186,145 results match your criteria Asian Economic Papers[Journal]


Factors related to heavy drinking between British Columbia Asian adolescents and South Korean adolescents.

J Spec Pediatr Nurs 2020 May 27:e12296. Epub 2020 May 27.

Stigma and Resilience Among Vulnerable Youth Centre, School of Nursing, University of British Columbia, Vancouver, British Columbia, Canada.

Purpose: The aim of this study is to compare the factors related to heavy drinking among British Columbia (BC) Asian adolescents and South Korean adolescents.

Design And Methods: A cross-sectional descriptive design was used. Participants were 72,422 adolescents (12,382 BC Asian adolescents and 60,040 South Korean adolescents) from the 2018 BC Adolescent Health Survey and the 2018 Korean Youth Risk Behavior Web-Based Survey. Read More

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http://dx.doi.org/10.1111/jspn.12296DOI Listing

Influence of maternal region of birth on neonatal outcomes of babies born small.

Acta Paediatr 2020 May 27. Epub 2020 May 27.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.

Aim: To compare neonatal outcomes of Small for Gestational Age (SGA) infants born to South Asian (SA)-born women, and Australia New Zealand (ANZ)-born women.

Methods: Retrospective cohort study at a hospital network in Australia. Maternal and neonatal data was collected for infants born SGA between 2013-2017 to SA or ANZ-born women. Read More

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http://dx.doi.org/10.1111/apa.15375DOI Listing

Sublingual buprenorphine-naloxone precipitated withdrawal-A case report with review of literature and clinical considerations.

Asian J Psychiatr 2020 May 16;53:102121. Epub 2020 May 16.

National Drug Dependence TreatMent Centre, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Buprenorphine- Naloxone Fixed Dose Combination (BNX) is widely used to manage opioid use disorders. Contrary to evidence based concepts about sublingual bio-availability of naloxone, a few small studies have reported non-negligible amounts absorbed sublingually. But the extent to which these amounts exert opioid antagonist effects is yet to be established. Read More

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http://dx.doi.org/10.1016/j.ajp.2020.102121DOI Listing

Hospitalization and Mortality among Black Patients and White Patients with Covid-19.

N Engl J Med 2020 May 27. Epub 2020 May 27.

From the Ochsner Health Center for Outcomes and Health Services Research (E.G.P.-H., J.B., D.F.) and the University of Queensland Ochsner Clinical School (E.G.P.-H., L.S.) - both in New Orleans.

Background: Many reports on coronavirus disease 2019 (Covid-19) have highlighted age- and sex-related differences in health outcomes. More information is needed about racial and ethnic differences in outcomes from Covid-19.

Methods: In this retrospective cohort study, we analyzed data from patients seen within an integrated-delivery health system (Ochsner Health) in Louisiana between March 1 and April 11, 2020, who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the virus that causes Covid-19) on qualitative polymerase-chain-reaction assay. Read More

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http://dx.doi.org/10.1056/NEJMsa2011686DOI Listing

The association between polymorphism of norepinephrine transporter G1287A and major depressive disorder, antidepressant response: a meta-analysis.

Psychiatr Genet 2020 May 23. Epub 2020 May 23.

Department of Psychiatry, Zhengzhou University First Affiliated Hospital, Zhengzhou, Henan Province.

Objectives: Massive research has examined the cause of major depressive disorder (MDD) and accumulating evidence has revealed that the gene for the norepinephrine transporter (NET) is involved in MDDs etiology as well as the antidepressant response. The G1287A (rs5569, GRCh38, Chromosome 16, 55697923) is located in the exon 9 region of the SLC6A2 gene. It was found to be connected with MDD and antidepressant response in people of different genetic ancestries. Read More

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http://dx.doi.org/10.1097/YPG.0000000000000254DOI Listing

Reactions to an Online Demonstration of the Effect of Increased Fruit and Vegetable Consumption on Appearance: Survey.

J Med Internet Res 2020 May 14. Epub 2020 May 14.

Perception Lab, School of Psychology & Neuroscience, University of St Andrews, St Mary's QuadSouth Street, St Andrews, GB.

Background: Inadequate fruit and vegetable consumption causes a considerable disease burden and premature mortality. Despite considerable public health promotion of a healthy diet the average consumption is still below recommended levels. Fruit and vegetable consumption influences human skin colour, increasing red/yellow/orange pigment in the skin. Read More

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http://dx.doi.org/10.2196/15726DOI Listing

Electronic nicotine delivery system (ENDS) use patterns and its associations with cigarette smoking and nicotine addiction among Asian Americans: Findings from the national adult tobacco survey (NATS) 2013-2014.

J Ethn Subst Abuse 2020 May 27:1-19. Epub 2020 May 27.

University of Maryland, College Park, Maryland, USA.

This study examined the ENDS use and their associations with conventional cigarette smoking and nicotine addiction among Asian Americans (AAs). The study sample was restricted to Non-Hispanic AAs ( = 1,956) using the National Adult Tobacco Survey (NATS) 2013-2014. Chi-square tests and logistic regressions were employed. Read More

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http://dx.doi.org/10.1080/15332640.2020.1747039DOI Listing

Association of Salivary Cholinesterase With Arthropod Vectors of Disease.

J Med Entomol 2020 May 27. Epub 2020 May 27.

Knipling-Bushland U.S. Livestock Insects Research Laboratory, USDA-ARS, Kerrville, TX.

Acetylcholinesterase (AChE) was previously reported to be present in saliva of the southern cattle tick, Rhipicephalus (Boophilus) microplus (Canestrini), with proposed potential functions to 1) reduce acetylcholine toxicity during rapid engorgement, 2) modulate host immune responses, and 3) to influence pathogen transmission and establishment in the host. Potential modulation of host immune responses might include participation in salivary-assisted transmission and establishment of pathogens in the host as has been reported for a number of arthropod vector-borne diseases. If the hypothesis that tick salivary AChE may alter host immune responses is correct, we reasoned that similar cholinesterase activities might be present in saliva of additional arthropod vectors. Read More

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http://dx.doi.org/10.1093/jme/tjaa096DOI Listing

The associations between serum vitamin D, calcium and uterine fibroids in Chinese women: a case-controlled study.

J Int Med Res 2020 May;48(5):300060520923492

Department of Obstetrics and Gynaecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objective: To investigate the associations between serum vitamin D, calcium and uterine fibroids in a Chinese female population.

Methods: In this case-control study, adult female patients with fibroids (cases) were compared with females without fibroids (controls) in terms of serum 25-hydroxyvitamin D (25OHD) and calcium levels.

Results: Out of 546 total participants (mean age, 41. Read More

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http://dx.doi.org/10.1177/0300060520923492DOI Listing

GLOBAL Leukemia in Children 0-14 Statistics 2018, Incidence and Mortality and Human Development Index (HDI): GLOBOCAN Sources and Methods.

Asian Pac J Cancer Prev 2020 May 1;21(5):1487-1494. Epub 2020 May 1.

Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Objective: Cancer is the second leading cause of death in children under 15 and leukemia is the most common type of cancer in this age group.  The aim of the present study is to investigate the incidence and mortality of leukemia in children aged 0-14 years and its relationship with Human Development Index (HDI in different countries of the world.  Methods: Incidence and mortality rates were obtained from GLOBOCAN and Country's income from World Bank. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1487DOI Listing

Patterns of Care and Outcome Analysis of Nasopharyngeal Carcinoma: An Indonesian Single Institution Study.

Asian Pac J Cancer Prev 2020 May 1;21(5):1481-1485. Epub 2020 May 1.

Department of Ear, Nose and Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Background: Nasopharyngeal cancer is endemic to Southeast Asia. However, there is limited clinical evidence of nasopharyngeal cancer in Indonesia, which has the largest population in Southeast Asia.

Methods: Patterns of care and treatment outcomes in 428 patients with newly-diagnosed and pathologically-confirmed nasopharyngeal cancer were retrospectively analyzed. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1481DOI Listing

Microsatellite Instability and Life Style Factors in Sporadic Colorectal Cancer.

Asian Pac J Cancer Prev 2020 May 1;21(5):1471-1480. Epub 2020 May 1.

Pathology Department, NCI, Cairo University, Egypt.

Background: Colorectal cancer (CRC) in Egypt is a relatively high young onset disease. As a form of heterogeneous cancer, there is interplay between genetic and environmental factors. We aimed at probing the association of life style factors and Microsatellite Instability (MSI) status that could provide more insights on carcinogenic process of CRC. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1471DOI Listing

Expression of HER-2/neu in Oral Squamous Cell Carcinoma.

Asian Pac J Cancer Prev 2020 May 1;21(5):1465-1470. Epub 2020 May 1.

Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Research Chair for Biological Research in Dental Health, Riyadh, Saudi Arabia.

Background: HER-2/neu is a member of the human epidermal growth factor (HER) family of transmembrane tyrosine kinases, which is significantly associated with the pathogenesis of various cancer types. The aim was to evaluate the expression of HER-2/neu in oral squamous cell carcinoma (OSCC) as a potential biomarker to target antigens for specific immunotherapy in OSCC.

Methods: One hundred and forty histologically diagnosed OSCC cases were identified. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1465DOI Listing

Co-existing of HSV1/2 or EBV Infection with the Presence of High-Risk HPV DNA in Cervical Lesions in the Southwest of Iran.

Asian Pac J Cancer Prev 2020 May 1;21(5):1459-1464. Epub 2020 May 1.

Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: While the vast majority of the cervical lesions have been attributed to the HPVs, the role of EBV and HSV1/2 as co-factors in the progression of these abnormalities needs more investigation. In this study, we aimed to determine the co-existence of EBV or HSV in cervical lesions infected with high-risk HPVs.

Methods: Totally, 102 formaline-fixed cervical lesions with different pathological grades (LSIL, HSIL, and SCC) were enrolled in this study. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1459DOI Listing

LAT1 (SLC7A5) Overexpression in Negative Her2 Group of Breast Cancer: A Potential Therapy Target.

Asian Pac J Cancer Prev 2020 May 1;21(5):1453-1458. Epub 2020 May 1.

Department of Pathology, Jordan University of Science and Technology, Irbid, Jordan.

Objective: HER2 negative carcinomas of the breast pose a challenge for treatment due to redundancies in potential drug targets and poor patient outcomes. Our aim was to investigate the role of L-type amino acid transporter - LAT1 as a potential prognosticator and a drug target.

Methods: In this retrospective work, we have studied the expression of LAT1 in 145 breast cancer tissues via immunohistochemistry. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1453DOI Listing

Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population.

Asian Pac J Cancer Prev 2020 May 1;21(5):1445-1451. Epub 2020 May 1.

Department of Pharmacy, BGC Trust University Bangladesh, Chandanaish, Chittagong-4381, Bangladesh.

Objectives: In case of Bangladeshi population, no report is observed till now showing the genetic variations of RAD51 (rs1801320) and XRCC2 (rs3218536) genes polymorphism having association with colorectal cancer risk. For this reason the aim of this study is to ascertain their interrelation with colorectal cancer occurrence in Bangladeshi population.

Materials And Methods: A case control study was conducted where 200 colorectal cancer patients and 200 healthy volunteers were figured for this research using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1445DOI Listing

Effectiveness of a Transanal Drainage Tube for the Prevention of Anastomotic Leakage after Laparoscopic Low Anterior Resection for Rectal Cancer.

Asian Pac J Cancer Prev 2020 May 1;21(5):1441-1444. Epub 2020 May 1.

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China.

Background And Objective: Anastomotic leakage is one of the most serious complications after laparoscopic low anterior resection Low Anterior Resection (LAR) for rectal cancers. The purpose of this study was to evaluate the effectiveness of a transanal drainage tube placed for the prevention of anastomotic leakage after laparoscopic LAR.

Methods: The clinical data of 220 patients with rectal cancer who underwent laparoscopic LAR using the double stapling technique Double Stapling Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Technique (DST) from Jun 2017 to Dec 2018 were analyzed retrospectively at our institution. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1441DOI Listing

Simultaneous Effects of Viral Factors of Human Papilloma Virus and Epstein-Barr Virus on Progression of Breast and Thyroid Cancers: Application of Structural Equation Modeling.

Asian Pac J Cancer Prev 2020 May 1;21(5):1431-1439. Epub 2020 May 1.

Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

This study aimed to assess effects of the sets of EBV and HPV expressed proteins simultaneously on the sets of cellular/inflammatory factors in breast and thyroid cancers using structural equation modeling. In this multi-center case-control study, according to the inclusion and exclusion criteria, 83 breast and 57 thyroid specimens were collected from the eligible patients. In addition, 31 and 18 histopathological evaluated normal breast and thyroid samples were also examined as age-matched healthy controls. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1431DOI Listing

Factors that Affected Women Undergoing Cryotherapy Following Cancer Screening with Visual Inspection of the Cervix Using Acetic Acid Method.

Asian Pac J Cancer Prev 2020 May 1;21(5):1423-1429. Epub 2020 May 1.

Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr Sardjito General Hospital, Yogyakarta, Indonesia.

Background: The Indonesian government has applied the cancer "see and treat" method which involves a visual inspection using acetic acid (VIA), followed by a cryotherapy procedure, to reduce the incidence of cervical cancer. However, compliance with the program is still low in the targeted population. This study aims to see what factors influence women to receive cryotherapy treatment if they have positive VIA result. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1423DOI Listing

Awareness of Breast Cancer among Female Students and Faculty from Najran University, Najran, Saudi Arabia.

Asian Pac J Cancer Prev 2020 May 1;21(5):1415-1422. Epub 2020 May 1.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Background: Breast cancer (BC) is the leading malignancy among women in Najran, Saudi Arabia. However, not much is known about the public's awareness of BC. This study explored the general knowledge, early warning signs, risk factors and sources of information about BC. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1415DOI Listing

Prevalence and Antibiotic Resistance Patterns of Helicobacter pylori Infection in Koh Kong, Cambodia.

Asian Pac J Cancer Prev 2020 May 1;21(5):1409-1413. Epub 2020 May 1.

Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.

Background: Gastric cancer, which is the leading cause of cancer mortality in Cambodia, can be prevented by Helicobacter pylori (H. pylori) eradication. There is limited data about H. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1409DOI Listing

Accelerated Radiotherapy with Concurrent Chemotherapy in Locally Advanced Head and Neck Cancers: Evaluation of Response and Compliance.

Asian Pac J Cancer Prev 2020 May 1;21(5):1399-1407. Epub 2020 May 1.

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.

Purpose: Concurrent chemo-radiotherapy (CCRT) is the primary treatment modality for locally advanced head and neck squamous cell cancer patients (LAHNSCC). Intensity modulated radiotherapy (IMRT) with simultaneous integrated boost (SIB) and concurrent chemotherapy is not broadly implicated in our region mainly because of the lack of experience. This study aims at evaluating the response and compliance of this approach in our patients. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1399DOI Listing

A Prospective Randomized Trial to Compare Safety, Acceptability and Efficacy of Thermal Ablation and Cryotherapy in a Screen and Treat Setting.

Asian Pac J Cancer Prev 2020 May 1;21(5):1391-1398. Epub 2020 May 1.

International Agency for Research on Cancer, Lyon, France.

Background: The prospective randomized study aimed to compare the safety, acceptability and efficacy of thermal ablation (TA) to that of cryotherapy in screen and treat setting.

Methods: The participants were recruited prospectively in a community-based screening clinic in India. Women positive on visual inspection with acetic acid (VIA) test and/or Human Papillomavirus (HPV) test were assessed for eligibility for ablative treatment. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1391DOI Listing

Evaluation of the Biological Efficiency of Silver Nanoparticles Biosynthesized Using Croton tiglium L. Seeds Extract against Azoxymethane Induced Colon Cancer in Rats.

Asian Pac J Cancer Prev 2020 May 1;21(5):1369-1389. Epub 2020 May 1.

Animal Reproduction and Artificial Insemination Department, Veterinary Division, National Research Centre, Dokki, Giza, Egypt .

Background: Colorectal cancer (CRC) is considered as the most common type of gastrointestinal cancers. Chemotherapy became limited due to the adverse side effects. Therefore, the most effective Croton tiglium extract was selected to be incorporated by silver nanoparticles (Ag-NPs) then evaluated against colon cancer induced by azoxymethane (AOM) in rats. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1369DOI Listing

Association between Healthy Eating Index-2015 and Breast Cancer Risk: A Case-Control Study.

Asian Pac J Cancer Prev 2020 May 1;21(5):1363-1367. Epub 2020 May 1.

Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: Diet quality is known to influence cancer risk. The Healthy Eating Index (HEI) is one of the most frequently used measures of diet quality. However, the association between HEI-2015 and breast cancer risk is not known. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1363DOI Listing

Understanding Facilitators and Barriers of Online Cancer Information Utilization among Cancer Survivors and their Families: Focus on the Theory of Planned Behavior.

Asian Pac J Cancer Prev 2020 May 1;21(5):1357-1362. Epub 2020 May 1.

Department of Health Management and Policy, School of Medicine, Kangwon National University, Republic of Korea.

Objective: Cancer survivors have various health care needs and are willing to be proactive with their health maintenance. Online information would be a useful resource to guide cancer survivors and their family members. Therefore, identifying the factors that influence Internet searching behaviors among cancer survivors and their family members is a first step toward providing better health care services for cancer care. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1357DOI Listing

Structural Recognition and Binding Pattern Analysis of Human Topoisomerase II Alpha with Steroidal Drugs: In Silico Study to Switchover the Cancer Treatment.

Asian Pac J Cancer Prev 2020 May 1;21(5):1349-1355. Epub 2020 May 1.

Department of Health Informatics, College of Public Health and Health Informatics, Qassim University, Saudi Arabia.

Background And Objective: Topoisomerase TOP-IIA (TTOP-IIA) is widely used as a significant target for cancer therapeutics because of its involvement in cell proliferation. Steroidal drugs have been suggested for breast cancer treatment as aromatase enzymes inhibitors . TTOP-IIA inhibitors can be used as a target for the development of new cancer therapeutics. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1349DOI Listing

Barriers and Attitudes toward Breast Cancer Screening among Omani Women.

Asian Pac J Cancer Prev 2020 May 1;21(5):1339-1347. Epub 2020 May 1.

Research Section, Medical Simulation and Skills Development Centre, Oman Medical Specialty Board, Muscat, Sultanate of Oman.

Background: Breast cancer (BC) is the most common cancer accounting for 24.5% of Omani female cancer. Early detection of BC through regular breast cancer screening (BCS) has been found to decrease mortality rates. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1339DOI Listing

Evaluation of Antibiotic Resistance and Virulence Genes among Clinical Isolates of Pseudomonas aeruginosa from Cancer Patients.

Asian Pac J Cancer Prev 2020 May 1;21(5):1333-1338. Epub 2020 May 1.

Department of Microbiology, University of Central Punjab Lahore, Pakistan.

Objectives: The objectives of this study were to evaluate P. Aeruginosa isolates from cancer patients for the phenotypic pattern of antibiotic resistance and to detect the gene responsible for virulence as well as antibiotic resistance.

Methods: A total of 227 P. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1333DOI Listing

Sequential Chemoradiotherapy Compared to Radiotherapy in Endometrial Carcinoma.

Asian Pac J Cancer Prev 2020 May 1;21(5):1327-1332. Epub 2020 May 1.

Oncology Center, King Abdullah Medical City, Makkah, Saudi Arabia.

Background: The role of combined modality in the adjuvant treatment of Endometrial Cancer has not been established. This study aims to assess the benefits of Sequential Chemoradiotherapy (SCRT) compared to Radiotherapy (RT) alone in the treatment of patients with Endometrial Cancer.

Methods: Retrospective analysis of patients with Endometrial Cancer stage I to stage III C at King Abdullah Medical city, Makkah. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1327DOI Listing

Epidemiologic and Health Economic Evaluation of Cervical Cancer Screening in Rural China.

Asian Pac J Cancer Prev 2020 May 1;21(5):1317-1325. Epub 2020 May 1.

West China School of Public Health and West Fourth Hospital, Sichuan University, Chengdu, China.

Background: Cervical cancer is preventable and curable by detected early and managed effectively. To explore the most economical and effective cervical cancer screening strategies would lay a solid foundation for reducing the health and economic burden of cervical cancer.

Methods: A Markov model was established for a cohort of 100,000 female to simulate the natural history of cervical cancer. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1317DOI Listing

Aberrant Expression of miR-103, miR-184, miR-378, miR-497 and miR-506 in Tumor Tissue from Patients with Oral Squamous Cell Carcinoma Regulates the Clinical Picture of the Patients.

Asian Pac J Cancer Prev 2020 May 1;21(5):1311-1315. Epub 2020 May 1.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: This study aimed to evaluate the expression patterns of miR-103, miR-184, miR-378, miR497 and in squamous cell carcinoma (SCC) of the tongue and to be compared with normal peripheral tissues.

Methods: Tumor and marginal tissues were obtained from 50 patients with OSCC. After RNA extraction, expression level of miR-103, miR-184, miR-378, miR497, and miR506 was estimated using SYBR green master mix and real-time quantitative PCR. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1311DOI Listing

Occupational Exposure and Risk Assessment of Formaldehyde in the Pathology Departments of Hospitals.

Asian Pac J Cancer Prev 2020 May 1;21(5):1303-1309. Epub 2020 May 1.

Department of Occupational Health, School of Health, Guilan University of Medical Sciences, Rasht, Iran.

Background And Objective: Exposure to formaldehyde has adverse effects on health both acutely and over the long term (e.g., carcinogenicity). Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1303DOI Listing

Clinical Value of NOTCH1 Mutations Detection among Chronic Lymphocytic Leukemia Patients.

Asian Pac J Cancer Prev 2020 May 1;21(5):1295-1301. Epub 2020 May 1.

Hematology Unit, Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura University, Egypt.

Background: The data about the clinical impact of NOTCH1 mutations among Egyptians B - cell chronic lymphocytic patients is not previously identified. We herein, evaluate the prevalence and the prognostic significance of neurogenic locus notch homolog protein-1 (NOTCH1) mutations in B- cell lymphocytic leukemia (B-CLL).

Methods: A cohort of 105 Egyptian B-CLL patients aging from 43 to 86 years. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1295DOI Listing

Modulatory Role of Single Nucleotide Polymorphisms of Distinct Genetic Pathways on Clinical Behavior of Medullary Thyroid Carcinoma.

Asian Pac J Cancer Prev 2020 May 1;21(5):1289-1293. Epub 2020 May 1.

Sarin Lab, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India.

Background: Role of RET proto-oncogene as predisposing gene for Medullary Thyroid Carcinoma is well established which provides the basis for clinical management of patients. However clinical behavior of MTC varies considerably among patients. Several studies have investigated whether SNPs in low penetrance genes could modulate the clinical behavior of MTC but with conflicting or inconclusive results. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1289DOI Listing

Promoter Hypermethylation of LATS2 Gene in Oral Squamous Cell Carcinoma (OSCC) Among North Indian Population.

Asian Pac J Cancer Prev 2020 May 1;21(5):1283-1287. Epub 2020 May 1.

Department of Biotechnology, Institute of Applied Medicines and Research Ghaziabad, Uttar Pradesh, India.

ABSTRACT
Large Tumor Suppressor (LATS2) gene are Tumor Suppressor gene, linked with epigenetic modifications. LATS2 promoter hypermethylation is an important epigenetic silencing mechanism leading to cancer. Cancer is the most common, vicious and dangerously increasing diseases of the world today, associated with high morbidity and mortality. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1283DOI Listing

Ethanol Extract of Hizikia fusiforme Induces Apoptosis in B16F10 Mouse Melanoma Cells through ROS-Dependent Inhibition of the PI3K/Akt Signaling Pathway.

Asian Pac J Cancer Prev 2020 May 1;21(5):1275-1282. Epub 2020 May 1.

Anti-Aging Research Center, Dong-eui University, Busan 47340, Republic of Korea.

Background: Previous studies have reported that Hizikia fusiforme, an edible brown seaweed, has diverse health-promoting effects; however, evidence for its anti-cancer potential is still lacking. In this study, we examined the effect of ethanol extract of H. fusiforme (EHF) on the proliferation of B16F10 mouse melanoma cells. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1275DOI Listing

Reversal Effect of Dihydromyricetin on Multiple Drug Resistance in SGC7901/5-FU Cells.

Asian Pac J Cancer Prev 2020 May 1;21(5):1269-1274. Epub 2020 May 1.

Department of Biochemistry, Wannan Medical College, Wuhu, Anhui, P.R.China.

Background: One of the most common treatment for gastric cancer is chemotherapy, however, multiple drug resistance (MDR) induce the therapeutic effect which result in the failure of anticancer therapy. Dihydromyricetin (DMY) was reported to have antitumor activities on various human cancer cells in vitro, our previous studies demonstrated that DMY combined with mitomycin has inhibitory effect on proliferation of gastric carcinoma cells. However, the underlying role of DMY reversing the MDR of gastric carcinoma is poor understood. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1269DOI Listing

Cytotoxic and Antimetastatic Activity of Hesperetin and Doxorubicin Combination Toward Her2 Expressing Breast Cancer Cells.

Asian Pac J Cancer Prev 2020 May 1;21(5):1259-1267. Epub 2020 May 1.

Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.

Objective: This study aimed to explore Hesperetin (Hst) potency as a co-chemotherapeutics agent combined with Doxorubicin (Dox), particularly cytotoxic and antimetastasis effects toward MCF-7/HER2 cells.

Methods: The cytotoxic effects were measured under MTT assay. The flowcytometry analysis was used to examine the cell cycle modulation and apoptosis evidence, while the effect of migration was assayed by scratch wound healing assay. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1259DOI Listing

Perceived Deterrence Towards Colonoscopy for Colorectal Cancer Screening among Northern Malaysia Population: A Qualitative Study.

Asian Pac J Cancer Prev 2020 May 1;21(5):1253-1258. Epub 2020 May 1.

Clinical Research Center, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia.

Background: Patients with positive immunochemical faecal occult blood test results were found to have poor compliance for a subsequent colonoscopy procedure. This study was conducted to explore patients' perceived deterrence for colonoscopy following a positive stool test.

Methods: Using qualitative study method, a phone interview was conducted with 16 patients to elicit their views on the reasons for failure to attend the colonoscopy procedure following a positive stool test. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1253DOI Listing

Inhibitory Effect of Eco-Friendly Naturally Synthesized Silver Nanoparticles from the Leaf Extract of Medicinal Detarium microcarpum Plant on Pancreatic and Cervical Cancer Cells.

Asian Pac J Cancer Prev 2020 May 1;21(5):1247-1252. Epub 2020 May 1.

School of Biological Sciences, Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.

Background: Recently, nanoparticle synthesis by eco-friendly methods has received tremendous attention due to the method advantages and also because of the application of the nanoparticles in cancer research. Therefore, in this study, we synthesized silver nanoparticles from Detarium microcarpum leaf phytochemicals and evaluated its inhibitory effect on pancreatic and cervical cancer cells.

Materials And Methods: Silver nanoparticles (dAgNps) were synthesized by reacting phytochemicals of D. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1247DOI Listing

Exploring Two Protocols of FISH Using Cytocell SYT-SSX Probe on Formalin Fixed Paraffin Embedded Tissue Sections.

Asian Pac J Cancer Prev 2020 May 1;21(5):1241-1245. Epub 2020 May 1.

Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Kelantan, Malaysia.

Background: Chromosomal translocation t(X;18)(p11.2;q11.2) is the cytogenetic hallmark of synovial sarcoma and have been identified as an alternative diagnostic strategy in differentiating synovial sarcoma from other histologic mimics. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1241DOI Listing

Genomic Instability in Peripheral Blood and Buccal Mucosal Cells of Marijuana Smokers: The Impact of Tobacco Smoke.

Asian Pac J Cancer Prev 2020 May 1;21(5):1235-1239. Epub 2020 May 1.

Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Santos, SP, Brazil.

Background: The aim of this study was to evaluate cytotoxic, mutagenic and genotoxic effects on buccal mucosa and peripheral blood cells from marijuana and tobacco smokers.

Methods: For this purpose, a total of 45 volunteers were distributed into four groups: CTRL group (control): individuals who did not smoke marijuana or tobacco (n = 11); Group M: Marijuana smokers (n = 13); Group T: Tobacco smokers (n = 13); Group M + T: Smokers of both marijuana and tobacco (n = 08).

Results: Smokers of both marijuana and tobacco led an increase of micronucleated cells on buccal mucosa when compared to control group. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1235DOI Listing

The Impact of Surgery and Radiotherapy on Health-Related Quality of Life of Individuals with Oral and Oropharyngeal Carcinoma and Short-Term Follow up after Treatment.

Asian Pac J Cancer Prev 2020 May 1;21(5):1227-1234. Epub 2020 May 1.

Oral Oncology Center and Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.

Objective: This study aimed to evaluate the quality of life of patients with oral or oropharyngeal cancer by using specific questionnaires (QLQ-C30 and QLQ-HandN35), varying according to the location of the tumor (oral cavity or oropharynx) and the treatment performed (only surgery or surgery associated with radiotherapy).

Methods: Fifty patients were enrolled in this study and answered the EORTC QLQ-C30 and EORTC HandN35 questionnaires, before (baseline), at 1 week, and 3 months after treatment. Internal consistency reliability was calculated with the Cronbach coefficient. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1227DOI Listing

Association of EGLN2 rs10680577 Polymorphism with the Risk and Clinicopathological Features of Patients with Prostate Cancer.

Asian Pac J Cancer Prev 2020 May 1;21(5):1221-1226. Epub 2020 May 1.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Several studies have evaluated the association between EGLN2 4-bp insertion/deletion (ins/del) polymorphism (rs10680577) and many cancers. However, up to date, no study has inspected the impact of rs10680577 polymorphism on prostate cancer (PCa) risk. This case-control study was achieved on 170 pathologically confirmed PCa patients and 196 cancer free men to inspect whether rs10680577 variant is related to the risk and clinicopathological features of patients with PCa. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1221DOI Listing

The Effect of (E)-1-(4'-aminophenyl)-3-phenylprop-2-en-1-one on MicroRNA-18a, Dicer1, and MMP-9 Expressions against DMBA-Induced Breast Cancer.

Asian Pac J Cancer Prev 2020 May 1;21(5):1213-1219. Epub 2020 May 1.

Department of Histology and Cell Biology,Universitas Gadjah Mada, Yogyakarta, Indonesia.

Background: Most of breast cancer patients are estrogen receptor alpha-positive and have high resistance and side effect of chemotherapeutic drug. Therefore, discovering an effective anticancer agent is needed. This research explored the effect of (E)-1-(4'-aminophenyl)-3-phenylprop-2-en-1-one (APE) on miR-18a, Dicer1, and MMP-9 expressions. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1213DOI Listing

An Asian Body to Tackle Cancers in Asia - The Asian National Cancer Centers Alliance.

Asian Pac J Cancer Prev 2020 May 1;21(5):1207-1212. Epub 2020 May 1.

National Cancer Center, Japan, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

The socioeconomic burden of cancer is growing rapidly in the Asian region, with a concentrated burden on low- and middle- income countries. The residents of this region, representing almost 60% of the global population, demonstrate an eclectic and complex nature, with huge disparities in ethnicity, sociocultural practices among others. The Asian National Cancer Centers Alliance (ANCCA) was established in 2005 by heads of several national cancer centers (NCCs) in the region to address common issues and concerns among Asian countries. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1207DOI Listing

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis.

Asian Pac J Cancer Prev 2020 May 1;21(5):1197-1206. Epub 2020 May 1.

Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Primary studies have shown that the IL-12B rs3212227 and IL-6 rs1800795 polymorphisms are associated with an increased risk of cervical cancer. However, conflicting results warrant a meta-analysis to obtain more precise estimates.

Methods: A comprehensive literate search on PubMed, Web of Science, Scopus, CNKI, and SciELO was performed to collect all eligible studies up to November 10, 2019. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1197DOI Listing

Indocyanine Green Fluorescence Versus Blue Dye or Radioisotope Regarding Detection Rate of Sentinel Lymph Node Biopsy and Nodes Removed in Breast Cancer: A Systematic Review and Meta-Analysis.

Asian Pac J Cancer Prev 2020 May 1;21(5):1187-1195. Epub 2020 May 1.

Division of Head Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Either blue dye (BD) or radioisotope (RI) is mainly used for sentinel lymph node biopsy (SLNB) in breast cancer patients. Unlike the BD, RI has lower false-negative rate of SLNB. However, its lymphoscintigraphy, difficulty in preoperative injection, and undetected sentinel lymph nodes in some cases cause surgeons to rely only on BD. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1187DOI Listing