166,422 results match your criteria Asian Pacific journal of cancer prevention : APJCP[Journal]


A plastid phylogeny of the fern genus Arachniodes (Dryopteridaceae).

Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.

CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, P.O. Box 416, Chengdu, Sichuan 610041, China; Missouri Botanical Garden,4344 Shaw Blvd., St. Louis, Missouri 63110, U.S.A. Electronic address:

Arachniodes (Dryopteridaceae) is one of the most confusing and controversial fern genera in terms of its circumscription, nomenclature, and taxonomy. Estimates of species number range from 40 to 200. Previous molecular works included only 2-17 accessions representing 2-12 species of Arachniodes and allied genera, leaving most of the Asian species remain unsampled and the infragneric relationships unclear. Read More

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December 2018

Predictor of Slower Gastric Emptying in Gastroesophageal Reflux Disease-Survey of An Asian-Pacific Cohort.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Asian populations have relatively lower prevalence of gastroesophageal reflux disease and tend to exhibit symptoms of prolonged gastric retention. However, it remains unknown if slower gastric empting influences its features in Asian countries.

Aim: We prospectively assessed the potential implications of slower gastric emptying in an Asian-Pacific cohort of gastroesophageal reflux disease by a hospital-based survey. Read More

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December 2018

Predictable Electronic Tuning By Choice of Azine Substituent in Five Iron(II) Triazoles: Redox Properties and DFT Calculations.

Chem Asian J 2018 Dec 14. Epub 2018 Dec 14.

University of Otago, Chemistry, Union Place West, 9054, Dunedin , NEW ZEALAND.

Five new mononuclear iron(II) tris-ligand complexes, and four solvatomorphs, have been made from the azine-substituted 1,2,4-triazole ligands (Lazine): [FeII(Lpyridazine)3](BF4)2 (1), [FeII(Lpyrazine)3](BF4)2 (2), [FeII(Lpyridine)3](BF4)2 (3), [FeII(L2pyrimidine)3](BF4)2 (4), and [FeII(L4pyrimidine)3](BF4)2 (5). Single-crystal XRD and solid-state magnetometry reveal that all of them are low spin (LS) Fe(II), except for solvatomorph 5·4H2O. Evans method NMR studies in CD2Cl2, (CD3)2CO and CD3CN show that all are LS in these solvents, except 5 in CD2Cl2 (consistent with L4pyrimidine imposing the weakest field). Read More

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December 2018

Evolutionary analysis of the Chikungunya virus epidemic in Mexico reveals intra-host mutational hotspots in the E1 protein.

PLoS One 2018 14;13(12):e0209292. Epub 2018 Dec 14.

División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

The epidemic potential of Chikungunya virus (CHIKV) was recently made evident by its introduction and rapid expansion in the Caribbean and the Americas. We sought to gain a detailed understanding of the dynamics of the epidemic in Mexico, the country with the highest number of confirmed CHIKV cases in the Americas, and to characterise viral evolution at the population and intra-host level. Analysis of the spatiotemporal distribution of 2,739 diagnosed cases in Mexico from December 2014 to December 2015 showed a rapid nationwide expansion of the epidemic with focalisation in the South West of the country. Read More

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December 2018

DRUSEN SUBTYPES AND CHOROIDAL CHARACTERISTICS IN ASIAN EYES WITH TYPICAL NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Retina 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Eye and ENT Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea.

Purpose: To investigate the prevalence of pachydrusen, soft drusen, and subretinal drusenoid deposits in eyes with different neovascular age-related macular degeneration (nAMD) subtypes, determine the relationship between each drusen type and the choroidal thickness, and analyze the distinct features of each nAMD subtype according to the drusen type.

Methods: Medical records involving 454 eyes from 454 patients with nAMD were retrospectively reviewed. The prevalence of each drusen type and the choroidal thickness and choroidal characteristics were evaluated according to the nAMD subtype. Read More

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December 2018
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Effect of Macrolide Prophylactic Therapy on AIDS-Defining Conditions and HIV-Associated Mortality.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Research Institute for Tropical Medicine, Muntinlupa City, Philippines.

Background: Mycobacterium avium complex (MAC) prophylaxis is recommended for patients with advanced HIV infection. With the decrease in incidence of disseminated MAC infection and the availability of antiretroviral therapy (ART), the benefits of macrolide prophylaxis were investigated. This study examined the impact of macrolide prophylaxis on AIDS-defining conditions and HIV-associated mortality in a cohort of HIV-infected patients on ART. Read More

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December 2018

Association Between the Polymorphism in miR-605 and Cancer Susceptibility: a PRISMA-Compliant Meta-Analysis.

Clin Lab 2018 Oct;64(11)

Background: MicroRNAs (miRNAs) play important roles in cancer development. miR-605 was reported in several studies and showed potential as a prognostic biomarker. However, the association between miR-605 and the risk of cancer remained controversial in previous studies. Read More

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October 2018

Novel Calix[4]arene-based Bis-Nitric Oxide Complexes: Synthesis, Physical Properties and Structural Characterization.

Chem Asian J 2018 Dec 14. Epub 2018 Dec 14.

Marquette University, Chemistry, 535 N 14th St, 53233, Milwaukee, UNITED STATES.

Calix[4]arene-based molecules have proven to be excellent candidates for nitric oxide (NO) sensors and storage materials due to their unprecedented binding affinity for NO. However, the structure of calix[4]arene is complicated by the presence of four possible conformers: 1,3-alternate, 1,2-alternate, cone and partial cone (paco). While prior studies have established the structure of the complexes of NO with several of these conformers, the 1,2-alternate conformer complex, i. Read More

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December 2018

Luminescent Solar Concentrators Based on Renewable Polyester Matrices.

Chem Asian J 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124, Pisa, Italy.

This study reports for the first time the use of bio-based alternatives for PMMA as host matrix for luminescent solar concentrators (LSCs). Notably, two types of renewable polyesters were synthesized in varying molar ratios via a two-step melt-polycondensation reaction with dibutyl tin oxide as catalyst. The first is a homopolymer of diethyl 2,3:4,5-di-O-methylene galactarate (GxMe) and isosorbide (IGPn), and the second is a random copolymer of GxMe with 1,3-propanediol and dimethyl terephthalate (GTPn). Read More

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December 2018

Entecavir and peginterferon alfa-2a in adults with HBeAg-positive immune tolerant chronic hepatitis B virus infection.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

University of Michigan.

Background/aim: Monotherapy with interferon or nucleoside analog is generally not recommended during the immune tolerant (IT) phase of chronic hepatitis B virus (HBV) infection. Recognition that high HBV DNA levels are associated with hepatocellular carcinoma has increased interest in treating HBV in the IT phase. Small pediatric studies reported efficacy with combination nucleoside analog and interferon therapy. Read More

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December 2018

Indocyanine green-enhanced fluorescence-guided video-assisted axillary surgery for chronic lymphocele.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgical Oncology, Unit of Surgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.

Introduction: Lymphocele occurs frequently after regional lymph node dissection. Surgery with multiple lymphatic ligation represents the only reliable treatment for long-standing chronic lymphocele.

Materials And Surgical Technique: We report the case of a man with chronic axillary seroma after axillary lymphadenectomy for melanoma. Read More

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December 2018

Effective method of gallbladder retraction for single-incision laparoscopic cholecystectomy.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Introduction: Recently, single-incision laparoscopic cholecystectomy has been accepted as an alternative to conventional laparoscopic cholecystectomy. The aim of this study was to retrospectively evaluate the safety and feasibility of unique gallbladder retraction methods using an ENDOLOOP® (Ethicon, Tokyo, Japan) and Lapaherclosure™ (Hakko Medical, Tokyo, Japan).

Materials And Surgical Technique: From May 2013 to April 2015, 77 patients underwent single-incision laparoscopic cholecystectomy with this retraction technique. Read More

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December 2018

Combination of electrohydraulic lithotripsy and laparoscopy for gallbladder access in type III Mirizzi syndrome.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Division of Surgery, Gastroenterological Center, Medico Shunju Shiroyama Hospital, Osaka, Japan.

Introduction: A 50-year-old Japanese man presented with obstructive jaundice. We performed endoscopic retrograde biliary drainage before biliary decompression. CT showed a thickened gallbladder wall with low-density areas and a 35-mm gallstone; the stone was impacted in the gallbladder neck and cystic duct. Read More

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December 2018

Laparoscopic reversal of Hartmann's procedure: A single-center experience.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Morphology, Experimental Medicine and Surgery, Section of General and Thoracic Surgery, University of Ferrara, Ferrara, Italy.

Introduction: Laparoscopic reversal of Hartmann's procedure (LHR) is considered a technically complex major surgical procedure. We present a retrospective analysis of a single-institution experience that assesses the treatment patterns and outcomes of patients who underwent LHR.

Materials And Surgical Technique: The study involved patients who underwent LHR between January 2004 and December 2017. Read More

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December 2018

Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans.

Int J Rheum Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Aim: The aim of this study was to determine which mitochondrial DNA (mtDNA) haplogroup is associated with new development of knee osteoarthritis (OA).

Methods: Epidemiologic data and knee radiographs with the Kellgren-Lawrence (K/L) score of the Ansung cohort study were prospectively obtained from the 2nd (2005-2006) and 6th follow-up periods (2013-2014). The mtDNA was analyzed by multiplex mutagenetically separated polymerase chain reaction to determine Asian mtDNA haplogroups (M, G, D, D4, D5, M7, M8, M9, M10, N, A, N9, R, F and B). Read More

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December 2018

Standardization of surgical procedures for laparoscopic Spiegel lobectomy: A single-institutional experience.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.

Introduction: Surgical techniques for Spiegel lobectomy remain technically difficult because of its deep anatomical location. Laparoscopic Spiegel lobectomy has not yet been standardized or widely reported. In the current study, we introduce technical improvements, including the liver hanging maneuver, to laparoscopic Spiegel lobectomy. Read More

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December 2018

Single-incision laparoscopy-assisted gastric transposition combined with thoracoscopic esophagectomy for esophageal replacement.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatric Surgery, Ege University Faculty of Medicine, Izmir, Turkey.

Introduction: We present a novel approach to single-incision laparoscopy-assisted gastric transposition combined with thoracoscopic esophagectomy in a child with long-segment corrosive esophageal stricture (CES).

Materials And Surgical Technique: A 2.5-year-old boy with a history of caustic ingestion underwent periodic esophageal dilatations at 3-week intervals, four sessions of topical mitomycin C application, and a strict antacid/H antagonist therapy for 8 months. Read More

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December 2018

Fruitful first experience with an 8K ultra-high-definition endoscope for laparoscopic colorectal surgery.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Gastrointestinal Surgery, St. Luke's International Hospital, Tokyo, Japan.

We performed laparoscopic surgery for three cases of colorectal cancer using an 8K ultra-high-definition endoscopic system, which offers 16-fold higher resolution than the current 2K high-definition endoscope. The weight of the camera has been successfully reduced to 370 g. To maximize the advantages of the 8K ultra-high-definition endoscope, surgery was performed by darkening the room and placing a large 85-in. Read More

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December 2018

Safe and easy technique for the laparoscopic application of Seprafilm® in gynecologic surgery.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.

Introduction: Laparoscopic surgery is a minimally invasive surgery, and the rate of postoperative adhesions is low. Although Seprafilm® helps to reduce adhesions, its application in the abdominal cavity during laparoscopic surgery is difficult because of its material. Therefore, we propose an easy method for applying this adhesion barrier. Read More

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December 2018

Synchrotron X-ray imaging of a dichasium cupule of Castanopsis from Eocene Baltic amber.

Am J Bot 2018 Dec 13. Epub 2018 Dec 13.

Department of Palaeobiology, Swedish Museum of Natural History, Box 50007, 10405, Stockholm, Sweden.

Premise Of The Study: The Eocene Baltic amber deposit represents the largest accumulation of fossil resin worldwide, and hundreds of thousands of entrapped arthropods have been recovered. Although Baltic amber preserves delicate plant structures in high fidelity, angiosperms of the "Baltic amber forest" remain poorly studied. We describe a pistillate partial inflorescence of Castanopsis (Fagaceae), expanding the knowledge of Fagaceae diversity from Baltic amber. Read More

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December 2018

Synthesis, Photophysical Properties and Two Photon Absorption Study of Tetraazachrysene-based N-heteroacenes.

Authors:
Qichun Zhang

Chem Asian J 2018 Dec 13. Epub 2018 Dec 13.

Nanyang Technological University, MSE, 50 Nanyang Ave, 639672, Singapore, SINGAPORE.

Three novel N-heteroacene molecules (SDNU-1, SDNU-2 and SDNU-3) based on tetraazachrysene units as cores have been designed, synthesized and fully characterized. Their photophysical, electrochemical and fluorescence properties were investigated, and they exhibited blue to green emission in solid state. Interestingly, SDNU-2 exhibited high solid photoluminescence quantum efficiencies (75. Read More

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December 2018

Back to the Roots … and the Future!

Chem Asian J 2018 Dec 13. Epub 2018 Dec 13.

Chemistry - An Asian Journal, Weinheim, Germany.

Taking stock: Editor-in-Chief Theresa Kueckmann reflects on the roots of Chemistry - An Asian Journal and lays out how these connect to the plans ahead. Read More

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December 2018

Far-Red/Near-Infrared Emissive (1,3-Dimethyl)barbituric Acid-Based AIEgens for High-Contrast Detection of Metastatic Tumors in Lung.

Chem Asian J 2018 Dec 13. Epub 2018 Dec 13.

Nankai University, College of Life Sciences, 94 Weijin Road, 300071, Tianjin, CHINA.

Despite of the enthusiastic research in aggregation-induced emission luminogens (AIEgens) in recent years, the ones that can be smoothly used for sophisticated biomedical applications such as in vivo bioimaging of pulmonary metastatic tumors during surgery are still limited. Herein, we report the design and synthesis of a new series of far-red/near-infrared (FR/NIR) fluorescent AIEgens that consist of methoxy-substituted tetraphenylethene (TPE) as the electron-donating moiety, (1,3-dimethyl)barbituric acid as the electron-withdrawing moiety, and different π-bridge units. As compared to benzene or 3,4-ethylenedioxythiophene, using thiophene as the π-conjugation unit between the donor and acceptor results in relatively higher absolute fluorescence quantum yield (14. Read More

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December 2018

Diet and Physical Activity of Korean Female Adolescents in Their Peer Networks.

J Nurs Scholarsh 2018 Dec 13. Epub 2018 Dec 13.

The University of Iowa, College of Nursing, Iowa City, IA, USA.

Purpose: The purpose of this study was to examine and compare the diet and physical activity behaviors of female adolescents and their friends within classroom-based peer networks in Korea.

Design: Complete social network analysis was used to examine the influence of classroom-based peers on adolescents' diets and physical activity. Data were collected by self-report from 99 female adolescents in three classrooms. Read More

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December 2018
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Pediatric tinea capitis caused by Trichophyton violaceum and Trichophyton soudanense in Rochester, Minnesota, United States.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Background: Tinea capitis is a common pediatric dermatophyte infection. Its main pathogen in the United States is Trichophyton tonsurans accounting for greater than 95% of the infections. Other pathogens including Trichophyton violaceum and Trichophyton soudanense are common in Africa. Read More

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December 2018

(Poly)terephthalates with Efficient Blue Emission in the Solid State.

Chem Asian J 2018 Dec 12. Epub 2018 Dec 12.

JAPAN.

We prepared dimethyl and diaryl 2,5-dialkoxytere-phthalates from dimethyl 2,5-dihydroxyterephthalate in good-to-high yields via alkylation or a sequence of alkylation, hydrolysis, chlorination, and condensation. The absorption spectra of the dialkoxyterephthalates contain a small band at 332-355 nm, which could be assigned to intramolecular charge-transfer transition from the alkoxy to alkoxycarbonyl groups on the basis of theoretical calculations using density functional theory. The dialkoxyterephthalates exhibited blue fluorescence with moderate-to-excellent quantum yields not only in solution but also in the solid state, such as a poly(methyl methacrylate) (PMMA) film and a powder. Read More

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December 2018

A Polystyrene-Cross-Linking Tricyclohexylphosphine: Synthesis, Characterization and Applications to Pd-Catalyzed Cross-Coupling Reactions of Aryl Chlorides.

Chem Asian J 2018 Dec 12. Epub 2018 Dec 12.

JAPAN.

A polystyrene-cross-linking tricyclohexylphosphine (PS-TCP) was synthesized through radical emulsion polymerization of 4-t-butylstyrene as a monomer and tris(trans-4-styrylcyclohexyl)phosphine as a three-fold cross-linker. The PS-TCP showed enhanced ligand performance compared to the corresponding polystyrene-triphenylphosphine hybrid PS-TPP and tricyclohexylphosphine in Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig reactions of aryl chlorides. Read More

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December 2018

Useful technique for draining a large cystic tumor through the round ligament in laparoscopic left hemihepatectomy.

Asian J Endosc Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastroenterological Surgery, Fukuyama City Hospital, Fukuyama, Japan.

Introduction: Some cystic liver tumors are huge when the diagnosis is made or surgery is needed. Although reducing tumor size by preoperative aspiration or drainage of the contents of the cystic tumor is helpful for liver resection, such procedures have a risk of tumor dissemination.

Materials And Surgical Technique: After the round ligament was dissected, a 12-Fr drainage catheter was inserted into the tumor via the round ligament under ultrasonography. Read More

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December 2018

Clinical and molecular characteristics of bladder urothelial carcinoma subtypes.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

Department of Organization, General Hospital of Benxi Iron and Steel Co., Benxi, China.

Bladder urothelial carcinoma (BLCA) is a common malignancy with high heterogeneity. A reasonable molecular subtyping can facilitate biological study and personalized therapy of BLCA. In this study, unsupervised consensus clustering was used to acquire the molecular subtypes of BLCA based on messenger RNA (mRNA) and microRNA (miRNA) data. Read More

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December 2018
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Alkenylboronates: synthesis and applications.

Chem Asian J 2018 Dec 12. Epub 2018 Dec 12.

SPAIN.

Organoboron compounds have become one of the most versatile building blocks in organic synthesis due to their accesible and efficient conversion into many different functional groups. In particular, alkenylboronates have received much attention as very reactive substrates in Suzuki-Miyaura cross-coupling reactions. Accordingly, efforts towards the development of efficient methods to prepare this type of compounds are constant. Read More

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December 2018

Three Dimensional Structures of NiO Nanoporous/ZnO Nanoarray Film for Enhanced Electrochromic Performance.

Chem Asian J 2018 Dec 12. Epub 2018 Dec 12.

Nanjing University of Posts and Telecommunications, Institute of Advanced materials, 9 Wenyuan Road, 210023, Nanjing, CHINA.

An electrochromic device using the as-obtained NiO nanoporous/ZnO nanoarray working electrode was constructed and assembled. NiO nanoporous/ZnO nanoarray film with three dimensional structures was prepared on ITO glass substrate by a two-step route which combined chemical bath deposition method with hydrothermal method. NiO nanoporous/ZnO nanoarray electrode reveals noticeable improvement of electrochromism compared to unitary NiO nanoporous, including larger optical modulation (81%), higher coloration efficiency (78. Read More

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December 2018

Effects of co-exposure of lipopolysaccharide and β-glucan (Zymosan A) in exacerbating murine allergic asthma associated with Asian sand dust.

J Appl Toxicol 2018 Dec 12. Epub 2018 Dec 12.

Environmental Chemistry Division, National Institute for Environmental Studies, Ibaraki, 305-8506, Japan.

During the 2000s, Asian sand dust (ASD) was implicated in the increasing prevalence of respiratory disorders, including asthma. We previously demonstrated that a fungus from ASD aerosol exacerbated ovalbumin (OVA)-induced airways inflammation. Exposure to heat-inactivated ASD (H-ASD) and either Zymosan A (ZymA, containing β-glucan) or lipopolysaccharide (LPS) exacerbated allergic airways inflammation in a mouse model, but the effects of co-exposure of LPS and β-glucan are unclear. Read More

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December 2018

Aromatic and Antiaromatic Cyclophane-type Hexaphyrin Dimers.

Authors:
Atsuhiro Osuka

Chem Asian J 2018 Dec 11. Epub 2018 Dec 11.

Kyoto University, Graduate School of Science, Department of Chemistry, Kita-shirakawa Oiwake-cho, Sakyo-ku, 606-8502, Kyoto, JAPAN.

A peripherally strapped [28]hexaphyrin takes a rectangular conformation and exhibits antiaromatic character. A cyclophane-type dimer consisting of such [28]hexaphyrins was synthesized from hexakis(pentafluorophenyl) [26]hexaphyrin via SNAr reaction with allyl alcohol, one-pot intra- and intermolecular olefin metathesis under improved Hoveyda-Grubbs catalysis, and final reduction with NaBH4. The cyclophane-type structures of [26]- and [28]hexaphyrin dimers have been revealed by X-ray analysis. Read More

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December 2018

A facile synthesis of thiophene-annulated naphthalene diimide-based small-molecular acceptors via two-step C-H activation.

Chem Asian J 2018 Dec 11. Epub 2018 Dec 11.

JAPAN.

Thiophene-annulated naphthalene diimide (NTI)-based molecules have recently emerged as an important class of n-type electronic materials. However, their synthesis has predominantly been achieved by Stille or Suzuki coupling reactions despite the presence of a potential C-H bond in NTI. Additionally, the synthesis of NTI or more generally mono-functionalization of naphthalene diimide (NDI) starts with a cumbersome bromination that has low yield, unselectivity, and tedious purification. Read More

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December 2018

Electronic Modulation of Palladium in Metal Phosphide Nanoparticles for Chemo-Selective Reduction of Halogenated Nitrobenzenes.

Chem Asian J 2018 Dec 11. Epub 2018 Dec 11.

CHINA.

Tuning the electronic property of transition metal plays an important role in the selective catalysis. Herein, the control synthesis of (PdxNiy)-P nanoparticles is reported. The binding energy of Pd3d5/2 as a function of x/y ratio are well tunable from 335. Read More

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December 2018

Predictive value of oncogenic driver subtype, programmed death-1 ligand (PD-L1) score, and smoking status on the efficacy of PD-1/PD-L1 inhibitors in patients with oncogene-driven non-small cell lung cancer.

Cancer 2018 Dec 11. Epub 2018 Dec 11.

Division of Medical Oncology, University of Colorado, Aurora, Colorado.

Background: This multicenter, retrospective study explored the value of oncogene driver subtype, programmed death-1 ligand (PD-L1) status, and smoking status for predicting which patients with oncogene-driven non-small cell lung cancer (NSCLC) would benefit from treatment with programmed death-1 (PD-1)/PD-L1 inhibitors.

Methods: The clinical features, PD-L1 tumor proportion scores, and PD-1/PD-L1 inhibitor (PDi) outcomes (objective response rate and progression-free survival) of patients who had advanced NSCLC with Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutations or common, actionable oncogenic drivers were captured.

Results: In total, 189 oncogene-positive patients were analyzed. Read More

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December 2018

Synthesis of Tetracoordinate Boron-Fused Benzoaceanthrylene Analogs via Tandem Electrophilic C-H Borylation.

Chem Asian J 2018 Dec 7. Epub 2018 Dec 7.

Kwansei Gakuin University, School of Science and Technology, Gakuen 2-1, 669-1337, Sanda, JAPAN.

Benzoaceanthrylene analogs with tetracoordinate boron at the ring junction were synthesized through tandem electrophilic C-H borylation of 2,6-dinaphthylpyridine followed by nucleophilic substitution. Notably, the [5,6]-annulation occurred selectively over [6,6]-annulation with the assistance of nitrogen coordination of the pyridine ring. The X-ray crystallographic analysis revealed the polycyclic skeleton with distorted tetracoordinate boron atom and the unique packing structure with intermolecular π-π interaction. Read More

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December 2018

Nanopore Confined Space for Single Molecule Analysis.

Chem Asian J 2018 Dec 10. Epub 2018 Dec 10.

East China University of Science and Technology, School of Chemistry & Molecular Engineering, 130 Meilong Road, 200237, Shanghai, CHINA.

Nanopore sensing is undergoing a booming era at single molecule level. The nanopores either composed from biological materials or fabricated from solid state substrates offer the unique pore forming confined space compatible to single molecule dimension. When experiencing an electric field, such single biomolecule interface reads single particle information, if fine-tuned, each molecule plays its typical ionic rhythm and will eventually compose the spectrum symphony. Read More

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December 2018

Hierarchical Nanotubes Constructed by Co S /MoS Ultrathin Nanosheets Wrapped with Reduced Graphene Oxide for Advanced Lithium Storage.

Chem Asian J 2018 Dec 10. Epub 2018 Dec 10.

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.

Nanostructured hybrid metal sulfides have attracted intensive attention due to their fascinating properties that are unattainable by the single-phased counterpart. Herein, we report an efficient approach to construct cobalt sulfide/molybdenum disulfide (Co S /MoS ) wrapped with reduced graphene oxide (rGO). The unique structures constructed by ultrathin nanosheets and synergetic effects benefitting from bimetallic sulfides provide improved lithium ions reaction kinetics, and they retain good structural integrity. Read More

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December 2018

Selection of Bacillus thuringiensis strains in citrus and their pathogenicity to Diaphorina citri (Hemiptera: Liviidae) nymphs.

Insect Sci 2018 Dec 10. Epub 2018 Dec 10.

Embrapa Mandioca e Fruticultura, 44380-000, Cruz das Almas, BA, Brazil.

Bacillus thuringiensis (Bt) toxins are effective in controlling insect pests either through the spraying of products or when expressed in transgenic crops. The discovery of endophytic Bt strains opened new perspectives for studies aimed at the control of sap-sucking insects, such as the Asian citrus psyllid Diaphorina citri Kuwayama (Hemiptera: Liviidae), a vector of 'Candidatus Liberibacter spp.', associated with citrus huanglongbing (HLB). Read More

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December 2018

Synthesis and Properties of Benzo-Fused Indeno[2,1-c]fluorenes.

Chem Asian J 2018 Dec 10. Epub 2018 Dec 10.

FRANCE.

A new set of fully-conjugated indenofluorenes has been synthesized and confirmed by solid-state structure analysis. The indeno[2,1-c]fluorenes and their benzo-fused analogues all contain the antiaromatic as-indacene core. The molecules possess high electron affinities and show a broad absorption that reaches into the near-IR region of the electromagnetic spectrum. Read More

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December 2018

Exploring Potential Energy Surfaces for Aggregation-Induced Emission - from Solution to Crystal.

Chem Asian J 2018 Dec 10. Epub 2018 Dec 10.

Beijing Institute of Technology, School of Chemistry and Chemical Engineering, South Zhongguancun Street 5, 100081, Beijing, CHINA.

Aggregation-induced emission (AIE) is a phenomenon where non-luminescent compounds in solution become strongly luminescent in aggregate and solid phase. It provides a fertile ground for luminescent applications that has rapidly developed in the last 15 years. In this review we centre on the contributions of theory and computations to understanding the molecular mechanism behind it. Read More

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December 2018

Factors affecting non-operative management of uncomplicated appendicitis in children: Should laparoscopic appendectomy be immediate, interval, or emergency?

Asian J Endosc Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan.

Introduction: We conducted a prospective non-randomized comparison of children with uncomplicated appendicitis treated either by primary laparoscopic appendectomy (PLA) or by non-operative management (NOM) followed by interval laparoscopic appendectomy (ILA) if NOM was successful or emergency laparoscopic appendectomy (ELA) if NOM was unsuccessful.

Methods: Before 2015, all patients with uncomplicated appendicitis underwent PLA using a standard three-port technique. Postoperatively, piperacillin/tazobactam was administered until the white blood cell count was less than 10 000/μL and patients were afebrile. Read More

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December 2018

Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry.

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

National Heart Centre Singapore, Singapore.

Aims: To examine sex differences in clinical characteristics, echocardiographic features, quality of life and 1-year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM).

Methods And Results: Utilizing the Asian Sudden Cardiac Death in HF (ASIAN-HF) registry, 5255 patients (mean age 59.6 ± 13. Read More

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December 2018

Prevalence and risk factors of gestational diabetes mellitus in Asia: a systematic review and meta-analysis.

BMC Pregnancy Childbirth 2018 Dec 14;18(1):494. Epub 2018 Dec 14.

Department of Pharmacy Practice, School of Pharmacy, International Medical University, 57000, Kuala Lumpur, Malaysia.

Background: Gestational diabetes mellitus (GDM) is a of the major public health issues in Asia. The present study aimed to determine the prevalence of, and risk factors for GDM in Asia via a systematic review and meta-analysis.

Methods: We systematically searched PubMed, Ovid, Scopus and ScienceDirect for observational studies in Asia from inception to August 2017. Read More

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December 2018

Dramatic response to low-dose rivaroxaban in an Asian patient with deep vein thrombosis and pulmonary embolism.

J Cardiol Cases 2013 Aug 7;8(2):e77-e80. Epub 2013 Jun 7.

Division of Cardiovascular Medicine, Toshiba General Hospital, Tokyo, Japan.

We report a case of deep venous thrombosis and pulmonary embolism treated with rivaroxaban due to warfarin allergy. The patient responded well to a low dose of 15 mg/day. There has been a report about treating patients with atrial fibrillation using a low dose of rivaroxaban in Japan, but no previous reports about deep vein thrombosis/pulmonary embolism. Read More

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A case of a patient with Takayasu arteritis treated with left subclavian artery stent implantation.

J Cardiol Cases 2015 Oct 8;12(4):123-125. Epub 2015 Jul 8.

Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea.

Takayasu arteritis is an uncommon chronic inflammatory arteritis affecting large vessels, predominantly the aorta and its main branches. This disease, primarily known to be frequent in Asia and Latin America region, occurs mainly in young people between the ages of 15 and 25 years, with a male to female ratio of 1:9. Here, we report a young Asian female patient with Takayasu arteritis affecting multiple arteries and treated with percutaneous transluminal angioplasty. Read More

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October 2015

Allelic variation of the dopamine receptor D4 gene polymorphic region in gibbons.

Primates 2000 Oct;41(4):383-392

National Institute of Animal Health, 3-1-1 Kannondai, 305-0856, Tsukuba, Ibaraki, Japan.

We examined the tandem repeat sequence of the dopamine receptor D4 (DRD4) gene in 73 individuals derived from 8 species of gibbons (genusHylobates) in an attempt to assess the variability of this gene in gibbon species.H. syndactylus (subgenusSymphalangus) andH. Read More

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October 2000

Allelic variation of the serotonin transporter gene polymorphic region in apes.

Primates 2000 Jul;41(3):267-273

National Institute of Animal Health, Kannondai, Tsukuba, 305-0856, Ibaraki, Japan.

To assess the change of serotonin transporter (5-HTT) gene-linked polymorphic region that has occurred during the process of hominization, we examined the allelic variation of 5-HTT gene-linked polymorphic region (5-HTTLPR) in anthropoid apes such as chimpanzees, gorillas, orang-utans, and gibbons, and determined the DNA sequences of the alleles in each species. All chimpanzees examined shared only the 17.5 repeat allele, while polymorphism was observed in the other apes and the 16 and 20 repeat alleles were most frequent in gorillas and orang-utans, respectively. Read More

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Mercury Contamination of Skin-whitening Creams in Phnom Penh, Cambodia.

J Health Pollut 2015 Dec 21;5(9):33-46. Epub 2015 Dec 21.

University of Wisconsin, Parkside, USA.

Background: In Cambodia, there is widespread use of skin-whitening creams containing levels of mercury that exceed Association of Southeast Asian Nations (ASEAN) guidelines by up to 35,000 times. Mercury in skin-whitening creams threatens to compromise the health of Cambodians.

Objectives: It is important to provide essential information on sources of mercury so that Cambodians can avoid exposure to elevated levels of mercury and to support informed management of consumer goods. Read More

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December 2015