883,933 results match your criteria Asia Pacific Journal Of Marketing And Logistics[Journal]


Global declines in human-driven mangrove loss.

Glob Chang Biol 2020 Jul 12. Epub 2020 Jul 12.

Biospheric Sciences Laboratory, NASA Goddard Space Flight Center, 8800 Greenbelt Road, Greenbelt, MD, USA.

Global mangrove loss has been attributed primarily to human activity. Anthropogenic loss hotspots across Southeast Asia and around the world have characterized the ecosystem as highly threatened, though natural processes such as erosion can also play a significant role in forest vulnerability. However, the extent of human and natural threats has not been fully quantified at the global scale. Read More

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http://dx.doi.org/10.1111/gcb.15275DOI Listing

Peste des petits ruminants in Africa: a review of currently available molecular epidemiological data, 2020.

Arch Virol 2020 Jul 11. Epub 2020 Jul 11.

Animal Production and Health Laboratory, Animal Production and Health Section, Joint FAO/IAEA Division, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Friedenstrasse, 1, 2444, Vienna, Seibersdorf, Austria.

Small ruminants (e.g., sheep and goats) contribute considerably to the cash income and nutrition of small farmers in most countries in Africa and Asia. Read More

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http://dx.doi.org/10.1007/s00705-020-04732-1DOI Listing

Investigating the genetic characteristics of the Csangos, a traditionally Hungarian speaking ethnic group residing in Romania.

J Hum Genet 2020 Jul 11. Epub 2020 Jul 11.

Department of Medical Genetics, Clinical Centre, University of Pécs, Pécs, Hungary.

Csango people are an East-Central European ethnographic group living mostly in the historical region of Moldavia, Romania. Their traditional language, the Csango is an old Hungarian dialect, which is a severely endangered language due to language shift. Their origin is still disputed among experts and there are many hypotheses since the 19th century. Read More

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http://dx.doi.org/10.1038/s10038-020-0799-6DOI Listing

Paleolithic genetic link between Southern China and Mainland Southeast Asia revealed by ancient mitochondrial genomes.

J Hum Genet 2020 Jul 11. Epub 2020 Jul 11.

Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, CAS, 100044, Beijing, China.

The genetic history of Southern East Asians is not well-known, especially prior to the Neolithic period. To address this, we successfully sequenced two complete mitochondrial genomes of 11,000-year-old human individuals from Southern China, thus generating the oldest ancient DNA sequences from this area. Integrating published mitochondrial genomes, we characterized M71d, a new subhaplogroup of haplogroup M71. Read More

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http://dx.doi.org/10.1038/s10038-020-0796-9DOI Listing

Mitochondria in acute myocardial infarction and cardioprotection.

EBioMedicine 2020 Jul 9;57:102884. Epub 2020 Jul 9.

National Heart Research Institute Singapore, National Heart Centre, Singapore; Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; Department of Biochemistry, Medical Faculty, Justus Liebig-University, Giessen, Germany; Yong Loo Lin School of Medicine, National University Singapore, Singapore; The Hatter Cardiovascular Institute, University College London, London, UK; Cardiovascular Research Center, College of Medical and Health Sciences, Asia University, Taiwan. Electronic address:

Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the leading causes of death and disability worldwide. As such, new treatments are needed to protect the myocardium against the damaging effects of the acute ischaemia and reperfusion injury (IRI) that occurs in AMI, in order to reduce myocardial infarct (MI) size, preserve cardiac function, and improve patient outcomes. In this regard, cardiac mitochondria play a dual role as arbiters of cell survival and death following AMI. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102884DOI Listing

Management of Idiopathic CNS inflammatory diseases during the COVID-19 pandemic: Perspectives and strategies for continuity of care from a South East Asian Center with limited resources.

Authors:
S Viswanathan

Mult Scler Relat Disord 2020 Jul 3;44:102353. Epub 2020 Jul 3.

Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia. Electronic address:

The Covid-19 pandemic poses a grave health management challenge globally of unprecedented nature. Management of idiopathic Central Nervous system inflammatory disorders (iCNSID) such as Multiple sclerosis, Neuromyelitis optica and its spectrum disorders and related conditions during this pandemic needs to be addressed with affirmative and sustainable strategies in order to prevent disease related risks, medication related complications and possible COVID-19 disease associated effects. Global international iCNSIDs agencies and recent publications are attempting to address this but such guidance is not available in South East Asia. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102353DOI Listing

Full-length transcriptome sequencing and modular organization analysis of oleanolic acid- and dammarane-type saponin related gene expression patterns in Panax japonicus.

Genomics 2020 Jul 9. Epub 2020 Jul 9.

School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China. Electronic address:

The saponins found in Panax japonicus, a traditional medicinal herb in Asia, exhibit high degrees of structural and functional similarity. In this study, metabolite analysis revealed that oleanolic acid-type and dammarane-type saponins were distributed unevenly in three tissues (rhizome_Y, rhizome_O, and secRoot) of P. japonicus. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.06.045DOI Listing

A systematic review of asthma case definitions in 67 birth cohort studies.

Paediatr Respir Rev 2020 Feb 21. Epub 2020 Feb 21.

Centre for Longitudinal Research, University of Auckland, Auckland, New Zealand; Department of Paediatrics: Child & Youth Health, University of Auckland, Auckland, New Zealand; General Paediatrics, Starship Children's Hospital, Auckland, New Zealand. Electronic address:

Background: Birth cohort studies are a valuable source of information about potential risk factors for childhood asthma. To better understand similarities and variations in findings between birth cohort studies, the methodologies used to measure asthma require consideration.

Objective: To review and appraise the definitions of "asthma" used in birth cohort studies. Read More

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http://dx.doi.org/10.1016/j.prrv.2019.12.005DOI Listing
February 2020

Reviews of emission of biogenic volatile organic compounds (BVOCs) in Asia.

J Environ Sci (China) 2020 Sep 13;95:266-277. Epub 2020 Jun 13.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Biogenic volatile organic compounds (BVOCs) in the atmosphere play important roles in the formation of ground-level ozone and secondary organic aerosol (SOA) in global scale and also in regional scale under some condition due to their large amount and relatively higher reactivity. In places with high plant cover in the tropics and in China where air pollution is serious, the effect of BVOCs on ozone and secondary organic aerosols is strong. The present research aims to provide a comprehensive review about the emission rate, emission inventory, research methods, the influencing factors of BVOCs emissions, as well as their impacts on atmospheric environment quality and human health in recent years in Asia based on the summary and analysis of literatures. Read More

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http://dx.doi.org/10.1016/j.jes.2020.04.043DOI Listing
September 2020

Detection of paternal origin of fetal trisomy 21 in a pregnancy with isolated ventriculomegaly but without advanced parental age.

Taiwan J Obstet Gynecol 2020 Jul;59(4):610-612

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Bioengineering, Tatung University, Taipei, Taiwan.

Objective: We present detection of paternal origin of fetal trisomy 21 in a pregnancy with isolated ventriculomegaly but without advanced parental age.

Case Report: A 29-year-old pregnant woman was admitted to the hospital at 18 weeks of gestation for tocolytic treatment because of irregular uterine contractions. Her husband was 30 years old. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.05.025DOI Listing

Detection of paternal origin of fetal trisomy 18 in a pregnancy conceived by assisted reproductive technology and in vitro fertilization.

Taiwan J Obstet Gynecol 2020 Jul;59(4):607-609

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Bioengineering, Tatung University, Taipei, Taiwan.

Objective: We present detection of paternal origin of fetal trisomy 18 in a pregnancy conceived by assisted reproductive technology (ART) and in vitro fertilization (IVF).

Case Report: A 39-year-old woman underwent ART and IVF because of primary infertility. The woman was infertile because of myoma and endometriosis. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.05.024DOI Listing

Prenatal diagnosis of mosaicism for trisomy 12 in a single colony at amniocentesis in a pregnancy with a favorable outcome.

Taiwan J Obstet Gynecol 2020 Jul;59(4):604-606

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Bioengineering, Tatung University, Taipei, Taiwan.

Objective: We present prenatal diagnosis of mosaicism for trisomy 12 in a single colony at amniocentesis with a favorable outcome.

Case Report: A 36-year-old woman underwent amniocentesis at 18 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 47,XY,+12[1]/46,XY[14]. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.05.023DOI Listing

Prenatal diagnosis and molecular cytogenetic characterization of a chromosome 1q42.3-q44 deletion in a fetus associated with ventriculomegaly on prenatal ultrasound.

Taiwan J Obstet Gynecol 2020 Jul;59(4):598-603

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Bioengineering, Tatung University, Taipei, Taiwan.

Objective: We present prenatal diagnosis and molecular cytogenetic characterization of a chromosome 1q42.3-q44 deletion in a fetus associated with ventriculomegaly on prenatal ultrasound, and we discuss the genotype-phenotype correlation.

Case Report: A 36-year-old woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.05.022DOI Listing

Prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome derived from inv dup(15).

Taiwan J Obstet Gynecol 2020 Jul;59(4):580-585

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Bioengineering, Tatung University, Taipei, Taiwan.

Objective: We present prenatal diagnosis and molecular cytogenetic characterization of an inverted duplication of proximal chromosome 15 [inv dup(15)] presenting as a small supernumerary marker chromosome (sSMC) at amniocentesis associated with concomitant microduplication of 8q22.1.

Materials And Methods: A 39-year-old woman underwent amniocentesis at 16 weeks of gestation because of advanced maternal age, and the result was 47, XY, +mar dn. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.05.019DOI Listing

Introduce the outstanding research paper awards of the Taiwan Association of Obstetrics and Gynecology and Hsu Chien-Tien Cancer Foundation in 2020.

Taiwan J Obstet Gynecol 2020 Jul;59(4):477-478

Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Hsinchu Branch, Hsinchu, Taiwan.

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http://dx.doi.org/10.1016/j.tjog.2020.05.001DOI Listing

Margetuximab plus pembrolizumab in patients with previously treated, HER2-positive gastro-oesophageal adenocarcinoma (CP-MGAH22-05): a single-arm, phase 1b-2 trial.

Lancet Oncol 2020 Jul 9. Epub 2020 Jul 9.

Seoul National University College of Medicine, Seoul, South Korea.

Background: Margetuximab, a novel, investigational, Fc-engineered, anti-HER2 monoclonal antibody, is designed to more effectively potentiate innate immunity than trastuzumab. We aimed to evaluate the safety, tolerability, and antitumour activity of margetuximab plus pembrolizumab (an anti-PD-1 monoclonal antibody) in previously treated patients with HER2-positive gastro-oesophageal adenocarcinoma.

Methods: CP-MGAH22-05 was a single-arm, open-label, phase 1b-2 dose-escalation and cohort expansion study done at 11 academic centres in the USA and Canada and 15 centres in southeast Asia (Korea, Taiwan, and Singapore) that enrolled men and women aged 18 years or older with histologically proven, unresectable, locally advanced or metastatic, HER2-positive, PD-L1-unselected gastro-oesophageal adenocarcinoma, with an Eastern Cooperative Oncology Group performance status of 0 or 1, who had progressed after at least one previous line of therapy with trastuzumab plus chemotherapy in the locally advanced unresectable or metastatic setting. Read More

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http://dx.doi.org/10.1016/S1470-2045(20)30326-0DOI Listing

A young male with chronic nonproductive cough diagnosed with blastomycosis in China: a case report.

BMC Pulm Med 2020 Jul 11;20(1):189. Epub 2020 Jul 11.

Department of Respiratory, Shanghai East Hospital, Affiliated to Tongji University, No.150 Jimo Road, Pudong District, Shanghai, 200020, People's Republic of China.

Background: Blastomycosis is a fungal infectious disease prevalent in North America and rarely reported in Asia. Misdiagnosis of malignancy and other infectious diseases were reported.

Case Presentation: A 24-years-old male patient presented with chronic non-productive cough of 4 months duration. Read More

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http://dx.doi.org/10.1186/s12890-020-01225-4DOI Listing

A literature review of the use of environmental sampling in the surveillance of avian influenza viruses.

Transbound Emerg Dis 2020 Jul 11. Epub 2020 Jul 11.

Asia Pacific Veterinary Information Services, Melbourne, Australia.

This literature review provides an overview of use of environmental samples (ES) such as faeces, water, air, mud and swabs of surfaces in avian influenza (AI) surveillance programs, focussing on effectiveness, advantages and gaps in knowledge. ES have been used effectively for AI surveillance since the 1970s. Results from ES have enhanced understanding of the biology of AI viruses in wild birds and in markets, of links between human and avian influenza, provided early warning of viral incursions, allowed assessment of effectiveness of control and preventive measures, and assisted epidemiological studies in outbreaks, both avian and human. Read More

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http://dx.doi.org/10.1111/tbed.13633DOI Listing

Managing acute type A aortic dissections: Is a universal approach feasible?

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Division of Cardiac Surgery, Department of Cardiothoracic Surgery, Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.

The goal in the treatment of acute type A aortic dissection (ATAAD) is to resect the primary intimal tear while minimizing associated complications of the disease. This goal can be accomplished by different surgical techniques and operative strategies. The extent of proximal and distal aortic reconstruction and the use of cerebral perfusion adjuncts are highly variable between institutions and within institutions themselves. Read More

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http://dx.doi.org/10.1111/jocs.14767DOI Listing

Effect of multidisciplinary team care on the risk of recurrence in breast cancer patients: A national matched cohort study.

Breast 2020 Jul 3;53:68-76. Epub 2020 Jul 3.

Department of Health Services Administration, China Medical University, Taichung, Taiwan, ROC. Electronic address:

Background: Cancer has been the leading cause of death in the past decade in Taiwan, with breast cancer being the most common type of cancer in females. Very few studies looked at the risk of recurrence in patients who received multidisciplinary team (MDT) care. We analyzed the influence of MDT on the risk of recurrence and death in breast cancer patients. Read More

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http://dx.doi.org/10.1016/j.breast.2020.07.001DOI Listing

Evolutionary and phylogenetic aspects of the chloroplast genome of Chaenomeles species.

Sci Rep 2020 Jul 10;10(1):11466. Epub 2020 Jul 10.

National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Chaenomeles (family Rosaceae) is a genus of five diploid species of deciduous spiny shrubs that are native to Central Asia and Japan. It is an important horticultural crop (commonly known as flowering quinces) in Europe and Asia for its high yield in fruits that are rich in juice, aroma, and dietary fiber. Therefore, the development of effective genetic markers of Chaenomeles species is advantageous for crop improvement through breeding and selection. Read More

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http://dx.doi.org/10.1038/s41598-020-67943-1DOI Listing

Findings from a context specific accreditation assessment at 38 public midwifery education institutions in Bangladesh.

Women Birth 2020 Jul 7. Epub 2020 Jul 7.

School of Education, Health and Social Studies, Dalarna University, Falun, Sweden; Department of Women's and Children's Health, Karolinska Institute, Solna, Sweden.

Background: In order to promote sustainable midwifery education, it is important to understand what the structural shortcomings are. In this study of 38 public nursing institutions in Bangladesh, we aim to identify a number of structural shortcomings and to discuss strategies for limiting them.

Methods: An evaluated context-specific accreditation assessment tool consisting of 37 multi-choice closed-response questions encompassing 14 educational standards aligned with international standards for midwifery education programs and competences for midwifery educators was used to assess all public nursing institutions in Bangladesh (n=38), the results of which are presented in simple descriptive statistics; number (n), percentage (%), mean, SD and minimum-maximum value. Read More

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http://dx.doi.org/10.1016/j.wombi.2020.06.009DOI Listing

How Shenzhen, China avoided widespread community transmission: a potential model for successful prevention and control of COVID-19.

Infect Dis Poverty 2020 Jul 10;9(1):89. Epub 2020 Jul 10.

Shenzhen Center for Disease Control and Prevention, Shenzhen, China.

Shenzhen is a city of 22 million people in south China that serves as a financial and trade center for East Asia. The city has extensive ties to Hubei Province, the first reported epicenter of the coronavirus disease 2019 (COVID-19) outbreak in the world. Initial predictions suggested Shenzhen would experience a high number of COVID-19 cases. Read More

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http://dx.doi.org/10.1186/s40249-020-00714-2DOI Listing

Universities as catalysts of social innovation in health systems in low-and middle-income countries: a multi-country case study.

Infect Dis Poverty 2020 Jul 11;9(1):90. Epub 2020 Jul 11.

London School of Hygiene and Tropical Medicine, London, UK.

Background: Social innovation (SI) in health holds potential to contribute to health systems strengthening and universal health coverage (UHC). The role of universities in SI has been well described in the context of high-income countries. An evidence gap exits on SI in healthcare delivery in the context of low- and middle-income countries (LMICs) as well as on the engagement of universities from these contexts. Read More

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http://dx.doi.org/10.1186/s40249-020-00684-5DOI Listing

Phylogenetic and spatial distribution of evolutionary diversification, isolation, and threat in turtles and crocodilians (non-avian archosauromorphs).

BMC Evol Biol 2020 Jul 10;20(1):81. Epub 2020 Jul 10.

Department of Biological Sciences, The George Washington University, Washington, DC, 20052, USA.

Background: The origin of turtles and crocodiles and their easily recognized body forms dates to the Triassic and Jurassic. Despite their long-term success, extant species diversity is low, and endangerment is extremely high compared to other terrestrial vertebrate groups, with ~ 65% of ~ 25 crocodilian and ~ 360 turtle species now threatened by exploitation and habitat loss. Here, we combine available molecular and morphological evidence with statistical and machine learning algorithms to present a phylogenetically informed, comprehensive assessment of diversification, threat status, and evolutionary distinctiveness of all extant species. Read More

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http://dx.doi.org/10.1186/s12862-020-01642-3DOI Listing

Neuroprotective and Anti-Inflammatory Effects of Kuwanon C from Are Mediated by Heme Oxygenase-1 in HT22 Hippocampal Cells, RAW264.7 Macrophage, and BV2 Microglia.

Int J Mol Sci 2020 Jul 8;21(14). Epub 2020 Jul 8.

College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea.

Heme oxygenase (HO)-1 is a detoxifying phase II enzyme that plays a role in both inflammatory and oxidative stress responses. is widespread throughout East Asia and is used as a therapeutic agent in traditional medicine. We investigated whether treatment with sixteen flavonoid or xanthone compounds from could induce HO-1 expression in HT22 hippocampal cells, RAW264. Read More

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http://dx.doi.org/10.3390/ijms21144839DOI Listing

"A Woman Is a Puppet." Women's Disempowerment and Prenatal Anxiety in Pakistan: A Qualitative Study of Sources, Mitigators, and Coping Strategies for Anxiety in Pregnancy.

Int J Environ Res Public Health 2020 Jul 8;17(14). Epub 2020 Jul 8.

Department of International Health, Johns Hopkins Bloomberg School of Public Health 615 N. Wolfe St., Baltimore, MD 21205, USA.

Common mental disorders are highly prevalent among pregnant women in low- and middle-income countries, yet prenatal anxiety remains poorly understood, particularly in the sociocultural context of South Asia. Our study explored sources, mitigators, and coping strategies for anxiety among symptomatic pregnant women in Pakistan, particularly in relation to autonomy in decision-making and social support. We interviewed 19 pregnant married women aged 18-37 years recruited from 2017-2018 at a public hospital in Rawalpindi who screened positive for anxiety. Read More

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http://dx.doi.org/10.3390/ijerph17144926DOI Listing

Impact of the Mid-Pleistocene Revolution and Anthropogenic Factors on the Dispersion of Asian Black-Spined Toads ().

Animals (Basel) 2020 Jul 8;10(7). Epub 2020 Jul 8.

Laboratory of Animal Behaviour and Conservation, College of Biology and the Environment, Nanjing Forestry University, Nanjing 210037, China.

Divergence-time estimation critically improves the understanding of biogeography processes underlying the distribution of species, especially when fossil data is not available. We hypothesise that the Asian black-spined toad, , expanded into the Eastern Indomalaya following the Quaternary glaciations with the subsequent colonisation of new landscapes during the Last Glacial Maximum. Divergence dating inferred from 364 sequences of mitochondrial supported the emergence of a common ancestor to the three clades around 1. Read More

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http://dx.doi.org/10.3390/ani10071157DOI Listing

In Vitro Mechanical and Biological Properties of 3D Printed Polymer Composite and β-Tricalcium Phosphate Scaffold on Human Dental Pulp Stem Cells.

Materials (Basel) 2020 Jul 8;13(14). Epub 2020 Jul 8.

Department of Oral and Cranio-Maxillofacial Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.

3D printed biomaterials have been extensively investigated and developed in the field of bone regeneration related to clinical issues. However, specific applications of 3D printed biomaterials in different dental areas have seldom been reported. In this study, we aimed to and successfully fabricated 3D poly (lactic-co-glycolic acid)/β-tricalcium phosphate (3D-PLGA/TCP) and 3D β-tricalcium phosphate (3D-TCP) scaffolds using two relatively distinct 3D printing (3DP) technologies. Read More

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http://dx.doi.org/10.3390/ma13143057DOI Listing

Anti-Metastatic Effects of Plant Sap-Derived Extracellular Vesicles in a 3D Microfluidic Cancer Metastasis Model.

J Funct Biomater 2020 Jul 8;11(3). Epub 2020 Jul 8.

Department of Integrative Biosciences, University of Brain Education, Cheonan 31228, Korea.

Natural medicinal plants have attracted considerable research attention for their potential as effective drugs. The roots, leaves and stems of the plant, , which is endemic to southern regions of Asia, have long been used as a folk medicine to treat variety of diseases. However, the sap of this plant has not been widely studied and its bioactive properties have yet to be clearly elucidated. Read More

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http://dx.doi.org/10.3390/jfb11030049DOI Listing

Defining EUS Features of Chronic Pancreatitis in Asians - A Multicentre Validation Study.

Endoscopy 2020 Jul 10. Epub 2020 Jul 10.

National University Hospital, Division of Gastroenterology and Hepatology, Singapore, Singapore.

INTRODUCTION Although EUS features and criteria have been described in chronic pancreatitis, challenges remain with inter-operator variability and ease of adoption. AIMS The aim of the study was to define and validate EUS features of chronic pancreatitis in a multi-center prospective study in Asia. METHOD The study was conducted in 2 phases. Read More

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http://dx.doi.org/10.1055/a-1217-3112DOI Listing

Air quality during the COVID-19: PM analysis in the 50 most polluted capital cities in the world.

Environ Pollut 2020 Jul 3;266(Pt 1):115042. Epub 2020 Jul 3.

Universidad EAN, Bogotá, Colombia. Electronic address:

On December 31, 2019, the Chinese authorities reported to the World Health Organization (WHO) the outbreak of a new strain of coronavirus that causes a serious disease in the city of Wuhan, China. This outbreak was classified as SARS-CoV2 and is the cause of the COVID-19 disease. On March 11, 2020, the WHO declares it a Pandemic and today it is considered the greatest challenge in global health that humanity has faced since World War II and it is estimated that between 40 and 60% of the population worldwide will catch the virus. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.115042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333997PMC

Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression.

Cell 2020 Jul;182(1):226-244.e17

Institute of Chemistry, Academia Sinica, Taipei, Taiwan; Department of Chemistry, National Taiwan University, Taipei, Taiwan. Electronic address:

Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To illuminate the molecular phenotype of this demographically distinct disease, we performed a deep comprehensive proteogenomic study on a prospectively collected cohort in Taiwan, representing early stage, predominantly female, non-smoking lung adenocarcinoma. Integrated genomic, proteomic, and phosphoproteomic analysis delineated the demographically distinct molecular attributes and hallmarks of tumor progression. Read More

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http://dx.doi.org/10.1016/j.cell.2020.06.012DOI Listing

Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway.

Pharm Biol 2020 Dec;58(1):655-663

Department of Cardiac Surgery, Wuhan Asia Heart Hospital, Wuhan, P.R. China.

Context: Baicalin is an active compound which demonstrates cardioprotection effects against myocardial ischaemia/reperfusion injury (MI/RI).

Objective: To investigate how baicalin protects against myocardial injury and to explore its potential mechanism. We hypothesized that baicalin-modulated macrophages change from M1 (pro-inflammatory subset) to M2 (anti-inflammatory subset) under I/R stress. Read More

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http://dx.doi.org/10.1080/13880209.2020.1779318DOI Listing
December 2020

The Asian Association for the Study of Diabetes (AASD): The first ten years and the next ten years.

J Diabetes Investig 2020 Jul 10. Epub 2020 Jul 10.

The Office of the Asian Association for the Study of Diabetes, Tokyo, Japan.

The global diabetes population today is 433 million (9.3% of the population aged 20-79 years), and is expected to grow to 700 million (10.9% of the population aged 20-79) by 2045 without effective countermeasures . Read More

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http://dx.doi.org/10.1111/jdi.13353DOI Listing

Dispersal patterns of an introduced wild bee, Megachile sculpturalis Smith, 1853 (Hymenoptera: Megachilidae) in European alpine countries.

PLoS One 2020 10;15(7):e0236042. Epub 2020 Jul 10.

Institute for Integrative Nature Conservation Research, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria.

Biodiversity monitoring programs are the baseline of species abundancy studies, which in case of introduced species are especially critical. Megachile sculpturalis Smith, 1853 native to Eastern-Asia, constitutes the first ever recorded wild bee species accidently introduced in Europe. Since its first discovery in 2008, M. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236042PLOS

Isolated systolic hypertension and 29-year cardiovascular mortality risk in Japanese adults aged 30--49 years.

J Hypertens 2020 Jul 6. Epub 2020 Jul 6.

Department of Public Health.

Objective: The prognostic implication of isolated systolic hypertension (ISH), defined as SBP at least 140 mmHg and DBP less than 90 mmHg, among young-to-middle-aged adults remains controversial. We examined the association of ISH with cardiovascular disease (CVD) risk in adults aged 30-49 years.

Methods: In a prospective cohort of representative Japanese general populations from the NIPPON DATA80 (1980-2009), we studied 4776 participants (mean age, 39. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002533DOI Listing

Modified V-Y Myocutaneous Flap With Vascular Pedicle for the Repair of Maxillofacial Skin Defects.

J Craniofac Surg 2020 Jul 1. Epub 2020 Jul 1.

Department of Stomatology, the Third Xiangya Hospital, Central South University.

Objective: It is challenging to repair postoperative defect caused by skin tumor resection on the maxillofacial, which not only affects appearance but also impairs functions. To better repair skin defect on the maxillofacial, the application value of V-Y vascular myocutaneous flap was introduced in our study.

Methods: Between June 2011 and December 2018, 16 patients with maxillofacial skin tumors who received extensive resection were enrolled in our study. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006745DOI Listing

Gender Differences in Cancer Patients' Preferences for Truth-Telling in Taiwan.

Cancer Nurs 2020 Jul 8. Epub 2020 Jul 8.

Author Affiliations: School of Nursing, Chang Gung University, Taoyuan, Taiwan (Ms. Chen and Dr Tang); Psycho-Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan (Dr Fujimori); and Department of Hematology-Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan (Drs Wang and Tang).

Background: There is a lack of studies investigating gender differences in cancer truth-telling, especially from the Asia Pacific countries.

Objective: The aim of this study was to compare preferences for cancer truth-telling between male and female cancer patients in Taiwan.

Methods: We used a quantitative cross-sectional design. Read More

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http://dx.doi.org/10.1097/NCC.0000000000000856DOI Listing

Tobacco Industry Fingerprints on Delaying Implementation of Pictorial Health Warnings in the Western Pacific.

Asian Pac J Cancer Prev 2020 Jul 1;21(S1):23-25. Epub 2020 Jul 1.

Southeast Asia Tobacco Control Alliance, Bangkok, Thailand.

Objective: This case series describes tobacco industry tactics and strategies used to interfere, derail, delay, and weaken the development of effective health warning regulations in Malaysia, Cambodia, the Philippines, and Hong Kong.

Methods: A historical review of official reports, news articles, and gray literature was undertaken to identify tobacco industry tactics and strategies to hamper government efforts in implementing stronger pictorial health warning regulations in four Asian jurisdictions (Cambodia, Hong Kong, Malaysia, and the Philippines).

Results: Nineteen countries/jurisdictions in the WHO Western Pacific region currently require pictorial health warnings on cigarette packs, including some of the world's largest, in line with the WHO Framework Convention on Tobacco Control Article 11 Guidelines. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.23DOI Listing

Improving Information to Enable Effective Tobacco Control Intervention and Measure Progress Over Time: The Cambodia Country Experience.

Asian Pac J Cancer Prev 2020 Jul 1;21(S1):5-8. Epub 2020 Jul 1.

(Former) South East Asia Tobacco Control Alliance (SEATCA), Bangkok, Thailand.

Tobacco is a leading cause of noncommunicable diseases (NCDs) which kill about 41 million people each year. Of these, 15 million die prematurely between the ages of 30 and 69 years, most of which occur in low- and middle-income countries (LMICs). The adoption of the Sustainable Development Goals and their targets under the 2030 Agenda for Sustainable Development provides a new impetus for countries to accelerate tobacco control efforts as they specifically call for strengthening implementation of the World Health Organization (WHO) Framework Convention on Tobacco Control and striving to achieve a one-third reduction in premature deaths from NCDs. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.5DOI Listing

Sacrocolpopexy tends to be superior to transvaginal mesh surgery.

BJOG 2020 Jul 10. Epub 2020 Jul 10.

Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

The use of synthetic mesh prostheses to treat pelvic organ prolapse (POP) remains highly controversial. Despite complete restriction on vaginally placed mesh in Australia and New Zealand (2017), the UK (2018), and the USA (2019), transvaginal mesh (TVM) prolapse repair remain widely in many countries, including China and most of East Asia. Sacrocolpopexy (SC) is widely considered as the gold-standard for surgical correction of vaginal vault prolapse. Read More

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http://dx.doi.org/10.1111/1471-0528.16407DOI Listing

Impact of the coronavirus disease 2019 (COVID-19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia Region: A report from the Pediatric Oncology East and Mediterranean (POEM) Group.

Cancer 2020 Jul 10. Epub 2020 Jul 10.

Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, Tennessee.

Background: Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated.

Methods: A 34-item survey focusing on barriers to pediatric oncology management during the COVID-19 pandemic was distributed to heads of pediatric oncology units within the Pediatric Oncology East and Mediterranean (POEM) collaborative group, from the Middle East, North Africa, and West Asia. Read More

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http://dx.doi.org/10.1002/cncr.33075DOI Listing

Enhanced Bone Formation in Osteoporotic Mice by a Novel Transplant Combined with Adipose-derived Stem Cells and Platelet-rich Fibrin Releasates.

Cell Transplant 2020 Jan-Dec;29:963689720927398

School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.

Osteoporotic fracture is the main complication of osteoporosis (OP) and accounts for millions of injuries annually. Local intervention by intra-marrow injection has been a good option for preventing osteoporotic bone loss when the osteoporotic femoral fracture has been treated. In this study, tail vein transplantations were examined to evaluate the cell-based therapeutic approach for treating OP with adipose-derived stem cells (ADSCs) and platelet-rich fibrin releasates (PRFr) in an ovariectomized (OVX) mice model. Read More

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http://dx.doi.org/10.1177/0963689720927398DOI Listing

International traditional Chinese medicine guideline for diagnostic and treatment principles of diabetes.

Ann Palliat Med 2020 Jul 10. Epub 2020 Jul 10.

Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Diabetes mellitus (DM) was one of the most severe public health problems that affected nearly 463 million adults around the world. In addition to insulin and oral hypoglycemic agents, traditional Chinese medicine (TCM) was an effective alternative therapy for diabetes and its complications, and it had been widely used in the Pan-Pacific region, especially in Southeast Asia, however, TCM lacked specialized standards of care for DM in the past, which limited the TCM clinical efficacy of diabetes. Since March 2017, the Endocrinology Committee of World Federation of Chinese Medicine Societies (WFCMS) had invited experts in diabetes, TCM, and international standard setting to work with TCM endocrinologists from the Guideline Development Committee to review the TCM clinical research evidence related to the prevention and treatment of diabetes over the previous 14 years. Read More

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http://dx.doi.org/10.21037/apm-19-271DOI Listing

Clinical Practice Guideline Recommendation on the Use of Low Intensity Extracorporeal Shock Wave Therapy and Low Intensity Pulsed Ultrasound Shock Wave Therapy to Treat Erectile Dysfunction: The Asia-Pacific Society for Sexual Medicine Position Statement.

World J Mens Health 2020 Jun 2. Epub 2020 Jun 2.

Department of Urology and Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

Published literature shows low intensity extracorporeal shock wave therapy (LIESWT) and low intensity pulsed ultrasound (LIPUS) therapy to improve erectile function and penile hemodynamic by inducing neovascularisation and promoting tissue regeneration. Key opinion leaders across the Asia Pacific region attended the recent biennial meeting of the Asia Pacific Society for Sexual Medicine in Australia, and presented the current evidence on LIESWT and LIPUS for erectile dysfunction (ED). The clinical findings were internally discussed, and the quality of evidence was graded based on the Oxford Centre for Evidence-Based Medicine recommendations. Read More

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http://dx.doi.org/10.5534/wjmh.200077DOI Listing

Molecular detection of Rickettsia species and host associations of Laelaps mites (Acari: Laelapidae) in Taiwan.

Exp Appl Acarol 2020 Jul 9. Epub 2020 Jul 9.

Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan.

Various rickettsiae have recently been detected in Laelaps mites (Acari: Laelapidae), which are common ectoparasites of rodents; however, investigations on this topic remain very scarce, particularly in Asia. In the present study, shrews and rodents were trapped from 2006 to 2010 in eight lowland regions of Taiwan (< 500 m in elevation) to collect associated Laelaps mites, from which Rickettsia-a group of emerging pathogens-were detected and identified by assaying the gltA and ompB genes. A total of 853 Laelaps mites of at least four species were collected from a sample of 1004 small mammals that included one shrew and 10 rodent species. Read More

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http://dx.doi.org/10.1007/s10493-020-00522-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346847PMC

Erratum to rapid advice guidelines for management of children with COVID-19.

Ann Transl Med 2020 Jun;8(12):807

National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

[This corrects the article DOI: 10.21037/atm-20-3754.]. Read More

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http://dx.doi.org/10.21037/atm-2020-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333161PMC

A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements.

Liver Cancer 2020 Jun 13;9(3):245-260. Epub 2020 May 13.

Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan.

The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. Read More

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http://dx.doi.org/10.1159/000507370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325125PMC

Looks can be deceiving: the deceptive milkcaps (, Russulaceae) exhibit low morphological variance but harbour high genetic diversity.

IMA Fungus 2019 18;10:14. Epub 2019 Sep 18.

Department of Biology, Research group Mycology, Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium.

The ectomycorrhizal genus is known to contain many species complexes, consisting of morphologically very similar species, which can be considered cryptic or pseudocryptic. In this paper, a thorough molecular study is performed of the clade around (originally described by Peck from North America) or the deceptive milkcaps. Even though most collections were identified as , the clade is shown to contain at least 15 species, distributed across Asia and America, indicating that the clade represents a species complex. Read More

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http://dx.doi.org/10.1186/s43008-019-0017-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325672PMC
September 2019
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