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Asian Pac J Cancer Prev 2022 Apr 1;23(4):1433-1444. Epub 2022 Apr 1.

Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Objective: Programmed death-ligand 1 (PD-L1) and human epidermal growth factor receptor 2 (HER2) are currently considered as prognostic markers and therapeutic targets in many human cancers. This study aims to evaluate immunohistochemical (IHC) expression of PD-L1 in gastric cancer (GC) and explore its prognostic role in terms of association with HER2 expression, different clinico-pathological variables, in particular density and cluster designation (CD)8 positivity in tumor infiltrating lymphocytes (TILs) and with patients' disease-free and overall survival (DFS, OS).

Methods: This retrospective cohort study included 111 diagnosed primary GC patients who underwent surgical resection at the Gastrointestinal Surgery Center (GISC), Faculty of Medicine, Mansoura University, Egypt. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1425-1432. Epub 2022 Apr 1.

Department of Pathology, Kasr-Al-Ainy, Cairo University, Cairo, Egypt.

Objective: Evaluation of SOX-10 expression in malignant urothelial cells, comparing it with the phenotypically non neoplastic urothelium, and correlating it with the various clinicopathological variables, with a focus on the invasive pattern.

Methods: Eighty paraffin blocks of urothelial carcinoma were stained by H&E. Histopathological features were evaluated and then immunostained with SOX-10 to evaluate its expression. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1415-1423. Epub 2022 Apr 1.

PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Tungku Link Road, Brunei Darussalam.

Background: This study provides population-based study of cancer incidence, mortality and survival rates for women diagnosed with epithelial ovarian cancer (EOC), and evaluate the prognostic factors of EOC patients survival in Brunei Darussalam.

Methods: This is a retrospective  study of patients diagnosed with EOC between 1st January 2007 and 31st December 2017 in Brunei Darussalam. Crude, age-specific, age-standardized incidence and mortality rates per 100,000 women were calculated. Read More

Asian Pac J Cancer Prev 2022 04 1;23(4):1405-1413. Epub 2022 Apr 1.

Department Pharmacology and Toxicology, College of Pharmacy, AL-Nahrain University, Iraq.

Objective: Angiogenesis is new blood vessels formations that are necessary for certain physiological and pathologic conditions. Almond oil represents adjuvant therapies for numerous health benefits; It has ability for prevent the formation angiogenesis in tumour, due to its high concentration of unsaturated fatty acids, polyphenols, flavonoids and other ingredients content. Aspirin is non-steroidal ant-inflammatory drug; significantly reduce the angiogenesis of cancer. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1397-1403. Epub 2022 Apr 1.

Department of Radiation Oncology, Fortis Cancer Institute, Fortis Hospital, Mohali, Punjab, India.

Objective: To study the dosimetric importance of Jaw tracking technique in reducing the doses to organs at risk (OAR) while achieving the optimal dose coverage for the target.

Methods: We retrospectively selected ten Glioblastoma cases and for each patient, two plans were created namely Static Jaw Technique Dynamic Intensity Modulated Radiotherapy plan and Jaw Tracking Technique D-IMRT plan with 6 MV for Varian Truebeam™ STx machine using Eclipse Treatment planning system. Both plans were analyzed and compared based on various dosimetric parameters for Planning Target Volume (PTV) and OARs. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1387-1395. Epub 2022 Apr 1.

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Ministry of High Education, Lattakia, Syria.

Objective: Among all types of hematological neoplasms, acute myeloid leukemia (AML) has the highest death rate. Recently, cytogenetic and molecular genetics are crucial in the management, as a consequence of their effect on AML pathogenesis, classification, risk-stratification, prognosis and treatment.

Methods: 100 Syrian adults with Normal Karyotype (NK) newly diagnosed  AML patients were included in this study, all cases confirmed histologically and immunohistochemically. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1379-1385. Epub 2022 Apr 1.

Department of Surgical, National Institute of Oncology, Rabat, Morocco.

The increasing incidence of colorectal cancer in Morocco has generated a need for a disease-specific quality-of-life measuring instrument. The present study aims to translate and evaluate the reliability and validity of the Moroccan Arabic version of the EORTC QLQ-C29 measure in Moroccan subjects with colorectal cancer (CRC).

Methods: Following translation to Moroccan Arabic, The QLQ-C30 and QLQ-C29 were administered to 135 patients treated for colorectal cancer (CRC) at the national oncology institute of Rabat, in the period from February 2016 to June 2018. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1373-1377. Epub 2022 Apr 1.

Internal Medicine Department, Beni-Suef University, Egypt.

Background: Hepatocellular carcinoma (HCC) is a common cancer with substantial cancer-related deaths worldwide. Deregulation of some genetic polymorphisms has been identified in HCC.

Objective: We aimed to demonstrate the frequency of miRNA 196a2 rs11614913 and miRNA 34 b/c rs4938723 gene polymorphisms in HCC patients and their correlation with the clinical features and laboratory findings at diagnosis. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1365-1372. Epub 2022 Apr 1.

Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Objective: The co-infection of HCV/CMV may accelerate the progression of liver diseases and worsen responsiveness to IFN treatment. The Direct-acting antiviral agents (DAAs), currently approved therapy for HCV, may cause a transient change in immune status, favoring the reactivation of other viruses. The current study aims to evaluate the impact of DAAs treatment on the reactivation of latent CMV in HCV patients. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1359-1364. Epub 2022 Apr 1.

Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: Breast cancer (BC) is one of the major health problems affecting females in Egypt. Certain chromosomal loci abnormalities were proved to be associated with BC in different populations. One of them is chromosomal locus 6q25. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1351-1358. Epub 2022 Apr 1.

College of Medicine and Public Health, Ubon Ratchathani University, 85 Sathonmak Road, Warinchamrap, Ubon Ratchathani, Thailand.

Objective: To examine the effects of ibuprofen, naproxen and diclofenac, non-steroidal anti-inflammatory drugs (NSAIDs) on cell proliferation activity of the human CCA cell lines.

Methods: KKU-M139 and KKU-213B cell lines were used in this study. The cell viability was assessed by the MTT assay. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1345-1350. Epub 2022 Apr 1.

Department of Chemistry of Tannins, National Research Centre, Cairo, Egypt.

Objective: Bombax ceiba (red Silk cotton tree) has great ethnopharmacological significance due to its widespread use to treat various diseases such as dysentery, inflammation, and tuberculosis. Despite decades of research, the studies on the in vitro anticancer/genotoxic activity of B. ceiba flower remains restricted. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1337-1343. Epub 2022 Apr 1.

Dharma Husada Nursing Academy, Kediri 64114, East Java, Indonesia.

Objective: Lung cancer is the leading cause of death among cancer patients. The majority of lung cancer is the Non-Small Lung Carcinoma (NSLC). This study evaluated the potency of brazilin isolated from Caesalpinia sappan wood to induce apoptosis on non-small lung carcinoma cell line, A549, by examining the expression of p53, caspase-9, and caspase-3. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1331-1336. Epub 2022 Apr 1.

Division of Medical Oncology, Department of Internal Medicine, Buddhasothorn Hospital, Chachoengsao, Thailand.

Objective: To study the efficacy of the prevention of immediate hypersensitivity reactions (HSRs) from omitting ranitidine in the premedication protocol in patients who had chemotherapy with taxane regimen.

Methods: This was a Multicenter, Ambispective Non-Randomized Historical Controlled Cohort Study. The incidence of HSRs in the patients who had the modified premedication without ranitidine were collected to compare with the historical group who had the standard premedication protocol with ranitidine. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1325-1330. Epub 2022 Apr 1.

Faculty of Economics and Business, Universitas Indonesia, Depok, West Java, Indonesia.

Objective: This study aims to investigate the impact of cigarette consumption on household's nutrition adequacy (NA). This study also examines the opportunity cost of cigarette expenditure to children's nutritional adequacy.

Methods: We used an Indonesian cross-sectional household level nationwide data of 2018 National Socio-Economic Survey (SUSENAS). Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1315-1324. Epub 2022 Apr 1.

Faculty of Engineering, Gifu University, Gifu, Japan.

Objective: It is essential to accurately diagnose and classify histological subtypes into adenocarcinoma (ADC), squamous cell carcinoma (SCC), and small cell lung carcinoma (SCLC) for the appropriate treatment of lung cancer patients. However, improving the accuracy and stability of diagnosis is challenging, especially for non-small cell carcinomas. The purpose of this study was to compare multiple deep convolutional neural network (DCNN) technique with subsequent additional classifiers in terms of accuracy and characteristics in each histology. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1309-1314. Epub 2022 Apr 1.

Department of Public Health Administration, Health Promotion, and Nutrition, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.

Objective: Cannabis is therapeutic for numerous medical conditions. The demand for medical cannabis (MC) use in cancer patients is increasing, even with many patients lacking proper knowledge about MC. Therefore, this study aimed to describe the attitudes and beliefs of cancer patients demanding MC use in northern Thailand. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1301-1308. Epub 2022 Apr 1.

Department of Oncology Center, King Abdulaziz Medical City, AlAhsa, kingdom of Saudi Arabia.

Introduction: Colorectal cancer (CRC) ranked first among cancers reported in males and ranked third amongst females in Saudi Arabia. CRC cancer symptoms or symptoms secondary to treatment, such as diarrhea, constipation, fatigue and loss of appetite are very common and has significant negative effects on the quality of life (QoL).

Methods: This project was a cross-sectional study of colorectal cancer survivors diagnosed between 1 January 2015 and May 2017. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1291-1300. Epub 2022 Apr 1.

Department of Molecular Biology, Genetics Krishna Institute of Medical Sciences, Deemed to Be University Malkapur, Karad Satara, Maharashtra, Pin: 415 539, India.

Background: Last few years, several studies all over the world revealed the association of DNA repair genes with risk of developing different type of cancers, but were ambiguous to support the evidences in case of cervical cancer risk. These differences in earlier studies directed us to study the association of polymorphisms of BER genes (XRCC1, hOGG1, XPC) and NER genes (XPC, XPD) with cervical cancer susceptibility in the women of rural population of Maharashtra.

Materials And Methods: The genetic polymorphism in BER and NER pathway genes was studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method using DNA isolated from intravenous blood samples of patients and normal controls. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1285-1290. Epub 2022 Apr 1.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.

Aim: Human Papillomavirus is one of the most crucial infectious disease in gynecology disease. To assess the efficacy of supplemental zinc treatment in clearance of HPV infection.

Methods: Eighty zinc-sufficient women between 21-55 years, with positive HPV DNA testing, and abnormal cervical cytology in Pap test (ASCUS or LISL) were randomly divided to case (n=40) and control group (n=40). Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1279-1284. Epub 2022 Apr 1.

Nakorn Nayok Hospital, Nakorn Nayok, Thailand.

Objective: Chronic liver disease has become a leading cause of illness and death in people living with HIV and the production of the cytokines IFN-γ and TGF-β1, and chemokine CXCL10 during chronic inflammation contributes to liver disease progression in HIV patients under long-term anti-retroviral therapy. This study aimed to examine association of IFN-γ +874T/A, CXCL10 G-201A and C-1596T, and TGF-β1 -509C/T single nucleotide polymorphisms (SNPs) with liver complications in the HIV-infected Thais.

Methods: A cross-sectional study was conducted in 200 Thai HIV patients who were evaluated for transaminitis and significant liver fibrosis by fibrosis-4 score (FIB-4), and genotypes for IFN-γ +874T/A, CXCL10 G-201A and C-1596T, and TGF-β1 -509C/T SNPs using PCR-based methods. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1271-1278. Epub 2022 Apr 1.

Department of Molecular and Tumour Pathology, Akita University Graduate School of Medicine, Akita, 010-8543 Japan.

Background: Tumor-infiltrating lymphocytes (TILs) are assessed by the ratio of the area of lymphocytes infiltrating the stroma. TILs are important in breast cancer and malignant melanoma and are being established as a marker of prognosis and sensitivity to chemotherapy. This has resulted in various therapies being developed in fields such as breast cancer. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1263-1270. Epub 2022 Apr 1.

Clinical Research Department Center, Imam Reza Hospital, Kermanshah University of Medical Science, Kermanshah, Iran.

According to the instructions of Iran's National Corona Response Committee in the Iranian Ministry of Health and Medical Education, patients undergoing treatments for their cancer are prioritized in Covid-19 vaccination. The present study was therefore conducted to investigate the toxicity and acute side-effects of a Covid-19 vaccine in cancer patients presenting to Medical Oncology Clinic of Kermanshah University of Medical Science. After excluding the patients with active infection and the recently-infected ones with Covid-19, they underwent the vaccination. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1257-1262. Epub 2022 Apr 1.

Faculty of Economics and Business, University of Indonesia, Depok, Indonesia.

Background: E-cigarette use is a growing public health concern globally, including in Indonesia.

Objective: Our study aimed to assess whether exposure to advertising and promotion in social media is associated with e-cigarette use in Indonesia, an upper-middle-income country.

Methods: We conducted mixed-method research including quantitative and qualitative methods. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1247-1256. Epub 2022 Apr 1.

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus 00970, Palestine.

Background: Understanding the university students' perception of Water Pipe smoking addictions and factors behind the rise in the prevalence of Water Pipe smoking will contribute effectively in the prevention strategies and policies development.

Aims: Thus, this study aims to assess the prevalence of Water Pipe smoking among university students and their perceptions on its addiction in Palestine, Jordan, and Turkey, as an initial step to reduce the spread of Water Pipe smoking.

Methods: An online self-structured questionnaire was administered to 2030 selected university students from Palestine, Jordan, and Turkey. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1239-1246. Epub 2022 Apr 1.

Faculty of Medicine, Menoufia University, Shebin El-kom, Menoufia, Egypt.

Introduction: Periampullary adenocarcinoma (PAAC) is a rare, lethal heterogeneous group of malignancy that differs in their molecular phenotypes. Ecto-5'-nucleotidase (CD73)/adenosine A2A Receptor (A2AR) pathway has shown an emerging role in cancer therapy through modulating the immune response. Therefore, this study aimed to explore the functional role of CD73 and A2AR in pancreatic ductal adenocarcinoma (PDAC) and ampullary carcinoma (AC). Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1231-1238. Epub 2022 Apr 1.

Department of Public Health, Faculty of Health Sciences, Universitas Jenderal Soedirman, Purwokerto, Indonesia.

Background: Cancer remains a significant public health problem in Indonesia and worldwide. Yogyakarta Province has the largest number of cancer cases in Indonesia. Maps of the distribution of cancer cases are useful tools for stratification of cancer risk and for selective prevention strategies. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1223-1229. Epub 2022 Apr 1.

Department of Public Health, Faculty of Medicine, Dokuz Eylul University, Balçova, İzmir, Turkey.

Background/aim: Epidemiological studies indicate that the risk of several types of cancer is high in diabetic patients. The aim of this study is to evaluate the association between diabetes and diabetes related cancers in a cohort design.

Materials And Methods: The baseline survey was conducted as a community screening programme from 2007 to 2009 in a population over 30 years of age. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1215-1222. Epub 2022 Apr 1.

Department of Pathology, National Research Centre (NRC), Dokki, Giza, Egypt.

Objective: Lavender oil is of a great economic importance. It has many biological and pharmacological activities. The present study aimed to identify the chemical constituents of the essential oil of Lavandula officinalis (LAEO) by using GC/MS analysis. Read More

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1207-1213. Epub 2022 Apr 1.

Social Determinants of Health Research Center, Department of Health and Management, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: This study sought to investigate Iranian women's preferences and willingness-to-pay (WTP) based on the level of breast self-examination and mammography screening practice and knowledge, including risk factors, signs and symptoms, and early detection methods via mammography screening.

Methods: This is a descriptive, cross-sectional, population-based study conducted from October to March 2020 on over 35-year-old women living in Mashhad, selected through the convenient sampling method applied in health centers of Mashhad city. To measure the willingness to pay, the study participants were asked for their preferred choices concerning out-of-pocket payment for screening. Read More