874,840 results match your criteria Asia Pacific Business Review[Journal]


Superior haplotypes for haplotype-based breeding for drought tolerance in pigeonpea (Cajanus cajan L.).

Plant Biotechnol J 2020 May 26. Epub 2020 May 26.

Center of Excellence in Genomics & Systems Biology (CEGSB), International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, 502324, Telangana State, India.

Haplotype-based breeding, a recent promising breeding approach to develop tailored made crop varieties deals with identification of superior haplotypes and their deployment in breeding programs. In this context, whole genome re-sequencing data of 292 genotypes from pigeonpea reference set was mined to identify the superior haplotypes for 10 drought-responsive candidate genes. A total of 83, 132 and 60 haplotypes were identified in breeding lines, landraces and wild species, respectively. Read More

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http://dx.doi.org/10.1111/pbi.13422DOI Listing

Methylation in Nasopharyngeal Swabs: A Potential Minimally Invasive Biomarker for the Early Detection of Nasopharyngeal Carcinoma.

Dis Markers 2020 5;2020:7253531. Epub 2020 May 5.

Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.

Nasopharyngeal carcinoma (NPC) is highly prevalent in Southeast Asia, and an unfavorable outcome is usually attributed to advanced stage NPC. Current methods for the early diagnosis of NPC have limitations in clinical practice. The aim of this study was to investigate the diagnostic ability of methylation for NPC. Read More

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http://dx.doi.org/10.1155/2020/7253531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232724PMC

Diagnosis and Management of Graves' Disease in Thailand: A Survey of Current Practice.

J Thyroid Res 2020 11;2020:8175712. Epub 2020 May 11.

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Background: The data on clinical practice patterns in the evaluation and management of Graves' disease (GD) are limited in Asia. The aims of this survey were to report the current practices in the management of GD in Thailand and to examine any international differences in the management of GD.

Methods: Members of the Endocrine Society of Thailand who were board certified in endocrinology ( = 392) were invited to participate in an electronic survey on the management of GD using the same index case and questionnaire as in previous North American and European surveys. Read More

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http://dx.doi.org/10.1155/2020/8175712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238361PMC

Prevalence of per- and polyfluoroalkyl substances (PFASs) in drinking and source water from two Asian countries.

Chemosphere 2020 May 19;256:127115. Epub 2020 May 19.

Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, United States. Electronic address:

The present study focuses on the determination of the occurrence and levels of per- and polyfluoroalkyl substances (PFASs) in the drinking and source water from the Philippines and Thailand. A total of 46 samples (18 commercial bottled waters, 5 drinking water from vending machine (re-fill stations) and 23 source water) were analyzed using liquid chromatography with tandem high-resolution mass spectrometry. Using the targeted method, 12 different PFASs were detected in the drinking water samples with total quantifiable PFASs (∑PFASs) levels ranging from 7. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127115DOI Listing

Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil.

Acta Trop 2020 May 23:105537. Epub 2020 May 23.

Universidade Federal do Pará, Instituto de Ciências Biológicas, CEP: 66075-110, Belém, Pará, Brazil.

Plasmodium vivax remains an important cause of malaria in South America and Asia, and analyses of the antibody immune response are being used to identify biomarker of parasite exposure. The IgG antibody naturally acquired predominantly occurs against targets on blood-stage parasites, including C-terminal of the merozoite surface protein 1 (MSP1-19). Epidemiological and immunological evidence has been showed that antibodies to malaria parasite antigens are lost in the absence of ongoing exposure. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105537DOI Listing

The origins of the fight against rabies: a journey between the history of neuroscience and university museum collections.

Authors:
M C Garbarino

Funct Neurol 2019 Jul/Sep;34(3):196-204

Although rabies, or hydrophobia, is one of the so-called forgotten tropical diseases, it still kills thousands of people each year, especially children living in rural areas of Asia and Africa. This terrible disease was once a much-feared threat throughout Europe, whose terrifying symptoms were described in a vast body of literature that was based on both science and popular beliefs. One notable individual whose name is linked to the fight against this disease is Adelchi Negri, a brilliant but unfortunate pupil of Camillo Golgi. Read More

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An outbreak of Japanese encephalitis caused by genotype Ib Japanese encephalitis virus in China, 2018: A laboratory and field investigation.

PLoS Negl Trop Dis 2020 May 26;14(5):e0008312. Epub 2020 May 26.

Department of Arbovirus, NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Although Japanese encephalitis virus genotype Ib (JEV GIb) has replaced JEV GIII as the dominant genotype in endemic areas of Asia, no JEV GIb has been isolated from JE cases and natural mosquitoes at the same time in an outbreak of JE. In this study, we conducted virological and molecular biological laboratory tests on JE case samples (serum/cerebrospinal fluid) and locally collected mosquito samples from the 2018 JE outbreak in Ningxia, China. The result of JEV IgM antibody detection showed that 96% (67/70) of the suspected cases were laboratory-confirmed JE cases. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008312DOI Listing

Comparison of tobacco-specific nitrosamine levels in smokeless tobacco products: High levels in products from Bangladesh.

PLoS One 2020 26;15(5):e0233111. Epub 2020 May 26.

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, United States of America.

Bangladesh exhibits the second highest rate of smokeless tobacco (SLT) product usage in the world, and this has been associated with the high upper aerodigestive tract cancer incidence in this country. The goal of the present study was to examine the levels of the highly carcinogenic tobacco-specific nitrosamines (TSNAs) in Bangladeshi SLT products and compare these levels to that observed in SLT brands from southeast Asia and the USA. The levels of TSNAs and nicotine were determined by LC-MS/MS in twenty-eight SLT brands and several tobacco additives from Bangladesh, as well as several SLT brands from India, Pakistan and the USA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233111PLOS

What's in the Neuromuscular Junction Literature?

Authors:
David Lacomis

J Clin Neuromuscul Dis 2020 Jun;21(4):195-204

Departments of Neurology and Pathology (Neuropathology), University of Pittsburgh School of Medicine, Pittsburgh, PA.

Four retrospective studies from the United States, Europe, and Asia address outcomes in juvenile myasthenia gravis. Common features include earlier onset with ocular myasthenia gravis (MG) and generally good outcomes overall. Patients who were seronegative, had equivocal acetylcholine receptor (AChR) antibodies, or had only clustered AChR antibodies had better outcomes. Read More

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http://dx.doi.org/10.1097/CND.0000000000000285DOI Listing

Essential oil composition of three Cryptocarya species from Malaysia.

Z Naturforsch C J Biosci 2020 May 26. Epub 2020 May 26.

School of Environmental and Natural Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia.

Cryptocarya species are mainly distributed in Africa, Asia, Australia and South America, widely used in traditional medicines for the treatment of skin infections and diarrhea. The present investigation reports on the extraction by hydrodistillation and the chemical composition of three Cryptocarya species (Cryptocarya impressa, Cryptocarya infectoria, and Cryptocarya rugulosa) essential oils from Malaysia. The chemical composition of these essential oils was fully characterized by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Read More

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http://dx.doi.org/10.1515/znc-2020-0079DOI Listing

Finding the Best Way to Deliver Online Educational Content in Low-Resource Settings: Qualitative Survey Study.

Authors:
Lucy Kynge

JMIR Med Educ 2020 May 26;6(1):e16946. Epub 2020 May 26.

Interburns, Swansea University, Swansea, United Kingdom.

Background: The reach of internet and mobile phone coverage has grown rapidly in low- and middle-income countries (LMICs). The potential for sharing knowledge with health care workers in low-resource settings to improve working practice is real, but barriers exist that limit access to online information. Burns affect more than 11 million people each year, but health care workers in low-resource settings receive little or no training in treating burn patients. Read More

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http://dx.doi.org/10.2196/16946DOI Listing

A Genome Sequence Resource for the Geographically Widespread Anthracnose Pathogen .

Plant Dis 2020 May 26:PDIS01200034A. Epub 2020 May 26.

State Key Laboratory of Crop Stress Biology in Arid Areas and College of Plant Protection, Northwest A&F University, Yangling, Shaanxi Province 712100, China.

is a worldwide plant pathogen causing serious fruit or leaf anthracnose diseases on a variety of plant hosts such as mango, coffee berry, chili, and other potential hosts, and it is distributed widely in Asia, America, Africa, and Oceania. This is the first genome resource available for The draft genome assembly will allow further analysis of species diversity and evolutionary mechanisms, and may serve as a foundation for genetic analysis that leads to greater understanding of interactions between plants and fungal pathogens. Read More

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http://dx.doi.org/10.1094/PDIS-01-20-0034-ADOI Listing

Optical coherence tomography neurodegenerative findings in patients with bipolar disorder.

Asia Pac Psychiatry 2020 May 26:e12394. Epub 2020 May 26.

Department of Biostatistics, Faculty of Medicine, Hitit University, Çorum, Turkey.

Introduction: Neuroimaging studies of patients with bipolar disorder (BD) have recently revealed neurodegenerative changes in the central nervous system. Optical coherence tomography (OCT) imaging of the retina, as an extension of brain, may be a biomarker in understanding the neurobiology of the disease. To assess OCT as a tool to detect neurodegeneration in BD we compared the retinal changes between patients with BD and healthy individuals. Read More

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http://dx.doi.org/10.1111/appy.12394DOI Listing

Parasympathetic activity as a potential biomarker of negative symptoms in patients with schizophrenia.

Asia Pac Psychiatry 2020 May 26:e12392. Epub 2020 May 26.

Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan.

Introduction: Autonomic dysfunction in patients with schizophrenia has raised concern considering the higher cardiovascular mortality and morbidity rate. This phenomenon has been demonstrated using various measurements and is inferred to be associated with demographics, medical treatment, and psychopathology. However, few have targeted the role of negative symptoms within schizophrenia. Read More

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http://dx.doi.org/10.1111/appy.12392DOI Listing

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth.

Cochrane Database Syst Rev 2020 May 26;5:CD013633. Epub 2020 May 26.

Effective Care Research Unit, University of the Witwatersrand/Fort Hare, East London, South Africa; Centre for Evidence-based Health Care, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa; and, University of Botswana, Gaborone, Botswana.

Background: Preterm birth is a serious and common pregnancy complication. The burden is particularly high in low- and middle-income countries where available care is often inadequate to ensure preterm newborn survival. Administration of antenatal corticosteroids (ACS) is recommended as the standard care for the management of women at risk of imminent preterm birth but its coverage varies globally. Read More

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http://dx.doi.org/10.1002/14651858.CD013633DOI Listing

Peste Des Petits Ruminants Virus and Goatpox Virus Co-Infection in Goats.

Vet Pathol 2020 May 26:300985820926954. Epub 2020 May 26.

Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.

Infection of small ruminants with peste des petits ruminants virus (PPRV) and goatpox virus (GTPV) are endemic and can have devastating economic consequences in Asia and Africa. Co-infection with these viruses have recently been reported in goats and sheep in Nigeria. In this study, we evaluated samples from the lips of a red Sokoto goat, and describe co-infection of keratinocytes with PPRV and GTPV using histopathology and transmission electron microscopy. Read More

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http://dx.doi.org/10.1177/0300985820926954DOI Listing

[Treatment of spine metastases by open decompression, microwave ablation combined with open vertebroplasty and pedicle screw rod system].

Zhongguo Gu Shang 2020 May;33(5):470-6

Department of Orthopaedics, Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou 350000, Fujian, China.

Objective: To evaluate the preliminary clinical effective of open decompression, microwave ablation combined with open vertebroplasty and pedicle screw rod system in the treatment of spine metastases.

Methods: The clinical data of 12 patients with spine metastases were retrospectively analyzed, they were treated with open decompression, microwave ablation combined with open vertebroplasty and pedicle screw rod system between January 2014 and January 2016. Six males and 6 females were included, aged from 30 to 75 years old with an average of 55. Read More

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http://dx.doi.org/10.12200/j.issn.1003-0034.2020.05.016DOI Listing

Cholinergic Receptors and Addiction.

Curr Top Behav Neurosci 2020 May 26. Epub 2020 May 26.

Department of Psychiatry and Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Human behavior can be controlled by physical or psychological dependencies associated with addiction. One of the most insidious addictions in our society is the use of tobacco products which contain nicotine. This addiction can be associated with specific receptors in the brain that respond to the natural neurotransmitter acetylcholine. Read More

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http://dx.doi.org/10.1007/7854_2020_139DOI Listing

Comparison of Surgical Activity and Scientific Publications in Bariatric Surgery: an Epidemiological and Bibliometric Analysis.

Obes Surg 2020 May 25. Epub 2020 May 25.

Digestive and Obesity Surgery Departement, Hôpital Intercommunal de Créteil, Créteil, France.

Introduction: In the last two decades, an impressive increase in the number of surgical interventions was recorded in bariatric surgery. Similarly, several bibliometric studies reported an increasing trend for scientific production. This study aims to compare these two trends. Read More

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http://dx.doi.org/10.1007/s11695-020-04703-0DOI Listing

Modeling the Putative Ancient Distribution of Aedes togoi (Diptera: Culicidae).

J Insect Sci 2020 May;20(3)

Department of Zoology, University of British Columbia, Vancouver, BC, Canada.

The coastal rock pool mosquito, Aedes (Tanakius) togoi (Theobald) (Diptera: Culicidae), is found in coastal east Asia in climates ranging from subtropical to subarctic. However, a disjunct population in the Pacific Northwest of North America has an ambiguous heritage. Two potential models explain the presence of Ae. Read More

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http://dx.doi.org/10.1093/jisesa/ieaa035DOI Listing

Incidence of Cutibacterium acnes from shoulder arthroplasties in Asians: ethnic differences should be considered.

J Shoulder Elbow Surg 2020 May 22. Epub 2020 May 22.

Kyung Hee University Hospital, Seoul, Republic of Korea. Electronic address:

Background: Most studies on Cutibacterium acnes in shoulder surgery have been conducted in the Western population, and studies on Asians are rare. We evaluated the incidence and risk factors of C acnes in shoulder arthroplasty in Asians.

Methods: We retrospectively analyzed 154 patients between January 2017 and May 2019 who underwent shoulder arthroplasty. Read More

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http://dx.doi.org/10.1016/j.jse.2020.02.015DOI Listing

Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease.

J Formos Med Assoc 2020 May 22. Epub 2020 May 22.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

Nontuberculous mycobacterial lung disease (NTM-LD) prevalence has been increasing over the recent decades. Numerous host factors are associated with NTM-LD development, including susceptible phenotypes such as ciliary defect and lung structural change, pulmonary clearance defect with poor clearance of secretions, and immune suppression. Specifically, regarding the susceptible host phenotypes without clear pathogenesis, a slender body, pectus excavatum, and postmenopausal female status are common. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.001DOI Listing

Oral squamous cell carcinoma of the tongue dorsum with multiple cancer-associated mutations in the TP53 gene.

Oral Oncol 2020 May 12:104774. Epub 2020 May 12.

Department of Molecular Oral Medicine and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8553, Kasumi1-2-3, Minami-ku, Hiroshima City, Hiroshima, Japan; Faculty of Allied Health Sciences, University of East Asia, 751-8503, 2-1 Ichinomiyagakuenchō, Shimonoseki-shi, Yamaguchi, Japan.

Objectives: Squamous cell carcinoma (SCC) of the tongue is one of the most common oral cancers, tongue dorsum being a site of low incidence of primary SCC. We report a rare case of SCC of the tongue dorsum in a 69-year-old man having a history of multiple cancers, including esophageal cancer, gastric cancer, and renal cell carcinoma. We discuss the findings in relation to past reports. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104774DOI Listing

Estimates of the global burden of Japanese Encephalitis and the impact of vaccination from 2000-2015.

Elife 2020 May 26;9. Epub 2020 May 26.

Oxford University Clinical Research Unit, Wellcome Trust Asia Program, Ho Chi Minh City, Viet Nam.

Japanese encephalitis (JE) is a mosquito-borne disease, known for its high mortality and disability rate among symptomatic cases. Many effective vaccines are available for JE, and the use of a recently developed and inexpensive vaccine, SA 14-14-2, has been increasing over the recent years particularly with Gavi support. Estimates of the local burden and the past impact of vaccination are therefore increasingly needed, but difficult due to the limitations of JE surveillance. Read More

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http://dx.doi.org/10.7554/eLife.51027DOI Listing

A Statistical Modeling of the Course of COVID-19 (SARS-CoV-2) Outbreak: A Comparative Analysis.

Asia Pac J Public Health 2020 May 25:1010539520928180. Epub 2020 May 25.

Istanbul Medeniyet University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.

This study aims to provide both a model by using cumulative cases and cumulative death toll for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) outbreak in 4 countries, China, Italy, South Korea, and Turkey, starting from the first diagnosis and to compare associated indicators. The most successful estimation was obtained from the cubic model with natural logarithm for China, Italy, South Korea, and Turkey. The success of the models was around 99%. Read More

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http://dx.doi.org/10.1177/1010539520928180DOI Listing

Pomegranate-inspired Silica Nanotags Enable Sensitive Dual-Modal Detection of Rabies Virus Nucleoprotein.

Anal Chem 2020 May 25. Epub 2020 May 25.

The outbreak of rabies virus (RABV) in Asia and Africa has attracted widespread concern due to its 100% mortality rate, and RABV detection is crucial to its diagnosis and treatment. Herein, we report a sensitive and reliable strategy for the dual-modal RABV detection using pomegranate-shaped dendritic silica nanospheres fabricated with densely incorporated quantum dots (QDs) and horseradish peroxidase (HRP) labelled antibody. The immunoassay involves the specific interaction between virus and nanospheres-conjugated antibody, coupled with robust fluorescence signal originating from QDs and naked-eye discernible colorimetric signal on the oxTMB. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c00200DOI Listing

[Acute myocardial infarction secondary to compression of periaortic abscess: a case report].

Zhonghua Xin Xue Guan Bing Za Zhi 2020 May;48(5):422-424

Department of Cardiology, Wuhan Asia Heart Hospital, Wuhan 430022, China.

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http://dx.doi.org/10.3760/cma.j.cn112148-20190512-00241DOI Listing

Detection of African swine fever virus in cell culture and wild boar tissues using a commercially available monoclonal antibody.

J Virol Methods 2020 May 22:113886. Epub 2020 May 22.

Veterinary Diagnostic Directorate, National Food Chain Safety Office, H-1143, Budapest, Tábornok Utca 2, Hungary.

Following the introduction of African swine fever virus (ASFV) into Europe in 2007, ASFV infection has spread continuously over the past years and it became a high level disease threat in Europe and also Asia. Examination of suspect clinical cases for ASF with rapid and sensitive laboratory methods can substantially contribute to the detection and characterization of new outbreaks. In this study two sensitive tests were developed for the detection of the p72 major capsid protein of ASFV both in cell culture with an immunocytochemical (IC) and in tissue samples with an immunohistochemical (IHC) method using a commercially available mouse monoclonal antibody (clone 1BC11). Read More

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http://dx.doi.org/10.1016/j.jviromet.2020.113886DOI Listing

Understanding the Experiences of Health Care-Seeking Migrants in Delhi: Trajectories and Challenges.

Qual Health Res 2020 May 25:1049732320921374. Epub 2020 May 25.

The George Institute for Global Health, New Delhi, India.

Many studies have reported on issues of accessibility and quality of health care among the different vulnerable subgroups in urban locations. To date, no study has been done on the challenges faced by health care-seeking migrants (those traveling to cities for health reasons). This qualitative study used in-depth interviews and nonparticipant observation to examine the health problems, health care-seeking trajectories, and challenges faced by health care-seeking migrants in Delhi, India. Read More

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http://dx.doi.org/10.1177/1049732320921374DOI Listing

Perceptions of Evidence-Based Decision-Making Among Full-Time Teachers and Senior Undergraduates in Public Health: A Nationwide Survey in Taiwan.

Asia Pac J Public Health 2020 May 25:1010539520921723. Epub 2020 May 25.

Taipei Medical University, Taipei, Taiwan.

Using current best evidence to make decisions can improve outcomes of public health. Thus, establishing the capacities of evidence-based public health (EBPH) has become one of the core competences. To better scale up EBPH movement, efforts should focus on introduction of EBPH into school curriculum. Read More

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http://dx.doi.org/10.1177/1010539520921723DOI Listing

De novo assembly and microsatellite marker development of the transcriptome of the endangered Brachymystax lenok tsinlingensis.

Genes Genomics 2020 May 24. Epub 2020 May 24.

Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.

Background: Brachymystax lenok tsinlingensis is an endemic freshwater fish in Northeast Asia, but experienced a dramatic population decline due to over-exploitation, deteriorated habitats and global climate change. It has been listed as a threatened or endangered species in South Korea and China, respectively. However, the conservation and restoration work in wild B. Read More

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http://dx.doi.org/10.1007/s13258-020-00939-3DOI Listing

Autoimmune syndrome induced by adjuvants after breast enhancement with polyacrylamide hydrogel: a study in Poland.

Rheumatol Int 2020 May 24. Epub 2020 May 24.

Department of Plastic Surgery, Prof. W. Orłowski Memorial Hospital, Centre of Postgraduate Medical Education, Czerniakowska 231, 00-416, Warsaw, Poland.

Autoimmune syndrome induced by adjuvants (ASIA) is the spectrum of diseases in which the substances considered inert to the body induce autoimmune reactions and inflammation. Some of the biomaterials recently used in plastic surgery, such as silicone or polyacrylamide hydrogel (PAAG) seem to trigger clinical features of ASIA. The aim of this study was to assess the incidence of these features within a group of women after breast augmentation with PAAG. Read More

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http://dx.doi.org/10.1007/s00296-020-04605-5DOI Listing

Network Pharmacology to Uncover the Molecular Mechanisms of Action of LeiGongTeng for the Treatment of Nasopharyngeal Carcinoma.

Med Sci Monit Basic Res 2020 May 25;26:e923431. Epub 2020 May 25.

Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Radiation Oncology Clinical Medical Research Center of Guangxi, Nanning, Guangxi, China (mainland).

BACKGROUND Nasopharyngeal carcinoma (NPC) is a common head and neck cancer epidemic in southern China and southeast Asia. LeiGongTeng has been widely used for the treatment of cancers. The purpose of this study was to determine the pharmacological mechanism of action of LeiGongTeng in the treatment of NPC using a network pharmacological approach. Read More

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http://dx.doi.org/10.12659/MSMBR.923431DOI Listing

3-Bromofascaplysin is a prospective chemical compound for developing new chemotherapy agents in glioblastoma treatment.

Int Rev Neurobiol 2020 13;151:325-343. Epub 2020 May 13.

Department of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia; Laboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia. Electronic address:

Glioblastoma (GB) is one of the most aggressive human brain tumors. The prognosis is unfavorable, its treatment is relatively ineffective, and the median survival is about 15months. Medication development with new chemical compounds is one of the ways to solve the problem of current treatment inefficiency. Read More

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http://dx.doi.org/10.1016/bs.irn.2020.03.011DOI Listing

Clinical, pathological and parasitological examinations of a German spaniel with alveolar echinococcosis, Germany, 2018.

Vet Parasitol Reg Stud Reports 2020 Apr 21;20:100403. Epub 2020 Mar 21.

Small Animal Clinic, Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 23, 04103 Leipzig, Germany.

Alveolar echinococcosis (AE) is a parasitic zoonosis occurring in most European countries and also emerging in parts of Asia and North America. AE is caused by the larval stage of Echinococcus multilocularis in intermediate and also in accidental hosts. The principal definitive host is the red fox, but domestic dogs and cats are also potential definitive hosts. Read More

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http://dx.doi.org/10.1016/j.vprsr.2020.100403DOI Listing

Variation in mutations providing resistance to acetohydroxyacid synthase inhibitors in Cyperus difformis in China.

Pestic Biochem Physiol 2020 Jun 4;166:104571. Epub 2020 Apr 4.

Key Laboratory of Weed Biology and Management, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No.2 Yuanmingyuan West Road, Beijing 100193, People's Republic of China. Electronic address:

Cyperus difformis has evolved resistance to pyrazosulfuron-ethyl and other acetohydroxyacid synthase (AHAS) inhibitors in paddy fields in China. To understand the distribution of resistance and the mutations involved, 38 populations collected were from 7 provinces and compared. Application of pyrazosulfuron-ethyl at 30 g a. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.104571DOI Listing

Characterization of pyridalyl resistance in a laboratory-selected strain of Frankliniella occidentalis.

Pestic Biochem Physiol 2020 Jun 21;166:104564. Epub 2020 Mar 21.

College of Chemistry, Central China Normal University, Wuhan 430079, China. Electronic address:

Frankliniella occidentalis, the western flower thrips, is one of most notorious pests on a variety of crops worldwide and many populations have high resistance to different types of insecticides. In order to determine the susceptibility of F. occidentalis to the insecticide pyridalyl in the field and to understand the potential mechanism of resistance, we conducted field monitoring of resistance and investigated cross-resistance, fitness cost, and synergism for the 75. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.104564DOI Listing

Insecticidal activity of triterpenoids and volatile oil from the stems of Tetraena mongolica.

Pestic Biochem Physiol 2020 Jun 28;166:104551. Epub 2020 Feb 28.

State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, PR China; Key Laboratory of Herbage and Endemic Crop Biotechnology, School of Life Sciences, Inner Mongolia University, Hohhot 010070, PR China. Electronic address:

Tetraena mongolica Maxim is a species of Zygophyllaceae endemic to China. Because few insect pests affect its growth and flowering, we speculated that this plant produces defensive chemicals that are insect repellents or antifeedants. The effects of different fractions from crude stem and leaf extracts on Pieris rapae were examined. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.02.017DOI Listing

Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium.

BMC Res Notes 2020 May 24;13(1):249. Epub 2020 May 24.

The Medical Practice Evaluation Center, Boston, MA, USA.

Objective: Pediatric antiretroviral therapy (ART) for children with HIV (CHIV) must be dosed appropriately for children's changing weights as they grow. To inform accurate estimates of ART formulations and doses needed, we described weight-for-age distributions among CHIV on ART in the IeDEA global pediatric collaboration between 2004 and 2016, using data from six regions (East, West, Central, and Southern Africa, Asia-Pacific, and Central/South America and the Caribbean).

Results: Overall, 59,862 children contributed to the analysis. Read More

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http://dx.doi.org/10.1186/s13104-020-05081-7DOI Listing

Bear bile use at the intersection of maternal health in Cambodia.

J Ethnobiol Ethnomed 2020 May 24;16(1):28. Epub 2020 May 24.

San Diego Zoo Institute for Conservation Research, 15600 San Pasqual Valley Rd, Escondido, CA, 92026, USA.

Background: The consumption of bear gallbladders and bear bile in Southeast Asia is a persistent threat to bear populations. As part of a larger effort to understand the characteristics of bear part consumption in Cambodia, we uncovered a consumer base of women seeking treatment for post-partum and uterine ailments.

Methods: To better understand this aspect of consumption, we interviewed 122 women in seven different provinces in Cambodia, probing into the motivations and influences for using bear bile, as well as what types of ailments Cambodian women use it for. Read More

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http://dx.doi.org/10.1186/s13002-020-00380-6DOI Listing

The burden of adolescent motherhood and health consequences in Nepal.

BMC Pregnancy Childbirth 2020 May 24;20(1):318. Epub 2020 May 24.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Background: Annually, 18 million babies are born to mothers 18 years or less. Two thirds of these births take place in South Asia and Sub-Saharan Africa. Due to social and biological factors, adolescent mothers have a higher risk of adverse birth outcomes. Read More

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http://dx.doi.org/10.1186/s12884-020-03013-8DOI Listing

Molecular assessment of kelch13 non-synonymous mutations in Plasmodium falciparum isolates from Central African Republic (2017-2019).

Malar J 2020 May 24;19(1):191. Epub 2020 May 24.

Unité Génétique du Paludisme et Résistance, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 25-28 Rue du Dr Roux, 75015, Paris, France.

Background: Over the last decade, artemisinin-based combination therapy (ACT) has contributed substantially to the decrease in malaria-related morbidity and mortality. The emergence of Plasmodium falciparum parasites resistant to artemisinin derivatives in Southeast Asia and the risk of their spread or of local emergence in sub-Saharan Africa are a major threat to public health. This study thus set out to estimate the proportion of P. Read More

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http://dx.doi.org/10.1186/s12936-020-03264-yDOI Listing

Text mining in a literature review of urothelial cancer using topic model.

BMC Cancer 2020 May 24;20(1):462. Epub 2020 May 24.

Division of Nephrology, Asia University Hospital, Taichung, Taiwan.

Background: Urothelial cancer (UC) includes carcinomas of the bladder, ureters, and renal pelvis. New treatments and biomarkers of UC emerged in this decade. To identify the key information in a vast amount of literature can be challenging. Read More

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http://dx.doi.org/10.1186/s12885-020-06931-0DOI Listing

[Clinical and coagulation characteristics in 7 patients with critical COVID-2019 pneumonia and acro-ischemia].

Zhonghua Xue Ye Xue Za Zhi 2020 Apr;41(4):302-307

Department of Infection Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

To investigate the clinical and coagulation characteristics in patients with critical Coronavirus disease 2019 (COVID-19) and acro-ischemia. The retrospective study included 7 critical COVID-19 patients with acro-ischemia in an intensive care unit (ICU) in Wuhan, from Feb 4 to Feb 15, 2020. The clinical and laboratory data before and during the ICU stay were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.008DOI Listing

Clinical practice guidance for hepatology and liver transplant providers during the COVID-19 pandemic: APASL expert panel consensus recommendations.

Hepatol Int 2020 May 23. Epub 2020 May 23.

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: Confronting a once-in-a-century pandemic with COVID-19, tremendous stress has been placed in all walks of life worldwide.

Aims: In order to enhance scientific information interflow in the arena of liver diseases in Asia-Pacific region during this difficult time, Asian-Pacific Association for the Study of the Liver (APASL) has taken the initiative to form the APASL COVID-19 Taskforce to formulate a clinical practice guidance in Hepatology, liver-related oncology, transplantation and conduct of clinical trials.

Methods: A taskforce with 22 key opinion leaders in Hepatology from 16 countries or administration regions in Asia-Pacific regions was formed and through intense interaction via webinar, this guidance was formulated. Read More

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http://dx.doi.org/10.1007/s12072-020-10054-wDOI Listing

Changes in mycorrhizal status and type in plant communities along altitudinal and ecological gradients-a case study from the Northern Urals (Russia).

Mycorrhiza 2020 May 23. Epub 2020 May 23.

Institute of Biology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.

The Ural Mountains (the Urals) are a mountain range on the border between the continents of Europe and Asia. The Urals extend about 2500 km from north to south and run from the coast of the Arctic Ocean to the steppe of northwestern Kazakhstan. In terms of mycorrhizal traits, the vegetation of the Urals has not been studied absolutely compared with the other mountain systems of Europe. Read More

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http://dx.doi.org/10.1007/s00572-020-00961-zDOI Listing

Transcriptomic and biochemical analyses of the accumulation of sucrose in mungbean (Vigna radiata (L.) Wilczek) leaves after pod removal.

Theor Appl Genet 2020 May 23. Epub 2020 May 23.

Plant Genomics and Breeding Institute, Seoul National University, Seoul, 08826, Republic of Korea.

Key Message: Synchronous pod maturity is critical for increasing grain yield. The candidate genes involved in synchronous pod maturity were identified through RNA-seq and HPLC. Mungbean (Vigna radiata [L. Read More

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http://dx.doi.org/10.1007/s00122-020-03603-2DOI Listing

Construction of 5G all-wireless network and information system for cabin hospital.

J Am Med Inform Assoc 2020 May 24. Epub 2020 May 24.

Department of Computer Management, Wuhan Asia General Hospital, Wuhan, China.

The epidemic of coronavirus disease 2019 (COVID-19) broke out in Wuhan, China, in early 2020. In an effort to curb the spread of the epidemic, the government has requisitioned a variety of venues and plant buildings and built more than 20 cabin hospitals to receive patients with mild symptoms within 48 hours. Under this circumstance, we worked out a 5G all-wireless solution to divide the overall network system of the cabin hospital into multiple network units by function. Read More

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http://dx.doi.org/10.1093/jamia/ocaa045DOI Listing

Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein.

Phytomedicine 2020 May 16;71:153239. Epub 2020 May 16.

Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan 40402, R.O.C.; Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan 40447, R.O.C.. Electronic address:

Background And Purpose: Multidrug resistance (MDR) remains the main obstacle in cancer treatment and overexpression of P-glycoprotein (P-gp) is one of the most common causes of chemoresistance. The development of novel P-gp inhibitors from natural products is a prospective strategy to combat MDR cancers. Among the natural sesquiterpene compounds, sesquiterpene pyridine alkaloids exhibit various biological properties. Read More

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http://dx.doi.org/10.1016/j.phymed.2020.153239DOI Listing
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