3,882 results match your criteria Aseptic Meningitis


Murine typhus Presenting with Status Epilepticus.

Int J Infect Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of General Medicine, Changi General Hospital, 2 Simei Street 3, 529889 Singapore.

Patients with rickettsial infection usually present with a febrile illness, headache, arthromyalgia and various biochemical abnormalities. Neurologic involvement is rare in murine typhus. Here, we report a case of a patient who presented with status epilepticus secondary to Rickettsia typhi infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193018
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http://dx.doi.org/10.1016/j.ijid.2019.04.012DOI Listing
April 2019
1 Read

A Case of Reversible Cerebral Vasoconstriction Syndrome Triggered by High-Dose Methotrexate in a Boy With Lymphoma.

Headache 2019 Apr 15. Epub 2019 Apr 15.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by thunderclap headaches and transient segmental cerebral arterial vasoconstriction. Many drugs have been identified as triggers of RCVS. However, RCVS induced by methotrexate (MTX), an antimetabolite agent, has never been reported. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/head.13526
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http://dx.doi.org/10.1111/head.13526DOI Listing
April 2019
6 Reads

Spectrum of the neurologic manifestations in childhood-onset cryopyrin-associated periodic syndrome.

Eur J Paediatr Neurol 2019 Mar 28. Epub 2019 Mar 28.

Department of Pediatric Neurology, Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey.

Objective: Neurologic complications of chronic infantile neurologic, cutaneous and articular syndrome (CINCA) are well-known, whereas there are scarce data regarding neurologic features of milder cryopyrin-associated periodic syndrome (CAPS) phenotypes. We aimed to review the neurologic features in detail and summarize the other CAPS-related manifestations in 12 children.

Methods: All children with CAPS that have been followed-up from pediatric rheumatology outpatient clinic, were enrolled to the study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183056
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http://dx.doi.org/10.1016/j.ejpn.2019.03.006DOI Listing
March 2019
2 Reads

The missing link between familial Mediterranean fever and recurrent aseptic meningitis.

Pediatr Neonatol 2019 Mar 20. Epub 2019 Mar 20.

Assistance Publique - Hôpitaux de Paris, Hôpital Tenon, Service de médecine interne, F-75020, Paris, France.

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http://dx.doi.org/10.1016/j.pedneo.2019.03.007DOI Listing
March 2019
6 Reads

A case of acute posterior multifocal placoid pigment epitheliopathy with aseptic meningitis and cerebral infarction.

Rev Neurol (Paris) 2019 Mar 27. Epub 2019 Mar 27.

Service de neurologie, hôpitaux universitaires de Strasbourg, 67000 Strasbourg, France; Inserm U1434, centre d'investigation clinique, 67000 Strasbourg, France; Inserm U1119, biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, fédération de médecine translationnelle de Strasbourg, 67000 Strasbourg, France.

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http://dx.doi.org/10.1016/j.neurol.2018.06.011DOI Listing

Clinical Characteristics of Saffold Virus Infection in Children.

Pediatr Infect Dis J 2019 Mar 21. Epub 2019 Mar 21.

Department of Pediatrics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Background: Saffold virus (SAFV) is a novel human cardiovirus that was identified in 2007. Recently, SAFV has been isolated from nasal and stool specimens of infants presenting with respiratory and gastrointestinal symptoms and from cerebrospinal fluid (CSF) specimens of children with central nervous system infection. However, little is known regarding clinical characteristics of SAFV in children. Read More

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http://dx.doi.org/10.1097/INF.0000000000002298DOI Listing
March 2019
12 Reads

Intrathecal Trastuzumab as a Potential Cause of Drug-Induced Aseptic Meningitis.

Can J Neurol Sci 2019 Mar 25:1-2. Epub 2019 Mar 25.

AP-HP,Hôpitaux Universitaires Pitié Salpêtrière -- Charles Foix,Service de Neurologie 2-Mazarin, Paris F-75013,France.

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http://dx.doi.org/10.1017/cjn.2019.21DOI Listing
March 2019
1 Read

How We Treat Autoimmune Small Fiber Polyneuropathy with Immunoglobulin Therapy.

Eur Neurol 2018 19;80(5-6):304-310. Epub 2019 Mar 19.

Eastern Virginia Medical School, Norfolk, Virginia, USA.

Intravenous immunoglobulin therapy is FDA approved for the immune-mediated peripheral nerve disorders Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. Immunoglobulin therapy has been used increasingly with significant efficacy in the treatment of patients with disabling autoimmune forms of dysautonomia, which are most often small fiber (autonomic and/or sensory) polyneuropathies. It is recognized by most who treat these disorders, however, that patients with autonomic dysfunction treated with intravenous immunoglobulin therapy develop aseptic meningitis or severe lingering headache more frequently than other patient populations when this therapy is dosed in the traditional fashion. Read More

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http://dx.doi.org/10.1159/000498858DOI Listing
March 2019
1 Read

Essential role of enterovirus 2A protease in counteracting stress granule formation and the induction of type I interferon.

J Virol 2019 Mar 13. Epub 2019 Mar 13.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

Most viruses have acquired mechanisms to suppress antiviral IFN-α/β and stress responses. Enteroviruses actively counteract the induction of IFN-α/β gene transcription and stress granule (SG) formation, which are increasingly implicated as a platform for antiviral signaling, but the underlying mechanisms remain poorly understood. Both viral proteases (2A and 3C) have been implicated to suppress these responses, but these conclusions predominantly rely on ectopic overexpression of viral proteases or addition of purified viral proteases to cell lysates. Read More

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http://dx.doi.org/10.1128/JVI.00222-19DOI Listing
March 2019
6 Reads

Interactions Between Enteroviruses and the Inflammasome: New Insights Into Viral Pathogenesis.

Front Microbiol 2019 25;10:321. Epub 2019 Feb 25.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Enteroviruses (EVs) have emerged a substantial threat to public health. EVs infection range from mild to severe disease, including mild respiratory illness, diarrhea, poliomyelitis, hand, foot, and mouth disease, aseptic meningitis, and encephalitis. In the Asia-Pacific region, for example, one of the best studied enterovirus 71 (EV71) has been associated with pandemics of hand, foot, and mouth disease (HFMD) in children, particularly those under the age of five. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398425PMC
February 2019
2 Reads

Global phylodynamics of Echovirus 30 revealed differential behavior among viral lineages.

Virology 2019 Feb 18;531:79-92. Epub 2019 Feb 18.

Institute of Biotechnology and Molecular Biology, CONICET-UNLP, 1900 La Plata, Argentina. Electronic address:

Echovirus 30 (E30) is an important causative agent of aseptic meningitis worldwide. Despite this, the global and regional dispersion patterns, especially in South America, are still largely unknown. We performed an in-depth analysis of global E30 population dynamics, by using the VP1 sequences of 79 strains isolated in Argentina, between 1998 and 2012, and 856 sequences from GenBank. Read More

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http://dx.doi.org/10.1016/j.virol.2019.02.012DOI Listing
February 2019
2 Reads

Atypical spinal endodermal cyst presenting with contralateral C2 neuralgia and aseptic meningitis.

Radiol Case Rep 2019 May 27;14(5):561-564. Epub 2019 Feb 27.

Department of Neurological Surgery, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan.

A previously healthy 43-year-old man presented with durable occipitalgia for 1 month. Neurological examination revealed severe pain in the right C2 area accompanied by neck stiffness. Magnetic resonance imaging revealed an enhancing, polycystic intradural mass at the C2 level, occupying the left dorsolateral part of the spinal canal. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393700PMC
May 2019
1 Read

The neonatal Fc receptor is a pan-echovirus receptor.

Proc Natl Acad Sci U S A 2019 02 11;116(9):3758-3763. Epub 2019 Feb 11.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224;

Echoviruses are amongst the most common causative agents of aseptic meningitis worldwide and are particularly devastating in the neonatal population, where they are associated with severe hepatitis, neurological disease, including meningitis and encephalitis, and even death. Here, we identify the neonatal Fc receptor (FcRn) as a pan-echovirus receptor. We show that loss of expression of FcRn or its binding partner beta 2 microglobulin (β2M) renders cells resistant to infection by a panel of echoviruses at the stage of virus attachment, and that a blocking antibody to β2M inhibits echovirus infection in cell lines and in primary human intestinal epithelial cells. Read More

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http://dx.doi.org/10.1073/pnas.1817341116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397586PMC
February 2019
2 Reads

Molecular Epidemiology of Echovirus 18 Circulating in Mainland China from 2015 to 2016.

Virol Sin 2019 Feb 21;34(1):50-58. Epub 2019 Feb 21.

Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Echovirus 18 (E18), a serotype of Enterovirus B (EV-B) species, is an important pathogen in aseptic meningitis. E18 had rarely been detected in mainland China, but became the predominant pathogen associated with viral encephalitis (VE) and meningitis in Hebei province for the first time in 2015. To investigate the molecular epidemiology and genetic characteristics of E18 in mainland China, sixteen E18 strains from patient throat swabs with hand, foot, and mouth disease (HFMD) in six provinces in China collected between 2015 and 2016, and four E18 strains isolated from 18 patient cerebrospinal fluid specimens with VE in Hebei Province in 2015 were obtained and sequenced. Read More

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http://dx.doi.org/10.1007/s12250-018-0080-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420525PMC
February 2019
3 Reads

Severe cryopyrin-associated periodic syndrome first characterized by early childhood-onset sensorineural hearing loss - Case report and literature review.

Int J Pediatr Otorhinolaryngol 2019 May 28;120:68-72. Epub 2019 Jan 28.

Division of Pediatric Rheumatology, Department of Pediatrics, IWK Health Centre, 5850/5980 University Ave, PO Box 9700, Halifax, NS, B3K 6R8, Canada. Electronic address:

Infant-onset bilateral sensorineural hearing loss is a key presenting symptom of the autoinflammatory cryopyrin-associated periodic syndrome. Other symptoms include periodic fever, cold-induced urticaria-like rash, chronic aseptic meningitis, polyarticular arthralgias, and renal AA amyloidosis. Early recognition and treatment with interleukin-1 blockade are critical for preventing disabling or fatal complications. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.037DOI Listing
May 2019
2 Reads

Impact of the introduction of the Haemophilus influenzae type b conjugate vaccine in an urban setting in southern India.

Vaccine 2019 Mar 14;37(12):1608-1613. Epub 2019 Feb 14.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21218, USA.

Introduction: Haemophilus influenzae type b was the leading cause of bacterial meningitis in infants and children below the age of two years prior to the introduction of H. influenzae type b conjugate vaccines. In December 2011, the Indian government introduced H. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.080DOI Listing
March 2019
1 Read

Zika Virus-Associated Aseptic Meningitis and Guillain-Barre Syndrome in a Traveler Returning from Latin America: a Case Report and Mini-Review.

Curr Infect Dis Rep 2019 Feb 15;21(1). Epub 2019 Feb 15.

Department of Medicine, University of Toronto, Toronto, Canada.

ZIKV-associated Guillain-Barré syndrome presents with an accelerated clinical course compared to classic post-infectious Guillain-Barré syndrome. Clinicians should anticipate and screen patients with ZIKV infection for neurologic complications bearing in mind that these may manifest during the acute viremic phase or during early convalescence. Read More

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http://dx.doi.org/10.1007/s11908-019-0661-1DOI Listing
February 2019
1 Read

Vogt-Koyanagi-Harada Disease, a Rare Entity in Spain: The Challenge of Worldwide Immigration and Globalization.

Eur J Case Rep Intern Med 2018 26;5(7):000886. Epub 2018 Jul 26.

Ophthalmology Department, Baza Hospital, Granada, Spain.

Vogt-Koyanagi-Harada disease is rare, mediated by autoimmune melanocyte inflammation and facilitated by genetic predisposition. The main clinical features include uveitis, meningitis, tinnitus and sensorineural deafness, and skin and hair depigmentation. It usually develops in four consecutive stages: prodromal, acute uveitic, convalescent, and chronic or recurrent. Read More

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http://dx.doi.org/10.12890/2018_000886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346778PMC

Posterior fossa decompression for Chiari malformation type I: clinical and radiological presentation, outcome and complications in a retrospective series of 105 procedures.

Acta Neurol Belg 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurosurgery, University Hospitals, Leuven, Belgium.

Objective: Determining clinical and radiological characteristics, complication rates and outcome for patients undergoing posterior fossa decompression (PFD) and duraplasty for Chiari malformation type I (CM-I).

Methods And Materials: Retrospective, single-university hospital study of all PFDs for CM-I between January 1995 and December 2016.

Results: PFD was performed in 105 patients with CM-I (n = 105), of whom 62 suffered from associated syringomyelia and 37 were pediatric cases. Read More

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http://dx.doi.org/10.1007/s13760-019-01086-7DOI Listing
February 2019
4 Reads

Viral (aseptic) meningitis: A review.

J Neurol Sci 2019 Mar 31;398:176-183. Epub 2019 Jan 31.

Division of Hospital Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pinnacle, United States.

Viral meningitis is an inflammation of the meninges associated with acute onset of meningeal symptoms and fever, pleocytosis of the cerebrospinal fluid, and no growth on routine bacterial culture. It is sometimes associated with viral encephalitis and meningoencephalitis. Viruses reach the central nervous system (CNS) hematogenously or in a retrograde manner from nerve endings. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.050DOI Listing
March 2019
2 Reads

Immunogenicity and safety of the new MMR vaccine containing measles AIK-C, rubella Takahashi, and mumps RIT4385 strains in Japanese children: a randomized phase I/II clinical trial.

Hum Vaccin Immunother 2019 Feb 6. Epub 2019 Feb 6.

b Japan Vaccine Co., Ltd .

Domestic measles, mumps, and rubella combined (MMR) vaccines were discontinued in 1993 in Japan because of the unexpected high incidence of aseptic meningitis. The introduction of an effective MMR vaccine with lower reactogenicity has been expected. A new MMR vaccine (JVC-001) was developed, using mumps RIT4385 strain in combination with Japanese measles AIK-C strain and rubella Takahashi strain (MR) vaccine. Read More

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http://dx.doi.org/10.1080/21645515.2019.1578591DOI Listing
February 2019
8 Reads

Opsoclonus in a child with neuroborreliosis: Case report and review of the literature.

Arch Pediatr 2019 Feb 14;26(2):118-119. Epub 2019 Jan 14.

Service de neurologie pédiatrique, CHU d'Angers, 4, rue Larrey, 49100 Angers, France.

Opsoclonus consists of massive erratic rapid eye jerks. They may occur in isolation or in association with myoclonus and ataxia, i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0929693X183026
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http://dx.doi.org/10.1016/j.arcped.2018.11.013DOI Listing
February 2019
8 Reads

Aseptic meningitis as onset of Kawasaki disease.

Minerva Pediatr 2019 Jan 17. Epub 2019 Jan 17.

First Division of Infectious Disease, Cotugno Hospital, Azienda Ospedaliera dei Colli, Naples, Italy.

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http://dx.doi.org/10.23736/S0026-4946.19.05384-2DOI Listing
January 2019
7 Reads

Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Jan 10. Epub 2019 Jan 10.

Department of Children's Oncology, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic.

Aims: Enteroviruses (EVs) are the most common agents of aseptic meningitis. Some serotypes can cause serious neuroinfection leading to death. The aim of this study was to determine the representation of EVs in the etiology of aseptic meningitis in children and to analyze the demographic, clinical, laboratory, and epidemiological characteristics of patients with EV meningitis. Read More

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http://biomed.papers.upol.cz/doi/10.5507/bp.2018.082.html
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http://dx.doi.org/10.5507/bp.2018.082DOI Listing
January 2019
18 Reads

Acute transverse myelitis - A rare clinical manifestation of Lyme neuroborreliosis.

IDCases 2019 29;15:e00479. Epub 2018 Dec 29.

Division of Infectious Diseases, North Memorial Health Hospital, Minneapolis, MN, United States.

Acute transverse myelitis (ATM) is a rare, potentially devastating neurological syndrome that has variety of causes, infectious being one of them. Lyme disease (LD) is the most common vector borne zoonosis in the United States (U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22142509183019
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http://dx.doi.org/10.1016/j.idcr.2018.e00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317275PMC
December 2018
10 Reads

Kawasaki disease shock syndrome: clinical characteristics and possible use of IL-6, IL-10 and IFN-γ as biomarkers for early recognition.

Pediatr Rheumatol Online J 2019 Jan 5;17(1). Epub 2019 Jan 5.

Department of Rheumatology Immunology and Allergy, Children's Hospital, Zhejiang University School of Medicine, No.57, Zhugan Lane, Yan-an Road, Hangzhou, 310003, China.

Background: As an acute febrile and inflammatory disease, Kawasaki disease (KD) could develop Kawasaki disease shock syndrome (KDSS) sometimes. However its pathogenesis was still not well known. This study was to learn more about the clinical features and evaluate the role of cytokines in the pathogenesis of KDSS. Read More

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http://dx.doi.org/10.1186/s12969-018-0303-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321686PMC
January 2019
7 Reads

Echovirus plays a major role in natural recombination in the coxsackievirus B group.

Arch Virol 2019 Mar 1;164(3):853-860. Epub 2019 Jan 1.

Medical College, Jiangsu University, 301 Xuefu road, Zhenjiang, 212013, People's Republic of China.

Coxsakievirus (CV) B4, CVB5, and CVA9 belong to the species Enterovirus B. These viruses can cause viral encephalitis, aseptic meningitis, pancreatitis, flaccid paralysis, dilated myocarditis, and hand, foot, and mouth disease (HFMD). In order to analyze the evolution of CVB4, CVB5, and CVA9, we analyzed all of the available genome sequences of Enterovirus B (EVB) isolates and found that there were 12 putative recombination events that produced CVB4, 13 putative recombination events that produced CVB5, and 10 putative recombination events that produced CVA9. Read More

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http://dx.doi.org/10.1007/s00705-018-4114-1DOI Listing
March 2019
3 Reads

Rheumatoid meningitis sine arthritis.

J Neuroimmunol 2019 Mar 19;328:73-75. Epub 2018 Dec 19.

Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Address: 211 South 9(th) Street, Walnut Towers Suite 210, Philadelphia, PA 19107, United States. Electronic address:

Rheumatoid meningitis is a rare and very serious extra-articular manifestation of rheumatoid arthritis. We present a case of a 7()year-old female with no history of arthritis who developed stroke-like symptoms, seizures, psychosis and compulsive behavior. Serial brain magnetic resonance images (MRI) over four months demonstrated progressive interhemispheric meningeal thickening. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183048
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http://dx.doi.org/10.1016/j.jneuroim.2018.12.001DOI Listing
March 2019
5 Reads

Molecular characterization of an outbreak of enterovirus-associated meningitis in Mossel Bay, South Africa, December 2015-January 2016.

BMC Infect Dis 2018 Dec 29;18(1):709. Epub 2018 Dec 29.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa and the National Health Laboratory Service, Anzio Road, Observatory, Cape Town, 7925, South Africa.

Background: Human enteroviruses (HEVs) are common causal agents of aseptic meningitis in young children. Laboratory and syndromic surveillance during December 2015 and January 2016 noted an unusually high number of paediatric aseptic meningitis cases at a hospital in Mossel Bay, Western Cape Province, South Africa. HEV was detected in clinical samples, prompting an outbreak investigation. Read More

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http://dx.doi.org/10.1186/s12879-018-3641-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311073PMC
December 2018
2 Reads

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro.

Microb Pathog 2019 Mar 21;128:106-111. Epub 2018 Dec 21.

Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China. Electronic address:

As one of the major causative agents of hand, foot and mouth disease (HFMD), enterovirus 71 (EV71) is a small, non-enveloped positive stranded RNA virus. Children suffering EV71 infection may cause severe symptoms including neurological complications, pulmonary edema and aseptic meningitis. EV71 is a neurotropic virus and it can cause the damage of nervous cells, cytokine storm and toxic substance. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.12.032DOI Listing
March 2019
3 Reads

Haploidentical transplantation using low-dose alemtuzumab: Comparison with haploidentical transplantation using low-dose thymoglobulin.

Eur J Haematol 2019 Mar 9;102(3):256-264. Epub 2019 Jan 9.

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Objectives: To establish the optimal strategy for haploidentical hematopoietic stem cell transplantation (HSCT).

Methods: We performed a prospective study on haploidentical HSCT using low-dose alemtuzumab. Alemtuzumab was added at 0. Read More

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http://doi.wiley.com/10.1111/ejh.13204
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http://dx.doi.org/10.1111/ejh.13204DOI Listing
March 2019
16 Reads

Mollaret Meningitis with a High Level of Cytokines in the Cerebrospinal Fluid Successfully Treated by Indomethacin.

Intern Med 2019 Apr 18;58(8):1163-1166. Epub 2018 Dec 18.

Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Japan.

A rare case of Mollaret meningitis characterized by four recurrent episodes of aseptic meningitis during a three-year period is reported. The patient showed a high fever and severe headache accompanied by a high level of cerebrospinal fluid (CSF) cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). The symptoms and high CSF cytokines were resolved immediately after introducing indomethacin treatment. Read More

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http://dx.doi.org/10.2169/internalmedicine.1676-18DOI Listing

Rheumatoid meningitis: A rare cause of aseptic meningitis with frequently stroke-like episodes.

Neurol Clin Pract 2018 Oct;8(5):451-455

Department of Neurology (SS, HB, CG, GT, TM), Center for Internal Medicine (US), and Institute of Neuropathology (JM), University Hospital Hamburg-Eppendorf; and Klinik für Rheumatologie und Immunologie (CI-K), Klinikum Bad Bramstedt, Germany.

Background: Rheumatoid meningitis (RM) is a rare manifestation of rheumatoid arthritis (RA) and may present with stroke-like episodes. We describe diagnostic findings and the outcome in patients with RM.

Methods: We identified 6 patients with RM in different stages of RA mostly admitted with stroke-like episodes or common features of meningitis. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276349PMC
October 2018

Increased risk for aseptic meningitis after amoxicillin or amoxicillin-clavulanic acid in males: A signal revealed by subset disproportionality analysis within a global database of suspected adverse drug reactions.

Pharmacoepidemiol Drug Saf 2019 Mar 17;28(3):389-395. Epub 2018 Dec 17.

Research Section, Uppsala Monitoring Centre, Uppsala, Sweden.

Purpose: Drug-induced aseptic meningitis (DIAM) is an inflammation of the membranes of the central nervous system caused by certain medications. It is a rare clinical entity whose risk factors are not yet fully elucidated. A local pattern of disproportionality within a global database of suspected adverse drug reactions (ADRs) revealed an increased reporting of aseptic meningitis and amoxicillin-clavulanic acid (AC) in males. Read More

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http://dx.doi.org/10.1002/pds.4707DOI Listing
March 2019
1 Read

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2019 Feb 14;34(1):9-21. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

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http://link.springer.com/10.1007/s12250-018-0071-9
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http://dx.doi.org/10.1007/s12250-018-0071-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420560PMC
February 2019
11 Reads

Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis.

Neurol Clin Neurosci 2018 Nov 24;6(6):191-193. Epub 2018 Sep 24.

Department of Neurology Shin-yurigaoka General Hospital Kanagawa Japan.

We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Read More

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http://doi.wiley.com/10.1111/ncn3.12232
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http://dx.doi.org/10.1111/ncn3.12232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282518PMC
November 2018
24 Reads

Genetic diversity of the enteroviruses detected from cerebrospinal fluid (CSF) samples of patients with suspected aseptic meningitis in northern West Bank, Palestine in 2017.

PLoS One 2018 10;13(12):e0202243. Epub 2018 Dec 10.

Rafeedia Medical Laboratory Hospital, Palestinian Ministry of Health, Nablus, Palestine.

Background: Human enterovirus genus showed a wide range of genetic diversity.

Objectives: To investigate the genetic diversity of the enteroviruses isolated in 2017 in northern West Bank, Palestine.

Study Design: 249 CSF samples from aseptic meningitis cases were investigated for HEV using two RT-PCR protocols targeting the 5' NCR and the VP1 region of the HEV genome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202243PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287809PMC
December 2018
4 Reads
3.234 Impact Factor

Causal relationship between immunological responses and adverse reactions following vaccination.

Authors:
Tetsuo Nakayama

Vaccine 2019 Jan 30;37(2):366-371. Epub 2018 Nov 30.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, 5-9-1 Shirokane Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses. Vaccines stimulate the innate immunity of host immunological defense mechanisms and induce the development of specific acquired immunity. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.11.045DOI Listing
January 2019
3 Reads

Pearls & Oy-sters: Neuro-Sweet disease presenting as ischemic stroke and aseptic meningitis.

Neurology 2018 Dec;91(23):e2197-e2199

From the Department of Neurology (A.S.D., S.E.C., M.A.B., N.S.R., N.V.) and Department of Medicine, Division of Rheumatology (S.H.U.), Massachusetts General Hospital, and Department of Neurology, Brigham and Women's Hospital (A.S.D., S.E.C.), Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000006628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282232PMC
December 2018
2 Reads

A Rare Case of Levetiracetam and Drug-Induced Idiopathic Aseptic Meningitis in a Pediatric Patient.

Pharmacotherapy 2019 Jan 11;39(1):109-113. Epub 2018 Dec 11.

Hovnanian Children's Hospital at Hackensack Meridian Health, Hackensack, New Jersey.

Levetiracetam (LEV) is a pyrrolidine derivative antiepileptic medication used for the treatment of seizures in pediatric and adult patients. We report a case of probable LEV-induced aseptic meningitis in a 13-year-old girl. The patient received LEV for a generalized seizure disorder and presented with symptoms 5 days after medication initiation. Read More

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http://dx.doi.org/10.1002/phar.2198DOI Listing
January 2019
3 Reads

Combined testing for herpes simplex virus and Mycobacterium tuberculosis DNA in cerebrospinal fluid of patients with aseptic meningitis in Burkina Faso, West Africa.

J Clin Lab Anal 2019 Mar 25;33(3):e22719. Epub 2018 Nov 25.

UMR 1058, INSERM/EFS/Université de Montpellier, Montpellier, France.

Background: Little is known about the involvement of herpes simplex virus (HSV) or Mycobacterium tuberculosis (MTB) as potentially curable causes of central nervous system (CNS) infections in sub-Saharan Africa.

Objective: In this study, we developed a PCR assay dedicated to simultaneous testing of HSV1/HSV2 and MTB in Burkina Faso, a country where HSV is neglected as a cause of CNS infection and where TB prevalence is high.

Methods: A consensus HSV1/HSV2 set of primers and probe were designed and combined to primers and probe targeting the IS6110 repetitive insertion sequence of MTB. Read More

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http://dx.doi.org/10.1002/jcla.22719DOI Listing
March 2019
5 Reads

High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections.

J Neuroinflammation 2018 Nov 23;15(1):327. Epub 2018 Nov 23.

Department of Infectious Diseases, Oslo University Hospital, Ullevaal Hospital, P. O. Box 4956 Nydalen, N-0450, Oslo, Norway.

Background: The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces the activation of the kynurenine pathway (KP) with the production of neuroactive metabolites. Herein, we explored cytokine and KP responses in cerebrospinal fluid (CSF) and serum in patients with encephalitis, aseptic, and bacterial meningitis. Read More

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http://dx.doi.org/10.1186/s12974-018-1366-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260858PMC
November 2018
9 Reads

A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5.

Emerg Microbes Infect 2018 Nov 21;7(1):185. Epub 2018 Nov 21.

Institute for Biological Products Control, National Institutes for Food and Drug Control, Beijing, China.

As one of the key members of the coxsackievirus B group, coxsackievirus B5 (CV-B5) can cause many central nervous system diseases, such as viral encephalitis, aseptic meningitis, and acute flaccid paralysis. Notably, epidemiological data indicate that outbreaks of CV-B5-associated central nervous system (CNS) diseases have been reported worldwide throughout history. In this study, which was conducted to promote CV-B5 vaccine and anti-virus drug research, a 3-day-old BALB/c mouse model was established using a CV-B5 clinical isolate (CV-B5/JS417) as the challenge strain. Read More

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http://dx.doi.org/10.1038/s41426-018-0186-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246558PMC
November 2018
19 Reads

Incidence of Prolonged Systemic Steroid Treatment after Surgery for Acoustic Neuroma and Its Implications.

J Neurol Surg B Skull Base 2018 Dec 13;79(6):559-568. Epub 2018 Apr 13.

Department of Otolaryngology - Head and Neck Surgery, Weill Cornell Medical College, New York, United States.

 To determine the incidence of prolonged postoperative systemic corticosteroid therapy after surgery for acoustic neuroma as well as the indications and associated risk factors that could lead to prolonged steroid administration, and the incidence of steroid-related adverse effects.  Retrospective chart review.  Retrospective chart review of patients undergoing resection of acoustic neuroma between 2010 and 2017 at two tertiary care medical centers. Read More

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http://dx.doi.org/10.1055/s-0038-1641752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239872PMC
December 2018
13 Reads

Impact of Drinking Water Quality on the Development of Enteroviral Diseases in Korea.

Int J Environ Res Public Health 2018 11 14;15(11). Epub 2018 Nov 14.

Department of Social and Preventive Medicine, School of Medicine, Sungkyunkwan University, Suwon 440-746, Korea.

Enterovirus diseases are fecal-orally transmitted, and its transmission may be closely related with the drinking water quality and other environmental factors. This study aimed to assess the association between environmental factors including drinking water quality and the incidence of enteroviral diseases in metropolitan provinces of Korea. Using monthly number of hand-foot-mouth disease (HFMD), aseptic meningitis (AM) and acute hemorrhage conjunctivitis (AHC) cases, generalized linear Poisson model was applied to estimate the effects of environmental factors on the monthly cases. Read More

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http://www.mdpi.com/1660-4601/15/11/2551
Publisher Site
http://dx.doi.org/10.3390/ijerph15112551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266091PMC
November 2018
13 Reads

Recurrent Amoxicillin-Induced Aseptic Meningitis.

Can J Neurol Sci 2018 11;45(6):701-702

Department of Medicine (Neurology),Memorial University of Newfoundland,St. John's,Newfoundland and Labrador, Canada.

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http://dx.doi.org/10.1017/cjn.2018.348DOI Listing
November 2018
1 Read

Sero-molecular epidemiology of enterovirus-associated encephalitis in Zhejiang Province, China, from 2014 to 2017.

Int J Infect Dis 2019 Feb 10;79:58-64. Epub 2018 Nov 10.

Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang, People's Republic of China.

Background: Recently, both sporadic and outbreak aseptic meningitis caused by enteroviruses have been reported in Zhejiang Province based on a surveillance system.

Methods: This study analysed the epidemiologic features, phylogenetic characteristics and prevalence of enterovirus neutralizing antibodies (nAbs) from 2014 to 2017 in Zhejiang Province.

Results: A total of 584 samples were collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183458
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http://dx.doi.org/10.1016/j.ijid.2018.11.002DOI Listing
February 2019
18 Reads

Adenovirus-Associated Central Nervous System Disease in Children.

J Pediatr 2019 Feb 6;205:130-137. Epub 2018 Nov 6.

Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Objective: To characterize the spectrum and salient clinical features of adenovirus-associated neurologic disease in immunocompetent children.

Study Design: Previously healthy children (aged 1 month-18 years) with central nervous system (CNS) disease associated with adenovirus infection were identified via the Encephalitis Registry (1996-2016) and Microbiology Database (2000-2016) at The Hospital for Sick Children, Toronto, and by systematic review of the literature. The data were pooled and analyzed to identify the spectrum of illness, clinical outcome, and risk factors for death or neurologic impairment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183136
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http://dx.doi.org/10.1016/j.jpeds.2018.09.036DOI Listing
February 2019
26 Reads

Effects of a Public Subsidy Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan.

Jpn J Infect Dis 2019 Mar 31;72(2):106-111. Epub 2018 Oct 31.

Department of Public Health, Osaka City University Graduate School of Medicine.

Nagoya City initiated a public subsidy program for mumps vaccination using either the Torii or Hoshino strains in August 2010. To determine the effects of the program, we used publicly available information from Nagoya City to investigate the changes in immunization rates and numbers of patients who developed post-immunization adverse reactions, including post-vaccinal aseptic meningitis, in the 7 years since its initiation. We also investigated the numbers of mumps patients reported by sentinel sites in a national database during this period. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2018.276DOI Listing
March 2019
7 Reads

Neurological presentations of Bartonella henselae infection.

Neurol Sci 2019 Feb 27;40(2):261-268. Epub 2018 Oct 27.

Neurology Department, Complejo Hospitalario Universitario Pontevedra, Loureiro Crespo, 2, 36002, Pontevedra, Spain.

Objective: Neurological symptoms in patients with cat-scratch disease (CSD) have been rarely reported. The aim of this study is to analyze the frequency of neurological CSD (NCSD) and describe the disease clinical presentation, management and outcome.

Material And Methods: We retrospectively selected patients with a CSD syndrome and Bartonella IgG titers > 1:256. Read More

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http://link.springer.com/10.1007/s10072-018-3618-5
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http://dx.doi.org/10.1007/s10072-018-3618-5DOI Listing
February 2019
12 Reads