680 results match your criteria Asia Life Sciences[Journal]


Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in China: a nation-wide study.

Sci China Life Sci 2022 May 5. Epub 2022 May 5.

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 518038, China.

Lockdown and re-opening may become cyclical due to the recurrent waves of the COVID-19 epidemic. Few studies have examined temporal trends and determinants of in-hospital mortality among patients with ST-segment elevation myocardial infarction (STEMI), a life-threatening condition that requires emergency medical care. Using nation-wide data before, during and after the Wuhan lockdown, we aimed to depict temporal patterns and major determinants of STEMI in-hospital mortality in China across five time periods of the COVID-19 epidemic. Read More

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Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA.

Sci China Life Sci 2022 Apr 21. Epub 2022 Apr 21.

Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410083, China.

Nasopharyngeal carcinoma (NPC) is a malignant tumor that usually occurs in people from Southeast Asia and Southern China. NPC is prone to migration and invasion, leading to poor prognosis. A large number of circular RNAs (circRNAs) exacerbate the process of metastasis in NPC; however, their underlying mechanisms remain unclear. Read More

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Ancient genomes reveal the genetic inheritance and recent introgression in Chinese indigenous pigs.

Sci China Life Sci 2022 04 17;65(4):842-845. Epub 2022 Feb 17.

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang, 712100, China.

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EphrinB2/ephB2 activation facilitates colonic synaptic potentiation and plasticity contributing to long-term visceral hypersensitivity in irritable bowel syndrome.

Life Sci 2022 Apr 17;295:120419. Epub 2022 Feb 17.

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Aims: Sustained visceral hypersensitivity is a hallmark of irritable bowel syndrome (IBS) could be partially explained by enteric neural remodeling. Particularly, synaptic plasticity in the enteric nervous system, a form of enteric "memory", has been speculated as a participant in the pain maintenance in IBS. This study aimed to elucidate the role of ephrinB2/ephB2 in enteric synaptic plasticity and visceral pain in IBS. Read More

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Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality.

Sci China Life Sci 2022 May 8;65(5):861-895. Epub 2022 Feb 8.

State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.

Enhancing the terrestrial ecosystem carbon sink (referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide (CO) concentration and to achieve carbon neutrality target. To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality, this review summarizes major progress in terrestrial C budget researches during the past decades, clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world, and examines the role of terrestrial C sinks in achieving carbon neutrality target. According to recent studies, the global terrestrial C sink has been increasing from a source of (-0. Read More

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Preclinical efficacy and involvement of mTOR signaling in the mechanism of Orf virus against nasopharyngeal carcinoma cells.

Life Sci 2022 Feb 8;291:120297. Epub 2022 Jan 8.

Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong, PR China; Key Laboratory of Antibody Engineering of Guangdong Higher Education Institutes, Southern Medical University, Guangzhou 510515, Guangdong, PR China. Electronic address:

Aims: Orf virus (ORFV) is a parapoxvirus causing contagious ecthyma in sheep and goats. With inhibitory role of ORFV reported by previous studies, ORFV can be a candidate of oncolytic virus. However, few studies reported the application and mechanism of ORFV in nasopharyngeal carcinoma (NPC). Read More

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February 2022

Arborinine suppresses ovarian cancer development through inhibition of LSD1.

Life Sci 2022 Feb 31;291:120275. Epub 2021 Dec 31.

Department of Gynecology, the Second Hospital of Hebei Medical University, No.215 Heping West Road, Shijiazhuang 050000, Hebei, China.

Aims: Epithelial ovarian carcinoma is the most lethal female reproductive malignancy in the world. Paclitaxel and carboplatin are generally the first-line treatment drugs for ovarian cancer patients, but numerous patients may develop chemotherapy resistance. Thus, it is urgent to identify novel drugs for ovarian cancer treatment. Read More

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February 2022

Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6.

Life Sci 2022 Feb 29;290:120266. Epub 2021 Dec 29.

Engineering Research Center of Coptis Development & Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China. Electronic address:

Aim: Gastric cancer is a prevalent malignant tumor that seriously affects human health. Berberine (BBR), an alkaloid from Chinese herbal medicines, inhibits the proliferation of various cancers. We evaluated the effects and related mechanisms of BBR on gastric cancer. Read More

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February 2022

Inhibition of EZH2 ameliorates hyperoxaluria-induced kidney injury through the JNK/FoxO3a pathway.

Life Sci 2022 Feb 21;291:120258. Epub 2021 Dec 21.

Department of Urology, Changhai Hospital, Navy Medical University, Shanghai, China. Electronic address:

Aims: Enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 methyltransferase, has been shown to play a role in kidney diseases. However, its role in hyperoxaluria-induced renal tubular epithelial cells (TECs) injury remains unclear.

Materials And Methods: A hyperoxaluria rat model was established by providing 0. Read More

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February 2022

Prevalence and molecular epidemiology of equine piroplasmosis in China: a neglected tick-borne disease.

Sci China Life Sci 2022 02 16;65(2):445-447. Epub 2021 Dec 16.

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.

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February 2022

Preface to the special topic on tissue stem cell research.

Sci China Life Sci 2021 12 30;64(12):1995-1997. Epub 2021 Nov 30.

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.

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December 2021

Cancer challenges worldwide and in China: preparing for the inevitable.

Sci China Life Sci 2022 02 19;65(2):442-444. Epub 2021 Nov 19.

Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.

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February 2022

Profile of Prof. Qi Wang.

Authors:

Sci China Life Sci 2021 12;64(12):2088-2091

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December 2021

Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China.

Sci China Life Sci 2022 04 8;65(4):795-808. Epub 2021 Nov 8.

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.

The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Read More

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An analysis of the biopharmaceutical behaviour of proton pump inhibitors with different physicochemical properties.

Life Sci 2021 Dec 19;286:120042. Epub 2021 Oct 19.

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. Electronic address:

At present, little information on the biopharmaceutical behaviour of proton pump inhibitors (PPIs) describing their absorption and biodistribution in vivo has been reported because the extreme instability of PPIs in the gastrointestinal environment makes it difficult to analyze such behaviour. In this work, a modified rat in situ intestinal perfusion model was employed to investigate absorption in the gastrointestinal tract and subsequent biodistribution of several PPIs (ilaprazole, esomeprazole and rabeprazole), which have different physicochemical properties. Our data indicated that PPIs exhibited significantly enhanced absorption rates in the whole intestine, including the duodenum, jejunum, ileum and colon, corresponding to the increase in the oil-water partition coefficient (LogP). Read More

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December 2021

FILIP1L-mediated cell apoptosis, epithelial-mesenchymal transition and extracellular matrix synthesis aggravate posterior capsular opacification.

Life Sci 2021 Dec 16;286:120061. Epub 2021 Oct 16.

Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address:

Aims: The epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) synthesis and cell migration of residual lens cells constitute the canonical mechanisms of posterior capsular opacification (PCO). Recently, myofibroblast cell apoptosis is also observed in the rabbit PCO model. However, whether cell apoptosis is a key factor affecting PCO and regulates EMT/ECM synthesis/cell migration remains obscure. Read More

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December 2021

Cerebralcare Granule® combined with nimodipine improves cognitive impairment in bilateral carotid artery occlusion rats by reducing lipocalin-2.

Life Sci 2021 Dec 13;286:120048. Epub 2021 Oct 13.

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 3000721, China. Electronic address:

Aims: Clinically, Cerebralcare Granule® (CG) has been widely utilized to treat various types of headache, chronic cerebral insufficiency and other diseases, and the effect is significant. Clinical studies have shown that CG can significantly relieve vascular dementia (VaD), however, the molecular mechanisms haven't been established. To clear the therapeutic mechanisms of CG against VaD, a hypothesis was proposed that CG could treat neurovascular injury by inhibiting the production of lipocalin-2 (LCN 2). Read More

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December 2021

Palmitic acid inhibits prostate cancer cell proliferation and metastasis by suppressing the PI3K/Akt pathway.

Life Sci 2021 Dec 12;286:120046. Epub 2021 Oct 12.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; School of Medicine, Tianjin Tianshi College, Tianyuan University, Tianjin 301700, China. Electronic address:

Aims: Prostate cancer is one of the most frequent causes of cancer death in men worldwide, and novel drugs for prostate cancer therapies are still being developed. Palmitic acid is a common saturated long-chain fatty acid that is known to exhibit anti-inflammatory and metabolic regulatory effects and antitumor activities in several types of tumors. The present study aims to explore the antiproliferative and antimetastatic activities of palmitic acid on human prostate cancer cells and the underlying mechanism. Read More

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December 2021

Emergence of a novel reassortant avian influenza virus (H10N3) in Eastern China with high pathogenicity and respiratory droplet transmissibility to mammals.

Sci China Life Sci 2022 May 17;65(5):1024-1035. Epub 2021 Sep 17.

College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.

Decades have passed since the first discovery of H10-subtype avian influenza virus (AIV) in chickens in 1949, and it has been detected in many species including mammals such as minks, pigs, seals and humans. Cases of human infections with H10N8 viruses identified in China in 2013 have raised widespread attention. Two novel reassortant H10N3 viruses were isolated from chickens in December 2019 in eastern China during routine surveillance for AIVs. Read More

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Profile of Dr. Songlin Wang.

Authors:

Sci China Life Sci 2021 Nov;64(11):1810-1813

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November 2021

Profile of Dr. Hong-Bing Shen.

Authors:

Sci China Life Sci 2022 01;65(1):16-18

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January 2022

Nutrition status of patients with common cancer in China: gap, mission and challenge.

Sci China Life Sci 2021 Nov 16;64(11):1980-1983. Epub 2021 Aug 16.

Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

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November 2021

Whole-exome sequencing reveals genetic risks of early-onset sporadic dilated cardiomyopathy in the Chinese Han population.

Sci China Life Sci 2022 04 22;65(4):770-780. Epub 2021 Jul 22.

Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

To reveal genetic risks of early-onset sporadic dilated cardiomyopathy (DCM) patients in the Chinese Han population, we enlisted 363 DCM cases and 414 healthy controls. Whole-exome sequencing and phenotypic characterization were conducted. In total, we identified 26 loss-of-function (LOF) candidates and 66 pathogenic variants from 33 genes, most of which were novel. Read More

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Profile of Dr. Daoxin Xie.

Authors:

Sci China Life Sci 2021 Aug;64(8):1212-1214

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Huangjing (Polygonati rhizoma) is an emerging crop with great potential to fight chronic and hidden hunger.

Sci China Life Sci 2021 Sep 17;64(9):1564-1566. Epub 2021 Jun 17.

State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, 311300, China.

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September 2021

Susceptibility of patients with chronic obstructive pulmonary disease to heart rate difference associated with the short-term exposure to metals in ambient fine particles: A panel study in Beijing, China.

Sci China Life Sci 2022 02 13;65(2):387-397. Epub 2021 May 13.

State Key Joint Laboratory for Environmental Simulation and Pollution Control and Beijing Innovation Center for Engineering Science and Advanced Technology, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.

Susceptibility of patients with chronic obstructive pulmonary disease (COPD) to cardiovascular autonomic dysfunction associated with exposure to metals in ambient fine particles (PM, particulate matter with aerodynamic diameter ≤2.5 µm) remains poorly evidenced. Based on the COPDB (COPD in Beijing) panel study, we aimed to compare the associations of heart rate (HR, an indicator of cardiovascular autonomic function) and exposure to metals in PM between 53 patients with COPD and 82 healthy controls by using linear mixed-effects models. Read More

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February 2022

Phenotypic and genetic characterization of novel variant in the NF1 gene underlying neurofibromatosis type 1 in five Chinese families.

Sci China Life Sci 2021 12 13;64(12):2206-2209. Epub 2021 May 13.

McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China.

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December 2021

Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.

Life Sci 2021 Jul 10;277:119592. Epub 2021 May 10.

Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

Background: Hepatocellular carcinoma (HCC) is one of the common malignancies worldwide. Slit-Robo GTPase-activating proteins (SRGAPs) have been shown to regulate the occurrence and development of various tumors. However, their specific roles in HCC remain elusive. Read More

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PTTG1 knockdown enhances radiation-induced antitumour immunity in lung adenocarcinoma.

Life Sci 2021 Jul 11;277:119594. Epub 2021 May 11.

Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital, PR China. Electronic address:

Aim: Ionizing radiation (IR) can induce local and systemic antitumour immune responses to some degree and augment immunotherapeutic efficacy. IR may also increase residual tumour cell invasion and elicit immunosuppression in the tumour microenvironment (TME). It remains poorly understand, whether IR leads to immune negative response or invasive capacity increases in lung adenocarcinoma (LAC). Read More

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