1,499 results match your criteria Asian Pacific Journal of Tropical Medicine[Journal]


Gender disparity in COVID-19: Role of sex steroid hormones.

Asian Pac J Trop Med 2021 5;14(1):5-9. Epub 2021 Jan 5.

St Johns Research Institute and St Johns Medical College, St Johns National Academy of Health Sciences, Bangalore-560034. Karnataka, India.

The emerging pandemic of COVID-19 caused by the novel pathogenic human coronavirus SARS-CoV-2 has caused significant morbidity and mortality across the globe, prompting the scientific world to search for preventive measures to interrupt the disease process. Demographic data indicates gender-based differences in COVID-19 morbidity with better outcome amongst females. Disparity in sex-dependent morbidity and mortality in COVID-19 patients may be attributed to difference in levels of sex steroid hormones -androgens and estrogens. Read More

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January 2021

Polyphenolic content, in vitro antioxidant activity and chemical composition of extract from Nephelium lappaceum L. (Mexican rambutan) husk.

Asian Pac J Trop Med 2017 Dec 7;10(12):1201-1205. Epub 2017 Nov 7.

Department of Animal Nutrition, Universidad Autónoma Agraria Antonio Narro, Col. Buenavista, Calzada Antonio Narro No. 1923, Saltillo, 25315, Coahuila, Mexico. Electronic address:

Objective: To determinate the recovery of total polyphenolic compounds content, in vitro antioxidant activity and HPLC/ESI/MS characterization of extract from Nephelium lappaceum L. (Mexican rambutan).

Methods: The rambutan husk extract was obtained by aqueous extraction and a polyphenolic fraction was recovered using Amberlite XAD-16. Read More

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December 2017

Electrophysiological changes of autonomic cells in left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with chronic heart failure.

Asian Pac J Trop Med 2017 Dec 6;10(12):1197-1200. Epub 2017 Nov 6.

Department of Obstetrics and Gynecology, The Sixth Hospital of Zhangjiakou, 075000 Zhangjiakou, Hebei, China.

Objective: To investigate the electrophysiological changes of autonomic cells in left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with chronic heart failure.

Methods: Guinea pigs model of iron deficiency anemia complicated with chronic heart failure in 10 guinea pigs of the experimental group was made by feeding a low iron diet, pure water and subcutaneous injection of isoproterenol. The control group consisting of 11 guinea pigs was given normal food, normal water and injected with normal saline. Read More

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December 2017

Reverse effect of curcumin on CDDP-induced drug-resistance via Keap1/p62-Nrf2 signaling in A549/CDDP cell.

Asian Pac J Trop Med 2017 Dec 31;10(12):1190-1196. Epub 2017 Oct 31.

Pharmacy School, Wannan Medical College, Wuhu, Anhui 241002, China; Anhui Provincial Engineering Research Center for Polysaccharides Drugs, Wannan Medical College, Wuhu, Anhui 241001, China. Electronic address:

Objective: To assess the effect of curcumin on CDDP-induced drug resistance and explore the underlying molecular mechanism through Nrf2 system and autophagy pathway.

Methods: A drug-resistant cell model was established by exposing A549/CDDP cell to 2 μg/mL CDDP. A549/CDDP cell was treated with 20 μg/mL CDDP and 10 μM curcumin. Read More

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December 2017

Expression of vimentin and glial fibrillary acidic protein in central nervous system development of rats.

Asian Pac J Trop Med 2017 Dec 28;10(12):1185-1189. Epub 2017 Oct 28.

Department of Anatomy & Histology & Embryology, Kunming Medical University, Kunming, Yunnan, 650500, China. Electronic address:

Objective: To investigate the distribution and contents of vimentin (Vim) and glial fibrillary acidic protein (GFAP) immunoreactivities in the central nervous system (CNS) of normal newborn, adult and aged rats.

Methods: In this study, thirty healthy and normal Sprague-Dawley rats were simply classified into three groups: Newborn (7 days aged), adult (5 months aged) and aged (24 months aged) rats. Brains and spinal cord were dissected and cut into frozen sections. Read More

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December 2017

Development of a mouse model of arecoline-induced oral mucosal fibrosis.

Asian Pac J Trop Med 2017 Dec 29;10(12):1177-1184. Epub 2017 Oct 29.

Department of Oral Medicine, Haikou City People's Hospital, Haikou 570100, China.

Objective: To develop a BALB/c mouse model of oral submucous fibrosis (OSF) induced by arecoline and to exhibit an accumulation of collagen and angiogenesis changes.

Methods: BALB/c mice were randomly assigned to either the control (distilled water) or experimental group (arecoline) (n = 40). Eight mice from each group were sacrificed every 4 weeks since 8 weeks post treatment. Read More

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December 2017

Regulating effect of glycyrrhetinic acid on bronchial asthma smooth muscle proliferation and apoptosis as well as inflammatory factor expression through ERK1/2 signaling pathway.

Asian Pac J Trop Med 2017 Dec 28;10(12):1172-1176. Epub 2017 Oct 28.

Department of Pediatrics, the First Affiliated Hospital, Jinan University, Guangzhou, China.

Objective: To study the influence of glycyrrhetinic acid (GA) on bronchial asthma (BA) smooth muscle proliferation and apoptosis as well as inflammatory factor expression and its molecular mechanism.

Methods: Male SD guinea pigs were selected and made into asthma models, bronchial asthma smooth muscle cells were cultured and divided into BA group, GA group and GA + LM group that were treated with serum-free RPMI1640 culture medium, serum-free RPMI1640 culture medium containing 50 ng/mL glycyrrhetinic acid, serum-free RPMI1640 culture medium containing 50 ng/mL glycyrrhetinic acid and 100 ng/mL LM22B-10 respectively; normal guinea pigs were collected and bronchial smooth muscle cells were cultured as control group. The cell proliferation activity as well as the expression of proliferation and apoptosis genes, inflammatory factors and p-ERK1/2 was determined. Read More

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December 2017

Faunal data and envenomation emergency first aid of cone snails (Conus spp.) in Qeshm Island, the Persian Gulf.

Asian Pac J Trop Med 2017 Dec 31;10(12):1167-1171. Epub 2017 Oct 31.

Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: To investigate the fauna of a highly venomous marine species group, the cone snails (Family Conidae), in the shores of Qeshm Island, of evaluating the possibility of envenomation in the area and summarize recommendations for emergency first aid.

Methods: Shores surrounding Qeshm Island were surveyed to collect cone snails during cold (February and March) and warm (May and June) seasons of 2017. Collected snails were identified to the species level. Read More

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December 2017

Some pathogenic characters of paratyphoid Salmonella enterica strains isolated from poultry.

Asian Pac J Trop Med 2017 Dec 31;10(12):1161-1166. Epub 2017 Oct 31.

Department of Veterinary Science, University of Pisa, Viale Delle Piagge 2, 56124 Pisa Italy.

Objective: To investigate some pathogenic characters of Salmonella enterica strains isolated from poultry.

Methods: Twenty-three genetically distinct Salmonella enterica strains, of different serovars and pulsotype, were examined for virulence traits. Resistance to gastric acid environment was estimated by measuring the percentage of survived bacterial cells after exposure for 2 h to a synthetic gastric juice. Read More

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December 2017

Antibiofilm activity of α-mangostin extracted from Garcinia mangostana L. against Staphylococcus aureus.

Asian Pac J Trop Med 2017 Dec 31;10(12):1154-1160. Epub 2017 Oct 31.

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down Bath, BA2 7AY, Bath, UK. Electronic address:

Objective: To isolate α-mangostin (AMG) from the peels of mangosteen (Garcinia mangostana L.), grown in Vietnam, and to investigate antibiofilm activity of this compound against three Staphylococcus aureus (S. aureus) strains, one of which was methicillin-resistant S. Read More

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December 2017

Pharmacological evaluation of smooth muscle relaxant and cardiac-modulation potential of Phyla nodiflora in ex-vivo and in-vivo experiments.

Asian Pac J Trop Med 2017 Dec 31;10(12):1146-1153. Epub 2017 Oct 31.

Faculty of Pharmacy, Bahauddin Zakariya University, 60800, Multan, Pakistan. Electronic address:

Objective: To investigate the pharmacological basis of its uses of Phyla nodiflora (P. nodiflora) for the treatment of anomalies predominantly by smooth muscle containing tissues such as gastrointestinal/vascular/broncho spasm and cardiovascular modulation.

Methods: The crude hydroalcoholic extract of P. Read More

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December 2017

Bacteriocin-like inhibitory substance (BLIS) activity of Streptococcus macedonicus MBF10-2 and its synergistic action in combination with antibiotics.

Asian Pac J Trop Med 2017 Dec 24;10(12):1140-1145. Epub 2017 Nov 24.

Pharmaceutical Microbiology and Biotechnology Research Group, Faculty of Pharmacy, Universitas Indonesia, UI Campus Depok, Depok 16424, Indonesia. Electronic address:

Objective: To characterize the bacteriocin-like inhibitory-substances (BLIS) activity of Streptococcus macedonicus MBF10-2 [named BLIS(MBF10-2)], a bacteriocinogenic strain isolated from an Indonesian tofu byproduct.

Methods: BLIS(MBF10-2) was obtained by culturing the bacterium, and standard deferred antagonism assays were used to demonstrate its activity. The antibacterial testing of fractions collected by filtration using 3-30 kDa cut-off membrane sizes were carried out by performing well diffusion method. Read More

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December 2017

Phytochemical analysis and biological activities of Hertia cheirifolia L. roots extracts.

Asian Pac J Trop Med 2017 Dec 28;10(12):1134-1139. Epub 2017 Oct 28.

Laboratory of Transmissible Diseases and of Biologically Active Substances, MDT01, Faculty of Pharmacy, University of Monastir, Tunisia.

Objective: To test the antioxidant, antimicrobial and α-glucosidase inhibitory activities of the roots extracts from Hertia cheirifolia (H. cheirifolia) L.

Methods: Total phenolics and total flavonoids content of the different extracts were determined by colorimetric methods and reverse phase high-performance liquid chromatography (RP-HPLC) was performed to identify various chemical components. Read More

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December 2017

Rescue effects of aqueous seed extracts of Foeniculum vulgare and Carum carvi against cadmium-induced hepatic, renal and gonadal damage in female albino rats.

Asian Pac J Trop Med 2017 Dec 29;10(12):1123-1133. Epub 2017 Oct 29.

Department of Theriogenology, Faculty of Veterinary Medicine, Beni-Suef University, 62512 Beni-Suef, Egypt.

Objective: To investigate the protective effects of aqueous seed extracts of fennel "Foeniculum vulgare" (FVE) and caraway "Carum carvi" (CCE) on liver, kidney and reproductive organs in female rats against cadmium chloride (CC) intoxication.

Methods: A total of 36 adult female rats were divided into six groups, six in each group. Control group (fed normal diet), CC-treated group (50 mg CC/kg diet), CCE-treated group (150 mg CCE/kg diet), CCE + CC group, FVE (150 mg/kg diet) and FVE + CC. Read More

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December 2017

Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease.

Asian Pac J Trop Med 2017 Dec 28;10(12):1117-1122. Epub 2017 Oct 28.

Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea. Electronic address:

Objective: To discover lead lupane triterpenoid's potential isolated from Pueraria lobata roots against β-site amyloid precursor protein cleaving enzyme 1 (BACE1), which serve as a rate limiting step in amyloid beta (Aβ) production altering the course of Alzheimer's disease. In addition, enzyme kinetics study and molecular docking were conducted to establish the inhibition type and structure activity relationship.

Methods: A systematic study of 70% ethanolic P. Read More

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December 2017

Antioxidants: Friend or foe?

Asian Pac J Trop Med 2017 Dec 28;10(12):1111-1116. Epub 2017 Oct 28.

Private Dental Practitioner, Sai Raghav Dental Clinic, Chennai, India.

Reactive oxygen species are the intermediates that are formed during the normal metabolic process which are effectively neutralized by the antioxidant system of the body. Any imbalance in this neutralization process causes oxidative stress which has been implicated as one of the cause in diseases such as Alzheimer's disease, cardiovascular disorders, cancer etc. Research has enabled the use of antioxidants as therapeutic agents in the treatment of various diseases. Read More

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December 2017

Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update.

Asian Pac J Trop Med 2017 Dec 7;10(12):1105-1110. Epub 2017 Nov 7.

Unidad de Investigación Médica en Farmacología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Delg. Cuauhtémoc, 06720 Ciudad de México, Mexico. Electronic address:

Leishmaniasis is considered as an emerging, uncontrolled disease and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500000 cases of visceral-type leishmaniasis are recorded and 60000 persons died from the disease. In Mexico, cutaneous leishmaniasis is known as chiclero's ulcer and is reported in 22 states, it is considered as a health problem. Read More

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December 2017

An atypical case of disseminated cutaneous leishmaniasis due to Leishmania peruviana in the valleys of Ancash-Peru.

Asian Pac J Trop Med 2017 Nov 7;10(11):1101-1103. Epub 2017 Nov 7.

School of Medicine, Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cdra 2 Cedros de Villa, Lima, Peru; Research Center and Innovation of the Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cdra 2 Chorrillos, Lima, Peru. Electronic address:

We present an atypical case of disseminated cutaneous leishmaniasis in the Sihuas district, located in the Andean valleys of Ancash-Peru. A 62-year-old man with no particular medical history presented multiple lesions located on the inferior abdomen, lumbar region and the right anterior thigh. Histological analysis found leishmanial amastigotes in the lesion sample, the Montenegro reaction was positive for Leishmania spp, and the polymerase chain reaction was positive for Leishmania peruviana. Read More

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November 2017

Influence of light intensity and water content of medium on total dendrobine of Dendrobium nobile Lindl.

Asian Pac J Trop Med 2017 Nov 28;10(11):1095-1100. Epub 2017 Oct 28.

Guizhou University, Guiyang, Guizhou 550025, China; Guizhou Key (Engineering) Laboratory for Propagation and Cultivation of Medicinal Plants, Guiyang 550025, China.

Objective: To ascertain the influence of light intensity and water content of medium on the total dendrobine of Dendrobium nobile (D. nobile).

Method: The principal component analysis combined with total dendrobine accumulation was conducted to assess the yield and quality of D. Read More

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November 2017

Effect of taurine on immune function in mice with T-cell lymphoma during chemotherapy.

Asian Pac J Trop Med 2017 Nov 28;10(11):1090-1094. Epub 2017 Oct 28.

Department of Hematology and Rheumatology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350000, China.

Objective: To observe the effect of taurine on immune function in mice with T-cell lymphoma during chemotherapy.

Methods: A total of 40 C57BL/6 mice were selected and randomly divided into 4 groups, namely model group, chemotherapy group, taurine group and chemotherapy + taurine group, each containing 10 mice. Hypodermic injection was adopted to inoculate EL-4 cells in order to establish model of T-cell lymphoma. Read More

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November 2017

Glypican-3-specific cytotoxic T lymphocytes induced by human leucocyte antigen-A*0201-restricted peptide effectively kill hepatocellular carcinoma cells in vitro.

Asian Pac J Trop Med 2017 Nov 28;10(11):1084-1089. Epub 2017 Oct 28.

Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510310, China. Electronic address:

Objective: To investigate potential human leucocyte antigen (HLA)-A2-restricted epitope peptides of glypican-3 (GPC3) and determine the cytotoxicity of peptide-specific cytotoxic T lymphocytes (CTLs) against hepatocellular carcinoma (HCC) cells.

Methods: The potential HLA-A*0201-restricted GPC3 peptides were screened using computer algorithms, T2 cell-binding affinity and stability of peptide/HLA-A*0201 complex assay. The peptide-specific CTLs were generated and their cytotoxicity against GPC3 SMMC 7721 and HepG2 cells was detected using IFN-γ based enzyme-linked immunospot and lactate dehydrogenase release assays in vitro. Read More

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November 2017

Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions.

Asian Pac J Trop Med 2017 Nov 28;10(11):1080-1083. Epub 2017 Oct 28.

Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Paraná, Brazil.

Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus (PDA) in premature neonates with significant clinical and hemodynamic repercussions (CHRs) and to determine the effect of these respective treatments on renal function.

Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin [0. Read More

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November 2017

Bartonella infection in asymptomatic horses and donkeys from Tuscany, Central Italy.

Asian Pac J Trop Med 2017 Nov 28;10(11):1077-1079. Epub 2017 Oct 28.

Department of Veterinary Science, University of Pisa, Viale Delle Piagge 2, 56124 Pisa, Italy. Electronic address:

Objective: To investigate the occurrence of Bartonella sp. infection in asymptomatic horses and donkeys living in Tuscany, Central Italy.

Methods: Blood samples were collected from 77 horses and 15 donkeys and tested by indirect immunofluorescent test to detect antibodies against Bartonella sp. Read More

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November 2017

Evaluating the effect of Myrtus communis on programmed cell death in hydatid cyst protoscolices.

Asian Pac J Trop Med 2017 Nov 28;10(11):1072-1076. Epub 2017 Oct 28.

Department of Social Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Objective: To evaluate the possible involvement of programmed cell death strategy in hydatid cyst protoscolices following treatment with Myrtus communis (M. communis) as an herbal medicine.

Methods: Protoscolices were aseptically collected from sheep liver hydatid cysts. Read More

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November 2017

Association of TNFA (-308G/A), IFNG (+874 A/T) and IL-10 (-819 C/T) polymorphisms with protection and susceptibility to dengue in Brazilian population.

Asian Pac J Trop Med 2017 Nov 28;10(11):1065-1071. Epub 2017 Oct 28.

Molecular Biology and Gene Expression Laboratory, Federal University of Alagoas, Campus Arapiraca, Av Manoel Severino Barbosa, Bom Sucesso, Arapiraca, AL, 57309-005, Brazil. Electronic address:

Objective: To evaluate gene polymorphisms and their association with susceptibility to dengue.

Methods: A retrospective case-control study was performed with 262 subjects, comprising 78 dengue fever (DF) patients, 49 dengue hemorrhagic fever (DHF) patients and 135 healthy controls. Genotypic and allelic profiles were identified using polymerase chain reaction based in real time and amplification-refractory mutation system. Read More

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November 2017

Antimicrobial resistance and underlying mechanisms in Staphylococcus aureus isolates.

Asian Pac J Trop Med 2017 Nov 8;10(11):1059-1064. Epub 2017 Nov 8.

Department of Microbiology, Faculty of Veterinary Medicine, Mustafa Kemal University, Antakya-Hatay, 31040, Turkey.

Objective: To investigate the antimicrobial susceptibility of 97 clinical Staphylococcus aureus (S. aureus) strains against 14 antimicrobials and corresponding resistance mechanisms.

Methods: The antimicrobial susceptibility of the isolates was determined using a disk diffusion method and antimicrobial resistance genes were screened by polymerase chain reaction. Read More

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November 2017

Efficient hepatoprotective activity of cranberry extract against CCl-induced hepatotoxicity in Wistar albino rat model: Down-regulation of liver enzymes and strong antioxidant activity.

Asian Pac J Trop Med 2017 Nov 27;10(11):1054-1058. Epub 2017 Oct 27.

Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300, Selangor, Malaysia. Electronic address:

Objective: To investigate the hepatoprotective efficacy of cranberry extract (CBE) against carbon tetrachloride (CCl)-induced hepatic injury using in-vivo animal model.

Methods: The hepatoprotective efficacy of CBE (200 and 400 mg/kg) was investigated against CCl (4 mL/kg)-induced hepatotoxicity, elevated liver enzymes [ALT (alanine aminotransferase), AST (aspartate aminotransferase), and alkaline phosphatase (ALP)], and total protein (TP) contents in the serum. Moreover, CBE-aided antioxidant defense against hepatotoxic insult of CCl was measured by evaluating a number of anti-oxidative biomarkers including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in the serum by using spectrophotometric analyses. Read More

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November 2017

Antioxidant, anti-inflammatory and antinociceptive potential of Ternstroemia sylvatica Schltdl. & Cham.

Asian Pac J Trop Med 2017 Nov 27;10(11):1047-1053. Epub 2017 Oct 27.

Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Xalapa, Veracruz, Mexico. Electronic address:

Objective: To evaluate the anti-inflammatory, analgesic, antioxidant and acute toxicity of extracts obtained from a successive extraction with solvents of ascending polarity [hexane, hex; chloroform, CHCl and ethanol (EtOH)] of Ternstroemia sylvatica Schltdl. & Cham.

Methods: The antioxidant potential was evaluated by 2,2 diphenyl-1-picrylhydrazyl, the ferric reducing/antioxidant power assays and by determining the total phenolic content. Read More

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November 2017

Effects of 8-Hydroxyisocapnolactone-2-3-diol and friedelin on mast cell degranulation.

Asian Pac J Trop Med 2017 Nov 31;10(11):1043-1046. Epub 2017 Oct 31.

Department of Pharmacology, Graduate School of Medicine, Ehime University, Ehime, 791-0295, Japan.

Objective: To investigate the effects of friedelin (terpenoid) and 8-hydroxyisocapnolactone-2-3-diol (coumarin) with concentration 10 μM, 30 μM, and 100 μM on inhibiting mast cells (MCs) degranulation.

Methods: The investigation was performed in vitro by administering each compound into rat peritoneal MCs and rat basophilic leukemia-2H3 cells followed by activation with 50 μg/mL of compound 48/80 or 1 μM of ionomycin. The concentration of histamine released from each group was measured by a high-performance liquid chromatography-fluorometry system with post-column derivatization using o-phthalaldehyde. Read More

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November 2017

Pattern of hepatitis C virus genotypes and subtypes circulating in war-stricken Khyber Pakhtunkhwa, Pakistan: Review of published literature.

Asian Pac J Trop Med 2017 Nov 7;10(11):1037-1042. Epub 2017 Nov 7.

Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan.

Infection due to hepatitis C virus (HCV) is a major cause of fibrosis and hepatocellular carcinoma in Pakistan. In the current review, pattern of HCV genotypes and subtypes in Khyber Pakhtunkhwa province was ascertained in light of the available literature. After thorough analysis, genotype 3 (58. Read More

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November 2017