, Chennai-602 105, India. Email:
    Lung cancer is a frequently lethal disease often causing death of human beings at an early age because of uncontrolled cell growth in the lung tissues. The diagnostic methods available are less than effective for detection of cancer. Therefore an automatic lesion segmentation method with computed tomography (CT) scans has been developed. Read More

    Cox Regression and Parametric Models: Comparison of How They Determine Factors Influencing Survival of Patients with Non-Small Cell Lung Carcinoma
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3389-3393. Epub 2017 Dec 29.
    Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Safayeh, Yazd, Iran. Email:
    Background and objectives: The present study of survival rate of patients with non-small cell carcinoma (NSCLC) compared the efficiency of Cox semi-parametric vs. parametric models in determination of influencing factors. Methods: In this retrospective cohort study, data were gathered from 190 patients with a confirmed diagnosis of NSCLC referred to Shahid Sadoughi and Shohadaye Kargar Hospitals in Yazd, Iran during 2005 to 2014. Read More

    Limited Understanding of Pap Smear Testing among Women, a Barrier to Cervical Cancer Screening in the United Arab Emirates
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3379-3387. Epub 2017 Dec 29.
    Primary Health Care Sector, Dubai Health Authority, Dubai, United Arab Emirates. Email:
    Global data indicate that cervical cancer is the fourth most common cancer among women worldwide. Important factors that affect interventions for early diagnosis of cervical cancer include social beliefs and values and poor knowledge. These may contribute to women’s participation in screening for cervical cancer and have a significant impact on decisions to take preventive action. Read More

    Human Papilloma Virus Genotype Distribution in Cervical lesions in Zanjan, Iran
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3373-3377. Epub 2017 Dec 29.
    Razi Vaccine and Serum Research Institute, Karaj, Alborz. Email:
    Objective: Cervical cancer is one of the most common cancers among women all over the world, and main cause is persistent infection with high risk human papillomavirus (HPV) strains. It has been reported that the distribution and prevalence of HPV types varies by geographical region, so that this is important for prevention by type-specific vaccines. The aim of current study was to determine the genotype distribution of HPV using the INNO-LiPA genotyping assay in Zanjan province, North West Iran. Read More

    Treatment-Related Quality of Life in Nepalese Women with Breast Cancer
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3365-3371. Epub 2017 Dec 29.
    Faculty of Nursing, Mahidol University, Bangkok, Thailand. Email:
    Objective: To identify the level of quality of life and its predictors in Nepalese women with breast cancer while receiving chemotherapy. Methods: This cross-sectional study with a predictive design was conducted for a conveniently selected sample of 85 Nepalese women with primary breast cancer receiving chemotherapy at outpatient clinics of three cancer hospitals of Kathmandu, Nepal. Data were collected during December 2016 and February 2017 using demographic sheets, the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire and the modified Medical Outcomes Study Social Support Survey. Read More

    Protein-Protein Interaction Network Analysis for a Biomarker Panel Related to Human Esophageal Adenocarcinoma
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3357-3363. Epub 2017 Dec 29.
    Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Email:
    Background: Esophageal adenocarcinoma (EAC) is one of the mostlethal cancers in the world with a very poor prognosis. Identification of molecular diagnostic methods is an important goal. Since protein-protein interaction (PPI) network analysis is a suitable method for molecular assessment, in the present research a PPI network related to EAC was targeted. Read More

    Low Body Mass Index Is an Independent Predictive Factor after Surgical Resection in Patients with Non-Small Cell Lung Cancer
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3353-3356. Epub 2017 Dec 29.
    Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, Japan. Email:
    Background: The effect of body mass index (BMI) on postoperative survival in non-small cell lung cancer (NSCLC) has been controversial. We retrospectively analysed the effect of preoperative BMI on postoperative outcomes of NSCLC surgery. Methods: Consecutive 384 NSCLC patients were enrolled. Read More

    Synergistic Effect of Forbesione From Garcinia hanburyi in Combination with 5-Fluorouracil on Cholangiocarcinoma
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3343-3351. Epub 2017 Dec 29.
    Department of Microbiology, Khon Kaen University, Khon Kaen 40002, Thailand.
    Background: Chemotherapy for advanced cholangiocarcinoma (CCA) is largely ineffective; thus innovative combinations of chemotherapeutic agents and natural compounds represent a promising strategy. This study aimed to investigate the synergistic effects of forbesione combined with 5-fluorouracil (5-FU) in hamster cholangiocarcinoma (Ham-1) cells both in vitro and in vivo. The anti-tumor effects of 5-FU combined with forbesione in vitro were determined using the Sulforhodamine B (SRB) assay and the effects in vivo were assessed in transplanted Ham-1 allograph models. Read More

    Effects of Damnacanthal and Nordamnacanthal on Proliferation, Apoptosis, and Migration of Oral Squamous Cell Carcinoma Cells
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3333-3341. Epub 2017 Dec 29.
    Department of Oral and craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.Email:
    Cancer is one of the most common causes of death in the developed world, with one-third of people diagnosed with cancer during their lifetime. Oral cancer commonly occurs involving the buccal mucosa (cheeks), tongue, floor of the mouth and lip. It is one of the most devastating and disfiguring of malignancies. Read More

    Quality of Life Determinants in Breast Cancer Patients in Central Rural India
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3325-3332. Epub 2017 Dec 29.
    Department of Psychiatry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, India. Email:
    Introduction: Breast cancer is the most frequently diagnosed cancer among women throughout world, with incidence rates increasing in India. Improved survival in breast cancer patients has resulted in their quality of life (QOL) becoming an important issue. Identifying determinants for QOL may provide insights into how to improve their living conditions. Read More

    Almost Complete Lack of Human Cytomegalovirus and Human papillomaviruses Genome in Benign and Malignant Breast Lesions in Shiraz, Southwest of Iran
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3319-3324. Epub 2017 Dec 29.
    Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Email:
    Breast cancer ranks as the most common cancer among women worldwide. There have been controversial reports regarding contributions of human papillomaviruses (HPVs) and human cytomegalovirus (HCMV) to its development. The aim of this study was to determine the frequency of HPV and HCMV positivity in benign and malignant breast tumors. Read More

    Comparison of Salivary Antioxidants in Children with Primary Tooth Abscesses before and after Treatment in Comparison with Healthy Subjects
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3315-3318. Epub 2017 Dec 29.
    Department of Clinical Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.Email:
    Aim: The aim of this study was to compare the total antioxidant capacity (TAC) of children with primary molar abscesses before and two weeks after extraction of the infected tooth. Materials and methods: Forty one children aged between 3-6 years participatesd in this cross sectional study. The antioxidant activity of saliva was investigated in 20 patients with tooth abscesses affecting one of the first primary molars before and after tooth extraction in the case group and once in 21 children with no caries or dental problems in the control group. Read More

    Utility of 5-Methylcytosine Immunohistochemical Staining to Assess Global DNA Methylation and Its Prognostic Impact in MDS Patients
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3307-3313. Epub 2017 Dec 29.
    Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. Email:
    Background: DNA methylation plays a vital role in the pathogenesis of the myelodysplastic syndrome (MDS), a heterogeneous group of clonal hematopoietic stem cell (HSC) disorders. It is reported to be an independent prognostic factor affecting overall survival (OS). Our aim was to analyze the role of global DNA methylation using an anti-5-methylcytosine (5-MC) antibody by immunohistochemistry (IHC) of bone marrow biopsy (BM Bx) specimens in MDS patients, assessing correlations with various clinical and biological prognostic factors. Read More

    Astrocyte Elevated Gene 1 (AEG-1): A Promising Candidate for Molecular Targeted Therapy in Oral Squamous Cell Carcinomas
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3301-3305. Epub 2017 Dec 29.
    Dental Materials Research Center, Institute of Health, Babol University of Medical Siences, Babol, Iran. E-mail:
    Background: Astrocyte elevated gene 1 (AEG-1), also known as metadherin, is an oncogene which is overexpressed in various types of cancer, playing important roles in invasion, metastasis, angiogenesis and chemotherapy resistance. Hence it might be used as a therapeutic target. The aim of this study was to evaluate the expression of AEG-1 as a novel molecular marker in oral squamous cell carcinomas and establish correlations with clinicopathologic factors. Read More

    BRCA1 Promoter Methylation and Expression - Associations with ER+, PR+ and HER2+ Subtypes of Breast Carcinoma
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3293-3299. Epub 2017 Dec 29.
    Department of Pathology, University Of Delhi, Delhi, India. Email:
    Introduction: Considering the increasing trend in incidence rates, morbidity and mortality of breast cancer, there is an urgent need to identify and validate new biomarkers for early detection and better management. The purpose of the study was to investigate BRCA1 protein expression and promoter methylation of the BRCA1 gene and their association with molecular subtypes based on estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) positivity. Materials and Methods: A total of 114 breast cancer tissue biopsies were collected for methylation specific PCR (MSP) and immunohistochemical (IHC) analysis. Read More

    Prognostic Significance of Indicators of Systemic Inflammatory Responses in Glioblastoma Patients
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3287-3291. Epub 2017 Dec 29.
    Medstar Antalya Hospital, Department of Radiation Oncology, Antalya, Turkey. Email:
    Background: High-grade gliomas, with glioblastomas as the most frequently observed histologic subtype, are the most common primary brain tumours in adults. It is considered that inflammatory responses play a major role in malignancies, including tumour progression. This study aimed to determine the prognostic significance of the neutrophil to lymphocyte ratio (NLR) and the thrombocyte to lymphocyte ratio (PLR) as indicators of systemic inflammatory response (SIR) in glioblastoma patients. Read More

    The Correlates of Kidney Dysfunction – Tumour Nephrectomy Database (CKD-TUNED) Study: Protocol for a Prospective Observational Study
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3281-3285. Epub 2017 Dec 29.
    Kidney Disease Research Group, Diamantina Institute, Faculty of Medicine, University of Queensland, Brisbane, Australia.
    Background: Tumour nephrectomy conveys a significant risk of adverse renal functional outcomes postoperatively, however there are limited strategies for predicting patients at increased risk of these outcomes. The Correlates of Kidney Dysfunction – Tumour Nephrectomy Database (CKD-TUNED) study is a prospective observational study evaluating the risk of chronic kidney disease and end-stage kidney disease in tumour nephrectomy patients. Methods: The CKDTUNED study involves analysis of clinical data and collection of tissue, urine and blood samples for the purposes of forming a tissue repository resource for future investigation. Read More

    Aloe-Emodin Influence on the Lysosomal Compartment of Hela Cells
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3273-3279. Epub 2017 Dec 29.
    Department of Cell Biology and Electron Microscopy, Institute of Biology, The Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland. Email:
    Background: Aloe-emodin belongs to the group of anthraquinones having extremely high biological activity. The aim of this study was to evaluate the range of morphological and biochemical changes in HeLa cells treated with aloe-emodin, especially with regard to the lysosomal compartment. Methods: Marking of lysosomes was performed with neutral red staining for conventional light microscopy and acridine orange staining for confocal microscopy. Read More

    Seroepidemiological Study of Hepatitis B, C and HIV among Blood Donors in Kerman
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3267-3272. Epub 2017 Dec 29.
    Department of Medical Microbiology , Kerman University of Medical Sciences, Kerman,Iran.Email:
    Background: Infections transmitted through blood transfusions are the most important issue associated with blood donation. We aimed to provide an assessment of the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kerman province of Iran. Methods: Between 2014-2016, 99,187 samples were examined in a retrospective study in five blood transfusion centers in Kerman province. Read More

    Knowledge and Perceptions about Cancer Treatment-associated Infertility among Young Patients at a Tertiary Care Hospital in Pakistan
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3261-3265. Epub 2017 Dec 29.
    Department of Clinical Oncology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan. Email:
    Introduction: Infertility after cancer treatment can cause significant emotional stress and grief for cancer survivors. In this study we assessed knowledge and perceptions among young cancer patients regarding the topic of cancer and infertility related to different treatment options. Material and Methods: This cross-sectional study was conducted on young cancer patients in the Clinical Oncology Department, JPMC, Karachi, from January to August 2013. Read More

    Phosphorylated Akt Protein at Ser473 Enables HeLa Cells to Tolerate Nutrient-Deprived Conditions
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3255-3260. Epub 2017 Dec 29.
    Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
    Background: Despite angiogenesis, many tumours remain hypovascular and starved of nutrients while continuing to grow rapidly. The specific biochemical mechanisms associated with starvation resistance, austerity, may be new biological characters of cancer that are critical for cancer progression. Objective: This study aim was to investigate the effect of nutrient starvation on HeLa cells and the possible mechanism by which the cells are able to tolerate nutrient-deprived conditions. Read More

    Inter- and Intra-Observer Variability in Diagnosis of Oral Dysplasia
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3251-3254. Epub 2017 Dec 29.
    Department of Oral Medicine and Radiology, K.L.E.Society’s Institute of Dental Sciences, Bangalore, India.Email:
    Background: Oral potentially malignant disorders (OPMDs) are lesions from which malignancy is more likely to develop that from other tissues. The potential for malignant transformation of OPMDs is estimated by determining the degree of dysplastic changes in the epithelium. Dysplasia grading has been criticized for lack of reproducibility and poor predictive value but is still considered the gold standard for diagnosing OPMDs. Read More

    Lack of Associations between TLR9 and MYD88 Gene Polymorphisms and Risk of Chronic Lymphocytic Leukemia
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3245-3250. Epub 2017 Dec 29.
    Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.Email:
    Background: Genetic factors like single nucleotide polymorphisms (SNPs) may play an important role in the etiology of chronic lymphocytic leukemia (CLL). Mutations in Toll like receptor 9 (TLR9) and myeloid differentiation primary response 88 (MYD88) genes may lead to an abnormal immune response that may cause greater cell proliferation and thus alter an individual’s susceptibility to haematological malignancies including CLL. Objective: This work was designed to study any association of the TLR9 (rs2066807C/G and rs187084T/C) and MYD88 (L265P) single nucleotide polymorphism (SNPs) with risk of CLL in Egyptians. Read More

    Risk Factors for Invasive Fungal Infection among Thai Oncologic Patients with Febrile Neutropenia and Cutaneous Presentation: A 5-Year Retrospective Study in Southern Thailand
    Asian Pac J Cancer Prev 2017 Dec 29;18(12):3239-3243. Epub 2017 Dec 29.
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand. Email:
    Background: Febrile neutropenia (FNP) is a condition defined by fever and neutropenia. There are current only limited data on related cutaneous manifestations. This study aimed to assess cutaneous lesions and their etiologies in a Thai group of FNP patients. Read More

    Cellular and Molecular Changes in MNU-Induced Breast Tumours Injected with PF4 or bFGF
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3231-3238. Epub 2017 Dec 28.
    Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kota Bharu, Kelantan, Malaysia. Email:
    Background: Angiogenic activity has been considered to reflect important molecular events during breast tumour development. The present study concerned cellular and molecular changes of MNU-induced breast tumours subjected to promotion and suppression of angiogenesis. Methods: Female Sprague Dawley rats at the age of 21 days received MNU at the dose 70 mg/kg of body weight by intraperitoneal injection. Read More

    Concentration- Dependent Effects of Curcumin on 5-Fluorouracil Efficacy in Bladder Cancer Cells
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3225-3230. Epub 2017 Dec 28.
    Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Email:
    Purpose: Curcumin (Cur), a herbal ingredient with anticancer properties, has been shown to inhibit growth of malignant cells in vivo and in vitro. However, studies on combination therapy of Cur with chemotherapeutic drugs have been limited. Here, effects of Cur on the cytotoxicity of 5-Fluorouracil (FU) were investigated with epithelial bladder cancer cells (EJ138) in vitro. Read More

    Knowledge, Attitudes, Preventive Practices and Screening Intention about Colorectal Cancer and the Related Factors among Residents in Guangzhou, China
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3217-3223. Epub 2017 Dec 28.
    Department of Statistics and Epidemiology,School of Public Health, Sun Yat-sen University, China. Email:
    Background: In Guangzhou, China, colorectal cancer (CRC) is the second most commonly diagnosed cancer. The government initiated a CRC screening program in 2015, and investigating the knowledge, attitudes, and practices toward CRC would help facilitate the participation of the program. Methods: A cross-sectional survey was conducted from October 2014 to September 2015. Read More

    Pattern of Pediatric Oncology Cases in the Western Region of Nepal
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3213-3215. Epub 2017 Dec 28.
    Department of Radiation Oncology, Manipal College of Medical Sciences and Cancer Research Center, Pokhara, Nepal. Email:
    Childhood cancers form a rare and heterogeneous group which fortunately have a higher cure rate than adult cancers. A few non-profit organizations in Nepal have extended support to help patients suffering from cancer, but their main focus has been on adults. The objective of this study was to establish the pattern of childhood cancers in the Western region of Nepal. Read More

    Positive Effects of Cognitive Behavioral Therapy on Depression, Anxiety and Stress of Family Caregivers of Patients with Prostate Cancer: A Randomized Clinical Trial
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3207-3212. Epub 2017 Dec 28.
    Department of Nursing, Faculty of Nursing and Midwifery, Ilam University of Medical Science, Ilam, Iran.
    Background: The family caregivers of patients with cancer mightexperience various physical, mental, and spiritual difficulties, the neglect of which can causeseriousproblems for theentirefamily. If caregivers are left without appropriate treatment and intervention, their level of physical and mental health will substantially decrease-they will, in other words, become“hidden patients.” Materials and Methods: The current study is a clinical trial of 80 family caregivers of patients with prostate cancer, who were allocated to control and experimental groups. Read More

    Breast Cancer Risk From Modifiable and Non-Modifiable Risk Factors among Women in Southeast Asia: A Meta-Analysis
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3201-3206. Epub 2017 Dec 28.
    Doctoral Program, Faculty of Medicine, Universitas Gadjah Mada, Indonesia. Email:
    Objective: The aim of this study was to determine breast cancer risk from modifiable and non-modifiable factors among women in Southeast Asia. Methods: This meta-analysis was performed on research articles on breast cancer risk factors in PubMed, ProQuest and EBSCO databases published between 1997 and October 2017. Pooled odds ratios (OR) are calculated using fixed and random-effect models. Read More

    Comparative Diagnostic Performance of Ultrasonography and 99mTc-Sestamibi Scintigraphy for Parathyroid Adenoma in Primary Hyperparathyroidism; Systematic Review and Meta- Analysis
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3195-3200. Epub 2017 Dec 28.
    Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
    Objective: Ultrasonography (US) and parathyroid scintigraphy (PS) with 99mTc-MIBI are common methods for preoperative localization of parathyroid adenomas but there discrepancies exist with regard to diagnostic accuracy. The aim of the study was to compare PS and US for localization of parathyroid adenoma with a systematic review and meta-analysis of the literature. Methods: Pub Med, Scopus (EMbase), Web of Science and the reference lists of all included studies were searched up to 1st January 2016. Read More

    Cancer Screening Awareness and Practice in a Middle Income Country; A Systematic Review from Iran
    Asian Pac J Cancer Prev 2017 12 28;18(12):3187-3194. Epub 2017 Dec 28.
    Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Email:
    Objective: Ageing population and noticeable changes in lifestyle in developing countries like Iran caused an increase in cancer incidence. This requires organized cancer prevention and screening programs in population level, but most importantly community should be aware of these programs and willing to use them. This study explored existing evidence on public awareness and practice, as well as, adherence to cancer screening in Iranian population. Read More

    Impact of Smoking on Health-Related Quality of Life: A General Population Survey in West Iran
    Asian Pac J Cancer Prev 2017 11 26;18(11):3179-3185. Epub 2017 Nov 26.
    Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.Email:
    This study was aimed at assessing any association between smoking and health-related quality of life (HRQoL) among adults aged 18 years and above living in Kermanshah city, western Iran. A cross-sectional study was conducted on a total sample of 1,543 participants obtained by convenient sampling during the period from February 1st to May 30th, 2017. Data were collected using a self-administrated questionnaire. Read More

    Significance of the Cytological Signs of Human Papillomavirus Infection in Anal Pap Smears of Human Immunodeficiency Virus-Infected Japanese Men Who Have Sex with Men
    Asian Pac J Cancer Prev 2017 11 26;18(11):3173-3178. Epub 2017 Nov 26.
    School of Medical Technology, Faculty of Health Science, Gunma Paz University, Japan. Email:
    Purpose: The incidence of invasive anal cancer (IAC) has been increasing among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). Although cytological diagnosis is the modality of choice for screening cases of IAC, it is associated with lower sensitivity and specificity. Therefore, the present study aimed to evaluate new cytological signs of human papillomavirus (HPV) infection that may contribute to improving anal cytology. Read More

    Evaluation of Mir-224, Mir-215 and Mir-143 as Serum Biomarkers for HCV Associated Hepatocellular Carcinoma
    Asian Pac J Cancer Prev 2017 11 26;18(11):3167-3171. Epub 2017 Nov 26.
    Department of Biochemistry and Molecular Biology, Theodor Bilharz Research Institute, Egypt. Email:
    HCV induced hepatitis and hepatocellular carcinoma as its sequel are major health problems world-wide and especially in Egypt. For diagnosis and during treatment of liver diseases, liver functions are monitored through determination of serum levels of liver enzymes and α-fetoprotein although the obtained information is generally not sufficient for either early detection of hepatic insult or effective follow up of therapeutic effects. More sensitive biomarkers may help to achieve these goals. Read More

    Association of Voltage-Gated Sodium Channel Genetic Polymorphisms with Oxaliplatin-Induced Chronic Peripheral Neuropathy in South Indian Cancer Patients
    Asian Pac J Cancer Prev 2017 11 26;18(11):3157-3165. Epub 2017 Nov 26.
    Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Email:
    Oxaliplatin is a platinum drug active against digestive tract cancers. Among its side effects, peripheral neuropathy is one of the dose-limiting toxicities. This affects around 50 to 70% of patients but the pathophysiology of development of oxaliplatin-induced peripheral neuropathy (OXAIPN) remains unclear. Read More

    Oncologists’ Perspectives on Consolidation Radiation Treatment after Chemotherapy for Lymphomas: A Survey Study by the Lymphoma Working Committee of the Turkish Oncology Group (TOG)
    Asian Pac J Cancer Prev 2017 11 26;18(11):3149-3155. Epub 2017 Nov 26.
    Mugla Sitki Kocman University Faculty of Medicine, Department of Medical Oncology, Mugla, Turkey. Email:
    In this study, we aimed to determine the perspectives of medical and radiation oncologists regarding consolidation radiotherapy in patients with a complete response after chemotherapy for Hodgkin’s and non-Hodgkin’s lymphomas. The survey was designed to identify demographic and occupational features of medical and radiation oncologists and their views on application of consolidation radiotherapy in their clinical practices, as based on a five-point Likert scale (never, rarely, sometimes, often, and always). The study covered 263, out of 935, physicians working in the oncology field as either medical or radiation oncologists; the rate of return on the invitations to participate was 28%. Read More

    Detection of Juxtapleural Nodules in Lung Cancer Cases Using an Optimal Critical Point Selection Algorithm
    Asian Pac J Cancer Prev 2017 11 26;18(11):3143-3148. Epub 2017 Nov 26.
    MCA Department, St.Xavier’s College, Tamilnadu,India, Email:
    Detection of lung cancer through image processing is an important tool for diagnosis. In recent years, image processing techniques have become more widely used. Lung segmentation is an essential pre-processing step for most (CAD) schemes. Read More

    The Utilization of Karyotyping, iFISH, and MLPA for the Detection of Recurrence Genetic Aberrations in Multiple Myeloma
    Asian Pac J Cancer Prev 2017 11 26;18(11):3135-3142. Epub 2017 Nov 26.
    Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Email:
    Multiple myeloma (MM) is a hematological malignancy characterized by abnormal accumulation of clonal plasma cells in the bone marrow. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged as an effective and robust method for detection of common genetic alterations in MM patients. Here, we aimed to confirm MLPA utility for this purpose and furthermore to test the feasibility of a combination of karyotyping, interphase fluorescence in situ hybridization (iFISH) and MLPA methods for diagnosis, prognostic assessment and risk stratification of MM. Read More

    Multi-Gene Expression in Anthracosis of the Lungs as One of the Risk Factors for Non-Small Cell Lung Cancer
    Asian Pac J Cancer Prev 2017 11 26;18(11):3129-3133. Epub 2017 Nov 26.
    Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:
    Background: Anthracosis of the lung occurs due to the deposition of carbon and silica in the mucosa and submucosa, manifested as black lesions. The association of anthracosis with lung cancer has remained to be clearly elucidated The current study aimed to assess the P16, CDH1 and LUNX genes expression level to evaluate the association of anthracotic lesions in the lungs with the occurrence of non-small cell lung cancer. Methods: Forty biopsy samples were taken from the center and 40 from the margins of black anthracotic lesions in the lungs; RNA was extracted from the samples and cDNA was synthesized. Read More

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