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    9089 results match your criteria Asian Pacific journal of cancer prevention : APJCP[Journal]

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    Retracted: Silencing of the COPS3 Gene by siRNA Reduces Proliferation of Lung Cancer Cells Most Likely via Induction of Cell Cycle Arrest and Apoptosis
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    Asian Pac J Cancer Prev 2017 11 17;18(10):2893-2893. Epub 2017 Nov 17.
    Retraction: Retracted: siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells Asian Pacific Journal of Cancer Prevention has retracted the article titled “siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells”(1) for reason of similarity with a series of articles identified by Byrne and Labbé (2). 1. Huang WY1, Chen DH, Ning L, Wang LW. Read More

    Retracted: siRNA Mediated Silencing of NIN1/RPN12 Binding Protein 1 Homolog Inhibits Proliferation and Growth of Breast Cancer Cells
    Asian Pac J Cancer Prev 2017 10 27;18(10):2891-2891. Epub 2017 Oct 27.
    Retraction: Retracted: siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells Asian Pacific Journal of Cancer Prevention has retracted the article titled “siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells”(1) for reason of similarity with a series of articles identified by Byrne and Labbé (2). 1. Huang WY1, Chen DH, Ning L, Wang LW. Read More

    Preliminary Results: Colorectal Cancer Screening Using Fecal Immunochemical Test (FIT) in a Thai Population Aged 45-74 Years: A Population-Based Randomized Controlled Trial
    Asian Pac J Cancer Prev 2017 10 26;18(10):2883-2889. Epub 2017 Oct 26.
    Epidemiology and Biostatistics Department, Faculty of Public Health, Khon Kaen University, Thailand.
    Objective: The aim of this paper is to provide some details and the results to date of a colorectal cancer screening trial using a fecal immunochemical test (FIT). Methods: A population-based randomized controlled trial began in May, 2016. All people aged 45 to 74 years living in Nam Phong District, Khon Kaen Province, Thailand, and willing to participate are being recruited using an outreach method. Read More

    Actual Daily Intakes of Tea Catechins and Thier Estimation According to Four Season 3 Day Weighed Dietary Records and a Short Food Frequency Questionnaire among Japanese Men and Women
    Asian Pac J Cancer Prev 2017 10 26;18(10):2875-2881. Epub 2017 Oct 26.
    Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.Email:
    Background: Tea catechins are considered to be important preventive factors of cancer on several organs; however, the relationships of the actual daily intakes (ADIs) on the preventive effects have not been adequately addressed. We measured the ADIs of tea catechins as annual averages derived from every their ingested cups recorded by each subject, and the estimation models were established considering tea origin. Methods: Fifty-nine Japanese men and women completed four season 3 day weighed dietary records (WDRs) and a food frequency questionnaire (FFQ), and samples of green, oolong and black teas, ingested during a total 12 days were collected for the analysis. Read More

    Economic Burden of Smoking in Iran: A Prevalence-Based Annual Cost Approach
    Asian Pac J Cancer Prev 2017 10 26;18(10):2867-2873. Epub 2017 Oct 26.
    Research Center for Environmental Determinants of Health, Kermanshah University of Medical sciences, Kermanshah, Iran. Email:
    Objectives: The burden of smoking on the health system and society is significant. The current study aimed to estimate the annual direct and indirect costs of smoking in Iran for the year 2014. Methods: A prevalence-based diseasespecific approach was used to determine costs associated with the three most common smoking-related diseases: lung cancer (LC), chronic obstructive pulmonary disease (COPD) and ischaemic heart disease (IHD). Read More

    From Love and Fidelity to Infidelity- Individual Experiences of Women with Breast Cancer Regarding Relationships with Their Spouses
    Asian Pac J Cancer Prev 2017 10 26;18(10):2861-2866. Epub 2017 Oct 26.
    Department of Nursing, Faculty of Nursing and Midwifery, Zabol University of Medical Sciences, Zabol, Iran. Email:
    Background and Objective: Breast cancer and its treatment processes not only involve the patients but also their spouses and can impact on mutual relationships. Spouses of women with breast cancer may experience devastating consequences of the disease in their marital and sexual relationships. Therefore, in the present study we aimed to investigate individual experiences of women with breast cancer in their relationships with their spouses. Read More

    A Large Scale Study of the Epidemiology and Risk Factors for the Carcinogenic Liver Fluke Opisthorchis viverrini in Udon Thani Province, Thailand
    Asian Pac J Cancer Prev 2017 10 26;18(10):2853-2860. Epub 2017 Oct 26.
    Department of Biology, Faculty of Science, Udon Thani Rajabhat University, Udon Thani, Thailand
    Opisthorchis viverrini infection and cholangiocarcinoma are serious problems in South East Asia. This study aimed to find the prevalence of opisthorchiasis in various hosts in Udon Thani Province. Total fecal samples were collected from 14,766 participants. Read More

    Inhibition of Topoisomerase IIα and Induction of Apoptosis in Gastric Cancer Cells by 19-Triisopropyl Andrographolide
    Asian Pac J Cancer Prev 2017 10 26;18(10):2845-2851. Epub 2017 Oct 26.
    Toxicology Graduate Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand. Email:
    Gastric cancer is the most common cancer in Eastern Asia. Increasing chemoresistance and general systemic toxicities have complicated the current chemotherapy leading to an urgent need of more effective agents. The present study reported a potent DNA topoisomerase IIα inhibitory activity of an andrographolide analogue (19-triisopropyl andrographolide, analogue-6) in gastric cancer cells; MKN-45, and AGS cells. Read More

    Effectiveness of 7-Day and 14-Day Moxifloxacin-Dexlansoprazole Based Triple Therapy and Probiotic Supplement for Helicobacter Pylori Eradication in Thai Patients with Non-Ulcer Dyspepsia: A Double-Blind Randomized Placebo-Controlled Study
    Asian Pac J Cancer Prev 2017 10 26;18(10):2839-2843. Epub 2017 Oct 26.
    Gastroenterology Unit, Thammasat University Hospital, Pathumthani,, Thailand.
    Background: Helicobacter pylori (H. pylori) is important cause of peptic ulcer and gastric cancer. Moxifloxacin is effective antibiotic for treatment for H. Read More

    Educational Intervention on Breast Self-Examination Behavior in Women Referred to Health Centers: Application of Health Belief Model
    Asian Pac J Cancer Prev 2017 10 26;18(10):2833-2838. Epub 2017 Oct 26.
    Department of Public Health, School of Health, Fasa University of Medical Sciences, Fasa, Iran. Email:
    Introduction and aims: Screening can play a major role in reducing deaths associated with cancer. Breast selfexamination (BSE) is a cheap, non-complicated and non-invasive method for breast cancer screening. This study aimed to examine the effects of an educational intervention based on the health belief model (HBM) on BSE behavior in women referred to health centers in Fasa, Iran. Read More

    Long-Term Disease-Free Survival of Non-Metastatic Breast Cancer Patients in Iran: A Survival Model with Competing Risks Taking Cure Fraction and Frailty into Account
    Asian Pac J Cancer Prev 2017 10 26;18(10):2825-2832. Epub 2017 Oct 26.
    Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Email:
    Introduction: Survival modeling is a very important tool to detect risk factors and provide a basis for health care planning. However, cancer data may have properties leading to distorted results with routine methods. Therefore, this study aimed to cover specific factors (competing risk, cure fraction and heterogeneity) with a real dataset of Iranian breast cancer patients using a competing risk-cure-frailty model. Read More

    Prognostic Factors of Adrenocortical Carcinoma: An Analysis of the Surveillance Epidemiology and End Results (SEER) Database
    Asian Pac J Cancer Prev 2017 10 26;18(10):2817-2823. Epub 2017 Oct 26.
    Department of Urology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China. Email:
    Objective: To define the prognostic factors associated with overall survival (OS) and cancer-specific survival (CSS) for adrenocortical carcinoma (ACC). Patients and Methods: We used the Surveillance, Epidemiology and End Results (SEER) database (1973-2014) to identify ACC patients. Correlated variables, including age, sex, race, tumor laterality, marital status at diagnosis, treatment of primary site, lymph node dissection, radiation therapy, chemotherapy, tumor size and tumor stage, were extracted. Read More

    Anxiety, Depression and Quality of Life in Breast Cancer Patients in the Levant
    Asian Pac J Cancer Prev 2017 10 26;18(10):2809-2816. Epub 2017 Oct 26.
    Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Email:
    Background: Limited data are currently available regarding the psychological well-being and quality of life of breast cancer patients after active treatment in Lebanon and the Arab region in general. The objective of this study was to determine the prevalence of anxiety and depression among Arab breast cancer patients and assess the quality of life with reference to socio-demographic and clinical characteristics. Methods: This cross-sectional study was conducted among female breast cancer patients diagnosed between January 2009 and March 2014, who were recruited from the outpatient clinics of Naef K. Read More

    Prediction of Response to Irinotecan and Drug Toxicity Based on Pharmacogenomics Test: A Prospective Case Study in Advanced Colorectal Cancer
    Asian Pac J Cancer Prev 2017 10 26;18(10):2803-2807. Epub 2017 Oct 26.
    Hematology-Medical Oncology Department Cancer Research Center, Cancer Institute of Iran, Tehran University Medical Sciences, Tehran, Iran. Email:
    Background: FOLFIRI regimen, which is composed of 5-FU, Leucovorin, and Irinotecan, is used in the first-line chemotherapy of metastatic colorectal cancer. Irinotecan life threatening toxicity is partly related to cytotoxic drug metabolite which is primarily inactivated by the UGT1A1 enzyme. The primary aim of the present research was to find the correlation between UGT1A1-genotype and clinical toxicity of irinotecan. Read More

    Novel IRF-1 Mutations in a Small Cohort of Leukaemia Patients From Saudi Arabia
    Asian Pac J Cancer Prev 2017 10 26;18(10):2795-2801. Epub 2017 Oct 26.
    Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Dammam, Dammam, Saudi Arabia. Email:
    Involvement of the Interferon Regulatory Factor 1 (IRF-1) gene in regulation of cell differentiation and proliferation made it a potential target in cancer research. IRF-1 acts as a tumor suppressor gene, and is inactivated in chronic (CML) and non-chronic myelogenous leukemia (non-CML). In the light of numerous reports on genetic changes in the noncoding region of the IRF-1 gene, this study aimed to explore possible genomic changes in coding and non-coding regions of IRF-1 in a random sample of leukemic Saudi patients, in order to obtain insights into potential impact of genetic changes on clinicopathological characteristics. Read More

    Impact of a Stress Management Intervention Program on Sexual Functioning and Stress Reduction in Women with Breast Cancer
    Asian Pac J Cancer Prev 2017 10 26;18(10):2787-2793. Epub 2017 Oct 26.
    Instructor of Midwifery, Mother and child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Email:
    Breast cancer as the most common cancer among women endangers various aspects of their sexual lives and is a major culprit regarding health impairment and low life quality. The aim of this study was to examine the effect of a stress management intervention program on sexual functioning and stress reduction in women with breast cancer. This study employed a quasi-experimental pre-test, post-test design which included follow-up checks and a control group. Read More

    p16 Tumor Suppressor Gene Methylation in Diffuse Large B Cell Lymphoma: A Study of 88 Cases at Two Hospitals in the East Coast of Malaysia
    Asian Pac J Cancer Prev 2017 10 26;18(10):2781-2785. Epub 2017 Oct 26.
    Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malysia. Email:
    Introduction: p16 gene plays an important role in the normal cell cycle regulation. Methylation of p16 has been reported to be one of the epigenetic events contributing to the pathogenesis of diffuse large B-cell lymphoma (DLBCL) which occurring at varying frequency. DLBCL is an aggressive and high-grade malignancy which accounts for approximately 30% of all non-Hodgkin lymphoma cases. Read More

    Survey of Cancer Patient Safety Culture: A Comparison of Chemotherapy and Oncology Departments of Teaching Hospitals of Tehran
    Asian Pac J Cancer Prev 2017 10 26;18(10):2775-2779. Epub 2017 Oct 26.
    Department of Health Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. Email:
    Background: Patient safety culture plays an important role in healthcare systems, especially in chemotherapy and oncology departments (CODs), and its assessment can help to improve quality of services and hospital care. Objective: This study aimed to evaluate and compare items and dimensions of patient safety culture in the CODs of selected teaching hospitals of Iran and Tehran University of Medical Sciences. Materials and Methods: This descriptive-analytical crosssectional survey was conducted during a six-month period on 270 people from chemotherapy and oncology departments selected through a cluster sampling method. Read More

    Knowledge Attitude and Practice of Colorectal Cancer among School Teachers in Al-Ahsa Saudi Arabia
    Asian Pac J Cancer Prev 2017 10 26;18(10):2771-2774. Epub 2017 Oct 26.
    Medical intern, King Faisal University, college of medicine, Al-Ahsa Saudi Arabia. Email:
    Background: Colorectal cancer is the second leading cause of deaths among cancers affecting both men and women in the United States. Annually, about 140,000 Americans are diagnosed with colorectal cancer, and more than 50,000 people die from it. In Saudi Arabia, this cancer ranks first among men and third among women. Read More

    Factors Associated with a Lack of Knowledge of Performing Breast Self-Examination and Unawareness of Cervical Cancer Screening Services: Evidence from the 2015 Egypt Health Issues Survey
    Asian Pac J Cancer Prev 2017 10 26;18(10):2763-2769. Epub 2017 Oct 26.
    Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al–Ain, United Arab Emirates. Email:
    Background: The incidence of breast and cervical cancers is growing rapidly among Egyptian women. In this context, we assessed the prevalence of, and factors associated with the lack of knowledge among Egyptian females of performing breast self–examination (BSE) and unawareness of cervical smear cancer screening services. Methods: Secondary data analysis was performed on a representative population-based sample of 7,518 Egyptian females aged 15–59 years from the 2015 Egypt Health Issues Survey (EHIS). Read More

    Knowledge and Perceptions of Common Breast Cancer Risk Factors in Northern Saudi Arabia
    Asian Pac J Cancer Prev 2017 10 26;18(10):2755-2761. Epub 2017 Oct 26.
    College of Medicine, University of Hail, Saudi Arabia. Email:
    Background: Breast cancer is the second leading cause of cancer death in women around the world. The degree of adoption of a preventive lifestyle offers valuable information for planning appropriate intervention programs for improving women’s health. The objective of the present study was to assess the levels of breast cancer related knowledge among a Northern Saudi population. Read More

    Inconsistencies of Breast Cancer Risk Factors between the Northern and Southern Regions of Vietnam
    Asian Pac J Cancer Prev 2017 10 26;18(10):2747-2754. Epub 2017 Oct 26.
    Faculty of Health Sciences, The University of Sydney, 75 East street, Lidcombe, New South Wales, Australia.
    Background: In recent decades the amount of new breast cancer cases in the southern region has been reported to increase more rapidly than in the northernVietnam. The aim of this study is to compare breast cancer risk factors between the two regions and establish if westernized influences have an impact on any reported differences. Method: Data was collected from the two largest oncology hospitals in the north and the south of Vietnam in 2015. Read More

    Outcomes of High Risk Patients with Febrile Neutropenia at a Tertiary Care Center
    Asian Pac J Cancer Prev 2017 10 26;18(10):2741-2745. Epub 2017 Oct 26.
    Department of Oncology, Aga Khan University Hospital, Karachi, Pakistan. Email:
    Fever during chemotherapy-induced neutropenia continues to be a major cause of morbidity and mortality in cancer patients. Mortality depends on the duration and degree of neutropenia, bacteremia, sepsis, performance status, comorbidities and other parameters. The highest mortality rates in cancer patients hospitalized with febrile neutropenia (FN) are observed in those with documented infection. Read More

    Colorectal Cancer Incidence Trend and Projections in Tunisia (1994 - 2024)
    Asian Pac J Cancer Prev 2017 10 26;18(10):2733-2739. Epub 2017 Oct 26.
    Department of Epidemiology, Salah Azaiez Institute of Tunis, Tunisia. Email:
    Objectives: The aim of this study was to describe trends of colorectal cancer incidence during the period 1994-2009 and to generate projections until 2024. Methods: The North-Tunisia Cancer Registry (NTCR) was the source of data for patients with CRC. This registry lists, since 1994, cases of malignant tumors in people living in North Tunisia, including the District of Tunis, the north east and the north west. Read More

    Free Radical Scavenging Properties of Annona squamosa
    Asian Pac J Cancer Prev 2017 10 26;18(10):2725-2731. Epub 2017 Oct 26.
    Division of Cancer Research, Regional Cancer Centre, Trivandrum, India. Email:
    Annona squamosa has extensively been used in the traditional and folkloric medicine and found to possess many biological activities. Different solvents, petroleum ether, chloroform, ethyl acetate and methanol extracts of Annona squamosa seeds (ASPE, ASCH, ASEA, ASME) have been used to prepare plant extracts. The present investigations dealt with the free radical scavenging activity of four extracts using various techniques such as total reducing power estimation, total phenolic count, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging effect, evaluation of ABTS cation decolorisation capacity, FRAP assay, hdroxyl radical scavenging assay, super oxide assay and Nitric oxide radical scavenging assay of the extracts. Read More

    The DNA Methyltransferase 3B -149 Genetic Polymorphism Modulates Lung Cancer Risk from Smoking
    Asian Pac J Cancer Prev 2017 10 26;18(10):2717-2723. Epub 2017 Oct 26.
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.|
    Background: Smoking can cause increase of DNA methylation and hypermethylation of tumor suppressor genes, this possible contributing to subsequent lung cancer development. DNA methyltransferase 3B (DNMT3B) is crucial in regulation of DNA methylation and it has been proposed that green tea might lower cancer risk through inhibiting its activity. Here, we designed a case-control study to investigate whether the DNMT3B -149 genetic polymorphism could modulate lung cancer risk due to smoking. Read More

    Bayesian Inference on Malignant Breast Cancer in Nigeria: A Diagnosis of MCMC Convergence
    Asian Pac J Cancer Prev 2017 10 26;18(10):2709-2716. Epub 2017 Oct 26.
    Statistics Department, University of Kwa Zulu Natal, Westville Campus, Durban, South Africa. Email: 215082165@
    Background: There has been no previous study to classify malignant breast tumor in details based on Markov Chain Monte Carlo (MCMC) convergence in Western, Nigeria. This study therefore aims to profile patients living with benign and malignant breast tumor in two different hospitals among women of Western Nigeria, with a focus on prognostic factors and MCMC convergence. Materials and Methods: A hospital-based record was used to identify prognostic factors for malignant breast cancer among women of Western Nigeria. Read More

    Pegfilgrastim Versus Filgrastim for Primary Prophylaxis of Febrile Neutropenia in Patients with non-Hodgkin’s Lymphoma: A Cost-Effectiveness Study
    Asian Pac J Cancer Prev 2017 10 26;18(10):2703-2707. Epub 2017 Oct 26.
    Department of Health Services Management, School of Management and Medical Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
    Aim: One method to deal with febrile neutropenia is the use of granulocyte colony stimulating factors (G-CSFs). Pegfilgrastim or Filgrastim injection can lead to a reduction in febrile neutropenia and severe neutropenia in patients receiving chemotherapy. This study aimed to compare the cost-effectiveness of using Pegfilgrastim, 3-day Filgrastim and 1-day Filgrastim medication strategies for the primary prophylaxis of febrile neutropenia in patients with relapsed non-Hodgkin’s lymphoma after salvage chemotherapy who referred to two referral centers affiliated to Iran, Shiraz University of Medical Sciences in 2014. Read More

    Evaluation on Efficacy and Safety of Arsenic Trioxide Plus Transcatheter Arterial Chemoembolization Versus Transcatheter Arterial Chemoembolization alone for Unresectable Primary Liver Cancer
    Asian Pac J Cancer Prev 2017 10 26;18(10):2695-2701. Epub 2017 Oct 26.
    Department of Chemotherapy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, P.R.China. Email:
    Currently, some clinical trials of arsenic trioxide (As203) plus transcatheter arterial chemoembolization (TACE) in the treatment of unresectable primary liver cancer (PLC) had been conducted, but the results were controversial. Therefore, we performed a meta-analysis on 14 clinical trials (1076 cases) to evaluate efficacy and safety of As203 plus TACE versus TACE alone for unresectable PLC. The primary end points included objective response rate (ORR), karnofsky performance score (KPS) improvement rate, and 1-year survival rate. Read More

    Tumor-Associated Neutrophils in Breast Cancer Subtypes
    Asian Pac J Cancer Prev 2017 10 26;18(10):2689-2693. Epub 2017 Oct 26.
    Cancer Care in the Elderly Clinic, Department of Geriatrics. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico. Email:
    Background: Tumor associated neutrophils (TAN) are related to aggressiveness and a poor prognosis with human cancers. However, the relevance of TAN in breast cancer has not been previously investigated and here we sought to determine their presence among different subtypes. Methods: We analyzed patients with stage I-III breast cancers between 2006 and 2012. Read More

    Genetic Polymorphisms of Fas/FasL Promoter Associated with Hepatitis C cirrhosis and HCC
    Asian Pac J Cancer Prev 2017 10 26;18(10):2683-2688. Epub 2017 Oct 26.
    Department of Tropical Medicine, Faculty of Medicine, Mansoura University, Egypt. Email:
    Aim: The present study was performed to determine any associations of genetic polymorphisms of Fas/FasL promoter regions, at Fas670 and Fas1377 and FasL844, with hepatitis C cirrhosis and HCC, with a focus on severity of disease. Methods: Totals of 120 patients with cirrhosis and 101 with hepatocellular carcinoma (HCC) were enrolled. All had chronic HCV infection as indicated by positive anti-HCV antibodies and positive HCV RNA on real time PCR. Read More

    Analysis of ARID2 Gene Mutation in Oral Squamous Cell Carcinoma
    Asian Pac J Cancer Prev 2017 10 26;18(10):2679-2681. Epub 2017 Oct 26.
    Department of Oral Medicine and Radiology, SRM Dental College, Ramapuram, Chennai, India.Email:
    Background: The ARID2 gene, encoding a sub unit of the chromatin remodelling complex, has a possible tumour suppressor function and has been found to be frequently mutated in various tumours, including gingivo buccal oral squamous cell carcinomas. The present study was designed to analyse the presence of ARID2 gene mutations in the distinct genetic South Indian (Dravidian) population. Materials and Methods: Genomic DNA from thirty biopsy tissue samples of histopathologically confirmed cases of oral squamous cell carcinoma (OSCC) were subjected to PCR amplification with intronic primers encompassing exons 19 and 20 of ARID2. Read More

    Impact of Her-2 Overexpression on Survival of Patients with Metastatic Breast Cancer
    Asian Pac J Cancer Prev 2017 10 26;18(10):2673-2678. Epub 2017 Oct 26.
    Pathology Research Laboratory, Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil. Email:
    Introduction: Breast cancer is a complex and heterogeneous disease which is increasingly important as a public health problem. In Brazil, 57,960 new cases have been estimated to be the burden in 2016 and 2017. Despite advances in early diagnosis and therapy, approximately 20-30% of patients, even with early stage lesions, will develop distant metastatic disease. Read More

    Stage Association of Preoperative Serum Carcinoembryonic Antigen with Gastric Adenocarcinoma in Iranian Patients
    Asian Pac J Cancer Prev 2017 10 26;18(10):2669-2672. Epub 2017 Oct 26.
    GI Cancer Screening and Prevention Research Center(GCSPRC), Guilan University of Medical Sciences), Rasht, Iran. Email:
    Background: Gastric cancer is the second leading cause of cancer-related mortality and the fourth most common cancer globally. Tumor markers are needed for appropriate management and monitoring of treatment to improve quality of life. Recently, carcinoembryonic antigen (CEA) has been widely used as a tumor marker in the diagnosis and follow-up of some malignancies. Read More

    Breast Cancer Screening Disparity among Korean American Immigrant Women in Midwest
    Asian Pac J Cancer Prev 2017 10 26;18(10):2663-2667. Epub 2017 Oct 26.
    School of Social Work University of Minnesota, Twin Cities, MN. United States. Email:
    Purpose: Using three breast cancer screening methods such as mammogram, Clinical Breast Examination (CBE), and Breast Self-Examination (BSE), this study investigated breast cancer screening rates and its associated factors in Korean American immigrant women. Method: Cross-sectional data were obtained from 168 Korean immigrant women aged 40 and older in Midwest. The Andersen’s Behavioral Model (1995) theoretically guided this study and logistic regression was used to examine factors associated with screening receipt and performance. Read More

    Risk Factors for Hydatidiform Mole: Is Husband’s Job a Major Risk Factor?
    Asian Pac J Cancer Prev 2017 10 26;18(10):2657-2662. Epub 2017 Oct 26.
    Infertility and Reproductive Health Research Centre (IRHRC) , Shahid Beheshti University of Medical Sciences, Tehran, Iran .
    Background: The hydatidiform mole (HM) is a precancerous placenta considered as a gestational trophoblastic disease (GTD). It may convert to more invasive forms of gestational trophoblastic neoplasia (GTN), endangering women’s health by more severe complications. Most GTN cases originate from HM, which is associated with uterine bleeding, preeclampsia and thyroid problems. Read More

    Body Misperception and Its Associated Factors among Cancer Survivors in Korea
    Asian Pac J Cancer Prev 2017 10 26;18(10):2649-2656. Epub 2017 Oct 26.
    Department of Family Medicine, Myongji Hospital, Seonam University, College of Medicine, Gyeonggi-do, Republic of Korea. Email:
    Background: As the number of cancer survivors is increasing, the importance of their healthcare management is becoming emphasized. For this purpose, appropriate recognition of the importance of body weight is necessary. This study concerned misconceptions about body weight and related factors among cancer patients. Read More

    p16INK4a Expression in Cervical Lesions Correlates with Histologic Grading - a Tertiary Level Medical Facility Based Retrospective Study
    Asian Pac J Cancer Prev 2017 10 26;18(10):2643-2647. Epub 2017 Oct 26.
    Pathology Department, Tezpur Medical College, Tezpur, India. Email:
    p16INK4a is a tumor-suppressor protein and cyclin-dependent kinase (cdk) inhibitor that blocks cdk4- and cdk6-mediated pRb phosphorylation to inhibit E2F-dependent transcription and cell-cycle progression. Because the E7 protein of high-risk HPVs inactivates pRB, the resulting overexpression of p16INK4a may be a good marker for infection with high risk HPV types. Immunostaining of p16INK4a allows precise identification of even small CIN or cervical cancer lesions in biopsy sections and can help reduce inter-observer variation in the histopathological interpretation of cervical biopsy specimens. Read More

    Nepalese Helicobacter pylori Genotypes Reflects a Geographical Diversity than a True Virulence Factor
    Asian Pac J Cancer Prev 2017 10 26;18(10):2637-2641. Epub 2017 Oct 26.
    Civil service hospital, Minbhawan, Kathmandu, Nepal. Email:
    Background: The data about the association between Helicobacter pylori putative virulence factors; iceA and jhp0562/β-(1,3)galT with clinical outcomes are still controversial. We identified and analyzed two putative H. pylori virulence factors in Nepalese strains. Read More

    A Systems Biology Approach Provides Deeper Insights into Differentially Expressed Genes in Taxane-Anthracycline Chemoresistant and Non-Resistant Breast Cancers
    Asian Pac J Cancer Prev 2017 10 26;18(10):2629-2636. Epub 2017 Oct 26.
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Email:
    Objective: To date, numerous studies have been conducted to search for reasons for chemoresistance and differences in survival rates of patients receiving chemotherapy. We have sought to identify differentially expressed genes (DEGs) between predicted chemotherapy resistance and sensitive phenotypes by a network as well as gene enrichment approach. Methods: Functional modules were explored with network analysis of DEGs in predicted neoadjuvant taxane-anthracycline resistance versus sensitive cases in the GSE25066 dataset, including 508 samples. Read More

    Diagnostic Challenges in Prostate Cancer and 68Ga-PSMA PET Imaging: A Game Changer?
    Asian Pac J Cancer Prev 2017 10 26;18(10):2625-2628. Epub 2017 Oct 26.
    Section of Nuclear Medicine and PET/CT Imaging, Department of Radiology, Aga Khan University Hospital (AKUH), Karachi Pakistan .Email:
    Prostate cancer (PC) is the most frequent solid tumor in men and the third most common cause of cancer mortality among men in developed countries. Current imaging modalities like ultrasound (US), computerized tomography (CT), magnetic resonance imaging (MRI) and choline based positron emission (PET) tracing have disappointing sensitivity for detection of nodal metastasis and small tumor recurrence. This poses a diagnostic challenge in staging of intermediate to high risk PC and restaging of patients with biochemical recurrence (PSA >0. Read More

    An Overview of Asbestos and Malignant Pleural Mesothelioma: An Iranian Perspective
    Asian Pac J Cancer Prev 2017 10 26;18(10):2619-2623. Epub 2017 Oct 26.
    National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences,Tehran, Iran. Email:
    Asbestos refers to a group of minerals that appears naturally in the environment as bundles of fibers. The incidence rate of asbestos-related diseases has considerably increased as well as the amount of asbestos utilization in few countries. Malignant pleural mesothelioma (MPM) is a rare type of aggressive and life threatening neoplasm which arise from various serous surfaces: pleura, peritoneum, tunica vaginalis and pericardium. Read More

    Association between Polymorphisms of ERCC5 Gene and Susceptibility to Gastric Cancer: A Systematic Review and Meta-Analysis
    Asian Pac J Cancer Prev 2017 10 26;18(10):2611-2617. Epub 2017 Oct 26.
    Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
    Background: several epidemiological studies have suggested that polymorphisms of the Excision Repair Cross Complementing Group-5 (ERCC5) gene might be related to gastric cancer risk; however, the results have been inconsistent or controversial. Therefore, we have performed a systematic review and meta-analysis to clarify the association between the ERCC5 gene polymorphisms and gastric cancer risk. Materials and Methods: An electronic search was conducted of several databases, including PubMed, Web of Science, and Google Scholar for articles that describe the association between polymorphisms of the ERCC5 gene and susceptibility of gastric cancer. Read More

    Long Non Coding RNA Expression Intersecting Cancer and Spermatogenesis: A Systematic Review
    Asian Pac J Cancer Prev 2017 10 26;18(10):2601-2610. Epub 2017 Oct 26.
    Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical sciences, Tehran, Iran. Email:
    Background: Numerous similarities have been noted between gametogenic and tumorigenic programs in features such as global hypomethylation, immune evasion, immortalization, meiosis induction, and migration. In addition, aberrant expression of testis specific genes has been detected in various cancers which has led to categorization of these genes as “cancer-testis genes”. Most of the examples identified in this category are protein encoding. Read More

    OPN b and c Isoforms Doubtless Veto Anti-angiogenesis Effects of Curcumin in Combination with Conventional AML Regiment
    Asian Pac J Cancer Prev 2017 09 27;18(9):2591-2599. Epub 2017 Sep 27.
    Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. Email:
    Osteopontin (OPN) is an extracellular structural protein that is secreted by osteoblasts and hematopoietic cells. It suppresses the proliferation of hematopoietic stem and also plays an important role in promoting survival and drug resistance in leukemic stem cells (LSCs). Since the role of OPN isoforms in AML angiogenesis are remaining controversial, in the present study, we aimed to evaluate whether curcumin (CUR), as a known natural component with anti-angiogenesis effects, in a combination of AML conventional regiment has the potency to preclude induced anti-angiogenesis effects of OPN isoforms or not? Leukemia cells were treated with different concentration of CUR and AML conventional drugs alone and/or in combination with together to find effective doses and IC50 values. Read More

    Generalized Linear Mixed Model Analysis of Urban-Rural Differences in Social and Behavioral Factors for Colorectal Cancer Screening
    Asian Pac J Cancer Prev 2017 09 27;18(9):2581-2589. Epub 2017 Sep 27.
    Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN 37614, USA. Email:
    Objective: Screening for colorectal cancer (CRC) can reduce disease incidence, morbidity, and mortality. However, few studies have investigated the urban-rural differences in social and behavioral factors influencing CRC screening. The objective of the study was to investigate the potential factors across urban-rural groups on the usage of CRC screening. Read More

    Human Papillomavirus Investigation in Head and Neck Squamous Cell Carcinoma: Initial Report from the Low Risk HPV Types Associations
    Asian Pac J Cancer Prev 2017 09 27;18(9):2573-2579. Epub 2017 Sep 27.
    Department of Virology, Iran University of Medical Sciences, Tehran, Iran. Email:
    Background: Head and neck squamous cell carcinomas (HNSCC) are a major health issue in many parts of the world. Recently, attention has focused on the human papilloma virus (HPV) as a potential causative agent for HNSCC. This study aimed to survey HPV occurrence in HNSCCs as part of a comprehensive molecular epidemiology approach. Read More

    Risk Factors for Incomplete Excision after Loop Electrosurgical Excision Procedure (LEEP) in Abnormal Cervical Cytology
    Asian Pac J Cancer Prev 2017 09 27;18(9):2569-2572. Epub 2017 Sep 27.
    Department of Obstetrics and Gynecology, Prapokklao Hospital, Chanthaburi, Thailand. Email:
    Objective: To investigate the risk factors related to incomplete excision after loop electrosurgical excision procedure (LEEP) in abnormal cervical cytology. Methods: This retrospective cohort study was performed during September 2010 to February 2017. The study population was patients with abnormal cervical cytology who treated by LEEP at Prapokklao hospital, Chanthaburi. Read More

    Distribution and Role of N-acetyltransferase 2 Genetic Polymorphisms in Bladder Cancer Risk in a Lebanese Population
    Asian Pac J Cancer Prev 2017 09 27;18(9):2561-2568. Epub 2017 Sep 27.
    Division of Urology, Department of Surgery, American University of Beirut Faculty of Medicine, Beirut, Lebanon. Email:
    Background: In Lebanon, bladder cancer (BC) has an unusually high prevalence. Individuals who are exposed to aromatic amines from smoking or certain occupations and carrying the slow N-acetyl transferase 2 (NAT2) acetylator’ phenotype may be at a higher risk. Methods: Data and DNA from 115 Lebanese BC cases and 306 controls were examined. Read More

    The Prognostic Factors of Biochemical Recurrence-Free Survival Following Radical Prostatectomy
    Asian Pac J Cancer Prev 2017 09 27;18(9):2555-2559. Epub 2017 Sep 27.
    Division of Urology, Department of Surgery, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkla University, Songkhla, Thailand. Email:
    Objective: To evaluate outcomes, biochemical recurrence-free survival (BCRFS) and to identify parameters influencing BCRFS of radical prostatectomy (RP) and bilateral pelvic lymph node dissection in a single-institution. Methods: A retrospective review of prostate cancer (PC) patients received RP was identified from the medical records. Data was collected from 2007 to 2016. Read More

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