2,406 results match your criteria Asian Journal of Andrology[Journal]


Success rates of fertilization versus intracytoplasmic sperm injection in men with serum anti-sperm antibodies: a consecutive cohort study.

Asian J Androl 2019 Jan 29. Epub 2019 Jan 29.

Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan 250000, China.

Antisperm antibodies (ASAs) are assumed to be a possible causative factor for male infertility, with ASAs detected in 5%-15% of infertile men but in only 1%-2% of fertile ones. It remains unclear whether ASAs have an adverse effect on the outcome of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). This study investigated differences in the rates of fertilization, pregnancy, and live births associated with serum ASA-positive and ASA-negative men following IVF or ICSI. Read More

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http://dx.doi.org/10.4103/aja.aja_124_18DOI Listing
January 2019
1 Read

PLZFc-KIT-delineated A-A-differentiating spermatogonia by subset and stage detection upon Bouin fixation.

Asian J Androl 2019 Jan 29. Epub 2019 Jan 29.

Institute of Reproduction and Stem Cell Engineering, School of Basic Medicine Science, Central South University, Changsha 410078, China.

While hallmarks of rodent spermatogonia stem cell biomarkers' heterogeneity have recently been identified, their stage and subset distributions remain unclear. Furthermore, it is currently difficult to accurately identify subset-specific SSC marker distributions due to the poor nuclear morphological characteristics associated with fixation in 4% paraformaldehyde. In the present study, testicular cross-sections and whole-mount samples were Bouin fixed to optimize nuclear resolution and visualized by immunohistochemistry (IHC) and immunofluorescence (IF). Read More

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http://dx.doi.org/10.4103/aja.aja_103_18DOI Listing
January 2019

Ambient ozone pollution is associated with decreased semen quality: longitudinal analysis of 8945 semen samples from 2015 to 2018 and during pollution-control period in Beijing, China.

Asian J Androl 2019 Jan 22. Epub 2019 Jan 22.

Department of Urology, Peking University Third Hospital, Beijing 100191, China.

Previous studies suggest that air pollution has a negative effect on semen quality. However, most studies are cross-sectional and the results are controversial. This study investigated the associations between air pollutants (PM, PM, SO, NO, CO, and O) and semen quality among sperm donation candidates, especially when the air pollution was artificially controlled in Beijing, China. Read More

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http://dx.doi.org/10.4103/aja.aja_116_18DOI Listing
January 2019

The role of tumor size, ultrasonographic findings, and serum tumor markers in predicting the likelihood of malignant testicular histology.

Asian J Androl 2019 Jan 15. Epub 2019 Jan 15.

Department of Urology, Peking University First Hospital, Beijing 100034, China.

The clinical predictive factors for malignant testicular histology remain unclear because of the low prevalence. Therefore, the aim of this study was to investigate predictors of malignant histology for testicular masses and decide more testis-sparing surgeries before surgery. This retrospective study enrolled 325 consecutive testicular mass patients who underwent radical orchiectomy (310/325) or testicular preserving surgery (15/325) from January 2001 to June 2016. Read More

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http://www.ajandrology.com/preprintarticle.asp?id=250280
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http://dx.doi.org/10.4103/aja.aja_119_18DOI Listing
January 2019
4 Reads

Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men.

Asian J Androl 2019 Jan 15. Epub 2019 Jan 15.

S. H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

It is largely unknown whether lower urinary tract symptoms (LUTS) or acute retention of urine (AROU) is linked to shorter life expectancy in men. We conducted a multicenter, retrospective database analysis of patients undergoing transurethral resection of prostate (TURP) to study their relationships. Multivariate Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were performed. Read More

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http://dx.doi.org/10.4103/aja.aja_101_18DOI Listing
January 2019
4 Reads

and play vital roles in occurrence of congenital bilateral absence of vas deferens (CBAVD).

Asian J Androl 2019 Jan 11. Epub 2019 Jan 11.

Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

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http://www.ajandrology.com/preprintarticle.asp?id=250033
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http://dx.doi.org/10.4103/aja.aja_112_18DOI Listing
January 2019
13 Reads

Critical evaluation of two models of flow cytometers for the assessment of sperm DNA fragmentation: an appeal for performance verification.

Asian J Androl 2019 Jan 8. Epub 2019 Jan 8.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

Lack of standardized, reproducible protocols and reference values is among the challenges faced when using new or upgraded versions of instruments in reproductive laboratories and flow cytometry. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay combined with flow cytometry routinely used for diagnostic measurement of sperm DNA fragmentation (SDF) is a unique example. Any change in the setting of the standard instrument, including upgrades of hardware or software, can lead to different results and may affect clinicians' decision for treatment. Read More

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http://www.ajandrology.com/preprintarticle.asp?id=249652
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http://dx.doi.org/10.4103/aja.aja_109_18DOI Listing
January 2019
3 Reads
2.530 Impact Factor

Protein kinase A inhibition induces EPAC-dependent acrosomal exocytosis in human sperm.

Asian J Androl 2018 Dec 18. Epub 2018 Dec 18.

The Mina and Everard Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel.

To interact with the egg, the spermatozoon must undergo several biochemical and motility modifications in the female reproductive tract, collectively called capacitation. Only capacitated sperm can undergo acrosomal exocytosis, near or on the egg, a process that allows the sperm to penetrate and fertilize the egg. In the present study, we investigated the involvement of cyclic adenosine monophosphate (cAMP)-dependent processes on acrosomal exocytosis. Read More

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http://dx.doi.org/10.4103/aja.aja_99_18DOI Listing
December 2018
4 Reads

Clinical and socioeconomic factors associated with delayed orchidopexy in cryptorchid boys in China: a retrospective study of 2423 cases.

Asian J Androl 2018 Dec 18. Epub 2018 Dec 18.

Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

We investigated the associations of clinical and socioeconomic factors with delayed orchidopexy for cryptorchidism in China. A retrospective study was conducted on cryptorchid boys who underwent orchidopexy at Children's Hospital at Chongqing Medical University in China from January 2012 to December 2017. Of 2423 patients, 410 (16. Read More

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http://dx.doi.org/10.4103/aja.aja_106_18DOI Listing
December 2018
3 Reads
2.530 Impact Factor

Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.

Asian J Androl 2019 Jan 1. Epub 2019 Jan 1.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

The aim of this study was to investigate the mechanism by which a diet inducing high hyperhomocysteinemia (HHcy) leads to the deterioration of erectile function in rats and whether this is inhibited by expression of the human tissue kallikrein-1 (hKLK1) gene. We established a rat model of HHcy by feeding methionine (Met)-rich diets to male Sprague-Dawley (SD) rats. Male wild-type SD rats (WTRs) and transgenic rats harboring the hKLK1 gene (TGRs) were fed a normal diet until 10 weeks of age. Read More

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http://dx.doi.org/10.4103/aja.aja_111_18DOI Listing
January 2019
5 Reads

The effect of vitamin D on sperm motility and the underlying mechanism.

Asian J Androl 2019 Jan 1. Epub 2019 Jan 1.

Center of Reproductive Medicine, Nanjing Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.

Vitamin D deficiency is a common health issue around the world. We therefore evaluated the associations of semen quality with both serum and seminal plasma vitamin D levels and studied the mechanisms underlying these by incubating spermatozoa with 1,25(OH)D In vitro. Two hundred and twenty-two men were included in our study. Read More

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http://dx.doi.org/10.4103/aja.aja_105_18DOI Listing
January 2019
5 Reads

Sequential testis sparing surgery of simultaneous bilateral testicular tumors with different cell types in a Chinese infant: an uncommon presentation.

Asian J Androl 2019 Jan 1. Epub 2019 Jan 1.

Department of Urology, Children's Hospital of Shanghai, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China.

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http://dx.doi.org/10.4103/aja.aja_104_18DOI Listing
January 2019
1 Read

Toll-like receptor 10 (TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells.

Asian J Androl 2019 Jan 1. Epub 2019 Jan 1.

Department of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu 610041, China.

Prostate inflammation (PI) is closely related to the development and progression of chronic prostatic diseases: benign prostatic hyperplasia and prostate cancer. Toll-like receptor (TLR) 2 has been reported to be associated with inflammatory diseases, such as infections, autoimmune diseases, and cancers. Meanwhile, TLR10, which can form heterodimers with TLR2, has been considered an orphan receptor without an exact function. Read More

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http://dx.doi.org/10.4103/aja.aja_100_18DOI Listing
January 2019
1 Read
2.530 Impact Factor

MicroRNA expression profile in chronic nonbacterial prostatitis revealed by next-generation small RNA sequencing.

Asian J Androl 2018 Dec 25. Epub 2018 Dec 25.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

MicroRNAs (miRNAs) are considered to be involved in the pathogenic initiation and progression of chronic nonbacterial prostatitis (CNP); however, the comprehensive expression profile of dysregulated miRNAs, relevant signaling pathways, and core machineries in CNP have not been fully elucidated. In the current research, CNP rat models were established through the intraprostatic injection of carrageenan into the prostate. Then, next-generation sequencing was performed to explore the miRNA expression profile in CNP. Read More

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http://dx.doi.org/10.4103/aja.aja_97_18DOI Listing
December 2018
4 Reads

The current status of hormone treatment for prostate cancer patients in Korean real-world practice: a multi-institutional observational study.

Asian J Androl 2018 Dec 25. Epub 2018 Dec 25.

Department of Urology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.

We aimed to evaluate the current nationwide trend, efficacy, safety, and quality of life (QoL) profiles of hormone treatment in real-world practice settings for prostate cancer (PCa) patients in Korea. A total of 292 men with any biopsy-proven PCa (TanyNanyMany) from 12 institutions in Korea were included in this multi-institutional, observational study of prospectively collected data. All luteinizing hormone-releasing hormone (LHRH) agonists were allowed to be investigational drugs. Read More

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http://dx.doi.org/10.4103/aja.aja_95_18DOI Listing
December 2018
1 Read

Testosterone undecanoate supplementation together with human chorionic gonadotropin does not impair spermatogenesis in males with isolated hypogonadotropic hypogonadism: a retrospective study.

Asian J Androl 2018 Dec 25. Epub 2018 Dec 25.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Gonadotropin therapy is commonly used to induce virilization and spermatogenesis in male isolated hypogonadotropic hypogonadism (IHH) patients. In clinical practice, 5.6%-15. Read More

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http://dx.doi.org/10.4103/aja.aja_107_18DOI Listing
December 2018
3 Reads

Effects of percutaneous varicocele repair on testicular volume: results from a 12-month follow-up.

Asian J Androl 2018 Dec 25. Epub 2018 Dec 25.

Department of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy.

Varicocele is a common finding in men. Varicocele correction has been advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular "catch-up growth" in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. Read More

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http://dx.doi.org/10.4103/aja.aja_102_18DOI Listing
December 2018
2 Reads
2.530 Impact Factor

Clinical activity of abiraterone plus prednisone in docetaxel-naοve and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer.

Asian J Androl 2018 Nov 16. Epub 2018 Nov 16.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 20032, China.

This study investigated the clinical activity of abiraterone plus prednisone in docetaxel-naïve and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer (mCRPC). A total of 146 patients with docetaxel-naïve group (103 cases) and docetaxel-resistant group (43 cases) were enrolled from the Shanghai Cancer Center (Shanghai, China) in this retrospective cohort study. The efficacy endpoints were prostate-specific antigen response rate, prostate-specific antigen progression-free survival, clinical/radiographic progression-free survival, and overall survival in response to abiraterone plus prednisone. Read More

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http://dx.doi.org/10.4103/aja.aja_85_18DOI Listing
November 2018
2 Reads

Leptin and its actions on reproduction in males.

Asian J Androl 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sg Buloh 47000, Selangor, Malaysia.

Leptin, an adipocyte-derived hormone, serves numerous physiological functions in the body, particularly during puberty and reproduction. The exact mechanism by which leptin activates the gonadotropin-releasing hormone (GnRH) neurons to trigger puberty and reproduction remains unclear. Given the widespread distribution of leptin receptors in the body, both central and peripheral mechanisms involving the hypothalamic-pituitary-gonadal axis have been hypothesized. Read More

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http://dx.doi.org/10.4103/aja.aja_98_18DOI Listing
December 2018
16 Reads
2.530 Impact Factor

Inhibin B: are modified ranges needed for orchiectomised testicular cancer patients?

Asian J Androl 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Seminology, Sperm Bank "Loredana Gandini", Department of Experimental Medicine, Medical Pathophysiology Section, "Sapienza" University of Rome, Rome 00161, Italy.

Inhibin B is a gonadal hormone that downregulates the pituitary production of follicle-stimulating hormone (FSH). In recent years, inhibin B has proved to be an excellent marker of spermatogenesis and even a predictive factor for the recovery of fertility in patients undergoing orchiectomy and antineoplastic treatments. We propose to study inhibin B levels in orchiectomised testicular cancer patients, in order to identify a minimum value representative of normal semen quality. Read More

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http://dx.doi.org/10.4103/aja.aja_93_18DOI Listing
December 2018
3 Reads

The 14 international prostate forum.

Asian J Androl 2018 Dec 7. Epub 2018 Dec 7.

Koç University, School of Medicine, Department of Urology, Istanbul 34365, Turkey.

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http://www.ajandrology.com/text.asp?2019/21/1/1/247093
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http://dx.doi.org/10.4103/aja.aja_108_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337951PMC
December 2018
2 Reads

Predictive significance of serum inhibin B on testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men.

Asian J Androl 2018 Nov 30. Epub 2018 Nov 30.

Center for Reproductive Medicine, Shandong University, Jinan 250001, China.

The purpose of this study was to determine the diagnostic accuracy of serum inhibin B (INHB) as a predictor of the retrieval outcome of testicular haploid gametes (spermatids and testicular spermatozoa) in nonobstructive azoospermic men. Serum hormone levels, testicular volume, and histological evaluation were performed in 403 Chinese nonobstructive azoospermic men. Testicular haploid gamete was successfully retrieved in 213 of 403 patients (52. Read More

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http://dx.doi.org/10.4103/aja.aja_94_18DOI Listing
November 2018
2 Reads

Simplifying the ShangRing technique for circumcision in boys and men: use of the no-flip technique with randomization to removal at 7 days versus spontaneous detachment.

Asian J Androl 2018 Nov 30. Epub 2018 Nov 30.

EngenderHealth, Nairobi 00100, Kenya.

To assess safety of the no-flip ShangRing male circumcision technique and to determine clinical course and safety of spontaneous detachment (i.e., allowing the device to fall off), we conducted a case series of no-flip ShangRing circumcision combined with a randomized controlled trial of removal 7 days postcircumcision versus spontaneous detachment at two health facilities in Kenya. Read More

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http://dx.doi.org/10.4103/aja.aja_91_18DOI Listing
November 2018
2 Reads

Outcomes of men aged ≤50 years treated with radical prostatectomy: a retrospective analysis.

Asian J Androl 2018 Nov 20. Epub 2018 Nov 20.

Department of Urology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.

Previous studies investigating prostate cancer (PCa) features in younger men have reported conflicting findings. This study aimed to investigate pathologic outcomes and biochemical recurrence (BCR) status in younger men who underwent radical prostatectomy (RP) for PCa. Records of 2057 patients who underwent RP at Seoul National University Bundang Hospital (Seongnam, Korea) between 2006 and 2015 were reviewed; patients were divided according to age into the younger and older groups (men aged ≤50 and >50 years, respectively). Read More

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http://dx.doi.org/10.4103/aja.aja_92_18DOI Listing
November 2018
8 Reads

A novel rat model of seminal vesiculitis.

Asian J Androl 2018 Nov 20. Epub 2018 Nov 20.

Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China.

We aimed to establish a novel rat model of seminal vesiculitis that would provide an effective approach to investigate the pathogenesis of this disease in the future. Eight male rats received the same operation, during which the root of one of the two seminal vesicles was partly ligatured with sutures and the other vesicle was left intact. The samples of seminal vesicles were harvested on the 8 day following the operation. Read More

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http://dx.doi.org/10.4103/aja.aja_90_18DOI Listing
November 2018
13 Reads

Enzalutamide: a new indication for nonmetastatic castration-resistant prostate cancer.

Asian J Androl 2018 Nov 20. Epub 2018 Nov 20.

GU Medical Oncology, Inova Schar Cancer Institute, Fairfax, VA 22031, USA.

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http://dx.doi.org/10.4103/aja.aja_88_18DOI Listing
November 2018
1 Read

Psychological burden prediction based on demographic variables among infertile men with sexual dysfunction.

Asian J Androl 2018 Nov 20. Epub 2018 Nov 20.

Department of Andrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

There has been increasing interest in the psycho-socio-relational and sexual disorders of infertility, as the risk of psychological burden among infertile men with sexual dysfunctions is significant. The purpose of this study was to develop and to validate a predictive model to estimate individual psychological burden among infertile men with sexual dysfunction and study the association between them. Comprehensive data were collected for infertile men (n = 480) who sought treatment for infertility in a reproductive medicine center between June 2012 and December 2013. Read More

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http://dx.doi.org/10.4103/aja.aja_86_18DOI Listing
November 2018
10 Reads

Separate Chinese lines for prostate cancer?

Asian J Androl 2018 Nov 20. Epub 2018 Nov 20.

Center for Tobacco Control Research, Birkevej 17, DK-5230 Odense M, Denmark.

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http://dx.doi.org/0.4103/aja.aja_71_18DOI Listing
November 2018
2 Reads

Validation of targeted microsurgical spermatic cord denervation: comparison of outcomes to traditional complete microsurgical spermatic cord denervation.

Asian J Androl 2018 Nov 9. Epub 2018 Nov 9.

Austin Fertility and Reproductive Medicine, Austin, TX 78746, USA.

The aim of this study was to validate the effectiveness of targeted microsurgical spermatic cord denervation (MSCD) of the trifecta nerve complex in comparison to traditional full MSCD with complete skeletonization of the spermatic cord in men with chronic orchialgia. Retrospective chart review was performed by a single fellowship-trained microsurgeon between 2011 and 2016. Patients had follow-ups at 6 weeks, 6 months, and 1 year postoperatively. Read More

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http://dx.doi.org/10.4103/aja.aja_87_18DOI Listing
November 2018
8 Reads

The preoperative serum cystatin-C as an independent prognostic factor for survival in upper tract urothelial carcinoma.

Asian J Androl 2018 Nov 9. Epub 2018 Nov 9.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.

Cystatin-C (Cys-C) has been reported as a valuable prognostic biomarker in various malignancies. However, its effect on upper tract urothelial carcinoma (UTUC) patients has not been investigated before. Thus, to explore the impact of Cys-C on survival outcomes in patients undergoing radical nephroureterectomy (RNU), a total of 538 patients with UTUC who underwent RNU between 2005 and 2014 in our center (West China Hospital, Chengdu, China) were included in this study. Read More

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http://dx.doi.org/10.4103/aja.aja_84_18DOI Listing
November 2018
12 Reads

The therapeutic effect of pelvic floor muscle exercise on urinary incontinence after radical prostatectomy: a meta-analysis.

Asian J Androl 2018 Nov 2. Epub 2018 Nov 2.

Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Pelvic floor muscle exercise (PFME) is the most common conservative management for urinary incontinence (UI) after radical prostatectomy (RP). However, whether the PFME guided by a therapist (G-PFME) can contribute to the recovery of urinary continence for patients after RP is still controversial. We performed this meta-analysis to investigate the effectiveness of G-PFME on UI after RP and to explore whether the additional preoperative G-PFME is superior to postoperative G-PFME alone. Read More

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http://dx.doi.org/10.4103/aja.aja_89_18DOI Listing
November 2018
7 Reads

Novel noninvasive quantification of penile corpus cavernosum lesions in hyperlipidemia-induced erectile dysfunction in rabbits by two-dimensional shear-wave elastography.

Asian J Androl 2018 Nov 2. Epub 2018 Nov 2.

Department of Medical Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China.

Structural alterations in fibroelastic components of the penile corpus cavernousum (CC) may impair its compliance, resulting in venous leakage and erectile dysfunction (ED). Our study evaluated the effectiveness of noninvasive two-dimensional shear-wave elastography (2-D SWE) in quantifying penile CC lesions in rabbits with hyperlipidemia-induced ED. A total of 12 New Zealand white rabbits were randomly divided into two groups. Read More

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http://dx.doi.org/10.4103/aja.aja_78_18DOI Listing
November 2018
4 Reads

Regulation of anti-Müllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility.

Asian J Androl 2018 Oct 26. Epub 2018 Oct 26.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

Anti-Müllerian hormone (AMH) is a functional marker of fetal Sertoli cells. The germ cell number in adults depends on the number of Sertoli cells produced during perinatal development. Recently, AMH has received increasing attention in research of disorders related to male fertility. Read More

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http://dx.doi.org/10.4103/aja.aja_83_18DOI Listing
October 2018
9 Reads

The applied research of simultaneous image acquisition of T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) in the assessment of patients with prostate cancer.

Asian J Androl 2018 Oct 26. Epub 2018 Oct 26.

Department of Radiology, Peking University First Hospital, Beijing 100034, China.

We aimed to evaluate the feasibility of simultaneous image acquisition of multiple instantaneous switchable scan (MISS) for prostate magnetic resonance imaging (MRI) on 3T. Fifty-three patients were scanned with MRI due to suspected prostate cancer. Twenty-eight of them got histological results. Read More

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http://dx.doi.org/10.4103/aja.aja_82_18DOI Listing
October 2018
1 Read
2.530 Impact Factor

Hypogonadism is independently associated with varicocele repair in a contemporary cohort of men in the USA.

Asian J Androl 2018 Oct 26. Epub 2018 Oct 26.

Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA.

We aimed to identify demographic and clinical predictors of varicocele repair in a contemporary cohort of men in the USA. We queried the 2009-2015 MarketScan Database using relevant ICD9, ICD10, and CPT codes to identify all 18-45 year olds with varicoceles. Differences in age, area of residence, clinical characteristics, and medical management between men who did and did not undergo varicocelectomy (open, laparoscopic, or microsurgical) during the study period were compared using unpaired t-tests and Chi-squared tests for continuous and categorical variables, respectively. Read More

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http://dx.doi.org/10.4103/aja.aja_61_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337954PMC
October 2018
2 Reads

Proteomic analysis reveals dysregulated cell signaling in ejaculated spermatozoa from infertile men.

Asian J Androl 2018 Oct 26. Epub 2018 Oct 26.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

Dysfunctional sperm maturation is the primary reason for the poor sperm motility and morphology in infertile men. Spermatozoa from infertile men were fractioned on three-layer density gradient (80%, 60%, and 40%). Fraction 1 (F1) refers to the least mature stage having the lowest density, whereas the fraction 4 (F4) includes the most dense and morphologically mature motile spermatozoa. Read More

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http://dx.doi.org/10.4103/aja.aja_56_18DOI Listing
October 2018
8 Reads
2.530 Impact Factor

Novel variants in globozoospermic patients and the overcoming this male infertility.

Asian J Androl 2018 Oct 16. Epub 2018 Oct 16.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Globozoospermia has been reported to be a rare but severe causation of male infertility, which results from the failure of acrosome biogenesis and sperm head shaping. Variants of dpy-19-like 2 (DPY19L2) are highly related to globozoospermia, but related investigations have been mainly performed in patients from Western countries. Here, we performed a screening of DPY19L2 variants in a cohort of Chinese globozoospermic patients and found that five of nine patients carried DPY19L2 deletions and the other four patients contained novel DPY19L2 point mutations, as revealed by whole-exome sequencing. Read More

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http://dx.doi.org/10.4103/aja.aja_79_18DOI Listing
October 2018
3 Reads
2.530 Impact Factor

Direct modification of spermatogonial stem cells using lentivirus vectors leads to efficient generation of transgenic rats.

Asian J Androl 2018 Oct 12. Epub 2018 Oct 12.

Department of Animal Science and Technology, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong, Gyeonggi-do 17546, Korea.

Spermatogonial stem cells (SSCs) transmit genetic information to the next progeny in males. Thus, SSCs are a potential target for germline modifications to generate transgenic animals. In this study, we report a technique for the generation of transgenic rats by in vivo manipulation of SSCs with a high success rate. Read More

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http://dx.doi.org/10.4103/aja.aja_80_18DOI Listing
October 2018
2 Reads

Sodium nitrite-derived nitric oxide protects rat testes against ischemia/reperfusion injury.

Asian J Androl 2018 Oct 12. Epub 2018 Oct 12.

The Institute for the 3Rs & Department of Laboratory Animal Medicine, College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul 05029, Korea.

Testicular torsion, a common urologic emergency, is primarily caused by ischemia/reperfusion (I/R) injury of the testis. Nitric oxide (NO)-derived from nitrite (NO) has been reported to have prominent therapeutic effects on I/R injury in the heart, liver, and brain; however, its effects on testicular I/R injury have not been evaluated. This study, therefore, investigated whether NO from NO is beneficial in a rat model of testicular I/R injury which eventually results in impaired spermatogenesis. Read More

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http://dx.doi.org/10.4103/aja.aja_76_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337950PMC
October 2018
8 Reads

The survival and prognostic factors of primary testicular lymphoma: two-decade single-center experience.

Asian J Androl 2018 Nov-Dec;20(6):615-620

Department of Urology, Peking University Third Hospital, Beijing 100191, China.

This study aims to investigate the effect of different local testicular treatments and validate common prognostic factors on primary testicular lymphoma (PTL) patients. We retrospectively reviewed the clinical records of 32 patients from 1993 to 2017 diagnosed with PTL and included 22 patients for analysis. The Kaplan-Meier method, Log-rank test, and multivariate Cox proportional hazard regression analysis were applied to evaluate progression-free survival (PFS), overall survival (OS), and determine prognosis predictors. Read More

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http://dx.doi.org/10.4103/aja.aja_73_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219299PMC
September 2018
15 Reads

G protein-coupled receptor kinase 2 inhibition improves erectile function through amelioration of endothelial dysfunction and oxidative stress in a rat model of type 2 diabetes.

Asian J Androl 2018 09 14. Epub 2018 Sep 14.

Department of Urology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.

Type 2 diabetes mellitus (T2DM) is a common cause of erectile dysfunction (ED). It has been demonstrated that G protein-coupled receptor kinase 2 (GRK2) overexpression contributes to diabetic endothelial dysfunction and oxidative stress, which also underlies ED in T2DM. We hypothesized that GRK2 overexpressed and attenuated endothelial function of the cavernosal tissue in a rat model of T2DM. Read More

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http://dx.doi.org/10.4103/aja.aja_69_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337949PMC
September 2018
3 Reads

Mean platelet volume might be an effective indicator of arterial erectile dysfunction.

Asian J Androl 2018 Sep 7. Epub 2018 Sep 7.

Department of Urology, the Second Hospital of Shandong University, Jinan 250033, China.

The aim of our study was to investigate the role of platelet parameters including mean platelet volume (MPV) and platelet count (PC) in the pathogenesis of penile arteriogenic erectile dysfunction (ED) and to evaluate the association between the platelet parameters and arteriogenic ED. There were 244 patients with ED (based on the International Index of Erectile Function [IIEF]-5 ≤21) and 60 healthy controls (IIEF-5 >21) enrolled. All participants were asked to undergo a laboratory examination, and penile vascular function was evaluated using penile color Doppler ultrasonography (pDUS). Read More

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http://dx.doi.org/10.4103/aja.aja_74_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337960PMC
September 2018
13 Reads

Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression.

Asian J Androl 2018 Sep 7. Epub 2018 Sep 7.

Department of Surgery II, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

Lycopene is a natural compound that alleviates oxidative stress and inflammation, exerting therapeutic effects in a number of cancers. The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer. Cell viability assays indicated the dose- and time-dependent toxicity of lycopene in prostate cancer cells. Read More

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http://dx.doi.org/10.4103/aja.aja_70_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337959PMC
September 2018
3 Reads

Resveratrol attenuates metabolic, sperm, and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates.

Asian J Androl 2018 Sep 7. Epub 2018 Sep 7.

Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro 20551-030, Brazil.

High-fat diets affect male reproduction and sexual function. Therefore, we evaluated the effects of prolonged resveratrol administration on the metabolic, sperm, and testicular parameters of rats fed a cafeteria diet. Male Wistar rats were divided at weaning into control (C, n = 20) and cafeteria (CAF, n = 16) groups. Read More

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http://dx.doi.org/10.4103/aja.aja_67_18DOI Listing
September 2018
1 Read

Strawberry Notch 1 (SBNO1) promotes proliferation of spermatogonial stem cells via the noncanonical Wnt pathway in mice.

Asian J Androl 2018 Sep 7. Epub 2018 Sep 7.

Department of Histology and Embryology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China.

While it is known that spermatogonial stem cells (SSCs) initiate the production of male germ cells, the mechanisms of SSC self-renewal, proliferation, and differentiation remain poorly understood. We have previously identified Strawberry Notch 1 (SBNO1), a vertebrate strawberry notch family protein, in the proteome profile for mouse SSC maturation and differentiation, revealing SBNO1 is associated with neonatal testicular development. To explore further the location and function of SBNO1 in the testes, we performed Sbno1 gene knockdown in mice to study the effects of SBNO1 on neonatal testicular and SSC development. Read More

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http://dx.doi.org/10.4103/aja.aja_65_18DOI Listing
September 2018
5 Reads

Time trend and characteristics of prostate cancer diagnosed in Hong Kong (China) in the past two decades.

Asian J Androl 2018 Sep 4. Epub 2018 Sep 4.

S. H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.4103/aja.aja_75_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337957PMC
September 2018
1 Read

The regulatory pathways leading to stem-like cells underlie prostate cancer progression.

Asian J Androl 2018 Sep 4. Epub 2018 Sep 4.

Department of Urology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surgery and radiation. For patients with distant metastases, androgen deprivation therapy (ADT) is a gold standard. Read More

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http://dx.doi.org/10.4103/aja.aja_72_18DOI Listing
September 2018
1 Read

Does prostate-specific antigen (PSA) mass or free PSA mass improve the accuracy of predicting total prostate volume in relation to obesity in men with biopsy-proven benign prostatic hyperplasia?

Asian J Androl 2018 Sep 4. Epub 2018 Sep 4.

Department of Urology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.

We evaluated whether the prostate-specific antigen (PSA) mass or free PSA (fPSA) mass (i.e., absolute amount of total circulating PSA or fPSA protein, respectively), versus serum PSA or fPSA concentration, improves the accuracy of predicting the total prostate volume (TPV) in relation to obesity. Read More

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http://dx.doi.org/10.4103/aja.aja_66_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337953PMC
September 2018
7 Reads