16 results match your criteria Asian Journal Of Pharmaceutical Sciences[Journal]

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The Effect of Drug Content Reduction on the In Vitro and In Vivo Properties of Levonorgestrel-Releasing Intravaginal Rings.

J Pharm Sci 2018 04 23;107(4):1020-1027. Epub 2017 Nov 23.

Clinical Sciences, Bayer AG, Berlin, Germany.

Intravaginal rings (IVRs) are an option for continuous administration of drugs in women. However, a considerable amount of excess drug often remains in the ring upon removal. The current study focuses on comparing 2 IVRs releasing levonorgestrel (LNG). Read More

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http://dx.doi.org/10.1016/j.xphs.2017.11.009DOI Listing
April 2018
6 Reads

Plasma Lipidomics of Healthy Japanese Adults Reveals Gender- and Age-Related Differences.

J Pharm Sci 2017 09 8;106(9):2914-2918. Epub 2017 May 8.

Division of Medicinal Safety Science, National Institute of Health Sciences, Setagaya, Tokyo, Japan. Electronic address:

Lipid metabolites in the blood are expected to be biomarker candidates to reflect disease states and responses to therapeutic drugs. However, their profiles are influenced by subject background, which may lead to confounding results. This study aimed to evaluate whether age and gender affect lipid metabolite levels in the plasma of healthy Japanese adults. Read More

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http://dx.doi.org/10.1016/j.xphs.2017.05.002DOI Listing
September 2017
14 Reads

Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.

J Pharm Sci 2017 09 3;106(9):2751-2757. Epub 2017 Apr 3.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94143. Electronic address:

The Food and Drug Administration recommends rosuvastatin dosage reductions in Asian patients because pharmacokinetic studies have demonstrated an approximate 2-fold increase in median exposure to rosuvastatin in Asian subjects compared with Caucasian controls. Yet, no explanation for this ethnic difference has been confirmed. Here we show that rosuvastatin exposure in Asians and Whites does not differ significantly when all subjects are wild-type carriers for both solute carrier organic anion transporter 1B1 *1a and ATP-binding cassette subfamily G member 2 c. Read More

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http://dx.doi.org/10.1016/j.xphs.2017.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675025PMC
September 2017
16 Reads

Does pharmacist-supervised intervention through pharmaceutical care program influence direct healthcare cost burden of newly diagnosed diabetics in a tertiary care teaching hospital in Nepal: a non-clinical randomised controlled trial approach.

Daru 2016 Feb 29;24. Epub 2016 Feb 29.

Department of Pharmacy and Pharmacology, National Medical College, Birgunj, Nepal.

Background: Cost is a vital component for people with chronic diseases as treatment is expected to be long or even lifelong in some diseases. Pharmacist contributions in decreasing the healthcare cost burden of chronic patients are not well described due to lack of sufficient evidences worldwide. In developing countries like Nepal, the estimation of direct healthcare cost burden among newly diagnosed diabetics is still a challenge for healthcare professionals, and pharmacist role in patient care is still theoretical and practically non-existent. Read More

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http://dx.doi.org/10.1186/s40199-016-0145-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772684PMC
February 2016
11 Reads

Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis.

Daru 2015 Jul 4;23:35. Epub 2015 Jul 4.

College of Pharmacy, Duksung Women's University, Seoul, 132-714, Republic of Korea.

Background: Cordyceps militaris has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including an anti-cancer effect. We investigated the inhibitory effect of Cordyceps militaris ethanol extract on a human colorectal cancer-derived cell line, RKO. Read More

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http://dx.doi.org/10.1186/s40199-015-0117-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491205PMC
July 2015
9 Reads

Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8).

J Pharm Sci 2013 Sep 6;102(9):3451-7. Epub 2013 May 6.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.

Organic anion transporter 3 (OAT3, SLC22A8), a transporter expressed on the basolateral membrane of the proximal tubule, plays a critical role in the renal excretion of organic anions including many therapeutic drugs. The goal of this study was to evaluate the in vivo effects of the OAT3-Ile305Phe variant (rs11568482), present at 3.5% allele frequency in Asians, on drug disposition with a focus on cefotaxime, a cephalosporin antibiotic. Read More

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http://dx.doi.org/10.1002/jps.23581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151246PMC
September 2013
11 Reads

Development of a validated HPLC method for the simultaneous determination of flavonoids in Cuscuta chinensis Lam. by ultra-violet detection.

Daru 2012 Oct 16;20(1):57. Epub 2012 Oct 16.

Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME, Tehran, Iran.

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Background: Cuscuta species known as dodder, have been used in traditional medicine of eastern and southern Asian countries as liver and kidney tonic. Flavonoids are considered as the main biologically active constituents in Cuscuta plants especially in C. chinensis Lam. Read More

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http://link.springer.com/content/pdf/10.1186%2F2008-2231-20-
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http://www.herbmedpharmacol.com/PDF/JHP-3-119.pdf
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http://darujps.biomedcentral.com/articles/10.1186/2008-2231-
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http://dx.doi.org/10.1186/2008-2231-20-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555954PMC
October 2012
6 Reads

Functional consequences of genetic variations in the human organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population.

J Pharm Sci 2012 Mar 6;101(3):1302-13. Epub 2011 Dec 6.

Department of Pharmaceutics, College of Pharmacy, Seoul National University, Gwanak-gu, Seoul 151-742, Korea.

The objectives of this study were to investigate the allele frequencies and linkage disequilibrium (LD) in the organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population and to examine the functional consequences. Using samples from 48 Koreans, direct sequencing was carried out to determine the allele frequencies and LD of OATP1B3 in a representative Korean population. Thirty-six genetic variations in the transporter were found in Koreans; among them, five undocumented variations (i. Read More

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http://dx.doi.org/10.1002/jps.23005DOI Listing
March 2012
9 Reads

Genetic variations of orosomucoid genes associated with serum alpha-1-acid glycoprotein level and the pharmacokinetics of paclitaxel in Japanese cancer patients.

J Pharm Sci 2011 Oct 2;100(10):4546-59. Epub 2011 Jun 2.

National Institute of Health Sciences, Tokyo 158-8501, Japan.

Alpha-1-acid glycoprotein (AGP) encoded by orosomucoid genes (ORM1 and ORM2) is an acute-phase response protein and functions as a drug-binding protein that affects pharmacokinetics (PK)/pharmacodynamics of binding drugs. To explore the effects of genetic variations of ORMs and a role of AGP on paclitaxel (PTX) therapy, we analyzed the duplication and genetic variations/haplotypes of ORMs in 165 Japanese cancer patients and then investigated their associations with serum AGP levels and the PK parameters of PTX. No effects of ORM duplications on serum AGP levels at baseline or PK of PTX were observed, but close associations of ORM1 -559T > A with the increases of AGP levels and area under the curve (AUC) of PTX metabolites were detected. Read More

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http://dx.doi.org/10.1002/jps.22648DOI Listing
October 2011
28 Reads

Process-induced phase transformation of berberine chloride hydrates.

J Pharm Sci 2010 Apr;99(4):1942-54

School of Health Sciences, Macao Polytechnic Institute, Macao, China.

Berberine is a natural quaternary ammonium alkaloid used clinically in the chloride salt form for the treatment of diarrhea in many Asian countries. Although the hydrate formation of berberine chloride (BCl) is well documented, the associated mechanism and implications in pharmaceutical formulation have not been studied in detail. In this study, pure BCl dihydrate and BCl tetrahydrate were recrystallized from water and their phase transformation behaviors under defined conditions were investigated. Read More

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http://dx.doi.org/10.1002/jps.21983DOI Listing
April 2010
38 Reads

Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population.

J Pharm Sci 2004 Dec;93(12):2920-6

Division of Pharmaceutical Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan.

The organic cation transporter OCTN1 (SLC22A4) is expressed ubiquitously, with strong expression in kidney, trachea, bone marrow, and fetal liver, and it mediates transport of organic cations in a pH-dependent manner. Recent studies have identified single nucleotide polymorphisms (SNPs) of OCTN1 in the Japanese population. Two SNPs present in the exon regions, c1063t and g1531a, cause amino acid mutation, Thr306Ile (T306I) and Gly462Glu (G462E), respectively. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S002235491639322
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http://dx.doi.org/10.1002/jps.20190DOI Listing
December 2004
1 Read

Evaluation of in vivo bioequivalence methodology for topical clobetasol 17-propionate based on pharmacodynamic modeling using Chinese skin.

J Pharm Sci 2004 Jan;93(1):207-17

Institute of Clinical Pharmacy, College of Medicine, National Cheng Kung University, Tainan, 1 University Road, Tainan, Taiwan 70101.

The United States Food and Drug Administration recommends pilot dose duration-response and pivotal bioequivalence studies to be conducted using reflectance colorimetry for assessment of the in vivo bioequivalence of topical dermatologic corticosteroids. The major objectives of the present studies were to examine the applicability of the standardized pharmacodynamic modeling-based methodology to super-potent clobetasol 17-propionate (CP) in the Chinese population and to evaluate the bioequivalence of two generic ointments and four generic creams containing 0.05% (w/w) CP with respect to Dermovate formulations using such methodology. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S002235491631386
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http://dx.doi.org/10.1002/jps.10536DOI Listing
January 2004
6 Reads

Metabolic deesterification of tazarotene in human blood and rat and human liver microsomes.

J Pharm Sci 1997 Aug;86(8):972-4

Department of Pharmacokinetics & Drug Metabolism, Allergan, Irvine, CA 92623, USA.

Tazarotene is a novel acetylenic retinoid for the treatment of psoriasis and acne. We examined (1) the hydrolysis of tazarotene in blood from Japanese-American and Caucasian subjects, (2) the esterases responsible for this hydrolysis in human blood, and (3) tazarotene hydrolysis in rat and human liver microsomes. Tazarotene hydrolysis and enzyme inhibition were assessed by monitoring the disappearance of tazarotene and the appearance of its primary metabolite tazarotenic acid by HPLC. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S002235491550364
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http://dx.doi.org/10.1021/js9700558DOI Listing
August 1997
5 Reads

Pharmacokinetics of enoximone after various intravenous administrations to healthy volunteers.

J Pharm Sci 1995 Feb;84(2):152-7

Marion Merrell Dow Development Laboratories, Hirakata Center, Osaka, Japan.

The pharmacokinetics of enoximone and its sulfoxide metabolite were investigated in healthy male volunteers after various intravenous administrations: a bolus single dose, a continuous infusion, and bolus multiple doses of enoximone. The overall pharmacokinetic profiles of enoximone and sulfoxide metabolite indicated linearity over the range of 0.25-2. Read More

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February 1995

Simulation studies on ethanol metabolism in different human populations with a physiological pharmacokinetic model.

Authors:
R F Derr

J Pharm Sci 1993 Jul;82(7):677-82

Research Service, VA Medical Center, Minneapolis, MN 55417.

A physiological pharmacokinetic model of ethanol metabolism was used to simulate ethanol metabolism in standard, fasted, human males of the white American, white European, black American, and Japanese populations. Gastric ethanol metabolism accounted for only 0.24% of the dose in the several populations. Read More

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Corneal absorption reinforcement of certain mydriatics.

J Pharm Sci 1970 Nov;59(11):1559-63

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November 1970
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