1,402 results match your criteria Asia-Pacific Journal of Clinical Oncology[Journal]


Safety and effectiveness of transdermal buprenorphine in cancer pain: An observational study in Taiwan (SOOTHE).

Asia Pac J Clin Oncol 2022 May 22. Epub 2022 May 22.

Division of Hematology-Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, and Chang Gung University, Taoyuan, 333, Taiwan.

Aim: Buprenorphine is one of the strongest opioids used for the relief of cancer pain. This study aims to evaluate the real-world clinical experiences of transdermal buprenorphine used in moderate to severe cancer pain in the Asian population.

Methods: This is an open-labeled, multicenter, 4-week observational study. Read More

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Indonesian consensus on systemic therapies for hepatocellular carcinoma.

Asia Pac J Clin Oncol 2022 May 22. Epub 2022 May 22.

Hepatobiliary Division, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Hepatocellular carcinoma (HCC) is a deadly cancer with a rising incidence in the last 20 years. Most patients are diagnosed late when curative treatment is no longer feasible. With the background of chronic liver disease in most patients, the management of HCC becomes more complicated, in which well-preserved liver function is a prerequisite for locoregional or systemic therapies. Read More

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Large variation in radiation therapy fractionation for multiple myeloma in Australia.

Asia Pac J Clin Oncol 2022 May 22. Epub 2022 May 22.

Alfred Health Radiation Oncology, Melbourne, Victoria, Australia.

Aim: To evaluate the patterns of use of different radiation therapy (RT) fractionation for multiple myeloma (MM) bone disease.

Methods: This is a population-based cohort of patients with MM who had RT between 2012 and 2017 as captured in the statewide Victorian Radiotherapy Minimum Data Set in Australia. Data linkage was performed to identify subsets of RT delivered within 3 months of death. Read More

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Local thermal ablative therapies for extracranial oligometastatic disease of non-small-cell lung cancer.

Asia Pac J Clin Oncol 2022 May 22. Epub 2022 May 22.

Department of Oncology, The First Affiliated Hospital of Shandong, First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer, Institute, Jinan, China.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Clinically, 40-50% of patients with NSCLC are found to have systemic metastasis at the initial diagnosis. Meanwhile, 30-75% of patients with lung cancer who have undergone radical surgical resection have local recurrence and distant metastases. Read More

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Safety and efficacy of high-dose cytarabine MEAM therapy and other treatments for auto-peripheral blood stem cell transplantation: A retrospective comparative study.

Asia Pac J Clin Oncol 2022 May 22. Epub 2022 May 22.

Department of Hematology, Nippon Medical School, Tokyo, Japan.

Aim: The MEAM regimen consisting of ranimustine (MCNU), etoposide (ETP), cytarabine (Ara-C), and melphalan (MEL) is widely used before auto-peripheral blood stem cell transplantation (auto-PBSCT) for malignant lymphoma in Japan. The MEAM regimen generally consists of 200-400 mg/m for 4 days, but we decided to increase the dosage of Ara-C from the standard to 2 g/m for 2 days with the aim of increasing drug transferability to the central nervous system. We evaluate the safety and therapeutic efficacy of high-dose Ara-C MEAM therapy. Read More

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Real-time image-guided indocyanine green fluorescence dual-visualization technique to measure the intraoperative resection margin during thoracoscopic segmentectomy.

Asia Pac J Clin Oncol 2022 May 22. Epub 2022 May 22.

Department of Thoracic Surgery, Nanjing Chest Hospital, Nanjing, China.

Aims: The primary goal of thoracoscopic segmentectomy is the complete resection of early pulmonary carcinoma while sparing as much of the normal pulmonary parenchyma as possible, but an obvious trade-off exists between the pulmonary parenchymal preservation and an adequate resection margin. In this clinical trial, we explored a real-time image-guided indocyanine green (ICG) fluorescence dual-visualization technique to confirm the resection margin by improving the intraoperative localization of the pulmonary nodule and identification of the intersegmental boundary line (IBL).

Methods: This study was utilized in 35 patients with a screening-detected lung nodule <2 cm to complete thoracoscopic segmentectomy from December 2020 to June 2021. Read More

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Gail model and fifth edition of ultrasound BI-RADS help predict axillary lymph node metastasis in breast cancer-A multicenter prospective study.

Asia Pac J Clin Oncol 2022 May 20. Epub 2022 May 20.

Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale And Objectives: We aim to assess the performance of the Gail model and the fifth edition of ultrasound BI-RADS (Breast Imaging Reporting and Data System) in breast cancer for predicting axillary lymph node metastasis (ALNM).

Materials And Methods: We prospectively studied 958 female patients with breast cancer between 2018 and 2019 from 35 hospitals in China. Based on B-mode, color Doppler, and elastography, radiologists classified the degree of suspicion based on the fifth edition of BI-RADS. Read More

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Associations of body mass index and weight change with circulating levels of high-sensitivity C-reactive protein, proinflammatory cytokines, and adiponectin among breast cancer survivors.

Asia Pac J Clin Oncol 2022 May 19. Epub 2022 May 19.

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Republic of Korea.

Aim: This study examined the associations of body mass index (BMI) and weight change with inflammatory markers among breast cancer survivors in Korea.

Methods: A total of 495 women were included who had been diagnosed with primary breast cancer and survived for at least 6 months since the surgery. Information on the body weight and height of the participants was collected both at the study enrollment and diagnosis. Read More

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Clinical results of total en bloc spondylectomy using a single posterior approach in spinal metastasis patients: Experiences from Thailand.

Asia Pac J Clin Oncol 2022 May 19. Epub 2022 May 19.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

Aim: To demonstrate a single posterior approach, total en bloc spondylectomy (TES) could be performed safely without preoperative embolization in spinal metastasis patients.

Materials And Methods: Thirteen solitary spinal metastasis patients (five males) underwent single posterior approach TES at the thoracolumbar spine without preoperative embolization from January 2018 to January 2020. The primary sites were the breast (n = 4), hepatocellular carcinoma (n = 2), colon (n = 2), and others (n = 5). Read More

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Opinions and strategies of Australian health professionals on tackling cancer-related financial toxicity: A nationwide survey.

Asia Pac J Clin Oncol 2022 May 19. Epub 2022 May 19.

Behavioural Sciences Unit, Kids Cancer Centre, Sydney Children's Hospital NSW, Sydney, New South Wales, Australia.

Aim: To understand the opinions and current practices of health professionals on the topic of addressing cancer-related financial toxicity among patients.

Methods: A cross-sectional online survey was distributed through Australian clinical oncology professional organizations/networks. The multidisciplinary Clinical Oncology Society of Australia Financial Toxicity Working Group developed 25 questions relating to the frequency and comfort levels of patient-clinician discussions, opinions about their role, strategies used, and barriers to providing solutions for patients. Read More

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Safety and potential increased risk of toxicity of radiotherapy combined immunotherapy strategy.

Asia Pac J Clin Oncol 2022 May 10. Epub 2022 May 10.

Department of radiation oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Accumulating interest has emerged in exploring the toxicity profiles of the combination strategy of radiotherapy (RT) and immune checkpoint inhibitors (ICIs). Much remains unknown regarding safety and the potential increased risk of toxicity of a combined treatment. ICI prolongs survival but can induce immune-related adverse events as well. Read More

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Dynamic changes in systemic immune-inflammation index predict pathological tumor response and overall survival in patients with gastric or gastroesophageal junction cancer receiving neoadjuvant chemotherapy.

Asia Pac J Clin Oncol 2022 May 10. Epub 2022 May 10.

Department of Medical Oncology, Binali Yıldırım University School of Medicine, Erzincan, Turkey.

Aim: Systemic inflammation has been associated with chemoresistance and prognosis in solid tumors. Systemic immune-inflammation index (SII) is a novel marker derived from complete blood count. We investigated whether differences between SIIs measured before and after neoadjuvant chemotherapy (NACT) are associated with tumor regression grade (TRG) and survival in gastric and gastroesophageal junction (GEJ) cancer patients. Read More

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The pathophysiology and current treatments for the subcutaneous panniculitis-like T cell lymphoma: An updated review.

Asia Pac J Clin Oncol 2022 May 4. Epub 2022 May 4.

Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan (ROC).

Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare cutaneous T cell lymphoma, which is indolent in nature but could claim life if not correctly diagnosed and promptly treated. SPTCL is usually presented clinically as painless subcutaneous and erythematous nodules over the trunk or extremities. Active clinical vigilance for these subcutaneous nodules or panniculitis-like lesions is warranted. Read More

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Clinical efficacy and safety of pemetrexed with or without either Bevacizumab or Pembrolizumab in patients with metastatic nonsquamous non-small cell carcinoma.

Asia Pac J Clin Oncol 2022 Apr 20. Epub 2022 Apr 20.

Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China.

Background: Pemetrexed was approved by United States Food and Drug Administration (US FDA) in combination with platinum for the treatment of advanced nonsquamous non-small cell lung carcinoma (NSCLC) and malignant mesothelioma. Bevacizumab and pembrolizumab can be added to chemotherapy for patients with nonsquamous NSCLC with benefits but there has not been any dedicated head-to-head comparison between pembrolizumab-pemetrexed-platinum (PAC) and bevacizumab-pemetrexed-platinum (BAC) on their efficacy and safety.

Methods: This was a retrospective single-center cohort study conducted in Queen Mary Hospital in Hong Kong. Read More

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Prediction of response to radiotherapy in locally advanced carcinoma cervix using multiparametric MRI: A prospective, single-center, longitudinal study.

Asia Pac J Clin Oncol 2022 Apr 18. Epub 2022 Apr 18.

Department of Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Purpose: To evaluate the possible role of a multiparametric magnetic resonance imaging (MRI) and semiquantitative fusion map for the prediction of response to radiotherapy in carcinoma cervix.

Methods: This was a prospective, single-center, longitudinal observational study performed on patients with locally advanced carcinoma cervix. Relative blood flow (rBF), relative blood volume (rBV), and apparent diffusion coefficient (ADC) values were obtained before and after the onset of radiotherapy. Read More

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Pictorial essay on MRI local staging of rectal carcinoma: An easy approach.

Authors:
Wai-Hun Cheah

Asia Pac J Clin Oncol 2022 Apr 18. Epub 2022 Apr 18.

Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Malaysia.

Rectal cancer is common and accounts for more than one-third of colorectal tumors. It is associated with significant morbidity and mortality. Previously computed tomography scan is the key imaging modality in preoperative assessment to detect local invasion and distant metastasis. Read More

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Population pharmacokinetics of doxorubicin: A systematic review.

Asia Pac J Clin Oncol 2022 Apr 12. Epub 2022 Apr 12.

Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.

Because of the high interindividual pharmacokinetic variability, several population pharmacokinetic (PopPK) models of doxorubicin (DOX) were developed to characterize factors influencing such variability. However, significant predictors for DOX pharmacokinetics identified using PopPK models varied across studies. Thus, this review aims to summarize PopPK models of DOX and its metabolites (if any) as well as significant covariates influencing DOX (and its metabolites) pharmacokinetic variability. Read More

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Liver resection for large and huge hepatocellular carcinoma: Predictors of failure, recurrence patterns, and prognoses.

Asia Pac J Clin Oncol 2022 Apr 11. Epub 2022 Apr 11.

Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.

Background: Characteristic symptoms and signs are often absent in patients with hepatocellular carcinoma (HCC). As a result, many patients are not diagnosed until their tumors have grown to large (> 5cm) or huge sizes (> 10cm). Liver resection has traditionally been reserved for patients with small HCC, but more recently it is being used for patients with large and huge tumors. Read More

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A multi-institutional retrospective study of open versus laparoscopic nephroureterectomy focused on the intravesical recurrence.

Asia Pac J Clin Oncol 2022 Apr 11. Epub 2022 Apr 11.

Department of Urology, Kitasato University School of Medicine, Sagamihara, Japan.

Aim: Intravesical recurrence (IVR) after nephroureterectomy for upper tract urothelial carcinoma (UTUC) is relatively frequent, occurring in about 30-50% of patients. The aim of this study was to investigate the differences of the prognosis and IVR between open and laparoscopic surgery and to elucidate the risk factor of IVR.

Patients And Methods: We retrospectively analyzed data from 403 patients with UTUC treated with laparoscopic or open nephroureterectomy at six affiliated hospitals between 1990 and 2015. Read More

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Pretreatment frailty is an independent prognostic factor among elderly patients with B-cell lymphoma undergoing immunochemotherapy: A prospective observational cohort study in Taiwan.

Asia Pac J Clin Oncol 2022 Apr 10. Epub 2022 Apr 10.

Department of Hematology and Oncology, Chang Gung Memorial Hospital at Linkou, and College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background/purpose: Frailty is a common clinical syndrome among the elderly; however, it is frequently neglected in patients with hematological malignancies, especially among the Asian population. This study is aimed to evaluate the prevalence and effect of frailty on survival outcomes in elderly Asian patients with B-cell lymphoma.

Methods: We prospectively enrolled 76 consecutive patients with age ≥ 65 years and newly diagnosed B-cell lymphoma and were receiving immunochemotherapy in a medical center in Taiwan between August 2016 and December 2017. Read More

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Exosome miR-3184-5p inhibits gastric cancer growth by targeting XBP1 to regulate the AKT, STAT3, and IRE1 signalling pathways.

Asia Pac J Clin Oncol 2022 Apr 8. Epub 2022 Apr 8.

Department of Gastrointestinal and Anal Surgery, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, P.R. China.

MicroRNAs can regulate the transcription of protein-coding genes associated with the development and progression of cancer. In this study, we explored the potential diagnostic function of exosome miR-3184-5p in gastric cancer. This exosome was isolated from the blood samples of 150 patients with gastric cancer and 60 healthy participants. Read More

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Real-world evidence of cisplatin versus carboplatin in patients with locally advanced nasopharyngeal carcinoma receiving concurrent chemoradiotherapy: A multicenter analysis.

Asia Pac J Clin Oncol 2022 Apr 8. Epub 2022 Apr 8.

Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Though concurrent chemoradiotherapy (CCRT) with cisplatin remains a standard of care for patients with locally advanced nasopharyngeal carcinoma (LA-NPC), carboplatin has alternatively been used without sufficient supportive evidences. Thus, we evaluated an efficacy and tolerability of carboplatin CCRT compared with cisplatin in LA-NPC patients.

Methods: Patients with LA-NPC treated with CCRT were identified through the Thai multicenter head and neck cancer database. Read More

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Clinical outcomes after positron emission tomography/computed tomography-based image-guided brachytherapy for cervical cancer.

Asia Pac J Clin Oncol 2022 Apr 2. Epub 2022 Apr 2.

Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Introduction: Although positron-emission tomography (PET) plays an integral role in cervix cancer diagnosis, there are limited data on PET-based image-guided brachytherapy (IGBT). We aimed to report the long-term outcomes of PET-based IGBT.

Methods: We reviewed 151 patients treated with definitive radiotherapy (RT), including PET-based IGBT between 2009 and 2018. Read More

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Cancer care clinicians' provision of smoking cessation support: A mixed methods study in New South Wales, Australia.

Asia Pac J Clin Oncol 2022 Mar 31. Epub 2022 Mar 31.

Cancer Institute New South Wales, Alexandria, New South Wales, Australia.

Objectives: Given the importance of supporting cancer patients to quit smoking, we sought to ascertain cancer care clinicians' beliefs and practices regarding providing smoking cessation brief interventions.

Methods: We used a cross-sectional sequential explanatory mixed method design, including a survey of multidisciplinary cancer care clinicians and semistructured interviews.

Results: One hundred and sixty-five cancer care clinicians completed the survey and 21 participated in interviews. Read More

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Neo-adjuvant FOLFIRINOX in borderline resectable and locally advanced pancreatic adenocarcinoma.

Asia Pac J Clin Oncol 2022 Mar 31. Epub 2022 Mar 31.

Department of Internal Medicine, Hematology/Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Surgery and systemic therapy provide the best option for long-term cancer control in localized resectable pancreas cancer. The present study assessed the efficacy and safety of neoadjuvant treatment with FOLFIRINOX in patients with borderline resectable (BR) and locally advanced (LA) pancreas cancer (PDAC).

Methods: This was a prospective noninterventional observational trial of neoadjuvant FOLFIRINOX in BR and LA PDAC. Read More

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Olaparib maintenance monotherapy in Chinese patients with platinum-sensitive relapsed ovarian cancer: China cohort from the phase III SOLO2 trial.

Asia Pac J Clin Oncol 2022 Mar 31. Epub 2022 Mar 31.

Celgene, San Diego, California, USA.

Aim: The phase III SOLO2 global study demonstrated the efficacy and safety of maintenance olaparib, a poly(adenosine diphosphate-ribose) polymerase inhibitor, in platinum-sensitive relapsed ovarian cancer patients with a BRCA mutation. This separate China cohort of SOLO2 investigated the efficacy and safety of maintenance olaparib in Chinese patients.

Methods: Patients received olaparib (300 mg twice daily, oral, tablets) or matched placebo. Read More

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Prevention and management of acneiform rash associated with EGFR inhibitor therapy: A systematic review and meta-analysis.

Asia Pac J Clin Oncol 2022 Mar 29. Epub 2022 Mar 29.

Australian National University Medical School, College of Health and Medicine, The Australian National University, Canberra, Australian Capital Territory, Australia.

Introduction: Epidermal growth factor receptor (EGFR) inhibitors are established therapies for advanced lung, colorectal, and head and neck cancers. They commonly cause acneiform eruptions that affect patient quality of life and may lead to discontinuation of therapy.

Methods: A systematic review and meta-analysis was undertaken to assess strategies for the prevention and reactive management of acneiform rash associated with EGFR inhibitor therapy for advanced lung, colorectal, and head and neck cancers. Read More

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Lag time to diagnosis as a predictor of mortality in children with extraocular retinoblastoma: Experience from a developing country.

Asia Pac J Clin Oncol 2022 Mar 28. Epub 2022 Mar 28.

Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Aim: To define the prevalence of mortality and identify factors associated with mortality in pediatric patients with extraocular retinoblastoma attending the tertiary hospital in Indonesia.

Methods: We retrospectively collected medical records from 2013 to 2019 of patients who were diagnosed with extraocular retinoblastoma. Cox proportional hazard regression analysis with 95% confidence interval (CI) was used to evaluate the association of mortality predictors with patient outcomes (Hazard Ratio [HR], 95% CI) with significance set as p < . Read More

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TNT: Raising more questions than answers?

Asia Pac J Clin Oncol 2022 Mar 24. Epub 2022 Mar 24.

Division of Radiation Oncology, Sir Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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