806,531 results match your criteria Asia Pacific Journal Of Education[Journal]


Antimicrobial-resistant Gram-negative colonisation in infants from a NICU in Thailand.

J Hosp Infect 2019 Apr 14. Epub 2019 Apr 14.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalised neonates in South and South-East Asia. We aimed to determine the dynamics of colonisation with antimicrobial-resistant Gram-negative bacteria amongst infants in a neonatal intensive care unit (NICU) in Thailand. From a total of 97 enrolled infants, 52% of neonates were colonised by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonised by a carbapenem-resistant organism. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.04.004DOI Listing

Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption.

N Engl J Med 2019 Apr;380(16):1535-1545

From United Biomedical, Hauppauge, NY (C.-Y.W., B.-S.K., C.L.F., F.W.-S.); United Biomedical Asia (C.-Y.W., S.L.) and United BioPharma (C.-Y.W., B.-S.K., H.-W.S., C.-Y.L., F.-C.T., A.L., F.-H.Y., C.-H.L., W.T., M.-J.L.), Hsinchu, Taipei Veterans General Hospital, Taipei (W.-W.W., H.-Y.L.), and Kaohsiung Veterans General Hospital (H.-C.T.) and Kaohsiung Medical University Hospital (Y.-H.C.), Kaohsiung - all in Taiwan; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (J.B., K.E.C., T.-W.C.); and the California Department of Public Health, Richmond (C.V.H.).

Background: Administration of a single broadly neutralizing human immunodeficiency virus (HIV)-specific antibody to HIV-infected persons leads to the development of antibody-resistant virus in the absence of antiretroviral therapy (ART). It is possible that monotherapy with UB-421, an antibody that blocks the virus-binding site on human CD4+ T cells, could induce sustained virologic suppression without induction of resistance in HIV-infected persons after analytic treatment interruption.

Methods: We conducted a nonrandomized, open-label, phase 2 clinical study evaluating the safety, pharmacokinetics, and antiviral activity of UB-421 monotherapy in HIV-infected persons undergoing analytic treatment interruption. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1802264
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http://dx.doi.org/10.1056/NEJMoa1802264DOI Listing
April 2019
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Geographic expansion of artemisinin resistance.

J Travel Med 2019 Apr 17. Epub 2019 Apr 17.

Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: Artemisinin-based combination therapy (ACT) is the global standard of care for uncomplicated falciparum malaria. First reports of ACT resistance came from western Cambodia and the Thailand-Cambodia border in 2002-2004. The subsequent emergence and expansion of P. Read More

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http://dx.doi.org/10.1093/jtm/taz030DOI Listing

Malaria Standby Emergency Treatment (SBET) for Travelers Visiting Malaria Endemic Areas: a Systematic Review and Meta-Analysis.

J Travel Med 2019 Apr 17. Epub 2019 Apr 17.

Department of research, innovation and training, Unisanté, Center for Primary Care and Public Health, University of Lausanne, Switzerland.

Malaria prevention methods for travelers to low or moderate malaria risk areas varies and remains controversial. Standby Emergency Treatment (SBET) for malaria is one possible strategy increasingly recommended since 1988 with little evidence on its effectiveness or how it is truly being used. A systematic review and meta-analysis were performed based on a structured search in Embase, Medline, PubMed, Cochrane, and Web of Science on September 7, 2018. Read More

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http://dx.doi.org/10.1093/jtm/taz027DOI Listing

Evolutionary history of burrowing asps (Lamprophiidae: Atractaspidinae) with emphasis on fang evolution and prey selection.

PLoS One 2019 17;14(4):e0214889. Epub 2019 Apr 17.

Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America.

Atractaspidines are poorly studied, fossorial snakes that are found throughout Africa and western Asia, including the Middle East. We employed concatenated gene-tree analyses and divergence dating approaches to investigate evolutionary relationships and biogeographic patterns of atractaspidines with a multi-locus data set consisting of three mitochondrial (16S, cyt b, and ND4) and two nuclear genes (c-mos and RAG1). We sampled 91 individuals from both atractaspidine genera (Atractaspis and Homoroselaps). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214889PLOS
April 2019
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A new hadrosauroid (Dinosauria: Ornithopoda) from the Late Cretaceous Baynshire Formation of the Gobi Desert (Mongolia).

PLoS One 2019 17;14(4):e0208480. Epub 2019 Apr 17.

Department of Geosciences, Faculty of Science, Osaka City University, Osaka Prefecture, Osaka, Japan.

A new genus and species of non-hadrosaurid hadrosauroid, Gobihadros mongoliensis, is described from a virtually complete and undeformed skull and postcranial skeleton, as well as extensive referred material, collected from the Baynshire Formation (Cenomanian-Santonian) of the central and eastern Gobi Desert, Mongolia. Gobihadros mongoliensis is the first non-hadrosaurid hadrosauroid from the Late Cretaceous of central Asia known from a complete, articulated skull and skeleton. The material reveals the skeletal anatomy of a proximate sister taxon to Hadrosauridae in remarkable detail. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208480PLOS

Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission.

PLoS Negl Trop Dis 2019 Apr 17;13(4):e0007343. Epub 2019 Apr 17.

Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities; St. Paul, MN, United States of America.

Congenital Zika virus (ZIKV) infection was first linked to birth defects during the American outbreak in 2015/2016. It has been proposed that mutations unique to the Asian/American-genotype explain, at least in part, the ability of Asian/American ZIKV to cause congenital Zika syndrome (CZS). Recent studies identified mutations in ZIKV infecting humans that arose coincident with the outbreak in French Polynesia and were stably maintained during subsequent spread to the Americas. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007343DOI Listing

Factors influencing engagement in premarital sex among Vietnamese young adults: a qualitative study.

Int J Adolesc Med Health 2019 Apr 17. Epub 2019 Apr 17.

Bournemouth University, Faculty of Health and Social Sciences, Bournemouth House, Bournemouth, BH21 3UJ, UK.

Background With the rising trend of sexual engagement among Vietnamese young adults in recent years, concerns were raised over the issue of premarital sex and its potential health consequences. In order to prevent such consequences and further promote health, an in-depth understanding of factors influencing young people to have premarital sex would be valuable. Objective To generate a grounded theory explaining factors influencing engagement in premarital sex among Vietnamese young adults. Read More

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http://dx.doi.org/10.1515/ijamh-2018-0201DOI Listing

Patient-Reported and Functional Outcomes After Revision Amputation and Replantation of Digit Amputations: The FRANCHISE Multicenter International Retrospective Cohort Study.

JAMA Surg 2019 Apr 17. Epub 2019 Apr 17.

Research and Scientific Affairs, The Plastic Surgery Foundation, Arlington Heights, Illinois.

Importance: Optimal treatment for traumatic digit amputation is unknown.

Objective: To compare long-term patient-reported and functional outcomes between patients treated with revision amputation or replantation for digit amputations.

Design, Setting, And Participants: Retrospective cohort study at 19 centers in the United States and Asia. Read More

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http://dx.doi.org/10.1001/jamasurg.2019.0418DOI Listing

Historical Black Carbon Reconstruction from the Lake Sediments of the Himalayan - Tibetan Plateau.

Environ Sci Technol 2019 Apr 17. Epub 2019 Apr 17.

Black Carbon (BC) is one of the major drivers of climate change and its measurement in different environment is crucial for better understanding of long-term trend in Himalayan-Tibetan Plateau (HTP) as climate warming has intensified in the region. We present measurement of BC concentration from six lake sediments in HTP to reconstruct historical BC deposition since the preindustrial era. Our results show an increasing trend of BC, concurrent with increased anthropogenic emission pattern after the commencement of an industrialization era during the 1950s. Read More

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http://dx.doi.org/10.1021/acs.est.8b07025DOI Listing

Elevated Human Crimean-Congo Hemorrhagic Fever Virus Seroprevalence in Khashm el Girba, Eastern Sudan.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Institute for Virology, University Clinics and Medical Faculty, University of Leipzig, Leipzig, Germany.

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that can evolve into deadly hemorrhagic fever and that is endemic in many parts of Europe, Middle East, Central Asia, and Africa. Because of several reports about CCHF outbreaks in the south of Sudan during the last years, we examined in this study if unrecognized CCHF-V infections also occurred in the eastern and central parts of the country. The study examined the seroprevalence of CCHF virus infection in 464 sera from three regions of Sudan without previous reports of CCHF infection. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0977DOI Listing

The Investment Case for Malaria Elimination in Thailand: A Cost-Benefit Analysis.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

RTI International, Washington, District of Columbia.

After a dramatic decline in the annual malaria incidence in Thailand since 2000, the Thai government developed a National Malaria Elimination Strategy (NMES) to end local malaria transmission by 2024. This study examines the expected costs and benefits of funding the NMES (elimination scenario) versus not funding malaria elimination programming (resurgence scenario) from 2017 to 2036. Two case projection approaches were used to measure the number of malaria cases over the study period, combined with a set of Thailand-specific economic assumptions, to evaluate the cost of a malaria case and to quantify the cost-benefit ratio. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0897DOI Listing

A Prospective Study on the Impact and Out-of-Pocket Costs of Dengue Illness in International Travelers.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Although the costs of dengue illness to patients and households have been extensively studied in endemic populations, international travelers have not been the focus of costing studies. As globalization and human travel activities intensify, travelers are increasingly at risk for emerging and reemerging infectious diseases, such as dengue. This exploratory study aims to investigate the impact and out-of-pocket costs of dengue illness among travelers. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0780DOI Listing

A Simple Solution That Saves Lives: Overcoming Diarrheal Disease in the Age of Universal Health Coverage.

Asia Pac J Public Health 2018 Oct;30(7):604-606

2 Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1177/1010539518809444DOI Listing
October 2018

Paraquat Exposure Through Breast-feeding.

Asia Pac J Public Health 2018 Oct;30(7):673-674

3 Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 10400.

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http://dx.doi.org/10.1177/1010539518808847DOI Listing
October 2018

Commentary: Hazards of Agricultural Chemicals and the Benefits of an Occupational Health Education Program for Thai Farmers.

Asia Pac J Public Health 2018 Oct;30(7):607-609

2 Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1177/1010539518808956DOI Listing
October 2018

Co-infection of peste des petits ruminants and goatpox in a mixed flock of sheep and goats in Kanam, North Central Nigeria.

Vet Med Sci 2019 Apr 17. Epub 2019 Apr 17.

Central Diagnostic Laboratory, National Veterinary Research Institute, Vom, Nigeria.

Peste-des-petits-ruminants (PPR) and Goat pox (GTP) are two devastating and economically important transboundary animal diseases of small ruminants in Africa and Asia that have been difficult to control. This study however, investigated an outbreak of PPR and GTP in a mixed flock of indigenous sheep and goats in Kanam, North Central Nigeria. A total of nine sera and seven tissues (lungs, spleen, scab and skin) samples were collected and analysed in the laboratory using competitive enzyme linked immunosorbent assay (cELISA) for PPR antibodies and polymerase chain reaction (PCR) for detection of PPR virus (PPRV) and GTP virus (GTPV). Read More

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http://dx.doi.org/10.1002/vms3.170DOI Listing

Effect of genetic variants in cell adhesion pathways on the biochemical recurrence in prostate cancer patients with radical prostatectomy.

Cancer Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacy, China Medical University, Taichung, Taiwan.

The aberrant expression of cell adhesion molecules is a hallmark of epithelial-to-mesenchymal transition, resulting in the transformation of cancer cells to a more aggressive phenotype. This study investigated the association between genetic variants in cell adhesion pathways and the prognosis of patients with prostate cancer following radical prostatectomy (RP). A total of 18 haplotype-tagging single-nucleotide polymorphisms (SNPs) in eight cancer-related adhesion molecules were genotyped in 458 prostate cancer patients, followed by the replication of the top SNPs in an additional set of 185 patients. Read More

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http://dx.doi.org/10.1002/cam4.2163DOI Listing

Stress and other factors associated with colorectal cancer outpatients with temporary colostomies.

Eur J Cancer Care (Engl) 2019 Apr 16:e13054. Epub 2019 Apr 16.

National Cheng Kung University Hospital, Tainan City, Taiwan.

This study investigated stress and other factors associated with colorectal cancer (CRC) outpatients with temporary colostomies in Taiwan. Temporary colostomies have been incorporated as a defecation alternative to maintain physical function and are accompanied by chemotherapy/radiotherapy in CRC patients. A cross-sectional study was conducted, and a convenience sampling approach was adopted to recruit 110 discharged CRC patients with temporary colostomies from a medical centre in southern Taiwan. Read More

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http://dx.doi.org/10.1111/ecc.13054DOI Listing

Does drug-induced sleep endoscopy affect surgical outcome? A multicenter study of 326 obstructive sleep apnea patients.

Laryngoscope 2019 Apr 17. Epub 2019 Apr 17.

Otolaryngology Department, Western University, London, Ontario, Canada.

Objectives/hypothesis: Our objective was to determine whether drug-induced sleep apnea (DISE) affects the successfulness of the surgical outcome.

Study Design: Prospective, seven-country, nonrandomized trial.

Methods: There were 326 consecutive obstructive sleep apnea (OSA) patients who had nose, palate, and/or tongue surgery included in the study. Read More

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http://dx.doi.org/10.1002/lary.27987DOI Listing

Vaccines for emerging pathogens: from research to the clinic.

Authors:
E D Williamson

Clin Exp Immunol 2019 May;196(2):155-156

Defence Science and Technology Laboratory, Porton Down, Salisbury, UK.

In this two-part series of reviews, we have invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens. This topic has been brought into sharp focus in recent years following significant outbreaks of viral diseases such as those causing severe acute respiratory syndrome and Middle East respiratory syndrome, as well as devastating outbreaks of diseases caused by the Ebola, Marburg, Zika and Lassa fever viruses, to name only a few examples. Additionally, bacterial infections leading to bubonic and pneumonic plague, most notably in Madagascar in 2018, as well as malaria in many tropical countries, melioidosis in south east Asia and tularaemia in northern Europe and North America, have incurred significant morbidity and mortality. Read More

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http://doi.wiley.com/10.1111/cei.13303
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http://dx.doi.org/10.1111/cei.13303DOI Listing
May 2019
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Molecular phylogenetic species delimitation in the aquatic genus Ottelia (Hydrocharitaceae) reveals cryptic diversity within a widespread species.

J Plant Res 2019 Apr 16. Epub 2019 Apr 16.

Kadoorie Farm and Botanic Garden, Lam Kam Road, Tai Po, Hong Kong, People's Republic of China.

Ottelia, a pantropical genus of aquatic plants belonging to the family Hydrocharitaceae, includes several narrowly distributed taxa in Asia. Although the Asian species have received comparatively more research attention than congeners in other areas, various key taxonomic questions remain unaddressed, especially with regards to apparent cryptic diversity within O. alismoides, a widespread species complex native to Asia, northern Australia and tropical Africa. Read More

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http://dx.doi.org/10.1007/s10265-019-01109-7DOI Listing

Distribution and Ecological Drivers of Spotted Fever Group Rickettsia in Asia.

Ecohealth 2019 Apr 15. Epub 2019 Apr 15.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithee Road, Bangkok, 10400, Thailand.

Spotted fever group and related rickettsia (SFGR) are a neglected group of pathogens that belong to the genus Rickettsia. SFGR are zoonotic and are transmitted by arthropod vectors, primarily ticks, fleas and mites to accidental hosts. These emerging and re-emerging infections are widely distributed throughout the world. Read More

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http://link.springer.com/10.1007/s10393-019-01409-3
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http://dx.doi.org/10.1007/s10393-019-01409-3DOI Listing
April 2019
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A unilateral less invasive posterolateral approach for disc debridement and titanium cage insertion supplemented by contralateral transfascial screw fixation for high-morbidity patients suffering from septic thoracolumbosacral spondylodiscitis.

Eur J Orthop Surg Traumatol 2019 Apr 16. Epub 2019 Apr 16.

AMR Advanced Medical Research GmbH, Hofenstrasse 89b, 8708, Männedorf, Switzerland.

Purpose: This case series reports on the efficacy and safety of a less invasive posterolateral approach for septic thoracolumbosacral spondylodiscitis in high-morbidity patients.

Methods: Twenty consecutive severe sick (ASA > III) patients (14 men and 6 women), with an average age of 64 ± 14 years, suffering from septic subacute and chronic thoracolumbosacral spondylodiscitis were selected to undergo a one-stage less invasive unilateral posterolateral disc space debridement, supplemented by an ipsilateral titanium cage implantation and pedicle screw fixation plus a contralateral transfascial pedicle screw fixation.

Results: Two high-risk patients with severe comorbidities (ASA stage IV and V, respectively) died on days 1 and 8 postoperatively because of non-surgical complications such as massive lung embolism and acute myocardial infract, respectively. Read More

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http://link.springer.com/10.1007/s00590-019-02434-2
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http://dx.doi.org/10.1007/s00590-019-02434-2DOI Listing
April 2019
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Dietary Patterns and Determinants of Changing Diets in Bangladesh from 1985 to 2010.

Curr Dev Nutr 2019 Apr 21;3(4):nzy091. Epub 2018 Nov 21.

Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany.

Background: The government of Bangladesh has implemented multiple policies since 1971 to provide the population with more diverse and nutritious diets.

Objective: The aim of this study was to examine the drivers of dietary change over time and the roles agriculture and economic development have played.

Methods: We used principal component analysis to derive dietary patterns from 7 cross-sectional rounds of the Bangladesh Household [Income and] Expenditure Survey. Read More

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http://dx.doi.org/10.1093/cdn/nzy091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459985PMC

Safety and Efficacy of Reduced Prolonged-release Tacrolimus Exposure in De Novo Kidney Transplantation: A Randomized, Open-label, Pilot Study in Asia-OPTIMIZE Study.

Transplant Direct 2019 Apr 25;5(4):e340. Epub 2019 Mar 25.

Division of Kidney and Pancreas Transplant, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: A multicenter, randomized, open-label, parallel group, pilot, 52-week study in Asian countries that assessed the renal function, efficacy, and safety of reduced-exposure versus standard-exposure prolonged-release tacrolimus (PR-T) in adult kidney transplant recipients (KTRs).

Methods: Posttransplantation, KTRs received PR-T from weeks 0 to 4 (initial dose, 0.2-0. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445651PMC

Recurrent Cough and Expectoration for 10 Years: A Case Report.

Glob Pediatr Health 2019 4;6:2333794X19833725. Epub 2019 Apr 4.

The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China.

. Most cases of cystic fibrosis occur in Europe, with only a few occurring in Asia. Pulmonary cystic fibrosis is not a rare disease, but in children it is a potentially life-threatening condition. Read More

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http://journals.sagepub.com/doi/10.1177/2333794X19833725
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http://dx.doi.org/10.1177/2333794X19833725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449808PMC
April 2019
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Salivary is a gender-difference biomarker of oral squamous cell carcinoma.

PeerJ 2019 9;7:e6732. Epub 2019 Apr 9.

Department of Healthcare Administration, Asia University, Taichung, Taiwan.

Background: The X-linked tumor suppressor gene is reported to be involved in oral cancer. The detection of biomarkers in salivary RNA is a non-invasive strategy for diagnosing many diseases. The aim of the present study was to investigate the potential of salivary as a biomarker of oral cancer. Read More

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http://dx.doi.org/10.7717/peerj.6732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461027PMC

Evolutionary and Genomic Insights into Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health Importance.

MBio 2019 Apr 16;10(2). Epub 2019 Apr 16.

Medical, Molecular and Forensic Sciences, Murdoch University, Western Australia, Australia

() sequence type 11 (ST11) is well established in production animal populations worldwide and contributes considerably to the global burden of infection (CDI) in humans. Increasing evidence of shared ancestry and genetic overlap of PCR ribotype 078 (RT078), the most common ST11 sublineage, between human and animal populations suggests that CDI may be a zoonosis. We performed whole-genome sequencing (WGS) on a collection of 207 ST11 and closely related ST258 isolates of human and veterinary/environmental origin, comprising 16 RTs collected from Australia, Asia, Europe, and North America. Read More

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http://dx.doi.org/10.1128/mBio.00446-19DOI Listing

Designing a comprehensive Non-Communicable Diseases (NCD) programme for hypertension and diabetes at primary health care level: evidence and experience from urban Karnataka, South India.

BMC Public Health 2019 Apr 16;19(1):409. Epub 2019 Apr 16.

Karnataka Health Promotion Trust, Bangalore, India.

Background: India accounts for more than two-third of mortality due to non-communicable diseases (NCDs) in south-east Asia. The burden is high in Karnataka, one of the largest states in southern India. There is a need for integration of disease prevention, health promotion, treatment and care within the national program at primary level. Read More

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http://dx.doi.org/10.1186/s12889-019-6735-zDOI Listing

Modelling global river export of microplastics to the marine environment: Sources and future trends.

Sci Total Environ 2019 Apr 8;673:392-401. Epub 2019 Apr 8.

Department of Science, Faculty of Management, Science & Technology, Open University, Heerlen, the Netherlands; Water Systems and Global Change Group, Wageningen University & Research, Wageningen, the Netherlands.

Microplastics, transported by rivers to oceans, are triggering environmental concern. This study aims to better understand river export of microplastics from land to sea. We developed the Global Riverine Export of Microplastics into Seas (GREMiS) model, a global, spatially explicit model for analysing the annual microplastics export to coastal seas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193159
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.078DOI Listing
April 2019
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The in vitro and in vivo depigmenting activity of Coenzyme Q10 through the down-regulation of α-MSH signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated skin keratinocytes.

Biochem Pharmacol 2019 Apr 13. Epub 2019 Apr 13.

Institute of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan. Electronic address:

Coenzyme CoQ10 (CoQ10), a ubiquinone compound, has been reported to inhibit tyrosinase activity and melanin production in melanoma B16F10 cells. However, the molecular mechanism underlying this inhibitory effect is poorly understood. In this paper we aimed to investigate the molecular mechanisms involved in the anti-melanogenic activity of CoQ10 (1-2 μM) in UVA (5 J/cm)-irradiated keratinocyte HaCaT cells and α-MSH stimulated B16-F10 cells. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.04.015DOI Listing

Correlation between the protein expression levels of A-kinase anchor protein95, p-retinoblastoma (Ser780), cyclin D2/3, and cyclin E2 in esophageal cancer tissues.

Asia Pac J Clin Oncol 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen Fujian, China.

Aim: This study aimed to investigate the correlation between the expression of A-kinase anchor protein95 (AKAP95), p-retinoblastoma (phosphorylated Rb, p-Rb), cyclin D2, cyclin D3 and cyclin E2 in esophageal cancer tissues and clinicopathological indexes.

Method: The protein expression levels of AKAP95, p-Rb, cyclin D2/3 and cyclin E2 in 40 esophageal cancer tissues were detected using immunohistochemistry, and the correlation between them was analyzed.

Result: The percentage of p-Rb (Ser780)-, cyclin D2-, cyclin D3- and cyclin E2-positive samples was 62. Read More

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http://dx.doi.org/10.1111/ajco.13146DOI Listing

Optimal Blood Pressure Goals Recommended by the Latest Hypertension Guidelines: India may benefit the most.

Eur Heart J 2018 Sep;39(33):3012-3016

Apollo Institute for Blood Pressure Management World Hypertension League/South Asia Office Apollo Hospitals, and Apollo Medical College Hyderabad, India, and Texas Blood Pressure Institute, DNA UTSW Medical School, Dallas, U.S.A and India Campus, Macquarie University, Medical School, Sydney, Australia.

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http://dx.doi.org/10.1093/eurheartj/ehy494DOI Listing
September 2018

Rapid determination of kappa-carrageenan using a biosensor from immobilized Pseudomonas carrageenovora cells.

PLoS One 2019 16;14(4):e0214580. Epub 2019 Apr 16.

Southeast Asia Disaster Prevention Research Initiative (SEADPRI-UKM), LESTARI, Universiti Kebangsaan Malaysia, UKM Bangi, Selangor Darul Ehsan, Malaysia.

A potentiometric whole cell biosensor based on immobilized marine bacterium, Pseudomonas carrageenovora producing κ-carrageenase and glycosulfatase enzymes for specific and direct determination of κ-carrageenan, is described. The bacterial cells were immobilized on the self-plasticized hydrogen ion (H+)-selective acrylic membrane electrode surface to form a catalytic layer. Hydrogen ionophore I was incorporated in the poly(n-butyl acrylate) [poly(nBA)] as a pH ionophore. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214580PLOS

Detecting spatio-temporal hotspots of scarlet fever in Taiwan with spatio-temporal Gi* statistic.

PLoS One 2019 16;14(4):e0215434. Epub 2019 Apr 16.

Research Center for Humanities and Social Sciences, Academia Sinica, Taipei, Taiwan.

A resurgence of scarlet fever has caused many pediatric infections in East Asia and the United Kingdom. Although scarlet fever in Taiwan has not been a notifiable infectious disease since 2007, the comprehensive national health insurance data can still track its trend. Here, we used data from the open data portal of the Taiwan Centers for Disease Control. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215434PLOS
April 2019
2 Reads

[Application of DNA metabarcoding technology in identification of Chinese patent medicines].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):261-264

School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University Kunming 650500,China.

Metabarcoding technology is a research method derived from the combination of traditional DNA barcodes and highthroughput sequencing technologies. It can quickly,easily and efficiently identify and restore biological samples from multiple species.Biological species are currently widely used in environmental biology research. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181106.006DOI Listing
January 2019

Get With The Guidelines - Management Of COPD In EDs In Europe And Australasia is sub-optimal.

Intern Med J 2019 Apr 15. Epub 2019 Apr 15.

Tours University Hospital, Emergency Medicine Department, 37044, Tours, France and François-Rabelais University, School of Medicine, 37044, Tours, France.

Objectives: Exacerbations of chronic obstructive pulmonary disease (COPD) are common in emergency departments (ED). Guidelines recommend administration of inhaled bronchodilators, systemic corticosteroids and antibiotics along with non-invasive ventilation (NIV) for patients with respiratory acidosis. We aimed to determine compliance with guideline recommendations for patients with treated for COPD in ED in Europe (EUR) and South East Asia/Australasia (SEA) and to compare management and outcomes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14323
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http://dx.doi.org/10.1111/imj.14323DOI Listing
April 2019
3 Reads

Characterization of gelsevirine metabolites in rat liver S9 by accurate mass measurements using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

Rapid Commun Mass Spectrom 2019 Apr 15. Epub 2019 Apr 15.

College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, 410128, China.

Rationale: Gelsemium elegans Benth belongs to the family Loganiaceae and is widely distributed in Northern America, East Asia, and Southeast Asia. It has attracted wide attention for its diverse biological effects and complex architectures. Gelsevirine is one of the major components in G. Read More

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http://dx.doi.org/10.1002/rcm.8457DOI Listing

Reproductive interference by alien hornet Vespa velutina threatens the native populations of Vespa simillima in Japan.

Naturwissenschaften 2019 Apr 13;106(5-6):15. Epub 2019 Apr 13.

Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo, Motoyama, Kita-ku, Kyoto, Japan.

The yellow-legged hornet Vespa velutina has become one of the major alien species in European and East Asian countries. As in its homeland, the invading V. velutina is reported as the major predator of honeybees and is becoming a threat to beekeeping in Europe. Read More

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http://dx.doi.org/10.1007/s00114-019-1609-xDOI Listing

Forensic performance of 30 InDels included in the Investigator DIPplex system in Miao population and comprehensive genetic relationship in China.

Int J Legal Med 2019 Apr 15. Epub 2019 Apr 15.

School of Public Health, Zunyi Medical University, Zunyi, 563099, Guizhou, China.

Binary markers of insertion and deletion (InDel) play an important role in forensic personal identification, parentage testing, and individual ancestry inference. We first genotyped 30 InDels included in the Investigator DIPplex in 403 unrelated healthy Zunyi Miao people and analyzed the genetic polymorphisms, as well as explored the genetic relationship between Miao and 32 Chinese reference populations. No departures from the HWE were observed. Read More

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http://dx.doi.org/10.1007/s00414-019-02057-6DOI Listing

A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong District of Seoul, Korea in 1986-2015.

J Crohns Colitis 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background And Aims: Although the incidence of inflammatory bowel disease (IBD) is increasing in Asia, data on long-term epidemiologic trends are limited. We performed a 30-year longitudinal study to investigate temporal trends in the epidemiology of Crohn's disease (CD) and ulcerative colitis (UC) in Seoul, Korea.

Methods: This population-based study included 1431 IBD patients (418 CD, 1013 UC) diagnosed between 1986 and 2015 in the Songpa-Kangdong district of Seoul, Korea. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz081DOI Listing

Effects of short-term acupuncture treatment on occlusal force and mandibular movement in patients with deep-bite malocclusion.

J Dent Sci 2019 Mar 4;14(1):81-86. Epub 2018 Dec 4.

School of Dentistry, China Medical University, No. 91 Hsueh-Shih Rd., Taichung 40402, Taiwan.

Background/purpose: Acupuncture is well known to be effective for pain relief and muscle relaxation, and hence it is feasible that acupuncture treatment could change the occlusal forces and mandibular movements in subjects with deep-bite malocclusion. The purpose of this research was to determine the distribution of occlusal force and the border movement of the mandible in patients with deep-bite malocclusion before and after acupuncture treatment.

Materials And Methods: This study involved 17 volunteers with deep-bite malocclusion and aged 20-30 years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19917902183079
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http://dx.doi.org/10.1016/j.jds.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445974PMC
March 2019
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The prevalence of Passavant's ridge in patients with velopharyngeal insufficiency in a Taiwan Chinese population.

J Dent Sci 2019 Mar 27;14(1):15-20. Epub 2018 Nov 27.

Department of Stomatology, Taichung Veterans General Hospital, Taichung, Taiwan.

Background/purpose: The Passavant's ridge can be utilized as a guide landmark during obturator prosthesis fabrication, but there were no studies concerning about the prevalence of the ridge in East Asia region. The purpose of this study was to evaluate the occurrence of Passavant's ridge in patients with velopharyngeal insufficiency in a Taiwan Chinese population.

Materials And Methods: It's a retrospective study that 91 patients with velopharyngeal insufficiency who received a obturator prosthesis during the period from 1992 to 2016 in Taichung Veterans General Hospital (TCVGH, Taiwan) were included. Read More

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http://dx.doi.org/10.1016/j.jds.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446019PMC

Systematic assessment of the sex ratio at birth for all countries and estimation of national imbalances and regional reference levels.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003-9304.

The sex ratio at birth (SRB; ratio of male to female live births) imbalance in parts of the world over the past few decades is a direct consequence of sex-selective abortion, driven by the coexistence of son preference, readily available technology of prenatal sex determination, and fertility decline. Estimation of the degree of SRB imbalance is complicated because of unknown SRB reference levels and because of the uncertainty associated with SRB observations. There are needs for reproducible methods to construct SRB estimates with uncertainty, and to assess SRB inflation due to sex-selective abortion. Read More

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http://dx.doi.org/10.1073/pnas.1812593116DOI Listing

Climate change and educational attainment in the global tropics.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Department of Geography, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

Climate change may negatively impact education among children via exposure to extreme temperature and precipitation conditions. We link census data from 29 countries across the global tropics to high-resolution gridded climate data to understand how climatic conditions experienced in utero and during early childhood affect educational attainment at ages 12 to 16. We show that exposure to higher-than-average temperatures during the prenatal and early-life period is associated with fewer years of schooling in Southeast Asia. Read More

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http://dx.doi.org/10.1073/pnas.1817480116DOI Listing
April 2019
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The world-wide burden of musculoskeletal diseases: a systematic analysis of the World Health Organization Burden of Diseases Database.

Ann Rheum Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Rheumatology - Centre National de Référence des Maladies Systémiques Rares Est Sud-Ouest (RESO), Hôpitaux Universitaires de Strasbourg, Strasbourg, France

Background: Musculoskeletal (MSK) diseases are expected to have a growing impact worldwide.

Objective: To analyse the worldwide burden of MSK diseases from 2000 to 2015.

Methods: Disability-adjusted life years (DALYs), which combines the years of life lost (YLLs) and the years lived with disability (YLDs), were extracted for 183 countries from the WHO Global Health Estimates Database. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-215142DOI Listing

Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial.

Clin Nutr 2019 Mar 21. Epub 2019 Mar 21.

Department of Pediatric Surgery, Seoul National University Children's Hospital, Seoul, Republic of Korea.

Background: Vitamin D inadequacy is associated with a wide range of diseases. However, optimal strategies to improve vitamin D status, especially in Asian populations, remain unclear. We tested the hypotheses that (1) relevant sun exposure or oral vitamin D supplementation would significantly increase serum 25-hydroxyvitamin D (25OHD) concentrations compared with placebo, (2) sun exposure and supplementary vitamin D would be similar in serum 25OHD increases, and (3) the two interventions may have different effects on cardio-metabolic markers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193013
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http://dx.doi.org/10.1016/j.clnu.2019.03.021DOI Listing
March 2019
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Using Eye Tracking to Assess Gaze Concentration in Meditation.

Sensors (Basel) 2019 Apr 3;19(7). Epub 2019 Apr 3.

Sacred Light Heart Chan Association, Taipei 10351, Taiwan.

An important component of Heart Chan Meditation is gaze concentration training. Here, we determine whether eye tracking can be used to assess gaze concentration ability. Study participants (n = 306) were requested to focus their gaze on the innermost of three concentric circles for 1 min while their eye movements were recorded. Read More

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http://dx.doi.org/10.3390/s19071612DOI Listing

Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus.

Viruses 2019 Apr 3;11(4). Epub 2019 Apr 3.

The Jenner Institute, Nuffield Department of Medicine, University of Oxford. The Henry Wellcome Building for Molecular Physiology, Roosevelt Drive, Oxford, OX3 7BN, UK.

Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness and long-term polyarthralgia. Acute and chronic symptoms impose a major economic burden to health systems and contribute to poverty in affected countries. Read More

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http://dx.doi.org/10.3390/v11040322DOI Listing
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