5,281 results match your criteria Asia-Pacific journal of ophthalmology Philadelphia Pa.[Journal]


Impact of low-level viraemia on virological failure among Asian children with perinatally acquired HIV on first-line combination antiretroviral treatment: a multicentre, retrospective cohort study.

J Int AIDS Soc 2020 Jul;23(7):e25550

Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.

Introduction: The clinical relevance of low-level viraemia (LLV) and virological outcomes among children living with HIV (CLHIV) remains controversial. This study aimed to determine the impact of LLV on virological failure (VF) among Asian CLHIV on first-line combination antiretroviral therapy (cART).

Methods: CLHIV aged <18 years, who were on first-line cART for ≥12 months, and had virological suppression (two consecutive plasma viral load [pVL] <50 copies/mL) were included. Read More

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http://dx.doi.org/10.1002/jia2.25550DOI Listing

Pest categorisation of .

EFSA J 2019 Jul 30;17(7):e05765. Epub 2019 Jul 30.

The EFSA Panel on Plant Health (PLHP) performed a pest categorisation of (Lepidoptera: Noctuidae) for the EU. is widely distributed across South and East Asia and Oceania. It is established in tropical and subtropical regions where there are no, or few, frost days each year. Read More

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http://dx.doi.org/10.2903/j.efsa.2019.5765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009099PMC

Asia-Pacific Consensus Statement on the Management of Peripheral Artery Disease: A Report from the Asian Pacific Society of Atherosclerosis and Vascular Disease Asia-Pacific Peripheral Artery Disease Consensus Statement Project Committee.

J Atheroscler Thromb 2020 Jul 4. Epub 2020 Jul 4.

Department of Clinical Epidemiology, University of the Philippines College of Medicine.

Background: Peripheral artery disease (PAD) is the most underdiagnosed, underestimated and undertreated of the atherosclerotic vascular diseases despite its poor prognosis. There may be racial or contextual differences in the Asia-Pacific region as to epidemiology, availability of diagnostic and therapeutic modalities, and even patient treatment response. The Asian Pacific Society of Atherosclerosis and Vascular Diseases (APSAVD) thus coordinated the development of an Asia-Pacific Consensus Statement (APCS) on the Management of PAD. Read More

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http://dx.doi.org/10.5551/jat.53660DOI Listing

Photodynamic treatment with purpurin 18 effectively inhibits triple negative breast cancer by inducing cell apoptosis.

Lasers Med Sci 2020 Jul 5. Epub 2020 Jul 5.

School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

This study aims to evaluate the photodynamic efficacy of purpurin 18 (pu-18) on triple negative breast cancer both in vitro and in vivo. Two states of 4T1 cells, 2D culture and 3D spheroids, were used to evaluate the photodynamic action of pu-18 in vitro. The in vitro study results indicated that for the 4T1 2D cell culture, the photodynamic therapy (PDT) treatment showed significant photocytotoxicity at low pu-18 concentrations following light irradiation. Read More

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http://dx.doi.org/10.1007/s10103-020-03035-wDOI Listing

The incidence of squamous cell carcinoma of the oral tongue is rising in young non-smoking women: An international multi-institutional analysis.

Oral Oncol 2020 Jul 1;110:104875. Epub 2020 Jul 1.

Central Clinical School, University of Sydney, Parramatta Road, Camperdown, NSW 2050, Australia; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Missenden Road, Camperdown, NSW 2050, Australia. Electronic address:

Purpose: Increasing evidence is accumulating for an alarming rising incidence of oral tongue SCC in a younger cohort, particularly in developed countries. The aim of this study is to analyse the change in incidence of OSCC in patients under the age of 45 in developed nations in the Asia-Pacific region.

Patients And Methods: Population data was extracted from the Australian Cancer Incidence and Mortality 2017 database and National Registry of Diseases Office, Singapore to allow calculation of the incidence in the Australian and Singaporean populations. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104875DOI Listing

Appraisal of Philippine CPGs Using AGREE II: Improvement needed for rigour, applicability and editorial independence.

J Clin Epidemiol 2020 Jul 1. Epub 2020 Jul 1.

Asia-Pacific Center for Evidence-Based Healthcare, Mirasol Bldg, 854 Apacible St, Manila 1000, Philippines; Kalusugan ng Mag-Ina (Health of Mother and Child), Inc., Green Grove Villa, Lantana Road, New Manila, Quezon City, Philippines.

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.036DOI Listing

Adoption of enterprise architecture for healthcare in AeHIN member countries.

BMJ Health Care Inform 2020 Jul;27(1)

School of Public Health and Community Medicine, UNSW Sydney, Sydney, New South Wales, Australia.

Background: Healthcare organisations are undergoing a major transformational shift in the use of information and digital health technologies. Enterprise architecture (EA) has been incrementally adopted in many healthcare organisations globally to facilitate this change. EA can increase the effectiveness of an organisation's digital health capabilities and resources. Read More

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http://dx.doi.org/10.1136/bmjhci-2020-100136DOI Listing

Dietary supplementation of 25-hydroxycholecalciferol improves cardiac function and livability in broiler breeder hens-amelioration of blood pressure and vascular remodeling.

Poult Sci 2020 Jul 17;99(7):3363-3373. Epub 2020 Apr 17.

Department of Animal Science, National Chung Hsing University, Taichung, Taiwan; Innovation and Development Center of Sustainable Agriculture (IDCSA), National Chung Hsing University, Taichung, Taiwan; The IEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan; Research Center for Sustainable Energy and Nanotechnology, National Chung Hsing University, Taichung, Taiwan. Electronic address:

A supplement of 69 μg 25-hydroxycholecalciferol (25-OH-D3)/kg feed suppressed the mortality in feed-restricted broiler breeder hens and in hens allowed ad libitum feed intake (Ad-hens) in a feeding trial from age 26 to 60 wk. Outcomes for the mechanisms found that 25-OH-D3 relieved systemic hypoxia, pathological cardiac remodeling and arrhythmias, and hepatopathology to improve hens' livability. In the study, we further evaluated the effect of 25-OH-D3 on blood pressure and vascular remodeling relative to cardiac pathogenesis of sudden death (SD). Read More

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http://dx.doi.org/10.1016/j.psj.2020.03.015DOI Listing

Chronic encephalopathy and locked-in state due to scrub typhus related CNS vasculitis.

J Neuroimmunol 2020 Jun 24;346:577303. Epub 2020 Jun 24.

Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Background: Scrub Typhus, prevalent in Asia-Pacific region, often has neurological manifestations in the setting of acute febrile illness, as acute encephalitis syndrome.

Case Report: A 20-year-old female, from western Rajasthan, India presented with calf pain followed by nausea, vomiting, dizziness, and sequentially progressive weakness of limbs, anarthria and loss of bladder control over 10 days. MRI Brain showed T2-weighted and FLAIR hyperintense lesions in corpus callosum, subcortical and periventricular white matter, basal ganglia, thalamus, brainstem and cerebellum producing starry sky appearance with diffusion restriction. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2020.577303DOI Listing

Forensic evaluation of the Asia Pacific ancestry-informative MAPlex assay.

Forensic Sci Int Genet 2020 Jun 20;48:102344. Epub 2020 Jun 20.

Office of the Chief Forensic Scientist, Forensic Services Department, Victoria Police, Macleod, Australia; National Centre for Forensic Studies, Faculty of Science & Technology, University of Canberra, ACT, Australia.

DNA intelligence, and particularly the inference of biogeographical ancestry (BGA) is increasing in interest, and relevance within the forensic genetics community. The majority of current MPS-based forensic ancestry-informative assays focus on the differentiation of major global populations. The recently published MAPlex (Multiplex for the Asia Pacific) panel contains 144 SNPs and 20 microhaplotypes and aims to improve the differentiation of populations in the Asia Pacific region. Read More

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http://dx.doi.org/10.1016/j.fsigen.2020.102344DOI Listing

Twelve Weeks of Ledipasvir/Sofosbuvir All-oral Regimen for Patients with Chronic Hepatitis C Genotype 2 Infection: Integrated Analysis of Three Clinical Trials.

Hepatol Res 2020 Jul 2. Epub 2020 Jul 2.

First Department of Internal Medicine, Gastroenterology and Hepatology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.

Aim: The combination of ledipasvir and sofosbuvir (LDV/SOF) has been approved for the treatment of various hepatitis C (HCV) genotypes across many countries. This article presents an integrated analysis of three prospective phase 2/3 trials in the Asia-Pacific region to evaluate the efficacy and safety of 12-weeks of LDV/SOF in HCV genotype 2 patients without cirrhosis or with compensated cirrhosis.

Methods: 200 patients were included in the integrated analysis. Read More

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http://dx.doi.org/10.1111/hepr.13546DOI Listing

Elevating the role of carers in rheumatoid arthritis management in the Asia-Pacific region.

Int J Rheum Dis 2020 Jul 1. Epub 2020 Jul 1.

Johnson & Johnson Pte Ltd, Singapore, Singapore.

Aim: Carers may offer valuable insight into the true health status of patients with rheumatoid arthritis (RA). This multinational, multi-stakeholder, exploratory study in Australia, China and Japan aimed to enrich our understanding of the role and potential impact of carers on RA management.

Method: This study used a 2-phase sequential mixed methods approach involving 3 key stakeholder groups: rheumatologists, RA patients and carers. Read More

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http://dx.doi.org/10.1111/1756-185X.13893DOI Listing
July 2020
1.771 Impact Factor

Medication understanding and health literacy among patients with multiple chronic conditions: A study conducted in Bangladesh.

J Public Health Res 2020 Jun 18;9(1):1792. Epub 2020 Jun 18.

Department of Pharmacy, Daffodil International University, Dhaka, Bangladesh.

Medication understanding is critical for patients who suffer from multiple chronic conditions in order to reduce medication error and is often associated with poor health outcomes and low adherence. This study aims to identify the gap of medication knowledge among multiple chronic condition patients in Bangladesh, in order to aid physicians and other healthcare providers in improving health literacy. Individual interviews of a convenience sample of multiple chronic condition patients in Bangladesh were held where they were asked a number of questions for assessing medication related literacy. Read More

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http://dx.doi.org/10.4081/jphr.2020.1792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315107PMC

Enhancement of Mechanical Properties and Porosity of Concrete Using Steel Slag Coarse Aggregate.

Materials (Basel) 2020 Jun 26;13(12). Epub 2020 Jun 26.

Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Assam 781039, India.

This paper investigates the possibility of utilizing steel slags produced in the steelmaking industry as an alternative to burnt clay brick aggregate (BA) in concrete. Within this context, physical, mechanical (i.e. Read More

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http://dx.doi.org/10.3390/ma13122865DOI Listing

Risk factors modifying the double burden of malnutrition of young children in Thailand.

Matern Child Nutr 2020 Jun 30:e12910. Epub 2020 Jun 30.

UNICEF East Asia & Pacific Regional Office, Bangkok, Thailand.

Thailand is now faced with a double burden of malnutrition. Using nationally representative data from the 2015-2016 Multiple Indicator Cluster Survey, we utilized multinomial logistic regression models to examine factors associated with stunting only, wasting only, overweight only, concurrent stunting and overweight, and concurrent stunting and wasting among children 0-59 months of age (n = 11,068). The prevalences of <5 stunting only (height-for-age Z score < -2 SD) and wasting only (WHZ < -2 SD) were 8. Read More

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http://dx.doi.org/10.1111/mcn.12910DOI Listing

National nutrition strategies that focus on maternal, infant, and young child nutrition in Southeast Asia do not consistently align with regional and international recommendations.

Matern Child Nutr 2020 Jun 30:e12937. Epub 2020 Jun 30.

Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.

We examined the consistency of national nutrition strategies and action plans (NNS) focusing on maternal, infant, and young child nutrition in Southeast Asia with regional and international recommendations. Between July and December 2017, we identified and extracted information on context, objectives, interventions, indicators, strategies, and coordination mechanisms from the most recent NNS in nine Southeast Asian countries. All NNS described context, objectives, and the following interventions: antenatal care, micronutrient supplementation during pregnancy, breastfeeding promotion, improved complementary feeding, nutrition in emergencies, and food fortification or dietary diversity. Read More

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http://dx.doi.org/10.1111/mcn.12937DOI Listing
June 2020
2.973 Impact Factor

A review of HIV pre-exposure prophylaxis (PrEP) programmes by delivery models in the Asia-Pacific through the healthcare accessibility framework.

J Int AIDS Soc 2020 Jul;23(7):e25531

Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.

Introduction: In the Asia-Pacific, pre-exposure prophylaxis (PrEP) is a newly introduced public health intervention for minimizing HIV transmission, the coverage of which has remained limited. The best delivery models and strategies for broadening access of the vulnerable communities are not fully known. This review identified PrEP programmes reported in the Asia-Pacific, which were classified by delivery models and assessed with a healthcare accessibility framework. Read More

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http://dx.doi.org/10.1002/jia2.25531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326464PMC

Building climate change resilience by using a versatile toolkit for local governments and communities in rural Himalaya.

Environ Res 2020 May 12;188:109636. Epub 2020 May 12.

Southwest University, Beibei District, Chongqing, China. Electronic address:

With the impacts of climate disruption becoming more evident there has been an increase in the uptake of climate change adaptation "toolkits" to assist local governments build community resilience and adapt to the impacts of climate change. There is increasing attention and call for practitioners to adopt proactive and participatory approaches to help in the adaptive response planning process. One such toolkit is the International Council for Local Environmental Initiatives (ICLEI) Asian Cities Climate Change Resilience Network (ACCRN) Process (IAP). Read More

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http://dx.doi.org/10.1016/j.envres.2020.109636DOI Listing

Identification, management and outcomes of combination antiretroviral treatment failure in adolescents with perinatal HIV infection in Asia.

Clin Infect Dis 2020 Jun 26. Epub 2020 Jun 26.

Kirby Institute, UNSW Sydney, Australia.

Background: Combination antiretroviral therapy (cART) failure is a major threat to HIV programs, with implications for individual- and population-level outcomes. Adolescents with perinatally-acquired HIV infection (PHIVA) should be a focus for treatment failure given their poorer outcomes compared to children and adults.

Methods: Data (2014-2018) from a regional cohort of Asian PHIVA who received at least 6 months of continuous cART were analyzed. Read More

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http://dx.doi.org/10.1093/cid/ciaa872DOI Listing

Dual Challenge of Cancer and COVID-19: Impact on Health Care and Socioeconomic Systems in Asia Pacific.

JCO Glob Oncol 2020 Jun;6:906-912

Department of Radiation Oncology, Nizam's Institute of Medical Sciences, Hyderabad, India.

Coronavirus or COVID-19 is caused by severe acute respiratory syndrome coronavirus 2. The COVID-19 pandemic has resulted in social and economic disruption throughout the entire world. Each country is being challenged. Read More

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http://dx.doi.org/10.1200/GO.20.00227DOI Listing

Global scanning of cylindrospermopsin: Critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards.

Sci Total Environ 2020 Jun 2;738:139807. Epub 2020 Jun 2.

Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX 76798, USA; Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX 76798, USA; Institute of Biomedical Studies, Baylor University, Waco, TX 76798, USA. Electronic address:

Cylindrospermopsin (CYN), a cyanotoxin produced by harmful algal blooms, has been reported worldwide; however, there remains limited understanding of its potential risks to surface water quality. In the present study, we critically reviewed available literature regarding the global occurrence, bioaccumulation, and toxicity of CYN in aquatic systems with a particular focus on freshwater. We subsequently developed environmental exposure distributions (EEDs) for CYN in surface waters and performed probabilistic environmental hazard assessments (PEHAs) using guideline values (GVs). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139807DOI Listing

Management of patients with liver derangement during the COVID-19 pandemic: an Asia-Pacific position statement.

Lancet Gastroenterol Hepatol 2020 Jun 22. Epub 2020 Jun 22.

Department of Medicine and Therapeutics, and Medical Data Analytic Centre, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address:

The COVID-19 pandemic has spread rapidly worldwide. It is common to encounter patients with COVID-19 with abnormal liver function, either in the form of hepatitis, cholestasis, or both. The clinical implications of liver derangement might be variable in different clinical scenarios. Read More

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http://dx.doi.org/10.1016/S2468-1253(20)30190-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308747PMC

Comparative Overview of ST-Elevation Myocardial Infarction (STEMI) Epidemiology, Demographics, Management and Outcomes in 5 Asia-Pacific Countries - A Meta-Analysis.

Eur Heart J Qual Care Clin Outcomes 2020 Jun 25. Epub 2020 Jun 25.

Department of Cardiology, National Heart Centre Singapore, Singapore.

Aims: To gain insight into the differences in demographics of STEMI patients in Asia-Pacific, as well as inter-country variation in treatment and mortality outcomes.

Methods: Systematic review of published studies and reports from known registries in Australia, Japan, Korea, Singapore and Malaysia that began data collection after the year 2000. Supplementary self-report survey questionnaire on public health data answered by representative cardiologists working in these countries. Read More

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http://dx.doi.org/10.1093/ehjqcco/qcaa057DOI Listing

Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naïve first-episode major depressive disorder.

BMC Psychiatry 2020 Jun 24;20(1):333. Epub 2020 Jun 24.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.

Background: The alterations of biological markers are thought to be effective tools to understand the pathophysiology and management of major depressive disorder (MDD). A lot of researches has implied many markers for depression, but any of them fully discovered the association between the markers and depression. The present study investigated the serum levels of amino acids and non-enzymatic antioxidants in major depression, and also explained their association with depression. Read More

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http://dx.doi.org/10.1186/s12888-020-02738-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315550PMC
June 2020
2.210 Impact Factor

Special Issue "Selected Papers from the 8th Asia-Pacific NMR (APNMR) Symposium: Recent Advances in NMR Spectroscopy".

Int J Mol Sci 2020 Jun 22;21(12). Epub 2020 Jun 22.

School of Biological Sciences, 60 Nanyang Drive, Nanyang Technological University, Singapore 637551, Singapore.

Asia-Pacific NMR (APNMR) has been an important scientific event in the region, engaging a large number of NMR scientists from academia and industries [... Read More

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http://dx.doi.org/10.3390/ijms21124419DOI Listing

Single-operator cholangioscopy: more good numbers, with a few caveats.

Authors:
Christopher Khor

Endoscopy 2020 Jul 24;52(7):533-534. Epub 2020 Jun 24.

Department of Gastroenterology and Hepatology, Singapore General Hospital, Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1055/a-1172-9933DOI Listing

Operational efficiency of Asia-Pacific airports.

J Air Transp Manag 2014 Aug 10;40:16-24. Epub 2014 Jun 10.

School of Economics and Finance, Massey University, Palmerston North, New Zealand.

Airports are important drivers of economic development and thus under tremendous pressure from emerging competitors. However, few studies have analysed the operational efficiency of Asia-Pacific airports. This study therefore evaluated the operational efficiency of 21 Asia-Pacific airports between 2002 and 2011. Read More

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http://dx.doi.org/10.1016/j.jairtraman.2014.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148862PMC

E-learning: A Tool to Upgrade the Skills of Health Workers to Address Betel Quid and Areca Nut Chewing.

Subst Use Misuse 2020 ;55(9):1525-1527

National Institute for Health Innovation (NIHI), School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

In the Asia-Pacific region, betel quid and areca nut chewing is a public health concern that requires immediate attention. There is a need to improve knowledge about the harmful effects of betel quid and areca nut chewing and train health care professionals to provide preventive interventions. To introduce and evaluate the Pacific Open Learning Health Net (POLHN) online courses about the dangers of betel quid and areca nut. Read More

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http://dx.doi.org/10.1080/10826084.2019.1666143DOI Listing
January 2020

Areca Nut and Betel Quid Control Interventions: Halting the Epidemic.

Subst Use Misuse 2020 ;55(9):1552-1559

Center for Global Health, U.S. National Cancer Institute, Bethesda, Maryland, USA.

: Areca nut (AN) and betel quid (BQ) are classified as Group 1 carcinogens. There are approximately 600 million AN/BQ users globally; the majority of users live in the Asia-Pacific region which, correspondingly, has the highest rates of oral cancer. Despite significant disease burden associated with AN/BQ use, there have been no systematic reviews of interventions to reduce product use. Read More

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http://dx.doi.org/10.1080/10826084.2019.1686022DOI Listing
January 2020

The Past, Present and Future of Literature Pertaining to Betel () Nut: A Citation Analysis.

Subst Use Misuse 2020 ;55(9):1403-1412

Department of Biostatistics, National Drug Dependence Treatment Centre and Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.

Betel (areca) nut has recently received interest from researchers and policy makers for its role as a psychoactive substance. It was historically limited to Asia-pacific region, but with the advent of globalization, it has become an equally challenging public health problem across the globe. Previously published literature can give us valuable insights in terms of historical interest and understanding related to betel nut. Read More

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http://dx.doi.org/10.1080/10826084.2019.1660677DOI Listing
January 2020

Betel Nut Use in Vanuatu: Investigating Opportunities to Reduce Harms to Health.

Subst Use Misuse 2020 ;55(9):1457-1464

National Institute for Health Innovation (NIHI), School of Population Health, The University of Auckland, Auckland, New Zealand.

Betel nut chewing is a public health concern in the Asia-Pacific region and is an emerging issue in Vanuatu. Despite the significant health risks associated with betel nut chewing, few interventions have been undertaken to reduce its harm. To investigate betel nut use in Vanuatu and to identify opportunities to reduce its harm and possible interventions, framing the responses using the World Health Organization's MPOWER tobacco control model. Read More

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http://dx.doi.org/10.1080/10826084.2020.1716803DOI Listing
January 2020

Erratum to: Effects of dietary protease on immune responses of weaned pigs.

J Anim Sci Technol 2020 May 31;62(3):427-428. Epub 2020 May 31.

Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea.

[This corrects the article DOI: 10.5187/jast.2020. Read More

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http://dx.doi.org/10.5187/jast.2020.62.3.427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288237PMC

Dietary protease improves growth rate and protein digestibility of growing-finishing pigs.

J Anim Sci Technol 2020 May 31;62(3):313-320. Epub 2020 May 31.

Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea.

This research was performed to investigate the hypothesis that dietary mono-component protease (PRO) might improve growth performance, nutrient digestibility, and carcass characteristics of growing-finishing pigs. A total of eighty-four pigs [Duroc × (Landrace × Yorkshire), 25.3 ± 2. Read More

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http://dx.doi.org/10.5187/jast.2020.62.3.313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288229PMC

Effectiveness of Decision Aid in Men with Localized Prostate Cancer: a Multicenter Randomized Controlled Trial at Tertiary Referral Hospitals in an Asia Pacific Country.

J Cancer Educ 2020 Jun 20. Epub 2020 Jun 20.

Department of Surgery, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.

There are several treatment options for localized prostate cancer with very similar outcome but vary in terms of technique and side effect profiles and risks. Considering the potential difficulty in choosing the best treatment, a patient decision aid (PDA) is used to help patients in their decision-making process. However, the use and applicability of PDA in a country in Asia Pacific region like Malaysia is still unknown. Read More

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http://dx.doi.org/10.1007/s13187-020-01801-6DOI Listing

Incidence of suboptimal response to tumor necrosis factor antagonist therapy in inflammatory bowel disease in newly industrialised countries: The EXPLORE study.

Dig Liver Dis 2020 Jun 17. Epub 2020 Jun 17.

Takeda Pharmaceutical International AG, Singapore.

Background: Incidence of inflammatory bowel disease (IBD) is increasing in newly industrialised countries (NICs); however, data on suboptimal response to anti-tumor necrosis factor (anti-TNF) agents are limited.

Objectives: To assess incidence and indicators of suboptimal response to first anti-TNF therapy in IBD patients in NICs.

Methods: A chart review was conducted in ten countries from Asia-Pacific (APAC), Latin America (LatAm), and Russia and the Middle East (RME) regions among patients diagnosed with ulcerative colitis (UC) or Crohn's disease (CD), initiating anti-TNF therapy in 2010-2015. Read More

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http://dx.doi.org/10.1016/j.dld.2020.05.031DOI Listing

IQ driving QI: the Asia Pacific Consortium on Osteoporosis (APCO): an innovative and collaborative initiative to improve osteoporosis care in the Asia Pacific.

Osteoporos Int 2020 Jun 19. Epub 2020 Jun 19.

Queen Elizabeth Hospital, Hong Kong, Hong Kong SAR.

Asia Pacific Consortium on Osteoporosis (APCO) comprises of clinical experts from across the Asia Pacific region, uniting to develop solutions to problems facing osteoporosis management and care. The vision of APCO is to reduce the burden of osteoporosis and fragility fractures in the Asia Pacific region.

Introduction: The Asia Pacific (AP) region comprises 71 countries with vastly different healthcare systems. Read More

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http://dx.doi.org/10.1007/s00198-020-05495-wDOI Listing

Risk of cardiovascular events and death associated with initiation of SGLT2 inhibitors compared with DPP-4 inhibitors: an analysis from the CVD-REAL 2 multinational cohort study.

Lancet Diabetes Endocrinol 2020 Jul;8(7):606-615

George Institute for Global Health, Sydney, NSW, Australia; Saint Luke's Mid America Heart Institute, Kansas City, MO, USA; University of Missouri-Kansas City, Kansas City, MO, USA; University of New South Wales in Sydney, Sydney, NSW, Australia.

Background: Cardiovascular outcome trials have shown cardiovascular benefit with sodium-glucose co-transporter-2 (SGLT2) inhibitors in patients with type 2 diabetes, whereas dipeptidyl peptidase-4 (DPP-4) inhibitors have not shown an effect. We aimed to address knowledge gaps regarding the comparative effectiveness of SGLT2 inhibitor use in clinical practice (with DPP-4 inhibitor use as an active comparator) across a range of cardiovascular risks and in diverse geographical settings.

Methods: In this comparative cohort study, we used data from clinical practice from 13 countries in the Asia-Pacific, Middle East, European, and North American regions to assess the risk of cardiovascular events and death in adult patients with type 2 diabetes newly initiated on SGLT2 inhibitors compared with those newly initiated on DPP-4 inhibitors. Read More

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http://dx.doi.org/10.1016/S2213-8587(20)30130-3DOI Listing

Qualitative risk assessment of transmission pathways of highly pathogenic avian influenza (HPAI) virus at live poultry markets in Dhaka city, Bangladesh.

Zoonoses Public Health 2020 Jun 19. Epub 2020 Jun 19.

Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.

Analysis of environmental samples obtained from the Live Poultry Markets (LPMs) of Dhaka City, Bangladesh, has revealed that the highest degree of prevalence of highly pathogenic avian influenza A (HPAI, H5N1), besides other subtypes of the LPAI virus, poses the plausible risk of transmission of these viruses between human and poultry species. The present study was conducted using the OIE risk analysis framework to assess the risk level of each pathway successively. The estimated risk parameters were integrated towards to obtain the overall risk level for each specific HPAI transmission pathway using the matrix adapted by Cristobel Zepeda accompanying other expert consultations. Read More

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http://dx.doi.org/10.1111/zph.12746DOI Listing

The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease.

Curr Microbiol 2020 Jun 15. Epub 2020 Jun 15.

Department of Microbiology, School of Medicine, Nanchang University, Nanchang, Jiangxi, People's Republic of China.

Enterovirus 71 (EV71) is the main pathogen of the hand, foot, and mouth disease. It was firstly isolated from sputum specimens of infants with central nervous system diseases in California in 1969, and has been repeatedly reported in various parts of the world, especially in the Asia-Pacific region. EV71 3C protein is a 183 amino acid cysteine protease that can cleave most structural and non-structural proteins of EV71. Read More

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http://dx.doi.org/10.1007/s00284-020-02082-4DOI Listing

The Role of the Opinion Leader Research Process in Informing Policy Making for Improved Nutrition: Experience and Lessons Learned in Southeast Asia.

Curr Dev Nutr 2020 Jun 22;4(6):nzaa093. Epub 2020 May 22.

Alive & Thrive Southeast Asia, FHI 360, Hanoi, Vietnam.

Opinion leader research (OLR) has been widely used in public health to identify influential persons or organizations to affect health care practice, inform policy-making processes, and help shape communication strategies. We used OLR to gather information related to barriers and possible solutions to guide strategic engagement for strengthening policy making for improved maternal, infant, and young child nutrition (MIYCN) practices in 5 Southeast Asian countries-Cambodia, Laos, Indonesia, Timor-Leste, and Thailand. In most countries, MIYCN policies and policymaker interest exist, but effective implementation and/or enforcement of current policies is weak. Read More

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http://dx.doi.org/10.1093/cdn/nzaa093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293205PMC

Adverse events following immunization with the live-attenuated recombinant Japanese encephalitis vaccine (IMOJEV®) in Taiwan, 2017-18.

Vaccine 2020 Jul 13;38(33):5219-5222. Epub 2020 Jun 13.

Department of Pediatrics, National Taiwan University Hospital, and National Taiwan University College of Medicine, No.8, Chung Shan S. Rd., Taipei 10041, Taiwan. Electronic address:

Background: Japanese encephalitis (JE) is a significant public health concern in the Asia-Pacific region, with a case-fatality rate of around 20% for those who develop encephalitis. Mouse-brain derived vaccines against JE have been used in the publicly funded national immunization program (NIP) in Taiwan since 1968. They were replaced with a live-attenuated recombinant vaccine (JE-CV, IMOJEV®) in May 2017. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.06.008DOI Listing

Palbociclib and beyond for the treatment of HR + HER2- metastatic breast cancer: an Asian-Pacific perspective and practical management guide on the use of CDK4/6 inhibitors.

Curr Med Res Opin 2020 Jul 2:1-11. Epub 2020 Jul 2.

Pantai Hospital, Kuala Lumpur, Malaysia.

Breast cancer is the most frequent cancer amongst women worldwide including in Asia where the incidence rate is rapidly increasing. Even with treatment, around 30% of patients with early breast cancer progress to metastatic disease, with hormone receptor positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) breast cancer the most common phenotype. First-line endocrine therapy targeting the estrogen receptor signaling pathway provides a median progression-free survival or time to progression of 6-15 months in HR + HER2- metastatic breast cancer. Read More

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http://dx.doi.org/10.1080/03007995.2020.1783646DOI Listing

The global burden of pancreatic cancer.

Arch Med Sci 2020 4;16(4):820-824. Epub 2020 May 4.

Service of Clinical Governance, Provincial Agency for Social and Sanitary Services, Trento, Italy.

Introduction: We provide here an overview on current worldwide epidemiology of pancreatic malignancies, obtained from Global Health Data Exchange (GHDx) and World Health Organization (WHO) repositories.

Material And Methods: Electronic searches for collecting information on pancreatic cancer epidemiology were performed in official repositories of GHDx and WHO, and retrieved data were then analyzed.

Results: Overall, 447 665 new cases of pancreatic cancer were recorded around the world in 2017 (58. Read More

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http://dx.doi.org/10.5114/aoms.2020.94845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286317PMC

A major new alliance in Australian healthcare: the Australian consensus framework for ethical collaboration in the healthcare sector.

Intern Med J 2020 Jun;50(6):679-684

Consumers Health Forum of Australia, Deakin, Australian Capital Territory, Australia.

The 'Australian Consensus Framework for Ethical Collaboration in the Healthcare Sector' (ACF) is an Australian initiative aimed at countering dysfunction and growing mistrust in the health sector through the development of a cross-sectoral consensus framework. The development of this framework arose from Australia's involvement in the Asia Pacific Economic Cooperative (APEC) and has since become the largest of its kind internationally, with over 70 signatories representing professional bodies, industry organisations, hospital and health services associations, regulators and patient and advocacy groups. In this article, we describe and critique the framework and outline its implementation. Read More

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http://dx.doi.org/10.1111/imj.14861DOI Listing

Is reinfection possible after recovery from COVID-19?

Hong Kong Med J 2020 06 5;26(3):264-265. Epub 2020 Jun 5.

Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.12809/hkmj208601DOI Listing

Are face masks useful for limiting the spread of COVID-19?

Hong Kong Med J 2020 Jun 5;26(3):267-268. Epub 2020 Jun 5.

Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.12809/hkmj208566DOI Listing

A Prediction Tool for the Presence of Ceftriaxone-Resistant Uropathogens upon Hospital Admission.

Antibiotics (Basel) 2020 Jun 10;9(6). Epub 2020 Jun 10.

Department of Pharmacy, National University Health System, Singapore 119228, Singapore.

Antimicrobial resistance among uropathogens is a particularly pressing problem in the Asia-Pacific region. The objectives of this study were to determine the incidence and susceptibility of uropathogens upon hospital admission and to develop a risk-scoring model to predict the presence of ceftriaxone-resistance uropathogens (CrP). This was a retrospective observational cohort study of patients with a positive urine culture within 48 h of presentation at National University Hospital, Singapore between June 2015 and August 2015. Read More

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http://dx.doi.org/10.3390/antibiotics9060316DOI Listing