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    Thioredoxin-Interact ing-Pro t e in [TXNIP] and Transglutaminase 2 [TGM2] Expression in Meningiomas of Different Grades and the Role of Their Expression in Meningioma Recurrence and Prognosis
    Asian Pac J Cancer Prev 2017 08 27;18(8):2299-2308. Epub 2017 Aug 27.
    Pathology Department, Faculty of Medicine, Zagazig University, Egypt. Email:
    Background: Meningiomas are common central nervous system (CNS) tumors that account for thirty percent of primary intracranial tumors.. The accuracy of predicting meningioma recurrence and progression is not enough. Read More

    Survival of Patients with Thyroid Cancer in Yazd, Iran
    Asian Pac J Cancer Prev 2017 08 27;18(8):2293-2297. Epub 2017 Aug 27.
    Department of Internal Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
    Background: Thyroid cancer is the most common endocrine related malignancy in the world. This cancer has increased during recent years in Iran and is the11th most common malignancy in Iranian population. Survival of patients with thyroid carcinoma in the different geographic areas within Iran is not clear. Read More

    Effects of a Phosphoinositide-3-Kinase Inhibitor on Anaplastic Thyroid Cancer Stem Cells
    Asian Pac J Cancer Prev 2017 08 27;18(8):2287-2291. Epub 2017 Aug 27.
    Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:
    Background: Thyroidectomy, radioactive iodine therapy, chemotherapy, or their combination are treatments of choice for thyroid cancers. However, cancer stem cells (CSCs) may become resistant to therapy, and mutations in somatic genes affect radioiodine uptake. This study determined the effect of a phosphoinositide-3-kinase (PI3K) inhibitor on anaplastic thyroid CSCs. Read More

    Screening for Circulating Tumour Cells Allows Early Detection of Cancer and Monitoring of Treatment Effectiveness: An Observational Study
    Asian Pac J Cancer Prev 2017 08 27;18(8):2275-2285. Epub 2017 Aug 27.
    National Institute of Integrative Medicine (NIIM), Melbourne, Australia. Email:
    Background: Circulating-Tumour-Cells (CTC) provide a blood biomarker for early carcinogenesis, cancer progression and treatment effectiveness. An increase in CTCs is associated with cancer progression, a CTC decrease with cancer containment or remission. Several technologies have been developed to identify CTC, including the validated Isolation-by-Size-of-Epithelial-Tumour (ISET, Rarecells) technology, combining blood filtration and microscopy using standard histo-pathological criteria. Read More

    Upregulation of Galectin-9 and PD-L1 Immune Checkpoints Molecules in Patients with Chronic Lymphocytic Leukemia
    Asian Pac J Cancer Prev 2017 08 27;18(8):2269-2274. Epub 2017 Aug 27.
    Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Deviation of host immune response by engagement of inhibitory receptors is one of the well-known mechanisms of tumor cells for immune evasion and survival. PD-1/PD-L1 and Tim-3/Gal-9 axes are two major pathways in this area which their contribution has been documented in a variety of malignancies. In this study, Gal-9 and PD-L1 expression was investigated in leukemic cells from patients with Chronic Lymphocytic Leukemia (CLL). Read More

    Poly-L-Lysine Inhibits Tumor Angiogenesis and Induces Apoptosis in Ehrlich Ascites Carcinoma and in Sarcoma S-180 Tumor
    Asian Pac J Cancer Prev 2017 08 27;18(8):2255-2268. Epub 2017 Aug 27.
    Pharmacology Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, India.
    Background: This study focuses on the role of Poly-L-lysine (PLL), an essential amino acid, on molecular changes of tumor angiogenesis suppression, pro-apoptotic and anti-apoptotic gene expression after treatment on Ehrlich ascites carcinoma (EAC) and solid sarcoma-180 tumor cells bearing mice. Materials and Methods: The cell viability was carried out using MTT assay. The antitumor activity was evaluated by treatment with PLL at 20 and 40mg/kg/b. Read More

    Active Expression of Human Tissue Plasminogen Activator (t-PA) c-DNA from Pulmonary Metastases in the Methylotrophic Yeast Pichia Pastoris KM71H Strain
    Asian Pac J Cancer Prev 2017 08 27;18(8):2249-2254. Epub 2017 Aug 27.
    Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
    Background: Human tissue-type plasminogen activator (t-PA) is a key protease of the trypsin family. It catalyzes the activation of zymogen plasminogen to the fibrin-degrading proteinase, plasmin, leading to digestion of fibrin clots. The recombinant enzyme produced by recombinant technology issued to dissolve blood clots in treatment of various human diseases such as coronary artery thrombosis, pulmonary embolism, acute ischemic stroke (AIS). Read More

    Adjuvant Therapy with Silibinin Improves the Efficacy of Paclitaxel and Cisplatin in MCF-7 Breast Cancer Cells
    Asian Pac J Cancer Prev 2017 08 27;18(8):2243-2247. Epub 2017 Aug 27.
    Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Email:
    Herbal-derived medicines have introduced as sources of novel drugs due to minimum systemic side effects. Silibinin as a flavonoid compound has showed with effective chemotherapeutic effects on different cancers. Here, we investigated the impact of combination therapy of silibinin, with paclitaxel and cisplatin in inhibition of proliferation and induction of apoptosis in MCF-7 cells. Read More

    Cytological Features Associated with Ureaplasma Urealyticum in Pap Cervical Smear
    Asian Pac J Cancer Prev 2017 08 27;18(8):2239-2242. Epub 2017 Aug 27.
    Department of Medical technology, Faculty of Health Sciences, Kyorin University, Japan.
    Purpose: Ureaplasma urealyticum is associated with several obstetric complications and increases the importance of risk management in pregnant women. Furthermore, U. urealyticum has been identified as a cofactor that interacts with human papillomavirus infection in cervical cancer onset. Read More

    Effect of Frequency and Duration of Tobacco Use on Oral Mucosal Lesions – A Cross-Sectional Study among Tobacco Users in Hyderabad, India
    Asian Pac J Cancer Prev 2017 08 27;18(8):2233-2238. Epub 2017 Aug 27.
    Purpose: Tobacco use is one of the most important risk factors for the development of oral mucosal lesions including oral pre-cancer and cancer. The type and location of the lesion varies with the type of tobacco used, the way it is used, and the frequency and duration of use. Hence, the present study aimed to determine the effect of frequency and duration of tobacco use on oral mucosal lesions among tobacco users in Hyderabad city. Read More

    Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios are Not Different among Breast Cancer Subtypes
    Asian Pac J Cancer Prev 2017 08 27;18(8):2227-2231. Epub 2017 Aug 27.
    Samsun Training and Research Hospital, Medical Oncology Department, Samsun, Turkey. Email: yersal1978@
    Background: Breast cancer is a heterogeneous complex of diseases comprising different subtypes that have different treatment responses and clinical outcomes. Systemic inflammation is known to be associated with poor prognosis in many types of cancer. The neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) are factors used as indicators of inflammation. Read More

    The Effect of Health Belief Model-Based Education through Telegram Instant Messaging Services on Pap smear performance
    Asian Pac J Cancer Prev 2017 08 27;18(8):2221-2226. Epub 2017 Aug 27.
    Department of Health, Bushehr University of Medical Sciences, Bushehr, Iran. Email:
    Background: Pap smear is an effective screening method for early detection of cervical cancer. This study aimed to investigate the effect of education based on Health Belief Model (HBM) through Telegram instant messaging services on the Pap smear test. Material and methods: This research was a quasi-experimental study which was performed on 106 eligible women (48 participants in the intervention group and 47 participants in the control group). Read More

    CD24 and Nanog expression in Stem Cells in Glioblastoma: Correlation with Response to Chemoradiation and Overall Survival
    Asian Pac J Cancer Prev 2017 08 27;18(8):2215-2219. Epub 2017 Aug 27.
    Department of Pathology, Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. Email:
    Background and aim: Glioblastoma (GBM) is one of the most common and aggressive brain tumors with a median survival of 12-14 months. The aim of present study was to evaluate the gene expression profile of stem cell markers Nanog and CD24 in GBM and to determine its relationship to outcome in terms of treatment response and overall survival. Material and methods: This was a retrospective as well as retrospective study which included 51 histologically confirmed cases of GBM. Read More

    BRAF, KRAS and PIK3CA Mutation and Sensitivity to Trastuzumab in Breast Cancer Cell Line Model
    Asian Pac J Cancer Prev 2017 08 27;18(8):2209-2213. Epub 2017 Aug 27.
    Division of Biochemistry and Genetics American International Medical University Saint Lucia, United States. Email:
    Studies show that approximately 20% of all breast cancer patients have a breast tumor that tests positive for Human Epidermal Growth Factor Receptor 2, otherwise known as the HER2 gene. As such, treatments for breast cancer usually include drugs that target HER2. The drug Trastuzumab is a recombinant antibody that has been approved by the FDA for the treatment of these HER2 positive breast cancers. Read More

    Naja Naja Oxiana Venom Fraction Selectively Induces ROS-Mediated Apoptosis in Human Colorectal Tumor Cells by Directly Targeting Mitochondria
    Asian Pac J Cancer Prev 2017 08 27;18(8):2201-2208. Epub 2017 Aug 27.
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:
    Objective: To investigate the selective effect of Naja naja oxiana crude venom and its fractions on human colorectal cancer mitochondria to activate apoptosis signaling. Methods: Cells and mitochondria isolated from human cancerous and normal colorectal tissues exposed to N. oxiana crude venom and its fractions obtained from size-exclusion chromatography and then mitochondrial parameters related to up-stream cell death signalling such as reactive oxygen species formation, MMP, mitochondrial swelling, cytochrome c release and ATP content as mitochondrial parameters and activation of caspase3 and finally apoptosis/necrosis % were then assayed as cellular parameters. Read More

    Development of a Colorectal Cancer Screening Intervention for Iranian Adults: Appling Intervention Mapping
    Asian Pac J Cancer Prev 2017 08 27;18(8):2193-2199. Epub 2017 Aug 27.
    Department of Public Health, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran. Email:
    Background: While the incidence rate of the colorectal cancer (CRC) has been increasing over the last three decades in Iran, very limited interventions to increase CRC screening have been developed for Iranian population. The purpose of this study was to describe the use of Intervention Mapping (IM) for applying theory and evidence and considering local contexts to develop a CRC screening program among adults in Iran. Materials and Methods: From April 2014 to July 2016 following the IM process, six steps were formulated and implemented. Read More

    Evaluation of miR-711 as Novel Biomarker in Prostate Cancer Progression
    Asian Pac J Cancer Prev 2017 08 27;18(8):2185-2191. Epub 2017 Aug 27.
    Molecular and Cell Biology, Department of Biochemistry, King George’s Medical University, Lucknow, U.P. India
    Objective: MicroRNAs (miRs) are class of small non-coding regulatory RNA aberrantly expressed in various types of malignancies including prostate cancer and serves as potential targets to develop new diagnostic and therapeutic strategies. In this quiet we investigated miRNAs expression profile in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) tissue samples and correlated their expression with clinicopathological parameters. Methodology: The miRNAs expression profile as well as their validation has been done by using Microarray and RT-PCR, respectively. Read More

    Plasma Calcitonin Levels and miRNA323 Expression in Medullary Thyroid Carcinoma Patients with or without RET Mutation
    Asian Pac J Cancer Prev 2017 08 27;18(8):2179-2184. Epub 2017 Aug 27.
    Department of clinical biochemistry, Faculty of Medical Sciences, Shahrekord University of Medical Science, Shahrekord, Iran. Email:
    Background: Medullary thyroid cancer (MTC) is an endocrine tumor featuring parafollicular or C-cell differentiation, with calcitonin as a specific biomarker in MTC diagnosis. Germline mutations in the RET proto-oncogene are considered responsible for its familial occurrence and somatic mutations can cause sporadic lesions. MicroRNAs can act as oncogenes or tumor suppressors by inhibiting the expression of target genes. Read More

    Overexpression of Antiangiogenic Vascular Endothelial Growth Factor Isoform and Splicing Regulatory Factors in Oral, Laryngeal and Pharyngeal Squamous Cell Carcinomas
    Asian Pac J Cancer Prev 2017 08 27;18(8):2171-2177. Epub 2017 Aug 27.
    Genetics and Molecular Biology Research Unit, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, Brazil. Email:
    Background: Overexpression of proangiogenic vascular endothelial growth factor A family VEGFAxxx is associated with tumor growth and metastasis. The role of the alternatively spliced antiangiogenic family VEGFAxxxb is poorly investigated in head and neck squamous cell carcinomas (HNSCCs). The antiangiogenic isoform binds to bevacizumab and its expression level could influence the treatment response and progression-free survival. Read More

    Investigating Factors Associated with FOBT Screening for Colorectal Cancer Based on the Components of Health Belief Model and Social Support
    Asian Pac J Cancer Prev 2017 08 27;18(8):2163-2169. Epub 2017 Aug 27.
    Department of Public Health, School of Health, Fasa University of Medical Sciences, Fasa. Email:
    Introduction: This study aimed to investigate the factors associated with FOBT screening for colorectal cancer based on the components of Health Belief Model and social support in Fasa City, Fars Province, Iran. Materials and Methods: This was a cross-sectional study carried out on 240 subjects in people of Fasa city who had 50 years old and above. The subjects in this study were assigned to two groups of 120 patients. Read More

    The Association between Lifestyle, Occupational, and Reproductive Factors and Colorectal Cancer Risk
    Asian Pac J Cancer Prev 2017 08 27;18(8):2157-2162. Epub 2017 Aug 27.
    Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:
    Objective: Association of lifestyle, reproductive and environmental factors has been investigated with increased risk of colorectal cancer in different studies. We explored evidence and investigated association between various risk factors and colorectal cancer. Methods: This case- control study was conducted 155 colorectal cancer patients and 150 hospital-controls. Read More

    Cancer Prevalence in Aichi, Japan for 2012: Estimates Based on Incidence and Survival Data from Population-Based Cancer Registries
    Asian Pac J Cancer Prev 2017 08 27;18(8):2151-2156. Epub 2017 Aug 27.
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Japan.
    Background: Cancer is the leading cause of death among both men and women in Japan. Monitoring cancer prevalence is important because prevalence data play a critical role in the development and implementation of health policy. We estimated cancer prevalence in 2012 based on cancer incidence and 5-year survival rate in Aichi Prefecture using data from a population-based cancer registry, the Aichi Cancer Registry, which covers 7. Read More

    Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart
    Asian Pac J Cancer Prev 2017 08 27;18(8):2141-2149. Epub 2017 Aug 27.
    Hormones Department, Medical Research Division, National Research Centre, Giza, Egypt. Email:
    Medicinal plants are important elements of indigenous medical system that have persisted in developing countries. Many of the botanical chemo-preventions currently used as potent anticancer agents. However, some important anticancer agents are still extracted from plants because they cannot be synthesized chemically on a commercial scale due to their complex structures that often contain several chiral centers. Read More

    Neem Seed Oil Induces Apoptosis in MCF-7 and MDA MB-231 Human Breast Cancer Cells
    Asian Pac J Cancer Prev 2017 08 27;18(8):2135-2140. Epub 2017 Aug 27.
    Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, India. Email:
    Background: In traditional Indian medicine, azadirachta indica (neem) is known for its wide range of medicinal properties. Various parts of neem tree including its fruit, seed, bark, leaves, and root have been shown to possess antiseptic, antiviral, antipyretic, anti-inflammatory, antiulcer, antimalarial, antifungal and anticancer activity. Materials and Methods: MCF-7 and MDA MB-231 cells were exposed to various concentrations of 2% ethanolic solution of NSO (1-30 μl/ml) and further processed for cell viability, cell cycle and apoptosis analysis. Read More

    Increasing Awareness of Gynecologic Cancer Risks and Symptoms among Asian, Native Hawaiian and Pacific Islander Women in the US-Associated Pacific Island Jurisdictions
    Asian Pac J Cancer Prev 2017 08 27;18(8):2127-2133. Epub 2017 Aug 27.
    Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States. Email:
    Background: Gynecologic cancers are common among Asian/Native Hawaiian/Pacific Islander (A/NH/PI) women. Prevention is important in United States associated Pacific Island jurisdictions (USAPIJ) because there are limited resources to treat cancer. The objective of this study was to educate A/NH/PI women and providers about evidence-based interventions to prevent and control gynecologic cancers in Yap, one of four major islands comprising the Federated States of Micronesia (FSM). Read More

    Colorectal Cancer and Precancerous Lesions Associated with Ulcerative Colitis in Thailand
    Asian Pac J Cancer Prev 2017 08 27;18(8):2123-2126. Epub 2017 Aug 27.
    Gastroenterology Unit, Thammasat University Hospital, Pathumthani, Thailand.
    Background: Ulcerative colitis(UC) is important risk factor of colorectal cancer. Many evidences from western countries confirmed this relationship but limited studies were reported in ASEAN. This study was aimed to investigate prevalence, clinical presentations, endoscopic findings, histopathology, disease progression and risk for colorectal cancer(CRC) of UC patients in Thailand. Read More

    Association of Cervical Cancer Screening with Knowledge of Risk Factors, Access to Health Related Information, Health Profiles, and Health Competence Beliefs among Community-Dwelling Women in Japan
    Asian Pac J Cancer Prev 2017 08 27;18(8):2115-2121. Epub 2017 Aug 27.
    Graduate School of Health Sciences, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma, Japan. Email:
    Objective: The aim of this study was to evaluate the past attendance for cervical cancer screening with knowledge of risk factors, access to health-related information, health profiles and health competence beliefs among Japanese women. Methods: Women ages 25, 30, 35, 40, 45, 50, 55, and 60 were contacted cross-sectionally as part of a project for the Japanese Ministry of Health, Labour and Welfare in Nikaho, Akita prefecture Japan between June 2010 and March 2011, and 249 women were analyzed for the current study. The questionnaire asked about past cervical cancer screening. Read More

    Perioperative Liver Function after Hepatectomy in a Tertiary University Hospital in Damascus
    Asian Pac J Cancer Prev 2017 08 27;18(8):2109-2113. Epub 2017 Aug 27.
    Faculty of Medicine, Damascus University, Damascus, Syria. Email:
    Background: Liver resection is the only viable therapeutic treatment option for several neoplastic entities of the liver. Although, the number of resectable patients is increasing in Syria, liver failure is still a major complication affecting mortality and morbidity rates. Methods: Between 2009 and 2016, 104 patients undergoing liver resection in Damascus University Faculty of Medicine were retrospectively analyzed. Read More

    Homeodomain Protein Transforming Growth Factor Beta-Induced Factor 2 Like, X-Linked Function in Colon Adenocarcinoma Cells
    Asian Pac J Cancer Prev 2017 08 27(18):2101-2108. Epub 2017 Aug 27.
    Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran. Email:
    Background: TGIF2LX (transforming growth factor beta-induced factor 2 like, X-linked) is a homeodomain (HD) protein that has been implicated in the negative regulation of cell signaling pathways. The aim of this study was to investigate the possible functions of TGIF2LX in colon adenocarcinoma cells. Methods: The human SW48 cell line was transfected with cDNA for the wild-type TGIF2LX gene and gene/protein over-expression was confirmed by microscopic analysis, real time RT-PCR and Western blotting techniques. Read More

    Prospective Evaluation of Quality of Life in Patients Undergoing Primary Surgery for Oral Cancer: Preoperative and Postoperative Analysis
    Asian Pac J Cancer Prev 2017 08 27;18(8):2093-2100. Epub 2017 Aug 27.
    Department of Oral Medicine, School of Dentistry, Federal University of Ceará (UFC), Rua Alexandre Baraúna 949, Rodolfo Teófilo, Fortaleza, Ceará, Brazil. Email:
    Background: The purpose of the present study was to compare the preoperative and postoperative health related quality of life (HRQoL) of a sample of patients undergoing primary surgery for oral cancer in 2012-13. Materials and Methods: A cross-sectional, prospective study of 54 patients in a Brazilian population was performed. HRQoL was measured preoperatively (after histopathological diagnosis) and postoperatively (2 months after surgery) using the University of Washington Quality of Life Questionnaire (UW-QOL). Read More

    Investigating the Quality of Life and the Related Factors in Iranian Women with Breast Cancer
    Asian Pac J Cancer Prev 2017 08 27;18(8):2089-2092. Epub 2017 Aug 27.
    Department of Radiotherapy, Ghaem Hospital, Radiation Oncology Center Reza, Mashhad University of Medical Sciences, Mashhad, Iran. Email:
    Introduction: Nowadays breast cancer is the most important factor concerning the women’s health which can affect the quality of life (QOL). This study was performed with aim to investigate the QOL and the related factors in Iranian women diagnosed with breast cancer in 2014-2015. Methods: This cross-sectional study was performed on 94 women with breast cancer who were selected by convenience sampling in Mashhad, Iran from 2014-2015. Read More

    Pregnancy Outcomes after Conservative Surgery for Early-Stage Ovarian Neoplasms
    Asian Pac J Cancer Prev 2017 08 27;18(8):2083-2087. Epub 2017 Aug 27.
    Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. Email:
    Objective: This retrospective, single institute study aimed to evaluate pregnancy and oncologic outcomes in reproductive-age Thai women with early-stage ovarian neoplasms undergoing conservative surgical treatment. Methods: Medical records of 84 women of reproductive age (15-45 years) with histologically confirmed early-stage (IA-IIC) borderline ovarian tumors or cancers who had undergone conservative surgery between January 2003 and December 2012 were retrospectively reviewed. Results: The mean age of patients at diagnosis was 28. Read More

    Managing the Axilla in Early Breast Cancer. Impact of ACOSOG Z0011 Trial in Changing Practices in a Low Middle Income Country
    Asian Pac J Cancer Prev 2017 08 27;18(8):2079-2082. Epub 2017 Aug 27.
    Shaukat Khanum Memorial Cancer Hospital and Research Center,Lahore, Pakistan.
    Objective: To determine the impact of the trial on surgeon practice patterns at our institution. Methodology: A comparison of patients undergoing surgery for early breast cancer before and after the implementation of the new guidelines was done. We adopted the new guidelines in April 2015. Read More

    Survival in Good Performance Malignant Pleural Mesothelioma Patients; Prognostic Factors and Predictors of Response
    Asian Pac J Cancer Prev 2017 08 27;18(8):2073-2078. Epub 2017 Aug 27.
    Surgical Oncology Department, National Cancer Institute, Cairo University, Egypt. Email:
    Purpose: Malignant pleural mesothelioma (MPM) has a poor prognosis in general. Here we sought to evaluate prognostic factors and predictors of response to chemotherapy in good performance (PS=0-I) patients. Methods: We retrospectively reviewed our database and enrolled patients with MPM who received platinum containing chemotherapy (2012-2014). Read More

    Synchronous and Metachronous Malignant Epithelial and Lymphoid Tumors: a Clinicopathologic Study of 10 Patients from a Major Tertiary Care Center in Pakistan
    Asian Pac J Cancer Prev 2017 08 27;18(8):2067-2072. Epub 2017 Aug 27.
    Case reports and case series documenting unfortunate patients with more than one malignant neoplasm are rare but well established. While majority of such patients have two malignancies, cases with three or even four malignant neoplasms in the same patient have been published in literature. A number of factors influencing carcinogenesis have been implicated in such cases including exposure to large amounts of radiation, chemotherapy for the original malignancy; prolonged history of heavy smoking and exposure to other environmental carcinogens; aging; and underlying genetic alterations. Read More

    Accuracy of Cervical Visual Inspection with Acetic Acid Guide for 4-Quadrant Random Cervical Biopsies by General Practitioners in Women with Abnormal Pap Smears
    Asian Pac J Cancer Prev 2017 08 27;18(8):2063-2066. Epub 2017 Aug 27.
    Lampang Hospital, Thailand.
    Objective: To study the performance of visual inspection with acetic acid plus 4-quadrant cervical biopsy (V4B) by general practitioners in detecting high grade cervical lesion, compared to highest histopathologic grade from the American Society for Colposcopy and Cervical Pathology American Society for Colposcopy and Cervical Pathology (ASCCP) 2013 work up guidelines. Materials and methods: Patients with abnormal cervical cytologic screening results suggesting low grade lesions underwent V4B by general practitioners followed by colposcopy on the same day bases on ASCCP 2013 guidelines. Those with Pap smears indicative of high grade lesions or cervical cancer were sent to V4B before confirmed diagnosis and and therapeutic excisional procedures. Read More

    Role of Multidetector Computed Tomography in Evaluation of Ovarian Lesions in Women Clinically Suspected of Malignancy
    Asian Pac J Cancer Prev 2017 08 27;18(8):2059-2062. Epub 2017 Aug 27.
    Dow Institute of Radiology, Dow University of Health Sciences, Karachi, Pakistan. Email: shaziamukhtar78@
    Objective: To determine the diagnostic accuracy of multidetector computed tomography (MDCT) in the evaluation of ovarian carcinoma using histopathology as the gold standard. Methods: This prospective cross-sectional study was conducted at Department of Radiology, Dow international medical college, DUHS, Karachi from December 2015 to April 2016. All patients of 30-60 years of age who were referred for CT a scan of the abdomen and pelvis with clinical suspicion of malignant ovarian cancer were included. Read More

    Association of C-myc and p53 Gene Expression and Polymorphisms with Hepatitis C (HCV) Chronic Infection, Cirrhosis and Hepatocellular Carcinoma (HCC) Stages in Egypt
    Asian Pac J Cancer Prev 2017 08 27;18(8):2049-2057. Epub 2017 Aug 27.
    Department of Nucleic Acid Research, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, Egypt. Email:
    The aim of this study is to investigate c-myc and p53 gene expression and polymorphisms in different stages of HCV infection,. Expression levels of c-myc and p53 were evaluated by RT-PCR and polymorphisms were determined by PCR-RFLP in 60 HCV patients classified into chronic infection, cirrhosis and HCC groups along with 30 controls. c-myc gene expression significant increased through the stages as compared to the control level (1. Read More

    Molecular Response to Imatinib and Its Correlation with mRNA Expression Levels of Imatinib Influx Transporter (OCT1) in Indian Chronic Myeloid Leukemia Patients
    Asian Pac J Cancer Prev 2017 08 27;18(8):2043-2048. Epub 2017 Aug 27.
    Department of Hematology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. Email:
    Background and objectives: Imatinib mesylate is approved for the treatment of Chronic Myeloid Leukemia (CML). About 20% of patients with CML do not respond to treatment with Imatinib either initially or because of acquired resistance. In addition to mutated BCR-ABL1 kinase, the organic cation transporter1 (OCT1, encoded by SLC22A1) has been considered to contribute to Imatinib resistance in patients with chronic myeloid leukemia (CML). Read More

    Clinicopathologic Findings and Treatment Outcome of Laryngectomized Patients with Laryngeal Cancer and Hypopharyngeal Cancer: An Experience in Thailand
    Asian Pac J Cancer Prev 2017 08 27;18(8):2035-2042. Epub 2017 Aug 27.
    Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. E-mail:
    Objective: To evaluate the clinicopathologic findings and treatment outcome in laryngectomized patients with laryngeal cancer and hypopharyngeal cancer. Materials and Methods: The authors retrospectively reviewed the medical records of 212 patients who had been newly diagnosed and treated with laryngectomy between January 2000 and December 2010. The age, gender, clinical manifestations, associated predisposing condition, tumor WHO grade, AJCC tumor stage, maximum tumor size, anatomical involvement, type of surgery, postoperative sequelae, treatment and therapeutic outcome were analyzed. Read More

    Systematic Review of Hospital Based Cancer Registries (HBCRs): Necessary Tool to Improve Quality of Care in Cancer Patients
    Asian Pac J Cancer Prev 2017 08 27;18(8):2027-2033. Epub 2017 Aug 27.
    Health Information Management Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran. Email:
    Introduction: Incidence and mortality rate of cancer is increasing in all countries including low and middle-income countries. Hospital based cancer registry (HBCR) is an important tool for administration purpose and improvement of the quality of care. It is also important resource for population based cancer registries. Read More

    Current Trends in Management of Oral Mucositis in Cancer Treatment
    Asian Pac J Cancer Prev 2017 08 27;18(8):2019-2026. Epub 2017 Aug 27.
    Department of Preventive Oncology, Dr. B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India.
    Oral Mucositis (OM) is among the most common and dreaded toxicities of cancer therapy. It occurs in almost all patients who receive radiation therapy in which areas of oral and oropharyngeal mucosa are included in the treatment field. With the advent of chemotherapy in 1940 and its extended clinical legacy, it is only within the past two decade or so that mucositis’ complex pathobiology has become fully appreciated. Read More

    The Cost-Effectiveness of Quadrivalent Human Papillomavirus Vaccination in Indonesia
    Asian Pac J Cancer Prev 2017 07 27;18(7):2011-2017. Epub 2017 Jul 27.
    Indonesian Technical Advisory Group on Immunization (ITAGI), Indonesia. Email:
    Objective: National cervical cancer prevention program has been initiated in Indonesia since April 2015 and the ministry of health has started efforts to integrate the HPV Vaccine in the national immunization program since Q4 2015. Thus, it becomes important to analyze the cost-effectiveness of HPV vaccine. The objective of this model is to examine the potential long-term epidemiologic and economic impact of quadrivalent HPV(qHPV;6/11/16/18) vaccination program in Indonesia. Read More

    Combination Therapy with Low Copper Diet, Penicillamine and Gamma Knife Radiosurgery Reduces VEGF and IL-8 In Patients with Recurrent Glioblastoma
    Asian Pac J Cancer Prev 2017 07 27;18(7):1999-2003. Epub 2017 Jul 27.
    Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
    Purpose: Vascular Endothelial Growth Factor (VEGF) and interleukin-8 (IL-8) appear important in tumor growth. In this study, we have investigated the effect of copper reduction along with gamma knife radiosurgery on IL-8 and VEGF in patients with recurrent glioblastoma multiforme (GBM). Materials and Methods: In a 3-month randomized clinical trial, patients with recurrent GBM were allocated randomly between intervention and placebo groups. Read More

    Factors Affecting Mental Patients’ Behaviors and Attitudes Regarding Smoking
    Asian Pac J Cancer Prev 2017 07 27;18(7):1991-1997. Epub 2017 Jul 27.
    Director of Nursing, General Hospital, Asklipieion Voulas, Greece. Email:
    Background: Patients with mental health problems are in high risk to develop addiction, since smoking incidence is three times higher than that of the general population. The aim of the study was to investigate the factors affecting mental health patients’ smoking habits. Methods: The sample of study were 356 patients out of 403 initially approached, with 142 hospitalized in hospital facilities and 214 in community settings. Read More

    Impact of Cancer Awareness Drive on Generating Understanding and Improving Screening Practices for Breast Cancer: a Study on College Teachers in India
    Asian Pac J Cancer Prev 2017 07 27;18(7):1985-1990. Epub 2017 Jul 27.
    Department of Preventive Oncology, Dr. B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences (AIIMS), Delhi, India.
    Background: Breast cancer is the most common cancer among women in India and most present at advanced stage. Although early detection is the only way to reduce morbidity and mortality, people have a very low awareness about breast cancer signs and symptoms and screening practices. The purpose of this study was to assess the level of awareness and impact of awareness programs in adoption of safe practices in prevention and early detection. Read More

    Awareness of Breast Cancer among Female Care Givers in Tertiary Cancer Hospital, China
    Asian Pac J Cancer Prev 2017 07 27;18(7):1977-1983. Epub 2017 Jul 27.
    Xiang Ya School of Nursing, Central South University, China. Email:
    Objective: Breast cancer is a worldwide public health issue and most common cancer diagnosed among women including China, where advanced stages at diagnosis appears to be increasing and an ever-rising incidence twice as fast as global rates. The study was conducted to describe the awareness of breast cancer and associated factors among care giver women in tertiary Cancer Hospital, China. Methods: Institutional based cross-sectional study was conducted among 261 women selected by systematic random sampling. Read More

    Human Papillomavirus (HPV) Genotype Distribution in Patients with Recurrent Respiratory Papillomatosis (RRP) in Iran
    Asian Pac J Cancer Prev 2017 07 27;18(7):1973-1976. Epub 2017 Jul 27.
    Department of Microbiology, Faculty of Basic Science, Karaj branch, Islamic Azad University, Alborz, Iran.
    Background: Currently, recurrent respiratory papillomatosis (RRP), common laryngeal warts in the upper airway systems of children and adults are on the increase. Human papillomaviruses (HPVs) are suspected as causative agents. This study concerned HPV incidence and genotype distribution in Iranian RRP patients. Read More

    Influence of Training about Carcinogenic Effects of Hookah Smoking on the Awareness, Attitude, and Performance of Women
    Asian Pac J Cancer Prev 2017 07 27;18(7):1967-1971. Epub 2017 Jul 27.
    Master of Nursing, Salman Farsi Hospital-Bushehr, Social Security Organization, Bushehr, Iran.
    Background: Wrong attitudes and beliefs about the less carcinogenic effects of hookah smoking comparing to cigarette, easy availability, low cost, and other factors have caused that the usage of hookah smoking increase a lot in our country. Objective: This study has been done with the purpose of examining the influence of education about carcinogenic effects of hookah smoking on the awareness, attitude, and performance of women who refer to the healthcare and medical treatment centers. Materials and Methods: At this semi experimental study, 60 women who refer to the medical and hygienic centers of Bushehr were placed in 3 educational groups based on simple accidental sampling. Read More

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