1,072 results match your criteria Asia-Pacific Journal of Clinical Oncology [Journal]


Validity and reliability of the MD Anderson dysphagia inventory in English and Chinese in head and neck cancer patients.

Asia Pac J Clin Oncol 2020 Jun 23. Epub 2020 Jun 23.

Division of Surgery and Surgical Oncology, Singapore General Hospital/National Cancer Centre, Singapore.

Aims: Patient-reported outcome measures are important in assessing the impact of dysphagia on quality of life. Our aim was to adapt and examine the cultural validity and reliability of a swallowing-related quality of life measure, the MD Anderson Dysphagia Inventory (MDADI), in English and Chinese, with head and neck cancer patients.

Methods: We adapted the MDADI to Chinese through formal forward-backward translation. Read More

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http://dx.doi.org/10.1111/ajco.13384DOI Listing

End of life experiences of patients with advanced cancer in Myanmar: Results from the APPROACH study.

Asia Pac J Clin Oncol 2020 Jun 23. Epub 2020 Jun 23.

Lien Centre for Palliative Care, Duke-NUS Medical School, Singapore, Singapore.

Background: Access to palliative care services is essential for attaining universal health coverage for patients with a terminal cancer. Despite this, many patients with advanced cancer in low-income countries, such as Myanmar, suffer at the end of life (EOL) due to little or no access to palliative care. However, actual evidence on EOL experiences of cancer patients in Myanmar is lacking. Read More

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http://dx.doi.org/10.1111/ajco.13373DOI Listing

Renal immune-related adverse events of immune checkpoint inhibitor.

Asia Pac J Clin Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

The status of immune checkpoint inhibitors (ICPIs) is raising in the treatment of malignancy for their effectiveness. The ICPIs therapy takes the risk of off-target toxicity because of immune system overactivation, including renal toxicity. It was declared that the renal toxicity was rare. Read More

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http://dx.doi.org/10.1111/ajco.13387DOI Listing

Difference in characteristics and outcomes of basaloid squamous cell carcinoma and squamous cell carcinoma, usual type in cervix: A population-based study from SEER 18 database.

Asia Pac J Clin Oncol 2020 Jun 23. Epub 2020 Jun 23.

Pathology Department, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Aim: Cervical basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with little recognition. Our objective was to identify difference in characteristics and outcomes between BSCC and squamous cell carcinoma, usual type (SSC, UT).

Methods: A total of 32 BSCC patients and 6387 SCC, UT patients, diagnosed from 2004 to 2014, were identified using the Surveillance, Epidemiology, and End Results database. Read More

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http://dx.doi.org/10.1111/ajco.13383DOI Listing

Do histopathological features of breast cancer in Australian Indigenous women explain the survival disparity? A two decade long study in the Northern Territory.

Asia Pac J Clin Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Surgery, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Aims: In the Northern Territory (NT) of Australia, Indigenous women have a lower incidence of breast cancer, but a higher mortality than Non-indigenous women. The aim of this study was to describe and compare breast cancer pathological features related to stage and biological aggression between the two groups.

Methods: Subjects were identified by extract from the NT Cancer Registry in two separate cohorts, cohort 1 (1991-2000) and cohort 2 (2001-2010). Read More

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http://dx.doi.org/10.1111/ajco.13377DOI Listing

Genetic aberrations involved in relapse of pediatric acute myeloid leukemia: A literature review.

Asia Pac J Clin Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Oncology, Aga Khan University, Karachi, Pakistan.

Globally, 15-20% of all children diagnosed with leukemia suffer from acute myeloid leukemia (AML), a rapidly progressive, clinically and biologically heterogeneous disease leading to the impaired differentiation of myeloid blast cells. Although 80% of patients achieve complete remission after induction chemotherapy, many relapse, negatively affecting overall out comes. The mechanisms underlying relapse have not been fully elucidated. Read More

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http://dx.doi.org/10.1111/ajco.13367DOI Listing

Advances in immune neoadjuvant/adjuvant therapy-related adverse events of non-small cell lung cancer.

Asia Pac J Clin Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Lung Cancer Surgery, Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.

Lung cancer has been the leading cause of cancer-related death for decades and years. For the patients with early stage non-small cell lung cancer, surgical resection is the mainstay of therapy. Treatment before and after surgery, such as chemotherapy, can bring benefit to these patients, improving the 5 years survival rate by 5% approximately. Read More

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http://dx.doi.org/10.1111/ajco.13378DOI Listing

Age-based efficacy and safety of nivolumab for recurrent or metastatic head and neck squamous cell carcinoma: A multicenter retrospective study.

Asia Pac J Clin Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.

Aim: This study retrospectively investigated the efficacy and safety of nivolumab for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) classified using age <65 years as the cutoff.

Methods: Overall, 88 patients with R/M HNSCC treated with nivolumab were classified into the young group (<65 years; n = 39) and elderly group (≥65 years; n = 49). Efficacy was evaluated using overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and disease control rate (DCR). Read More

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http://dx.doi.org/10.1111/ajco.13374DOI Listing

Exosomal miR-21/Let-7a ratio distinguishes non-small cell lung cancer from benign pulmonary diseases.

Asia Pac J Clin Oncol 2020 Jun 11. Epub 2020 Jun 11.

Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Aim: To assess the exosomal miR-21/Let-7a ratio, a noninvasive method, in distinguishing non-small cell lung cancer (NSCLC) from benign pulmonary diseases.

Methods: The exosomes were extracted from the peripheral blood serum using serum exosomal extraction kit. miR-21 and Let-7a levels were evaluated by quantitative reverse transcription polymerase chain reaction. Read More

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http://dx.doi.org/10.1111/ajco.13343DOI Listing

Gastrostomy dependency trends over 15 years of patients at a large tertiary referral center following the insertion of a prophylactic gastrostomy for chemoradiation for mucosal head and neck cancer.

Asia Pac J Clin Oncol 2020 Jun 9. Epub 2020 Jun 9.

Calvary Mater Newcastle, Hunter Region Mail Centre, New South Wales, Australia.

Aim: The routine use of prophylactic percutaneous endoscopic gastrostomy (PEG) tubes for nutrition support during radical chemoradiation for head and neck cancer has been suggested to result in PEG dependency. This research aimed to determine the rates of gastrostomy dependency at the Calvary Mater Newcastle (CMN) where PEGs are routinely used and to identify potentially modifiable risk factors.

Methods: All patients with head and neck cancer planned for curative chemoradiation with a prophylactic PEG inserted were included in this review. Read More

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http://dx.doi.org/10.1111/ajco.13342DOI Listing

Early salvage radiotherapy in patients with biochemical recurrence after radical prostatectomy: Its impact and optimal candidate.

Asia Pac J Clin Oncol 2020 Jun 9. Epub 2020 Jun 9.

Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Aim: We aimed to identify the optimal candidates for early salvage radiotherapy (SRT) among patients with biochemical recurrence (BCR) after radical prostatectomy (RP).

Methods: This multi-institutional retrospective study included 371 patients treated using SRT after RP. The median (range) PSA level at BCR was 0. Read More

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http://dx.doi.org/10.1111/ajco.13341DOI Listing

Retrospective analysis of hospital admissions due to immune checkpoint inhibitor-induced immune-related adverse events (irAE).

Asia Pac J Clin Oncol 2020 Jun 9. Epub 2020 Jun 9.

Department of Medical Oncology, Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia.

Aim: Hospital admissions secondary to immune-related adverse events (irAE) arising from immune checkpoint inhibitors (ICI) are likely to increase with increasing use of this class of drug. We sought to determine the characteristics and outcomes of hospital admissions due to irAE.

Methods: A retrospective analysis of patients treated with ICI at two tertiary hospitals in Queensland (Australia) was performed. Read More

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http://dx.doi.org/10.1111/ajco.13350DOI Listing

Immune checkpoint inhibitor therapy for cancer patients infected with HIV: A systematic review.

Asia Pac J Clin Oncol 2020 Jun 7. Epub 2020 Jun 7.

Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: Immune checkpoint inhibitor (ICI) therapy represents a breakthrough in cancer treatment. However, clinical trials of ICI have usually excluded people living with HIV (PLWH). The efficacy and safety data of ICI in PLWH is scarce. Read More

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http://dx.doi.org/10.1111/ajco.13320DOI Listing
June 2020
1.058 Impact Factor

Evaluating the predictive factors for anastomotic leakage after total laparoscopic resection with transrectal natural orifice specimen extraction for colorectal cancer.

Asia Pac J Clin Oncol 2020 Jun 7. Epub 2020 Jun 7.

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Natural orifice specimen extraction (NOSE) surgery has been widely implemented in colorectal cancer surgery due to its good short-term efficacy. However, anastomotic leakage (AL) is a serious postoperative complication in colorectal cancer, and the risk factors for this complication after NOSE surgery have rarely been investigated. The aim of this study was to explore the predictive factors for AL after laparoscopic resection with transrectal NOSE for rectal cancer and sigmoid colon cancer. Read More

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http://dx.doi.org/10.1111/ajco.13372DOI Listing

Diagnostic accuracy of MR, CT, and ECT in the differentiation of neoplastic from nonneoplastic spine lesions.

Asia Pac J Clin Oncol 2020 Jun 7. Epub 2020 Jun 7.

Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Aim: To provide guidance for appropriate imaging examinations for diagnosing spinal tumors or tumor-like lesions.

Methods: A total of 121 patients with suspected spinal tumors were included this retrospective study. Each patient underwent ≥2 imaging examinations, including computerized tomography (CT), magnetic resonance (MR), and/or emission computed tomography (ECT). Read More

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http://dx.doi.org/10.1111/ajco.13338DOI Listing

Percutaneous endobiliary radiofrequency ablation and stents in management of hepatocellular carcinoma with bile duct tumor thrombus: Initial single-institution experience.

Asia Pac J Clin Oncol 2020 May 5. Epub 2020 May 5.

Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, 510080, China.

Aim: Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is a rare condition, but it can lead to hepatic failure and is associated with poor prognosis. Treatment for HCC with BDTT remains a challenge. This study aimed to retrospectively evaluate the safety and feasibility of percutaneous endobiliary radiofrequency ablation (EB-RFA) and biliary metal stent placement as an alternative treatment for patients with HCC with BDTT. Read More

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http://dx.doi.org/10.1111/ajco.13330DOI Listing

Trifluridine/tipiracil: A practical guide to its use in the management of refractory metastatic colorectal cancer in Australia.

Asia Pac J Clin Oncol 2020 Apr;16 Suppl 1:3-12

NHMRC Clinical Trials Centre, University of Sydney, NSW, Australia.

Trifluridine/tipiracil is available on the Australian Pharmaceutical Benefits Scheme for the treatment of patients with metastatic colorectal cancer (mCRC) previously treated with, or not considered candidates for, fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-vascular endothelial growth factor agents and anti-epidermal growth factor receptor agents. This article reviews trifluridine/tipiracil clinical data and presents practical information on its use in the management of refractory mCRC in Australia. Whereas the primary mechanism of action of fluoropyrimidines such as fluorouracil (5-FU) and capecitabine is enzyme inhibition of nucleotide synthesis, trifluridine/tipiracil primarily acts by incorporation into DNA, resulting in DNA dysfunction. Read More

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http://dx.doi.org/10.1111/ajco.13336DOI Listing
April 2020
1.058 Impact Factor

Strategies for patient with cancer during COVID-19 pandemic.

Asia Pac J Clin Oncol 2020 Apr 20. Epub 2020 Apr 20.

Department of Surgical oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014.

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http://dx.doi.org/10.1111/ajco.13363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264569PMC

Mainstream consent programs for genetic counseling in cancer patients: A systematic review.

Asia Pac J Clin Oncol 2020 Apr 20. Epub 2020 Apr 20.

Medical Oncology, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.

As demand for germline genetic testing for cancer patients increases, novel methods of genetic counseling are required. One such method is the mainstream consent pathway, whereby a member of the oncology team (rather than a genetic specialist) is responsible for counseling, consenting, and arranging genetic testing for cancer patients. We systematically reviewed the literature for evidence evaluating mainstream pathways for patients with breast, ovarian, colorectal, and prostate cancer. Read More

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http://dx.doi.org/10.1111/ajco.13334DOI Listing

Recommendations to improve the clinical adoption of NGS-based cancer diagnostics in Singapore.

Asia Pac J Clin Oncol 2020 Apr 16. Epub 2020 Apr 16.

Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.

Next-generation sequencing (NGS)-based diagnostics have demonstrated clinical utility in predicting improved survival benefits with targeted treatment in certain cancer types, and positive cost-benefit in several healthcare systems. However, clinical adoption in Singapore remains low despite commercial availability of these diagnostics. This expert opinion review examines the key challenges to the clinical adoption of NGS-based diagnostics in Singapore, provides recommendations on impactful initiatives to improve adoption, and also offers practical guidance on specific cancer types in which NGS-based diagnostics are appropriate for use in Singapore. Read More

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http://dx.doi.org/10.1111/ajco.13339DOI Listing

The prognostic value of the prognostic nutritional index in patients with metastatic colorectal cancer.

Asia Pac J Clin Oncol 2020 Apr 16. Epub 2020 Apr 16.

Department of Medical Oncology, University of Health Sciences Ankara City Hospital, Ankara, Turkey.

Objective: The prognostic nutritional index (PNI) has been shown to be prognostic value for many types of cancer of the gastrointestinal system. However, there are limited data on its value for metastatic colorectal cancer (mCRC). This study aimed to evaluate the prognostic value of PNI in newly diagnosed mCRC patients. Read More

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http://dx.doi.org/10.1111/ajco.13328DOI Listing
April 2020
1.058 Impact Factor

Why do delays to diagnosis and treatment of lung cancer occur? A mixed methods study of insights from Australian clinicians.

Asia Pac J Clin Oncol 2020 Apr 16. Epub 2020 Apr 16.

Sydney Medical School, University of Sydney, New South Wales, Australia.

Aims: Delays in lung cancer diagnosis and treatment can impact survival. We explored reasons for delays experienced by patients with lung cancer to identify themes and strategies for improvement.

Methods: We used national timeframe recommendations and standardized definitions to identify General Practitioners and specialists caring for 34 patients who experienced delays in our previous Medicare data linkage study. Read More

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http://dx.doi.org/10.1111/ajco.13335DOI Listing

A consensus statement on the use of biosimilar medicines in hematology in Australia.

Asia Pac J Clin Oncol 2020 Apr 14. Epub 2020 Apr 14.

Monash Haematology, Monash Health, Clayton, Victoria, Australia.

Despite their availability for over a decade, the exact nature of biosimilar medicines is still poorly understood with paucity of clear treatment guidelines for their use in clinical practice in Australia. Although hematologists have had experience with biosimilars in the setting of supportive care, with the approval of the first biosimilar rituximab in hematological malignancies, it is important to revisit this topic. To inform the use of biosimilar medicines in clinical practice, we have developed a consensus statement from an Expert Panel of Australian hematologists, oncologists, and cancer pharmacists. Read More

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http://dx.doi.org/10.1111/ajco.13337DOI Listing

The survival benefit of radiotherapy in localized primary adult rhabdomyosarcoma.

Asia Pac J Clin Oncol 2020 Apr 14. Epub 2020 Apr 14.

Department of Radiation Oncology, The Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China.

Aim: To evaluate the role of radiotherapy (RT) in the treatment of localized primary adult rhabdomyosarcoma (RMS).

Methods: This retrospective study identified 62 consecutive adult patients with localized primary RMS from January 2000 and July 2016. Local failure-free survival (LFFS), distant metastasis-free survival (DMFS) and overall survival (OS) were analyzed by the Kaplan-Meier method. Read More

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http://dx.doi.org/10.1111/ajco.13331DOI Listing

Psychosocial effects of appearance changes due to cancer treatment and needs for information and supportive care in Japanese cancer patients.

Asia Pac J Clin Oncol 2020 Apr 14. Epub 2020 Apr 14.

Department of Medical Oncology, Kindai University Faculty of Medicine, Ōsakasayama, Osaka, Japan.

Purpose: Cancer treatment can alter patient appearance, leading to psychological, social, and behavioral issues. This study aimed to investigate distress and difficulties related to appearance concerns in Japanese cancer patients and to identify information and support needs among them.

Methods: We conducted a questionnaire survey using the Derriford Appearance Scale 59 (DAS59) among cancer patients with a prior history of chemotherapy, molecular targeted therapy, or immunotherapy, who were recruited from the Departments of Medical Oncology and Psychosomatic Medicine, Kindai University Hospital. Read More

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http://dx.doi.org/10.1111/ajco.13333DOI Listing

Preventive effect of daikenchuto, a traditional Japanese herbal medicine, on onset of ileus after gynecological surgery for malignant tumors.

Asia Pac J Clin Oncol 2020 Mar 27. Epub 2020 Mar 27.

Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Background: Postoperative ileus is a major complication of abdominal surgical procedures. The purpose of this study was to investigate preventive effect of daikenchuto (DKT) on onset of ileus in patients who received gynecological surgery for malignant tumors.

Methods: A total of 904 patients who received gynecological surgery for malignant tumors by opening retroperitoneum along with retroperitoneal lymph node dissection during a period between 2004 and 2018 were included in this retrospective study. Read More

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http://dx.doi.org/10.1111/ajco.13329DOI Listing

The role of immunosuppressive agents in the management of severe and refractory immune-related adverse events.

Asia Pac J Clin Oncol 2020 Mar 24. Epub 2020 Mar 24.

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

The advent of immune checkpoint inhibitors has improved survival in some types of cancer and brought promising prospects to cancer immunotherapy. Despite their clinical benefits, significant off-target toxicities resulting from the immune system activation have been observed, namely immune-related adverse events (irAEs), which pose to clinicians a new challenge of optimal management. With steroids being the mainstay of current management of irAEs, immunosuppressive agents are especially indicated for severe or steroid-refractory cases, based on current immunopathophysiological knowledge and on extrapolations of treatment options for primary autoimmune disorders. Read More

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http://dx.doi.org/10.1111/ajco.13332DOI Listing
March 2020
1.058 Impact Factor

Comparison of safety of loop ileostomy and loop transverse colostomy for low-lying rectal cancer patients undergoing anterior resection: A retrospective, single institution, propensity score-matched study.

Asia Pac J Clin Oncol 2020 Mar 21. Epub 2020 Mar 21.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: This study was to compare the prevalence of stoma-related complications and stoma reversal perioperative complications of patients with low-lying rectal cancer who received preventative loop ileostomy and those who underwent loop transverse colostomy.

Methods: This retrospective single-center study analyzed the clinicopathologic and surgical data of 288 patients with pathologically proven primary rectal cancer who underwent anterior resection with either preventative loop ileostomy (n = 82) or loop transverse colostomy. To achieve comparability of a propensity score matching method was used to match patients from each group in a 1:2 ratio. Read More

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http://dx.doi.org/10.1111/ajco.13322DOI Listing
March 2020
1.058 Impact Factor

The rationale and toxicity of combined cranial radiotherapy and immune checkpoint inhibitors in non-small cell lung cancer.

Asia Pac J Clin Oncol 2020 Mar 4. Epub 2020 Mar 4.

Department of Radiation Oncology, Peking University Third Hospital, Beijing, China.

Cranial radiation therapy (CRT) remains to be the foundation stone of the management of brain metastases in non-small cell lung cancer (NSCLC). Nevertheless, the care of NSCLC, recently, has been remarkably reshaped by the immune checkpoint inhibitors (ICIs), such as programmed death protein-1 and programmed death ligand-1 inhibitors, which even showed some efficacy in brain metastases. Furthermore, radiotherapy, traditionally regarded as a therapy via localized cytotoxicity, recently was reported to trigger a systemic immune response, thus probably enhancing the antitumor effect of ICIs. Read More

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http://dx.doi.org/10.1111/ajco.13327DOI Listing

Colorectal cancer in the United States and a review of its heterogeneity among Asian American subgroups.

Asia Pac J Clin Oncol 2020 Mar 4. Epub 2020 Mar 4.

Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Colorectal cancer is the third most common cancer in the United States. Established risk factors include older age, unhealthy lifestyle (high consumptions of red/preserved meat, low consumptions of fruit and vegetables, smoking, high alcohol consumption, and lack of physical activities), personal and family medical histories and low socioeconomic status (low insurance coverage, education and income). Asian American subgroups vary significantly in terms of culture, socioeconomic status, and health behaviors, yet most registries and researches aggregate all Asian Americans as one group. Read More

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http://dx.doi.org/10.1111/ajco.13324DOI Listing

The efficacy of axitinib as a first-line treatment for metastatic renal cell carcinoma.

Asia Pac J Clin Oncol 2020 Mar 4. Epub 2020 Mar 4.

Department of Urology, Jichi Medical University, Tochigi, Japan.

Aim: To evaluate predictive factors which associated with oncological outcomes to first-line axitinib for metastatic renal cell carcinoma (mRCC).

Methods: A retrospective chart review was conducted patients who had been treated with axitinib as first-line therapy for the treatment of mRCC from September 2013 to February 2018. Axitinib was given by single daily oral administration at a dose of 10 mg, which was reduced according to adverse events (AEs). Read More

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http://dx.doi.org/10.1111/ajco.13323DOI Listing

Cardiovascular immune-related adverse events: Evaluation, diagnosis and management.

Authors:
Yingxian Liu Wei Wu

Asia Pac J Clin Oncol 2020 Mar 4. Epub 2020 Mar 4.

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.

Cardiotoxicities are associated with immune checkpoint inhibitor (ICI) therapy. Recent case series and retrospective studies have shown that cardiac immune-related adverse events (irAEs) are rare but potentially fatal complications of immunotherapy, with various underlying risk factors such as combinations of different ICIs. High mortality rates and overreactive inflammation have been observed with ICI-associated cardiotoxicities, highlighting the necessity of baseline and serial evaluations and the identification and management of cardiac irAEs as early as possible. Read More

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http://dx.doi.org/10.1111/ajco.13326DOI Listing

Neutrophil count kinetics during the first cycle of chemotherapy predicts the outcome of patients with locally advanced or metastatic pancreatic cancer.

Asia Pac J Clin Oncol 2020 Mar 4. Epub 2020 Mar 4.

Department of Oncology, Ospedale Civile di Sanremo, Sanremo, Italy.

Background: Neutrophil count reduction after chemotherapy has been related with longer survival of patients with metastatic pancreatic adenocarcinoma, but there is not a standardized measurement for this phenomenon.

Methods: Some parameters related to the change in neutrophil count between the first and the second cycle of chemotherapy or between the baseline count and the nadir have been evaluated among patients with advanced pancreatic cancer at a single institution. A Cox regression model was built which included, in addition to the common prognostic variables, some variables related to the change of the neutrophil count after chemotherapy. Read More

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http://dx.doi.org/10.1111/ajco.13325DOI Listing

Comparison of S-1 plus oxaliplatin (SOX) and capecitabine plus oxaliplatin (XELOX) as adjuvant chemotherapies for stage II and III gastric cancer after D2 resection: A single-center retrospective study.

Asia Pac J Clin Oncol 2020 Jun 20;16(3):180-186. Epub 2020 Feb 20.

National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Capecitabine plus oxaliplatin (XELOX) as adjuvant therapy for gastric cancer (GC) reduces cancer recurrence and improves survival. S-1 plus oxaliplatin (SOX) is well-tolerated and effective against advanced GC, and also be used widely in adjuvant treatment. However, data comparing SOX and XELOX as adjuvant treatments are lacking. Read More

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http://dx.doi.org/10.1111/ajco.13321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318315PMC

Recognition and management of the gastrointestinal and hepatic immune-related adverse events.

Asia Pac J Clin Oncol 2020 Jun 20;16(3):95-102. Epub 2020 Feb 20.

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China.

Immunotherapy is revolutionizing the treatment paradigm for a broad spectrum of malignancies. However, the immune checkpoint inhibitors also cause a unique set of toxicities. In the digestive system, this has consisted for the most part as colitis and hepatotoxicity, but also include less-common manifestations. Read More

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http://dx.doi.org/10.1111/ajco.13317DOI Listing
June 2020
1.058 Impact Factor

Tissue factor pathway inhibitor 2 suppresses the growth of thyroid cancer cells through by induction of apoptosis.

Asia Pac J Clin Oncol 2020 Feb 11. Epub 2020 Feb 11.

Clinical Medical College, Research Centre of Biomedical Technology, Yancheng Institute of Health Sciences, No. 283 Jiefang South Road, Yancheng, Jiangsu, 224005, P.R. China.

Background: Tissue factor pathway inhibitor 2 (TFPI-2) has been recently identified as a tumor suppressor gene in several human cancers, whereas its role in thyroid cancer has been unclear.

Methods: The TFPI-2 protein level in thyroid cancer tissues and cell lines (8305C and B-CPAP) were examined using immunohistochemistry and immunoblotting. The TFPI-2 promoter methylation was examined using methylation-specific polymerase chain reaction (MSP). Read More

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http://dx.doi.org/10.1111/ajco.13298DOI Listing
February 2020
1.058 Impact Factor

Neoadjuvant chemoradiotherapy might provide survival benefit in patients with stage IIIb/IIIc locally advanced rectal cancer: A retrospective single-institution study with propensity score-matched comparative analysis.

Asia Pac J Clin Oncol 2020 Jun 7;16(3):142-149. Epub 2020 Feb 7.

Department of General Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Neoadjuvant chemoradiotherapy (NACRT) and total mesorectal excision (TME) are standard treatments of stage II/III locally advanced rectal cancer (LARC), currently. Here, we evaluated the oncological outcomes in LARC patients treated with NACRT compared to TME alone, and determined whether tumor regression grade (TRG) and pathologic response after NACRT was related to prognosis.

Methods: This is a retrospective comparison of 358 LARC patients treated with either TME alone (non-NACRT group, n = 173) or NACRT plus TME (NACRT group, n = 185) during 2003-2013. Read More

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http://dx.doi.org/10.1111/ajco.13306DOI Listing
June 2020
1.058 Impact Factor

Addition of short course radiotherapy in newly diagnosed locally advanced rectal cancers with distant metastasis.

Asia Pac J Clin Oncol 2020 Feb 7. Epub 2020 Feb 7.

Departments of Surgical Oncology (Colorectal diseases), Tata Memorial Centre, Mumbai, India.

Aim: To study the outcomes of patients presenting with locally advanced rectal cancers with distant metastasis (mLARC), treated with short course radiotherapy (SCRT).

Method: Between May 2012 and August 2015, 70 patients diagnosed with mLARC, treated with SCRT (25 Gy/5#) and three to six cycles of CAPOX chemotherapy (CT), were assessed for surgical feasibility for the primary and metastatic sites.

Results: Sixty-five patients could complete the planned SCRT and three to six cycles of CT. Read More

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http://dx.doi.org/10.1111/ajco.13305DOI Listing
February 2020
1.058 Impact Factor

Tumor volume and sphericity as predictors of local control after stereotactic radiosurgery for limited number (1-4) brain metastases from nonsmall cell lung cancer.

Asia Pac J Clin Oncol 2020 Jun 7;16(3):165-171. Epub 2020 Feb 7.

Department of Radiation Oncology, Inha University Hospital, Inha University of Medicine, Inchon, Korea.

Aim: This study aims to evaluate the usage of brain metastases (BM) tumor volume and sphericity as prognostic factors in local control (LC) after stereotactic radiosurgery (SRS) for limited number (1-4) BM from nonsmall cell lung cancer (NSCLC).

Methods: We retrospectively reviewed 80 patients, with 141 BM, who were treated with SRS from 2012 to 2017. Local failure was defined as an increase in lesion size after SRS. Read More

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http://dx.doi.org/10.1111/ajco.13309DOI Listing

National and subnational trends in incidence and mortality of lung cancer in Iran from 1990 to 2016.

Asia Pac J Clin Oncol 2020 Jun 7;16(3):129-136. Epub 2020 Feb 7.

Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Aim: Lung cancer is the most common cancer in incidence and mortality worldwide. The aim of the current study was to present population-based estimates of lung cancer epidemiology by gender and age group at national and subnational levels during the 27-year period of 1990-2016.

Methods: This study was part of the NASBOD project (National and Subnational Burden of Disease, Injuries, and Risk Factors). Read More

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http://dx.doi.org/10.1111/ajco.13303DOI Listing

Incidental gallbladder cancer after laparoscopic cholecystectomy: incidence, management, and prognosis.

Asia Pac J Clin Oncol 2020 Jun 7;16(3):158-164. Epub 2020 Feb 7.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Aims: Although incidental gallbladder cancer (IGBC) diagnosed after laparoscopic cholecystectomy (LC) is not rare, its incidence, management, and prognosis are still unclear and controversial. The present study aimed to increase the understanding of IGBC after LC in the medical community.

Methods: Patients with IGBC treated at our institution between January 2001 and December 2018 were enrolled. Read More

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http://dx.doi.org/10.1111/ajco.13308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317500PMC

TP53 mutations are associated with very complex karyotype and suggest poor prognosis in newly diagnosed myelodysplastic syndrome patients with monosomal karyotype.

Asia Pac J Clin Oncol 2020 Jun 7;16(3):172-179. Epub 2020 Feb 7.

Myelodysplastic Syndromes Diagnosis and Therapy Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Aim: The aim of this study was to evaluate the clinical and molecular characteristics of myelodysplastic syndrome (MDS) patients with monosomal karyotype (MK).

Methods: Eighty MDS patients with MK diagnosed between January 2010 and December 2018 were included in the retrospective study. Seventy-three had complex karyotype (CK) and 46 had very CK (vCK, ≥ 5 abnormalities). Read More

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http://dx.doi.org/10.1111/ajco.13316DOI Listing

Increasing Tim-3+CD244+, Tim-3+CD57+, and Tim-3+PD-1+ T cells in patients with acute myeloid leukemia.

Asia Pac J Clin Oncol 2020 Jun 7;16(3):137-141. Epub 2020 Feb 7.

Institute of Hematology, School of Medicine, Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.

Aim: To characterize the distribution of T cell immunoglobulin mucin-domain-containing-3 (Tim-3) within the exhausted T cells in patients with newly diagnosed acute myeloid leukemia (AML) and AML in complete remission.

Methods: Tim-3 expression and coexpression with PD-1, CD244, and CD57 in CD3+, CD4+, and CD8+T cells were analyzed by multicolored fluorescent flow cytometry in peripheral blood from 28 newly diagnosed, untreated AML patient and 12 cases with AML in complete remission, 23 healthy individuals served as control.

Results: Increasing Tim-3+CD244+ and Tim-3+CD57+ in CD3+, CD4+, and CD8+ T cells were found in AML and AML-CR groups in comparison with healthy controls. Read More

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http://dx.doi.org/10.1111/ajco.13304DOI Listing

The INTERNET STUDY: A phase II study of everolimus in patients with fluorodeoxyglucose ( F) positron-emission tomography positive intermediate grade pancreatic neuroendocrine tumors.

Asia Pac J Clin Oncol 2020 Jun 7;16(3):150-157. Epub 2020 Feb 7.

Neuroendocrine Unit, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Aims: This multicenter phase II trial evaluates the efficacy of everolimus in poor prognosis grade 2 (G2) pancreatic neuroendocrine tumors (PNETs), defined by 2-[fluorine-18]fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) avidity. FDG-PET avidity in NETs is associated with a significantly higher risk of death, outperforming Ki-67 index or liver metastases as a poor prognostic factor. We hypothesized that everolimus has efficacy in patients with FDG-PET-avid G2 PNETs and prospectively evaluated progression-free survival (PFS) and response in the first-line setting. Read More

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http://dx.doi.org/10.1111/ajco.13307DOI Listing

Diagnostic roles of HOX transcript antisense intergenic RNA in cancer.

Asia Pac J Clin Oncol 2020 Feb 7. Epub 2020 Feb 7.

Department of Epidemiology, Binzhou Medical University, Yantai, ShanDong, P.R. China.

HOX transcript antisense intergenic RNA (HOTAIR) is considered a diagnostic biomarker for cancer; however, results of previous studies on HOTAIR are inconsistent. In this meta-analysis, we aimed to investigate the role of HOTAIR in cancer diagnosis. Medline, PubMed, Embase, Ovid, Web of Science and Cochrane databases were searched for relevant literature up to May 2019. Read More

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http://dx.doi.org/10.1111/ajco.13300DOI Listing
February 2020

Experiences of barriers and facilitators to establishing and sustaining radiotherapy services in low- and middle-income countries: A qualitative study.

Asia Pac J Clin Oncol 2020 Apr 7;16(2):e74-e85. Epub 2020 Feb 7.

IMPACCT (Improving Palliative, Aged and Chronic Care through Clinical Research and Translation), Faculty of Health, University of Technology Sydney, New South Wales, Australia.

Aims: The factors contributing to the establishment of high-quality radiotherapy services in low- and middle-income countries (LMICs) are poorly understood. The aim was to identify and describe barriers and facilitators to establishing and sustaining high-quality and accessible radiotherapy services in LMICs based on the experience of successful and unsuccessful attempts.

Methods: An exploratory-descriptive qualitative study using semistructured telephone interviews was undertaken. Read More

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http://dx.doi.org/10.1111/ajco.13310DOI Listing

The mechanism of propofol in cancer development: An updated review.

Asia Pac J Clin Oncol 2020 Apr 22;16(2):e3-e11. Epub 2020 Jan 22.

Institute of Basic Medical Sciences & Shaanxi Key Laboratory of Brain Disorders, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Xi'an Medical University, Xi'an, China.

Cancer is a key cause of death worldwide. Despite the development of radiotherapy, chemotherapy and even immunotherapy, surgery remains the standard treatment for cancer patients. Recently, many studies have shown that propofol, a commonly used anesthetic drug, can affect the prognosis of cancer. Read More

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http://dx.doi.org/10.1111/ajco.13301DOI Listing
April 2020
1.058 Impact Factor

Impact of migrancy on cancer clinical trial participation: Factors associated with approach and consent in Australian-born versus migrant groups.

Asia Pac J Clin Oncol 2020 Jun 19;16(3):115-122. Epub 2020 Jan 19.

The Psycho-oncology Co-operative Research Group, University of Sydney, Sydney, New South Wales, Australia.

Background/aims: This study compared rates of clinical trial participation and perceived adequacy of information provided prior to consent in migrant and Australian-born cancer patients, and explored factors associated with being approached and agreeing to participate.

Methods: We utilized data from a larger cross-sectional survey assessing disparities in patient-reported outcomes in Chinese, Arabic, or Greek migrant versus English-speaking Australian-born cancer patients. Participants completed a questionnaire eliciting demographic and disease details, communication challenges, whether invited and consented to a clinical trial, and if so, adequacy of information received. Read More

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http://dx.doi.org/10.1111/ajco.13290DOI Listing

Male Breast Cancer in Australia.

Asia Pac J Clin Oncol 2020 Jan 19. Epub 2020 Jan 19.

Breast Cancer Research Centre-WA, Western Australia, Australia.

Aims: Male breast cancer is rare and treatment recommendations are based on female breast cancer guidelines. We analyzed an Australian dataset of patients with early breast cancer (including ductal carcinoma in situ, DCIS) for demographic, pathological and treatment information. The primary objective was to compare treatment delivery for males versus females. Read More

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http://dx.doi.org/10.1111/ajco.13299DOI Listing
January 2020

Cost-effectiveness of icotinib versus whole-brain irradiation with or without chemotherapy in EGFR-mutant NSCLC patients with brain metastases.

Asia Pac J Clin Oncol 2020 Jan 19. Epub 2020 Jan 19.

The Cancer Center of the First Hospital of Jilin University, Changchun, P. R. China.

Purpose: Nonsmall cell lung cancer (NSCLC) patients with brain metastases (BM) have a poor prognosis. Despite the traditional methods including radiotherapy and chemotherapy, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) might benefit patients on survival and quality of life. We investigated the cost-effectiveness of icotinib compared with whole-brain irradiation (WBI) with or without chemotherapy for NSCLC patients with BM. Read More

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http://dx.doi.org/10.1111/ajco.13291DOI Listing
January 2020
1.058 Impact Factor