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Asian J Endosc Surg 2022 May 18. Epub 2022 May 18.

Department of Gastroenterological Surgery, Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan.

A 66-year-old man underwent laparoscopic low anterior resection for rectal cancer. A transanal decompression tube (24Fr Nelaton catheter) was placed laparoscopically during the surgery. Contrast enema on postoperative day 5 showed perforation of the sigmoid colon around the tip of the tube, and emergency laparotomy was performed. Read More

Chem Asian J 2022 May 18. Epub 2022 May 18.

Research Centre for Natural Sciences: Termeszettudomanyi Kutatokozpont, Institute of Organic Chemistry, Magyar Tudósok krt, 1117, Budapest, HUNGARY.

Due to the increasing relevance of fluorine-containing organic molecules in drug design, the synthesis of organofluorine compounds has gained high significance in synthetic organic chemistry. Trifluoromethylative difunctionalizations of carbon-carbon multiple bonds, with the simultaneous incorporation of a CF 3 group and another functional element, have considerable potential. Because of the high importance of carbon-carbon bond-forming reactions in organic synthesis, carbotrifluoromethylations and, in particular, aryltrifluoromethylations or heteroaryltrifluoromethylations are considered to be increasing fields of synthetic organic chemistry. Read More

Mil Med 2022 May 18. Epub 2022 May 18.

Mental Health Service, San Francisco VA Health Care System, San Francisco, CA 94121, USA.

Introduction: Veterans in general-and especially those who identify as Veterans of color-are underrepresented in health-related treatment research. This contributes to health inequity by hindering the development of evidence-based treatment recommendations for people of color. This project utilized culturally centered research procedures to identify health-related research priorities and examine motives for and barriers to research participation in a diverse sample of Veterans. Read More

PLoS One 2022 18;17(5):e0268617. Epub 2022 May 18.

Sylvester Comprehensive Cancer Center, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

Background: Postmenopausal breast cancer (PMBC) is the most commonly diagnosed and the second leading cause of cancer death among women in the US. Research examining the association between PMBC and education level has been inconsistent; no study in the US has examined how educational level impacts PMBC mortality in Asian American women, a largely immigrant population with above-average educational attainment.

Methods: California Vital Statistics data from 2012-2017 were analyzed to derive age-adjusted mortality rate ratios (MRRs) by education level (associates degree or above referred to as "higher education", high school, less than high school) and race [Non-Hispanic White (NHW), Asian/Pacific Islander (Asian), and its two largest subpopulations: Chinese and Filipino] from negative binomial regression models. Read More

Dermatol Surg 2022 May 17. Epub 2022 May 17.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China.

Background: The frontal-temporal triangle area (FTTA) hair has a slow growth rate and thin caliber, which are similar to those of eyebrow hair. However, a comparison of cosmetic outcomes between FTTA and other scalp hair grafts in eyebrow transplantation has not been performed.

Objective: To compare the cosmetic outcomes of FTTA hair and periauricular and occipital area (POA) hair in eyebrow restoration. Read More

JAMA Netw Open 2022 May 2;5(5):e2213337. Epub 2022 May 2.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology at Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Importance: Pervasive gender disparities exist in medicine regarding promotion, achievement of academic rank, and appointment to leadership positions. Fertility and childbearing concerns may contribute to these disparities.

Objective: To assess fertility knowledge and concerns and evaluate barriers to family building and impact on academic attrition reported by female physicians. Read More

Neurol Sci 2022 May 18. Epub 2022 May 18.

Department of Neurology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, China.

In 2018, the first list of rare diseases was published by the National Health Council of China, and multiple sclerosis (MS) was included in this list. Since then, the Chinese government and neurologists have made efforts to improve the clinical outcomes of patients with MS. During last few years, the incidence of MS in China was also investigated. Read More

Gerontologist 2022 May 18. Epub 2022 May 18.

Institute for Health, Health Care Policy and Aging Research, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.

Background And Objectives: Studies have shown that neighborhood environment shapes older Americans' aging experience and health. However, it remains largely unknown whether and how neighborhood environment influences the wellbeing of older Asian Immigrants. Guided by the neighborhood stress process model, this study aims to investigate 1) the associations between neighborhood environmental stressors and depression among Chinese older immigrants, and 2) the potential mediation effects of intrapersonal (sense of mastery, sense of hopefulness) and interpersonal coping (social engagement) resources in such associations. Read More

Phys Chem Chem Phys 2022 May 18. Epub 2022 May 18.

State Key Laboratory of Superhard Materials, College of Physics, Jilin University, Changchun 130012, P. R. China.

KSiH exhibits 4.1 wt% experimental hydrogen storage capacity and shows reversibility under moderate conditions, which provides fresh impetus to the search for other complex hydrides in the K-Si-H system. Here, we reproduce the stable 3̄ phase of KSiH and uncover two denser phases, space groups 3̄1 and 6 at ambient pressure, by means of first-principles structure searches. Read More

J Genet Psychol 2022 May 18:1-16. Epub 2022 May 18.

UCSI University, Kuala Lumpur, Malaysia.

Although parental warmth has been shown to be related to children's social competence, the mediating role of preadolescent children's emotion regulation in this context has been less explored, particularly in Asian cultures. Thus, this study examined the role of emotion regulation as a mediator in the relationship between parental warmth (i.e. Read More

J Am Heart Assoc 2022 May 18:e025050. Epub 2022 May 18.

Division of Cardiology Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL.

Background Adverse pregnancy outcomes (APOs) (hypertensive disorders of pregnancy [HDP], preterm delivery [PTD], or low birth weight [LBW]) are associated adverse maternal and offspring cardiovascular outcomes. Therefore, we sought to describe nationwide temporal trends in the burden of each APO (HDP, PTD, LBW) from 2007 to 2019 to inform strategies to optimize maternal and offspring health outcomes. Methods and Results We performed a serial cross-sectional analysis of APO subtypes (HDP, PTD, LBW) from 2007 to 2019. Read More

Chem Asian J 2022 May 18. Epub 2022 May 18.

Sichuan University West China Hospital of Stomatology: Sichuan University West China College of Stomatology, West China Hospital of Stomatology, CHINA.

Photothermal therapy (PTT) has drawn extensive attention owing to its noninvasive and great tissue penetration depth. However, the physical encapsulation of photothermal agents may lead to their rapid release. Dual-functional hydrogel systems that integrate functions and carriers can potentially solve this problem. Read More

J Asian Nat Prod Res 2022 May 18:1-9. Epub 2022 May 18.

Qinzhou Provincial Health School, Qinzhou 535000, China.

Amestolkins A () and B (), two previously undescribed phthalides sharing the same planar structure of (1, 5-dihydroxyhexyl)-7-hydroxyisobenzofuran-1(3)-one were isolated from . Their absolute configurations were elucidated by comprehensive analyses of spectroscopic evidences in high-resolution electrospray mass spectra (HRESIMS) and nuclear magnetic resonance (NMR) combined with electronic circular dichroism (ECD) and NMR calculations. and showed anti-neuroinflammatory activity by inhibiting the gene expressions of proinflammatory factors including C-C motif chemokine ligand 2 (CCL-2), tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), as well as attenuating the excretion of inducible nitric oxide synthase (iNOS) in BV-2 microglial cells at the concentration of 30 μM. Read More

Chem Asian J 2022 May 17. Epub 2022 May 17.

Northeast Normal University, Faculty of Chemistry, 7989 Weixing Road, 130022, Changchun, CHINA.

Nitrogen doped carbon materials containing transition metal nanoparticles have attracted much attention as bifunctional oxygen electrocatalysts. In this paper, the template etching method is used to obtain the nitrogen-doped graphene with abundant macropores embedded with cobalt nanoparticles ([email protected]). The prepared [email protected] catalyst has a half-wave potential (E 1/2= 0. Read More

Asian J Pharm Sci 2022 Mar 25;17(2):230-240. Epub 2022 Feb 25.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China.

Recently, the highly ordered J-aggregates of organic dyes with intriguing optical properties have received considerable attention in biomedical applications. Herein, binary metal ions Mn(II)/Fe(III) are used to induce the formation of indocyanine green (ICG) J-aggregates. Further, the sheet-like J-aggregates are able to act as "carriers" for loading hydrophobic chemotherapeutic gambogic acid (GA), realizing the effect of "killing two birds with one stone" for both treatment and delivery. Read More

Asian J Pharm Sci 2022 Mar 27;17(2):241-252. Epub 2022 Feb 27.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

PEGylation has been widely used to improve the pharmacokinetic properties of prodrug self-assembled nanoparticles (prodrug-SANPs). However, the impacts of the amount of PEG on the self-assemble stability, cellular uptake, pharmacokinetics, and antitumor efficacy of prodrug-SANPs are still unknown. Herein, selenoether bond bridged docetaxel dimeric prodrug was synthesized as the model prodrug. Read More

Asian J Pharm Sci 2022 Mar 4;17(2):193-205. Epub 2022 Jan 4.

School of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, China.

As an important means of communication among cells, exosomes are being studied more and more widely, especially in the context of cancer immunotherapy. In the phase of tumor immunoediting, exosomes derived from tumor cells and different immune cells have complex and changeable physiological functions, because they carry different proteins and nucleic acid from the source cells. Based on the role of exosomes in the communication between different cells, cancer treatment methods are also under continuous research. Read More

Asian J Pharm Sci 2022 Mar 31;17(2):177-192. Epub 2021 Oct 31.

Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.

Chemodynamic therapy (CDT) is considered as a promising modality for selective cancer therapy, which is realized via Fenton reaction-mediated decomposition of endogenous HO to produce toxic hydroxyl radical (•OH) for tumor ablation. While extensive efforts have been made to develop CDT-based therapeutics, their efficacy is usually unsatisfactory due to poor catalytic activity limited by tumor microenvironment, such as anti-oxidative systems, insufficient HO, and mild acidity. To mitigate these issues, we have witnessed a surge in the development of CDT-based combinatorial nanomedicines with complementary or synergistic mechanisms for enhanced tumor therapy. Read More

Asian J Pharm Sci 2022 Mar 16;17(2):219-229. Epub 2022 Jan 16.

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.

To utilize the multiple functions and give full play of ginsenosides, a variety of ginsenosides with different structures were prepared into liposomes and evaluated for their effect on the stability, pharmacokinetics and tumor targeting capability of liposomes. The results showed that the position and number of glycosyl groups of ginsenosides have significant effect on the and properties of their liposomes. The pharmacokinetics of ginsenosides liposomes indicated that the C-3 sugar group of ginsenosides is beneficial to their liposomes for longer circulation . Read More

Asian J Pharm Sci 2022 Mar 25;17(2):253-267. Epub 2022 Feb 25.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy (PDT). Hence, in this study, indocyanine green (ICG)-loaded lipid-coated zinc peroxide (ZnO) nanoparticles ([email protected]) was constructed to realize tumour microenvironment (TME)-responsive self-oxygen supply. Near infrared light irradiation (808 nm), the lipid outer layer of ICG acquires sufficient energy to produce heat, thereby elevating the localised temperature, which results in accelerated ZnO release and apoptosis of tumour cells. Read More

Asian J Pharm Sci 2022 Mar 21;17(2):284-297. Epub 2022 Mar 21.

Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai 200032, China.

Cardiovascular disease is the leading cause of global mortality, with anticoagulant therapy being the main prevention and treatment strategy. Recombinant hirudin (r-hirudin) is a direct thrombin inhibitor that can potentially prevent thrombosis via subcutaneous (SC) and intravenous (IV) administration, but there is a risk of haemorrhage via SC and IV. Thus, microneedle (MN) provides painless and sanitary alternatives to syringes and oral administration. Read More

Asian J Pharm Sci 2022 Mar 16;17(2):206-218. Epub 2022 Jan 16.

West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

The combination of Ce6, an acknowledged photosensitizer, and TPL, a natural anticancer agent, has been demonstrated as a useful strategy to reinforce the tumor growth suppression, as well as decrease the systemic side effects compared with their monotherapy. However, in view of the optimal chemo-photodynamic combination efficiency, there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL, and stimuli-responsively burst release drugs in tumor site. Herein, we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem, mediated by the host-guest complexing between β-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG, showing the shell-core structural micelles with the tight β-CD layer coating. Read More

Asian J Pharm Sci 2022 Mar 27;17(2):268-283. Epub 2022 Feb 27.

Department of Pharmacy, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Psoriasis is a common chronic immune-mediated skin disease characterized by hyperproliferation and aberrant differentiation of keratinocytes and massive infiltration of inflammatory immune cells. Recent studies showed that Signal Transducer and Activator of Transcription 3 (STAT3), which plays an important role in cell survival, proliferation, differentiation, angiogenesis, and immune responses, is constitutively activated in epidermal keratinocytes of human psoriatic skin lesions. In addition, STAT3 promotes the differentiation and expansion of T cells and facilitates cytokine production, thereby exacerbating the condition of psoriasis. Read More

J Ocean Univ China 2022 13;21(3):531-540. Epub 2022 May 13.

College of Marine Sciences, Beibu Gulf Ocean Development Research Center, Beibu Gulf University, Qinzhou, 535011 China.

Identification, protection and restoration of spawning habitats are vital for protecting the depleted species. Asian horseshoe crabs are ecologically important macroinvertebrates in coastal and estuarine ecosystems. However, their spawning habitat studies were limited to several reports in tropical regions, possibly due to the lack of modified survey methods, particularly in habitats with a lower density of spawning adults, and/or intermingled with anthropogenic structures. Read More

IEEE Trans Big Data 2021 Dec 21;7(6):952-960. Epub 2020 May 21.

Department of Computer ScienceUniversity of Rochester Rochester NY 14627 USA.

With the world-wide development of 2019 novel coronavirus, although WHO has officially announced the disease as COVID-19, one controversial term - "Chinese Virus" is still being used by a great number of people. In the meantime, global online media coverage about COVID-19-related racial attacks increases steadily, most of which are anti-Chinese or anti-Asian. As this pandemic becomes increasingly severe, more people start to talk about it on social media platforms such as Twitter. Read More

World J Gastroenterol 2022 Apr;28(15):1563-1573

Department of Medicine, Division of Gastroenterology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.

Background: Identifying hepatic fibrosis is crucial for nonalcoholic fatty liver disease (NAFLD) management. The fibrosis-8 (FIB-8) score, recently developed by incorporating four additional variables into the fibrosis-4 (FIB-4) score, showed better performance in predicting significant fibrosis in NAFLD.

Aim: To validate the FIB-8 score in a biopsy-proven NAFLD cohort and compare the diagnostic performance of the FIB-8 and FIB-4 scores and NAFLD fibrosis score (NFS) for predicting significant fibrosis. Read More

J Int Assoc Provid AIDS Care 2022 Jan-Dec;21:23259582221101811

Department of Pediatrics, Faculty of Medicine Siriraj Hospital, 26685Mahidol University, Bangkok, Thailand.

Integrative mental health care in HIV patients is an important contributor to successful therapy. This is a cross-sectional study in youth and young adults who attend routine HIV clinic at a tertiary care centre in Bangkok. We recruited 100 youth and 130 young adults living with HIV to evaluate the frequency of depression and anxiety and associated sociodemographic including sexual orientation and health-related behaviours. Read More

J Cardiothorac Surg 2022 May 17;17(1):120. Epub 2022 May 17.

Department of Cardiothoracic Surgery, The First People's Hospital of Neijiang, Shizhong District, No. 1866, West Section of Hanan Avenue, Neijiang, 641000, Sichuan, China.

Background: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer, which mostly occurred in non-smoking Asian populations. The prognosis of this tumor is better than other lung cancers. Polymyositis, a kind of idiopathic inflammatory myopathies, may negatively affect the prognosis of patients with lung cancer as a paraneoplastic syndrome (PNPS). Read More

BMC Pediatr 2022 May 17;22(1):288. Epub 2022 May 17.

Division of Nephrology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Bladder and bowel dysfunction (BBD) is a common disorder in children that is often associated with psychosocial and behavioral problems. Data specific to BBD in Asian children are comparatively scarce. Accordingly, this study aimed to investigate the prevalence of BBD and the response to standard urotherapy among Thai children attending the general pediatric outpatient clinic of Siriraj Hospital - Thailand's largest national tertiary referral center. Read More

Sci Rep 2022 May 17;12(1):8181. Epub 2022 May 17.

Information Engineering University, Zhengzhou, 450001, China.

Being the first mixed-constellation global navigation system, the global BeiDou navigation system (BDS-3) designs new signals, the service performance of which has attracted extensive attention. In the present study, the Signal-in-space range error (SISRE) computation method for different types of navigation satellites was presented. The differential code bias (DCB) correction method for BDS-3 new signals was deduced. Read More