Search Our Scientific Publications & Authors

Mol Cell Biochem 2019 Apr 20. Epub 2019 Apr 20.

Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, ICMR-Centre for Advanced Research on Diabetes, Gopalapuram, Chennai, 600086, India.

There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance (n = 30 each). Read More

JAMA Netw Open 2019 Apr 5;2(4):e192696. Epub 2019 Apr 5.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: Asia is home to the largest diabetic populations in the world. However, limited studies have quantified the association of diabetes with all-cause and cause-specific mortality in Asian populations.

Objectives: To evaluate the association of diabetes with all-cause and cause-specific mortality in Asia and to investigate potential effect modifications of the diabetes-mortality associations by participants' age, sex, education level, body mass index, and smoking status. Read More

J Pak Med Assoc 2019 Apr;69(4):555-563

National Institute of Cardiovascular Diseases Karachi, Pakistan.

Sodium-glucose co-transporter type 2 inhibitors (SGLT 2- i)are increasingly being used in the management of type 2 diabetes mellitus (T2DM). With the novel insulinindependent glycosuric action, these agents help to attain glycaemic goals by lowering HbA1c and fasting blood glucose. In addition, these agents improve metabolic control in diabetes and ameliorate comorbidities like obesity and hyper tension. Read More

Indian Heart J 2019 Jan - Feb;71(1):25-31. Epub 2019 Jan 3.

Ruby Hospital, Pune, India.

Background: Acute coronary syndrome (ACS) is associated with emergency hospitalizations, and there are limited real-world data on clinical outcomes in post-ACS Asian patients. This article presents data on the Indian subgroup from the Long-term Follow-up of Antithrombotic Management Patterns in Acute Coronary Syndrome Patients in Asia (EPICOR-Asia) study.

Methods: EPICOR included patients with ACS [ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), or unstable angina (UA)]. Read More

Indian Heart J 2019 Jan - Feb;71(1):15-24. Epub 2019 Jan 25.

University Hospital of State Medical University of Semey, Department of Endovascular Surgery, Semey, Kazakhstan.

Objective: We aimed to assess the efficacy and safety of ticagrelor compared to clopidogrel in Asian patients with acute coronary syndrome (ACS) in real-world practice.

Methods: PubMed, Web of Science and Scopus databases were searched systematically to obtain relevant Asian observational studies.

Results: The meta-analysis included six studies with 27959 participants. Read More

PLoS One 2019 18;14(4):e0215534. Epub 2019 Apr 18.

Department of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, Maryland, United States of America.

This study evaluated the contributions of psychological status and cardiovascular responsiveness to racial/ethnic differences in experimental pain sensitivity. The baseline measures of 3,159 healthy individuals-non-Hispanic white (NHW): 1,637, African-American (AA): 1,012, Asian: 299, and Hispanic: 211-from the OPPERA prospective cohort study were used. Cardiovascular responsiveness measures and psychological status were included in structural equation modeling based mediation analyses. Read More

Open Heart 2019 27;6(1):e000841. Epub 2019 Feb 27.

Cardiology Unit, Universidad de Murcia, Murcia, Spain.

Objectives:  This novel, pilot study aimed to assess the estimated prevalence of high on-treatment platelet reactivity (HPR) in Trinidad and Tobago.

Methods: Patients (n=40) who were awaiting elective percutaneous coronary intervention on maintenance dual antiplatelet therapy (DAPT) with aspirin 81 mg daily and clopidogrel 75 mg or loaded at least 48 hours prior were recruited. Platelet reactivity with the VerifyNow P2Y12 assay (Accriva Diagnostics, San Diego, California, USA) was assessed prior to cardiac catheterisation. Read More

Appl Clin Inform 2019 Mar 17;10(2):261-268. Epub 2019 Apr 17.

Department of Nursing & Emergency Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Background:  Heart failure is one of the serious cardiovascular diseases, which poses a global pandemic and places a heavy burden on health care systems worldwide. The incidence of this disease in Iran is higher than in other Asian countries. To reduce patients' complications, readmission rates, and health care expenditures, it is necessary to design interventions, which are culturally appropriate and based on community needs. Read More

PLoS One 2019 11;14(4):e0213997. Epub 2019 Apr 11.

Department of Anaesthesiology, Singapore General Hospital, Academia, Level 5, Singapore.

Introduction: Genetic polymorphisms are important in explaining the wide interpatient variability that exists in the development of acute kidney injury (AKI) post cardiac surgery. We hypothesised that polymorphisms in 4 candidate genes, namely angiotensin-converting enzyme (ACE), apolipoprotein-E (ApoE), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α) are associated with AKI.

Methods: 870 patients who underwent cardiac surgery in Singapore were analysed. Read More

J Clin Pharmacol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan.

This large-scale case-control study in Taiwan elucidated the potential connection between fibrate use and liver cancer by using the Longitudinal Health Insurance Database 2005 with a propensity-score-matching design. In total, 4173 patients diagnosed as having liver cancer were included as cases, and 4173 propensity-score-matched patients without liver cancer were identified as controls. The association between previous fibrate use and liver cancer occurrence was demonstrated using conditional logistic regression. Read More

J Clin Pharm Ther 2019 Apr 8. Epub 2019 Apr 8.

Department of Medicine, University of Florida, Jacksonville, Florida.

What Is Known And Objective: Race and gender disparities in the context of appropriate treatment with lipid-lowering therapies do exist. The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines outlined four groups, three for primary prevention and one for secondary prevention, whom would benefit from statin therapy to target atherosclerotic cardiovascular disease (ASCVD). The application of these recommendations in Filipino women living in the United States is unknown; however, this population is known to have elevated cardiovascular risk. Read More

Clin Genet 2019 Apr 8. Epub 2019 Apr 8.

Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, China.

Whether the presence of SCN5A mutation is a predictor of BrS risk remains controversial, and patient selection bias may have weakened previous findings. Therefore, we performed this study to clarify the clinical characteristics and outcomes of BrS probands with SCN5A mutations. We systematically retrieved eligible studies published through October 2018. Read More

Int J Stroke 2019 Apr 8:1747493019841246. Epub 2019 Apr 8.

6 The George Institute for Global Health, Faculty of Medicine, University of New South Wales, NSW, Australia.

Background: Randomized controlled trials provide high-level evidence, but the necessity to include selected patients may limit the generalisability of their results.

Methods: Comparisons were made of baseline and outcome data between patients with acute ischemic stroke (AIS) recruited into the alteplase-dose arm of the international, multi-center, Enhanced Control of Hypertension and Thrombolysis Stroke study (ENCHANTED) in the United Kingdom (UK), and alteplase-treated AIS patients registered in the UK Sentinel Stroke National Audit Programme (SSNAP) registry, over the study period June 2012 to October 2015.

Results: There were 770 AIS patients (41. Read More

Int J Environ Res Public Health 2019 Apr 6;16(7). Epub 2019 Apr 6.

Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-0075, Japan.

This cross-sectional study investigated the association between osteoporosis, grip strength, and skeletal muscle mass in community-dwelling older women. Data obtained from 265 older women who participated in a community-based health check survey (Tarumizu Study) were analyzed. Face-to-face interviews with participants revealed their history of osteoporosis. Read More

J Transcult Nurs 2019 Apr 8:1043659619839114. Epub 2019 Apr 8.

2 The University of Texas Health Science Center at San Antonio School of Nursing, San Antonio, TX, USA.

Introduction: The risk for cardiovascular disease (CVD) is higher in South Asians (SAs) than in other ethnic groups. The purpose of this review is to explore SAs' health beliefs regarding CVD risk and risk reduction behaviors including physical activity and healthy diet.

Methodology: An integrative review was conducted to examine the peer-reviewed literature published before May 2017. Read More

J Microbiol Biotechnol 2019 Mar 20. Epub 2019 Mar 20.

Department of Food Science and Biotechnology, College of Life Science, CHA University, Geyonggi-do, Republic of Korea.

Pueraria montana var. lobata is a bioactive substance, in possession of a variety of beneficial health effects, which has long been extensively used as a traditional medication for the treatment of fever, acute dysentery, diabetes, and cardiovascular diseases in North-East Asian countries. The purpose of this study was to evaluate the cytoprotective activity of Pueraria montana var. Read More

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e005600

Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia (A.S.N., Z.G., E.J.D., S.A.M.K., T.K., S.A., J.G., P.W.G.).

Background: Beginning in 2012, direct oral anticoagulants (DOACs) were approved for treatment and prevention of venous thromboembolism. Prior investigations have demonstrated slow rates of adoption of novel therapeutics for black patients. We assessed the association of racial/ethnic and socioeconomic factors with DOAC use among commercially insured venous thromboembolism patients. Read More

Asian Cardiovasc Thorac Ann 2019 Apr 4:218492319841512. Epub 2019 Apr 4.

2 Department of Surgery, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

Background: The Cox maze procedure is the gold-standard concomitant surgical procedure to restore sinus rhythm in rheumatic mitral valve disease with atrial fibrillation. Left atrial reduction surgery was found to be beneficial for rhythm conversion, but no study has investigated its efficacy compared to the Cox maze procedure for atrial contractility restoration. We aimed to compare the early success rate of left atrial contractility restoration with the Cox maze procedure and left atrial reduction in rheumatic subjects. Read More

Eur J Heart Fail 2019 Apr 2. Epub 2019 Apr 2.

Department of Cardiology, National Heart Center, Singapore.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Cardiology, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.

A 14-year-old boy of Asian origin presented with a history of bluish discolouration of the finger and toenail bed with associated mild fatiguability on exertion since early childhood. Clinical examination revealed bilaterally symmetric uniform central cyanosis with no associated clubbing. Cardiovascular and respiratory system examination was normal. Read More

Endosc Int Open 2019 Apr 21;7(4):E452-E458. Epub 2019 Mar 21.

Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.

 Image enhanced endoscopy (IEE) allows endoscopists to improve recognition and characterization of gastrointestinal neoplasia. The Asian Novel Bio-Imaging and Intervention Group (ANBIG) conducted a standardized training program in endoscopic diagnosis and treatment of early gastrointestinal cancers in Asia. We embarked on a study to investigate the effect of this module on endoscopic diagnosis of early gastrointestinal neoplasia. Read More

J Epidemiol 2019 Mar 30. Epub 2019 Mar 30.

Department of Preventive Cardiology, National Cerebral and Cardiovascular Center.

Background: Left atrial dimension (LAD) and other parameters on echocardiography have been reported to be associated with the risk of atrial fibrillation (AF). However, few studies have investigated the associations between echocardiographic parameters and the risk of AF in the Asian general population with a low AF incidence.

Methods: A prospective cohort study was performed in 1,424 individuals in the Suita study with echocardiographic parameters including LAD and no history of AF. Read More

F1000Res 2018 24;7:1334. Epub 2018 Aug 24.

School of Health Science and Psychology, Federation University, Ballarat, Victoria, 3350, Australia.

: The South Asian population have greater cardiovascular risk than their age-matched Caucasian counterparts, characterized by unfavorable biomarkers. South Asians may also be partially resistant to the pleiotropic benefits of physical activity on cardiovascular health. There is a current absence of studies that compare markers of cardio-metabolic health between Caucasians and South Asians employing resistance exercise. Read More

BMC Cardiovasc Disord 2019 Mar 29;19(1):75. Epub 2019 Mar 29.

UCSF Department of Epidemiology and Biostatistics, 550 16th St, San Francisco, CA, 94158, USA.

Background: South Asians have disproportionately high rates of cardiovascular disease. Dyslipidemia, a contributing factor, may be influenced by lifestyle, which can vary by religious beliefs. Little is known about South Asian religions and associations with dyslipidemia. Read More

JAMA Netw Open 2019 Mar 1;2(3):e191540. Epub 2019 Mar 1.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Importance: The association of diabetic microvascular complications such as diabetic retinopathy (DR) and diabetic kidney disease (DKD) with mortality in populations is not clear.

Objective: To examine the association of DR and DKD separately and jointly with all-cause and cardiovascular disease (CVD) mortality in a multiethnic Asian population.

Design, Setting, And Participants: A population-based cohort study was conducted including 2964 adults between the ages of 40 and 80 years with diabetes who participated in the Singapore Epidemiology of Eye Diseases study (baseline, 2004-2011). Read More

JAMA Netw Open 2019 Mar 1;2(3):e191474. Epub 2019 Mar 1.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: Understanding birth cohort-specific tobacco smoking patterns and their association with total and cause-specific mortality is important for projecting future deaths due to tobacco smoking across Asian populations.

Objectives: To assess secular trends of tobacco smoking by countries or regions and birth cohorts and evaluate the consequent mortality in Asian populations.

Design, Setting, And Participants: This pooled meta-analysis was based on individual participant data from 20 prospective cohort studies participating in the Asia Cohort Consortium. Read More

JAMA Netw Open 2019 Mar 1;2(3):e191145. Epub 2019 Mar 1.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Importance: The clinical characteristics and outcomes of women and men with atrial fibrillation (AF) are reported to be different. However, whether sex-related differences extend to patients' symptom burden and perceived quality of life (QOL) or the management pattern of AF has been rarely studied, particularly in Asian countries.

Objective: To assess the differences in symptoms, treatment, and QOL between Japanese female and male patients with AF. Read More

Lipids Health Dis 2019 Mar 28;18(1):74. Epub 2019 Mar 28.

Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University and Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.

Background: CD14 polymorphisms are associated with an increased risk of cardiovascular events. So far, many studies have been conducted, whereas the results were not always consistent.

Materials And Methods: Twenty-six articles involving thirty-seven datasets were recruited to evaluate the association between rs2569190 (9413 patients and 7337 controls), C-159T (4813 patients and 2852 controls) polymorphisms and cardiovascular diseases in a meta-analysis. Read More

Asian Cardiovasc Thorac Ann 2019 Mar 28:218492319841977. Epub 2019 Mar 28.

1 Department of Cardiology, Gaziosmanpasa Hospital, Faculty of Medicine, Istanbul Yeni Yuzyil University, Istanbul, Turkey.

We report the case of a 73-year-old man with diffuse calcification in both upper and lower limb arteries. This condition, termed Mönckeberg's arteriosclerosis, was accompanied by three-vessel disease needing coronary artery bypass grafting. The diagnosis of arteriosclerosis was further verified by histopathology. Read More

Arrhythm Electrophysiol Rev 2019 Mar;8(1):19-27

Montefiore Medical Center, Albert Einstein College of Medicine Bronx, NY, US.

Brugada syndrome (BrS) is one of the most common causes of sudden cardiac death in normal structural heart individuals. First characterised in 1992, the global prevalence of BrS is unclear, with estimates placing it at around 0.05% and presenting most frequently in southeast Asian countries. Read More

Int J Stroke 2019 Mar 27:1747493019840931. Epub 2019 Mar 27.

1 Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

Background: Recent prospective registration studies of transient ischemic attack in Western countries demonstrated that large artery atherosclerosis is the highest risk etiology for early stroke recurrence under urgent evaluation and treatment. On the other hand, some limited transient ischemic attack studies from East Asian countries showed transient ischemic attack patients due to small vessel occlusion were at a higher early stroke risk.

Aims: We aimed to assess the risk for early stroke in small vessel occlusion-transient ischemic attack patients in a Japanese large transient ischemic attack registry. Read More

Asian Cardiovasc Thorac Ann 2019 Mar 27:218492319841178. Epub 2019 Mar 27.

2 Department of Engineering Design, Faculty of Mechanical and Electrical Engineering, Damascus University, Damascus, Syria.

Stroke 2019 Mar 27:STROKEAHA118024210. Epub 2019 Mar 27.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Chest and Heart Hospital, United Kingdom (G.Y.H.L.).

Background and Purpose- Although rivaroxaban 15 mg (R15) was only given to patients with creatinine clearance (CrCl) ≤50 mL/min in the pivotal clinical trial, this dose has been commonly prescribed in Asian patients with nonvalvular atrial fibrillation regardless of renal function. There is a paucity of information on the clinical outcomes of R15 compared with rivaroxaban 20 mg (R20) in patients with CrCl ≥50 mL/min. This study aimed to examine the effectiveness and safety of 2 doses of rivaroxaban in Asian patients with atrial fibrillation and CrCl ≥50 mL/min. Read More

Asian Pac J Allergy Immunol 2019 Mar 24. Epub 2019 Mar 24.

Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Eperisone is a commonly prescribed oral muscle relaxant, but few studies have been conducted of eperisone-induced hypersensitivity reactions.

Objective: The purpose of this study was to investigate the clinical manifestations of eperisone-induced immediate-type hypersensitivity, and to evaluate the role of an intradermal test (IDT) in eperisone-induced anaphylaxis.

Methods: This study was based on a retrospective review of medical records from 23 patients diagnosed as eperisone-induced immediate-type hypersensitivity with certain or probable causality. Read More

Rheumatol Int 2019 Mar 22. Epub 2019 Mar 22.

Department of Pediatric Cardiology and Rheumatology, Medical University of Lodz, Sporna 36/50 street, 91-738, Lodz, Poland.

Kawasaki disease (KD) is an acute, self-limited, systemic vasculitis and the most common cause of acquired coronary artery disease in pediatric population in the developed countries. It occurs mostly in Asian countries; however, due to better access to diagnostic and imaging tests, it is more frequently diagnosed among pediatric patients in Poland. The aim of this study was to describe the clinical course with special interest in cardiac involvement, treatment and follow-up of Polish patients with KD. Read More

PLoS One 2019 20;14(3):e0208687. Epub 2019 Mar 20.

State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.

There is limited evidence linking the impacts of reduced air pollution on hospital admissions. The potential biological mechanisms are still not completely understood. This study examined the effects of mitigated ambient pollution on hospital admissions and inflammatory biomarker levels in chronic obstructive pulmonary disease (COPD) COPD patients. Read More

J Am Heart Assoc 2019 Apr;8(7):e010744

2 Division of Primary Care and Population Health Stanford University School of Medicine Stanford CA.

Background Asian-American subgroups (Asian-Indian, Chinese, Filipino, Korean, Japanese, and Vietnamese) display varied cardiovascular disease mortality patterns, especially at younger ages. This study aims to examine the years of potential life lost because of ischemic heart disease and cerebrovascular disease among the 6 largest Asian-American subgroups compared with non-Hispanic whites. Methods and Results We used National Center for Health Statistics Multiple Causes of Death mortality files from 2003 to 2012 to calculate race-specific life expectancy, mean years of potential life lost, and years of potential life lost per 100 000 population for each Asian subgroup and non-Hispanic whites. Read More

PLoS One 2019 18;14(3):e0214186. Epub 2019 Mar 18.

[This corrects the article DOI: 10.1371/journal.pone. Read More

Asian J Surg 2019 Mar 14. Epub 2019 Mar 14.

Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Engineering Research Center of Vascular Prostheses, Beijing, China. Electronic address:

Objective: The aim of our study was to assess how much renal malperfusion increases the risk of early and late mortality in patients with acute type A aortic dissection (ATAAD) undergoing surgical repair.

Methods: This study included 218 patients with ATAAD undergoing surgical repair using the total arch replacement and frozen elephant trunk technique. Mean age was 47. Read More

J Card Fail 2019 Mar 12. Epub 2019 Mar 12.

Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Peter Munk Cardiac Centre and the Joint Department of Medical Imaging, University Health Network. Electronic address:

Background: Several known traditional cardiovascular risk factors contribute to the development of heart failure (HF); however, whether ethnicity is also an important predictor is not well-established. We determined the incidence of hospitalization for HF among ethnic groups in Ontario, Canada and examined differences in risk factor prevalence that may contribute to disparities in HF hospitalization incidence between groups.

Methods And Results: We conducted a retrospective observational study from 2008 to 2012 using a linked cohort derived from population-based health administrative, clinical and survey datasets. Read More

BMJ Open 2019 Mar 13;9(3):e022479. Epub 2019 Mar 13.

Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: Successful treatment of acute coronary syndrome (ACS) relies on its rapid recognition. It is unclear whether the accepted presentation of chest pain applies to different ethnic groups. We thus examined potential ethnic variations in ACS symptoms and clinical care outcomes in white, South Asian and Chinese patients. Read More

J Cancer Res Clin Oncol 2019 Mar 13. Epub 2019 Mar 13.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.

Background: Dose-response meta-analysis (DRMA) has been widely used in exploring cancer risk factors. Understanding the quality of published DRMAs on cancer risk factors may be beneficial for informed prevention for cancer.

Methods: We searched eligible DRMAs from 1st January 2011 to 31st-July-2017. Read More

Cent Asian J Glob Health 2018 8;7(1):321. Epub 2018 Aug 8.

Department of Population Health and Social Sciences, Kazakhstan School of Public Health, Medical University, Almaty, Republic of Kazakhstan.

Cardiovascular diseases (CVD) are now the number one cause of death in low- and middle-income countries, including those in Central Asia (CA). Low- and middle-income countries (LMICs) bear a disproportionate and growing burden of CVD, which constitutes a challenge to national development. CVD account for more than 43% of cases of disability and 9. Read More

Case Rep Cardiol 2019 4;2019:7124072. Epub 2019 Feb 4.

Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA.

Moyamoya disease is a rare condition that is primarily reported in Asian populations, characterized by stenoocclusive intracranial angiopathy with small, fragile, and multiple collateral vessel formation. Extracranial complications, mainly abnormalities within the renal vasculature, have been described; however, there are very few case reports of cardiovascular complications in patients with Moyamoya disease. We report a 26-year-old Caucasian female with known Moyamoya disease who presented with both typical and atypical chest pain, mimicking symptoms of a previous non-ST-elevation myocardial infarction. Read More

Biomed Environ Sci 2019 Feb;32(2):75-86

National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, and Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.

Objective: The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease (CVD) risk in Chinese adults.

Methods: We performed a cross-sectional analysis in 549 subjects without previous diagnosis or clinical symptoms of CVD in a community cohort of middle-aged Chinese adults. The participants underwent coronary computed tomography (CT) angiography for the evaluation of the presence and composition of coronary plaques. Read More

Eur J Prev Cardiol 2018 Dec 6:2047487318817899. Epub 2018 Dec 6.

5 Sports and Exercise Medicine Laboratory, Korea Maritime and Ocean University, Korea.

Background: Clinical exercise interventions show that combining moderate to vigorous intensity physical activity (MVPA) and muscle strengthening exercise (MSE) has more favourable cardiometabolic health benefits than engaging in only one mode of physical activity. However, few studies have examined these associations among community-based samples and none among Asian adults.

Methods: This cross-sectional analysis included 9120 participants aged 20-80 years from the 2014-2015 Korea National Health and Nutritional Examination Survey. Read More

JAMA Pediatr 2019 Mar 11. Epub 2019 Mar 11.

Division of Research, Cardiovascular and Metabolic Conditions Section, Kaiser Permanente Northern California, Oakland.

Importance: Infant temperament is associated with excess weight gain or childhood obesity risk in samples of healthy individuals, although the evidence has been inconsistent. To our knowledge, no prior research has examined this topic among children exposed to gestational diabetes mellitus (GDM) in utero.

Objective: To prospectively evaluate infant temperament in association with overweight and obesity status at ages 2 to 5 years among children born to mothers who experienced GDM. Read More

Environ Int 2019 May 7;126:552-559. Epub 2019 Mar 7.

Department of Occupational and Environmental Health, Peking University School of Public Health, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Institute of Environmental Medicine, Beijing, China. Electronic address:

Numerous epidemiologic studies on adverse health effects of air pollution have been well documented; however, assessment on health benefits of air quality improvement from air pollution control measures has been limited in developing countries. We assessed the mortality benefits associated with air pollution improvement over 11 years in Guangzhou, China (2006-2016). A time series analysis with Generalized additive Poisson models was used to estimate mortality effects of ozone (O) and nitrogen dioxide (NO), adjusting for time trend, day of week, public holiday, temperature and relative humidity. Read More

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.

Alzheimer's disease (AD) is a major health problem worldwide, with no effective treatment approach. Curcumin is the main ingredient of turmeric traditionally used in Asian medicine. Several experimental studies have indicated the protective effect of curcumin and its novel formulations in AD. Read More

J Hum Hypertens 2019 Mar 7. Epub 2019 Mar 7.

Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism is an established genetic risk of hypertension, diabetes, and coronary heart diseases in Asian population. Previous experimental data showed ALDH2 regulated inflammation, a potential mechanism of heart failure with preserved ejection fraction (HFpEF). However, clinically, the association between ALDH2 polymorphism and incidence of HFpEF remains unknown. Read More