876,613 results match your criteria Asia Pacific Journal Of Education[Journal]


Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

Eur Heart J 2020 Jun 4. Epub 2020 Jun 4.

San Raffaele Pisana Scientific Institute, Rome, Italy.

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has important implications for the safety of participants in clinical trials and the research staff caring for them and, consequently, for the trials themselves. Patients with heart failure may be at greater risk of infection with COVID-19 and the consequences might also be more serious, but they are also at risk of adverse outcomes if their clinical care is compromised. As physicians and clinical trialists, it is our responsibility to ensure safe and effective care is delivered to trial participants without affecting the integrity of the trial. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa461DOI Listing

Columnar aerosol properties and radiative effects over Dushanbe, Tajikistan in Central Asia.

Environ Pollut 2020 May 25;265(Pt B):114872. Epub 2020 May 25.

State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China; Center for Excellence in Tibetan Plateau Earth Sciences, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address:

This paper presents the results of the study on columnar aerosol optical and physical properties and radiative effects directly observed over Dushanbe, the capital city of Tajikistan, a NASA AERONET site (equipped with a CIMEL sunphotometer) in Central Asia. The average aerosol optical depth (AOD) and Ångström exponent (AE) during the observation period from July 2010 to April 2018 were found to be 0.28 ± 0. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114872DOI Listing

Rivers of Indochina as potential drivers of lineage diversification in the spotted flying lizard (Draco maculatus) species complex.

Mol Phylogenet Evol 2020 Jun 1:106861. Epub 2020 Jun 1.

Department of Biology and M.I. Bean Life Science Museum, Brigham Young University, 150 East Bulldog Boulevard, Provo, UT, 84602; Department of Biology, Austin Peay State University, Clarksville, TN, 37044. Electronic address:

Southeast Asia hosts a rich concentration of biodiversity within multiple biodiversity hotspots. Indochina, a region with remarkably high levels of in situ diversification, possesses five major rivers (Chiang Mai, Ayeyarwady, Mekong, Salween, and Red), several of which coincide with phylogenetic breaks of terrestrial taxa. Draco maculatus possesses a range that stretches across Indochina, which widespread geographic distribution along with potential discrete variation within subspecies alludes to the possibility of this taxon constituting multiple divergent lineages. Read More

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http://dx.doi.org/10.1016/j.ympev.2020.106861DOI Listing

Phylogenetic and recombinant analyses of complete coding sequences of DENV-1 from field-caught mosquitoes in Thailand.

Virus Res 2020 Jun 1:198041. Epub 2020 Jun 1.

Evolutionary Genetics and Computer Biology Research Unit, Department of Genetics, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Lat Yao District, Chatuchak, Bangkok 10900, Thailand; Centre for Advanced Studies in Tropical Natural Resources, National Research University-Kasetsart University (CASTNAR, NRU-KU, Thailand), 50 Ngam Wong Wan Road, Lat Yao District, Chatuchak, Bangkok 10900, Thailand. Electronic address:

Dengue diseases are a group of infectious diseases that have been widespread throughout the world for several decades. Dengue outbreaks have occurred in many parts of the world, including Southeast Asia. The outbreak and the severity of the diseases depend on many factors including dengue genotype. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198041DOI Listing

Householders' perception about sustaining the useful life of long-lasting insecticide-treated nets in Ghana.

Int Health 2020 Jun 4. Epub 2020 Jun 4.

Department of Planning and Sustainability, School of Geo-Sciences, University of Energy and Natural Resources. P.O.Box 214, Sunyani, Ghana.

Background: This article explores the multifaceted perceptions among householders about the care, efficacy and disposal of long-lasting insecticide-treated nets (LLINs), especially those regarding the end of the useful life of LLINs, and their implications for malaria control.

Methods: We used a cross-sectional qualitative design. Data were gathered in the Shai-Osudoku District in the Greater Accra Region of Ghana using focus group discussions and in-depth interviews. Read More

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http://dx.doi.org/10.1093/inthealth/ihaa019DOI Listing

S100A1 blocks the interaction between p53 and mdm2 and decreases cell proliferation activity.

PLoS One 2020 4;15(6):e0234152. Epub 2020 Jun 4.

Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan.

About 50% of human cancers across the globe arise due to a mutation in the p53 gene which gives rise to its functional inactive form, and in the rest of the cancer the efficacy of active p53 (wild-type) is hindered by MDM2-mediated degradation. Breakdown of the p53-MDM2 association may constitute an effective strategy to stimulate or reinstate the activity of wild type p53, thereby reviving the p53 tumor suppressor capability. S100A1 has been revealed to associate with the N-terminal domain of MDM2 and p53 protein. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234152PLOS

Seatbelt and child restraint use among vehicle occupants in Ho Chi Minh City: an observational study in Vietnam.

Int J Inj Contr Saf Promot 2020 Jun 4:1-8. Epub 2020 Jun 4.

Johns Hopkins International Injury Research Unit, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

This paper presents the trend of seatbelt use, disaggregated by vehicle occupants, in Ho Chi Minh City between 2016 and 2018. We conducted statistical analyses to identify the determinants of seatbelt use, including the effect of a new fine imposed against seatbelt law violation in the rear seats that became effective in January 2018. Seatbelt use was observed in at least half of all vehicle occupants, and drivers were more likely to use seatbelts than passengers. Read More

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http://dx.doi.org/10.1080/17457300.2020.1774620DOI Listing

[Therapeutic progress in the control of uncomplicated Plasmodium falciparum malaria].

Rev Med Liege 2020 May;75(5-6):362-365

Service d'Infectiologie, CHU Liège, Belgique.

Malaria is a worldwide public health problem. In Europe, data show an increasing trend of imported cases in the last ten years. Following an alarming observation reporting resistance to anti-malarial drugs, new effective treatments have been developed in early 21st century. Read More

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Carboxylesterase genes in nitenpyram-resistant brown planthoppers, Nilaparvata lugens.

Insect Sci 2020 Jun 3. Epub 2020 Jun 3.

Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.

Carboxylesterases (CarEs) represent one of the major detoxification enzyme families involved in insecticide resistance. However, the function of specific CarE genes in insecticide resistance is still unclear in the insect Nilaparvata lugens (Stål), a notorious rice crop pest in Asia. In this study, a total of 29 putative CarE genes in N. Read More

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http://dx.doi.org/10.1111/1744-7917.12829DOI Listing

Changing epidemiology and outcomes of acute kidney injury in Brazilian patients: a retrospective study from a teaching hospital.

Int Urol Nephrol 2020 Jun 3. Epub 2020 Jun 3.

Botucatu School of Medicine, UNESP, Botucatu, Brazil.

Purpose: While considerable information is available on acute kidney injury (AKI) in North America and Europe, large comprehensive epidemiologic studies on AKI from Latin America and Asia are still lacking. The present study aimed to evaluate the epidemiology and outcomes of AKI in patients evaluated by nephrologists in a Brazilian teaching hospital.

Methods: We performed a large retrospective observational study that looked into the epidemiology of AKI and its effect on patient outcomes across time periods. Read More

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http://dx.doi.org/10.1007/s11255-020-02512-zDOI Listing

Road development in Asia: Assessing the range-wide risks to tigers.

Sci Adv 2020 May 29;6(18):eaaz9619. Epub 2020 Apr 29.

Department of Biology, University of British Columbia, Kelowna, BC, Canada.

Roads are proliferating worldwide at an unprecedented rate, with potentially severe impacts on wildlife. We calculated the extent and potential impacts of road networks across the 1,160,000-km, 13-country range of the globally endangered tiger ()-a conservation umbrella species. We found that roads were pervasive, totaling 134,000 km across tiger conservation landscapes (TCLs), even in tiger priority sites and protected areas. Read More

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http://dx.doi.org/10.1126/sciadv.aaz9619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190336PMC

Global agricultural economic water scarcity.

Sci Adv 2020 May 29;6(18):eaaz6031. Epub 2020 Apr 29.

Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA, USA.

Water scarcity raises major concerns on the sustainable future of humanity and the conservation of important ecosystem functions. To meet the increasing food demand without expanding cultivated areas, agriculture will likely need to introduce irrigation in croplands that are currently rain-fed but where enough water would be available for irrigation. "Agricultural economic water scarcity" is, here, defined as lack of irrigation due to limited institutional and economic capacity instead of hydrologic constraints. Read More

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http://dx.doi.org/10.1126/sciadv.aaz6031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190309PMC

Tropical cyclone motion in a changing climate.

Sci Adv 2020 Apr 22;6(17):eaaz7610. Epub 2020 Apr 22.

Meteorological Research Institute, Tsukuba, Japan.

The locally accumulated damage by tropical cyclones (TCs) can intensify substantially when these cyclones move more slowly. While some observational evidence suggests that TC motion might have slowed significantly since the mid-20th century (), the robustness of the observed trend and its relation to anthropogenic warming have not been firmly established (-). Using large-ensemble simulations that directly simulate TC activity, we show that future anthropogenic warming can lead to a robust slowing of TC motion, particularly in the midlatitudes. Read More

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http://dx.doi.org/10.1126/sciadv.aaz7610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176414PMC

An integrated research framework combining genomics, systems biology, physiology, modelling and breeding for legume improvement in response to elevated CO under climate change scenario.

Curr Plant Biol 2020 Jun;22:100149

Research Program- Genetic Gains, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, India.

How unprecedented changes in climatic conditions will impact yield and productivity of some crops and their response to existing stresses, abiotic and biotic interactions is a key global concern. Climate change can also alter natural species' abundance and distribution or favor invasive species, which in turn can modify ecosystem dynamics and the provisioning of ecosystem services. Basic anatomical differences in C and C plants lead to their varied responses to climate variations. Read More

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http://dx.doi.org/10.1016/j.cpb.2020.100149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233140PMC

Hepatic and Renal Profile of Scrub Typhus Patients at a Tertiary Care Center in India.

Cureus 2020 May 2;12(5):e7925. Epub 2020 May 2.

Internal Medicine, Government Medical College and Hospital, Chandigarh, IND.

Introduction Scrub typhus is a resurging zoonotic infection prevalent in South Asia with many recent outbreaks in India. It can mimic other tropical infections and the disease spectrum ranges from subclinical illness to life-threatening disease with multiorgan dysfunction. This study was conducted to study the pattern of hepatic and renal injury. Read More

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http://dx.doi.org/10.7759/cureus.7925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265748PMC

Epidemiology of Renal Cell Carcinoma.

World J Oncol 2020 Jun 14;11(3):79-87. Epub 2020 May 14.

Allegheny Health Network, Pittsburgh, PA, USA.

Though renal cell carcinoma (RCC) accounts for 2% of global cancer diagnoses and deaths, it has more than doubled in incidence in the developed world over the past half-century, and today is the ninth most common neoplasm in the United States (US). While North America and Western Europe have the highest disease burden (with the Belarus highest in incidence), Latin America, Asia and Africa are projected to see an increase in incidence as nation's transition to a Western lifestyle. Most cases of RCC are discovered incidentally on imaging, and survival is highly dependent on the stage at diagnosis, with the metastatic disease having only a 12% 5-year survival rate. Read More

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http://dx.doi.org/10.14740/wjon1279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239575PMC

Association Between Attention Deficit Hyperactivity Disorder and Risk of Burn Injury: A Propensity-Matched Cohort Study.

Neuropsychiatr Dis Treat 2020 13;16:1249-1255. Epub 2020 May 13.

Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan.

Purpose: Literature suggests that attention deficit hyperactivity disorder (ADHD) is associated with a high risk of unintentional injury. However, few studies have focused on whether risk of burn injury is relatively high among patients with ADHD. The aim of this study was to investigate whether ADHD affects the risk of burn injury. Read More

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http://dx.doi.org/10.2147/NDT.S242153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231781PMC

Repositioning of the global epicentre of non-optimal cholesterol.

Authors:

Nature 2020 Jun 3;582(7810):73-77. Epub 2020 Jun 3.

High blood cholesterol is typically considered a feature of wealthy western countries. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health. Read More

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http://dx.doi.org/10.1038/s41586-020-2338-1DOI Listing

Phase 3, Randomized, Double-Blind, Active-Comparator (Darbepoetin Alfa) Study of Oral Roxadustat in CKD Patients with Anemia on Hemodialysis in Japan.

J Am Soc Nephrol 2020 Jun 3. Epub 2020 Jun 3.

Development Medical Science Urology and Nephrology, Astellas Pharma Europe B.V., Leiden, The Netherlands.

Background: Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor approved in China for dialysis-dependent CKD anemia.

Methods: This phase 3, 24-week, double-blind, double-dummy study evaluated roxadustat's noninferiority to darbepoetin alfa for hemodialysis-dependent CKD anemia. We randomly assigned Japanese patients to oral roxadustat three times weekly or to darbepoetin alfa injections once weekly, titrating doses to maintain hemoglobin between 10-12 g/dl. Read More

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http://dx.doi.org/10.1681/ASN.2019060623DOI Listing

Dynamic variations of the COVID-19 disease at different quarantine strategies in Wuhan and mainland China.

J Infect Public Health 2020 May 22. Epub 2020 May 22.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518000, China. Electronic address:

Background: The Coronavirus Disease 2019 (COVID-19) firstly announced in Wuhan of Hubei province, China is rapidly spreading to all the other 31 provinces of China and to more than 140 countries. Quarantine strategies play the key role on the disease controlling and public health in the world with this pandemic of the COVID-19 defined by the World Health Organization.

Methods: In this study, a SEIRQ epidemic model was developed to explore the dynamic changes of COVID-19 in Wuhan and mainland China, from January 27, 2020 to March 5, 2020. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.05.014DOI Listing

Risk factors for bat contact and consumption behaviors in Thailand; a quantitative study.

BMC Public Health 2020 Jun 3;20(1):841. Epub 2020 Jun 3.

Center of Excellence for Emerging and Re-emerging Infectious Diseases in Animals, Chulalongkorn University, Bangkok, Thailand.

Background: Bats serve as an important reservoir for emerging infectious diseases. Bat contact and consumption, which persists in Asia, poses risks for the transmission of bat-borne infections.

Methods: An analytical cross-sectional survey for risk factors associated with bat contact and consumption behaviors was conducted in ten provinces of Thailand from May 2016 to December 2017. Read More

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http://dx.doi.org/10.1186/s12889-020-08968-zDOI Listing

Productivity costs from a dengue episode in Asia: a systematic literature review.

BMC Infect Dis 2020 Jun 3;20(1):393. Epub 2020 Jun 3.

Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.

Background: Dengue is a mosquito-borne viral infection which has been estimated to cause a global economic burden of US$8.9 billion per year. 40% of this estimate was due to what are known as productivity costs (the costs associated with productivity loss from both paid and unpaid work that results from illness, treatment or premature death). Read More

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http://dx.doi.org/10.1186/s12879-020-05109-0DOI Listing

Emerging Challenges and Threats for Dental Health Care Sector Attributable to COVID-19: Tale of a Developing Country.

Asia Pac J Public Health 2020 Jun 4:1010539520932708. Epub 2020 Jun 4.

Hamdard University, Karachi, Pakistan.

Prevention and control of infection in dentistry is an essential matter that has gained immense attention in recent years. There exist a lack of scientific data about the cross-transmission and its associated risk, especially in the dental health care setting of Pakistan. This article will evaluate the emerging challenges and threats for the dental community in Pakistan attributable to the COVID-19 outbreak. Read More

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http://dx.doi.org/10.1177/1010539520932708DOI Listing

Characteristics of depressive symptoms in middle-aged family members of dementia patients: 2017 Korea Community Health Survey.

Epidemiol Health 2020 15;42:e2020031. Epub 2020 May 15.

Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objectives: The characteristics of depressive symptoms in the family members of home-dwelling patients with dementia have not been clearly reported. This study aimed to investigate the characteristics of depressive symptoms in middle-aged family members living with a patient with dementia.

Methods: This study used the data from the nationwide 2017 Korea Community Health Survey. Read More

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http://dx.doi.org/10.4178/epih.e2020031DOI Listing

Validation Study of Rajasekaran's Kyphosis Classification System: Do We Clearly Understand Single- and Two-Column Deficiencies?

Asian Spine J 2020 Jun 5. Epub 2020 Jun 5.

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Study Design: Multicenter validation study.

Purpose: To evaluate the inter-rater reliability of Rajasekaran's kyphosis classification through a multicenter validation study.

Overview Of Literature: The classification of kyphosis, developed by Rajasekaran, incorporates factors related to curve characteristics, including column deficiency, disc mobility, curve magnitude, and osteotomy requirements. Read More

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http://dx.doi.org/10.31616/asj.2020.0014DOI Listing

Improving Multi-Tumor Biomarker Health Check-up Tests with Machine Learning Algorithms.

Cancers (Basel) 2020 Jun 1;12(6). Epub 2020 Jun 1.

Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City 33305, Taiwan.

Background: Tumor markers are used to screen tens of millions of individuals worldwide at annual health check-ups, especially in East Asia. Machine learning (ML)-based algorithms that improve the diagnostic accuracy and clinical utility of these tests can have substantial impact leading to the early diagnosis of cancer.

Methods: ML-based algorithms, including a cancer screening algorithm and a secondary organ of origin algorithm, were developed and validated using a large real world dataset (RWD) from asymptomatic individuals undergoing routine cancer screening at a Taiwanese medical center between May 2001 and April 2015. Read More

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http://dx.doi.org/10.3390/cancers12061442DOI Listing

Resistin Enhances VCAM-1 Expression and Monocyte Adhesion in Human Osteoarthritis Synovial Fibroblasts by Inhibiting MiR-381 Expression through the PKC, p38, and JNK Signaling Pathways.

Cells 2020 Jun 1;9(6). Epub 2020 Jun 1.

School of Medicine, China Medical University, Taichung 404, Taiwan.

The development of osteoarthritis (OA) is characterized by synovial inflammation and the upregulation of vascular cell adhesion molecule type 1 (VCAM-1) in human osteoarthritis synovial fibroblasts (OASFs). This increase in VCAM-1 expression promotes monocyte adhesion to OASFs. The adipokine resistin is known to promote the release of inflammatory cytokines during OA progression. Read More

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http://dx.doi.org/10.3390/cells9061369DOI Listing

Rapid in-country sequencing of whole virus genomes to inform rabies elimination programmes.

Wellcome Open Res 2020 19;5. Epub 2020 May 19.

Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, G12 8QQ, UK.

Genomic surveillance is an important aspect of contemporary disease management but has yet to be used routinely to monitor endemic disease transmission and control in low- and middle-income countries. Rabies is an almost invariably fatal viral disease that causes a large public health and economic burden in Asia and Africa, despite being entirely vaccine preventable. With policy efforts now directed towards achieving a global goal of zero dog-mediated human rabies deaths by 2030, establishing effective surveillance tools is critical. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15518.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001756.2PMC

Clinical risk factors for the development of late-onset circulatory collapse in premature infants.

Pediatr Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA.

Background: Very low birth weight (VLBW) infants may be at risk for late-onset circulatory collapse (LCC) where otherwise stable infants develop hypotension resistant to vasoactive agents. The risk factors for LCC development are poorly defined, and it has been theorized that it may be in part due to withdrawal from exogenous prenatal steroids. The goal of this study was to define the clinical characteristics of LCC and investigate its association with antenatal steroid administration. Read More

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http://dx.doi.org/10.1038/s41390-020-0990-7DOI Listing

COVID-19's impact on the atmospheric environment in the Southeast Asia region.

Sci Total Environ 2020 May 25;736:139658. Epub 2020 May 25.

Department of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.

Since its first appearance in Wuhan, China at the end of 2019, the new coronavirus (COVID-19) has evolved a global pandemic within three months, with more than 4.3 million confirmed cases worldwide until mid-May 2020. As many countries around the world, Malaysia and other southeast Asian (SEA) countries have also enforced lockdown at different degrees to contain the spread of the disease, which has brought some positive effects on natural environment. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139658DOI Listing

Does COVID-19 infection impact on the trend of seasonal influenza infection? 11 countries and regions, from 2014 to 2020.

Int J Infect Dis 2020 May 31. Epub 2020 May 31.

Department of Healthcare Epidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan. Electronic address:

Objectives: Infection due to the 2019 novel coronavirus disease (COVID-19) is widespread dramatically around the world. This COVID-19 pandemic could increase public concern to prevent infectious disease. The present study aimed to assess the relationship between the COVID-19 epidemic and decreasing another infectious disease. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.088DOI Listing

Establishment of Recombinase Polymerase Amplification assay for rapid and sensitive detection of Orientia tsutsugamushi in Southeast Asia.

Acta Trop 2020 May 31:105541. Epub 2020 May 31.

Department of Genomics and Cytogenetics, Institute of Biomedicine and Pharmacy (IBP), Vietnam Military Medical University, Vietnam; Department of Medical Microbiology, The 103 Military Hospital, Vietnam Medical University, Vietnam. Electronic address:

Scrub typhus, caused by Orientia tsutsugamushi, is a common fever in parts of Southern and South East Asia. As delayed diagnosis of scrub typhus leads to inappropriate treatment and high mortality rates, of up to 70%, sensitive and rapid detection of O. tsutsugamushi is required for timely and appropriate treatment. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105541DOI Listing

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial.

JAMA 2020 Jun 3. Epub 2020 Jun 3.

Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.

Importance: Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed.

Objective: To evaluate the efficacy and adverse effects of convalescent plasma therapy for patients with COVID-19.

Design, Setting, And Participants: Open-label, multicenter, randomized clinical trial performed in 7 medical centers in Wuhan, China, from February 14, 2020, to April 1, 2020, with final follow-up April 28, 2020. Read More

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http://dx.doi.org/10.1001/jama.2020.10044DOI Listing

Acute malnutrition recovery energy requirements based on mid-upper arm circumference: Secondary analysis of feeding program data from 5 countries, Combined Protocol for Acute Malnutrition Study (ComPAS) Stage 1.

PLoS One 2020 3;15(6):e0230452. Epub 2020 Jun 3.

Department of Population Health & Centre for Maternal, Adolescent and Child Health (MARCH), London School of Hygiene and Tropical Medicine, London, England, United Kingdom.

Background: Severe and moderate acute malnutrition (SAM and MAM) are currently treated with different food products in separate treatment programs. The development of a unified and simplified treatment protocol using a single food product aims to increase treatment program efficiency and effectiveness. This study, the first stage of the ComPAS trial, sought to assess rate of growth and energy requirements among children recovering from acute malnutrition in order to design a simplified, MUAC-based dosage protocol. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230452PLOS

Isotopic interpretation of particulate nitrate in the metropolitan city of Karachi, Pakistan: Insight into the oceanic contribution to NOx.

Environ Sci Technol 2020 Jun 3. Epub 2020 Jun 3.

Nitrogen oxide (NOx) abatement has become the focus of air quality management strategies. In this study, we examined NOx sources and the atmospheric conversion of NOx in Karachi, Pakistan, a megacity in South Asia with serious particulate pollution problems. Oceanic contributions to NOx were quantified for the first time based on a novel approach using nitrogen/oxygen isotopic analysis in nitrate (δ15N-NO3-; δ18O-NO3-) and a Bayesian model. Read More

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http://dx.doi.org/10.1021/acs.est.0c00490DOI Listing

COVID-19 mortality rates in the European Union, Switzerland, and the UK: effect of timeliness, lockdown rigidity, and population density.

Minerva Med 2020 Jun 2. Epub 2020 Jun 2.

Hospital Universitario de la Princesa, Madrid, Spain -

Background: To date the European experience with COVID-19 mortality has been different to the observed in China and Asia. We aimed to forecast mortality trends in the 27 countries of the European Union (EU), plus Switzerland and the United Kingdom (UK), where lockdown dates and confinement interventions have been heterogeneous, and to explore its determinants.

Methods: We have adapted our predictive model of COVID-19-related mortality, which rested on the observed mortality within the first weeks of the outbreak and the date of the respective lockdown in each country. Read More

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http://dx.doi.org/10.23736/S0026-4806.20.06702-6DOI Listing

COVID-19-Related Information Sources and Their Relationships with Confidence of People in Coping with COVID-19: A Facebook Survey Study in Taiwan.

J Med Internet Res 2020 Jun 2. Epub 2020 Jun 2.

Department of Psychiatry, Kaohsiung Medical University, 100 Tzyou 1st road, Kaohsiung, TW.

Background: People obtain information on coronavirus disease 2019 (COVID-19) from the Internet and other sources. Understanding the factors related to such information sources aids health professionals in educating individuals.

Objective: This study used data collected from the Online Survey Study on COVID-19 in Taiwan to examine what major COVID-19 information sources are available and which sources are significantly related to the self-confidence of people in coping with COVID-19 in Taiwan. Read More

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http://dx.doi.org/10.2196/20021DOI Listing

Estimation of high-resolution PM2.5 over Indo-Gangetic Plain by fusion of satellite data, meteorology, and land use variables.

Environ Sci Technol 2020 Jun 3. Epub 2020 Jun 3.

Very high spatially resolved satellite-derived ground-level PM2.5 concentrations have multiple potential applications especially in air quality modelling, epidemiological and climatological research. Satellite-derived aerosol optical epth (AOD), and columnar water vapor (CWV), meteorological parameters, and land use data were used as variables within a linear mixed effect model (LME) and a random forest (RF) model, to predict daily ground-level concentrations of PM2. Read More

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http://dx.doi.org/10.1021/acs.est.0c01769DOI Listing

Mitochondrial ion channels as targets for cardioprotection.

J Cell Mol Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Biomedical Sciences, University of Padova, Padova, Italy.

Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the leading causes of death and disability worldwide. As such, new therapeutic targets need to be discovered to protect the myocardium against acute ischaemia/reperfusion (I/R) injury in order to reduce myocardial infarct (MI) size, preserve left ventricular function and prevent the onset of HF. Mitochondrial dysfunction during acute I/R injury is a critical determinant of cell death following AMI, and therefore, ion channels in the inner mitochondrial membrane, which are known to influence cell death and survival, provide potential therapeutic targets for cardioprotection. Read More

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http://dx.doi.org/10.1111/jcmm.15341DOI Listing

The State of Pediatric Research in Hawai'i: A Comparative Bibliometric Analysis.

Hawaii J Health Soc Welf 2020 May;79(5 Suppl 1):55-63

Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, HI.

The current state of pediatric research in Hawai'i was analyzed using bibliometric methods. The Web of Science bibliometric database was used to retrieve 989 Hawai'i records, which were compared with 264 064 records from the United States (US). Hawai'i was compared to the country as a whole in terms of total output of research, article types, top journals, co-authorship, and subject areas. Read More

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Data on Indicators used in Southeast Asian nations' 4th and 5th National Reports to the Convention on Biological Diversity.

Data Brief 2020 Aug 15;31:105705. Epub 2020 May 15.

ASEAN Centre for Biodiversity, Domingo M. Lantican Avenue, Los Baños, Laguna 4031, Philippines.

The data presented in this article are related to the research article entitled "Progress on National Biodiversity Indicator Reporting and Prospects for Filling Indicator Gaps in Southeast Asia " (Han et al., 2020). We examined quantifiable information about biodiversity indicators from the most recent two national reports (i. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262426PMC

Prenatal screening of DiGeorge (22q11.2 deletion) syndrome by abnormalities of the great arteries among Thai pregnant women.

Obstet Gynecol Sci 2020 May 14;63(3):330-336. Epub 2020 Apr 14.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objective: 22q11.2DS (deletion syndrome) is one of the common serious anomalies resulting in high perinatal morbidity and mortality rate. Nevertheless, prenatal diagnosis of 22q11. Read More

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http://dx.doi.org/10.5468/ogs.2020.63.3.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231935PMC

Localized infection presenting as a tonsillar mass mimicking malignancy.

IDCases 2020 16;21:e00824. Epub 2020 May 16.

Section of Infectious Diseases, Department of Internal Medicine, University of Missouri Kansas City, Kansas City, MO, United States.

is an opportunistic fungal infection seen in immunocompromised patients including those with HIV/AIDS. It is usually seen in patients who live in or are from tropical Asia. In HIV patients, oropharyngeal and laryngeal lesions are usually part of disseminated infection. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256294PMC

Establishment of a Percutaneous Coronary Intervention Registry in Vietnam: Rationale and Methodology.

Glob Heart 2020 Apr 8;15(1):30. Epub 2020 Apr 8.

School of Public Health, Curtin University, Perth, AU.

Background: In lower- and middle-income countries across Asia there has been a rapid expansion and uptake of percutaneous coronary intervention (PCI). However, there has been limited routine collection of related data, particularly around quality, safety and cost. The aim of this study was to assess the viability of implementing routine collection of PCI data in a registry at a leading hospital in Hanoi, Vietnam. Read More

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http://dx.doi.org/10.5334/gh.782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218793PMC

A report of the Social Vital Signs Workshop at WONCA Asia Pacific Regional Conference 2019.

J Gen Fam Med 2020 May 18;21(3):92-93. Epub 2020 Feb 18.

Division of Medical Education Faculty of Medicine Juntendo University Tokyo Japan.

We, Team SAIL, held the workshop at WONCA APR Conference 2019 for presenting the concept of Social Vital Signs (SVS) to an international audience. Read More

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http://dx.doi.org/10.1002/jgf2.304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260155PMC

Empiric Treatment for Suspected Malaria in the United States: A Case Report.

Cureus 2020 Apr 29;12(4):e7885. Epub 2020 Apr 29.

Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, USA.

Malaria in the United States is rare and most commonly presents among returning travelers from endemic areas. Diagnosis is classically dependent on a positive blood smear or polymerase chain reaction (PCR) test. The objective of this case report is to highlight a case of suspected malaria in a high-risk individual with negative diagnostic testing where a trial of empiric treatment was initiated based on clinical presentation after a thorough discussion of risks and benefits. Read More

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http://dx.doi.org/10.7759/cureus.7885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255543PMC

Climate change-induced migration patterns and extinction risks of Theaceae species in China.

Ecol Evol 2020 May 31;10(10):4352-4361. Epub 2020 Mar 31.

State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental Sciences Beijing China.

Theaceae, an economically important angiosperm family, is widely distributed in tropical and subtropical forests in Asia. In China, Theaceae has particularly high abundances and endemism, comprising ~75% of the total genera and ~46% of the total species worldwide. Therefore, predicting the response of Theaceae species to climate change is vital. Read More

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http://dx.doi.org/10.1002/ece3.6202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246209PMC

Different processes shape the patterns of divergence in the nuclear and chloroplast genomes of a relict tree species in East Asia.

Ecol Evol 2020 May 24;10(10):4331-4342. Epub 2020 Mar 24.

State Key Laboratory of Earth Surface Processes and Resource Ecology and Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life Sciences Beijing Normal University Beijing China.

Isolation by spatial distance (IBD), environment (IBE), and historical climatic instability (IBI) are three common processes assessed in phylogeographic and/or landscape genetic studies. However, the relative contributions of these three processes with respect to spatial genetic patterns have seldom been compared. Moreover, whether the relative contribution differs in different regions or when assessed using different genetic markers has rarely been reported. Read More

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http://dx.doi.org/10.1002/ece3.6200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246201PMC
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