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    9354 results match your criteria Asian Pacific journal of cancer prevention : APJCP[Journal]

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    Digital Cervicography by Simply Portable Device as an Alternative Test for Cervical Cancer Screening in Rural Area of Thailand
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1145-1149. Epub 2018 Apr 27.
    Obstetrician-Gynecologist, Bangmunnak Hospital, Phichit province, Thailand.
    Objective: Various screening methods for cervical cancer are proved to be effective in reducing such type of cancer. We aims to introduce a new portable device as an alternative method for cervical cancer screening. The performance of device was tested on the assessment of cervical lesions using cervicograph score with the cervical cytology. Read More

    Potential Impact of Vascular Endothelial Growth Factor Gene Variation (-2578C>A) on Breast Cancer Susceptibility in Saudi Arabia: a Case-Control Study
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1135-1143. Epub 2018 Apr 27.
    Department of Surgical Oncology, Faculty of Medicine, University of Tabuk, Kingdom of Saudi Arabia. Email:
    Aim: VEGF gene polymorphisms can induce either increase or inhibition of VEGF secretion, with altered promoter activity. The VEGF rs699947 SNP is located in the promoter region and is associated with susceptibility to breast carcinoma development. Here, we investigated the association of the -2578C>A polymorphism in the VEGF gene with breast cancer risk in Saudi women. Read More

    Inhibitory Effects of Arsenic Trioxide and Thalidomide on Angiogenesis and Vascular Endothelial Growth Factor Expression in Leukemia Cells
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1127-1134. Epub 2018 Apr 27.
    Hematology Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.Email:
    Acute myeloid leukemia (AML) is a blood disorder characterized by uncontrolled proliferation of myeloid progenitors and decrease in the apoptosis rate. The vascular endothelial growth factor (VEGF) promotes blood vessel regeneration which might play important roles in development and progression of neoplasia. Our previous studies focused on cytotoxicity and anticancer effects of arsenic trioxide (ATO) and thalidomide (THAL) as an anti-VEGF compound in the AML cell model. Read More

    Evaluating the Oncogenic and Tumor Suppressor Role of XPO5 in Different Tissue Tumor Types
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1119-1125. Epub 2018 Apr 27.
    Department of Physiology, Institute of Medical Sciences, Kohat, Pakistan. Email:
    The miRNAs nuclear export protein XPO5 has been previously studied in several individual malignancies. In our recent study we have demonstrated that excess levels of XPO5 enhanced the proliferation of prostate cancer cells. Similarly, there are studies to support the inhibitory role of XPO5 in cancers. Read More

    Prognostic Factors for Hormone Sensitive Metastatic Prostate Cancer: Impact of Disease Volume
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1113-1118. Epub 2018 Apr 27.
    Department of Clinical Oncology and Nuclear Medicine,Faculty of Medicine, Menoufia University, Egypt. Email:
    Background and Aim: The optimal management of metastatic hormone-sensitive prostate cancer has been controversial in recent years with introduction of upfront chemohormonal treatment based on results of several Western studies. This changing landscape has renewed interest in the concept “disease volume”, the focus of the present study is the Egyptian patients. Methods: Patients with hormone sensitive metastatic prostate cancer presenting at Menoufia University Hospital, Egypt, during the period from June 2013 to May 2016, were enrolled. Read More

    Knowledge, Perception, and Acceptance of HPV Vaccination and Screening for Cervical Cancer among Women in Yogyakarta Province, Indonesia
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1105-1111. Epub 2018 Apr 27.
    Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia. Email:
    Objective: To determine knowledge, perception, and acceptance related to cervical cancer, HPV vaccination and screening for cervical cancer among Indonesian women, particularly in Yogyakarta province. Methods: A convenience sample of 392 women consists of 192 young women, 100 mothers of girls aged 12 – 15 years, and 100 adult women in Yogyakarta province, Indonesia was participated in this study. A self-administered paper-based questionnaire was used to determine demographics characteristics of respondents, as well as their knowledge – perception – acceptance related to cervical cancer, HPV vaccination, and screening for cervical cancer. Read More

    Exploring Spatial Patterns of Colorectal Cancer in Tehran City, Iran
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1099-1104. Epub 2018 Apr 27.
    Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Email:
    Objectives: Colorectal cancer (CRC) may now be the second most common cancer in the world. The aim of this study was to determine whether clusters of high and low risk of CRC might exist at the neighborhood level in Tehran city. Methods: In this study, new cases of CRC provided from Cancer Registry Data of the Management Center of Ministry of Health and Medical Education of Iran in the period from March 2008 to March 2011 were analyzed. Read More

    Early Detection of Breast Cancer and Barrier to Screening Programmes amongst Thai Migrant Women in Australia: A Qualitative Study
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1089-1097. Epub 2018 Apr 27.
    Department of Public Health, Faculty of Health and Sports Science, Thaksin University, Phatthalung, Thailand. Email:
    Background: Breast cancer screening programme is seen as the best practice to detect breast cancer early. However, there are circumstances that can prevent immigrant women from attending screening programmes. Little is known about Thai migrants and the barriers to their seeking breast cancer screening when living in a new homeland. Read More

    Tobacco Cessation Scenarios Among Healthcare Profession Students: A Multidisciplinary Study
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1081-1088. Epub 2018 Apr 27.
    Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, India. Email:
    Background: It is acknowledged that the most effective means to contain the tobacco epidemic is to involve healthcare providers across various disciplines. The present study was undertaken to gain a comprehensive insight into various factors that determine the efficacy of multidisciplinary approaches in tobacco control. Methods: A cross sectional study design using a structured, pretested and self-administered questionnaire was employed in the present study, conducted among medical and dental interns and final year nursing students. Read More

    Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1075-1080. Epub 2018 Apr 27.
    Department of Oral Pathology and Microbiology, Desh Bhagat Dental College and Hospital, Mandigobindgarh, Punjab, India.Email:
    Objectives: Picrosirius red and MMP are capable of degrading extracellular matrix proteins, expressed in lesions such as squamous cell carcinomas. The present study was undertaken with an aim to analyze and compare changes in collagen using Picrosirius red staining under polarizing microscopy and immunohistochemical staining using anti MMP-13 in samples of oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. Materials and Methods: A total of 70 slides were prepared and divided into 3 groups. Read More

    Inverse Association between Glucose‒6‒Phosphate Dehydrogenase Deficiency and Hepatocellular Carcinoma
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1069-1073. Epub 2018 Apr 27.
    Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari 07100, Italy.
    Background: Studies in experimental models and humans suggest that glucose‒6‒phosphate dehydrogenase (G6PD) deficiency, an inherited condition, may be inversely related to hepatocellular carcinoma (HCC). We tested this hypothesis in a large cohort of Sardinian patients. Methods: A case-control study was performed using data from 11,143 records of patients who underwent upper endoscopy between 2002 and 2017. Read More

    Psychological Limbo as a Barrier to Spiritual Care for Parents of Children with Cancer: A Qualitative Study
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1063-1068. Epub 2018 Apr 27.
    Student Research Committee, Department of Nursing Management, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Email:
    Background: Pediatric cancer causes reduced life quality and psychological problems for parents. It is necessary to pay attention to spirituality, which plays a significant role in increasing the life quality of these parents and their patient children and managing the conditions associated with the disease. This study was performed to determine factors predisposing to spiritual care in parents of children suffering from cancer. Read More

    Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish Population
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1059-1062. Epub 2018 Apr 27.
    Department of Gastronomy and Culinary Arts Cumhuriyet University of Tourism Faculty, Sivas, Turkey. Email:
    Background: Breast cancer is a leading cause of death in women worldwide. Genetic polymorphisms have been reported to be important etiological factors. Murine double minute 2 (MDM2) T309G interacts with p53 and mutations in p53 are present in approximately 50% of all cancers. Read More

    Circulating MicroRNA-21 Expression as a Novel Serum Biomarker for Oral Sub-Mucous Fibrosis and Oral Squamous Cell Carcinoma
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1053-1057. Epub 2018 Apr 27.
    Department of Pathology, Era’s Lucknow Medical College and Hospital, Lucknow. Email:
    Background: Circulating miRNAs (miRs) in the biofluids such as serum and plasma act as potential biomarkers for early diagnosis, treatment and prognosis. In the present study, an attempt made to see the expression of miR-21 in serum of 20 cases of Oral sub-mucous fibrosis (OSMF), 20 cases of Oral squamous cell carcinoma and 40 healthy volunteers. The expression of miR-21 was evaluated in relation to different demographical and clinicopathological features such as sex, tobacco, pan-masala, alcohol, smoking and clinical staging respectively with an aim to identify correlation with oral pre-cancer and cancer stages. Read More

    Symptoms in Advanced Cancer Patients in a Greek Hospital: a Descriptive Study
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1047-1052. Epub 2018 Apr 27.
    Research Laboratory “Care in Adult Cancer Patients”, Department of Nursing, Alexander Technological Educational Institute, Thessaloniki, Sparta, Greece. Email:
    Background: Advanced cancer patients experience several physical or psychological symptoms which require palliative care for alleviation. Purpose: To assess the prevalence and intensity of symptoms among cancer patients receiving palliative care in a Greek hospital and to examine the association between reported symptoms and social clinical and demographic characteristics. Material-methods: This descriptive research was conducted during a sixmonth period using a convenient sample of 123 advanced cancer patients. Read More

    Prevalence, Cognitive and Socio-Demographic Determinants of Prostate Cancer Screening
    Asian Pac J Cancer Prev 2018 Apr 27;19(4):1041-1046. Epub 2018 Apr 27.
    Department of Public Health, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. Email:
    Screening may be effective for reducing deaths due to prostate cancer. The aim of this study was determine the prevalence and determinants influencing prostate cancer early detection behaviors based on the theory planned behavior (TPB). In this cross-sectional study, conducted in the west of Iran, a total of 250 men aged 50 to 70 years old were randomly selected to participate. Read More

    Association between Helicobacter pylori Infection and Cardiovascular Risk Factors among Patients in the Northern Part of Afghanistan: a Cross-Sectional Study in Andkhoy City
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):1035-1039. Epub 2018 Apr 25.
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Email:
    Background: The association between Helicobacter pylori infection and cardiovascular risk factors remains controversial. The high prevalence of H. pylori infection among Afghan patients warranted the investigation of this association. Read More

    Diagnostic Yield of Transbronchial Biopsy in Comparison to High Resolution Computerized Tomography in Sarcoidosis Cases
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):1029-1033. Epub 2018 Apr 25.
    Department of Pulmonary Medicine , Medical Faculty, Gazi University, Ankara, Turkey. Email: nkokturk©gmail.com
    This study aimed to evaluate the diagnostic yield of fiberoptic bronchoscopic (FOB) transbronchial biopsy and its relation with quantitative findings of high resolution computerized tomography (HRCT). A total of 83 patients, 19 males and 64 females with a mean age of 45.1 years diagnosed with sarcoidosis with complete records of high resolution computerized tomography were retrospectively recruited during the time period from Feb 2005 to Jan 2015. Read More

    Evaluation of Osteopontin as a Biomarker in Hepatocellular Carcinomas in Egyptian Patients with Chronic HCV Cirrhosis
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):1021-1027. Epub 2018 Apr 25.
    Theodore Bilharz Research Institute (TBRI), Cairo University,Giza, Egypt. Email:
    Background: Hepatocellular carcinoma (HCC) is a high incidence disease in Egypt with a poor prognosis and survival. Biomarkers are important for diagnosis of HCC at an early stage. Osteopontin (OPN), a glycoprotein secreted by macrophages, osteoblasts, and T cells, is also highly expressed in a variety of tumors, such as examples in the breast, colon, and stomach. Read More

    Assessing Breast Cancer Risk with an Artificial Neural Network
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):1017-1019. Epub 2018 Apr 25.
    Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Email:
    Objectives: Radiologists face uncertainty in making decisions based on their judgment of breast cancer risk. Artificial intelligence and machine learning techniques have been widely applied in detection/recognition of cancer. This study aimed to establish a model to aid radiologists in breast cancer risk estimation. Read More

    Expression of CDK6 in Oral Squamous Cell Carcinomas
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):1013-1016. Epub 2018 Apr 25.
    Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Email:
    Background: CDK6 is the key factor in regulation of the cell cycle and essential for passage into the G1 phase. It also plays an important role in the development of various tumors. In this cross-sectional study expression of the CDK6 protein in oral squamous cell carcinoma (OSCC) and healthy oral mucosa of controls was assessed to determine relations with malignant transformation and clinicopathologic factors. Read More

    Quality of Life of Nepalese Women Post Mastectomy
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):1005-1012. Epub 2018 Apr 25.
    HOPE School of Nursing, Zhongnan Hospital of Wuhan University, Wuhan, China.
    Introduction: Worldwide breast cancer is the common invasive cancer among the females. The quality of life of women after treatment, which is often a mastectomy, is frequently decreased. Objective: To determine the life quality of Nepalese women post mastectomy. Read More

    Determinants of Breast Cancer Screening by Mammography in Women Referred to Health Centers of Urmia, Iran
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):997-1003. Epub 2018 Apr 25.
    Reproductive Health Research Center,Urmia University of Medical Sciences, Urmia, Iran.
    Background: In women, breast cancer accounts for 30 percent of all cancers and it is the second leading cause of mortality. Mammography is considered an effective procedure to detect early breast cancer recommended by World Health Organization. This study was aimed to evaluate breast cancer screening determinants in women referred to health centers of Urmia for mammography in 2017. Read More

    Psychometric Properties of the Farsi Version of “Spiritual Needs Questionnaire” for Cancer Patients in Iran: A Methodological Study
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):989-995. Epub 2018 Apr 25.
    School of Nursing, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran. Email:
    Background and objectives: Spiritual needs are very important requirements to cancer patients. A valid and reliable instrument is needed for evaluation. This study was conducted to psychometrically evaluate a Spiritual Needs Questionnaire (SpNQ) for cancer patients in Iran. Read More

    The Impact of Perceived Barriers on Self-Efficacy for HPV Preventive Behavior
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):983-988. Epub 2018 Apr 25.
    College of Nursing, Chungnam National University, Daejeon, Republic of Korea. Email:
    Background: Cervical cancer is one of the most common cancers found among women. Many studies have focused on factors associated with human papilloma virus (HPV) preventive behavior and early detection using models such as the health belief model (HBM). Despite a growing body of knowledge regarding HPV preventive behavior, few studies have examined how self-efficacy affects this behavior in foreign women living in South Korea. Read More

    Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):977-982. Epub 2018 Apr 25.
    Department of Genetics, Faculty of Sciences, Islamic Azad University, Tabriz Branch,Tabriz, Iran. Email:
    Objective: To explore the possibility of a novel chemopreventive strategy for improving breast cancer treatment, the anticancer effects of a combination two natural compounds, Chrysin and Metformin, against T47D breast cancer cells were investigated. Materials and Methods: After treatment of T47D cells with Metformin, Chrysin and the two drugs in combination, toxicity to cancer cells was evaluated by MTT assay. Real time PCR was then used to determine the expression levels of hTERT and cyclin D1 genes. Read More

    Identification of Key Candidate Genes and Pathways in Endometrial Cancer by Integrated Bioinformatical Analysis
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):969-975. Epub 2018 Apr 25.
    Department of Gynecological Ward, The Third Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China.
    Endometrial Cancer is the most common female genital tract malignancy, its pathogenesis is complex, not yet fully described. To identify key genes of Endometrial Cancer we downloaded the gene chip GSE17025 from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified through the GEO2R analysis tool. Read More

    Metagenomics of Microbial Communities in Gallbladder Bile from Patients with Gallbladder Cancer or Cholelithiasis
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):961-967. Epub 2018 Apr 25.
    Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.Email:
    Salmonella typhi and Helicobacter infections have been shown to increase risk of gallbladder cancer (GBC), but findings have been inconsistent. Other bacterial infections may also be associated with GBC. However, information on microbial pathogens in gallbladder bile of GBC patients is scarce. Read More

    Proliferative Index (Ki67) for Prediction in Breast Duct Carcinomas
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):955-959. Epub 2018 Apr 25.
    MBChB, Msc, PhD mol. Pathology/UK, College of Medicine,Ninevah University, Iraq. Email:
    Background and objectives: To date, many tumor markers have been used to predict prognosis and therapeutic response in patients with breast cancer. The well established and routinely applied tumor markers are the estrogen-receptor, progesterone-receptor and Her2/neu-receptor. In the current study, we aimed to highlight any association of the proliferation index (Ki67) in breast infiltrative duct carcinoma with the tumor grade, tumor size and nodal status in addition to hormone receptor status. Read More

    Effecst of Patho- Biological Factors on the Survival of Recurrent Breast Cancer Cases
    Asian Pac J Cancer Prev 2018 04 25;19(4):949-953. Epub 2018 Apr 25.
    Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:
    Background: Recurrence of breast cancer after treatment is generally due to loco-regional invasion or distant metastasis. Although patients with metastasis are considered incurable, existing treatments might prolong a patient’s life while also improving its quality. Choice of approach for individual patients requires identification of relevant survival factors. Read More

    Contrast-Enhanced Perfusion MR Imaging to Differentiate Between Recurrent/Residual Brain Neoplasms and Radiation Necrosis
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):941-948. Epub 2018 Apr 25.
    Radiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Email:
    Purpose: To determine the value of dynamic susceptibility contrast enhanced (DSC) MRI (magnetic resonance imaging) perfusion in the characterization of newly developed/enlarging lesions within irradiated regions after treatment of brain tumors. Methods: This prospective cross-sectional study covered 23 patients, 12 females and 11 males. All cases initially presented with histologically proven malignant brain tumors and underwent surgical intervention followed by radiotherapy (+/- chemotherapy). Read More

    Comparative Cost-Effectiveness Analysis of Two Different Two-Dose Human Papillomavirus Vaccines in Malaysia
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):933-940. Epub 2018 Apr 25.
    GSK, Avenue Fleming 20, 1300 Wavre, Belgium. Email:
    Purpose: To comparatively evaluate the results of a 2-dose human papillomavirus (HPV) vaccination programme with the AS04-adjuvanted HPV16/18 vaccine (AS04-HPV-16/18v) or HPV-6/11/16/18 vaccine (4vHPVv), in addition to cervical cancer (CC) screening, in Malaysia. Methods: A lifetime Markov model replicating the natural history of HPV in 13-year-old girls was adapted to Malaysia to assess the impact of vaccination on pre-cancerous lesions, genital warts and CC cases, CC deaths, quality-adjusted life years (QALYs), and costs from the perspective of the Malaysian Ministry of Health. Vaccine effectiveness was based on efficacy and HPV type distribution. Read More

    Screening and Identification of Peptides Specifically Targeted to Gastric Cancer Cells from a Phage Display Peptide Library
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):927-932. Epub 2018 Apr 25.
    Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey. Email:
    Background: Gastric cancer is the second most common cancer among the malign cancer types. Inefficiency of traditional techniques both in diagnosis and therapy of the disease makes the development of alternative and novel techniques indispensable. As an alternative to traditional methods, tumor specific targeting small peptides can be used to increase the efficiency of the treatment and reduce the side effects related to traditional techniques. Read More

    Detection of a 4-bp Insertion/deletion Polymorphism within the Promoter of EGLN2 Using Mismatch PCR-RFLP and Its Association with Susceptibility to Breast Cancer
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):923-926. Epub 2018 Apr 25.
    Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Email:
    It has been shown that a 4-bp insertion/deletion (ins/del) polymorphism of EGLN2 influences the risk of several cancers. However, to date, no study has inspected the impact of the 4-bp ins/del polymorphism on breast cancer (BC) risk. A case-control study, including 134 breast cancer patients and 154 healthy women, was here conducted to examine the possible association between EGLN2 4-bp ins/del polymorphism and BC risk in a southeast Iranian population. Read More

    Clausenidin Induces Caspase 8-Dependent Apoptosis and Suppresses Production of VEGF in Liver Cancer Cells
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):917-922. Epub 2018 Apr 25.
    MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.
    Clausena excavata Burm f. is used by traditional healers to treat cancer patients in South East Asia. The use of the plant and its compounds is based on Asian folklore with little or no scientific evidence supporting the therapeutic efficacy The current study aimed to determine the effect of pure clausenidin isolated from C. Read More

    Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):913-916. Epub 2018 Apr 25.
    Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
    Introduction: The World Health Organization has categorized Helicobacter pylori as a carcinogen for gastric cancer, which causes human mortality worldwide. A number of studies have shown that H. pylori affects cell signaling in gastric epithelial cells and changes the expression of some proteins such as proinflammatory cytokines. Read More

    Impact of Mesenchymal Stem Cells and Vitamin D on Transforming Growth Factor Beta Signaling Pathway in Hepatocellular Carcinoma in Rats
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):905-912. Epub 2018 Apr 25.
    Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Email:
    Background: Transforming growth factor-beta (TGF-β) signaling is recognized as being critical for carcinogenesis. Vitamin D has proved to exert numerous tumor suppressive effects. Effects of bone marrow derived mesenchymal stem cells (BM-MSCs) on tumor progression are still controversial. Read More

    Serum CXCL12, but not CXCR4, Is Associated with Head and Neck Squamous Cell Carcinomas
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):901-904. Epub 2018 Apr 25.
    Oral and Dental Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Email:
    Background: Squamous cell carcinoma (SCC) is the most frequent malignancy of the head and neck (HN) region. We here evaluated associations of stromal cell derived factor-1 (SDF-1or CXCL12) and its receptor, CXCR4, with HNSCCs. Materials and Methods: Sixty newly diagnosed HNSCC patients were enrolled in the patient group, and 28 healthy individuals in the control group. Read More

    Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):897-899. Epub 2018 Apr 25.
    Department of Gynecology and obstetrics, Tehran University of Medical Sciences, Tehran, Iran. Email:
    Background: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. Methods: We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence. Read More

    Patient Reported Weight Loss Predicts Recurrence Rate in Renal Cell Cancer Cases after Nephrectomy
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):891-895. Epub 2018 Apr 25.
    Department of Medical Oncology, New Delhi-29, India.
    Background: Recurrence of renal cell cancer (RCC) affects approximately one-third of patients after curative nephrectomy. However, studies from the Indian subcontinent have been scarce. We here ddetermine relapse rates and patterns in an Indian cohort. Read More

    Association of BRCA1 Promoter Methylation with Breast Cancer in Asia: A Meta- Analysis
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):885-889. Epub 2018 Apr 25.
    Doctoral Program, Faculty of Medicine, Universitas Gadjah Mada, Indonesia. Email:
    Objective: The aim of this study was to determine the degree of association of BRCA1 promoter methylation with breast cancer in Asia. Methods: The study sample for the present meta-analysis was provided by published research articles on associations of BRCA1 promoter methylation with breast cancer in Asia accessed through databases on PubMed, ProQuest and EBSCO published between 1997 and November 2017. Pooled odds ratios (OR) were calculated with fixed and random-effect models. Read More

    Educational Interventions for Cervical Cancer Screening Behavior of Women: A Systematic Review
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):875-884. Epub 2018 Apr 25.
    Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: ac.ir
    Background: Cervical cancer is the second most common cancer in women worldwide; early detection can play a key role in reducing the associated morbidity. The objective of this study was to systematically assess the effects of educational interventions on cervical cancer screening (CCS) behavior of women. Methods: In this review the Cochrane library, Web of Science, Science Direct, PubMed, Scopus and search engine of Google scholar were searched for all interventional studies (trails, pre- and post-test or quasi-experimental) published in 2000-2017 for a systematic review, The search was based on the following keywords: cervix cancer, uterine cervical neoplasms, screening, prevention and control, Papanicolaou Test, pap test, pap smear, education, intervention, systematic review. Read More

    Parental Alcohol Drinking Habit as a Predictor of Alcohol Use among Secondary School Students in Barbados
    Asian Pac J Cancer Prev 2018 Apr 23;19(S1):57-62. Epub 2018 Apr 23.
    Department of General Studies and Behavioural Sciences, University of the Commonwealth Caribbean, Kingston, Jamaica. Email:
    Background: In Barbados and the wider Caribbean region, alcohol is widely consumed by adolescents and young people, including those in secondary schools. The high prevalence of alcohol use, and its potential adverse effects are a source of concern to policy makers and the general population, which calls for better understanding of the drivers of this problem. This study thus aimed at investigating whether parental alcohol drinking habit is a predictor of alcohol use among secondary school students in the country. Read More

    Alcohol Drinking among Primary School Children in Trinidad and Tobago: Prevalence and Associated Risk Factors
    Asian Pac J Cancer Prev 2018 Apr 23;19(S1):51-55. Epub 2018 Apr 23.
    School of Nursing, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston, Jamaica. Email:
    Background: Underage alcohol use is a pervasive problem with serious health, social and safety consequences. This study was undertaken to assess alcohol use by primary school children in Trinidad and Tobago, and to identify associated risk factors. Methods: We analysed data collected from 40 primary schools in Trinidad and Tobago by the National Alcohol and Drug Abuse Prevention Programme (NADAPP). Read More

    Investigating the Role of Alcohol in Behavioural Problems at School among Secondary School Students in Barbados
    Asian Pac J Cancer Prev 2018 Apr 23;19(S1):45-50. Epub 2018 Apr 23.
    Department of Community Health and Psychiatry, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston, Jamaica. Email:
    Background: The prevalence of alcohol use is quite high in the Caribbean region, and specifically, in Barbados. Alcohol use has been documented to negatively affect the way students behave within and outside school. This study set out to examine the role alcohol plays in students’ behavioural problems at school. Read More

    Risk Factors Associated with Frequent Alcohol Binge Drinking among Jamaicans: Does Gender Matter?
    Asian Pac J Cancer Prev 2018 Apr 23;19(S1):39-44. Epub 2018 Apr 23.
    Department of Community Health and Psychiatry, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston, Jamaica. Email:
    Objective: Alcohol is one of the most commonly consumed substances in Jamaica, despite the many health problems associated with excessive alcohol use. The aim of this study was to identify potential risk factors for alcohol binge drinking among Jamaicans, and determine if there were significant gender differences in the associations between identified risk factors and frequent binge drinking. Methods: Data collected from the 2016 National Household Survey Jamaica were analysed. Read More

    A Population-based Analysis of the Influence of Religious Affiliation on Alcohol Consumption among Jamaicans
    Asian Pac J Cancer Prev 2018 Apr 23;19(S1):33-37. Epub 2018 Apr 23.
    School of Nursing, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston, Jamaica. Email:
    Background: Religion sometimes shapes behaviours and experiences of its members including alcohol consumption. The aim of this study was to examine the possible influence of religious affiliation on alcohol consumption in Jamaica since they are predominantly Christians. Methods: Using a cross-sectional study design, we analysed data from National Household Survey 2,016 of 4,623 participants. Read More

    Are Adolescents likely to Start Smoking Early if Their Parents are Smokers? A Study of Jamaican High School Students
    Asian Pac J Cancer Prev 2018 Apr 23;19(S1):25-31. Epub 2018 Apr 23.
    School of Nursing, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston, Jamaica. Email:
    Background: The prevalence of cigarette smoking is high among adolescents in the Caribbean, including Jamaica. Age of initiation of cigarette smoking varies among adolescents. A number of factors has been reported to influence early age of initiation of cigarette smoking. Read More

    Single Parent Family Structure as a Predictor of Alcohol Use among Secondary School Students: Evidence from Jamaica
    Asian Pac J Cancer Prev 2018 Apr 23;19(S1):19-23. Epub 2018 Apr 23.
    Department of General Studies and Behavioural Sciences, University of the Commonwealth Caribbean, Kingston, Jamaica. Email:
    The aim of this study was to examine the potential relationship between Jamaican secondary students’ alcohol drinking habits and their family structure. Methods: Data collected from a nationally representative survey of 3,365 students were analysed. Descriptive and inferential statistics were performed. Read More

    Does Risk Perception Affect Alcohol Consumption among Secondary School Students in Jamaica?
    Asian Pac J Cancer Prev 2018 Apr 23;19(S1):13-18. Epub 2018 Apr 23.
    Department of General Studies and Behavioural Sciences, University of the Commonwealth Caribbean, Kingston, Jamaica. Email:
    Background: Alcohol consumption among young people is a major public health problem world-wide and in Jamaica. A number of factors have been reported to affect alcohol use among high school students. The aim of this study was to investigate the influence of perception of the harmfulness of alcohol on alcohol use among secondary school students in Jamaica. Read More

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