10,495 results match your criteria Asian Pac. J. Cancer Prev.[Journal]


Secondhand Tobacco Smoke Exposure in Indoor Workplaces in Viet Nam and Associated Factors: Findings from Two Rounds of Global Adult Tobacco Surveys (GATS) 2010 and 2015.

Asian Pac J Cancer Prev 2020 Jul 1;21(S1):33-38. Epub 2020 Jul 1.

World Health Organization, Country Office for Viet Nam, Hanoi, Viet Nam.

Objectives: This paper explores changes in the level of secondhand smoke (SHS) exposure at indoor workplaces between 2010 and 2015 in Viet Nam and the association between the exposure and various demographic factors, using data from Viet Nam's Global Adult Tobacco Surveys (GATS) 2010 and 2015.

Methods: Data was pooled from the two GATS surveys and analysed using descriptive and Poisson regression analyses.

Results: There was a highly statistically significant reduction in the level of SHS exposure at indoor workplaces from 55. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.33DOI Listing

Raising Tobacco Taxes: The Philippine Experience.

Authors:
Jo-Ann L Diosana

Asian Pac J Cancer Prev 2020 Jul 1;21(S1):27-31. Epub 2020 Jul 1.

Action for Economic Reforms, Inc., Quezon City, Philippines.

The 2012 Philippine Sin Tax Reform Law or Republic Act No. 10351 (RA10351) offers important lessons on tobacco taxation and tobacco control. In a span of five years, it increased the excise tax rate on cigarettes to as high as 1000% for low-priced brands. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.27DOI Listing

Tobacco Industry Fingerprints on Delaying Implementation of Pictorial Health Warnings in the Western Pacific.

Asian Pac J Cancer Prev 2020 Jul 1;21(S1):23-25. Epub 2020 Jul 1.

Southeast Asia Tobacco Control Alliance, Bangkok, Thailand.

Objective: This case series describes tobacco industry tactics and strategies used to interfere, derail, delay, and weaken the development of effective health warning regulations in Malaysia, Cambodia, the Philippines, and Hong Kong.

Methods: A historical review of official reports, news articles, and gray literature was undertaken to identify tobacco industry tactics and strategies to hamper government efforts in implementing stronger pictorial health warning regulations in four Asian jurisdictions (Cambodia, Hong Kong, Malaysia, and the Philippines).

Results: Nineteen countries/jurisdictions in the WHO Western Pacific region currently require pictorial health warnings on cigarette packs, including some of the world's largest, in line with the WHO Framework Convention on Tobacco Control Article 11 Guidelines. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.23DOI Listing

Secondhand Smoke Exposure among Nonsmokers in China.

Asian Pac J Cancer Prev 2020 Jul 1;21(S1):17-22. Epub 2020 Jul 1.

National Cancer Institute, USA.

Background: China signed the World Health Organization Framework Convention on Tobacco Control and conducted a series of activities to protect people from secondhand smoke exposure. This paper explores the changes in prevalence of secondhand smoke exposure among nonsmokers between 2010 and 2015.

Methods: Data from the 2010 Global Adult Tobacco Survey and 2015 National Adult Tobacco Survey were used in this study. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.17DOI Listing

Investing in Tobacco Control: Twelve Years of MPOWER Measures and Progress in the Western Pacific Region.

Asian Pac J Cancer Prev 2020 Jul 1;21(S1):9-16. Epub 2020 Jul 1.

(Former) Division of NCD and Health though the Life-Course, World Health Organization Regional Office for the Western Pacific, Manila, Philippines.

Tobacco use has detrimental effects in the Western Pacific Region. The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) came into effect in 2005 to address the global tobacco epidemic, and WHO introduced the MPOWER measures to facilitate implementation of key demand-reduction measures of the WHO FCTC at the country level. This paper provides an overview of progress made by countries within the Region since the introduction of the MPOWER measures 12 years ago, and examines challenges and threats hindering their further implementation. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.9DOI Listing

Improving Information to Enable Effective Tobacco Control Intervention and Measure Progress Over Time: The Cambodia Country Experience.

Asian Pac J Cancer Prev 2020 Jul 1;21(S1):5-8. Epub 2020 Jul 1.

(Former) South East Asia Tobacco Control Alliance (SEATCA), Bangkok, Thailand.

Tobacco is a leading cause of noncommunicable diseases (NCDs) which kill about 41 million people each year. Of these, 15 million die prematurely between the ages of 30 and 69 years, most of which occur in low- and middle-income countries (LMICs). The adoption of the Sustainable Development Goals and their targets under the 2030 Agenda for Sustainable Development provides a new impetus for countries to accelerate tobacco control efforts as they specifically call for strengthening implementation of the World Health Organization (WHO) Framework Convention on Tobacco Control and striving to achieve a one-third reduction in premature deaths from NCDs. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.5DOI Listing

Making Strides Together against Tobacco Use.

Authors:
Takeshi Kasai

Asian Pac J Cancer Prev 2020 Jul 1;21(S1). Epub 2020 Jul 1.

World Health Organization Regional Office for the Western Pacific, UN Avenue corner Taft Avenue, Manila, Philippines.

In the Western Pacific Region, more than 3 million people die each year as a result of tobacco use - a problem for health and a threat to social and economic development. Countries around the world made a commitment by adopting the WHO Framework Convention on Tobacco Control of which implementation was then further facilitated by WHO's MPOWER package. Recognizing the importance of data as a powerful tool for tobacco control, this special supplement presents papers showcasing efforts by a number of Western Pacific countries and areas and data around these efforts to combat tobacco use and further advance progress in the battle against it. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.3DOI Listing

Integrated Bioinformatics Analysis of mRNAs and miRNAs Identified Potential Biomarkers of Oral Squamous Cell Carcinoma.

Asian Pac J Cancer Prev 2020 Jun 29;21(6):1841-1848. Epub 2020 Jun 29.

Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran.

Background: Oral cancer is a frequently encountered neoplasm of the head and neck region, being the eighth most common type of human malignancy worldwide. Despite improvement in its control, morbidity and mortality, rates have improved little in the past decades. The present investigations about gene interaction and pathways still could not clear the appearance and development of oral squamous cell carcinoma (OSCC), completely. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1841DOI Listing

Factors Associated with Time Intervals for Diagnosis of Colorectal Cancer: A Hospital Based Study in Khon Kaen, Thailand.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1835-1840. Epub 2020 Jun 1.

ASEAN Cancer Epidemiology and Prevention Research Group (ACEP), Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.

Background: Colorectal cancer (CRC) is among the five-leading cancers in Thailand. Delayed diagnosis is crucial for undermining the prognosis of the patients. This study aims to evaluate the factors associated with the time interval for diagnosis (TID). Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1835DOI Listing

Serum Folate Levels and Lung Cancer Risk: A Meta- Epidemiological Study of Population-based Case-Control Studies.

Authors:
Jong-Myon Bae

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1829-1833. Epub 2020 Jun 1.

Department of Preventive Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea.

Objective: While it has been claimed that lung cancer occurs due to epigenetic mechanisms, four systematic reviews were reported to investigate the association between serum folate levels and lung cancer risk. Considering some methodological problems founded in the systematic review, a meta-epidemiological study was conducted.

Methods: The selection criteria of this study were defined that a case-control study was conducted to determine the risk of lung cancer occurrence according to the concentration of serum folate and its results showed odds ratio and its 95% confidence interval. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1829DOI Listing

Investigation of the Effect of Zebularine in Comparison to and in Combination with Trichostatin A on p21Cip1/Waf1/ Sdi1, p27Kip1, p57Kip2, DNA Methyltransferases and Histone Deacetylases in Colon Cancer LS 180 Cell Line.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1819-1828. Epub 2020 Jun 1.

Research Center for Non-communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: The heart of the cell cycle regulatory machine is a group of enzymes named cyclin-dependent kinases (Cdks). The active form of these enzymes includes a kinase and its partner, a cyclin. The regulation of cyclin-Cdk complexes is provided by Cdk inhibitors (CKIs) such as Cip/Kip family comprising p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1819DOI Listing

Effect of a Pedometer-based Exercise Program on Cancer Related Fatigue and Quality of Life amongst Patients with Breast Cancer Receiving Chemotherapy.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1813-1818. Epub 2020 Jun 1.

Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.

Background: Breast cancer is the most common cancer amongst Indian women. Cancer treatments leads to various side effects out of which Cancer-Related fatigue (CRF) is one of the most under-addressed side-effects. It is experienced the most in patients receiving chemotherapy. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1813DOI Listing

Randomized Pilot Study of 20 Gy in 5 Fractions versus 27 Gy in 3 Fractions Radiotherapy for Treating Painful Bone Metastases: A Single Institution Experience.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1807-1811. Epub 2020 Jun 1.

Department of Clinical Oncology, Kasr Al-Einy School of Medicine, Cairo University, Egypt.

Purpose: Radiotherapy is a very effective tool in the treatment of painful bone metastases. The aim of this study was to compare the palliative effect of radiotherapy between the standard fractionation schedule 20 Gy over 5 fractions (20Gy/5fr) and the high biological dose schedule 27 Gy over 3 fractions (27Gy/3fr) which is frequently used in Stereotactic body radio-surgery (SBRT).

Methods: Patients were randomized to receive (20Gy/5fr)or (27Gy/3fr). Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1807DOI Listing

The Prognosis of Hepatocellular Carcinoma Treated with Sorafenib in Combination with TACE.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1797-1805. Epub 2020 Jun 1.

Division of Gastroenterology and Hepatology, Department of Internal Medicine (Omori), School of Medicine, Faculty of Medicine, Toho University 6-11-1 Omorinishi, Ota-ku, Tokyo, 143-8541 Japan.

Objective: Sorafenib have been shown to be effective in the treatment of advanced HCC and has been standard therapy since its release in Japan in 2009 (Llovet et al., 2008; Cheng et al., 2009). Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1797DOI Listing

Risk Scoring System based on lncRNA Expression for Predicting Survival in Hepatocellular Carcinoma with Cirrhosis.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1787-1795. Epub 2020 Jun 1.

Department of Immunology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, China.

Objective: This study aims to explore the roles of long non-coding RNAs (lncRNAs) for predicting survival in hepatocellular carcinoma (HCC) patients with cirrhosis.

Methods: A set of lncRNAs differentially expressed between HCC patients with or without cirrhosis was identified using expression profiles of The Cancer Genome Atlas database, and these lncRNAs were screened for their risk scoring system to predict recurrence-free survival (RFS) or overall survival (OS). Predictive ability of risk scoring systems was confirmed using uni- and multivariate Cox analyses while adjusting for clinical features. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1787DOI Listing

Mortality from Selected Cancers among Brazilian Mechanics.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1779-1786. Epub 2020 Jun 1.

Occupational and Environmental Health Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Introduction: Mechanics are exposed to known human carcinogens. This study aimed to compare mortality from selected cancers between male mechanics and the general population of the South and Southeast regions of Brazil.

Methods: Data on deaths, occurred between 2006-2017, among male mechanics and the general population, were obtained from the Mortality Information System. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1779DOI Listing

Hsp90 Inhibitor; NVP-AUY922 in Combination with Doxorubicin Induces Apoptosis and Downregulates VEGF in MCF-7 Breast Cancer Cell Line.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1773-1778. Epub 2020 Jun 1.

Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.

Objective: Breast cancer is one of the most prevalent malignancies and leading causes of females' mortality worldwide. Because of resistance to various treatment options, new treatments based on molecular targeting has introduced as noticeable strategies in cancer treatment. In this regard, heat shock protein 90 (Hsp90) inhibitors are proposed as effective anticancer drugs. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1773DOI Listing
June 2020
1.500 Impact Factor

Methylene Blue Absorption in Sentinel Lymph Node Biopsy for Early Breast Cancer after Neoadjuvant Chemotherapy.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1767-1771. Epub 2020 Jun 1.

Department of Surgery, Digestive Division, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia.

Introduction: Chemotherapy is claimed to cause lymphatic drainage damage because of the tumor cell's apoptosis process. This event might cause decreased marker (radioactive solution and/or blue dye) absorption on sentinel lymph nodes (SLN). In this study, the researchers used methylene blue only and wished to evaluate the methylene blue absorption of the SLNB procedure on early-stage breast-cancer patients after neoadjuvant chemotherapy (NAC). Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1767DOI Listing

Age-Period-Cohort Analysis of the Sex Differences in Cancer Mortality Rates in Japan from 1995 to 2015.

Authors:
Tasuku Okui

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1759-1765. Epub 2020 Jun 1.

Medical Information Center, Kyusyu University Hospital, Fukuoka city, Japan.

Background: The current study aimed to analyze the sex differences in cancer mortality rates in Japan via an age-period-cohort (APC) analysis.

Methods: We used data about cancer mortality rates from 1995 to 2015 in Japan based on the Vital Statistics survey. In addition to the data about mortality from all sites of cancer, we specifically used data about stomach, lung, colorectal, and liver cancers. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1759DOI Listing

Prophylactic Chemotherapy with Methotrexate Leucovorin in High-Risk Hydatidiform Mole.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1755-1758. Epub 2020 Jun 1.

Department of Gynecology and Oncology, Iran University of Medical Sciences, Tehran, Iran.

Aim: Gestational Trophoblastic Neoplasia (GTN) is used to describe a group of malignant gestational tumors originating from the placenta. The chance of having malignant GTN is high in a high-risk molar pregnancy. The main aim of this study is to investigate the effectiveness of using prophylactic chemotherapy in high-risk molar pregnancy to prevent malignant GTN. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1755DOI Listing

MiRNA-7 Replacement Effect on Proliferation and Tarceva-Sensitivity in U373-MG Cell Line.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1747-1753. Epub 2020 Jun 1.

Department of Anatomy, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Background: Deregulation of the EGFR signaling pathway activity has been shown to can be effective in resistance to EGFR-TKIs, such as Tarceva (erlotinib), in glioblastoma cells. In addition, reports have shown that the reduction of miRNA-7 expression levels is associated with an increase in the expression of EGFR. Here, we evaluated the effect of miRNA-7 on EGFR expression and sensitivity of the U373-MG glioblastoma to erlotinib. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1747DOI Listing

Microarray Analysis of Gene Expression Involved in Butyrate-Resistant Colorectal Carcinoma HCT116 Cells.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1739-1746. Epub 2020 Jun 1.

Department of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.

Background: Resistance to chemotherapeutic agents is usually found in cancer stem cells (CSCs) and cancer stem-like cells that are often regarded as the target for cancer monitoring. However, the different patterns of their transcriptomic profiling is still unclear.

Objective: This study aims to illustrate the transcriptomic profile of CSCs and butyrate-resistant colorectal carcinoma cells (BR-CRCs), by comparing them with parental colorectal cancer (CRC) cells in order to identify distinguishing transcription patterns of the CSCs and BR-CRCs. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1739DOI Listing

Effect of Hip Prosthesis on Photon Beam Characteristics in Radiological Physics.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1731-1738. Epub 2020 Jun 1.

Division of Medical Physics and Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi (India)-110085, India.

Introduction: Aim of study is to investigate the effect of hip prosthesis on 6 and 15 MV photon beam energies.

Materials And Methods: Prosthesis was kept at the level of tray position. The measurements were done on Varian Clinac-iX linac. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1731DOI Listing

Driving to Childhood Cancer Hub Hospitals: A Study on Hospital Accessibility in Japan.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1725-1730. Epub 2020 Jun 1.

Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Japan.

Objective: In 2013, 15 childhood cancer hub hospitals in Japan were designated to provide quality medical treatment and care. The present study assessed hospital accessibility by investigating travel times and distances from patient residences.

Methods: A total of 37,309 residence/hospital pairs were generated using the addresses of 15 hub hospitals that were designated in 2019 and local government offices in 2014. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1725DOI Listing

Neoadjuvant FOLFIRINOX followed by Chemoradiotherapy for Middle and Lower Rectal Cancer.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1717-1723. Epub 2020 Jun 1.

Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine (NEMROCK), Faculty of Medicine, Cairo University, Egypt.

Objective: Neoadjuvant concomitant chemoradiotherapy followed by surgical resection is the standard of care in the treatment of rectal cancer. We are investigating the value of adding combination chemotherapy oxaliplatin, irinotecan, leucovorin and fluorouracil (FOLFIRINOX) before neoadjuvant chemoradiotherapy.

Methods: Forty-one patients with middle and lower rectal cancer were included. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1717DOI Listing

Synergistic Effect of Benzethonium Chloride Combined with Endoxan against Hepatocellular Carcinoma in Rats through Targeting Apoptosis Signaling Pathway.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1709-1716. Epub 2020 Jun 1.

Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Egypt.

Combination therapy has been the trendy of care, particularly in cancer remedy, since it is a rational approach to increase response and tolerability and to diminish resistance. Hence, there is a growing interest in combining anticancer drugs to maximizing efficacy with minimum systemic toxicity through the delivery of lower drug doses. Therefore, in the present study, the value of combination between benzethonium chloride (benzo) and endoxan (endo) as anti-tumor drug sensitization of hepatocellular carcinoma HCC treatment were detected both in vitro and in vivo. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1709DOI Listing

Intake of Common Alcoholic and Non-Alcoholic Beverages and Breast Cancer Risk among Japanese Women: Findings from the Japan Collaborative Cohort Study.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1701-1707. Epub 2020 Jun 1.

Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

This study investigated the association between intake of common alcoholic and non-alcoholic beverages and breast cancer risk among Japanese women. This study included 33,396 Japanese women aged 40-79 years from 24 areas in Japan from the Collaborative Cohort study. During the follow-up period (≥20 years), 245 incidents or mortal breast cancers were documented. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1701DOI Listing

Predictors of the Onset of Type 1 Diabetes Obtained from Real-World Data Analysis in Cancer Patients Treated with Immune Checkpoint Inhibitors.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1697-1699. Epub 2020 Jun 1.

Department of Pharmacy, National Hospital Organization Hokkaido Cancer Center, Japan.

Medications that target programmed cell death protein-1 (PD-1) have proven effective. However, blockade of PD-1/Programmed death-ligand 1(PD-L1) causes immune-related adverse events (irAEs). Characteristics of this irAE include many symptom, low in frequency, and difficulty in prevention. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1697DOI Listing

Clinical Potentials of miR-576-3p, miR-613, NDRG2 and YKL40 in Colorectal Cancer Patients.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1689-1695. Epub 2020 Jun 1.

Department of Biochemistry, Faculty of Science, Helwan University, Cairo, Egypt.

Introduction: Colorectal cancer (CRC) is the most common type of gastrointestinal tract cancers. This investigation aim was to assess the expression of miR-576-3p and miR-613 in CRC patients in addition to NDRG2 and YKL40 serum levels determination to decide their diagnostic and prognostic significance.

Methods: Sixty early diagnosed CRC patients prior to any treatment in addition to twelve healthy subjects were enrolled in this study. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1689DOI Listing

Characteristics and Impact of HPV-Associated p16 Expression on Head and Neck Squamous Cell Carcinoma in Thai Patients.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1679-1687. Epub 2020 Jun 1.

Division of Medical Oncology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy in Asia. Infection by human papilloma virus (HPV) has been recognized as an etiological risk for HNSCC, especially oropharyngeal region. While the association between HPV and HNSCC has been well evaluated in Western countries, only a few investigated the HPV-associated HNSCC in Southeast Asia. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1679DOI Listing

Diagnostic delay for head and neck cancer in South India: A Mixed-methods Study.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1673-1678. Epub 2020 Jun 1.

Department of ENT, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Early diagnosis is an important aspect of quality of cancer care.Analysis of the diagnostic delays and the reasons for delay helps to plan strategies to improve cancer care.

Objectives: To determine the primary, secondary, and total diagnostic delay of patients diagnosed with head and neck cancer and to explore the reasons for the delay from the patient perspective. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1673DOI Listing

Health Promoting Lifestyle and its Relationship with Self-Efficacy in Iranian Mastectomized Women.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1667-1672. Epub 2020 Jun 1.

Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Lifestyle modification has an important role in long-term health of breast cancer patients. As a result, this study aimed to identify the health-promoting lifestyle and its subdomains in mastectomized women and its relationship with self-efficacy.

Materials And Methods: This cross-sectional study investigated 100 mastectomized women in Tabriz-Iran, 2018. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1667DOI Listing

Dosimetric Validation of Digital Megavolt Imager for Flattening Filter Free Beams in the Pre-Treatment Quality Assurance of Stereotactic Body Radiation Therapy for Liver Metastases.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1659-1665. Epub 2020 Jun 1.

Department of Radiation Oncology, Apollo Cancer Institute, Chennai, Tamilnadu, India.

Aim: The aim is to evaluate the use of digital megavolt imager (DMI) aS1200 in portal dosimetry with flattening filter free (FFF) beams.

Materials And Methods: Dosimetric properties of DMI is characterized at 6MV FFF beams for signal saturation, dose linearity, dependency on dose-rate and source-detector distance (SDD), signal lag (ghosting), and back scatter.  Portal dosimetry is done for twenty volumetric modulated arc therapy (VMAT) based stereotactic body radiotherapy (SBRT) plans for the treatment of liver metastases and the results are compared with repeated measurements of Octavius 4D. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1659DOI Listing
June 2020
1.500 Impact Factor

Conflict of Interest: Are Iranian Breast Cancer Specialists Prone to it?

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1653-1658. Epub 2020 Jun 1.

Department of Surgery, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Introduction: Giving gifts is a common way to promote and encourage the use of products of trading companies and increase the patient referrals to diagnostic centers. The present study aimed to assess the practice of physicians of different (sub) specialties/educational levels engaged in breast cancer management in some conflict of interest (COI) situations in their relation with pharmaceutical companies and paraclinical centers.

Methods: A self-administered online questionnaire including questions on demographic and professional information as well as the attitude of physicians toward COI by answering the questions in three different practical scenarios was developed. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1653DOI Listing

Gastric Cancer in Aktobe Region of Western Kazakhstan from 2009 to 2018: Incidence Rates, Trends, and Five-Year Survival.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1645-1652. Epub 2020 Jun 1.

Tbilisi State Medical University, 33, Vazha-Pshavela Ave., Tbilisi, Georgia.

Objective: to assess the current state of gastric cancer (GC) incidence and its five-year survival across Aktobe region of western Kazakhstan from 2009 to 2018 by presenting key indicators and analyzing the most significant features.

Methods: Rough incidence rates (per 100,000) and average annual percent changes (aAPCs) were estimated for each age group at diagnosis with respect to gender, ethnicity, residence, the disease stages, tumor subsite, and histology type using linear regression analysis, including the prognostic index for 2019-2020. Overall five-year survival rates were estimated by the Kaplan-Meier method. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1645DOI Listing

Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1637-1644. Epub 2020 Jun 1.

Department of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.

Background/aim: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1637DOI Listing

Sentinel Node Biopsy in Early Breast Cancer Patients with Palpable Axillary Node.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1631-1636. Epub 2020 Jun 1.

School of Medicine, Student Research Committee of Mazandaran University of Medical, Sari, Iran.

Background: Sentinel lymph node biopsy is a reliable method for evaluation of the axillary lymph node status in early stage breast cancer patients with non-palpable lymph nodes. The present study evaluated the status of sentinel and non-sentinel lymph nodes in T1T2 patients with palpable axillary lymph nodes.

Materials And Methods: One hundred and two women with early breast cancer were investigated in this study. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1631DOI Listing

Associations of the -238(G/A) and -308(G/A) TNF-α Promoter Polymorphisms and TNF-α Serum Levels with the Susceptibility to Gastric Precancerous Lesions and Gastric Cancer Related to Helicobacter pylori Infection in a Moroccan Population.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1623-1629. Epub 2020 Jun 1.

Helicobacter Pylori and Gastric Pathologies Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.

Objective: Helicobacter pylori (H. pylori) induces the production of tumor necrosis factor-alpha (TNF-α), which is closely related to a gastric epithelial injury. TNF-α gene polymorphism and TNF-α serum levels are associated with various malignant conditions. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1623DOI Listing

The Ominous beginning" Perceptions of Smokeless Tobacco Initiation among the Paniya Tribes of Wayanad: A qualitative Study.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1615-1622. Epub 2020 Jun 1.

Department of Public Health Dentistry, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Background: The prevalence of tobacco chewing, and related oral mucosal lesions is alarmingly high amongst the Paniya tribes of Wayanad. A deeper understanding of their socio-cultural factors, beliefs, attitudes and behaviours would shed greater insights into the indiscriminate use of smokeless tobacco and related products in this community.

Methods: Ethnography was the theoretical framework adopted with network and convenience sampling. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1615DOI Listing
June 2020
1.500 Impact Factor

The Expression of p53, CD44, Ki-67, and HER-2/neu Markers in Gastric Cancer and Its Association with Histopathological Indicators: A Retrospective Study.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1607-1614. Epub 2020 Jun 1.

Department of Biology, University of Toronto, Toronto, Canada.

Background And Objectives: Gastric cancer is known as one of the most common cancers and causes of deaths. Early and proper diagnosis is one of the most important things for treatment response. Therefore, this study aimed to determine the expression of p53, CD44, Ki-67, and HER-2/neu markers in the gastric cancer and its relationship with histopathological indicators. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1607DOI Listing

Natural Killer Cells Expanded and Preactivated Exhibit Enhanced Antitumor Activity against Different Tumor Cells in Vitro.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1595-1605. Epub 2020 Jun 1.

Department of Medical Lab Technology, Faculty of Applied Medical Sciences, Prince Fahd Bin Sultan Research chair, University of Tabuk, Saudi Arabia.

One of the emerging treatment strategies for cancer particularly for haematological malignancies is natural killer (NK) cell therapy. However, the availability of a best approach to maximize NK cell anticancer potential is still awaited. It is well established that cytokine-induced memory-like NK cells have the potential to differentiate after a short period of preactivation with interleukins-IL-12, IL-15, and IL-18 and exhibit increased responses to cytokine or activating receptor restimulation for weeks to months after preactivation. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1595DOI Listing

Associations of Single Nucleotide Polymorphism in miR-146a Gene with Susceptibility to Breast Cancer in the Iranian Female.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1585-1593. Epub 2020 Jun 1.

Department of Genetic, Collage of Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.

Background: MicroRNAs (miRNAs), short regulatory RNAs, function as negative regulators able to modulate gene expression. Just as other genetic variant, single nucleotide polymorphisms (SNPs) in miRNA genes, may have an impact on their expression and/or maturation and hence leading to different consequences in carcinogenesis. Accordingly, this study aimed to assess the frequency of miR-146a G/C (rs2910164) polymorphism and its association with susceptibility to breast cancer in Iranian women. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1585DOI Listing

Assessing CD 10 Expression Level and Its Prognostic Impact in Egyptian Patients with Urothelial Carcinoma.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1573-1583. Epub 2020 Jun 1.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background And Aim: CD10 is expressed in urothelial carcinoma cells and cancer associated fibroblasts (CAF). In the current study, CD10 immunohistochemical staining (IHC) and CD10 mRNA expression in urothelial carcinoma of bladder (UCB) were assessed, and its  relationship with tumor progression and prognosis was investigated.

Patients And Methods: In this study, 106 formalin fixed paraffin-embedded (FFPE) tissue of UCB, obtained through radical cystectomy specimen, and 10 matched normal tissue samples were included. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1573DOI Listing

Adherence to ASCO for Prophylaxis of Acute Chemotherapy- Induced Nausea and Vomiting in Iran.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1567-1572. Epub 2020 Jun 1.

Department of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Chemotherapy-induced nausea and vomiting (CINV) is one of the scariest chemotherapy-induced adverse effects. We evaluated the adherence to the 2017 American Society of Clinical Oncology (ASCO), the latest guideline recommendations, for the management of acute CINV at our institute.

Methods: During a 6-months cross-sectional study on outpatient's cancer patients, we collected data from the prescription documents during temporary hospitalization and compared the results with ASCO guideline recommendations. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1567DOI Listing

The Case to Case Comparison of Hormone Receptors and HER2 Status between Primary Breast Cancer and Synchronous Axillary Lymph Node Metastasis.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1559-1565. Epub 2020 Jun 1.

Department of Surgery, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.

Background: Nowadays, the adjuvant treatment for breast cancer patients chosen depends on immunohistochemical pattern of Estrogen receptor(ER), Progesterone receptor(PR) and HER2 status of primary breast tumor. Several retrospective studies showed significant discordance in receptor expression between primary and metastatic tumors. The objective of this research was to determine discordant rate of ER, PR and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis of individual breast cancer patients in Thammasat University Hospital. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1559DOI Listing

A Study of Ser217Leu and Ala541Thr Polymorphism in the Men Afflicted with Prostate Cancer and in the Men being Suspicious of Prostate Cancer.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1551-1557. Epub 2020 Jun 1.

Department of Genetics scholar Biology sciences Islamic Azad university of Tonekabon Branch, Tonekabon, Iran.

Background And Objective: Prostate cancer is one of the most widespread cancers among men throughout the world. In addition, it is the second cause of death after lung cancer. Occurrence of the prostate cancer is variable in various regions of the world. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1551DOI Listing

BCR-ABL Gene Transcript Types of Patients with Chronic Myelogenous Leukemia in Yogyakarta, Indonesia.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1545-1550. Epub 2020 Jun 1.

Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/ Dr Sardjito General Hospital, Yogyakarta, Indonesia.

The aim of this study was analyzing the BCR-ABL transcript types of patients with chronic myeloid leukemia (CML) in Dr Sardjito General Hospital, Yogyakarta, Indonesia. This study is very relevant because the data concerning BCR-ABL gene transcript types is very limited in Indonesia. Furthermore, it is important for patient's management, particularly in defining the tyrosine kinase inhibitors (TKIs) therapy and monitoring after therapy. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1545DOI Listing

Analyzing Survival Rate of Leukemia Patients Applying Long Term Exponential Model.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1539-1543. Epub 2020 Jun 1.

Physiotherapy Research Center, Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Making progressin treatment of all branches of cancers has increasedthe percent of patients that never experience the event of interest. These cases are called immune or cure and models for handling the data included cure fraction rate, are referred to as cure model or long-term survival models.

Methods: The data for this historical cohort study, were collected from leukemia patients diagnosed between 2007 to 2014 and followed up until 2016 in Taleghani hospital and received BMT (Bone Marrow Transplant). Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1539DOI Listing

Dispersive Micro-Solid Phase Extraction for Sensitive Determination of Methotrexate from Human Saliva Followed by Spectrophotometric Method.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1531-1538. Epub 2020 Jun 1.

Department of Organic Chemistry, Azarbaijan Shahid Madani University, Tabriz, Iran.

For biological assessing of hospital personnel occupationally exposed to antineoplastic drugs, highly sensitive and accurate methods are required. Methotrexate (MTX) is an anticancer agent that is widely used in a variety of human cancers. For the first time, dispersive-micro solid phase extraction (D-µ-SPE) has been applied for determination of low levels of MTX in saliva samples. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1531DOI Listing

Do Subjective Norms Predict the Screening of Cancer Patients' First-Degree Relatives? A Systematic Review and Meta-Analysis.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1521-1530. Epub 2020 Jun 1.

Department of Health Eduacation, Faculty of public health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Early detection and preventive measures can reduce the risk of cancer among first degree relatives (FDRs) of cancer patients.Several studies investigated the effect of subjective norm in relation to FDRs' tendency to conduct preventive behaviors. Therefore, the purpose of this study was to systematically evaluate the effect of subjective norms on cancer patients' FDRs as well as their willingness for screening. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1521DOI Listing