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    2291 results match your criteria Asian Journal of Andrology[Journal]

    1 OF 46

    Erectile dysfunction is associated with subclinical carotid vascular disease in young men lacking widely-known risk factors.
    Asian J Androl 2018 Feb 9. Epub 2018 Feb 9.
    Division of Cardiovascular Rehabilitation, Heart Center, Key Laboratory on Assisted Circulation, Ministry of Health, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
    This study aimed to gain insight into the underlying pathogenesis of erectile dysfunction in young men under the age of 40 years without widely-known risk factors. Compared with normal controls, patients with erectile dysfunction had increased carotid intima-media thickness, fasting levels of blood glucose and insulin, and homeostatic model assessment index, as well as lower flow-mediated vasodilation and testosterone levels (P < 0.05), though all of these values were within their respective normal range. Read More

    Randomized controlled trials - mechanistic studies of testosterone and the cardiovascular system.
    Asian J Androl 2018 Feb 9. Epub 2018 Feb 9.
    Academic Unit of Diabetes, Endocrinology and Metabolism, Department of Oncology and Metabolism, University of Sheffield Medical School, Sheffield, UK.
    Testosterone deficiency is common in men with cardiovascular disease (CVD), and randomized placebo-controlled trials (RCTs) have reported beneficial effects of testosterone therapy on exercise-induced cardiac ischemia in chronic stable angina, functional exercise capacity, maximum oxygen consumption during exercise (VO) and muscle strength in chronic heart failure (CHF), shortening of the Q-T interval, and improvement of some cardiovascular risk factors. Testosterone deficiency is associated with an adverse CV risk profile and mortality. Clinical and scientific studies have provided mechanistic evidence to support and explain the findings of the RCTs. Read More

    Evaluation of PSA-age volume score in predicting prostate cancer in Chinese populationArticle Subject.
    Asian J Androl 2018 Feb 6. Epub 2018 Feb 6.
    Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
    This study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population. A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current study. The PSA-AV scores were calculated and assessed together with PSA and PSA density (PSAD) retrospectively. Read More

    Production of germline chimeric quails following spermatogonial cell transplantation in busulfan-treated testis.
    Asian J Androl 2018 Feb 6. Epub 2018 Feb 6.
    Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.

    Penile sensory thresholds in subtypes of premature ejaculation: implications of comorbid erectile dysfunction.
    Asian J Androl 2018 Feb 6. Epub 2018 Feb 6.
    Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.
    Penile hypersensitivity plays an important role in premature ejaculation (PE), but differences in penile sensitivity among subtypes of PE are unknown. Therefore, we compared penile sensory thresholds in PE subtypes of lifelong and acquired PE, PE with and without erectile dysfunction (ED), PE with an intravaginal ejaculation latency time ≤1 min and >1 min, and PE with and without orgasmic pleasure perceptual dysfunction. During August 2014 to January 2016, 136 patients with PE were included. Read More

    Current status of sperm banking for young cancer patients in Japanese nationwide survey.
    Asian J Androl 2018 Feb 2. Epub 2018 Feb 2.
    Division Male Infertility, Center for Human Reproduction, International University of Health and Welfare, Sanno Hospital, Tokyo 107-0052, Japan.
    This study aimed to ascertain the current status of Japanese sperm banking for young cancer patients. During 2015, we mailed the directors of 695 institutes where sperm cryopreservation might be performed with questionnaires requesting information on the number of patients, age, precryopreservation chemotherapy, semen analyses results and diagnoses, cryopreservation success rate, and causes of unsuccessful cryopreservation. Of these 695 institutes, 92 had cryopreserved sperm before chemotherapy within the study period. Read More

    The expression of the new epididymal luminal protein of PDZ domain containing 1 is decreased in asthenozoospermia.
    Asian J Androl 2018 Jan 19. Epub 2018 Jan 19.
    International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory for Reproductive Medicine, Institute of Embryo-Fetal Original Adult Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
    Spermatozoa are not mature until they transit the epididymis where they acquire motility and the ability to fertilize an egg through sequential modifications. The epididymis has three functional regions, caput, corpus, and cauda, and the luminal proteins of the epididymis play important roles in the above modifications. However, the proteins with differential enrichment between the caput and cauda are still largely unknown. Read More

    Endogenous testosterone and mortality risk.
    Asian J Androl 2018 Jan 30. Epub 2018 Jan 30.
    Endocrine, Diabetes and Metabolic Unit, Royal Adelaide Hospital, Port Road, SA 5000, Australia.
    In men, obesity and metabolic complications are associated with lower serum testosterone (T) and dihydrotestosterone (DHT) and an increased risk of, and mortality from, multiple chronic diseases in addition to cardiovascular disease (CVD). The causal interrelationships between these factors remain a matter of debate. In men with untreated congenital and lifelong forms of hypogonadotropic hypogonadism, there appears to be no increased risk. Read More

    Would male hormonal contraceptives affect cardiovascular risk?
    Asian J Androl 2018 Jan 30. Epub 2018 Jan 30.
    Center for Andrology and Reproductive Medicine, University Clinics Muenster, Muenster, Germany.
    The aim of hormonal male contraception is to prevent unintended pregnancies by suppressing spermatogenesis. Hormonal male contraception is based on the principle that exogenous administration of androgens and other hormones such as progestins suppress circulating gonadotropin concentrations, decreasing testicular Leydig cell and Sertoli cell activity and spermatogenesis. In order to achieve more complete suppression of circulating gonadotropins and spermatogenesis, a progestin has been added testosterone to the most recent efficacy trials of hormonal male contraceptives. Read More

    Immediate and late effects of chronic stress in the testes of prepubertal and adult rats.
    Asian J Androl 2018 Jan 30. Epub 2018 Jan 30.
    Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ 20551-030, Brazil.
    The objective of this study was to investigate the effects of chronic stress on the testes of prepubertal and adult rats and to evaluate whether any alterations could be reversed when stress induction is ended. Seventy-six male rats were assigned to eight groups depending on the type of treatment (control or stressed), the age at which stress was initiated (prepubertal or adult), and the time of evaluation (immediate or late). Stress stimuli were applied for 6 weeks. Read More

    Calpain inhibition improves erectile function in diabetic mice via upregulating endothelial nitric oxide synthase expression and reducing apoptosis.
    Asian J Androl 2018 Jan 9. Epub 2018 Jan 9.
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
    Calpain activation contributes to hyperglycemia-induced endothelial dysfunction and apoptosis. This study was designed to investigate the role of calpain inhibition in improving diabetic erectile dysfunction (ED) in mice. Thirty-eight-week-old male C57BL/6J mice were divided into three groups: (1) nondiabetic control group, (2) diabetic mice + vehicle group, and (3) diabetic mice + MDL28170 (an inhibitor of calpain) group. Read More

    Histological subtype is a significant predictor for inguinal lymph node metastasis in patients with penile squamous cell carcinoma.
    Asian J Androl 2017 Dec 29. Epub 2017 Dec 29.
    Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
    The present study aimed to investigate the relationship between histopathological subtype and the probability of inguinal lymph node metastasis (ILNM) in patients with penile squamous cell carcinoma (PSCC). The clinical records of 198 consecutive patients with PSCC were analyzed retrospectively. Primary lesions were reevaluated according to the 2016 World Health Organization (WHO) histopathological classification. Read More

    AlteredandmRNA expression in ejaculated spermatozoa of men with impaired sperm characteristics.
    Asian J Androl 2017 Dec 26. Epub 2017 Dec 26.
    Center for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Halle (Saale) 06120, Germany.
    In about half the cases of involuntary childlessness, a male infertility factor is involved. The PIWI-LIKE genes, a subclade of the Argonaute protein family, are involved in RNA silencing and transposon control in the germline. Knockout of murine Piwi-like 1 and 2 homologs results in complete infertility in males. Read More

    Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer.
    Asian J Androl 2017 Dec 29. Epub 2017 Dec 29.
    Department of Urology, University Hospital Tuebingen, Tuebingen 72076, Germany.
    Bone metastases have a major impact on quality of life and survival of patients with advanced prostate cancer. In the last decade, the development and approval of substances inhibiting the vicious cycle of bone metastases have enabled the reduction of complications caused by bone metastases in patients with castration-resistant prostate cancer. These drugs have raised awareness of the importance of skeletal-related events which in the meantime represent an important end point also in trials using agents not specifically designed for bone lesions. Read More

    Phosphoglycerate mutase 1 knockdown inhibits prostate cancer cell growth, migration, and invasion.
    Asian J Androl 2017 Dec 22. Epub 2017 Dec 22.
    Department of Urology, Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.
    Phosphoglycerate mutase 1 (PGAM1) is upregulated in many cancer types and involved in cell proliferation, migration, invasion, and apoptosis. However, the relationship between PGAM1 and prostate cancer is poorly understood. The present study investigated the changes in PGAM1 expression in prostate cancer tissues compared with normal prostate tissues and examined the cellular function of PGAM1 and its relationship with clinicopathological variables. Read More

    Intermittent, low-dose, antiandrogen monotherapy as an alternative therapeutic option for patients with positive surgical margins after radical prostatectomy.
    Asian J Androl 2017 Dec 22. Epub 2017 Dec 22.
    Department Urology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    The aim of the present study was to determine whether oncologic outcomes and adverse events associated with active on/off intermittent antiandrogen monotherapy (daily bicalutamide, 50 mg per day) are comparable with those of standard external beam radiation therapy (EBRT) or combined androgen blockade (CAB) therapy in prostate cancers with positive surgical margins after radical prostatectomy. Two hundred twenty-three patients with positive surgical margins post-radical prostatectomy who underwent active surveillance (AS, n = 32), EBRT without hormone therapy (n = 55), intermittent antiandrogen monotherapy without EBRT (IAAM, n = 50), or CAB without EBRT (n = 86), between 2007 and 2014, were reviewed retrospectively. Pathologic outcomes, biochemical recurrence rates, radiological disease progression, and adverse events were collected from medical records. Read More

    The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines.
    Asian J Androl 2017 Dec 19. Epub 2017 Dec 19.
    Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Independencia, Santiago 8380453, Chile.
    It has been reported that one of the factors that promotes tumoral progression is the abnormal activation of the epithelial-mesenchymal transition program. This process is associated with tumoral cells acquiring invasive and malignant properties and has the transcription factor zinc finger E-box-binding homeobox 1 (ZEB1) as one of its main activators. However, the role of ZEB1 in promoting malignancy in prostate cancer (PCa) is still unclear. Read More

    ASIC1a contributes to the symptom of pain in a rat model of chronic prostatitis.
    Asian J Androl 2017 Dec 8. Epub 2017 Dec 8.
    Department of Urology, Institute of Urology, Anhui Medical University, Hefei 230022, China.
    This study aims to validate our hypothesis that acid-sensing ion channels (ASICs) may contribute to the symptom of pain in patients with chronic prostatitis (CP). We first established a CP rat model, then isolated the L5-S2 spinal dorsal horn neurons for further studies. ASIC1a was knocked down and its effects on the expression of neurogenic inflammation-related factors in the dorsal horn neurons of rat spinal cord were evaluated. Read More

    Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice.
    Asian J Androl 2017 Dec 5. Epub 2017 Dec 5.
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
    Androgen deprivation in men leads to increased adiposity, but the mechanisms underlying androgen regulation of fat mass have not been fully defined. Androgen receptor (AR) is expressed in monocytes/macrophages, which are resident in key metabolic tissues and influence energy metabolism in surrounding cells. Male mice bearing a cell-specific knockout of the AR in monocytes/macrophages (M-ARKO) were generated to determine whether selective loss of androgen signaling in these cells would lead to altered body composition. Read More

    Association of subcutaneous testosterone pellet therapy with developing secondary polycythemia.
    Asian J Androl 2017 Dec 5. Epub 2017 Dec 5.
    Division of Urology, Brown University, Providence, RI 02903, USA.
    A variety of methods for testosterone replacement therapy (TRT) exist, and the major potential risks of TRT have been well established. The risk of developing polycythemia secondary to exogenous testosterone (T) has been reported to range from 0.4% to 40%. Read More

    Testosterone and its metabolites: differential associations with cardiovascular and cerebrovascular events in men.
    Asian J Androl 2017 Dec 1. Epub 2017 Dec 1.
    School of Medicine, University of Western Australia, Perth, Western Australia 6009, Australia.
    As men grow older, circulating testosterone declines while the incidence of cardiovascular disease increases. Thus, the role of sex hormones as biomarkers, and possibly contributing factors to clinical manifestations of cardiovascular disease in the increasing demographic of aging men, has attracted considerable interest. This review focuses on observational studies of endogenous androgens, namely circulating testosterone and dihydrotestosterone, which have examined their associations with cardiovascular events such as myocardial infarction and stroke. Read More

    Anprototype of a porcine biomimetic testis-like cell culture system: a novel tool for the study of reassembled Sertoli and Leydig cells.
    Asian J Androl 2017 Nov 10. Epub 2017 Nov 10.
    Division of Medical Andrology and Endocrinology of Reproduction, University of Perugia and Saint Mary Hospital, Terni 05100, Italy.
    At present, there is no reliable in vitro assembled prepubertal testis-like biomimetic organ culture system designed to assess the functional effects of human gonadotropins on Sertoli and Leydig cells. Spermatogenesis is regulated by endocrine, paracrine, and juxtacrine factors (testicular cross-talk), mainly orchestrated by gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that play a pivotal role by stimulating Leydig and Sertoli cells, respectively. The aim of our study was to set up an in vitro prepubertal porcine bioengineered construct as a new model for experimental studies on reassembled Sertoli and Leydig cells. Read More

    Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis.
    Asian J Androl 2017 Nov 7. Epub 2017 Nov 7.
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
    Previous studies have shown that oxidative stress and corporal fibrosis in penile tissues of rats were key pathological factors of erectile dysfunction induced by diabetic mellitus (DMED). Lipoxin A4 (LXA4) was reported to inhibit oxidative stress and fibrosis diseases, while whether it could exert a protective role on erectile function was not clear. Type I diabetic mellitus (DM) was induced in thirty male 10-week-old Sprague-Dawley rats using streptozotocin. Read More

    Transcription and regulation of hepatitis B virus genes in host sperm cells.
    Asian J Androl 2017 Nov 7. Epub 2017 Nov 7.
    Department of Genetics, Chengdu Jinxin Research Institute for Reproductive Medicine and Genetics, Chengdu 610066, China.
    To investigate whether transcription of hepatitis B virus (HBV) gene occurs in human sperm, total RNA was extracted from sperm of patients with chronic HBV infection (test-1), from donor sperm transfected with a plasmid containing the full-length HBV genome (test-2), and from nontransfected donor sperm (control), used as the template for reverse transcription-polymerase chain reaction (RT-PCR). Positive bands for HBV DNA were observed in the test groups but not in the control. Next, to identify the role of host genes in regulating viral gene transcription in sperm, total RNA was extracted from 2-cell embryos derived from hamster oocytes fertilized in vitro by HBV-transfected (test) or nontransfected (control) human sperm and successively subjected to SMART-PCR, suppression subtractive hybridization, T/A cloning, bacterial amplification, microarray hybridization, sequencing and the Basic Local Alignment Search Tool (BLAST) search to isolate differentially expressed genes. Read More

    External validation and newly development of a nomogram to predict overall survival of abiraterone-treated, castration-resistant patients with metastatic prostate cancer.
    Asian J Androl 2017 Nov 7. Epub 2017 Nov 7.
    Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
    Abiraterone acetate is approved for the treatment of castration-resistant prostate cancer (CRPC); however, its effects vary. An accurate prediction model to identify patient groups that will benefit from abiraterone treatment is therefore urgently required. The Chi model exhibits a good profile for risk classification, although its utility for the chemotherapy-naive group is unclear. Read More

    A retrospective review of single-institution outcomes with robotic-assisted microsurgical varicocelectomy.
    Asian J Androl 2017 Oct 27. Epub 2017 Oct 27.
    Urology Associates of Central Missouri, Columbia, MO 65201, USA.
    We report the largest single-center experience with robotic-assisted microscopic varicocelectomy (RAMV) in male infertility. From August 2012 to February 2015, men with infertility of at least a year and varicoceles underwent RAMV by a single surgeon. Varicocele was diagnosed on physical examination and confirmed by ultrasound by a single ultrasonographer. Read More

    Role of chemotherapy in prostate cancer.
    Asian J Androl 2017 Oct 20. Epub 2017 Oct 20.
    Genitourinary Medical Oncology, Inova Schar Cancer Institute, Fairfax, VA 22031, USA.
    Chemotherapy in prostate cancer (PCa) has undergone dramatic landscape changes. While earlier studies utilized varying chemotherapy regimens which were found to be largely palliative in nature and hardly resulted in durable or meaningful responses, docetaxel resulted in the first chemotherapy agent that showed improvement in overall survival in metastatic castration-resistant prostate cancer (mCRPC). However, combination chemotherapy or any agents added to docetaxel have failed to yield incremental benefits. Read More

    Radical prostatectomy in patients aged 75 years or older: review of the literature.
    Asian J Androl 2017 Sep 26. Epub 2017 Sep 26.
    Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg 20246, Germany.
    Given the demographic trends toward a considerably longer life expectancy, the percentage of elderly patients with prostate cancer will increase further in the upcoming decades. Therefore, the question arises, should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making, life expectancy is more important than biological age. As a result, a patient's health and mental status has to be determined and radical treatment should only be offered to those who are fit. Read More

    PSA time to nadir as a prognostic factor of first-line docetaxel treatment in castration-resistant prostate cancer: evidence from patients in Northwestern China.
    Asian J Androl 2017 Sep 12. Epub 2017 Sep 12.
    Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
    Docetaxel-based chemotherapy remains the first-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) in China; however, the prognostic factors associated with effects in these patients are still controversial. In this study, we retrospectively reviewed the data from 71 eligible Chinese patients who received docetaxel chemotherapy from 2009 to 2016 in our hospital and experienced a reduction of prostate-specific antigen (PSA) level ≥50% during the treatment and investigated the potential role of time to nadir (TTN) of PSA. TTN was defined as the time from start of chemotherapy to the nadir of PSA level during the treatment. Read More

    Proton-pump inhibitor use does not affect semen quality in subfertile men.
    Asian J Androl 2017 Sep 5. Epub 2017 Sep 5.
    Division of Urology, Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA.
    Proton-pump inhibitors (PPIs) are among the most widely used drugs worldwide. PPI use has recently been linked to adverse changes in semen quality in healthy men; however, the effects of PPI use on semen parameters remain largely unknown specifically in cases with male factor infertility. We examined whether PPI use was associated with detrimental effects on semen parameters in a large population of subfertile men. Read More

    Andrographolide sensitizes prostate cancer cells to TRAIL-induced apoptosis.
    Asian J Androl 2017 Sep 1. Epub 2017 Sep 1.
    Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for anticancer therapy. The identification of small molecules that can establish the sensitivity of prostate cancer (PCa) cells to TRAIL-induced apoptosis is crucial for the targeted treatment of PCa. PC3, DU145, JAC-1, TsuPr1, and LNCaP cells were treated with Andrographolide (Andro) and TRAIL, and the apoptosis was measured using the Annexin V/PI double staining method. Read More

    Antiarrhythmic drug usage and prostate cancer: a population-based cohort study.
    Asian J Androl 2018 Jan-Feb;20(1):37-42
    Department of Urology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 110, Taiwan, China.
    Even though the relationship between antiarrhythmic drug usage and subsequent prostate cancer (PCa) risk has recently been highlighted, relevant findings in the previous literature are still inconsistent. In addition, very few studies have attempted to investigate the association between sodium channel blockers or potassium channel blockers for arrhythmia and the subsequent PCa risk. Therefore, this cohort study aimed to find the relationship between antiarrhythmic drug usage and the subsequent PCa risk using a population-based dataset. Read More

    Circulating tumor cells and their role in prostate cancer.
    Asian J Androl 2017 Aug 22. Epub 2017 Aug 22.
    Department of Urology, University Hospital Tuebingen, Hoppe-Seyler-Straße 3, Tuebingen 72076, Germany.
    Circulating tumor cells (CTC) have become an important biomarker in patients with advanced prostate cancer. CTC count has been demonstrated to be a prognostic factor for overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC). In localized prostate cancer, a clear correlation between CTC counts and clinicopathological risk parameters and outcome has not been observed. Read More

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