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Asian Pac J Allergy Immunol 2022 May 22. Epub 2022 May 22.

Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.

Background: Assembly and budding in the late-stage of human immunodeficiency virus type 1 (HIV-1) production rely on Gag protein polymerization at the inner leaflet of the plasma membrane. We previously generated a monomeric ankyrin repeat protein (Ank1D4) that specifically interacts with capsid protein (CAp24) of HIV-1, however this protein had modest binding affinity.

Objective: This study aimed to improve the avidity of Ank1D4 by generating two Ank1D4 dimers: (Ank1D4NC-NC) and its inverted form (Ank1D4NC-CN), with each domain connected by a flexible (G4S)4 linker peptide. Read More

Asian Pac J Allergy Immunol 2022 May 22. Epub 2022 May 22.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Moisturizers play an important role in restoring the skin barrier. They should be used to treat and prevent eczema, especially in atopic dermatitis (AD).

Objective: To evaluate the factors that influence selection of moisturizers in adult patients with AD and without it. Read More

Asian Pac J Allergy Immunol 2022 May 22. Epub 2022 May 22.

Division of Nursing Services, Department of Pediatrics, Buddhasothorn Hospital, Chachoengsao, Thailand.

Background: Asthma control in Thai children is not yet satisfactory. Direct observation of the clinical practice for health care professionals (HCPs) in asthma clinic is essential.

Objective: To ascertain the implementation of asthma guidelines for Thai children, to assess the confidence level in general asthma management, and to determine the availability of medical supplies. Read More

Asian Pac J Allergy Immunol 2022 May 22. Epub 2022 May 22.

Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Background: Atopic dermatitis (AD) is a chronic disease that causes skin itching.

Objective: To investigate the effects of Scutellaria barbata D. Don (SBD) on AD-like symptoms induced by trimellitic anhydride (TMA) treatment in the ears of mice and its underlying mechanism. Read More

Asian Pac J Allergy Immunol 2022 May 22. Epub 2022 May 22.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Background: The diagnosis and management of patients with chronic rhinosinusitis (CRS) may vary between otolaryngologists and allergists. Moreover, the adherence of different practitioners to European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) 2020 guideline recommendations has not been previously ascertained in Asia-Pacific regions.

Objective: Different specialists' perceptions and managements of CRS in Asia-Pacific regions were assessed in an attempt to gauge these practices against EPOS 2020 guidelines. Read More

Asian Pac J Allergy Immunol 2022 May 22. Epub 2022 May 22.

Department of Pulmonology, Division of Allergy, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Univ Montpellier, France.

Background: Local anesthetics (LA) are widely used in medicine and are generally well tolerated. Although most adverse reactions are nonallergic, LA are a frequent reason for allergy consultation.

Objective: We want to expand the differential diagnosis of adverse reactions to LA by presenting rare diagnoses. Read More

Asian Pac J Allergy Immunol 2022 May 22. Epub 2022 May 22.

Department of Pathology, Prince of Songkla University Faculty of Medicine, Songkhla, Thailand.

Background: Nasal irrigation is an effective component of sino-nasal disease management. Nonetheless, bacterial contamination is worrisome.

Objective: To study bacterial colonization incidence using squeeze-bottle nasal irrigation devices, after disinfection with soap or soap-plus-microwave technique, in pediatric acute rhinosinusitis. Read More

Asian Pac J Allergy Immunol 2022 Mar 12. Epub 2022 Mar 12.

Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Cytokine-induced killer (CIK) cells are an ex vivo expanded heterogeneous population of natural killer (NK)-like T cells that can exert potent MHC-unrestricted antitumor activity. A number of pre-clinical and clinical studies have demonstrated that CIK cells can serve as a safe and potent immunotherapy of malignant tumors. N-acetylcysteine (NAC) has been demonstrated to enhance the T-cell functions by increasing their proliferation and cytokine production. Read More

Asian Pac J Allergy Immunol 2022 Mar 12. Epub 2022 Mar 12.

Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Exposure to particulate matter (PM) has been known to develop asthma in children and the oxidative stress-related mechanisms are suggested. For the development of asthma, not only the exposure dose but also the critical window and the risk modifying factors should be evaluated.

Objective: We investigated whether prenatal exposure to PM10 increases the risk of childhood asthma and evaluated the modifying factors, such as gender and reactive oxidative stress-related gene. Read More

Asian Pac J Allergy Immunol 2022 Mar 12. Epub 2022 Mar 12.

Department of Mental Health, Ningbo First Hospital, Ningbo, Zhejiang, China.

Background: Chronic cough has led to a substantial socioeconomic burden globally. Psychiatric comorbidities are reported in many chronic diseases. However, the relationship between mental disorders and chronic cough remains unclear. Read More

Asian Pac J Allergy Immunol 2022 Mar 12. Epub 2022 Mar 12.

Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital.

Background: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a distinctive syndrome characterized by unusual site thrombosis accompanied by thrombocytopenia following adenoviral vector vaccines against severe acute respiratory syndrome coronavirus 2. Platelet-activating anti-platelet factor 4-dependent antibodies (anti-PF4 Abs) have been identified as pathogenic antibodies in almost all patients.

Objective: We proposed an immunological mechanism of VITT independent of anti-PF4 Abs. Read More

Asian Pac J Allergy Immunol 2022 Mar 12. Epub 2022 Mar 12.

Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Daily intranasal corticosteroid (INCS) is recommended for treating allergic rhinitis (AR). Nevertheless, patients are generally not adherent and use it on-demand. The data on the efficacy of as-needed INCS was insufficient. Read More

Asian Pac J Allergy Immunol 2022 Mar 12. Epub 2022 Mar 12.

Near East University Hospital, Department of Pediatrics, Division of Allergy & Immunology, Nicosia, Cyprus.

Background: Allergen immunotherapy is the only currently available treatment strategy that modifies the immune response to the causative allergen and induces clinical improvement and a steroid-sparing effect.

Objective: In this real-life study, we aimed to evaluate and compare the efficacy of subcutaneous immunotherapy (SCIT) with one allergen or multiple allergens in children and adults with asthma and/or allergic rhinitis in terms of disease control and a steroid-sparing effect.

Methods: Demographics, the initial inhaled corticosteroid (ICS) and/or intranasal corticosteroid (INS) dose, and other drugs of patients receiving SCIT for at least 12 months were recorded. Read More

Asian Pac J Allergy Immunol 2022 Mar 12. Epub 2022 Mar 12.

Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: Leukotriene receptor antagonists are recommended to treat asthma and allergic rhinitis. Although they had been used for a long time, recent studies have reported neuropsychiatric adverse drug reactions are associated with montelukast.

Objective: This study analyzed the adverse drug reactions of montelukast and pranlukast, which are the two most frequently prescribed leukotriene receptor antagonists, respectively in Korea. Read More

Asian Pac J Allergy Immunol 2022 Mar 12. Epub 2022 Mar 12.

Department of Chest Diseases, Division of Immunology and Allergy, School of Medicine, Ankara University, Ankara, Turkey.

Background: Hymenoptera stings can cause systemic allergic reactions (SARs) that are prevented by venom immunotherapy (VIT). Sting challenge tests or field stings are used to evaluate the outcome of VIT.

Objective: The aim of the study was to investigate the consequences of field stings in patients during or after completion of VIT, and to identify patients at higher risk. Read More

Asian Pac J Allergy Immunol 2021 Dec;39(4):215-230

Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Objective: To report an overview of dermatologic adverse events (AEs) related to biologics used for psoriasis and compare common dermatologic AEs across different biologic classes.

Data Source: A comprehensive search in MEDLINE via PubMed from inception through June 9, 2021, was conducted.

Study Selection: The selection process was performed independently by two reviewers. Read More

Asian Pac J Allergy Immunol 2021 Dec 26. Epub 2021 Dec 26.

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Thailand.

Background: Melioidosis is an infectious disease caused by Burkholderia pseudomallei. In infected mice, IFN-γ can provide protection against B. pseudomallei infection. Read More

Asian Pac J Allergy Immunol 2021 Dec 26. Epub 2021 Dec 26.

Department of Otorhinolaryngology - Head and Neck Surgery, Meir Medical Center, Kfar Saba, Israel.

Background: Nivolumab, an immune checkpoint inhibitor is used to treat advanced metastatic malignancies. Data showed that nivolumab can cause exacerbated response of T-Helper 2 cells and lead to airway inflammation.

Objective: To present the upper airway findings of a 69-year-old woman after treatment with nivolumab. Read More

Asian Pac J Allergy Immunol 2022 Mar;40(1):1-21

Center of Excellence for Allergy, Asthma and Pulmonary Diseases, Department of Pediatrics, Thammasat University Hospital, Pathum Thani, Thailand.

The multidisciplinary experts in Thailand developed an asthma management recommendation that was relevant to low-middle income countries (LMICS). Populations level consideration about asthma management is emphasized. The healthcare systems, access to and availability of treatments as well as the asthma populations vary from country to country in LMICS. Read More

Asian Pac J Allergy Immunol 2021 Dec 26. Epub 2021 Dec 26.

Department of Respiratory Medicine, Kawasaki Medical School, Okayama, Japan.

Background: Interleukin (IL)-5 is essential for allergen induced eosinophilic airway inflammation, but not activation of T helper type 2 (Th2) cells in the lung. Although an excessive Th2 reaction is observed without IL-5 signaling, the mechanisms have remained unknown.

Objective: To evaluate the negative-feedback mechanism in eosinophilic airway inflammation, we examined IL-33 triggered eosinophilic airway inflammation in IL-5Rα-/- mice. Read More

Asian Pac J Allergy Immunol 2021 Dec 26. Epub 2021 Dec 26.

Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Air impurities can exacerbate or cause rhinologic diseases. However, only a few studies have assessed rhinologic patients' symptoms at work.

Objective: This study surveys the impact of work on rhinology clinic patients' quality of life in relation to work-related respiratory exposures. Read More

Asian Pac J Allergy Immunol 2021 Dec 26. Epub 2021 Dec 26.

Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Cutaneous manifestations of chronic spontaneous urticaria (CSU) are identical to type 1 hypersensitivity reactions. The daily occurrence of rash from occupational allergy could be misinterpreted as CSU exacerbation.

Objective: We aim to report a nurse with concomitant CSU suffering from latex-induced anaphylaxis. Read More

Asian Pac J Allergy Immunol 2021 Dec 26. Epub 2021 Dec 26.

The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of Sciences, Shanghai, China.

Background: Epithelial-to-mesenchymal transition (EMT) in nasal epithelial cells is involved in tissue remodeling of chronic rhinosinusitis with nasal polyps (CRSwNP). Our study investigated the molecular mechanisms that microRNA-182 (miR-182) regulated EMT in eosinophilic (Eos) and non-eosinophilic (non-Eos) CRSwNP.

Objective: To investigate the mechanism by which miR-182 regulates EMT in human nasal epithelial cells (hNEPCs). Read More

Asian Pac J Allergy Immunol 2021 Dec 26. Epub 2021 Dec 26.

>Hulhumale' Hospital Hulhumale', Maldives.

Background: The COVID-19 situation in Maldives have evolved since the epidemic began in March 2020 with unprecedented increase in cases since mid-July 2019 with over 8000 cases at the end of August 2020.

Objective: The aim of the sero-epidemiological investigation is to obtain a sense of the population exposure to the SARS-CoV-2 by measuring the seroprevalence of antibodies to COVID-19 in the general population.

Methods: A population-based, age-stratified prospective method was employed to find out the key epidemiological and serologic characteristics of COVID-19 virus in this study. Read More

Asian Pac J Allergy Immunol 2021 11 7. Epub 2021 Nov 7.

Showa University School of Medicine, Department of Medicine, Division of Respiratory Medicine and Allergology, Tokyo, Japan.

Background: Allergic bronchopulmonary aspergillosis (ABPA) is a severe type of asthma characterized by hypersensitivity to Aspergillus fumigatus and lung infiltration with eosinophilia. The central pathogenesis of asthma is airway hyperresponsiveness (AHR), with eosinophils playing a critical role. Anti-interleukin (IL)-5 antibody therapy has been recently introduced to treat severe asthma, which reportedly inactivates and reduces eosinophil count. Read More

Asian Pac J Allergy Immunol 2021 Oct 31. Epub 2021 Oct 31.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Alere™ HIV Combo is the only rapid and sensitive point-of-care 4th generation (antigen/antibody) HIV test newly available in Thailand which is advantageous of differentiating between positivity of antigen or antibody or both, especially in acute HIV infection (AHI). AHI in this study was defined by positive machine-based 4th generation test with measurable HIV-RNA but negative 3rd generation (IgM/IgG antibody only) tests.

Objective: To evaluate the performance characteristics of Alere™ HIV Combo. Read More

Asian Pac J Allergy Immunol 2021 Oct 31. Epub 2021 Oct 31.

Faculty of Medicine Rajavithi Hospital, Rangsit University, Bangkok, Thailand.

Background: Ocular Myasthenia Gravis (OMG) is an autoimmune disease which causes ptosis, diplopia, or both. There is very limited information on the presenting symptoms, treatment trends, factors influencing generalization, and treatment outcome in Thai populations.

Objective: To investigate characteristics of the presenting symptoms, associated factors for conversion to Generalized-MG (GMG), and treatment outcome in OMG patients. Read More

Asian Pac J Allergy Immunol 2021 Oct 31. Epub 2021 Oct 31.

Thai Red Cross Emerging Infectious Diseases Clinical Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Background: Inactivated SARS-CoV-2 (CoronaVac®, Sinovac, or SV) and ChAdOx1 nCoV-19 (Vaxzevria®, Oxford-Astra Zeneca, or AZ) vaccines have been administered to the health care workers (HCWs).

Objective: To determine the short-term immune response after the SV and AZ vaccinations in HCWs.

Methods: In this prospective cohort study, HCWs who completed a 2-dose regimen of the SV or AZ were included. Read More

Asian Pac J Allergy Immunol 2021 Oct 31. Epub 2021 Oct 31.

Immunology Division, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Knowledge of the prevalence of common sensitizing allergens may aid in overall management of allergic disease in a specified area.

Objective: The aim of this study was to identify and analyse the prevalence of common inhaled and food sensitizing allergens in Beijing.

Methods: This was a retrospective study, analysing demographic data and serum sIgE antibody test results from 59057 outpatients who presented to Beijing TongRen Hospital, from January 2013 to December 2019. Read More

Asian Pac J Allergy Immunol 2021 10 31. Epub 2021 Oct 31.

Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

Background: Knowledge of the prevalence of common sensitizing allergens may aid in overall management of allergic disease in a specified area.

Objective: The aim of this study was to identify and analyse the prevalence of common inhaled and food sensitizing allergens in Beijing.

Methods: This was a retrospective study, analysing demographic data and serum sIgE antibody test results from 59057 outpatients who presented to Beijing TongRen Hospital, from January 2013 to December 2019. Read More