11,628 results match your criteria Asian Cardiovascular & Thoracic Annals Asian Annals[Journal]


A systematic review of LDLR, PCSK9, and APOB variants in Asia.

Atherosclerosis 2020 May 20;305:50-57. Epub 2020 May 20.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran; Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Aims: Genetic identification is a public health care concern for management of familial hypercholesterolemia (FH) associated cardiovascular morbidity and mortality. This study presents the spectrum and distribution of LDLR, APOB, PCSK9 gene mutations in Asia.

Methods: Databases were searched for English papers from 1950 to 2019. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.05.004DOI Listing

Lean Americans With Nonalcoholic Fatty Liver Disease Have Lower Rates of Cirrhosis and Co-morbid Diseases.

Clin Gastroenterol Hepatol 2020 Jul 3. Epub 2020 Jul 3.

University of Michigan, Ann Arbor, MI. Electronic address:

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is typically associated with obesity. Little is known about the prevalence of cirrhosis in patients with NAFLD and a normal body mass index (BMI).

Methods: We determined prevalence of cirrhosis, cardiovascular disease (CVD), and metabolic abnormalities among participants in all BMI categories in the TARGET-NASH study. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.066DOI Listing

Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review.

Life Sci 2020 Jul 3:118019. Epub 2020 Jul 3.

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien 970, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

Parkinson's disease (PD) is a disease of the human nervous system with an onset, in the sixth and seventh decades of the human life. Chiefly perceived as progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) with the ensued loss of dopamine in the striatum and the presence of Lewy bodies, consisting of α-synuclein agglomeration. In which the neuronal bridge between substantia nigra and striatum plays an advent role in the motor system. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118019DOI Listing

Racial disparities and outcomes of left ventricular assist device implantation as a bridge to heart transplantation.

ESC Heart Fail 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, Division of Cardiac Surgery, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA.

Aims: This study investigated outcomes after continuous flow left ventricular assist device (CF-LVAD) implantation as bridge to heart transplantation (BTT) in advanced heart failure patients stratified by race.

Methods And Results: De-identified data from the United Network for Organ Sharing database was obtained for all patients who had a CF-LVAD as BTT from 2008 to 2018. Patients were stratified into four groups on the basis of ethnicity [Caucasian, African American (AA), Hispanic, and others (Asian, Pacific Islanders, and American Indian)]. Read More

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http://dx.doi.org/10.1002/ehf2.12866DOI Listing

Gender differences in sarcopenia and frailty in community-dwelling Korean older adults with diabetes: the Korean Frailty and Aging Cohort Study.

J Diabetes Investig 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Aims/introduction: We aimed to examine the prevalence of sarcopenia and frailty in Korean older adults with diabetes compared with subjects without diabetes.

Materials And Methods: We analyzed the data of 2,403 participants aged 70-84 years enrolled in the Korean Frailty and Aging Cohort Study. Sarcopenia was defined using the Asian Working Group for Sarcopenia (AWGS) and the Foundation for the National Institutes of Health (FNIH). Read More

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http://dx.doi.org/10.1111/jdi.13348DOI Listing

Asia-Pacific Consensus Statement on the Management of Peripheral Artery Disease: A Report from the Asian Pacific Society of Atherosclerosis and Vascular Disease Asia-Pacific Peripheral Artery Disease Consensus Statement Project Committee.

J Atheroscler Thromb 2020 Jul 4. Epub 2020 Jul 4.

Department of Clinical Epidemiology, University of the Philippines College of Medicine.

Background: Peripheral artery disease (PAD) is the most underdiagnosed, underestimated and undertreated of the atherosclerotic vascular diseases despite its poor prognosis. There may be racial or contextual differences in the Asia-Pacific region as to epidemiology, availability of diagnostic and therapeutic modalities, and even patient treatment response. The Asian Pacific Society of Atherosclerosis and Vascular Diseases (APSAVD) thus coordinated the development of an Asia-Pacific Consensus Statement (APCS) on the Management of PAD. Read More

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http://dx.doi.org/10.5551/jat.53660DOI Listing

High Bleeding Risk and Clinical Outcomes in East Asian Patients Undergoing Percutaneous Coronary Intervention: the PENDULUM Registry.

EuroIntervention 2020 Jul 7. Epub 2020 Jul 7.

Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.

Aims: We evaluated the validity of the Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria for East Asian patients undergoing contemporary percutaneous coronary intervention (PCI) from the PENDULUM registry.

Methods And Results: This post hoc analysis included 6,267 Japanese patients undergoing PCI between December 2015 and June 2017 enrolled in PENDULUM. The primary endpoint was incidence of major bleeding at 12 months post-index PCI. Read More

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http://dx.doi.org/10.4244/EIJ-D-20-00345DOI Listing

Epidemiology of Male Sexual Dysfunction in Asian and European Regions: A Systematic Review.

Am J Mens Health 2020 Jul-Aug;14(4):1557988320937200

Department of Family Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Male sexual dysfunctions (MSDs) often remain undiagnosed and untreated in Asia compared to Europe due to conservative cultural and religious beliefs, socioeconomic conditions, and lack of awareness. There is a tendency for the use of traditional medicines and noncompliance with and reduced access to modern healthcare. The present systematic review compared the incidence and factors of MSD in European and Asian populations. Read More

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http://dx.doi.org/10.1177/1557988320937200DOI Listing

Prevalence of abdominal obesity in non-obese adolescents: a North Indian adolescent study.

J Pediatr Endocrinol Metab 2020 Jul 4. Epub 2020 Jul 4.

Department of Endocrinology, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.

Context Childhood obesity is defined based on body mass index (BMI) criteria. Asian adults have more abdominal adiposity as compared to Western people for an equivalent BMI. Similarly, children who are non-obese/overweight by BMI criteria may have abdominal obesity. Read More

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http://dx.doi.org/10.1515/jpem-2019-0026DOI Listing

Impact of hypertension stratified by diabetes on the lifetime risk of cardiovascular disease mortality in Japan: a pooled analysis of data from the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan study.

Hypertens Res 2020 Jul 3. Epub 2020 Jul 3.

Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan.

Lifetime risk is an informative estimate to motivate people to change lifestyle behaviors, especially from a younger age, in public health education. The impact of the combination of hypertension and diabetes on the lifetime risk of cardiovascular mortality has not been investigated in Asian populations. A pooled analysis of individual data from nine cohorts was performed. Read More

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http://dx.doi.org/10.1038/s41440-020-0502-5DOI Listing

'I don't do it for myself, I do it for them'. A grounded theory study of South Asians' experiences of making lifestyle change after myocardial infarction.

J Clin Nurs 2020 Jul 3. Epub 2020 Jul 3.

School of Human and Health Sciences, University of Huddersfield, Huddersfield, UK.

Aims And Objectives: To explore South Asians' experience of choosing and prioritising lifestyle changes during their recovery from first myocardial infarction.

Background: Coronary heart disease continues to be a leading cause of premature death globally. South Asians' suffer increased risk of coronary heart disease and have poorer outcomes following myocardial infarction compared to other ethnic groups. Read More

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http://dx.doi.org/10.1111/jocn.15395DOI Listing

Coronary-coronary bypass grafting: artery or vein?

Asian Cardiovasc Thorac Ann 2020 Jul 2:218492320941689. Epub 2020 Jul 2.

Center for Cardiovascular Surgery, Penza, Russia.

Background: The method of coronary-coronary bypass grafting was described in 1987 but has not been widely used, and there are only a few studies that report good short-term and mid-term results as well as some individual cases of long-term follow-up. In our medical institution, we carried out an analysis of the long-term results of coronary-coronary bypass grafting, which are presented in this study.

Methods: This was a retrospective single-center study on 95 patients who underwent coronary-coronary bypass grafting as a supplement to the standard coronary bypass grafting procedure. Read More

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http://dx.doi.org/10.1177/0218492320941689DOI Listing

Tacrolimus trough levels higher than 6 ng/mL might not be required after a year in stable kidney transplant recipients.

PLoS One 2020 2;15(7):e0235418. Epub 2020 Jul 2.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Background: Little is known regarding optimal tacrolimus (TAC) trough levels after 1 year post-transplant in stable kidney transplant recipients (KTRs) who have not experienced renal or cardiovascular outcomes. This study aimed to investigate the effect of 1-year post-transplant TAC trough levels on long-term renal and cardiovascular outcomes and opportunistic infections in stable KTRs.

Methods: KTRs receiving TAC with mycophenolate-based immunosuppression who did not experience renal or cardiovascular outcomes within 1 year post-transplant were enrolled from a multicenter observational cohort study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235418PLOS

A comparison of cardiovascular risk scores in native and migrant South Asian populations.

SSM Popul Health 2020 Aug 11;11:100594. Epub 2020 May 11.

Freeman Hospital, Newcastle-upon-Tyne, UK.

Background: South Asians have increased cardiovascular risk burden but little data exists comparing cardiovascular (CV) risk models in migrant and native South Asians. Our retrospective cohort study in patients presenting with first acute myocardial infarction(MI) compares the predictive value of CV risk scores in native and UK migrant South Asians.

Methods: Retrospective cohort study of 80 UK-based patients of South Asian origin admitted with first presentation MI, excluding patients with known coronary artery disease. Read More

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http://dx.doi.org/10.1016/j.ssmph.2020.100594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322355PMC

Remogliflozin Etabonate in the Treatment of Type 2 Diabetes: Design, Development, and Place in Therapy.

Drug Des Devel Ther 2020 24;14:2487-2501. Epub 2020 Jun 24.

Deptartment of Endocrinology, IPGME&R and SSKM Hospital, Kolkata, India.

Type 2 diabetes mellitus (T2DM) is an emerging epidemic in Asian countries, especially in India. With the advent of the SGLT2 inhibitor class of drugs demonstrating benefits beyond glycemic control, viz. weight loss, blood pressure reduction, and cardiovascular and renal protection, the management of T2DM has taken a quantum leap. Read More

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http://dx.doi.org/10.2147/DDDT.S221093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322139PMC

Thoracic cancer surgery during the COVID-19 pandemic: A consensus statement from the Thoracic Domain of the Asian Society for Cardiovascular and Thoracic Surgery.

Asian Cardiovasc Thorac Ann 2020 Jul 1:218492320940162. Epub 2020 Jul 1.

Department of Thoracic Surgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Objectives: Healthcare resources have been mobilized to combat the COVID-19 pandemic of 2020. The Thoracic Domain of the Asian Society for Cardiovascular and Thoracic Surgery reports a consensus statement on the provision of thoracic cancer surgery during this pandemic.

Methods: A Thoracic Experts Panel was convened by the Society. Read More

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http://dx.doi.org/10.1177/0218492320940162DOI Listing

Successful treatment of delayed esophageal perforation caused by air-blast trauma.

Asian J Surg 2020 Jun 27. Epub 2020 Jun 27.

Department of Internal Medicine, Pusan National University Hospital, Medical Research Institution, Busan, Republic of Korea.

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http://dx.doi.org/10.1016/j.asjsur.2020.06.002DOI Listing

Ethnic differences in association of outcomes with trimethylamine N-oxide in acute heart failure patients.

ESC Heart Fail 2020 Jun 29. Epub 2020 Jun 29.

Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.

Aims: The aim of this study was to investigate whether ethnicity influences the associations between trimethylamine N-oxide (TMAO) levels and heart failure (HF) outcomes.

Methods And Results: Trimethylamine N-oxide levels were measured in two cohorts with acute HF at two sites. The UK Leicester cohort consisted mainly of Caucasian (n = 842, 77%) and South Asian (n = 129, 12%) patients, whereas patients in the Japanese cohort (n = 116, 11%) were all Japanese. Read More

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http://dx.doi.org/10.1002/ehf2.12777DOI Listing

The role of ginsenoside Rb1 in bone homeostasis.

Curr Stem Cell Res Ther 2020 Jun 28. Epub 2020 Jun 28.

Department of spine, Honghui-hospital, Xi'an Jiaotong university, school of medicine, Xi'an, China; 2Yan'an University, Yan' an. China.

Panax ginseng,as a well-known medical plant with economic value,has a long history of use for treating various diseases in Asian. Accumulating clinical and experimental evidences suggest that ginsenoside Rb1,which is the major bioactive components of the plant, have a variety of biological effects on treating aging related diseases such as: cardiovascular disease (CVD), central nervous system disease (CNSD), and osteoporosis (OP). Recently, considerable attentions have been focused on ginsenoside Rb1 as an anti-osteoporosis agent. Read More

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http://dx.doi.org/10.2174/1574888X15666200628141743DOI Listing

Meta-Analysis of the Association Between the rs228570 Vitamin D Receptor Gene Polymorphism and Arterial Hypertension Risk.

Adv Nutr 2020 Jun 29. Epub 2020 Jun 29.

Post-Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.

The association between FokI polymorphism in the vitamin D receptor (VDR) gene and susceptibility to arterial hypertension (HT) is controversial. Thus, we evaluated the relation between FokI and HT according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using MEDLINE® (Medical Literature Analysis and Retrieval System Online)/PubMed, Scopus, and Cochrane Library CENTRAL databases. Data from case-control studies, including the number of participants, age, 25-hydroxyvitamin D concentrations, systolic and diastolic blood pressure values, FokI allele, and genotype frequency were extracted by 2 independent authors and OR was calculated with the 95% CI to assess the strength of the association between the FokI variant and odds of HT. Read More

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http://dx.doi.org/10.1093/advances/nmaa076DOI Listing

Prevalence of sudden arrhythmic death syndrome-related genetic mutations in an Asian cohort of whole genome sequence.

Europace 2020 Jun 28. Epub 2020 Jun 28.

Division of Cardiology, Department of Internal Medicine and Cardiovascular center, National Taiwan University College of Medicine and Hospital, No. 7, Chung-Shan South Road, Taipei 100, Taiwan.

Aims: Recently, the spectrum of background mutation in the genes implicated in sudden arrhythmic death syndrome (SADS), has been elucidated in the Caucasian populations. However, this information is largely unknown in the Asian populations.

Methods And Results: We assessed the background rare variants (minor allele frequency < 0. Read More

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http://dx.doi.org/10.1093/europace/euaa092DOI Listing

Effects of bariatric surgery on kidney diseases, cardiovascular diseases, mortality and severe hypoglycaemia among patients with Type 2 diabetes mellitus.

Nephrol Dial Transplant 2020 Jun 27. Epub 2020 Jun 27.

Department of Family Medicine and Primary Care, The University of Hong Kong, Hong Kong SAR, China.

Background: Bariatric surgery has been widely indicated for the management of obesity and related comorbidities. However, there are uncertainties pertaining to the risks of post-bariatric severe hypoglycaemia (SH), cardiovascular diseases (CVDs), end-stage kidney diseases (ESKDs) and all-cause mortality in obese patients with Type 2 diabetes mellitus (T2DM), especially among Asian populations.

Methods: A retrospective population-based cohort of 1702 obese T2DM patients who were free of CVD and ESKD were assembled based on the 2006-17 Hospital Authority database. Read More

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http://dx.doi.org/10.1093/ndt/gfaa075DOI Listing

The impact of the risk of COVID-19 on Black, Asian and Minority Ethnic (BAME) members of the UK dental profession.

Br Dent J 2020 Jun;228(12):919-922

General Dental Practitioner, Honour Health, Newcastle, Honorary Clinical Lecturer, Newcastle Dental School, UK.

There is growing evidence that Black, Asian and Minority Ethnic (BAME) groups in the UK are at increased risk of death from coronavirus (COVID-19), with Black Afro-Caribbean, Indian, Pakistani and Bangladeshi populations being particularly at risk. Although the reasons are unclear, it is likely to be a combination of cultural and socioeconomic, as well as the higher prevalence of co-morbidities such as high blood pressure, cardiovascular disease, raised body mass index (BMI) and type 2 diabetes in these populations. The NHS is advising that frontline staff of BAME origin should be risk-assessed regarding their safety in working in clinical areas which are at risk of COVID-19. Read More

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http://dx.doi.org/10.1038/s41415-020-1781-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319204PMC

Genetic Predisposition in Metabolic-Dysfunction-Associated Fatty Liver Disease and Cardiovascular Outcomes - Systematic Review.

Eur J Clin Invest 2020 Jun 26:e13331. Epub 2020 Jun 26.

Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background: Despite the demonstrated increased cardiovascular (CV) risk associated with metabolic-dysfunction-associated fatty liver disease (MAFLD), genetic variants predisposing to MAFLD were not constantly associated with CV events. Recently, rs641738C>T near membrane bound O-acyltransferase domain containing 7 (MBOAT7) has been studied in MAFLD and CV outcomes. Therefore, we aimed to evaluate the association between rs641738C>T in the presence and severity of hepatic steatosis, fibrosis, biochemical markers and progression to hepatocellular carcinoma (HCC), in addition to CV outcomes in MAFLD. Read More

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http://dx.doi.org/10.1111/eci.13331DOI Listing

Association between Surrounding Greenness and Mortality: An Ecological Study in Taiwan.

Int J Environ Res Public Health 2020 Jun 23;17(12). Epub 2020 Jun 23.

Institute of Environmental and Occupational Health Sciences, National Yang-Ming University, Taipei 112, Taiwan.

Exposure to surrounding greenness is associated with reduced mortality in Caucasian populations. Little is known however about the relationship between green vegetation and the risk of death in Asian populations. Therefore, we opted to evaluate the association of greenness with mortality in Taiwan. Read More

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http://dx.doi.org/10.3390/ijerph17124525DOI Listing

Antithrombotic Strategy for Patients with Acute Coronary Syndrome: A Perspective from East Asia.

J Clin Med 2020 Jun 23;9(6). Epub 2020 Jun 23.

Department of Cardiology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention has become the standard of care, particularly in patients with acute coronary syndrome (ACS). Current clinical guidelines recommend novel P2Y12 inhibitors (e.g. Read More

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http://dx.doi.org/10.3390/jcm9061963DOI Listing

Effects of combined renin-angiotensin-aldosterone system inhibitor and beta-blocker treatment on outcomes in heart failure with reduced ejection fraction: insights from BIOSTAT-CHF and ASIAN-HF registries.

Eur J Heart Fail 2020 Jun 25. Epub 2020 Jun 25.

National Heart Centre Singapore, Singapore, Singapore.

Background: Angiotensin-converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARB) and β-blockers are guideline-recommended first-line therapies in heart failure (HF) with reduced ejection fraction (HFrEF). Previous studies showed that individual drug classes were under-dosed in many parts of Europe and Asia. In this study, we investigated the association of combined up-titration of ACEi/ARBs and β-blockers with all-cause mortality and its combination with hospitalization for HF. Read More

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http://dx.doi.org/10.1002/ejhf.1869DOI Listing

"We understand our community": implementation of the Healthy Eating Healthy Aging program among community-based organizations.

Transl Behav Med 2020 Jun 25. Epub 2020 Jun 25.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Cardiovascular disease is the second leading cause of death in the USA among Asian Americans and Pacific Islanders (AAPIs) over the age of 65. Healthy Eating Healthy Aging (HEHA), an evidence-based heart health program, can provide culturally appropriate nutrition education to decrease the risk of cardiovascular disease. Community-based organizations (CBOs) are optimal settings to implement community-based programs. Read More

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http://dx.doi.org/10.1093/tbm/ibaa049DOI Listing

Six-minute walking distance in healthy Chinese people older than 60 years.

BMC Pulm Med 2020 Jun 22;20(1):177. Epub 2020 Jun 22.

Department of General Practice, Zhejiang Hospital, Hangzhou, Zhe Jiang, China.

Background: The six-minute walking test (6MWT) is a tool that plays a key role in evaluating the functional exercise capacity, prognosis and evaluation of treatment response of patients with various cardiopulmonary diseases. However, standard reference equations are currently unavailable for the six-minute walking distance (6MWD) for people aged 60-85 years in China. The purpose of this study was to 1) measure the 6MWD of healthy Chinese people aged 60-85 years, 2) establish reference equations for predicting the 6MWD, and 3) compare our reference equations with equations reported in previously published studies. Read More

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http://dx.doi.org/10.1186/s12890-020-01211-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310198PMC

Clinical study of stent forming for symptomatic internal carotid artery stenosis.

Medicine (Baltimore) 2020 Jun;99(25):e20637

The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Stroke is one of the diseases that seriously threaten the survival and health of human beings. In Europe and the United States, stroke is the second leading cause of death after heart disease and tumors. Stroke is also one of the fatal diseases in Asian countries. Read More

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http://dx.doi.org/10.1097/MD.0000000000020637DOI Listing

The effect of antiplatelet drug on coronary endothelial and microvascular function: comparison with ticagrelor and clopidogrel.

Korean J Intern Med 2020 Jun 23. Epub 2020 Jun 23.

Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea.

Background/aims: Coronary endothelial and microvascular function play important roles in cardiovascular disease. We aimed to evaluate the effect of ticagrelor on coronary artery function and tested the antiplatelet effect of low dose ticagrelor in East-Asian patients.

Methods: Sixty-one consecutive patients with non-significant coronary disease were included in the study. Read More

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http://dx.doi.org/10.3904/kjim.2019.293DOI Listing

Pioglitazone for primary stroke prevention in Asian patients with type 2 diabetes and cardiovascular risk factors: a retrospective study.

Cardiovasc Diabetol 2020 Jun 20;19(1):94. Epub 2020 Jun 20.

Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.

Background: Studies assessing the efficacy of pioglitazone solely for primary stroke prevention in Asian patients with type 2 diabetes mellitus (DM) and present multiple cardiovascular (CV) risk factors are rare. Thus, we aimed to assess the effect of pioglitazone on primary stroke prevention in Asian patients with type 2 DM without established CV diseases but with risk factors for CV diseases.

Methods: Between 2000 and 2012, we enrolled patients aged ≥ 18 years, who were newly diagnosed with type 2 diabetes and had at least one of the following CV risk factors: hypertension and hyperlipidemia. Read More

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http://dx.doi.org/10.1186/s12933-020-01056-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306145PMC

The burden of acute conjunctivitis attributable to ambient particulate matter pollution in Singapore and its exacerbation during South-East Asian haze episodes.

Sci Total Environ 2020 Jun 11;740:140129. Epub 2020 Jun 11.

Eye & Retina Surgeons, 38 Irrawaddy Road #07-63, Mount Elizabeth Novena Specialist Centre, Singapore 329563, Singapore; Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore.

Introduction: Urban air quality in South-East Asia is influenced by local and transboundary sources of air pollutants. Research studies have well characterized the short-term effects of air pollution on cardiovascular and respiratory health but less so on ocular health. We investigated the relationship between air pollution and acute conjunctivitis in Singapore, a tropical city-state located in South-East Asia. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140129DOI Listing

Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation.

Aging Cell 2020 Jun 19. Epub 2020 Jun 19.

Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, China.

The COVID-19 coronavirus is now spreading worldwide. Its pathogen, SARS-CoV-2, has been shown to use angiotensin-converting enzyme 2 (ACE2) as its host cell receptor, same as the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. Epidemiology studies found males although only slightly more likely to be infected than females account for the majority of the severely ill and fatality, which also bias for people older than 60 years or with metabolic and cardiovascular diseases. Read More

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http://dx.doi.org/10.1111/acel.13168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323071PMC

The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men.

Diabetes Obes Metab 2020 Jun 18. Epub 2020 Jun 18.

Department of Medicine, Division of Endocrinology.

Aims: To compare the effects of cold exposure and the β3-adrenergic receptor agonist mirabegron on plasma lipids, energy expenditure and brown adipose tissue (BAT) activity in South Asians versus Europids.

Material And Methods: Ten lean Dutch South Asian (age 18-30 years; BMI 18-25 kg/m ) and ten age- and BMI-matched Europid men participated in a randomized, double-blinded, cross-over study consisting of three interventions; short-term (approx. 2 hours) cold exposure, mirabegron (200 mg one dose p. Read More

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http://dx.doi.org/10.1111/dom.14120DOI Listing

Fruit Extract of Pithecellobium dulce (FPD) ameliorates carrageenan-induced acute inflammatory responses via regulating pro-inflammatory mediators.

J Food Biochem 2020 Jun 17:e13329. Epub 2020 Jun 17.

Laboratory of Immunopharmacology and Experimental Therapeutics, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Medical College Campus, Thiruvananthapuram, India.

Unravelling the precise mechanisms underlying the anti-inflammatory action of fruit extract of Pithecellobium dulce (FPD) is quite complex. Hence the prime approach of this particular study is to unveil intriguing insights to its possible anti-inflammatory mechanisms. Anti-inflammatory effects of FPD were determined against experimentally induced acute and chronic inflammation in mice paw edema models. Read More

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http://dx.doi.org/10.1111/jfbc.13329DOI Listing
June 2020
0.741 Impact Factor

Cost-Effectiveness Analysis of Linagliptin in Japan Based on Results from the Asian Subpopulation in the CARMELINA Trial.

Diabetes Ther 2020 Jun 17. Epub 2020 Jun 17.

Nippon Boehringer Ingelheim Co., Ltd., Tokyo, Japan.

Introduction: We evaluated the cost-effectiveness of linagliptin in Japan by estimating the lifetime outcome based on clinical event rates from the Asian subpopulation of the CARMELINA trial. In CARMELINA, linagliptin added to standard of care (SoC) versus SoC demonstrated noninferiority with regard to risk of composite cardiovascular (CV) outcome in patients with type 2 diabetes at high risk of CV and kidney events. Issues resulting from conducting a cost-effectiveness analysis using data from a clinical noninferiority study were also investigated. Read More

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http://dx.doi.org/10.1007/s13300-020-00852-8DOI Listing

Mitral prosthetic size predictor in minimally invasive mitral valve replacement.

J Cardiothorac Surg 2020 Jun 18;15(1):147. Epub 2020 Jun 18.

Cardiovascular surgery department, University Medical Center, University of Medicine and Pharmacy at Ho Chi Minh city, 215 Hong Bang St - District 05, Ho Chi Minh City, Vietnam.

Background: Minimally invasive mitral valve replacement has become popular across the world. However, annular rupture and patient - prosthetic mismatch (PPM) are still problematic, particularly in the Asian population. To avoid this, a predictor model could be beneficial. Read More

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http://dx.doi.org/10.1186/s13019-020-01197-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301474PMC

Is Conscientiousness Always Associated With Better Health? A U.S.-Japan Cross-Cultural Examination of Biological Health Risk.

Pers Soc Psychol Bull 2020 Jun 18:146167220929824. Epub 2020 Jun 18.

The University of Texas at Dallas, Richardson, USA.

In Western societies, conscientiousness is associated with better health. Here, we tested whether this pattern would extend to East Asian, collectivistic societies. In these societies, social obligation motivated by conscientiousness could be excessive and thus health-impairing. Read More

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http://dx.doi.org/10.1177/0146167220929824DOI Listing

Thoracic endovascular aortic repair for an ascending aortic pseudoaneurysm.

Asian Cardiovasc Thorac Ann 2020 Jun 19:218492320937142. Epub 2020 Jun 19.

Department of Cardiovascular Surgery, Kanazawa University, Kanazawa, Japan.

An 80-year-old woman underwent aortic valve replacement and ascending aortic replacement. Two years later, computed tomography revealed a pseudoaneurysm of the ascending aorta replaced with a prosthesis. The pseudoaneurysm arose from the stump of a side branch of the prosthesis. Read More

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http://dx.doi.org/10.1177/0218492320937142DOI Listing

Corridor technique for coronary arteries from a single arterial sinus.

Asian Cardiovasc Thorac Ann 2020 Jun 19:218492320937506. Epub 2020 Jun 19.

Department of Pediatrics, Ehime University, Ehime, Japan.

The introduction of the arterial switch operation has improved the surgical outcome of transposition of the great arteries. However, coronary anomalies such as intramural coronary arteries, single coronary artery, or coronary arteries originating from a single arterial sinus have been reported as independent risk factors for early mortality and late morbidity after an arterial switch operation. We performed an arterial switch operation using a unique technique for translocation of the coronary arteries originating from a single left-side arterial sinus, to prevent coronary artery distortion and subsequent coronary malperfusion. Read More

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http://dx.doi.org/10.1177/0218492320937506DOI Listing

South Asian-Specific Intronic Deletion and Its Role in Cardiomyopathies and Heart Failure.

Circ Genom Precis Med 2020 Jun 16;13(3):e002986. Epub 2020 Jun 16.

Division of Cardiovascular Health and Disease, Department of Internal Medicine, Heart, Lung and Vascular Institute, College of Medicine, University of Cincinnati, OH. Center for Genetic Medicine, Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1161/CIRCGEN.120.002986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301913PMC

Hybrid surgical procedure for treatment of persistent sciatic artery with limb ischemia: A case report.

Asian J Surg 2020 Jun 12. Epub 2020 Jun 12.

Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

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http://dx.doi.org/10.1016/j.asjsur.2020.05.020DOI Listing

Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting.

Indian Heart J 2020 Mar - Apr;72(2):119-122. Epub 2020 Apr 6.

Boehringer Ingelheim, Mumbai, India.

Background: The cardiovascular (CV) risk of patients with Type 2 diabetes (T2D) of Indo-Asian descent has never been objectively assessed, although it is documented that they have a higher prevalence of CV disease (CVD).

Aims: To identify groups of Indian patients with asymptomatic T2D who are at high risk of CVD as per the QRISK calculator.

Method: After an adequate power calculation, a nation-wide study of patients with asymptomatic T2D was conducted. Read More

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http://dx.doi.org/10.1016/j.ihj.2020.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296234PMC

JCL roundtable: Healthy ethnic diets.

J Clin Lipidol 2020 May - Jun;14(3):274-281

Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA. Electronic address:

Epidemiology has long suggested that diet plays a major role in determining risk for atherosclerotic cardiovascular disease. A small number of important randomized controlled trials support this contention. We have to recognize that dietary patterns also constitute a large part of ethnic identity. Read More

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http://dx.doi.org/10.1016/j.jacl.2020.05.006DOI Listing

Community Pharmacy-Based eGFR Screening for Early Detection of CKD in High Risk Patients.

Can J Kidney Health Dis 2020 18;7:2054358120922617. Epub 2020 May 18.

Department of Pharmacy, Sint Maartenskliniek. Nijmegen, The Netherlands.

Background: Chronic kidney disease (CKD) is a condition presenting with long-term slow progression of structural and/or functional damage to the kidneys. Early detection is key to preventing complications and improving outcomes. Point-of-care estimated glomerular filtration rate (eGFR) screening technology allows for detection of abnormal kidney function in the community pharmacy setting. Read More

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http://dx.doi.org/10.1177/2054358120922617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235648PMC

Sex difference in the prognostic role of body composition parameters in Taiwanese patients undergoing transcatheter aortic valve implantation.

BMC Cardiovasc Disord 2020 Jun 10;20(1):283. Epub 2020 Jun 10.

Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Background: Evidence on association between body composition and outcomes of transcatheter aortic valve implantation (TAVI) is limited for Asian patients. This study investigated the prognostic role of body composition parameters in Taiwanese patients undergoing TAVI.

Materials And Methods: Data of consecutive patients undergoing TAVI for severe aortic stenosis between May 1, 2010 and August 31, 2019 were prospectively collected in this observational study. Read More

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http://dx.doi.org/10.1186/s12872-020-01569-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288684PMC

Loading doses of ticagrelor versus clopidogrel in preventing periprocedural myocardial infarction in Asian patients with acute coronary syndrome.

Perfusion 2020 Jun 10:267659120927857. Epub 2020 Jun 10.

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Background: Periprocedural myocardial infarction is a common complication following percutaneous coronary intervention. The present study was conducted with an aim to compare the safety and efficacy of loading doses of ticagrelor versus clopidogrel in preventing periprocedural myocardial infarction in Asian patients with acute coronary syndrome undergoing elective percutaneous coronary intervention.

Methods: A total of 114 patients with acute coronary syndrome undergoing elective percutaneous coronary intervention were assigned to clopidogrel group (n = 57, the loading and maintenance doses were 300 and 75 mg qd for clopidogrel, and 300 and 100 mg qd for aspirin), or ticagrelor group (n = 57, the loading and maintenance doses were 180 and 90 mg bid for ticagrelor, and 300 and 100 mg qd for aspirin). Read More

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http://dx.doi.org/10.1177/0267659120927857DOI Listing

Type 1/type 2 inflammatory cytokines correlate with olfactory function in patients with chronic rhinosinusitis.

Am J Otolaryngol 2020 Jun 1;41(5):102587. Epub 2020 Jun 1.

Department of Otolaryngology-Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Chaoyang District, Beijing 100029, China. Electronic address:

Background: Olfactory dysfunction secondary to chronic rhinosinusitis (CRS) has been highly associated with impaired quality of life. Asian CRS patients showed a distinct inflammatory profile, with less type 2 endotype compared with European and North American. This study aimed to explore the pattern of the inflammatory cytokines in CRS patients from China and their association with olfactory function. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102587DOI Listing