365 results match your criteria Asia Pacific allergy[Journal]


Asia Pacific Association of Allergy Asthma and Clinical Immunology and Workshop on Eosinophils in Allergy and Related Diseases.

Asia Pac Allergy 2020 Apr 28;10(2):e23. Epub 2020 Apr 28.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan.

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http://dx.doi.org/10.5415/apallergy.2020.10.e23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203433PMC

Preface to the Proceedings of the 33rd Workshop on Eosinophils in Allergy and Related Diseases 2019 (WEA 2019).

Authors:
Hiroyuki Nagase

Asia Pac Allergy 2020 Apr 27;10(2):e22. Epub 2020 Apr 27.

Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.5415/apallergy.2020.10.e22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203430PMC

Activation of inflammation and resolution pathways of lipid mediators in synovial fluid from patients with severe rheumatoid arthritis compared with severe osteoarthritis.

Asia Pac Allergy 2020 Apr 27;10(2):e21. Epub 2020 Apr 27.

Allergy and Immunology Research Project Team, Research Institute of Medical Science, Nihon University School of Medicine, Tokyo, Japan.

Background: The upregulation of the cyclooxygenase and lipoxygenase pathways of arachidonic acid is thought to be involved in the development of rheumatoid arthritis. Recently, the presence of specialized pro-resolving lipid mediators in synovial tissues from patients with osteoarthritis has been reported.

Objective: To clarify the quantitative and qualitative changes in lipid mediators in the synovium of severe rheumatoid arthritis patients, we compared the profiles of lipid mediators in synovial fluid obtained from patients with severe rheumatoid arthritis and from those with severe osteoarthritis. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203435PMC

DsRNA induction of microRNA-155 disrupt tight junction barrier by modulating claudins.

Asia Pac Allergy 2020 Apr 27;10(2):e20. Epub 2020 Apr 27.

Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

Background: The impaired barrier function of the airway epithelium due to RNA virus infection is closely related to the development and exacerbation of allergic airway inflammation.

Objective: In this study, we investigated the roles of microRNAs on the mechanisms of double-stranded RNA (dsRNA)-induced epithelial barrier dysfunction.

Methods: 16HBE14o- human bronchial epithelial cells were grown to confluence on Transwell inserts and exposed to poly-I:C. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203438PMC

Repetitive instructions at short intervals contribute to the improvement of inhalation technique.

Asia Pac Allergy 2020 Apr 27;10(2):e19. Epub 2020 Apr 27.

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Background: Inhaled medicines are key drugs for the treatment of asthma or chronic obstructive pulmonary disease. However, the variety of inhaler devices and complicated inhalation procedures have created confusion among patients, affecting their correct understanding of inhalation. Recent studies reported that up to 80% of patients made technical errors in inhalation and emphasized the necessity for patient education. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203431PMC

Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation.

Asia Pac Allergy 2020 Apr 27;10(2):e18. Epub 2020 Apr 27.

Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Background: Environmental tobacco smoke (ETS) exposure is recognized as a risk factor for the development of various respiratory diseases.

Objective: In this study, the effect of ETS on allergen-immunized and allergen-specific Th2 cell-transferred murine eosinophilic inflammation models and that of cigarette smoke extract (CSE) and nicotine on allergen-induced Th2 cell proliferation and interleukin (IL)-4 production were investigated.

Methods: Ovalbumin (OVA)-immunized and OVA-specific Th2 cell-transferred BALB/c mice were exposed to ETS and were challenged with OVA. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203434PMC

Relationship between airway inflammation and airflow limitation in elderly asthmatics.

Asia Pac Allergy 2020 Apr 23;10(2):e17. Epub 2020 Apr 23.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan.

Background: The prevalence of asthma in elderly population has been increasing. Previous studies have demonstrated clinical characteristics of elderly asthmatics (EA). However, little is known regarding the influence of immunological change on the physiological status of EA. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203439PMC

Clinical and endoscopic characteristics of eosinophilic esophagitis in Japan: a case-control study.

Asia Pac Allergy 2020 Apr 23;10(2):e16. Epub 2020 Apr 23.

Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, Okayama, Japan.

Background: Eosinophilic esophagitis (EoE) is an allergy-associated clinicopathologic condition gaining an increasing amount of recognition in various areas of the world. While the clinical definition and characteristics may differ depending on country and region, sufficient studies have not yet been performed in Japan.

Objective: To assess the prevalence of EoE among the Japanese population and the clinical features associated with the disease. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203441PMC

Effects of β2-adrenergic agonists on house dust mite-induced adhesion, superoxide anion generation, and degranulation of human eosinophils.

Asia Pac Allergy 2020 Apr 22;10(2):e15. Epub 2020 Apr 22.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan.

Background: Even in subjects who are not sensitized to house dust mite (HDM), allergic symptoms can be clinically aggravated by exposure to dust. We previously reported that (), an important HDM, or Der f 1, a major allergen of , induced the effector functions of eosinophils, which may be an important mechanism for HDM-induced symptoms in nonsensitized patients. In a clinical setting, β2-adrenergic agonists, such as salbutamol and formoterol, are used for the treatment of asthma attacks or exacerbation to release the airway obstruction. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203437PMC

Mechanisms of eosinophilic inflammation.

Asia Pac Allergy 2020 Apr 16;10(2):e14. Epub 2020 Apr 16.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan.

Eosinophils play roles in the pathogenesis of various diseases. In order to accumulate within sites of inflammation, eosinophils must adhere to, and migrate across the microvasculature. These processes are largely controlled by type 2-immune responses; interleukin (IL)-4 and IL-13 induce the expression of endothelial adhesion molecule vascular cell adhesion molecule-1 (VCAM-1), a representative adhesive ligand for eosinophils, while also stimulating generations of CC chemokines from structural cells, including epithelial cells. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203432PMC

Three cases of severe adolescent asthma treated with mepolizumab: lung function trajectories.

Asia Pac Allergy 2020 Apr 10;10(2):e13. Epub 2020 Apr 10.

Department of Clinical Research, National Hospital Organization Mie National Hospital, Tsu, Japan.

Real-world experience with mepolizumab for pediatric asthma is still limited. We report 3 patients who were treated with mepolizumab for severe adolescent asthma. Two patients, a 12-year-old boy and a 14-year-old girl, responded well to mepolizumab and showed apparent improvement in lung function from a downward trend over time before treatment. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203436PMC

Relationship between changes in the 7-day urticaria activity score after treatment with omalizumab and the responsiveness of basophils to FcεRI stimulation in patients with chronic spontaneous urticaria.

Asia Pac Allergy 2020 Apr 10;10(2):e12. Epub 2020 Apr 10.

Allergy and Immunology Research Project Team, Research Institute of Medical Science, Nihon University School of Medicine, Tokyo, Japan.

Background: About one-half of all patients with chronic spontaneous urticaria have low or less reactivity of the basophils to FcεRI stimulation. However, the differences in the clinical characteristics between patients who show normal and attenuated basophil reactivities to FcεRI stimulation are still unclear. Furthermore, it also remains unknown as to what factors induce the poor reactivity of basophils to FcεRI stimulation. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203440PMC

White Paper 2020 on climate change, air pollution, and biodiversity in Asia-Pacific and impact on allergic diseases.

Asia Pac Allergy 2020 Jan 7;10(1):e11. Epub 2020 Feb 7.

Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of Medicine, Seoul, Korea.

Air pollution, climate change, and reduced biodiversity are major threats to human health with detrimental effects on a variety of chronic noncommunicable diseases in particular respiratory and cardiovascular diseases. The extent of air pollution both outdoor and indoor air pollution and climate change including global warming is increasing-to alarming proportions particularly in the developing world especially rapidly industrializing countries worldwide. In recent years, Asia has experienced rapid economic growth and a deteriorating environment and increase in allergic diseases to epidemic proportions. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016319PMC
January 2020

The 10th Anniversary of .

Authors:
Yoon-Seok Chang

Asia Pac Allergy 2020 Jan 31;10(1):e10. Epub 2020 Jan 31.

Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

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http://dx.doi.org/10.5415/apallergy.2020.10.e10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016318PMC
January 2020

Association between fruit and vegetable allergies and pollen-food allergy syndrome in Japanese children: a multicenter cross-sectional case series.

Asia Pac Allergy 2020 Jan 31;10(1):e9. Epub 2020 Jan 31.

Departmant of Pediatrics, Osaka Habikino Medical Center, Habikino, Japan.

Background: Recently, the prevalence of food allergies during childhood is increasing, with fruits being common allergens. However, data on allergens that cause fruit and vegetable allergies and pollen-food allergy syndrome (PFAS) in childhood are relatively few. This study aimed to examine the allergens in fruit and vegetable allergies in pediatric patients and to determine the association between fruit and vegetable allergies and PFAS. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016322PMC
January 2020

Drug hypersensitivity reactions in Asia: regional issues and challenges.

Asia Pac Allergy 2020 Jan 30;10(1):e8. Epub 2020 Jan 30.

Department of Pediatrics, Nippon Medical School, Tokyo, Japan.

There are geographical, regional, and ethnic differences in the phenotypes and endotypes of patients with drug hypersensitivity reactions (DHRs) in different parts of the world. In Asia, aspects of drug hypersensitivity of regional importance include IgE-mediated allergies and T-cell-mediated reactions, including severe cutaneous adverse reactions (SCARs), to beta-lactam antibiotics, antituberculous drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and radiocontrast agents. Delabeling of low-risk penicillin allergy using direct oral provocation tests without skin tests have been found to be useful where the drug plausibility of the index reaction is low. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016324PMC
January 2020

Fractional exhaled nitric oxide and forced expiratory volume in 1 second/forced vital capacity have predictive value of asthma exacerbation in Korean school children.

Asia Pac Allergy 2020 Jan 28;10(1):e7. Epub 2020 Jan 28.

Department of Pediatrics, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.

Background: The incidence of asthma exacerbation (AE) and the predictive value of spirometry and fractional exhaled nitric oxide (FeNO) in school children have not been evaluated.

Objective: We sought to evaluate the efficacy of spirometry measurement and FeNO monitoring for predicting AE in school children in the Cheongju area in Korea.

Methods: With parental agreement, we studied 170 students aged 7-12 years. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016316PMC
January 2020

A 5-year retrospective review of children with peanut allergy in the largest paediatric hospital in Singapore.

Asia Pac Allergy 2020 Jan 28;10(1):e6. Epub 2020 Jan 28.

Allergy Service, Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore.

Background: The prevalence of peanut allergy (PA) among children has increased significantly over the past decade. Even though the prevalence of PA in Singapore is considered low, peanut is the top trigger for food-induced anaphylaxis in Singaporean children.

Objective: To describe the demographic characteristics and clinical features of children with PA. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016321PMC
January 2020

Differences in omega-5-gliadin allergy: East versus West.

Asia Pac Allergy 2020 Jan 26;10(1):e5. Epub 2020 Jan 26.

Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.

Background: Omega-5-gliadin (O5G) allergy, also known as wheat-dependent exercise-induced anaphylaxis, is commonly reported in the Western, but not Asian, populations. Although significant differences in O5G allergy presentation across different populations are likely but there have been no previous reports on this important topic.

Objective: To report on the prevalence and characteristics of O5G allergy in Hong Kong (HK) compared with the United Kingdom (UK). Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016325PMC
January 2020

Banana anaphylaxis in Thailand: case series.

Asia Pac Allergy 2020 Jan 26;10(1):e4. Epub 2020 Jan 26.

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Banana fruit has been recognized as an important food allergen source. Nowadays banana hypersensitivity had been reported more frequently with various presentations from oral allergy syndrome to anaphylaxis.

Objective: This study aims to describe the pattern of banana hypersensitivity and the sensitivity of diagnostic test. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016326PMC
January 2020

Forced oscillation technique as a predictor for loss of control in asthmatic children.

Asia Pac Allergy 2020 Jan 17;10(1):e3. Epub 2020 Jan 17.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: A reliable objective tool using as a predictor of asthma control status could assist asthma management.

Objective: To find the parameters of forced oscillation technique (FOT) as predictors for the future loss of asthma symptom control.

Methods: Children with well-controlled asthma symptom, aged 6-12 years, were recruited for a 12-week prospective study. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016320PMC
January 2020

Altered T cell and monocyte subsets in prolonged immune reconstitution inflammatory syndrome related with DRESS (drug reaction with eosinophilia and systemic symptoms).

Asia Pac Allergy 2020 Jan 17;10(1):e2. Epub 2020 Jan 17.

Laboratory of Mucosal Immunology in Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe cutaneous adverse reaction involving various internal organs. Flare-ups after recovery from the initial presentation of DRESS are caused by relapse of drug-induced T-cell-mediated reactions. However, the specific underlying mechanism is unclear. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016323PMC
January 2020

Anaphylaxis diagnosis and management in the Emergency Department of a tertiary hospital in the Philippines.

Asia Pac Allergy 2020 Jan 13;10(1):e1. Epub 2020 Jan 13.

The Medical City Hospital, Pasig, the Philippines.

Background: In the Emergency Department (ED), diagnosis and management of anaphylaxis are challenging with at least 50% of anaphylaxis episodes misdiagnosed when the diagnostic criteria of current guidelines are not used.

Objective: Objective of our study was to assess anaphylaxis diagnosis and management in patients presenting to the ED.

Methods: Retrospective chart review conducted on patients presenting to The Medical City Hospital ED, the Philippines from 2013-2015 was done. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016317PMC
January 2020

Metabolomics strategies to discover new biomarkers associated to severe allergic phenotypes.

Asia Pac Allergy 2019 Oct 28;9(4):e37. Epub 2019 Oct 28.

IMMA, Instituto de Medicina Molecular Aplicada, Facultad de Medicina, Universidad San Pablo CEU, Madrid, Spain.

In the last decades have emerged new technological platforms that allow evaluation of genes, transcripts, proteins, or metabolites of a living being, so-called omics sciences. More importantly, new technics for their integration have provided access to a complete set of information of the current conditions and features of a specific biological sample in a precise moment. Thus, omic sciences are now considered an essential tool for patient stratification in base to their severity, to understand disease progression and to identify new biomarkers. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826109PMC
October 2019

New ERS cough guidelines: A clinical framework for refining the patient management strategy.

Asia Pac Allergy 2019 Oct 25;9(4):e36. Epub 2019 Oct 25.

Respiratory Research Group, University of Hull, Hull York Medical School, Castle Hill Hospital, Cottingham, East Yorkshire, United Kingdom.

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http://dx.doi.org/10.5415/apallergy.2019.9.e36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826112PMC
October 2019

Continued loss of asthma control following epidemic thunderstorm asthma.

Asia Pac Allergy 2019 Oct 17;9(4):e35. Epub 2019 Oct 17.

Eastern Health, Melbourne, VIC, Australia.

Background: Epidemic thunderstorm asthma (ETSA) severely affected Melbourne, Australia in November 2016. There is scant literature on the natural history of individuals affected by ETSA.

Objective: A multicentre 12-month prospective observational study was conducted assessing symptomatology and behaviors of ETSA-affected individuals. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826110PMC
October 2019

Goat's milk anaphylaxis in a cow's milk tolerant child.

Asia Pac Allergy 2019 Oct 17;9(4):e34. Epub 2019 Oct 17.

Allergy Service, Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore.

Goat's milk (GM) allergy commonly occurs together with cow's milk (CM) allergy due to cross-reactivity between highly homologous proteins. We present an unusual case of GM anaphylaxis in a CM tolerant child. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826113PMC
October 2019

The risk of preschool asthma at 2-4 years is not associated with leukocyte telomere length at birth or at 1 year of age.

Asia Pac Allergy 2019 Oct 14;9(4):e33. Epub 2019 Oct 14.

Department of Pediatrics, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.

Background: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship.

Objective: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period.

Methods: We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826115PMC
October 2019

Respiratory syncytial virus increases eosinophil extracellular traps in a murine model of asthma.

Asia Pac Allergy 2019 Oct 14;9(4):e32. Epub 2019 Oct 14.

Laboratory of Pediatric Respirology - Infant Center, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.

Background: Respiratory viral infections are the leading cause of asthma exacerbations. Eosinophil activation results in the formation of eosinophil extracellular traps (EETs), which release web-like structures of DNA and proteins that bind, disarm and extracellularly kill pathogens.

Objective: We investigated whether the respiratory syncytial virus (RSV) could induce EETs in bronchoalveolar lavage fluid eosinophils in a murine model of asthma. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826116PMC
October 2019

Cough related to swallowing in asthma patients.

Asia Pac Allergy 2019 Oct 14;9(4):e31. Epub 2019 Oct 14.

Department of Pulmonology, National Hospital Organization Disaster Medical Center, Tokyo, Japan.

Background: Occurrence of cough during swallowing is common among asthma patients, but has not been investigated in detail.

Objective: We conducted an observational study to determine the prevalence of swallowing-related cough (SRC) and its characteristics in asthma patients.

Methods: Asthma patients attending our outpatient department between May 2005 and April 2007 were interviewed to investigate if they had ever experienced SRC, as well as postnasal drip or heartburn and cough related to these conditions. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826117PMC
October 2019

IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset.

Asia Pac Allergy 2019 Oct 14;9(4):e30. Epub 2019 Oct 14.

Centre Hospitalier Universitaire de Montpellier, Hôpital Arnaud-de-Villeneuve, Département de Pneumologie et Addictologie, unité Exploration des Allergies, 34295 Montpellier, France.

Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826111PMC
October 2019

Chlorhexidine: a hidden life-threatening allergen.

Asia Pac Allergy 2019 Oct 1;9(4):e29. Epub 2019 Aug 1.

Serviço de Imunoalergologia, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte EPE, Portugal.

Chlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Anaphylaxis to chlorhexidine is a rare but potentially life-threatening complication. Epidemiologic data suggest that the cases of chlorhexidine allergy appears to be increasing. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826114PMC
October 2019

Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease.

Asia Pac Allergy 2019 Jul 31;9(3):e28. Epub 2019 Jul 31.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.

Eosinophilic esophagitis (EoE) is a recently recognized esophageal inflammatory disease with clinical manifestations arising from esophageal dysfunction. The etiology of EoE is currently being clarified and food allergy is evolving as the central cornerstone of EoE disease pathogenesis. Given the large number of eosinophils in the esophagus of people with EoE verified by data from murine models EoE is widely considered as the hallmark T-helper type 2 (Th2) disease of the esophagus. Read More

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http://mr.crossref.org/iPage?doi=10.5415%2Fapallergy.2019.9.
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http://dx.doi.org/10.5415/apallergy.2019.9.e28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676061PMC
July 2019
6 Reads

Actions needed for "Allergy in Asia-Pacific".

Authors:
Jiu-Yao Wang

Asia Pac Allergy 2019 Jul 29;9(3):e27. Epub 2019 Jul 29.

Allergy and Clinical Immunology Research Center, Division of Allergy and Clinical Immunology, Department of Pediatrics, National Cheng Kung University College of Medicine, Tainan 704, Taiwan.

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http://dx.doi.org/10.5415/apallergy.2019.9.e27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676059PMC
July 2019
5 Reads

Measuring the quality of life of the families of children with eczema in Hong Kong.

Asia Pac Allergy 2019 Jul 17;9(3):e26. Epub 2019 Jul 17.

Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Eczema is the most common skin problem among children in Hong Kong. Previous studies have highlighted that the quality of life of the families of children with eczema influences the effects of eczema interventions. However, the Chinese version of the Family Dermatology Life Quality Index (C-FDLQI), a tool for measuring the quality of life of the families of children with eczema, has not yet been validated. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676062PMC
July 2019
1 Read

Cross-reactivity of pink peppercorn in cashew and pistachio allergic individuals.

Asia Pac Allergy 2019 Jul 12;9(3):e25. Epub 2019 Jul 12.

Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore.

Background: The Pink peppercorn belongs to the same Anacardiaceae family as cashew and pistachio. However, the cross-reactivity of pink peppercorn with cashew and pistachio has yet to be studied. To date, there has been a single case report of anaphylaxis to pink peppercorn in a cashew and pistachio allergic individual. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676063PMC
July 2019
5 Reads

A survey of management practices in coexistent allergic rhinitis and asthma (Asia-pacific Survey of Physicians on Asthma and allergic Rhinitis): results from Thailand.

Asia Pac Allergy 2019 Jul 9;9(3):e24. Epub 2019 Jul 9.

GlaxoSmithKline Limited, Singapore.

Background: Underdiagnosis and undertreatment of allergic rhinitis (AR) in patients with asthma can worsen treatment outcomes. There is limited evidence of clinical practices for management of coexistent AR-asthma in Thailand.

Methods: A multicountry, cross-sectional study (Asia-pacific Survey of Physicians on Asthma and allergic Rhinitis) to evaluate physician perceptions and management practices related to AR-asthma overlap in 6 Asian countries was conducted. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676060PMC
July 2019
1 Read

Concurrent bilateral juvenile temporal arteritis and hypereosinophilic syndrome: a case report and review of the literature.

Asia Pac Allergy 2019 Jul 8;9(3):e23. Epub 2019 Jul 8.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Most of temporal arteritis occurs in the older patient over 50 years old, and the histopathologic finding shows a granulomatous inflammation, so this called giant cell arteritis. However, the young patients also present with a nodular lesion in their temple, and juvenile temporal arteritis (JTA) should be considered as one of the differential diagnosis, although it is very rare. For both diagnosis and treatment of JTA, excisional biopsy is essential. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676065PMC
July 2019
5 Reads

Association of gene polymorphisms with chronic rhinosinusitis with and without nasal polyp.

Asia Pac Allergy 2019 Jul 8;9(3):e22. Epub 2019 Jul 8.

Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Background: Chronic rhinosinusitis (CRS) is one of the most common and complex chronic inflammatory disease of sinonasal mucosa. Even though the pathogenesis of CRS is multifactorial and still unclear, the role of cytokines especially interleukin-1 (IL-1) is being investigated worldwide in different population because of varying results obtained.

Objective: To study the association of ( and ) gene polymorphisms with chronic rhinosinusitis with nasal polyp (CRSwNP) and without nasal polyp (CRSsNP), and other factors related. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676066PMC
July 2019
1 Read

Predictive value of peanut skin prick test, specific IgE in peanut-sensitized children in Singapore.

Asia Pac Allergy 2019 Jul 8;9(3):e21. Epub 2019 Jul 8.

Allergy Service, Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore.

Background: The predictive decision points for both peanut skin prick test (SPT) wheal size and serum IgE concentrations, in peanut-sensitized children, have not been evaluated in Singapore.

Objective: We aim to derive clinically useful predictive decision points to be used for risk stratification of oral food challenge (OFC) in peanut-sensitized patients.

Methods: Patients with a positive SPT to peanut, performed during a 4-year period between 2012 and 2016, were included in a retrospective chart review. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676064PMC

Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond.

Asia Pac Allergy 2019 Jul 31;9(3):e20. Epub 2019 May 31.

Northern Clinical School, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in a very great burden of disease. These reactions not only carry with them a high mortality (10%-50%) and high morbidity (60%) with severe ocular complications, alopecia, oral and dental complications and development of autoimmune diseases, but also create a substantial economic burden for patients' families and society. SCARs are, therefore, an important medical problem needing a solution in many countries, especially in Asia. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676067PMC
July 2019
6 Reads

Importance of comprehensive allergological workup in corticosteroid allergy.

Asia Pac Allergy 2019 Apr 23;9(2):e19. Epub 2019 Apr 23.

Department of Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.5415/apallergy.2019.9.e19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494654PMC
April 2019
1 Read

Additive effect of L-92 on children with atopic dermatitis concomitant with food allergy.

Asia Pac Allergy 2019 Apr 22;9(2):e18. Epub 2019 Apr 22.

Department of Allergy, Aichi Children's Health and Medical Center, Obu 474-8710, Japan.

Background: Atopic dermatitis (AD) in infants is often related to food allergies (FA). The beneficial effects of lactic acid bacteria towards allergic diseases have been reported, but there are few reports on their effect and preferable dosages on AD in young children with concomitant FA.

Objective: To examine additional effects of two different dose of paraprobiotic L-92 (L-92) on the clinical treatment in young children afflicted by AD with diagnosed or suspected FA. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494655PMC
April 2019
5 Reads

The prevalence of allergic diseases in school children of metropolitan city in Indonesia shows a similar pattern to that of developed countries.

Asia Pac Allergy 2019 Apr 20;9(2):e17. Epub 2019 Apr 20.

Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

Background: The prevalence of allergy among Surabaya school children is currently unknown.

Objective: To identify the prevalence of the common allergic sensitization and allergic diseases among school children and undergraduate students in suburban of Surabaya by epidemiologic data collection.

Methods: A multistage simple random sampling was done to select 5 primary schools, 8 secondary schools (4 of junior high schools and senior high schools, respectively), and 1 university from 5 districts in Surabaya city. Read More

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http://mr.crossref.org/iPage?doi=10.5415%2Fapallergy.2019.9.
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http://dx.doi.org/10.5415/apallergy.2019.9.e17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494661PMC
April 2019
18 Reads

Environmental triggers for chronic cough.

Asia Pac Allergy 2019 Apr 20;9(2):e16. Epub 2019 Apr 20.

Airway Sensation and Cough Research Laboratory, Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Cough is a physiological defense reflex for protecting the airways from aspiration and irritation. Thus, roles of environmental triggers are postulated in the pathogenesis of chronic cough. There are several lines of epidemiological evidence demonstrating the relationships between environmental irritant and pollutant exposure and chronic cough. Read More

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http://mr.crossref.org/iPage?doi=10.5415%2Fapallergy.2019.9.
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http://dx.doi.org/10.5415/apallergy.2019.9.e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494656PMC
April 2019
18 Reads

Tick killing before removal to prevent allergic and anaphylactic reactions in humans: a cross-sectional study.

Asia Pac Allergy 2019 Apr 18;9(2):e15. Epub 2019 Apr 18.

Department of Emergency Medicine, Northern Beaches Hospital, Sydney, Australia.

Background: Tick anaphylaxis is a potentially fatal outcome of improper tick removal and management.

Objective: To investigate whether killing ticks in-situ with ether-containing sprays or permethrin cream, before careful removal by the mouthparts could reduce this risk.

Methods: This was a prospective study at Mona Vale Hospital Emergency Department (ED) in Sydney, New South Wales, over a 6-month period during the peak tick season of 2016. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494660PMC
April 2019
11 Reads

Successful cholecalciferol desensitisation in a case of delayed hypersensitivity.

Asia Pac Allergy 2019 Apr 18;9(2):e14. Epub 2019 Apr 18.

HIV, Immunology & Infectious Diseases Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia.

Hypersensitivity to cholecalciferol (vitamin D) or its active metabolite, calcitriol, is an exceedingly rare clinical phenomenon, with only 2 previously reported cases of suspected immediate hypersensitivity. Diagnosis of delayed drug hypersensitivity reactions is inherently difficult due to the lack of any robust diagnostic assay, particularly in those patients for whom provocation testing confers an unacceptable risk. In these situations, diagnosis relies on reproducible clinical manifestations following administration of the culprit agent, resolution upon its withdrawal and exclusion of other potential differential diagnoses. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494657PMC
April 2019
5 Reads

Anaphylaxis affects primarily the heart and coronary arteries: Implications of Kounis syndrome.

Asia Pac Allergy 2019 Apr 18;9(2):e13. Epub 2019 Apr 18.

Department of Electrophysiology, Queen Elizabeth Hospital, Birmingham, United Kingdom.

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http://dx.doi.org/10.5415/apallergy.2019.9.e13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494659PMC
April 2019
3 Reads

Carrying rates of epinephrine devices in children with food-induced anaphylaxis.

Asia Pac Allergy 2019 Apr 17;9(2):e12. Epub 2019 Apr 17.

Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Carrying epinephrine can save lives in patients with anaphylaxis. The feature of epinephrine in prefilled syringe that commonly prescribed in Thailand may influence the willingness to carry. However, the rates of carrying prefilled syringe epinephrine are unknown in children with history of food-induced anaphylaxis. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494658PMC
April 2019
7 Reads

Climate change, air pollution, and biodiversity in Asia Pacific: impact on allergic diseases.

Authors:
Ruby Pawankar

Asia Pac Allergy 2019 Apr 3;9(2):e11. Epub 2019 Apr 3.

Department of Pediatrics, Nippon Medical School, Tokyo, Japan.

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http://dx.doi.org/10.5415/apallergy.2019.9.e11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494653PMC
April 2019
1 Read