1,420 results match your criteria Asian Pacific journal of allergy and immunology[Journal]


A potential role of gliadin extract skin prick test in IgE-mediated wheat allergy.

Asian Pac J Allergy Immunol 2020 May 17. Epub 2020 May 17.

Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhonpathom, Thailand.

Background: Wheat extracts containing both water/salt and alcohol soluble proteins may increase extract's accuracy for diagnosing IgE-mediated wheat allergy.

Objective: This study aimed to determine the performance of new invented in-house prepared wheat extracts for skin prick test (SPT).

Methods: Children aged 1-18 years with history of immediate wheat allergy were recruited. Read More

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http://dx.doi.org/10.12932/AP-291119-0703DOI Listing

Clinical characteristics and immunological status of patients with 22q11.2 deletion syndrome in Northern Thailand.

Asian Pac J Allergy Immunol 2020 May 17. Epub 2020 May 17.

Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: 22q11.2 deletion syndrome is one of the most prevalent microdeletion syndromes in humans. The syndrome is characterized by extensive phenotypic variability. Read More

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http://dx.doi.org/10.12932/AP-241019-0671DOI Listing

Prevalence of rat and mouse sensitization in Asian patients with respiratory allergy.

Asian Pac J Allergy Immunol 2020 05 17. Epub 2020 May 17.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj hospital, Mahidol University, Bangkok, Thailand.

Background: Skin prick test (SPT) is useful in identifying rat and mouse sensitization.

Objective: To determine the prevalence of rat and mouse sensitization by using local and commercial allergen extracts.

Methods: Patients with allergic rhinitis or asthma were recruited. Read More

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http://dx.doi.org/10.12932/AP-231019-0667DOI Listing

Prenatal maternal anxiety promotes atopic dermatitis in offspring via placental DNA methylation changes.

Asian Pac J Allergy Immunol 2020 May 17. Epub 2020 May 17.

Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: Maternal anxiety during pregnancy has been previously reported to be associated with atopic dermatitis (AD) in offspring. The potential mechanism is not yet proven but epigenetic change may be suggested.

Objective: We examined whether maternal anxiety during pregnancy may alter placental DNA methylation, then develop AD in the offspring. Read More

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http://dx.doi.org/10.12932/AP-221119-0699DOI Listing

Effect of inhaled corticosteroids on bone mineral density in patients with asthma.

Asian Pac J Allergy Immunol 2020 May 17. Epub 2020 May 17.

Department of Respiratory Medicine and Clinical Immunology Dokkyo Medical University, Saitama Medical Center, Japan.

Background: Inhaled corticosteroids (ICS) are a safe treatment for asthma. However, at higher doses, ICS use has been reported to inhibit adrenocortical function.

Objective: This study aimed to evaluate the effect of ICS on bone mineral density (BMD) in adult patients with asthma. Read More

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http://dx.doi.org/10.12932/AP-191019-0663DOI Listing

Incidence of urticaria, angioedema, and type I hypersensitivity reactions associated with fibrinolytic agents in Thailand using the database of the health product vigilance center.

Asian Pac J Allergy Immunol 2020 May 17. Epub 2020 May 17.

Health Product Vigilance Center, Technical and Planning Division, Food and Drug Administration, Ministry of Public Health, Thailand.

Background: Besides hemorrhage, allergic reactions have also been observed in several clinical trials of fibrinolytic agents. These reactions might negatively affect patient outcomes, especially life-threatening type I hypersensitivity reactions such as anaphylaxis. However, there are limited data on the incidence of these reactions. Read More

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http://dx.doi.org/10.12932/AP-181119-0694DOI Listing

Outcomes of young children hospitalized with acute wheezing.

Asian Pac J Allergy Immunol 2020 May 17. Epub 2020 May 17.

Pediatric Allergy & Clinical Immunology Research Unit, Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand.

Background: Wheezing in preschool children is a common symptom.

Objective: The study aimed to determine an incidence of recurrent wheezing among young children who had been hospitalized with acute wheezing after 12 months. Factors associated with recurrent wheezing were explored. Read More

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http://dx.doi.org/10.12932/AP-061119-0687DOI Listing

Effect of moderate to severe atopic dermatitis on the prognosis of egg allergy resolution.

Asian Pac J Allergy Immunol 2020 Mar 29. Epub 2020 Mar 29.

Department of Pediatrics, Medical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea.

Background: Few studies have examined the effect of atopic dermatitis (AD) on the resolution of food allergies in Asia, and the predictors of egg allergy resolution are not yet well defined.

Objective: We evaluated whether AD severity could predict the resolution of egg allergy.

Methods: This retrospective cohort study included infants under 24 months of age diagnosed with IgE-mediated egg white allergy. Read More

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http://dx.doi.org/10.12932/AP-220719-0604DOI Listing

Characterization of children with IgE-mediated wheat allergy and risk factors that predict wheat anaphylaxis.

Asian Pac J Allergy Immunol 2020 Mar 29. Epub 2020 Mar 29.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: The number of children presenting with IgE-mediated wheat reactions to academic medical centers in Thailand continues to increase.

Objective: Improved knowledge about the clinical characteristic of wheat allergy is urgently needed to better understand the risk factors and to improve proper treatment in this patient population.

Methods: A cross-sectional study using questionnaire review of children who presented with IgE-mediated wheat allergy during 2001 to 2015 was performed. Read More

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http://dx.doi.org/10.12932/AP-130919-0645DOI Listing

The validity and reliability of the Thai-version of 5-D itch scale.

Asian Pac J Allergy Immunol 2020 Mar 29. Epub 2020 Mar 29.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Pruritus is commonly associated with skin disorders. The 5-D itch scale was developed as a specific questionnaire for pruritus.

Objective: This study aimed to evaluate the validity, reliability, and sensitivity to change of the Thai 5-D itch scale in Thai patients. Read More

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http://dx.doi.org/10.12932/AP-100120-0738DOI Listing

Serologic status and vaccine response against hepatitis B virus after allogeneic hematopoietic cell transplantation in pediatric patients.

Asian Pac J Allergy Immunol 2020 Mar 29. Epub 2020 Mar 29.

Department of Pediatrics, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea.

Background: Although vaccination against hepatitis B virus (HBV) is recommended for hematopoietic cell transplantation (HCT) recipients, previous studies evaluating serologic status and immunologic response to HBV vaccination in pediatric allogeneic HCT recipients are not enough.

Objective: This study aimed to evaluate serologic status against HBV and immunologic responses to HBV vaccination in children and adolescents receiving allogeneic HCTs.

Methods: Medical records of the enrolled 61 pediatric patients < 19 years of age who received their first allogeneic HCTs were retrospectively reviewed. Read More

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http://dx.doi.org/10.12932/AP-221219-0724DOI Listing

Efficacy and safety of omalizumab in patients with moderate-to-severe asthma: An analytic comparison of data from randomized controlled trials between Chinese and Caucasians.

Asian Pac J Allergy Immunol 2020 Mar 29. Epub 2020 Mar 29.

State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Background: Omalizumab has > 15 years of real-world evidence of effectiveness in Caucasian patients. In August 2017, it was approved as an add-on therapy for the management of moderate-to-severe asthma in China.

Objective: To compare the efficacy and safety of omalizumab in Chinese and Caucasian patients. Read More

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http://dx.doi.org/10.12932/AP-260819-0630DOI Listing
March 2020
1.255 Impact Factor

Pattern of allergic sensitization in chronic rhinitis: A 19-year retrospective study.

Asian Pac J Allergy Immunol 2020 Mar 29. Epub 2020 Mar 29.

Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: The pattern of allergic sensitization provides data for physicians to take appropriate care of allergic patients.

Objective: To analyze the long-term pattern of allergen skin prick test (SPT) sensitization at a single tertiary care hospital in Thailand.

Methods: Medical records of adult rhinitis patients during 1998 to 2017 were reviewed. Read More

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http://dx.doi.org/10.12932/AP-080719-0597DOI Listing

Erratum: Correction for affiliation of 3rd author Randomized comparison of caregivers' ability to use epinephrine autoinjectors and prefilled syringes for anaphylaxis.

Authors:

Asian Pac J Allergy Immunol 2020 03;38(1):67

Corrected affiliation of 3rd author Pediatric Allergy & Clinical Immunology Research Unit, Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand. Read More

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Determination of specific autoantibodies in patients with systemic lupus erythematosus by Line immunoassay, ELISA and CLIF assay.

Asian Pac J Allergy Immunol 2020 Mar 8. Epub 2020 Mar 8.

Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Detection of specific antinuclear-antibodies is very importance in term of diagnosis, prognosis and management of patients with systemic lupus erythematosus (SLE). To date, Line immunoassay (LIA), enzyme-linked immunosorbent assay (ELISA) and Crithidia luciliae indirect immunofluorescence (CLIF) assay are commonly used for detection of specific antinuclear-antibodies.

Objective: To determine the performance of LIA, ELISA and CLIF for the detection of anti-double-stranded DNA (dsDNA), anti-nucleosome, and anti-extractable nuclear antigens (ENA) antibodies in patients with SLE. Read More

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http://dx.doi.org/10.12932/AP-301019-0681DOI Listing

Worsening of chronic spontaneous urticaria after intake of hot pepper.

Asian Pac J Allergy Immunol 2020 Mar 8. Epub 2020 Mar 8.

Dermatological Allergology, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

Background: Patients with chronic spontaneous urticaria (CSU) have been reported to experience increased disease activity in response to the oral intake of hot pepper (Capsicum spp.). As of now, it is unclear how common this is. Read More

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http://dx.doi.org/10.12932/AP-280819-0632DOI Listing

An unequal endotoxin distribution in typical house types of Ho Chi Minh city.

Asian Pac J Allergy Immunol 2020 Mar 8. Epub 2020 Mar 8.

School of Public Health - Université Libre de Bruxelles (ULB), Brussels, Belgium.

Background: Endotoxin exposure may cause asthma exacerbations and contribute to non-atopic respiratory diseases. Viet Nam, a country with multiple house types, is lacking data on indoor contamination by endotoxin in regard with house types.

Objective: The comparison of measured settled dust endotoxin levels among house types in Ho Chi Minh city will allow to classify the house types regarding health risks. Read More

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http://dx.doi.org/10.12932/AP-280219-0503DOI Listing

Corticosteroid-induced drug reaction with eosinophilia and systematic symptoms successfully treated with a tumor necrosis factor alpha inhibitor.

Asian Pac J Allergy Immunol 2020 Mar 8. Epub 2020 Mar 8.

Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.

Background: Despite recent advances in the treatment of drug reaction with eosinophilia and systemic symptoms (DRESS), the mainstay of treatment involves discontinuing the culprit drugs and administering topical or systemic corticosteroid.

Objective: The clinical use of a tumor necrosis factor (TNF)-alpha inhibitor was rarely explored in treatment of DRESS.

Methods: We present a case of corticosteroid-induced DRESS that was successfully treated with a TNF-alpha inhibitor without sequalae. Read More

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http://dx.doi.org/10.12932/AP-210819-0628DOI Listing

Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19).

Asian Pac J Allergy Immunol 2020 Mar;38(1):10-18

Research unit for Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, Thailand.

Last decade witnessed the outbreak of many life-threatening human pathogens including Nipah, Ebola, Chikungunya, Zika, Middle East respiratory syndrome coronavirus (MERS-CoV), Severe Acute respiratory syndrome coronavirus (SARS-CoV) and more recently novel coronavirus (2019-nCoV or SARS-CoV-2). The disease condition associated with novel coronavirus, referred to as Coronavirus disease (COVID-19). The emergence of novel coronavirus in 2019 in Wuhan, China marked the third highly pathogenic coronavirus infecting humans in the 21st century. Read More

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http://dx.doi.org/10.12932/AP-200220-0773DOI Listing

The contribution of particulate matter to respiratory allergy.

Asian Pac J Allergy Immunol 2020 Mar;38(1):19-28

Interstitial Lung Disease Program, National Jewish Health, Denver, CO, United States.

Background: Air pollution contributes to an estimated six million deaths per year. Epidemiological and experimental studies show an association between air pollutant exposure and respiratory allergy.

Objective: We aimed to write a narrative review of the epidemiology of air pollution-related respiratory-related allergic disorders (including asthma and allergic rhinitis) and the effects of air pollutants - with an emphasis on the particulate matter - on respiratory allergy-related health. Read More

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http://dx.doi.org/10.12932/AP-100619-0579DOI Listing

Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic.

Asian Pac J Allergy Immunol 2020 Mar;38(1):1-9

Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS. The rapid genomic sequencing and open access data, together with advanced vaccine technology, are expected to give us more knowledge on the pathogen itself, including the host immune response as well as the plan for therapeutic vaccines in the near future. This review aims to provide a comparative view among SARS-CoV, MERS-CoV and the newly epidemic SARS-CoV-2, in the hope to gain a better understanding of the host-pathogen interaction, host immune responses, and the pathogen immune evasion strategies. Read More

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http://dx.doi.org/10.12932/AP-200220-0772DOI Listing

Clinical characteristics and outcomes of ocular allergy in Thai children.

Asian Pac J Allergy Immunol 2020 Feb 16. Epub 2020 Feb 16.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Allergic conjunctivitis (AC) is the most common ocular condition in allergic children. In tropical countries, the study about the clinical features and outcome of treatment is very limited.

Objective: To review clinical characteristics and outcomes of treatment in children with ocular allergy. Read More

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http://dx.doi.org/10.12932/AP-160519-0564DOI Listing
February 2020

Incidence and predictors of nevirapine and efavirenz-associated rash among Indonesian HIV patients.

Asian Pac J Allergy Immunol 2020 Feb 16. Epub 2020 Feb 16.

Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/CiptoMangunkusumo Hospital, Jakarta, Indonesia.

Background: Many drugs used for the treatment of HIV disease can cause drug hypersensitivity reactions. Since 2002, World Health Organization (WHO) has recommended the use of nevirapine and efavirenz as part of first line antiretroviral therapies for several years. Both of the drugs had equivalent clinical efficacy but differences in toxicity profile. Read More

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http://dx.doi.org/10.12932/AP-080719-0596DOI Listing
February 2020

Risk factors of uncontrolled symptoms using the standard dose of second-generation H1 -antihistamines in chronic spontaneous urticaria children.

Asian Pac J Allergy Immunol 2020 Feb 16. Epub 2020 Feb 16.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Background: A standard dose of second-generation H1 -antihistamines is recommended as the first-line treatment of chronic spontaneous urticaria (CSU), previous studies have found that approximately 20-50% of CSU children fail to control their symptoms and required step-up treatments.

Objective: To evaluate the predictors of uncontrolled symptoms with first-line medication and describe the treatment outcomes of CSU children in the southern region of Thailand.

Methods: This retrospective chart review of CSU patients, aged 2-18 years, who were initially treated with the standard dose of second-generation H1 -antihistamine at the Pediatric Allergy Clinic, Songkhlanagarind Hospital, from January 2008 to July 2018. Read More

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http://dx.doi.org/10.12932/AP-030619-0573DOI Listing
February 2020

Enzyme replacement therapy desensitization in a child with infantile onset Pompe disease.

Asian Pac J Allergy Immunol 2020 Feb 16. Epub 2020 Feb 16.

Allergy Service, Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore.

Background: Enzyme replacement therapy significantly reduces morbidity and mortality in patients with Pompe disease. Development of hypersensitivity reactions to enzyme replacement therapy is common and can adversely affect disease outcomes when treatment is halted or delayed.

Objective: Our institution reports a case of successful alglucosidase alfa enzyme replacement therapy desensitisation in a 9-year-old girl with infantile onset Pompe disease. Read More

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http://dx.doi.org/10.12932/AP-060919-0638DOI Listing
February 2020

Intermittent hypoxia in rat enhancing peritoneal membrane thickening through HIF-1α-induced cytokines in peritoneum.

Asian Pac J Allergy Immunol 2019 Dec 14. Epub 2019 Dec 14.

Center of Excellence in Kidney Metabolic Disorders.

Background: Due to the high prevalence of both obstructive sleep apnea syndrome (OSA) and end-stage renal disease (ESRD), the co-existence of both conditions in peritoneal dialysis is demonstrated. Because OSA-induced chronic intermittent hypoxia is well-known, the hypoxia might worsen peritoneal membrane.

Objective: We tested the influence of chronic intermittent hypoxia upon peritoneal membrane in a Sprague-Dawley rat model. Read More

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http://dx.doi.org/10.12932/AP-290519-0570DOI Listing
December 2019

Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.

Asian Pac J Allergy Immunol 2019 Dec 14. Epub 2019 Dec 14.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Acute urticaria is a common cutaneous disease encountered in children, while anaphylaxis can show cutaneous symptoms as well as systemic symptoms. One study found that urticaria tends to precede anaphylaxis, but studies on the different role of eosinophils and related cytokines in anaphylaxis and urticaria are lacking.

Objective: The aim of this study was to compare the clinical features, total eosinophil count, serum levels of interleukin (IL)-18, IL-18 binding protein (BP), IL-1 receptor-like (RL) 1, and IL-33 and compare with tryptase to examine if any differences could be found between patients who experienced anaphylaxis and urticaria. Read More

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http://dx.doi.org/10.12932/AP-270619-0588DOI Listing
December 2019

In case of recurrent wheezing and bronchiolitis: Think again, it may be a primary immunodeficiency.

Asian Pac J Allergy Immunol 2019 Dec 14. Epub 2019 Dec 14.

Section of Pediatric Immunology, Hacettepe University, Ihsan Dogramaci Children's Hospital, Ankara, Turkey.

Background: Wheezing, starting early in life, is a heterogeneous medical condition caused by airway obstruction due to different underlying mechanisms. Primary immunodeficiencies are also among the risk factors that cause wheezing and recurrent bronchiolitis. ADA deficiency is a primary immunodeficiency, also a rare metabolic disease associated with multisystemic clinical findings. Read More

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http://dx.doi.org/10.12932/AP-260719-0610DOI Listing
December 2019

Efficacy of a newly developed cartoon video on dry powder inhaler technique: a multicenter study.

Asian Pac J Allergy Immunol 2019 Dec 14. Epub 2019 Dec 14.

Department of Pediatrics, Prapokklao hospital, Chanthaburi, Thailand.

Background: One of the factors associated with uncontrolled pediatric asthma is inadequate delivery of inhaled medication to the lungs. Incorrect inhaler technique has been reported. We developed a 2-minute cartoon video instruction aiming to improve dry powder inhaler (DPI) technique. Read More

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http://dx.doi.org/10.12932/AP-240719-0607DOI Listing
December 2019

Dendritic cells as key players in systemic lupus erythematosus.

Asian Pac J Allergy Immunol 2019 Dec 14. Epub 2019 Dec 14.

Center of Excellence in Immunology and Immune-mediated Diseases, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330 Thailand.

System lupus erythematosus (SLE) is a chronic autoimmune disorder affecting multiple organs, and persistent disease activity is associated with increased morbidity and mortality. Impairment of immune cell function and loss of immune tolerance to self-antigens are significant determinants that trigger inflammation and drive SLE pathogenesis. Dendritic cells (DCs) are the most potent antigen-presenting cells that serve as a critical link between innate and adaptive immune system. Read More

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http://dx.doi.org/10.12932/AP-070919-0639DOI Listing
December 2019

Nonspecific interstitial pneumonia in refractory systemic juvenile idiopathic arthritis responded to tocilizumab treatment.

Asian Pac J Allergy Immunol 2019 Dec 14. Epub 2019 Dec 14.

Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Nonspecific interstitial pneumonia (NSIP) is a rare pulmonary complication in systemic juvenile idiopathic arthritis (SJIA).

Objective: To present a case with NSIP in SJIA METHODS: Case report RESULTS: We report the case of a 4-year-old boy with SJIA complicated by macrophage activation syndrome (MAS) refractory to conventional therapy, and who later developed NSIP confirmed by high-resolution computerized tomography of the chest and lung histopathology. The patient received tocilizumab, a monoclonal antibody to interleukin-6 receptor, to control his disease. Read More

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http://dx.doi.org/10.12932/AP-050819-0616DOI Listing
December 2019

Clinical characteristics and treatment response of chronic spontaneous urticaria according to age: A single-center Korean study.

Asian Pac J Allergy Immunol 2019 Dec 14. Epub 2019 Dec 14.

Department of Pediatrics, Medical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea.

Background: Little information exists regarding the incidence of chronic spontaneous urticaria (CSU) or differences in its characteristics according to age.

Objective: To evaluate the incidence, clinical characteristics and treatment response of CSU according to age.

Methods: The relevance of gender, age, history of allergic disease, pre-diagnosis duration, and treatment response were retrospectively evaluated in patients diagnosed with CSU at Pusan National University Hospital between 2011 and 2018. Read More

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http://dx.doi.org/10.12932/AP-050719-0594DOI Listing
December 2019

Effect of vitamin D on lung function assessed by forced oscillation technique in asthmatic children with vitamin D deficiency: A randomized double-blind placebo-controlled trial.

Asian Pac J Allergy Immunol 2019 Dec 14. Epub 2019 Dec 14.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: The role of vitamin D and asthma in pulmonary function changes showed conflicting result.

Objective: To evaluate if vitamin D treatment would improve lung function assessed by forced oscillation technique (FOT) in vitamin D deficient asthmatic children.

Methods: A randomized double-blind placebo-controlled trial was performed in children, aged 3-18 years with well controlled asthma. Read More

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http://dx.doi.org/10.12932/AP-010519-0553DOI Listing
December 2019

Evaluation of proteins in natural rubber latex gloves and pulmonary function amongst female nurses in two tertiary hospitals in southern, Thailand.

Asian Pac J Allergy Immunol 2019 Nov 3. Epub 2019 Nov 3.

Population Health Sciences, Bristol Medical School, University of Bristol, United Kingdom.

Background: Inhaled natural rubber latex (NRL) allergens in a healthcare environment can cause NRL sensitization and reduce pulmonary functions.

Objectives: To determine the amount of proteins and the effects of NRL gloves on the pulmonary functions of female nurses in two hospitals in the southern Thailand.

Methods: The study included 340 female nurses from two hospitals in which self-reported information and a blood sample were collected. Read More

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http://dx.doi.org/10.12932/AP-310319-053DOI Listing
November 2019

Successful haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide in a child with X-linked chronic granulomatous disease: A first report in Asia.

Asian Pac J Allergy Immunol 2019 Nov 3. Epub 2019 Nov 3.

Department of Pediatrics, Faculty of Medicine Ramathibodi hospital, Mahidol University, Ratchathewi, Bangkok, Thailand.

Backgound: HLA-matched hematopoietic stem cell transplantation (HSCT) is the curative treatment for chronic granulomatous disease (CGD).

Objective: To report a case of X-linked CGD with active infection successfully treated by haploidentical HSCT with post-transplant high dose cyclophosphamide (PTCY).

Methods: A 5-year-old Thai boy with CGD was undergone for haploidentical HSCT using PTCY with correction of the phagocytic function. Read More

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http://dx.doi.org/10.12932/AP-290419-0551DOI Listing
November 2019
1 Read
1.255 Impact Factor

Clinical characteristics and aspirin desensitization in Thai patients with a suggestive history of NSAID-exacerbated respiratory disease.

Asian Pac J Allergy Immunol 2019 Nov 3. Epub 2019 Nov 3.

Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is characterized by the triad of chronic rhinosinusitis with nasal polyp, asthma, and aspirin (ASA) or NSAID hypersensitivity. Previous study of NERD has rarely been reported in Asian population.

Objectives: To investigate the clinical characteristics and outcomes of aspirin desensitization (ASAD) in Thai NERD patients. Read More

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http://dx.doi.org/10.12932/AP-150619-0583DOI Listing
November 2019

A case of dengue fever presenting with acute urticaria.

Asian Pac J Allergy Immunol 2019 Nov 3. Epub 2019 Nov 3.

Dermatological Allergology, Department of Dermatology and Allergy, Charité - Universit?tsmedizin Berlin, Germany.

Background: Acute urticaria (AU) is characterized by the occurrence of spontaneous wheals, angioedema, or both for less than 6 weeks. Viral infection is considered to be one of the common causes of AU, however AU has never been reported in association with dengue infection.

Objective: To describe the first case of AU in dengue virus infection. Read More

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http://dx.doi.org/10.12932/AP-150419-0539DOI Listing
November 2019
1 Read

The prevalence of high risk of obstructive sleep apnea in patients with allergic rhinitis.

Asian Pac J Allergy Immunol 2019 Nov 3. Epub 2019 Nov 3.

Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Although allergic rhinitis (AR) has not been acknowledged as a strong risk factor for obstructive sleep apnea (OSA), several pathophysiological linkages between these two conditions have frequently been reported. However, epidemiological data relating to the prevalence of OSA in patients with AR remain scarce.

Objective: To investigate the prevalence of patients at high risk for OSA among patients with AR, and to determine the relationship between OSA and severity of AR. Read More

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http://dx.doi.org/10.12932/AP-141218-0458DOI Listing
November 2019

Prevalence of nasal carriage of Staphylococcus aureus in allergic rhinitis patients and healthy controls in Thailand.

Asian Pac J Allergy Immunol 2019 Nov 3. Epub 2019 Nov 3.

Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Staphylococcus aureus has been proposed as a disease modifier of allergic rhinitis (AR) severity. Although several studies have investigated the prevalence of nasal carriage of S. aureus in healthy controls and AR patients, data from Thailand is scarce. Read More

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http://dx.doi.org/10.12932/AP-080719-0598DOI Listing
November 2019

Diet supplementation with commercial enzymatically-hydrolyzed egg white peptides ameliorates the severity of allergy in a mouse model of egg white allergy.

Asian Pac J Allergy Immunol 2019 Nov 3. Epub 2019 Nov 3.

Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, 6-46, Ikebiraki-cho, Nishinomiya, Hyogo, 663-8558, Japan.

Background: Commercial spray-dried egg white (S-EW) is often used for oral immunotherapy (OIT). Peptifine® (PF), a commercial preparation of enzymatically-hydrolyzed egg white (EW) peptides, is considered safe OIT food.

Objective: Here, we examined the therapeutic effect of PF or S-EW in a mouse model of EW allergy. Read More

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http://dx.doi.org/10.12932/AP-080219-0489DOI Listing
November 2019

The association of plasma cytokines including VEGF with recurrent wheezing in allergic patients.

Asian Pac J Allergy Immunol 2019 Oct 6. Epub 2019 Oct 6.

Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, Korea.

Background: Various cytokines have been studied to determine their functions in the pathogenesis of allergic diseases and their potential as therapeutic targets, but the roles and clinical applicability of many of these cytokines still remain unclear.

Objective: We aimed to measure the plasma levels of eight cytokines known to be relevant to allergic diseases, and to determine their association with the diagnostic characteristics of allergic patients.

Methods: The levels of a panel of eight cytokines (IL-5, IL-10, IL12p70, Leptin, CXCL5/ENA-78, CCL2/MCP-1, PDGFBB, and VEGF) were measured in plasma obtained from 83 allergic patients. Read More

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http://dx.doi.org/10.12932/AP-070219-0488DOI Listing
October 2019
1 Read
1.255 Impact Factor

Prognostic significance of PD-L1 protein expression and copy number gains in locally advanced cervical cancer.

Asian Pac J Allergy Immunol 2019 Oct 6. Epub 2019 Oct 6.

Department of Anatomical Pathology, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok, 10300 Thailand.

Introduction: Although immune checkpoint inhibitors against programmed death-1 (PD-1) and its ligand (PD-L1) have demonstrated promising results in several solid malignancies, including cervical cancer, there are some limitations to using PD-L1 immunohistochemical expression as a predictive biomarker for selecting patients who may benefit from such therapy.

Objective: To examine the protein expression and genetic status of PD?L1 with clinical outcomes in locally advanced cer- vical cancer.

Methods: We investigated the PD-L1 gene copy number gains assessed by fluorescence in situ hybridization (FISH) and PD-L1 expression using immunohistochemistry in 123 patients with locally advanced cervical cancers between December 2008 and December 2016. Read More

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http://dx.doi.org/10.12932/AP-120419-0538DOI Listing
October 2019
21 Reads

Alteration of macrophage immune phenotype in a murine sepsis model is associated with susceptibility to secondary fungal infection.

Asian Pac J Allergy Immunol 2019 Oct 6. Epub 2019 Oct 6.

Department of Microbiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: Secondary fungal infection is a major complication in patients with sepsis-associated immunosuppression. However, sepsis-induced immune alterations related to fungal susceptibility have not been well characterized.

Objectives: To determine kinetic changes in the immune phenotype by determining the proportion of T cells, B cells and macrophages, and especially the expression of an immune exhaustion marker PD-1, in murine sepsis. Read More

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http://dx.doi.org/10.12932/AP-170519-0565DOI Listing
October 2019

Urticaria, angioedema, and type I hypersensitivity reactions associated with fibrinolytic agents.

Asian Pac J Allergy Immunol 2019 Oct 6. Epub 2019 Oct 6.

Cardiovascular Unit, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, Thailand.

Background: Several clinical trials of fibrinolytic agents have reported the occurrence of allergic reactions, in addition to hemorrhage. These reactions might worsen patient outcomes, especially by causing life-threatening type I hypersensitivity reactions, including anaphylaxis; however, there is a scarcity of data in this regard.

Objective: This study described and characterized patients with urticaria, angioedema and type I hypersensitivity reactions caused by fibrinolytic agents. Read More

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http://dx.doi.org/10.12932/AP-050619-0574DOI Listing
October 2019
1 Read

Effect of gene polymorphisms in ADAM33, TGFβ1, VEGFA, and PLAUR on asthma in Thai population.

Asian Pac J Allergy Immunol 2019 Oct 6. Epub 2019 Oct 6.

Division of Medical Genetics Research and Laboratory, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Most of the asthma susceptibility genes have demonstrated moderate effect. Gene-gene interaction may play a role in asthma.

Objective: To investigate the genetic and gene-gene interaction effects of single nucleotide polymorphisms (SNPs) in the ADAM33, TGFβ1, VEGFA, and PLAUR genes on asthma in Thai population. Read More

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http://dx.doi.org/10.12932/AP-010419-0532DOI Listing
October 2019
1 Read

Decrease of spleen invariant natural killer T and natural killer cell numbers in Burkholderia thailandensis-infected C57BL/6 mice.

Asian Pac J Allergy Immunol 2019 Oct 6. Epub 2019 Oct 6.

Department of Microbiology.

Background: Burkholderia thailandensis is a non-pathogenic bacterium that is closely related to B. pseudomallei. Invariant natural killer T (iNKT) cells are innate lymphoid cells that play a role in bacterial infections; however the iNKT cells in B. Read More

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http://dx.doi.org/10.12932/AP-070519-0556DOI Listing
October 2019
4 Reads

Clinical trials of Cry j 1 and Cry j 2 T-cell epitope peptide-expressing rice in patients with Japanese cedar pollinosis.

Asian Pac J Allergy Immunol 2019 Oct 6. Epub 2019 Oct 6.

Medical Affairs Bureau, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Habikino City, Osaka 583-8588, Japan.

Background: In allergic models, administration of rice that expresses a hybrid peptide consisting of 7 major T cell epitopes of Cry j 1 and Cry j 2 (7Crp), suppressed allergic symptoms, IgE elevation and specific T cell response to Japanese cedar pollen.

Objective: To evaluate the efficacy and safety of 7Crp-expressing rice in patients with Japanese cedar pollinosis METHODS: A 24-week randomized, double-blind, placebo-controlled study was performed to see the efficacy of 7Crp on allergic symptoms using scoring systems, in which 45 patients were assigned to take either 5 g, 20 g test rice, or placebo daily. A 96-week open study was also conducted to determine its inhibitory effect on serum IgE and T cell proliferative response for Japanese cedar pollen, in which 10 patients consumed 5 g test rice daily. Read More

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http://dx.doi.org/10.12932/AP-050619-0575DOI Listing
October 2019

The quantity of unheated milk tolerated as a predictor of tolerance to baked milk.

Asian Pac J Allergy Immunol 2019 Oct 6. Epub 2019 Oct 6.

Department of Pediatric Allergy, Dr Behcet Uz Children's Hospital, Izmir, Turkey.

Background: Tolerance of baked milk indicates a good prognosis in IgE-mediated cow's milk allergy.

Objective: The present study aims to investigate the predictors of baked milk tolerance, particularly the amount of milk tolerated in the first oral food challenge (OFC) test, in children with IgE-mediated cow's milk allergy.

Methods: The study included 35 cases who were diagnosed with IgE-mediated cow's milk allergy upon open OFC testing in the Pediatric Allergy Clinic. Read More

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http://dx.doi.org/10.12932/AP-280419-0549DOI Listing
October 2019
1 Read

Effect of Hatha yoga training on rhinitis symptoms and cytokines in allergic rhinitis patients.

Asian Pac J Allergy Immunol 2019 Aug 18. Epub 2019 Aug 18.

Faculty of Sports Science, Exercise Physiology in Special Population Research Group, Chulalongkorn University, Bangkok, Thailand.

Introduction: Allergic rhinitis is an inflammation of the nasal mucosa in response to allergens. There is evidence that yoga can improve personal health and has positive effects on immune function. However, the effects of Hatha yoga training on rhinitis symptoms and cytokines in patients with allergic rhinitis are still unclear. Read More

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http://dx.doi.org/10.12932/AP-260419-0547DOI Listing
August 2019
6 Reads

Antiallergic activities of shallot (Allium ascalonicum L.) and its therapeutic effects in allergic rhinitis.

Asian Pac J Allergy Immunol 2019 Aug 18. Epub 2019 Aug 18.

Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Japan.

Background: Onion has antiallergic activity but lack of evidence for shallot.

Objectives: To determine whether shallot owns similar antiallergic activity to onion and its therapeutic effects in allergic rhinitis when added to standard treatment METHODS: In-vitro β-hexosaminidase inhibitory activities of shallot was compared with onion on RBL-2H3 cells. In clinical study, a randomized, double-blind, placebo-controlled trial was performed. Read More

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http://dx.doi.org/10.12932/AP-300319-0529DOI Listing
August 2019
1 Read
1.255 Impact Factor