4,359 results match your criteria Asia-Pacific Journal of Clinical Oncology [Journal]


Complete genome analysis demonstrates multiple introductions of enterovirus 71 and coxsackievirus A16 recombinant strains into Thailand during the past decade.

Emerg Microbes Infect 2018 Dec 14;7(1):214. Epub 2018 Dec 14.

Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon, Pathom, 73170, Thailand.

Hand, foot, and mouth disease (HFMD) caused by enteroviruses remains a public health threat, particularly in the Asia-Pacific region during the past two decades. Moreover, the introduction of multiple subgenotypes and the emergence of recombinant viruses is of epidemiological importance. Based on either the full genome or VP1 sequences, 32 enteroviruses (30 from HFMD patients, 1 from an encephalitic patient, and 1 from an asymptomatic contact case) isolated in Thailand between 2006 and 2014 were identified as 25 enterovirus 71 (EV71) isolates (comprising 20 B5, 1 C2, 2 C4a, and 2 C4b subgenotypes) and 7 coxsackievirus A16 (CA16) isolates (comprising 6 B1a and 1 B1b subgenotypes). Read More

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December 2018
1 Read

Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013-2015: inpatients and outpatients.

Int J Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Hand, foot and mouth disease (HFMD) has been associated with large outbreaks among young children, including severe illness and fatality, in the Asia-Pacific Region since 1997. Severe illness is often associated with enterovirus A71 (EV-A71). Vietnam experienced a large sustained outbreak of 200. Read More

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December 2018
1 Read

Mortality and losses to follow-up among adolescents living with HIV in the IeDEA global cohort collaboration.

J Int AIDS Soc 2018 Dec;21(12):e25215

TREAT Asia/amfAR, The Foundation for AIDS Research, Bangkok, Thailand.

Introduction: We assessed mortality and losses to follow-up (LTFU) during adolescence in routine care settings in the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium.

Methods: Cohorts in the Asia-Pacific, the Caribbean, Central, and South America, and sub-Saharan Africa (Central, East, Southern, West) contributed data, and included adolescents living with HIV (ALHIV) enrolled from January 2003 and aged 10 to 19 years (period of adolescence) while under care up to database closure (June 2016). Follow-up started at age 10 years or the first clinic visit, whichever was later. Read More

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December 2018
1 Read

Transcatheter Valve Replacement in Asia Pacific: Current Practice and Perspectives.

J Am Coll Cardiol 2018 Dec;72(24):3189-3199

Interventional Cardiology Unit, GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy. Electronic address:

Although the field of transcatheter therapies for valvular heart disease (VHD) is continuously expanding in western countries, uptake of this treatment in Asia has been slow, mainly due to the high cost of devices, need for specific training programs, and lack of specialized heart teams and dedicated structures. Moreover, anatomic considerations of the Asian population, such as smaller aorta and peripheral vessel size, high prevalence of bicuspid aortic valves, high calcium burden of stenotic aortic valve leaflets, low coronary ostia, and high prevalence of rheumatic etiology, might raise concerns about feasibility, risk of procedural complications, prosthesis durability, and long-term outcomes after transcatheter treatment of VHD. Asia Pacific and China's medical communities and manufacturer companies are setting up to address this unmet clinical need. Read More

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December 2018

Increased Mortality Associated with Higher Pre-Dialysis Serum Sodium Variability: Results of the International MONitoring Dialysis Outcome Initiative.

Am J Nephrol 2018 Dec 13;49(1):1-10. Epub 2018 Dec 13.

Renal Research Institute, New York, New York, USA.

Background: Low serum sodium (SNa) is associated with an increased mortality in chronic hemodialysis (HD) patients. Dialysis patients are thought to have an individual pre-dialysis SNa set-point, yet there is evidence for variability of pre-dialysis SNa in individual patient. In this study, we explored the association of several SNa variability metrics with all-cause mortality in a large patient population from the international MONitoring Dialysis Outcomes (MONDO) Initiative. Read More

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December 2018

Inclusion of mental health in global economic development.

BJPsych Int 2018 Nov;15(4):74-76

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

The APEC Mental Health Roadmap has a vision to strengthen mental health and reduce the economic impact of mental illness in the Asia Pacific. To facilitate its implementation, the APEC Digital Hub will heighten exchange and dissemination of best practices in Asia Pacific mental health partnerships, and increase multi-sectoral recognition to invest in mental health to support economic growth. Read More

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November 2018

Mental health and integration in Asia Pacific.

Authors:
Chee H Ng

BJPsych Int 2018 Nov;15(4):76-79

Department of Psychiatry, University of Melbourne, Australia; email

This brief report examines the extent to which community-based treatment and integration support are provided for people living with mental illness across 15 selected Asia-Pacific economies. Some of the key findings are discussed in light of the diversity of economies and cultural contexts. Read More

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November 2018

Molecular epidemiology and clinical features of hand, foot and mouth disease in northern Thailand in 2016: a prospective cohort study.

BMC Infect Dis 2018 Dec 6;18(1):630. Epub 2018 Dec 6.

School of Health Science Research, Mae Fah Luang University, 333 Mo.1 Tasud Subdistrict, Muang District, Chiang Rai, Chiang Rai Province, 57100, Thailand.

Background: Hand, foot and mouth disease (HFMD) is a major communicable disease in children ≤6 years old, particularly in several countries in the Asia-Pacific Region, including Thailand. HFMD impacts public health and the economy, especially in northern Thailand.

Methods: A prospective cohort study was conducted to estimate the incidence rate and to identify the serotype and clinical features of HFMD among children in northern Thailand. Read More

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December 2018

Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study.

PLoS One 2018 12;13(12):e0208796. Epub 2018 Dec 12.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.

Background: The number of patients with diabetes is increasing particularly in Asia-Pacific region. Many of them are treated with antidiabetics. As the basis of the studies on the benefit and harm of antidiabetic drugs in the region, the information on patterns of market penetration of new classes of antidiabetic medications is important in providing context for subsequent research and analyzing and interpreting results. Read More

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December 2018
3.234 Impact Factor

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Nat Microbiol 2018 Dec 10. Epub 2018 Dec 10.

Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell entry. The isolated structures of EV71 and SCARB2 are known, but how they interact to initiate infection is not. Read More

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December 2018

Malignancies in adults living with HIV in Asia.

J Acquir Immune Defic Syndr 2018 Nov 29. Epub 2018 Nov 29.

Taipei Veterans General Hospital, Taipei, Taiwan.

BackgroundHaematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence, risk factors for, and outcomes of haematological and non-haematological malignancies in PLHIV in Asia.MethodsIncidence of malignancy after cohort enrolment was evaluated. Read More

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November 2018
1 Read
4.556 Impact Factor

Early and late virologic failure following virologic suppression in HIV-infected Asian children and adolescents.

J Acquir Immune Defic Syndr 2018 Nov 20. Epub 2018 Nov 20.

Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Background: Virologic failure is a major threat to maintaining effective combination antiretroviral therapy, especially for children in need of lifelong treatment. With efforts to expand access to HIV viral load testing, our understanding of pediatric virologic failure is evolving.

Setting: An Asian cohort in16 pediatric HIV services across six countries. Read More

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November 2018

The importance of sleep for governmental sectors, general population and industry - Asia-Pacific Economic Cooperation (APEC) Sleep Technology Agenda.

Sleep Med Rev 2018 Nov 9. Epub 2018 Nov 9.

Office of International Cooperation, Ministry of Health and Welfare, Taipei, Taiwan.

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November 2018
1 Read
8.513 Impact Factor

Determination of the minimum protective dose of a glycoprotein-G-deficient infectious laryngotracheitis virus vaccine delivered via eye-drop to week-old chickens.

PLoS One 2018 6;13(12):e0207611. Epub 2018 Dec 6.

Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Infectious laryngotracheitis (ILT) is an upper respiratory tract disease of chickens that is caused by infectious laryngotracheitis virus (ILTV), an alphaherpesvirus. This disease causes significant economic loses in poultry industries worldwide. Despite widespread use of commercial live attenuated vaccines, many poultry industries continue to experience outbreaks of disease caused by ILTV. Read More

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December 2018
3 Reads

Air Pollution in the Asia-Pacific Region: A Joint APSR/ATS Perspective.

Am J Respir Crit Care Med 2018 Dec 3. Epub 2018 Dec 3.

The Prince Charles Hospital, Metro North Hospital and Health Service, Brisbane, Queensland, Australia.

Industrial and technological developments have led to major economic growth in the Asia Pacific, but an unintended consequence has been an increase in illness associated with air pollution. Given the complementary mandates of the Asian Pacific Society of Respirology and the American Thoracic Society, the organizations partnered to focus on the need for clean air. A task force was assembled with individuals who have expertise in the effects of air pollution or the development of professional society policy statements. Read More

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December 2018
1 Read

Fatal shark attacks on divers in Australia, 1960-2017.

Authors:
John Lippmann

Diving Hyperb Med 2018 Dec;48(4):224-228

Divers Alert Network Asia-Pacific Foundation, Ashburton, Victoria, Australia.

Aim: The aim of this study was to identify the number, location and characteristics associated with fatal shark attacks on divers in Australian waters from 1960 to 2017, inclusive.

Methods: Searches were made of the Divers Alert Network Asia-Pacific Diving Mortality Database; the International Shark Attack File website; the Australian Shark Attack File and the Global Shark Attack File to identify cases of fatal shark attacks on divers in Australia. In addition, a systematic search of published medical and sporting literature was conducted to identify relevant reports. Read More

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December 2018
1 Read

IeDEA-WHO Research-Policy Collaboration: contributing real-world evidence to HIV progress reporting and guideline development.

J Virus Erad 2018 Nov 15;4(Suppl 2):9-15. Epub 2018 Nov 15.

Vanderbilt University School of Medicine, Nashville, TN, USA.

Partnerships between researchers and policymakers can improve uptake and integration of scientific evidence. This article describes the research-policy partnership between the International epidemiology Databases to Evaluate AIDS (IeDEA) ( www.iedea. Read More

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November 2018

Significance and positive predictive values of mammographic findings in the Asia-Pacific region: a single-centre study in Taiwan.

Clin Radiol 2018 Dec 1. Epub 2018 Dec 1.

Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Aim: To report positive predictive values (PPVs) of mammographic findings (MFs) of a screening cohort in Taiwan with a view to providing radiologists around the world with adequate information for assessing MFs before recommending biopsy for Asian women.

Materials And Methods: Between January 2014 and June 2017, 18,449 women received screening mammography at Tri-Service General Hospital (TSGH). Of these women, 1,622 exhibited specific MFs, namely mass (n=518), microcalcification (n=668), focal asymmetry (FA; n=462), and architectural distortion (AD; n=117). Read More

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December 2018
1 Read

Cause and consequence of loss in vaccine trust.

Hum Vaccin Immunother 2018 Dec 4. Epub 2018 Dec 4.

a College of Medicine , University of the Philippines-Manila.

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December 2018
1 Read

Variation, sources and historical trend of black carbon in Beijing, China based on ground observation and MERRA-2 reanalysis data.

Environ Pollut 2018 Nov 23;245:853-863. Epub 2018 Nov 23.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Beijing Normal University, Beijing, 100875, China; Center of Atmospheric Environmental Studies, Beijing Normal University, Beijing, 100875, China.

Based on the ground-measurements and MERRA-2 (Modern-Era Retrospective Analysis for Research and Applications, Version 2) reanalysis data, the temporal-spatial variation of black carbon (BC) in Beijing and the affecting factors were investigated. According to the ground-measured BC concentration in November months of 2014, 2015 and 2016, the before-heating period in November 2014 showed the lowest BC concentration as a result of the efficient emission controls for the Asia-Pacific Economic Cooperation (APEC) meeting. Except for November 2014, the BC mass concentration during the heating periods was notably lower than the before-heating periods in November 2015 and 2016. Read More

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November 2018
4.143 Impact Factor

Loops Rescue the No-Boundary Proposal.

Phys Rev Lett 2018 Nov;121(20):201301

Asia Pacific Center for Theoretical Physics, Pohang 37673, South Korea.

New and nontrivial properties of off-shell instantons in loop quantum cosmology show that dynamical signature change naturally cures recently observed problems in the semiclassical path integral of quantum gravity. If left unsolved, these problems would doom any theory of smooth initial conditions of the Universe. The no-boundary proposal, as a specific example of such a theory, is rescued by loops, presenting a rare instance of a fruitful confluence of different approaches to quantum cosmology. Read More

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November 2018
1 Read

Small Magnetic Charges and Monopoles in Nonassociative Quantum Mechanics.

Phys Rev Lett 2018 Nov;121(20):201602

Department of Physics, The Pennsylvania State University, 104 Davey Lab, University Park, Pennsylvania 16802, USA.

Weak magnetic monopoles with a continuum of charges less than the minimum implied by Dirac's quantization condition may be possible in nonassociative quantum mechanics. If a weakly magnetically charged proton in a hydrogen atom perturbs the standard energy spectrum only slightly, magnetic charges could have escaped detection. Testing this hypothesis requires entirely new methods to compute energy spectra in nonassociative quantum mechanics. Read More

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November 2018

Infant and young child feeding practices and nutritional status in Bhutan.

Matern Child Nutr 2018 Nov;14 Suppl 4:e12762

Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

In South Asia, childhood undernutrition persists while overweight is increasing. Internationally recommended infant and young child feeding (IYCF) practices promote healthy nutritional status; however, little is known about IYCF in Bhutan, investigated here using 2015 National Nutrition Survey data. WHO/UNICEF IYCF indicators, anthropometry and household socio-economic status were available for 441 children <24 months. Read More

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November 2018

Clinical trials of intervertebral disc regeneration: current status and future developments.

Int Orthop 2018 Nov 29. Epub 2018 Nov 29.

Departments of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Intervertebral disc (IVD) degeneration (IDD) is considered as one of the major causes for low back pain (LBP). However, conventional surgical approaches for treating LBP do not aim to counter the degeneration. Biological interventions have been investigated with an attempt to regenerate the IVD by restoring its matrices and cell activities. Read More

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November 2018
1 Read

The economic returns of ending the AIDS epidemic as a public health threat.

Health Policy 2018 Nov 22. Epub 2018 Nov 22.

Avenir Health, 655 Winding Brook Drive, Glastonbury, CT 06033, USA.

Background: In 2016, countries agreed on a Fast-Track strategy to "end the AIDS epidemic by 2030". The treatment and prevention components of the Fast-Track strategy aim to markedly reduce new HIV infections, AIDS-related deaths and HIV-related discrimination. This study assesses the economic returns of this ambitious strategy. Read More

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November 2018
2 Reads

Hepatitis B virus relapse rates in chronic hepatitis B patients who discontinue either entecavir or tenofovir.

Aliment Pharmacol Ther 2018 Nov 28. Epub 2018 Nov 28.

Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are first-line long-term monotherapy for treatment of chronic hepatitis B (CHB) infection. High virological relapse rates are found after cessation of either ETV or TDF in CHB patients.

Aim: To compare hepatitis B virus (HBV) relapse rates in CHB patients without cirrhosis who discontinued ETV or TDF. Read More

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November 2018
2 Reads

My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed.

J Headache Pain 2018 Nov 27;19(1):115. Epub 2018 Nov 27.

Novartis Pharma AG, Basel, Switzerland.

Background: Migraine is associated with many debilitating symptoms that affect daily functioning. My Migraine Voice is a large global cross-sectional study aimed at understanding the full burden and impact of migraine directly from patients suffering from ≥4 monthly migraine days (MMDs) with a history of prophylactic treatment failure.

Methods: This study was conducted worldwide (31 countries across North and South Americas, Europe, the Middle East and Northern Africa, and the Asia-Pacific region) using an online survey administered to adults with migraine who reported ≥4 MMDs in the 3 months preceding survey administration, with pre-specified criteria of 90% having used preventive migraine treatment (80% with history of ≥1 treatment failure). Read More

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November 2018
2 Reads

Fish Consumption and Stroke Risk: A Meta-Analysis of Prospective Cohort Studies.

J Stroke Cerebrovasc Dis 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurosurgery, Nanchong Central Hospital (The Second Clinical College of North Sichuan Medical College), Nanchong, Sichuan, China.

Background: Inconsistent results of the association between fish consumption and stroke risk have been indicated in previous epidemiological studies. Therefore, we performed a meta-analysis of prospective cohort studies to estimate the impact of fish consumption on stroke risk.

Methods: The PubMed and EMBASE databases were searched through a computer search. Read More

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November 2018
6 Reads

Infant Feeding Guidelines for the Asia Pacific Region.

Asia Pac J Public Health 2018 Nov 23:1010539518809823. Epub 2018 Nov 23.

13 University of Colombo, Colombo, Sri Lanka.

Good nutrition for infants, during the first 1000 days from conception, is one of the most important determinants of a healthy long life. Breastfeeding is the most important component of infant nutrition and reduces morbidity and mortality. With the changes to the climate currently occurring, issues of nutrition and food supply are only going to increase in importance. Read More

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November 2018
4 Reads
1.111 Impact Factor

Evolving role of pharmaceutical physicians in medical evidence and education.

Adv Med Educ Pract 2018 2;9:777-790. Epub 2018 Nov 2.

Global Medical Affairs, Asia-Pacific Region, Pfizer Australia, West Ryde, NSW, Australia.

The role of pharmaceutical physicians who are the experts working in pharmaceutical companies has progressed over the last few decades, from supervising research and development (R&D) studies and/or providing support to marketing teams to serving an independent critical function. In this review, we focus on pharmaceutical physicians serving medical affairs functions in the pharmaceutical industry. Historically, members of the medical affairs team mainly provided a bridge between commercial teams and the R&D sector and between the organization and external stakeholders. Read More

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November 2018

Psychometric validation of the Perceived Deficits Questionnaire-Depression (PDQ-D) instrument in US and UK respondents with major depressive disorder.

Neuropsychiatr Dis Treat 2018 29;14:2861-2877. Epub 2018 Oct 29.

Global Outcomes Research, Lundbeck SAS, Issy-les-Moulineaux, France.

Background: Although depression and cognitive dysfunction are connected, limited tools exist to capture the patient's perspective on cognitive dysfunction and its impact on major depressive disorder (MDD). We report results of a psychometric validation of the Perceived Deficits Questionnaire-Depression (PDQ-D), a self-report measure of cognitive dysfunction for use in MDD.

Methods: A non-interventional, prospective, panel-recruited, online survey was conducted using the PDQ-D in adults with and without MDD in the US and UK. Read More

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October 2018
4 Reads

Frequency and Antimicrobial Susceptibility of Bacterial Isolates from Patients Hospitalised with Community-Acquired Skin and Skin Structure Infection in Europe, Asia, and Latin America.

J Glob Antimicrob Resist 2018 Nov 17. Epub 2018 Nov 17.

JMI Laboratories, North Liberty, Iowa, USA.

Background: Ceftaroline fosamil is approved for the treatment of acute bacterial skin and skin structure infections (ABSSSI), including those caused by methicillin-resistant Staphylococcus aureus (MRSA). We evaluated the frequency and antimicrobial susceptibility of organisms isolated from patients hospitalised with community-acquired (CA) SSSI in Europe (EUR), the Asia-Pacific region (APAC), and Latin America (LATAM).

Methods: Isolates (n=5,120) were consecutively collected from patients hospitalised with CA-SSSI in 2014-2016 from 63 medical centres in 41 nations, stratified as: western EUR (W-EUR; 20 centres/10 nations), eastern EUR and the Mediterranean region (E-EUR; 16 centres/12 nations), APAC (16 centres/10 nations), and LATAM (11 centres/9 nations). Read More

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November 2018

Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism.

Zoo Biol 2018 Nov 20;37(6):440-451. Epub 2018 Nov 20.

Department of Biology, National Museum of Marine Biology and Aquarium, Pingtung, Taiwan.

Integrating multifactor blood analysis is a key step toward a precise diagnosis of the health status of marine mammals. Variations in the circulating lipid profile reflect changes in the metabolism and physiology of an individual. To demonstrate the practicability of lipid profiling for physiological assessment, the phosphorylcholine-containing lipids in the plasma of long-term managed beluga whales (Delphinapterus leucas) were profiled using a lipidomics methodology. Read More

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November 2018
3 Reads

The prevalence of Coxiella burnetii shedding in dairy goats at the time of parturition in an endemically infected enterprise and associated milk yield losses.

BMC Vet Res 2018 Nov 20;14(1):353. Epub 2018 Nov 20.

Asia-Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Corner Park Drive and Flemington Road, Parkville Victoria, 3010, Australia.

Background: This was a panel study of the prevalence of C. burnetii infection in does in an endemic dairy goat enterprise in Victoria, Australia. Our first objective was to determine the prevalence of does shedding C. Read More

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November 2018

Adenoma detection rates in colonoscopies for positive fecal immunochemical tests versus direct screening colonoscopies.

Gastrointest Endosc 2018 Nov 16. Epub 2018 Nov 16.

Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong. Electronic address:

Background And Aim: Recent guidelines propose higher adenoma detection rate (ADR) benchmarks for colonoscopies performed for positive fecal immunochemical tests (FIT), but this is based on low quality evidence. We aimed to compare ADR, advanced ADR (AADR), and number of adenoma per colonoscopy (APC) in direct screening colonoscopy (DSC) versus FIT positive colonoscopy (FITC) in a multicenter Asia Pacific cohort to justify differential targets.

Methods: Asymptomatic average-risk subjects at or above 50 years of age who underwent screening colonoscopy directly or as follow-up for positive OC-Sensor FIT were identified from eight sites across the Asia Pacific region. Read More

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November 2018
4 Reads

Meteorological factors and its association with hand, foot and mouth disease in Southeast and East Asia areas: a meta-analysis.

Epidemiol Infect 2018 Nov 19:1-18. Epub 2018 Nov 19.

Department of Epidemiology and Health Statistics,School of Public Health, Southeast University,Nanjing (210009),China.

Since the late 1990s, hand, foot and mouth disease (HFMD) has become a common health problem that mostly affects children and infants in Southeast and East Asia. Global climate change is considered to be one of the major risk factors for HFMD. This study aimed to assess the correlation between meteorological factors and HFMD in the Asia-Pacific region. Read More

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November 2018
5 Reads
2.535 Impact Factor

Development and validation of a scoring system for advanced colorectal neoplasm in young Korean subjects less than age 50 years.

Intest Res 2018 Nov 20. Epub 2018 Nov 20.

Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background/aims: Colorectal cancer incidence among patients aged ≤50 years is increasing. This study aimed to develop and validate an advanced colorectal neoplasm (ACRN) screening model for young adults aged <50 years in Korea.

Methods: This retrospective cross-sectional study included 59,575 consecutive asymptomatic Koreans who underwent screening colonoscopy between 2003 and 2012 at a single comprehensive health care center. Read More

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November 2018
6 Reads

Definition of treatment-resistant depression - Asia Pacific perspectives.

J Affect Disord 2018 Nov 5;245:626-636. Epub 2018 Nov 5.

Medical University of Vienna, Vienna, Austria.

Background: The lack of uniformity in the definition of treatment resistant depression (TRD) within the Asia-Pacific (APAC) region may have implications for patient management. We aimed to characterize the most commonly used TRD definition in selected APAC countries.

Methods: A systematic literature review of TRD definitions in APAC countries was conducted in Medline and Embase (2010-2016) and conference proceedings (2014 and 2016). Read More

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November 2018
2 Reads

Future of Public Health Training: What Are the Challenges? What Might the Solutions Look Like?

Asia Pac J Public Health 2018 Nov 16:1010539518810555. Epub 2018 Nov 16.

1 Queensland University of Technology, Brisbane, Queensland, Australia.

The Asia-Pacific region has rapidly changing health needs. This reshaping of health priorities is directly affecting current and future public health education. This brief review focuses on foundational public health skills including epidemiology, biostatistics, and health informatics. Read More

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November 2018
5 Reads

Robust visualization of middle cerebral artery main trunk by enhanced acceleration-selective arterial spin labeling (eAccASL) for intracranial MRA.

Magn Reson Med 2018 Nov 15. Epub 2018 Nov 15.

Philips Healthcare BIU MR, Asia Pacific, Tokyo, Japan.

Purpose: A new sequence for intracranial MRA is developed, named enhanced acceleration-selective arterial spin labeling (eAccASL), to improve main artery visualization at middle cerebral artery (MCA). The aim of this study is to assess the visualization improvement using eAccASL, compared with the previously developed AccASL.

Methods: eAccASL and AccASL were performed in 8 healthy volunteers and images were compared between the 2 sequences. Read More

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November 2018
2 Reads

Enterovirus-A71 Infection Activates Human Immune Responses and Induces Pathological Changes in Humanized Mice.

J Virol 2018 Nov 14. Epub 2018 Nov 14.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore

Since the discovery of enterovirus-A71 (EV-A71) half a century ago, it has caused large-scale outbreaks of hand-foot-and-mouth disease worldwide, in particular in the Asia-Pacific region, causing a great concern of public health and economic burden. Detailed mechanisms on the modulation of immune responses after EV-A71 infection have not been fully known, and the lack of appropriate models hinders the development of promising vaccines and drugs. In the present study, NOD- (NSG) mice with human immune system (humanized mice) at the age of four-week-old were found to be susceptible to a human isolate of EV-A71 infection. Read More

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November 2018
13 Reads

What are the financial barriers to medical care among the poor, the sick and the disabled in the Special Administrative Region of China?

PLoS One 2018 14;13(11):e0205794. Epub 2018 Nov 14.

Department of Social Work, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.

Although Hong Kong is one of the richest cities in the world and has some of the best health outcomes such as long life expectancy, little is known about the people who are unable to access healthcare due to lack of financial means. Cross-sectional data from a sample of 2,233 participants aged 18 or above was collected from the first wave of the "Trends and Implications of Poverty and Social Disadvantages in Hong Kong" survey. Socio-demographic factors, lifestyle factors, and physical and mental health conditions associated with people who were unable to seek medical services due to lack of financial means in the past year were examined using forward stepwise logistic regression analyses. Read More

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November 2018
4 Reads
3.230 Impact Factor

Ertapenem non-susceptibility and independent predictors of the carbapenemase production among the Enterobacteriaceae isolates causing intra-abdominal infections in the Asia-Pacific region: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART).

Infect Drug Resist 2018 17;11:1881-1891. Epub 2018 Oct 17.

Departments of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan,

Objectives: This study investigated the prevalence rates of carbapenemase positivity, antibiotic susceptibility, and independent predictors of carbapenemase producers among the Enterobacteriaceae isolates recovered from patients with intra-abdominal infections (IAI) in the Asia-Pacific region between 2008 and 2014.

Materials And Methods: Multiplex PCR was used for the detection of specific β-lactamases, while the broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of antibiotics among the IAI-related Enterobacteriaceae isolates. We studied the abovementioned parameters in 484 ertapenem-non-susceptible (Erta-NS) isolates and explored the independent predictors of carbapenemase-producing Enterobacteriaceae (CPE) isolates. Read More

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October 2018
5 Reads

Pathogenic significance of hemorrhagic pneumonia in hematologic malignancy patients with Stenotrophomonas maltophilia bacteremia: clinical and microbiological analysis.

Eur J Clin Microbiol Infect Dis 2018 Nov 12. Epub 2018 Nov 12.

Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Hemorrhagic pneumonia (HP) is known as the clinical manifestation of Stenotrophomonas maltophilia infection, while catheter-related blood stream infection (CRBSI) is the common clinical presentation of S. maltophilia bacteremia (SMB). The purpose of this study is to evaluate the risk factors for mortality in hematologic malignancy patients with SMB and to analyze clinical and microbiological characteristics of HP associated with SMB and CRBSI. Read More

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November 2018
2 Reads

Development and application of high-resolution melting analysis for the classification of infectious laryngotracheitis virus strains and detection of recombinant progeny.

Arch Virol 2018 Nov 12. Epub 2018 Nov 12.

Asia-Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.

Live attenuated vaccines against infectious laryngotracheitis virus (ILTV) are widely used in the poultry industry to control disease and help prevent economic losses. Molecular epidemiological studies of currently circulating strains of ILTV within poultry flocks in Australia have demonstrated the presence of highly virulent viruses generated by genomic recombination events between vaccine strains. In this study, high-resolution melting (HRM) analysis was used to develop a tool to classify ILTV isolates and to investigate ILTV recombination. Read More

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November 2018
4 Reads

Pharmaceutical Policy Reforms to Regulate Drug Prices in Asia Pacific Region: The Case of Australia, China, India, Malaysia, New Zealand, and South Korea.

Value Health Reg Issues 2018 Nov 6;18:18-23. Epub 2018 Nov 6.

University of Huddersfield, Huddersfield, UK.

Medicine price directly affects affordability and access to medicines particularly in countries where a major portion of pharmaceutical spending is through out-of-pocket payment, such as in the Asia Pacific region. We have undertaken a detailed appraisal of the pharmaceutical policy reforms to regulate drug prices in 3 developed (Australia, New Zealand, and South Korea) and 3 emerging (China, India, and Malaysia) economies of the Asia Pacific region. Despite continuous efforts by the authorities in adopting a wide range of reformatory pharmaceutical pricing policies to ensure affordability of medicines, these policies may not be optimal where drug prices were not lowered as expected (eg, in Korea). Read More

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November 2018

Nutritional status and risk factors for stunting in preschool children in Bhutan.

Matern Child Nutr 2018 Nov 9;14 Suppl 4:e12653. Epub 2018 Nov 9.

Center for Human Nutrition, Johns Hopkins School of Public Health, Baltimore, MD.

Childhood malnutrition remains endemic in South Asia, although the burden varies by country. We examined the anthropometric status and risk factors for malnutrition among children aged 0-59 months through the 2015 National Nutrition Survey in Bhutan. We assessed in 1,506 children nutritional status (by z-scores of height-for-age [HAZ], weight-for-height [WHZ], and weight-for-age [WAZ]), estimating prevalence, adjusted for survey design, of stunting, wasting, underweight, and overweight (<-2 for HAZ, WHZ, and WAZ and >2 for WHZ). Read More

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November 2018
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A qualitative study of quality of life domains and subdomains relevant to patients with spondyloarthritis.

Int J Rheum Dis 2018 Nov 8. Epub 2018 Nov 8.

Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore.

Aims: To identify quality of life (QoL) domains and subdomains relevant to patients with different spondyloarthritis (SpA) subtypes in Singapore, and to assess how identified QoL domains and subdomains map onto currently used patient-reported outcome measures (PROMs).

Methods: Nine focus group discussions (FGDs), including two previously conducted FGDs from the Updating the Psoriatic Arthritis Core Domain Set Study, were conducted with patients with SpA in Singapore. The FGDs were organized by SpA subtype and language spoken. Read More

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November 2018
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