806,668 results match your criteria Asia Pacific Journal Of Anthropology[Journal]


Transcriptome analyses of Paris polyphylla var. chinensis, Ypsilandra thibetica, and Polygonatum kingianum characterize their steroidal saponin biosynthesis pathway.

Fitoterapia 2019 Apr 15. Epub 2019 Apr 15.

Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China; Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Population, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China. Electronic address:

Steroidal saponins, one of the most diverse groups of plant-derived natural products, elicit biological and pharmacological activities; however, the genes involved in their biosynthesis and the corresponding biosynthetic pathway in monocotyledon plants remain unclear. This study aimed to identify genes involved in the biosynthesis of steroidal saponins by performing a comparative analysis among transcriptomes of Paris polyphylla var. chinensis (PPC), Ypsilandra thibetica (YT), and Polygonatum kingianum (PK). Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.008DOI Listing

Leishmaniasis in Istanbul; A new epidemiological data about refugee leishmaniasis.

Acta Trop 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Microbiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Leishmania is an intracellular parasite, which is transmitted by the bite of infected female Phlebotominae sand flies. Turkey is a crossroad between Europe and Asia that makes it important in terms of epidemiology. In the present study, we aimed to evaluate Leishmania infection among non-autochthonous patients admitted to Health Sciences University, Dr. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X193037
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http://dx.doi.org/10.1016/j.actatropica.2019.04.008DOI Listing
April 2019
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Appearance of Polypoidal Lesions in Patients With Polypoidal Choroidal Vasculopathy Using Swept-Source Optical Coherence Tomographic Angiography.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Importance: Polypoidal choroidal vasculopathy (PCV) is a major cause of visual loss worldwide, particularly in Asia, and the appropriate understanding of the structures in PCV previously described as polypoidal lesions is important for understanding their pathogenesis, diagnosis, and prognosis.

Objective: To report the morphologic characteristics of polypoidal lesions and their association with branching vascular networks (BVNs) in eyes with PCV using swept-source optical coherence tomographic angiography (SS-OCTA).

Design, Setting, And Participants: This cross-sectional observational study included 20 participants recruited from Shanghai General Hospital with a diagnosis of PCV based on the presence of focal hyperfluorescent spots on indocyanine green angiography (ICGA). Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0449DOI Listing

The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis.

PLoS Pathog 2019 Apr 18;15(4):e1007640. Epub 2019 Apr 18.

Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.

Zika virus (ZIKV) has been known for decades to circulate in Africa and Asia. However, major complications of a ZIKV infection have recently become apparent for reasons that are still not fully elucidated. One of the hypotheses for the seemingly increased pathogenicity of ZIKV is that cross-reactive dengue antibodies can enhance a ZIKV infection through the principle of antibody-dependent enhancement (ADE). Read More

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http://dx.plos.org/10.1371/journal.ppat.1007640
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http://dx.doi.org/10.1371/journal.ppat.1007640DOI Listing
April 2019
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Evaluating the Quality and Readability of Online Resources for Labiaplasty.

Female Pelvic Med Reconstr Surg 2019 Apr 12. Epub 2019 Apr 12.

From the Division of Female Pelvic Medicine and Reconstructive Surgery, Ohio State University Wexner Medical Center, Columbus, OH.

Objectives: The aim of this study was to evaluate the quality, readability, and accuracy of Web-based information regarding labiaplasty and to characterize the types of Web sites providing this information.

Methods: Investigators used 3 major search engines to query the internet using the search terms labiaplasty, labia reduction, and vaginal rejuvenation. Two validated tools were used to evaluate Web sites: the JAMA benchmark tool and the DISCERN instrument. Read More

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http://dx.doi.org/10.1097/SPV.0000000000000725DOI Listing

Elevated Blood Lead Levels Among Resettled Refugee Children in Ohio, 2009-2016.

Am J Public Health 2019 Apr 18:e1-e9. Epub 2019 Apr 18.

The authors are with the College of Public Health, Kent State University, Kent, OH.

To assess the prevalence of and the demographic factors for elevated blood lead level (EBLL; ≥ 5 µg/dL) at resettlement among newly admitted refugee children. This cross-sectional study used data from the postresettlement refugee medical screening of 5661 children resettled in Ohio from 2009 to 2016. We computed prevalence of EBLL and adjusted prevalence ratio with modified Poisson regression modeling. Read More

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http://dx.doi.org/10.2105/AJPH.2019.305022DOI Listing

Strengthening of vector control in South-East Asia: Outcomes from a WHO regional workshop.

J Vector Borne Dis 2018 Oct-Dec;55(4):247-257

Department of Communicable Diseases, World Health Organization, South-East Asia Regional Office, New Delhi, India.

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http://dx.doi.org/10.4103/0972-9062.256559DOI Listing
April 2019
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Artificial Intelligence and Optical Coherence Tomography Imaging.

Asia Pac J Ophthalmol (Phila) 2019 Apr 18. Epub 2019 Apr 18.

Harkness Eye Institute, Columbia University, New York, United States.

This review article aimed to highlight the application and use of artificial intelligence (AI) in optical coherence tomography (OCT) imaging in ophthalmology. Artificial intelligence programs seek to simulate intelligent human behavior in computers. With an abundance of patient data, especially with the advent and growing use of imaging modalities such as OCT, AI programs provide us with the unique opportunity to analyze this plethora of information and assist in making clinical decisions in the field of ophthalmology. Read More

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http://www.apjo.org/Apjo/pdf/id/654.html
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http://dx.doi.org/10.22608/APO.201904DOI Listing
April 2019
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Risk factors for neutropenia and febrile neutropenia following prophylactic pegfilgrastim.

Asia Pac J Clin Oncol 2019 Apr 17. Epub 2019 Apr 17.

College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.

Aim: Neutropenia is a common side effect of myelosuppressive chemotherapy. Administration of granulocyte colony-stimulating factor is being used for neutropenia prophylaxis, but there are patients who develop neutropenia or febrile neutropenia despite prophylaxis. We attempted to identify potential risk factors for chemotherapy-induced neutropenia in patients with pegfilgrastim prophylaxis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajco.13152
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http://dx.doi.org/10.1111/ajco.13152DOI Listing
April 2019
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Intraoperative colonoscopy in laparoscopic colorectal surgery: A review of recent publications.

Asian J Endosc Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, The University Hong Kong-Shenzhen Hospital, Shenzhen, China.

Introduction: Laparoscopic colorectal resection is becoming the gold standard for treating colorectal cancers because it offers superior short-term and comparable long-time outcomes compared to open surgery. Intraoperative colonoscopy (IOC) is increasingly performed for tumor localization and mucosal assessment. The aim of this report was to review the safety and efficacy of IOC in laparoscopic colorectal surgery. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ases.12704
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http://dx.doi.org/10.1111/ases.12704DOI Listing
April 2019
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Mainstreaming human and large carnivore coexistence through institutional collaboration.

Conserv Biol 2019 Apr 18. Epub 2019 Apr 18.

School of Life and Environmental Sciences, Centre for Integrative Ecology, Deakin University, Burwood, Victoria, Australia.

Achieving human-large carnivore coexistence in Human Dominated Landscapes (HDL) is a key challenge for societies globally. This challenge cannot be adequately met with the current sectoral approaches of HDL governance and an academic sector largely dominated by disciplinary silos. In this essay, we urge academia (universities and other research institutions and organisations) to take a more active role in embracing societal challenges around large carnivore conservation in HDL. Read More

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http://dx.doi.org/10.1111/cobi.13334DOI Listing

Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression.

Cancer Cell Int 2019 5;19:87. Epub 2019 Apr 5.

16Department of Pharmacy, China Medical University, Taichung, 404 Taiwan.

Background: To determine the association between circadian pathway genetic variants and the risk of prostate cancer progression.

Methods: We systematically evaluated 79 germline variants in nine circadian pathway genes in a cohort of 458 patients with localized prostate cancer as the discovery phase. We then replicated the significant findings in another cohort of 324 men with more advanced disease. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0811-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451277PMC
April 2019
1 Read

Impact of conservation tillage in rice-based cropping systems on soil aggregation, carbon pools and nutrients.

Geoderma 2019 Apr;340:104-114

International Maize and Wheat Improvement Center (CIMMYT), South Asia Regional Office, Kathmandu, Nepal.

Tillage intensive cropping practices have deteriorated soil physical quality and decreased soil organic carbon (SOC) levels in rice-growing areas of South Asia. Consequently, crop productivity has declined over the years demonstrating the need for sustainable alternatives. Given that, a field experiment was conducted for six years to assess the impact of four tillage based crop establishment treatments [puddled transplant rice followed by conventional tillage in wheat/maize (CTTPR-CT), non-puddled transplant rice followed by zero-tillage in wheat/maize (NPTPR-ZT), zero-till transplant rice followed by zero-tillage in wheat/maize (ZTTPR-ZT), zero-tillage direct seeded rice followed by zero-tillage in wheat/maize (ZTDSR-ZT)], two residue management treatments [residue removal, residue retention (~33%)], and two cropping systems [rice-wheat, rice-maize] on soil aggregation, carbon pools, nutrient availability, and crop productivity. Read More

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http://dx.doi.org/10.1016/j.geoderma.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358044PMC

Urinary sodium-to-potassium ratio and intake of sodium and potassium among men and women from multiethnic general populations: the INTERSALT Study.

Hypertens Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

The Na/K ratio may be more strongly related to blood pressure and cardiovascular disease than sodium or potassium. The casual urine Na/K ratio can provide prompt on-site feedback, and with repeated measurements, may provide useful individual estimates of the 24-h ratio. The World Health Organization has published guidelines for sodium and potassium intake, but no generally accepted guideline prevails for the Na/K ratio. Read More

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http://www.nature.com/articles/s41440-019-0263-1
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http://dx.doi.org/10.1038/s41440-019-0263-1DOI Listing
April 2019
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Enigmatic incongruence between mtDNA and nDNA revealed by multi-locus phylogenomic analyses in freshwater snails.

Sci Rep 2019 Apr 17;9(1):6223. Epub 2019 Apr 17.

Graduate school of Life Sciences, Tohoku University, Miyagi, Japan.

Phylogenetic incongruence has frequently been encountered among different molecular markers. Recent progress in molecular phylogenomics has provided detailed and important information for evolutionary biology and taxonomy. Here we focused on the freshwater viviparid snails (Cipangopaludina chinensis chinensis and C. Read More

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http://www.nature.com/articles/s41598-019-42682-0
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http://dx.doi.org/10.1038/s41598-019-42682-0DOI Listing
April 2019
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Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi, United States

Subtype H10 influenza A viruses (IAVs) have been recovered from domestic poultry and various aquatic bird species, and sporadic transmission of these IAVs from avian species to mammals (i.e., human, seal, and mink) are well documented. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00282-19
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http://dx.doi.org/10.1128/JVI.00282-19DOI Listing
April 2019
2 Reads

Hospital-derived antibody profiles of malaria patients in Southwest India.

Malar J 2019 Apr 17;18(1):138. Epub 2019 Apr 17.

Department of Chemistry and Department of Global Health, University of Washington, Seattle, WA, 98195, USA.

Background: Naturally acquired immunity to malaria across the globe varies in intensity and protective powers. Many of the studies on immunity are from hyperendemic regions of Africa. In Asia, particularly in India, there are unique opportunities for exploring and understanding malaria immunity relative to host age, co-occurrence of Plasmodium falciparum and Plasmodium vivax infections, varying travel history, and varying disease severity. Read More

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http://dx.doi.org/10.1186/s12936-019-2771-5DOI Listing

Antimicrobial-resistant Gram-negative colonisation in infants from a NICU in Thailand.

J Hosp Infect 2019 Apr 14. Epub 2019 Apr 14.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalised neonates in South and South-East Asia. We aimed to determine the dynamics of colonisation with antimicrobial-resistant Gram-negative bacteria amongst infants in a neonatal intensive care unit (NICU) in Thailand. From a total of 97 enrolled infants, 52% of neonates were colonised by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonised by a carbapenem-resistant organism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01956701193015
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http://dx.doi.org/10.1016/j.jhin.2019.04.004DOI Listing
April 2019
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Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption.

N Engl J Med 2019 04;380(16):1535-1545

From United Biomedical, Hauppauge, NY (C.-Y.W., B.-S.K., C.L.F., F.W.-S.); United Biomedical Asia (C.-Y.W., S.L.) and United BioPharma (C.-Y.W., B.-S.K., H.-W.S., C.-Y.L., F.-C.T., A.L., F.-H.Y., C.-H.L., W.T., M.-J.L.), Hsinchu, Taipei Veterans General Hospital, Taipei (W.-W.W., H.-Y.L.), and Kaohsiung Veterans General Hospital (H.-C.T.) and Kaohsiung Medical University Hospital (Y.-H.C.), Kaohsiung - all in Taiwan; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (J.B., K.E.C., T.-W.C.); and the California Department of Public Health, Richmond (C.V.H.).

Background: Administration of a single broadly neutralizing human immunodeficiency virus (HIV)-specific antibody to HIV-infected persons leads to the development of antibody-resistant virus in the absence of antiretroviral therapy (ART). It is possible that monotherapy with UB-421, an antibody that blocks the virus-binding site on human CD4+ T cells, could induce sustained virologic suppression without induction of resistance in HIV-infected persons after analytic treatment interruption.

Methods: We conducted a nonrandomized, open-label, phase 2 clinical study evaluating the safety, pharmacokinetics, and antiviral activity of UB-421 monotherapy in HIV-infected persons undergoing analytic treatment interruption. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1802264
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http://dx.doi.org/10.1056/NEJMoa1802264DOI Listing
April 2019
4 Reads

Geographic expansion of artemisinin resistance.

J Travel Med 2019 Apr 17. Epub 2019 Apr 17.

Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: Artemisinin-based combination therapy (ACT) is the global standard of care for uncomplicated falciparum malaria. First reports of ACT resistance came from western Cambodia and the Thailand-Cambodia border in 2002-2004. The subsequent emergence and expansion of P. Read More

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http://dx.doi.org/10.1093/jtm/taz030DOI Listing

Malaria Standby Emergency Treatment (SBET) for Travelers Visiting Malaria Endemic Areas: a Systematic Review and Meta-Analysis.

J Travel Med 2019 Apr 17. Epub 2019 Apr 17.

Department of research, innovation and training, Unisanté, Center for Primary Care and Public Health, University of Lausanne, Switzerland.

Malaria prevention methods for travelers to low or moderate malaria risk areas varies and remains controversial. Standby Emergency Treatment (SBET) for malaria is one possible strategy increasingly recommended since 1988 with little evidence on its effectiveness or how it is truly being used. A systematic review and meta-analysis were performed based on a structured search in Embase, Medline, PubMed, Cochrane, and Web of Science on September 7, 2018. Read More

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http://dx.doi.org/10.1093/jtm/taz027DOI Listing

Evolutionary history of burrowing asps (Lamprophiidae: Atractaspidinae) with emphasis on fang evolution and prey selection.

PLoS One 2019 17;14(4):e0214889. Epub 2019 Apr 17.

Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America.

Atractaspidines are poorly studied, fossorial snakes that are found throughout Africa and western Asia, including the Middle East. We employed concatenated gene-tree analyses and divergence dating approaches to investigate evolutionary relationships and biogeographic patterns of atractaspidines with a multi-locus data set consisting of three mitochondrial (16S, cyt b, and ND4) and two nuclear genes (c-mos and RAG1). We sampled 91 individuals from both atractaspidine genera (Atractaspis and Homoroselaps). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214889PLOS
April 2019
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A new hadrosauroid (Dinosauria: Ornithopoda) from the Late Cretaceous Baynshire Formation of the Gobi Desert (Mongolia).

PLoS One 2019 17;14(4):e0208480. Epub 2019 Apr 17.

Department of Geosciences, Faculty of Science, Osaka City University, Osaka Prefecture, Osaka, Japan.

A new genus and species of non-hadrosaurid hadrosauroid, Gobihadros mongoliensis, is described from a virtually complete and undeformed skull and postcranial skeleton, as well as extensive referred material, collected from the Baynshire Formation (Cenomanian-Santonian) of the central and eastern Gobi Desert, Mongolia. Gobihadros mongoliensis is the first non-hadrosaurid hadrosauroid from the Late Cretaceous of central Asia known from a complete, articulated skull and skeleton. The material reveals the skeletal anatomy of a proximate sister taxon to Hadrosauridae in remarkable detail. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208480PLOS

Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission.

PLoS Negl Trop Dis 2019 Apr 17;13(4):e0007343. Epub 2019 Apr 17.

Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities; St. Paul, MN, United States of America.

Congenital Zika virus (ZIKV) infection was first linked to birth defects during the American outbreak in 2015/2016. It has been proposed that mutations unique to the Asian/American-genotype explain, at least in part, the ability of Asian/American ZIKV to cause congenital Zika syndrome (CZS). Recent studies identified mutations in ZIKV infecting humans that arose coincident with the outbreak in French Polynesia and were stably maintained during subsequent spread to the Americas. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007343DOI Listing

Factors influencing engagement in premarital sex among Vietnamese young adults: a qualitative study.

Int J Adolesc Med Health 2019 Apr 17. Epub 2019 Apr 17.

Bournemouth University, Faculty of Health and Social Sciences, Bournemouth House, Bournemouth, BH21 3UJ, UK.

Background With the rising trend of sexual engagement among Vietnamese young adults in recent years, concerns were raised over the issue of premarital sex and its potential health consequences. In order to prevent such consequences and further promote health, an in-depth understanding of factors influencing young people to have premarital sex would be valuable. Objective To generate a grounded theory explaining factors influencing engagement in premarital sex among Vietnamese young adults. Read More

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http://dx.doi.org/10.1515/ijamh-2018-0201DOI Listing

Patient-Reported and Functional Outcomes After Revision Amputation and Replantation of Digit Amputations: The FRANCHISE Multicenter International Retrospective Cohort Study.

JAMA Surg 2019 Apr 17. Epub 2019 Apr 17.

Research and Scientific Affairs, The Plastic Surgery Foundation, Arlington Heights, Illinois.

Importance: Optimal treatment for traumatic digit amputation is unknown.

Objective: To compare long-term patient-reported and functional outcomes between patients treated with revision amputation or replantation for digit amputations.

Design, Setting, And Participants: Retrospective cohort study at 19 centers in the United States and Asia. Read More

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http://dx.doi.org/10.1001/jamasurg.2019.0418DOI Listing

Historical Black Carbon Reconstruction from the Lake Sediments of the Himalayan - Tibetan Plateau.

Environ Sci Technol 2019 Apr 17. Epub 2019 Apr 17.

Black Carbon (BC) is one of the major drivers of climate change and its measurement in different environment is crucial for better understanding of long-term trend in Himalayan-Tibetan Plateau (HTP) as climate warming has intensified in the region. We present measurement of BC concentration from six lake sediments in HTP to reconstruct historical BC deposition since the preindustrial era. Our results show an increasing trend of BC, concurrent with increased anthropogenic emission pattern after the commencement of an industrialization era during the 1950s. Read More

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http://dx.doi.org/10.1021/acs.est.8b07025DOI Listing

Elevated Human Crimean-Congo Hemorrhagic Fever Virus Seroprevalence in Khashm el Girba, Eastern Sudan.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Institute for Virology, University Clinics and Medical Faculty, University of Leipzig, Leipzig, Germany.

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that can evolve into deadly hemorrhagic fever and that is endemic in many parts of Europe, Middle East, Central Asia, and Africa. Because of several reports about CCHF outbreaks in the south of Sudan during the last years, we examined in this study if unrecognized CCHF-V infections also occurred in the eastern and central parts of the country. The study examined the seroprevalence of CCHF virus infection in 464 sera from three regions of Sudan without previous reports of CCHF infection. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0977DOI Listing

The Investment Case for Malaria Elimination in Thailand: A Cost-Benefit Analysis.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

RTI International, Washington, District of Columbia.

After a dramatic decline in the annual malaria incidence in Thailand since 2000, the Thai government developed a National Malaria Elimination Strategy (NMES) to end local malaria transmission by 2024. This study examines the expected costs and benefits of funding the NMES (elimination scenario) versus not funding malaria elimination programming (resurgence scenario) from 2017 to 2036. Two case projection approaches were used to measure the number of malaria cases over the study period, combined with a set of Thailand-specific economic assumptions, to evaluate the cost of a malaria case and to quantify the cost-benefit ratio. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0897DOI Listing

A Prospective Study on the Impact and Out-of-Pocket Costs of Dengue Illness in International Travelers.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Although the costs of dengue illness to patients and households have been extensively studied in endemic populations, international travelers have not been the focus of costing studies. As globalization and human travel activities intensify, travelers are increasingly at risk for emerging and reemerging infectious diseases, such as dengue. This exploratory study aims to investigate the impact and out-of-pocket costs of dengue illness among travelers. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0780DOI Listing

A Simple Solution That Saves Lives: Overcoming Diarrheal Disease in the Age of Universal Health Coverage.

Asia Pac J Public Health 2018 Oct;30(7):604-606

2 Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1177/1010539518809444DOI Listing
October 2018

Paraquat Exposure Through Breast-feeding.

Asia Pac J Public Health 2018 Oct;30(7):673-674

3 Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 10400.

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http://dx.doi.org/10.1177/1010539518808847DOI Listing
October 2018

Commentary: Hazards of Agricultural Chemicals and the Benefits of an Occupational Health Education Program for Thai Farmers.

Asia Pac J Public Health 2018 Oct;30(7):607-609

2 Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1177/1010539518808956DOI Listing
October 2018

Co-infection of peste des petits ruminants and goatpox in a mixed flock of sheep and goats in Kanam, North Central Nigeria.

Vet Med Sci 2019 Apr 17. Epub 2019 Apr 17.

Central Diagnostic Laboratory, National Veterinary Research Institute, Vom, Nigeria.

Peste-des-petits-ruminants (PPR) and Goat pox (GTP) are two devastating and economically important transboundary animal diseases of small ruminants in Africa and Asia that have been difficult to control. This study however, investigated an outbreak of PPR and GTP in a mixed flock of indigenous sheep and goats in Kanam, North Central Nigeria. A total of nine sera and seven tissues (lungs, spleen, scab and skin) samples were collected and analysed in the laboratory using competitive enzyme linked immunosorbent assay (cELISA) for PPR antibodies and polymerase chain reaction (PCR) for detection of PPR virus (PPRV) and GTP virus (GTPV). Read More

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http://dx.doi.org/10.1002/vms3.170DOI Listing

Effect of genetic variants in cell adhesion pathways on the biochemical recurrence in prostate cancer patients with radical prostatectomy.

Cancer Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacy, China Medical University, Taichung, Taiwan.

The aberrant expression of cell adhesion molecules is a hallmark of epithelial-to-mesenchymal transition, resulting in the transformation of cancer cells to a more aggressive phenotype. This study investigated the association between genetic variants in cell adhesion pathways and the prognosis of patients with prostate cancer following radical prostatectomy (RP). A total of 18 haplotype-tagging single-nucleotide polymorphisms (SNPs) in eight cancer-related adhesion molecules were genotyped in 458 prostate cancer patients, followed by the replication of the top SNPs in an additional set of 185 patients. Read More

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http://dx.doi.org/10.1002/cam4.2163DOI Listing

Stress and other factors associated with colorectal cancer outpatients with temporary colostomies.

Eur J Cancer Care (Engl) 2019 Apr 16:e13054. Epub 2019 Apr 16.

National Cheng Kung University Hospital, Tainan City, Taiwan.

This study investigated stress and other factors associated with colorectal cancer (CRC) outpatients with temporary colostomies in Taiwan. Temporary colostomies have been incorporated as a defecation alternative to maintain physical function and are accompanied by chemotherapy/radiotherapy in CRC patients. A cross-sectional study was conducted, and a convenience sampling approach was adopted to recruit 110 discharged CRC patients with temporary colostomies from a medical centre in southern Taiwan. Read More

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http://dx.doi.org/10.1111/ecc.13054DOI Listing

Does drug-induced sleep endoscopy affect surgical outcome? A multicenter study of 326 obstructive sleep apnea patients.

Laryngoscope 2019 Apr 17. Epub 2019 Apr 17.

Otolaryngology Department, Western University, London, Ontario, Canada.

Objectives/hypothesis: Our objective was to determine whether drug-induced sleep apnea (DISE) affects the successfulness of the surgical outcome.

Study Design: Prospective, seven-country, nonrandomized trial.

Methods: There were 326 consecutive obstructive sleep apnea (OSA) patients who had nose, palate, and/or tongue surgery included in the study. Read More

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http://dx.doi.org/10.1002/lary.27987DOI Listing

Vaccines for emerging pathogens: from research to the clinic.

Authors:
E D Williamson

Clin Exp Immunol 2019 May;196(2):155-156

Defence Science and Technology Laboratory, Porton Down, Salisbury, UK.

In this two-part series of reviews, we have invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens. This topic has been brought into sharp focus in recent years following significant outbreaks of viral diseases such as those causing severe acute respiratory syndrome and Middle East respiratory syndrome, as well as devastating outbreaks of diseases caused by the Ebola, Marburg, Zika and Lassa fever viruses, to name only a few examples. Additionally, bacterial infections leading to bubonic and pneumonic plague, most notably in Madagascar in 2018, as well as malaria in many tropical countries, melioidosis in south east Asia and tularaemia in northern Europe and North America, have incurred significant morbidity and mortality. Read More

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http://doi.wiley.com/10.1111/cei.13303
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http://dx.doi.org/10.1111/cei.13303DOI Listing
May 2019
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Molecular phylogenetic species delimitation in the aquatic genus Ottelia (Hydrocharitaceae) reveals cryptic diversity within a widespread species.

J Plant Res 2019 Apr 16. Epub 2019 Apr 16.

Kadoorie Farm and Botanic Garden, Lam Kam Road, Tai Po, Hong Kong, People's Republic of China.

Ottelia, a pantropical genus of aquatic plants belonging to the family Hydrocharitaceae, includes several narrowly distributed taxa in Asia. Although the Asian species have received comparatively more research attention than congeners in other areas, various key taxonomic questions remain unaddressed, especially with regards to apparent cryptic diversity within O. alismoides, a widespread species complex native to Asia, northern Australia and tropical Africa. Read More

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http://dx.doi.org/10.1007/s10265-019-01109-7DOI Listing

Distribution and Ecological Drivers of Spotted Fever Group Rickettsia in Asia.

Ecohealth 2019 Apr 15. Epub 2019 Apr 15.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithee Road, Bangkok, 10400, Thailand.

Spotted fever group and related rickettsia (SFGR) are a neglected group of pathogens that belong to the genus Rickettsia. SFGR are zoonotic and are transmitted by arthropod vectors, primarily ticks, fleas and mites to accidental hosts. These emerging and re-emerging infections are widely distributed throughout the world. Read More

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http://link.springer.com/10.1007/s10393-019-01409-3
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http://dx.doi.org/10.1007/s10393-019-01409-3DOI Listing
April 2019
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A unilateral less invasive posterolateral approach for disc debridement and titanium cage insertion supplemented by contralateral transfascial screw fixation for high-morbidity patients suffering from septic thoracolumbosacral spondylodiscitis.

Eur J Orthop Surg Traumatol 2019 Apr 16. Epub 2019 Apr 16.

AMR Advanced Medical Research GmbH, Hofenstrasse 89b, 8708, Männedorf, Switzerland.

Purpose: This case series reports on the efficacy and safety of a less invasive posterolateral approach for septic thoracolumbosacral spondylodiscitis in high-morbidity patients.

Methods: Twenty consecutive severe sick (ASA > III) patients (14 men and 6 women), with an average age of 64 ± 14 years, suffering from septic subacute and chronic thoracolumbosacral spondylodiscitis were selected to undergo a one-stage less invasive unilateral posterolateral disc space debridement, supplemented by an ipsilateral titanium cage implantation and pedicle screw fixation plus a contralateral transfascial pedicle screw fixation.

Results: Two high-risk patients with severe comorbidities (ASA stage IV and V, respectively) died on days 1 and 8 postoperatively because of non-surgical complications such as massive lung embolism and acute myocardial infract, respectively. Read More

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http://link.springer.com/10.1007/s00590-019-02434-2
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http://dx.doi.org/10.1007/s00590-019-02434-2DOI Listing
April 2019
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Dietary Patterns and Determinants of Changing Diets in Bangladesh from 1985 to 2010.

Curr Dev Nutr 2019 Apr 21;3(4):nzy091. Epub 2018 Nov 21.

Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany.

Background: The government of Bangladesh has implemented multiple policies since 1971 to provide the population with more diverse and nutritious diets.

Objective: The aim of this study was to examine the drivers of dietary change over time and the roles agriculture and economic development have played.

Methods: We used principal component analysis to derive dietary patterns from 7 cross-sectional rounds of the Bangladesh Household [Income and] Expenditure Survey. Read More

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http://dx.doi.org/10.1093/cdn/nzy091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459985PMC

Safety and Efficacy of Reduced Prolonged-release Tacrolimus Exposure in De Novo Kidney Transplantation: A Randomized, Open-label, Pilot Study in Asia-OPTIMIZE Study.

Transplant Direct 2019 Apr 25;5(4):e340. Epub 2019 Mar 25.

Division of Kidney and Pancreas Transplant, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: A multicenter, randomized, open-label, parallel group, pilot, 52-week study in Asian countries that assessed the renal function, efficacy, and safety of reduced-exposure versus standard-exposure prolonged-release tacrolimus (PR-T) in adult kidney transplant recipients (KTRs).

Methods: Posttransplantation, KTRs received PR-T from weeks 0 to 4 (initial dose, 0.2-0. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445651PMC

Recurrent Cough and Expectoration for 10 Years: A Case Report.

Glob Pediatr Health 2019 4;6:2333794X19833725. Epub 2019 Apr 4.

The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China.

. Most cases of cystic fibrosis occur in Europe, with only a few occurring in Asia. Pulmonary cystic fibrosis is not a rare disease, but in children it is a potentially life-threatening condition. Read More

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http://journals.sagepub.com/doi/10.1177/2333794X19833725
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http://dx.doi.org/10.1177/2333794X19833725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449808PMC
April 2019
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Salivary is a gender-difference biomarker of oral squamous cell carcinoma.

PeerJ 2019 9;7:e6732. Epub 2019 Apr 9.

Department of Healthcare Administration, Asia University, Taichung, Taiwan.

Background: The X-linked tumor suppressor gene is reported to be involved in oral cancer. The detection of biomarkers in salivary RNA is a non-invasive strategy for diagnosing many diseases. The aim of the present study was to investigate the potential of salivary as a biomarker of oral cancer. Read More

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https://peerj.com/articles/6732
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http://dx.doi.org/10.7717/peerj.6732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461027PMC
April 2019
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Evolutionary and Genomic Insights into Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health Importance.

MBio 2019 Apr 16;10(2). Epub 2019 Apr 16.

Medical, Molecular and Forensic Sciences, Murdoch University, Western Australia, Australia

() sequence type 11 (ST11) is well established in production animal populations worldwide and contributes considerably to the global burden of infection (CDI) in humans. Increasing evidence of shared ancestry and genetic overlap of PCR ribotype 078 (RT078), the most common ST11 sublineage, between human and animal populations suggests that CDI may be a zoonosis. We performed whole-genome sequencing (WGS) on a collection of 207 ST11 and closely related ST258 isolates of human and veterinary/environmental origin, comprising 16 RTs collected from Australia, Asia, Europe, and North America. Read More

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http://dx.doi.org/10.1128/mBio.00446-19DOI Listing

Designing a comprehensive Non-Communicable Diseases (NCD) programme for hypertension and diabetes at primary health care level: evidence and experience from urban Karnataka, South India.

BMC Public Health 2019 Apr 16;19(1):409. Epub 2019 Apr 16.

Karnataka Health Promotion Trust, Bangalore, India.

Background: India accounts for more than two-third of mortality due to non-communicable diseases (NCDs) in south-east Asia. The burden is high in Karnataka, one of the largest states in southern India. There is a need for integration of disease prevention, health promotion, treatment and care within the national program at primary level. Read More

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http://dx.doi.org/10.1186/s12889-019-6735-zDOI Listing

Modelling global river export of microplastics to the marine environment: Sources and future trends.

Sci Total Environ 2019 Apr 8;673:392-401. Epub 2019 Apr 8.

Department of Science, Faculty of Management, Science & Technology, Open University, Heerlen, the Netherlands; Water Systems and Global Change Group, Wageningen University & Research, Wageningen, the Netherlands.

Microplastics, transported by rivers to oceans, are triggering environmental concern. This study aims to better understand river export of microplastics from land to sea. We developed the Global Riverine Export of Microplastics into Seas (GREMiS) model, a global, spatially explicit model for analysing the annual microplastics export to coastal seas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193159
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.078DOI Listing
April 2019
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The in vitro and in vivo depigmenting activity of Coenzyme Q10 through the down-regulation of α-MSH signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated skin keratinocytes.

Biochem Pharmacol 2019 Apr 13. Epub 2019 Apr 13.

Institute of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan. Electronic address:

Coenzyme CoQ10 (CoQ10), a ubiquinone compound, has been reported to inhibit tyrosinase activity and melanin production in melanoma B16F10 cells. However, the molecular mechanism underlying this inhibitory effect is poorly understood. In this paper we aimed to investigate the molecular mechanisms involved in the anti-melanogenic activity of CoQ10 (1-2 μM) in UVA (5 J/cm)-irradiated keratinocyte HaCaT cells and α-MSH stimulated B16-F10 cells. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.04.015DOI Listing

Correlation between the protein expression levels of A-kinase anchor protein95, p-retinoblastoma (Ser780), cyclin D2/3, and cyclin E2 in esophageal cancer tissues.

Asia Pac J Clin Oncol 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen Fujian, China.

Aim: This study aimed to investigate the correlation between the expression of A-kinase anchor protein95 (AKAP95), p-retinoblastoma (phosphorylated Rb, p-Rb), cyclin D2, cyclin D3 and cyclin E2 in esophageal cancer tissues and clinicopathological indexes.

Method: The protein expression levels of AKAP95, p-Rb, cyclin D2/3 and cyclin E2 in 40 esophageal cancer tissues were detected using immunohistochemistry, and the correlation between them was analyzed.

Result: The percentage of p-Rb (Ser780)-, cyclin D2-, cyclin D3- and cyclin E2-positive samples was 62. Read More

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http://dx.doi.org/10.1111/ajco.13146DOI Listing
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