9,753 results match your criteria Asian Pacific journal of cancer prevention : APJCP[Journal]


EGFR inhibitor C225 Increases the Radio-Sensitivity of Human Breast Cancer Cells

Asian Pac J Cancer Prev 2019 Jan 25;20(1):311-319. Epub 2019 Jan 25.

Department of Oncology, The Third Clinical Medical School of Nanjing Medical University, Nanjing First Hospital of Nanjing Medical University,Nanjing, Jiangsu Province, China.

Objective: This study was undertaken to investigate the effect of C225 on the radio-sensitivity of MDA-MB-231 cells line and to disclosure underlying mechanism. Methods: CCK8 assay was used to measure the proliferation inhibition of C225 on MDA-MB-231 cells. The combined effects of C225 plus radiation on the proliferation of MDA-MB-231 cells were also evaluated by CCK-8 assay. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.311DOI Listing
January 2019
1 Read

Anticancer Effect of Cisplatin-Loaded Poly (Butylcyanoacrylate) Nanoparticles on A172 Brain Cancer Cells Line

Asian Pac J Cancer Prev 2019 Jan 25;20(1):303-309. Epub 2019 Jan 25.

Department of Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.Email:

Background: Drug delivery systems have been designed to achieve targeted delivery and control the release rate of the drugs. A serious challenge associated with drug delivery systems is the presence of the blood-brain barrier which limits drugs penetration. In the current study, the effects of cisplatin nanoparticles on A172 brain cancer cell line were investigated. Read More

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http://journal.waocp.org/article_80262.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.303DOI Listing
January 2019
10 Reads

Efficacy and Safety of Microwave Ablation (MWA) for Hepatocellular Carcinoma (HCC) in Difficult Anatomical Sites in Egyptian Patients with Liver Cirrhosis

Asian Pac J Cancer Prev 2019 Jan 25;20(1):295-301. Epub 2019 Jan 25.

Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt. Email:

Background and aim: Imaging guided microwave ablation (MWA) for hepatocellular carcinoma (HCC) has become a widely used method over recent years. Tumors close to the diaphragm, gastrointestinal tract, gallbladder, pancreas, hepatic hilum and major bile duct or vessels are generally considered relative contraindications for microwave ablation. This study was conducted to assess the effectiveness and safety of ultrasonography-guided MWA in treating patients with HCC in difficult anatomical sites in comparison to those in conventional sites. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.295DOI Listing
January 2019
1 Read

Tumor Protein p53 and K-ras Gene Mutations in Peruvian Patients with Gallbladder Cancer

Asian Pac J Cancer Prev 2019 Jan 25;20(1):289-294. Epub 2019 Jan 25.

Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru. Email:

Background: Recent studies have shown that genetic alterations are associated with the effect of patient geographic location on gallbladder cancer development. Peru has a high incidence of gallbladder cancer, but causative factors have not yet been identified. We examined the frequency of mutations in TP53 and K-ras genes in Peruvian patients with gallbladder cancer, and compared this with data from Bolivia, Hungary, Chile, and Japan, which have a high gallbladder cancer incidence. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.289DOI Listing
January 2019
1 Read

Is Periodontitis Independently Associated with Potentially Malignant Disorders of the Oral Cavity?

Asian Pac J Cancer Prev 2019 Jan 25;20(10):283-287. Epub 2019 Jan 25.

Department of Public Health Dentistry, Sharavathi Dental College and Hospital, Shimoga, India. Email:

Objective: To examine if periodontitis is independently associated with oral potentially malignant disorders (OPMD) in a rural Indian adult population aged 35-54 years. Methods: A population-based cross-sectional study was conducted in rural India from 2011 to 2012. Multistage stratified cluster random sampling was followed to recruit 1401 participants aged 35-54 years. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.283DOI Listing
January 2019

Expression of Vascular Endothelial Growth Factor and Its Receptors in Thyroid Nodular Hyperplasia and Papillary Thyroid Carcinoma: A Tertiary Health Care Centre Based Study

Asian Pac J Cancer Prev 2019 Jan 25;20(1):277-282. Epub 2019 Jan 25.

Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Email:

Introduction: Vascular endothelial growth factor (VEGF) is an angiogenic factor that plays an important role in thyroid cancer. VEGF is known to have high affinity to VEGF receptors such as VEGFR-1 (Flt-1) and VEGFR-2 (KDR). Papillary thyroid carcinoma (PTC) is the most common thyroid cancer and studies showed the increasing incidence of PTC arising in nodular hyperplasia. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.277DOI Listing
January 2019
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PTEN Genetic and Epigenetic Alterations Define Distinct Subgroups in North Indian Breast Cancer Patients

Asian Pac J Cancer Prev 2019 Jan 25;20(1):269-276. Epub 2019 Jan 25.

Department of Biosciences, Jamia Millia Islamia, New Delhi, India. Email:

Background: Breast cancer is a heterogeneous disease that can be subdivided on the basis of histopathological features, genetic alterations, and gene-expression profiles. PTEN gene is considered an established tumor suppressor gene in different types of cancer including breast cancer. However, the role of PTEN alterations in north Indian breast cancer has not been explored especially in defining a group with distinct histological factors. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.269DOI Listing
January 2019

Novel Combination of Mesenchymal Stem Cell-Conditioned Medium with Sorafenib Have Synergistic Antitumor Effect of Hepatocellular Carcinoma Cells

Asian Pac J Cancer Prev 2019 Jan 25;20(1):263-267. Epub 2019 Jan 25.

Tissue Engineering and Applied cell Sciences,Tehran University of Medical Sciences,Tehran, Iran. Email:

Objective: Hepatocellular carcinoma (HCC) is the most common liver malignancy. Sorafenib is the first-line systemic treatment for advanced HCCs. However, due to safety concerns, researchers are now looking for ways to boost the efficacy of the medication. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.263DOI Listing
January 2019
1.500 Impact Factor

Protease Cargo in Circulating Exosomes of Breast Cancer and Ovarian Cancer Patients

Asian Pac J Cancer Prev 2019 Jan 25;20(1):255-262. Epub 2019 Jan 25.

Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.

Background: As is known, exosomes play an important role in promoting progression of cancers by increasing its invasive potential. The aim of this study was to evaluate the levels of tetraspanine-associated (ADAM-10) and tetraspanine-nonassociated proteases (20S proteasomes) in exosomes from culture medium, plasma exosomes of patients with breast tumors and plasma and ascites of ovarian tumor patients. Methods: MCF-7 and SVO-3 culture mediums and blood samples from healthy females (n = 30, HFs), patients with diffuse dyshormonal dysplasia of the breast (n=28, BBTPs), breast cancer patients (n=32, BCPs), borderline ovarian tumor patients (n=20, BOTPs) and blood and ascites samples ovarian cancer patients (n=35, OCPs) were included in the study. Read More

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http://journal.waocp.org/article_81713.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.255DOI Listing
January 2019
4 Reads

Stromal Expression of CD10 by Immunohistochemistry in Odontogenic Keratocyst (OKC), Dentigerous and Radicular Cysts and Its Correlation with Local Recurrence and Aggressive Behaviour

Asian Pac J Cancer Prev 2019 Jan 25;20(1):249-253. Epub 2019 Jan 25.

Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan. Email:

Objective: To assess and compare the stromal expression of CD10 in OKC, dentigerous and radicular cysts. Materials and Methods: This comparative, cross sectional study was conducted at Armed Forces Institute of Pathology (AFIP), Rawalpindi, from Jan 2017 to Dec 2017. Total sixty cases comprising 20 of each OKC, Dentigerous and Radicular cysts were included in this study. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.249DOI Listing
January 2019

Useful Application of Immunostaining to Malignant Pleural Effusion among Lao People in Vientiane Capital, Lao PDR

Asian Pac J Cancer Prev 2019 Jan 25;20(1):243-248. Epub 2019 Jan 25.

Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Email:

Background: Pathology and laboratory medicine (PALM) services are limited in low-resource countries, such as Lao PDR. Patients with malignant pleural effusion (MPE) are not properly diagnosed and treated in these situations. The purpose of this study is to confirm the usefulness of immunocytochemistry in MPE to identify the histological type and probable primary site of cancer of MPE and to discuss its usefulness in low-resource countries, such as Laos. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.243DOI Listing
January 2019
1 Read

Cytogenetic Abnormalities in Multiple Myeloma Patients at a Tertiary Healthcare Center in India

Asian Pac J Cancer Prev 2019 Jan 25;20(1):235-241. Epub 2019 Jan 25.

Department of Centralised Molecular Diagnostics, Apollo Hospitals, Chennai-6, Tamil Nadu, India. Email:

Objective: Multiple myeloma (MM) is a clinically and genetically heterogeneous plasma cell neoplasm. The prognosis of MM patients is dependent on several factors including the patient’s age, the stage of disease and genetic alterations. This study aimed to determine the frequency of common chromosomal abnormalities and their significance in MM patients referred to a tertiary healthcare center in India. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.235DOI Listing
January 2019

Application of aSi-kVCBCT for Volume Assessment and Dose Estimation: An Offline Adaptive Study for Prostate Radiotherapy

Asian Pac J Cancer Prev 2019 Jan 25;20(1):229-234. Epub 2019 Jan 25.

Department of Radiation Oncology, Yashoda Hospital, Hyderabad, India.

Objective: The purpose of this study is to develop a method to estimate the dose using amorphous silicon detector panel cone beam computed tomography (aSi-kVCBCT) for the OARs and targets in prostate radiotherapy and to compare with the actual planned dose. Methods: The aSi-kVCBCT is used widely in radiotherapy to verify the patient position before treatment. The advancement in aSi-kVCBCT combined with adaptive software allows us to verify the dose distribution in daily acquired CBCT images. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.229DOI Listing
January 2019

Bioinformatics Analysis of Key Genes and Pathways for Medulloblastoma as a Therapeutic Target

Asian Pac J Cancer Prev 2019 Jan 25;20(1):221-227. Epub 2019 Jan 25.

Department of Cellular-Molecular Biology, Faculty of Biological Sciences and Technologies, Shahid Beheshti University. Tehran, Iran. Email:

Introduction: One of the major challenges in cancer treatment is the lack of specific and accurate treatment in cancer. Data analysis can help to understand the underlying molecular mechanism that leads to better treatment. Increasing availability and reliability of DNA microarray data leads to increase the use of these data in a variety of cancers. Read More

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http://journal.waocp.org/article_80109.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.221DOI Listing
January 2019
4 Reads

Studying the Impact of Golgi Protein 73 Serving as a Candidate Biomarker in Early Diagnosis for Hepatocellular Carcinoma among Saudi Patients

Asian Pac J Cancer Prev 2019 01 25;20(1):215-220. Epub 2019 Jan 25.

Health Sciences Research Center (HSCR), Princess Nourah bint Abdulrahman University (PNU), Kingdom Saudi Arabia. Email:

Background: Due to the prevalence of Hepatocellular carcinoma (HCC) in Saudi Arabia, using new markers to give best diagnostic performance than alpha-feto protein (AFP) are important in early diagnosis. The aim of this work was to compare the significance between serum and mRNA Golgi glypican73 (GP-73) as newly identified diagnostic and prognostic markers for HCC among Saudi patients. Materials and Methods: A total of 300 subjects were divided into: 250 blood samples where 145 samples from HCC, 105 samples from chronic liver cirrhosis (CLC) and 50 normal controls were investigated for serum GP73 (sGP73) by ELISA. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.215DOI Listing
January 2019
1 Read

Breast Cancer Screening Participation of Women with Chronic Diseases in Korea: Analysis of the 2012 Korean National Health and Nutrition Examination Survey

Asian Pac J Cancer Prev 2019 Jan 25;20(1):207-213. Epub 2019 Jan 25.

Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea. Email:

Chronic disease morbidity is a concern for cancer research. Contradictory results have been reported concerning adherence to breast cancer screening among patients with chronic diseases. The study was conducted to assess the adherence to breast cancer screening among women with chronic diseases in Korea. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.207DOI Listing
January 2019

Molecular Mechanism of Cancer Susceptibility Associated with Fok1 Single Nucleotide Polymorphism of VDR in Relation to Breast Cancer

Asian Pac J Cancer Prev 2019 Jan 25;20(1):199-206. Epub 2019 Jan 25.

Department of Biosciences, Integral University, Lucknow, India. Email:

Breast cancer is the leading cause of death among women worldwide. It is a multi-factorial disease caused by genetic and environmental factors. Vitamin D has been hypothesized to lower the risk of breast cancer via the nuclear vitamin D receptor (VDR). Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.199DOI Listing
January 2019
1 Read

MiR-126 Modulates Angiogenesis in Breast Cancer by Targeting VEGF-A -mRNA

Authors:
Layla Alhasan

Asian Pac J Cancer Prev 2019 Jan 25;20(1):193-197. Epub 2019 Jan 25.

Department of Biology, College Education for Pure Sciences, Thi-Qar University, Nasiriya, Iraq. Email: :

Background: Breast cancer is most serious reasons of women death around worldwide result in increasing its morbidity and mortality. MicroRNAs are considered as significant regulators of cancer biological processes. The main aim of this study is restoration of miR-126 could lead to modulate breast cell line and impairs their proliferation by targeting vascular endothelial growth factor gene (VEGF-A). Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.193DOI Listing
January 2019

Anti-Proliferative Effects of Methanol and Water Extracts of Pyrrosia piloselloides on the Hela Human Cervical Carcinoma Cell Line

Asian Pac J Cancer Prev 2019 Jan 25;20(1):185-192. Epub 2019 Jan 25.

Department of Biomedicine, School of Health Sciences, University Sains Malaysia (USM), Kubang Kerian, Kelantan, Malaysia. Email:

Background: Cervical cancer is one of the most commonly diagnosed neoplasms and a leading cause of cancer death among females worldwide. Limitations with conventional medical treatments have driven researchers to search for alternative approaches using natural products. This study aimed to detemine potential anti-proliferative effects of methanol and water extracts of Pyrrosia piloselloides (P. Read More

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http://journal.waocp.org/article_81711.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.185DOI Listing
January 2019
6 Reads

Plasma Peptidome Pattern of Breast Cancer Using Magnetic Beads-Based Plasma Fractionation and MALDI-TOF MS: A Case Control Study in Egypt

Asian Pac J Cancer Prev 2019 Jan 25;20(1):175-184. Epub 2019 Jan 25.

Department of Chemical Pathology, Medical Research Institute, Alexandria University, Egypt. Email:

Objective: The present study aimed to determine peptidome patterns in breast cancer (BC). Methods: We analyzed the plasma proteomic profiling of 80 BC patients and 50 healthy controls, using hydrophobic interaction chromatography magnetic beads (MB-HIC8) separation followed by Matrix assisted laser desorption ionization/ time of flight mass spectrometry (MALDI-TOF MS). Results: ClinProTools software identified 92 peaks that differed among the analyzed groups, 33 peaks were significantly different (P < 0. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.175DOI Listing
January 2019
1 Read

Active Contour Based Segmentation and Classification for Pleura Diseases Based on Otsu’s Thresholding and Support Vector Machine (SVM)

Asian Pac J Cancer Prev 2019 Jan 25;20(1):167-173. Epub 2019 Jan 25.

Department of Electronics and Instrumentation, Saveetha Engineering College, Chennai, India. Email:

Objective: Generally, lung cancer is the abnormal growth of cells that originates in one or both lungs. Finding the pulmonary nodule helps in the diagnosis of lung cancer in early stage and also increase the lifetime of the individual. Accurate segmentation of normal and abnormal portion in segmentation is challenging task in computer-aided diagnostics. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.167DOI Listing
January 2019

Breast Cancer Detection using Crow Search Optimization based Intuitionistic Fuzzy Clustering with Neighborhood Attraction

Asian Pac J Cancer Prev 2019 Jan 25;20(1):157-165. Epub 2019 Jan 25.

Department of Computer Technology, Kongu Engineering College, Perundurai, Tamilnadu, India. Email:

Objective: Generally, medical images contain lots of noise that may lead to uncertainty in diagnosing the abnormalities. Computer aided diagnosis systems offer a support to the radiologists in identifying the disease affected area. In mammographic images, some normal tissues may appear to be similar to masses and it is tedious to differentiate them. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.157DOI Listing
January 2019
1.500 Impact Factor

Identification of Key Candidate Genes and Pathways for Relationship between Ovarian Cancer and Diabetes Mellitus Using Bioinformatical Analysis

Asian Pac J Cancer Prev 2019 Jan 25;20(1):145-155. Epub 2019 Jan 25.

Department of Toxicology, Guilin Medical University School of Public Health, Guilin, China. Email:

Ovarian cancer is one of the three major gynecologic cancers in the world. The aim of this study is to find the relationship between ovarian cancer and diabetes mellitus by using the genetic screening technique. By GEO database query and related online tools of analysis, we analyzed 185 cases of ovarian cancer and 10 control samples from GSE26712, and a total of 379 different genes were identified, including 104 up-regulated genes and 275 down-regulated genes. Read More

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http://journal.waocp.org/article_81666.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.145DOI Listing
January 2019
3 Reads

Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma

Asian Pac J Cancer Prev 2019 Jan 25;20(1):139-143. Epub 2019 Jan 25.

Department of Biochemistry and Molecular Biology, National Hepatology and Tropical Medicine Research Institute, Cairo University, Cairo, Egypt. Email:

Introduction: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. There is a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer. The current study aimed at evaluation of the possible association between selected adiponectin gene polymorphism and the risk of pancreatic cancer. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.139DOI Listing
January 2019
1 Read

Behavior and Outcomes of Pregnancy Associated Breast Cancer

Asian Pac J Cancer Prev 2019 Jan 25;20(1):135-138. Epub 2019 Jan 25.

Section Medical Oncology, Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. Email:

Introduction: Pregnancy Associated Breast cancer (PABC) is associated with poor prognosis and a decreased overall survival. A retrospective review was conducted to review the experience and outcome in a tertiary care hospital, and to compare those seen in a matched group for year of diagnosis. Materials and Methods: This is a retrospective review of a prospectively collected breast cancer registry. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.135DOI Listing
January 2019
1 Read

Frequency of Polypharmacy in Advanced Cancer Patients Consulted with the Palliative Service of Imam Khomeini Hospital (Tehran), Iran, 2017

Asian Pac J Cancer Prev 2019 Jan 25;20(1):131-134. Epub 2019 Jan 25.

Department of Palliative Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Email:

Background: Polypharmacy is defined as the concurrent use of more than four or five medications by an individual. The prevalence of this condition has increased due to the ageing population and the related illnesses. Use of multiple medications would increase the risk of side-effects, drug interactions, and medical costs. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.131DOI Listing
January 2019

Evaluating of Induction of Apoptosis by Cornus mass L. Extract in the Gastric Carcinoma Cell Line (AGS)

Asian Pac J Cancer Prev 2019 Jan 25;20(1):123-130. Epub 2019 Jan 25.

Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Aim and objectives: Natural products and derivatives of medicinal vegetation can play an important role to the cure tumor. The Present study was focused to determine the effect of Cornus mass L. extract on the induction of apoptosis in AGS gastric carcinoma cell line in compared to L929 cells. Read More

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http://journal.waocp.org/article_80970.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.123DOI Listing
January 2019
3 Reads
1.500 Impact Factor

Comparison of Real Cost Versus the Indonesian Case Base Groups (INA-CBGs) Tariff Rates Among Patients of High- Incidence Cancers Under the National Health Insurance Scheme

Asian Pac J Cancer Prev 2019 Jan 25;20(1):117-122. Epub 2019 Jan 25.

Faculty of Pharmacy, University Gadjah Mada, Indonesia.Email:

Background: The national health insurance of Indonesia has implemented the Indonesian Case Base Groups (INA-CBGs) tariff rates for healthcare payment. However, there is still problem of difference between the real cost of healthcare and the INA-CBGs tariff rates. This study aimed to evaluate the real cost of healthcare in comparison with the INA-CBG’s tariff rates and to analyze factors associating with the real cost. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.117DOI Listing
January 2019
1 Read

Integrating a 92-Gene Expression Analysis for the Management of Neuroendocrine Tumors of Unknown Primary

Asian Pac J Cancer Prev 2019 Jan 25;20(1):113-116. Epub 2019 Jan 25.

Department of Internal Medicine, Division of Medical Oncology, University of Kentucky, Lexington, KY, United States. Email:

Background: Neuroendocrine tumors (NETs) are rare tumors that can originate from any part of the body. Often, imaging or exploratory surgery can assist in the identification of the tumor primary site, which is critical to the management of the disease. Neuroendocrine tumors (NETs) of unknown primary constitute approximately 10-15% of all NETs. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.113DOI Listing
January 2019

Overweight as an Additional Risk Factor for Colorectal Neoplasia in Lean Population

Asian Pac J Cancer Prev 2019 Jan 25;20(1):105-111. Epub 2019 Jan 25.

Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross, Bangkok, Thailand. Email:

Background: Overweight in Thailand is not as common as in Western countries. We sought to evaluate overweight as the additional risk factor that can increase the prediction of colorectal neoplasia (CRN) detection in Thais apart from the Asia-Pacific Colorectal Screening (APCS) score. Methods: We prospectively enrolled asymptomatic 338 subjects who underwent screening colonoscopy between November 2016 and September 2017. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.105DOI Listing
January 2019
3 Reads

Setting Priorities in Childhood Cancer in Low Income Countries Using Nominal Group Technique: Experience from an International Childhood Cancer Forum Exercise in Bangladesh

Asian Pac J Cancer Prev 2019 Jan 25;20(1):97-103. Epub 2019 Jan 25.

Department of Health Services Administration, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Background and Objectives: Cancer is one of the major causes of mortality and morbidity worldwide. The incidence of paediatric cancer in particular, in Bangladesh is alarming and most of these patients die without correct diagnosis and adequate medical treatment (MOHFW, 2008). There is a clear disparity in access to care between rural and urban areas (WHO, 2015; Rahman, 2001). Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.97DOI Listing
January 2019

Effect of Induction Chemotherapy on Swallowing in Head and Neck Cancer Patients

Asian Pac J Cancer Prev 2019 Jan 25;20(1):91-96. Epub 2019 Jan 25.

SLP Head and Neck Department, Barretos Cancer Hospital, Barretos-SP, Brazil. Email:

Objective: To evaluate the effect of induction chemotherapy on swallowing and swallowing-related quality of life of patients with oropharyngeal, laryngeal and hypopharyngeal cancer. Study design: Prospective study of 33 patients with locally advanced tumors who were eligible for treatment with neoadjuvant chemotherapy followed by radiotherapy and concurrent chemotherapy. A multidimensional assessment of swallowing was performed using the following tools: (1) Clinical analysis, numerical scale for general pain and painful swallowing, American Speech and Hearing Association (ASHA) Functional Communication Measures (FCM) swallowing assessment scales, (2) assessment of Swallowing-Related Quality of Life (The MD Anderson Dysphagia Inventory - MDADI), and (3) swallowing videofluoroscopy. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.91DOI Listing
January 2019
1 Read

Estimating Premature Mortality Cost of Cancers Attributable to Obesity in Indonesia

Asian Pac J Cancer Prev 2019 Jan 25;20(1):87-90. Epub 2019 Jan 25.

Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia. Email:

Obesity is one of the risk factor of non-communicable diseases, one of them is cancer. It may lead to the escalation of mortality. Indonesia is the top 10 country with the highest prevalence of cancer burden due to obesity. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.87DOI Listing
January 2019
1 Read

The Impact of Triage for Atypical Squamous Cells of Undetermined Significance with Human Papillomavirus Testing in Cervical Cancer Screening in Japan

Asian Pac J Cancer Prev 2019 Jan 25;20(1):81-85. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan. Email:

Background: One of the features of cervical cancer screening using the combination of cytology and human papillomavirus (HPV) testing is the triage for atypical squamous cells of undetermined significance (ASC-US). The effectiveness of the triage has been recognized widely. However, there are few reports evaluating this triage process in Japan. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.81DOI Listing
January 2019
5 Reads

Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas

Asian Pac J Cancer Prev 2019 Jan 25;20(1):73-79. Epub 2019 Jan 25.

Department of Pathology, School of Medicine, Alassane Ouattara University, BP V 18 Bouake, Ivory Coast.Email:

Background: Patients primarily received tamoxifen based on their menopausal status due to the lack of immunohistochemistry. A recent study has shown that hormonal receptors were not correlated with menopausal status, and thus, indicating that they present limited therapeutic and prognostic significance in breast cancer management. This study aimed to evaluate Ki-67 value and analyze its association with clinicopathologic parameters in breast cancer patients. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.73DOI Listing
January 2019
2 Reads

Antimetastatic Potential of Garcinone E in Human Oral Cancer Cells

Authors:
Sheeja K Lakshmi S

Asian Pac J Cancer Prev 2019 Jan 25;20(1):65-72. Epub 2019 Jan 25.

Laboratory of Molecular Medicine, Division of Cancer Research, Regional Cancer Centre, Medical College, Thiruvanananthapuram, Kerala, India. Email:

Objective: Oral cancer presents as a devastating type of malignancy. It is predominant in populations with high use of alcohol and various forms of tobacco as well as poor diets with low intake of fruits and vegetables. The present study focused on the potential of Garcinone E to inhibit HSC-4 oral cancer cell proliferation, migration and invasion. Read More

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http://journal.waocp.org/article_81719.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.65DOI Listing
January 2019
4 Reads
1.500 Impact Factor

Nottingham Prognostic Index is an Applicable Prognostic Tool in Non-Metastatic Triple-Negative Breast Cancer

Asian Pac J Cancer Prev 2019 Jan 25;20(1):59-63. Epub 2019 Jan 25.

Service of Medical Oncology, University Hospital Mohammed VI-Oujda, Morocco. Email:

Introduction: Triple-negative breast cancer (TNBC) is characterized by a poor prognosis due to high mortality and early relapse, requiring the study of its prognostic factors. Tumor size, histological grade and lymph node status represent important parameters that are widely studied in breast cancer, and are retained as prognostic factors by several international guidelines. The Nottingham team combined these parameters into a prognostic score called the Nottingham prognostic index (NPI). Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.59DOI Listing
January 2019

The Correlation of Blood Parameters with Size in Cases of Neoplastic Tumor

Asian Pac J Cancer Prev 2019 Jan 25;20(1):53-57. Epub 2019 Jan 25.

Radiotherapy Development Department in Provincial Multidisciplinary Hospital in Gorzów Wielkopolski, ul Dekerta 1, 66-400 Gorzow Wielkopolski LLC, Poland.

Purpose: This study aimed to evaluate the impact of tumor volume on platelet counts (PLT) and mean platelet volume (MPV) and involve these parameters on overall survival. Methods: It is a retrospective study of 99 patients with lung cancer (confirmed histologically or cytologically). Sixty-six patients underwent radical operating treatment and 33 patients had only biopsies – due to the inoperable status of tumor According to the histopathology profile: non-small cell carcinoma – 23%, adenocarcinoma - 23 %, squamous - 36%, small cell carcinoma -11%, carcinoid – 6%. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.53DOI Listing
January 2019
1 Read

Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer

Asian Pac J Cancer Prev 2019 Jan 25;20(1):45-51. Epub 2019 Jan 25.

National Cancer Institute and Federal University of the State of Rio de Janeiro, Rio de Janeiro , Brazil. Email:

Background: Bone is a frequent site of metastasis from various primary cancers including with Non-Small Cell Lung Cancer. The aim of this study was to investigate the incidence and risk factors for Bone Metastasis in patients with Non-Small Cell Lung Cancer. Methodology: A cohort study was carried out in patients diagnosed with Non-Small Cell Lung Cancer between 2006 and 2014 in a single cancer centre. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.45DOI Listing
January 2019

Polycythaemia Vera among Sudanese Patients with Special Emphasis on JAK2 Mutations

Asian Pac J Cancer Prev 2019 Jan 25;20(1):41-44. Epub 2019 Jan 25.

Department of Haematology, Faculty of Medical Laboratory Sciences, Al-Neelain University, Khartoum, Sudan.

Background: In recent years, a somatic point mutation in the Janus Kinase 2 (JAK2) gene (1849 G→T, V617F) has been reported to occur in over 90% of patients with polycythemia vera (PV). Another JAK2 mutation in exon 12 had been described and shown capable of activating erythropoietin signaling pathways. Objective: In this study, we aimed to determine the frequency of Jak2 mutations (JAK2V617F and JAK2 exon 12) as well as their relationships with hematological parameters in Sudanese patients with myeloproliferative disorders (MPD). Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.41DOI Listing
January 2019
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Factors Related to Employment Situation among Korean Cancer Survivors: Results from a Population-Based Study

Asian Pac J Cancer Prev 2019 Jan 25;20(1):33-40. Epub 2019 Jan 25.

College of Nursing, The Catholic University of Korea, Seoul, Republic of Korea. *For Correspondence:

Background: Due to the increased incidence and survival rate of cancer, the number of cancer survivors has been increasing. In addition, many problems have been reported regarding the employment of these survivors. Therefore, this study aims to investigate the employment situation of cancer survivors and associated factors. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.33DOI Listing
January 2019

Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management

Asian Pac J Cancer Prev 2019 Jan 25;20(1):23-32. Epub 2019 Jan 25.

Department of Human Anatomy, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, P.R, China. Email:

The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved serine/ threonine kinase overexpressed in various human carcinomas and its high expression often correlates with poor prognosis. CK2 protein is localized in the nucleus of many tumor cells and correlates with clinical features in many cases. Increased expression of CK2 in mice results in the development of various types of carcinomas (both solids and blood related tumors, such as (breast carcinoma, lymphoma, etc), which reveals its carcinogenic properties. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.23DOI Listing
January 2019

Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis

Asian Pac J Cancer Prev 2019 Jan 25;20(1):13-21. Epub 2019 Jan 25.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences Tehran, Iran.Email:

Background: Different studies have been conducted to estimate the survival rate of colorectal cancer in Iran but there is no overall estimate of the survival rate. The aim of this study was to calculate the pooled 1, 3, and 5-year survival rate of the patients with colorectal cancer in Iran. Methods: To retrieve relevant studies, we conducted a systematic search in Iranian databases, including Iran Medex, Magiran, SID, and international databases such as Medlin/PubMed, Scopus, and Google scholar using “Colorectal Neoplasms” and “Survival Rate” as keywords up to December 1st, 2017. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.13DOI Listing
January 2019

A Review of Gastric Cancer Research in Malaysia

Asian Pac J Cancer Prev 2019 Jan 25;20(1):5-11. Epub 2019 Jan 25.

Department of Surgery, Clinical Campus, International Medical University, Jalan Rasah, Seremban, Negeri Sembilan, Malaysia. Email:

Incidence rates of gastric cancer in Malaysia has declined by 48% among males and 31% among females in the latest reporting period of 13 years. Malays used to have age-standardized-rates only a fifth of those in Chinese and Indians, but the incidence among them is slightly rising even as the rates drop in the other races. Besides ethnicity, a low level of education, high intake of salted fish and vegetables, H pylori infection and smoking are risk factors. Read More

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http://journal.waocp.org/article_81800.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.5DOI Listing
January 2019
2 Reads

Prevalence of EGFR Mutations and Clinico-Pathological Characteristics of Chilean Lung Cancer Patients

Asian Pac J Cancer Prev 2019 Jan 25;20(1):1-4. Epub 2019 Jan 25.

Department of Pathology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile. Email:

Background: Lung cancer (LC) is the second leading cause of cancer death in Chile, causing >3,000 deaths every year. Epidemiological LC data in Chile is scarce and scattered. Here, we aimed to quantify the prevalence of Epidermal Growth Factor Receptor (EGFR) gene mutations in a Chilean cancer center. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.1DOI Listing
January 2019
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Prevention of Malignant Transformation of Oral Leukoplakia and Oral Lichen Planus Using Laser: An Observational Study

Asian Pac J Cancer Prev 2018 Dec 25;19(12):3635-3641. Epub 2018 Dec 25.

Department of Oral Medicine and Radiology, M. M. College of Dental Sciences and Research, Mullana, Ambala, Haryana, India. Email:

Objectives: The present observational study was conducted with an aim to evaluate the efficacy of diode laser in management of homogenous oral leukoplakia (OL) and reticular oral lichen planus (OLP), so that these potentially malignant disorders can be limited and further malignant transformation can be prevented. Further the assessment of associated postoperative complications after laser therapy was also carried out. Study Design: Present study was carried out using diode laser 810nm on 60 subjects, of whom 30 subjects were of homogenous OL and 30 subjects were of reticular OLP aged between 20 – 60 years, the diagnosis of which was histopathologically confirmed. Read More

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http://journal.waocp.org/article_80075.html
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http://dx.doi.org/10.31557/APJCP.2018.19.12.3635DOI Listing
December 2018
2 Reads
1.500 Impact Factor

Risk Factors and Prognosis of Spontaneously Ruptured Hepatocellular Carcinoma in Thailand

Asian Pac J Cancer Prev 2018 Dec 25;19(12):3629-3634. Epub 2018 Dec 25.

Gastroenterology Unit, Department of Medicine, Faculty of Medicine, Thammasat University Hospital, Pathumthani, Thailand. Email:

Objective: Hepatocellular carcinoma (HCC) is the fatal cancer worldwide. Spontaneously Rupture remains important complication of HCC. The incidence of spontaneous HCC rupture was high in ASEAN but limited studies were reported. Read More

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http://journal.waocp.org/article_77415.html
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http://dx.doi.org/10.31557/APJCP.2018.19.12.3629DOI Listing
December 2018
14 Reads

Lymph Node Ratio: Is It an Independent Prognostic Factor for Stage III Cutaneous Melanoma?

Asian Pac J Cancer Prev 2018 Dec 25;19(12):3623-3627. Epub 2018 Dec 25.

Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Email:

Objective: Lymph node ratio (LNR) is defined as the ratio of the number of metastatic lymph nodes to the dissected lymph nodes. LNR is a prognostic factor for many tumor types. The present study aimed to evaluate the prognostic value of LNR in melanoma. Read More

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http://dx.doi.org/10.31557/APJCP.2018.19.12.3623DOI Listing
December 2018
1 Read

Diagnostic Accuracy of Axillary Ultrasonography Compared with Intra-operative Pathological Findings in Patients with Breast Cancer

Asian Pac J Cancer Prev 2018 Dec 25;19(12):3615-3621. Epub 2018 Dec 25.

Breast Cancer Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Email:

Objective: Breast cancer is the most common cancer and leading cause of mortality in women worldwide. Diagnosis of axillary lymph node involvement, frequently by axillary ultrasonography (AUS), is an important step in patients with primary breast cancer, while the gold standard pathological examination is only applicable during surgery. Thus, we aimed to evaluate the predictive value of AUS in detection of lymph node involvement. Read More

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http://dx.doi.org/10.31557/APJCP.2018.19.12.3615DOI Listing
December 2018
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Rhinacanthin-C Extracted from Rhinacanthus nasutus (L.) Inhibits Cholangiocarcinoma Cell Migration and Invasion by Decreasing MMP-2, uPA, FAK and MAPK Pathways

Asian Pac J Cancer Prev 2018 Dec 25;19(12):3605-3613. Epub 2018 Dec 25.

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Cholangiocarcinoma is a malignant tumor with high metastatic and mortality rates. We investigated the effects of rhinacanthin-C on cell proliferation, migration, invasion and the expression of proteins regulating cancer cell invasion-regulated proteins in a cholangiocarcinoma (KKU-M156) cell line. Cytotoxicity of rhinacanthin-C was determined by the SRB assay. Read More

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http://dx.doi.org/10.31557/APJCP.2018.19.12.3605DOI Listing
December 2018
2 Reads