6 results match your criteria Asian Journal Of Organic Chemistry[Journal]

  • Page 1 of 1

Ammonium Ylide Mediated Cyclization Reactions.

Asian J Org Chem 2018 May 25;7(5):852-864. Epub 2018 Mar 25.

Institute of Organic Chemistry, Johannes Kepler University Linz Altenbergerstr. 69 4040 Linz (Austria).

The use of readily accessible ammonium ylides for (asymmetric) transformations, especially cyclization reactions, has received considerable attention over the past two decades. A variety of highly enantioselective protocols to facilitate annulation reactions have recently been introduced as an alternative to other common methods including S-ylide-mediated strategies. It is the intention of this short review to provide an introduction to this field by highlighting the potential of ammonium ylides for (asymmetric) cyclization reactions as well as to present the limitations and challenges of these methods. Read More

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http://dx.doi.org/10.1002/ajoc.201800091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130843PMC
May 2018
2 Reads

Syntheses of Highly Functionalized Spirocyclohexenes by Formal [4+2] Annulation of Arylidene Azlactones with Allenoates.

Asian J Org Chem 2018 Aug 4;7(8):1620-1625. Epub 2018 May 4.

Johannes Kepler University Linz, Institute of Organic Chemistry, Altenbergerstrasse 69, 4040 Linz (Austria).

A straightforward phosphine-catalyzed formal [4+2] annulation between α-branched allenoates and arylidene azlactones has been developed to access highly functionalized spirocyclohexenes. This cyclization favors the γ-addition of the phosphine-activated allenoates over a β'-addition pathway. Detailed computational studies support the proposed mechanism and provide a reasonable explanation for the observed regioselectivity and the noted effect of the catalyst. Read More

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http://doi.wiley.com/10.1002/ajoc.201800275
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http://dx.doi.org/10.1002/ajoc.201800275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114148PMC
August 2018
11 Reads

Recent Developments in Pd(0)-Catalyzed Alkene Carboheterofunctionalization Reactions.

Asian J Org Chem 2017 Jun 10;6(6):636-653. Epub 2017 Mar 10.

Department of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, MI, 48109-1055, USA.

This review summarizes recent developments in palladium-catalyzed alkene carboalkoxylation and carboamination reactions. New synthetic methods that have been reported in the past four years are described, along with mechanistic issues and the influence of mechanism on product stereochemistry. The applications of these transformations to the synthesis of natural products and other biologically relevant compounds are also discussed. Read More

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http://dx.doi.org/10.1002/ajoc.201600577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675590PMC

Chiral Brønsted Acid Catalyzed Kinetic Resolutions.

Asian J Org Chem 2016 Mar 7;5(3):308-320. Epub 2016 Mar 7.

K. Petersen, Department of Chemistry and Biochemistry, University of North Carolina at Greensboro Greensboro, Greensboro, NC 27412.

The synthesis of enantioenriched small molecules is an ongoing goal of organic chemists. This focus review explores the use of kinetic resolutions catalyzed by chiral Brønsted acids. Methods include classic kinetic resolutions and dynamic kinetic resolutions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077028PMC
http://dx.doi.org/10.1002/ajoc.201600021DOI Listing
March 2016
2 Reads

Rapid Construction of (-)-Paroxetine and (-)-Femoxetine via -Heterocyclic Carbene Catalyzed Homoenolate Addition to Nitroalkenes.

Asian J Org Chem 2014 Apr;3(4):442-444

Department of Chemistry, Colorado State University, Fort Collins, CO 80523 (USA).

A concise enantioselective synthesis of (-)-paroxetine () and (-)-femoxetine has been achieved. Key to these syntheses is a -heterocyclic carbene catalyzed homoenolate addition to a nitroalkene followed by in situ reduction of the nitro-group to rapidly access δ-lactams. Read More

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http://dx.doi.org/10.1002/ajoc.201402031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251551PMC
April 2014
20 Reads

Phosphine-Initiated General-Base-Catalyzed Quinolone Synthesis.

Asian J Org Chem 2014 Apr;3(4):453-457

Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Dr. East, Los Angeles, California 90095-1569 (USA).

Phosphinocatalysis provides a new approach toward 3-substituted-4-quinolones. A simple procedure, which uses PhP as an inexpensive catalyst and -phenyl 2-(-tosylamido)benzothioates and activated alkynes as starting materials, provides direct access to several 3-aroyl-4-quinolones and methyl 4-quinolone-3-carboxylate esters. The reaction presumably occurs through general base catalysis, with the initial addition of PhP to the activated alkyne generating the phosphonium enoate zwitterion, which acts as the strong base that initiates the reaction. Read More

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http://dx.doi.org/10.1002/ajoc.201402039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509642PMC
April 2014
2 Reads
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