3,847 results match your criteria Aseptic Meningitis


Increased risk for aseptic meningitis after amoxicillin or amoxicillin-clavulanic acid in males: A signal revealed by subset disproportionality analysis within a global database of suspected adverse drug reactions.

Pharmacoepidemiol Drug Saf 2018 Dec 17. Epub 2018 Dec 17.

Research Section, Uppsala Monitoring Centre, Uppsala, Sweden.

Purpose: Drug-induced aseptic meningitis (DIAM) is an inflammation of the membranes of the central nervous system caused by certain medications. It is a rare clinical entity whose risk factors are not yet fully elucidated. A local pattern of disproportionality within a global database of suspected adverse drug reactions (ADRs) revealed an increased reporting of aseptic meningitis and amoxicillin-clavulanic acid (AC) in males. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pds.4707DOI Listing
December 2018

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12250-018-0071-9
Publisher Site
http://dx.doi.org/10.1007/s12250-018-0071-9DOI Listing
December 2018
1 Read

Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis.

Neurol Clin Neurosci 2018 Nov 24;6(6):191-193. Epub 2018 Sep 24.

Department of Neurology Shin-yurigaoka General Hospital Kanagawa Japan.

We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ncn3.12232
Publisher Site
http://dx.doi.org/10.1111/ncn3.12232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282518PMC
November 2018
1 Read

Genetic diversity of the enteroviruses detected from cerebrospinal fluid (CSF) samples of patients with suspected aseptic meningitis in northern West Bank, Palestine in 2017.

PLoS One 2018 10;13(12):e0202243. Epub 2018 Dec 10.

Rafeedia Medical Laboratory Hospital, Palestinian Ministry of Health, Nablus, Palestine.

Background: Human enterovirus genus showed a wide range of genetic diversity.

Objectives: To investigate the genetic diversity of the enteroviruses isolated in 2017 in northern West Bank, Palestine.

Study Design: 249 CSF samples from aseptic meningitis cases were investigated for HEV using two RT-PCR protocols targeting the 5' NCR and the VP1 region of the HEV genome. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202243PLOS
December 2018

Causal relationship between immunological responses and adverse reactions following vaccination.

Authors:
Tetsuo Nakayama

Vaccine 2018 Nov 29. Epub 2018 Nov 29.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, 5-9-1 Shirokane Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses. Vaccines stimulate the innate immunity of host immunological defense mechanisms and induce the development of specific acquired immunity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2018.11.045DOI Listing
November 2018
1 Read

Pearls & Oy-sters: Neuro-Sweet disease presenting as ischemic stroke and aseptic meningitis.

Neurology 2018 Dec;91(23):e2197-e2199

From the Department of Neurology (A.S.D., S.E.C., M.A.B., N.S.R., N.V.) and Department of Medicine, Division of Rheumatology (S.H.U.), Massachusetts General Hospital, and Department of Neurology, Brigham and Women's Hospital (A.S.D., S.E.C.), Harvard Medical School, Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006628DOI Listing
December 2018
1 Read

A Rare Case of Levetiracetam and Drug-Induced Idiopathic Aseptic Meningitis in a Pediatric Patient.

Pharmacotherapy 2018 Nov 29. Epub 2018 Nov 29.

Hovnanian Children's Hospital at Hackensack Meridian Health, Hackensack, New Jersey.

Levetiracetam (LEV) is a pyrrolidine derivative antiepileptic medication used for the treatment of seizures in pediatric and adult patients. We report a case of probable LEV-induced aseptic meningitis in a 13-year-old girl. The patient received LEV for a generalized seizure disorder and presented with symptoms 5 days after medication initiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.2198DOI Listing
November 2018
1 Read

Combined testing for herpes simplex virus and Mycobacterium tuberculosis DNA in cerebrospinal fluid of patients with aseptic meningitis in Burkina Faso, West Africa.

J Clin Lab Anal 2018 Nov 25:e22719. Epub 2018 Nov 25.

UMR 1058, INSERM/EFS/Université de Montpellier, Montpellier, France.

Background: Little is known about the involvement of herpes simplex virus (HSV) or Mycobacterium tuberculosis (MTB) as potentially curable causes of central nervous system (CNS) infections in sub-Saharan Africa.

Objective: In this study, we developed a PCR assay dedicated to simultaneous testing of HSV1/HSV2 and MTB in Burkina Faso, a country where HSV is neglected as a cause of CNS infection and where TB prevalence is high.

Methods: A consensus HSV1/HSV2 set of primers and probe were designed and combined to primers and probe targeting the IS6110 repetitive insertion sequence of MTB. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcla.22719DOI Listing
November 2018
1 Read

High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections.

J Neuroinflammation 2018 Nov 23;15(1):327. Epub 2018 Nov 23.

Department of Infectious Diseases, Oslo University Hospital, Ullevaal Hospital, P. O. Box 4956 Nydalen, N-0450, Oslo, Norway.

Background: The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces the activation of the kynurenine pathway (KP) with the production of neuroactive metabolites. Herein, we explored cytokine and KP responses in cerebrospinal fluid (CSF) and serum in patients with encephalitis, aseptic, and bacterial meningitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-018-1366-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260858PMC
November 2018
3 Reads

A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5.

Emerg Microbes Infect 2018 Nov 21;7(1):185. Epub 2018 Nov 21.

Institute for Biological Products Control, National Institutes for Food and Drug Control, Beijing, China.

As one of the key members of the coxsackievirus B group, coxsackievirus B5 (CV-B5) can cause many central nervous system diseases, such as viral encephalitis, aseptic meningitis, and acute flaccid paralysis. Notably, epidemiological data indicate that outbreaks of CV-B5-associated central nervous system (CNS) diseases have been reported worldwide throughout history. In this study, which was conducted to promote CV-B5 vaccine and anti-virus drug research, a 3-day-old BALB/c mouse model was established using a CV-B5 clinical isolate (CV-B5/JS417) as the challenge strain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41426-018-0186-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246558PMC
November 2018
4 Reads

Incidence of Prolonged Systemic Steroid Treatment after Surgery for Acoustic Neuroma and Its Implications.

J Neurol Surg B Skull Base 2018 Dec 13;79(6):559-568. Epub 2018 Apr 13.

Department of Otolaryngology - Head and Neck Surgery, Weill Cornell Medical College, New York, United States.

 To determine the incidence of prolonged postoperative systemic corticosteroid therapy after surgery for acoustic neuroma as well as the indications and associated risk factors that could lead to prolonged steroid administration, and the incidence of steroid-related adverse effects.  Retrospective chart review.  Retrospective chart review of patients undergoing resection of acoustic neuroma between 2010 and 2017 at two tertiary care medical centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1641752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239872PMC
December 2018
3 Reads

Impact of Drinking Water Quality on the Development of Enteroviral Diseases in Korea.

Int J Environ Res Public Health 2018 Nov 14;15(11). Epub 2018 Nov 14.

Department of Social and Preventive Medicine, School of Medicine, Sungkyunkwan University, Suwon 440-746, Korea.

Enterovirus diseases are fecal-orally transmitted, and its transmission may be closely related with the drinking water quality and other environmental factors. This study aimed to assess the association between environmental factors including drinking water quality and the incidence of enteroviral diseases in metropolitan provinces of Korea. Using monthly number of hand-foot-mouth disease (HFMD), aseptic meningitis (AM) and acute hemorrhage conjunctivitis (AHC) cases, generalized linear Poisson model was applied to estimate the effects of environmental factors on the monthly cases. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/1660-4601/15/11/2551
Publisher Site
http://dx.doi.org/10.3390/ijerph15112551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266091PMC
November 2018
9 Reads

Recurrent Amoxicillin-Induced Aseptic Meningitis.

Can J Neurol Sci 2018 Nov;45(6):701-702

Department of Medicine (Neurology),Memorial University of Newfoundland,St. John's,Newfoundland and Labrador, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/cjn.2018.348DOI Listing
November 2018

Sero-molecular epidemiology of enterovirus-associated encephalitis in Zhejiang Province, China, from 2014 to 2017.

Int J Infect Dis 2018 Nov 10;79:58-64. Epub 2018 Nov 10.

Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang, People's Republic of China.

Background: Recently, both sporadic and outbreak aseptic meningitis caused by enteroviruses have been reported in Zhejiang Province based on a surveillance system.

Methods: This study analysed the epidemiologic features, phylogenetic characteristics and prevalence of enterovirus neutralizing antibodies (nAbs) from 2014 to 2017 in Zhejiang Province.

Results: A total of 584 samples were collected. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S12019712183458
Publisher Site
http://dx.doi.org/10.1016/j.ijid.2018.11.002DOI Listing
November 2018
9 Reads

Adenovirus-Associated Central Nervous System Disease in Children.

J Pediatr 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Objective: To characterize the spectrum and salient clinical features of adenovirus-associated neurologic disease in immunocompetent children.

Study Design: Previously healthy children (aged 1 month-18 years) with central nervous system (CNS) disease associated with adenovirus infection were identified via the Encephalitis Registry (1996-2016) and Microbiology Database (2000-2016) at The Hospital for Sick Children, Toronto, and by systematic review of the literature. The data were pooled and analyzed to identify the spectrum of illness, clinical outcome, and risk factors for death or neurologic impairment. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223476183136
Publisher Site
http://dx.doi.org/10.1016/j.jpeds.2018.09.036DOI Listing
November 2018
7 Reads

Effects of a Public Subsidization Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan.

Jpn J Infect Dis 2018 Oct 31. Epub 2018 Oct 31.

Department of Public Health, Osaka City University Graduate School of Medicine.

Nagoya City initiated a public subsidization program for mumps vaccination using either Torii- or Hoshino-strains in August 2010. To demonstrate the effects of the program, we used publicly available information from Nagoya City to investigate the changes in immunization rate and numbers of patients who developed post-immunization adverse reactions, including post-vaccinal aseptic meningitis, in the 7 years since its initiation. We also investigated the numbers of mumps patients reported during this period by sentinel sites in a national database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7883/yoken.JJID.2018.276DOI Listing
October 2018
1 Read

Neurological presentations of Bartonella henselae infection.

Neurol Sci 2018 Oct 27. Epub 2018 Oct 27.

Neurology Department, Complejo Hospitalario Universitario Pontevedra, Loureiro Crespo, 2, 36002, Pontevedra, Spain.

Objective: Neurological symptoms in patients with cat-scratch disease (CSD) have been rarely reported. The aim of this study is to analyze the frequency of neurological CSD (NCSD) and describe the disease clinical presentation, management and outcome.

Material And Methods: We retrospectively selected patients with a CSD syndrome and Bartonella IgG titers > 1:256. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10072-018-3618-5
Publisher Site
http://dx.doi.org/10.1007/s10072-018-3618-5DOI Listing
October 2018
5 Reads

Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease.

Front Microbiol 2018 8;9:2422. Epub 2018 Oct 8.

Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.

Enterovirus (EV) infections are a major threat to global public health, and are responsible for mild respiratory illness, hand, foot, and mouth disease (HFMD), acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis epidemic. Among them, HFMD is a common pediatric infectious disease caused by EVs of the family including EV-A71, coxsackieviruses (CV)-A2, CV-A6, CV-A10, and CV-A16. Due to lack of vaccines and specific antiviral therapeutics, millions of children still suffer from HFMD. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fmicb.2018.02422
Publisher Site
http://dx.doi.org/10.3389/fmicb.2018.02422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186807PMC
October 2018
9 Reads

Elsberg syndrome related to varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes mellitus.

Ther Clin Risk Manag 2018 9;14:1951-1954. Epub 2018 Oct 9.

Division of Diabetes and Metabolic Diseases, Nihon University School of Medicine, Tokyo, Japan,

Patients with diabetes mellitus (DM) are at increased risk of infections, with the urinary tract being the most frequent infection site. Incomplete bladder emptying, frequent urination and abdominal distension are typical symptoms of urinary tract infections (UTIs). A 68-year-old female with a long history of poorly controlled type 2 DM (T2DM) visited our hospital complaining of urinary retention, which was initially diagnosed as cystitis by another doctor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/TCRM.S178782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186309PMC
October 2018
1 Read

Early canakinumab therapy for the sensorineural deafness in a family with Muckle-Wells syndrome due to a novel mutation of NLRP3 gene.

Clin Rheumatol 2018 Oct 18. Epub 2018 Oct 18.

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Cryopyrin-associated periodic syndrome (CAPS) is one of the autoinflammatory disorders caused by mutations in NLRP3 gene. The over-production of interleukin (IL)-1β induced by NLRP3 gene mutations plays an important role in the pathophysiology of CAPS. We diagnosed 3 patients with CAPS, who were lineal family members having a novel mutation of NLRP3 gene. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10067-018-4331-8
Publisher Site
http://dx.doi.org/10.1007/s10067-018-4331-8DOI Listing
October 2018
6 Reads
1.770 Impact Factor

Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations.

Mult Scler Relat Disord 2018 Oct 3;27:30-33. Epub 2018 Oct 3.

UT Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, Texas, TX 75235, United States.

Objective: To describe 2 atypical cases with Anti-MOG antibody related demyelinating syndrome.

Methodology: Case series.

Results: We present two cases. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22110348183036
Publisher Site
http://dx.doi.org/10.1016/j.msard.2018.10.003DOI Listing
October 2018
2 Reads

A Teenage Girl With Aseptic Meningitis and Abdominal Pain.

Pediatr Infect Dis J 2018 Oct 5. Epub 2018 Oct 5.

Division of Infectious Diseases, Children's Hospital of Michigan, Detroit, MI, USA.

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00006454-900000000-9651
Publisher Site
http://dx.doi.org/10.1097/INF.0000000000002213DOI Listing
October 2018
2 Reads

Rapidly progressive encephalopathy caused by Coxsackie meningoencephalitis in an elderly male.

J Neurovirol 2018 Dec 5;24(6):780-785. Epub 2018 Oct 5.

Department of Neurology, Division of Neurocritical Care and Program in Trauma, University of Maryland Medical Center, Baltimore, MD, USA.

Enteroviruses and Coxsackie viruses are common causes of aseptic meningitis and encephalitis in children. These infections usually have a benign, self-limited course. However, they can have a florid presentation in immunocompromised patients, such as neonates, patients exposed to immunosuppressive drugs, such as transplant recipients and patients with agammaglobulinemia. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s13365-018-0676-7
Publisher Site
http://dx.doi.org/10.1007/s13365-018-0676-7DOI Listing
December 2018
7 Reads

Subdural Hematoma as a Consequence of Labor Epidural Analgesia.

Asian J Neurosurg 2018 Jul-Sep;13(3):931-934

Department of Radiology, Sacred Heart of Jesus Hospital, Benevento, Italy.

Subdural hematoma (SDH) following labor epidural analgesia is a rare neurological complication. SDH is a late complication of this procedure; it is caused by a leak of cerebrospinal fluid that may damage the vascular structures of the brain. Persistent headache in the days after labor epidural analgesia is a nonspecific clinical symptom caused by hematoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ajns.AJNS_115_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159069PMC
October 2018
1 Read

Epstein-barr virus-associated encephalitis in a case-series of more than 40 patients.

Wiad Lek 2018 ;71(6):1224-1230

Sumy State University, Sumy, Ukraine.

Objective: Introduction: Epstein-Barr virus (EBV) infection can present with neurologic manifestations including encephalitis, aseptic meningitis, Guillain-Barre syndrome, and many others. Most reported cases have been in children. Little is known about EBV encephalitis in adults. Read More

View Article

Download full-text PDF

Source
January 2018
10 Reads

Recurrent aseptic meningitis with mutations: a novel pathogenesis of recurrent meningitis successfully treated by eculizumab.

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Neurology, Kobe City Medical Center General Hospital, Kobe, Japan.

We report the case of a patient with mutations who experienced recurrent aseptic meningitis 121 times over 16 years before developing paroxysmal nocturnal haemoglobinuria (PNH). Each episode was preceded by urticaria and arthralgia. After developing PNH, haemolysis occurred prior to meningitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-225910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169622PMC
September 2018
1 Read

Hemorrhagic Stroke and Cerebral Venous Thrombosis: Rare Neurological Sequelae of Chickenpox Infection.

Ann Indian Acad Neurol 2018 Jul-Sep;21(3):228-232

Department of Medicine, VMMC and Safdarjung Hospital, New Delhi, India.

Chickenpox (varicella) is primarily a disease of childhood which occurs due to infection with varicella-zoster virus (VZV). Primary VZV infection is rare in adults due to exposure in early childhood in our country. In adults, it is associated with some serious systemic and neurological complications which can follow both primary infection and reactivation of VZV. Read More

View Article

Download full-text PDF

Source
http://www.annalsofian.org/text.asp?2018/21/3/228/240428
Publisher Site
http://dx.doi.org/10.4103/aian.AIAN_421_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137630PMC
September 2018
13 Reads

Neurological complications of immune checkpoint inhibitors: what happens when you 'take the brakes off' the immune system.

Ther Adv Neurol Disord 2018 14;11:1756286418799864. Epub 2018 Sep 14.

Chief Neuromuscular Division, Thomas Jefferson University, Philadelphia, PA Chief, Neuroimmunology Unit, Department of Pathophysiology, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Patients with advanced malignancies treated with immune checkpoint inhibitors are at increased risk for developing immune-related neurological complications. It is a phenomenon of immunological twist when immunotherapy against co-stimulatory molecules activates previously normal T cells to kill tumor cells but, in so doing, the T cells become unrestrained, triggering other autoimmune diseases for which conventional immunotherapy is needed. The most common autoimmune neurological diseases, usually occurring within 2-12 weeks after immune checkpoint inhibitor initiation, include: inflammatory myopathies, myasthenia gravis, acute and chronic demyelinating polyradiculoneuropathies, vasculitic neuropathies, isolated cranial neuropathies, aseptic meningitis, autoimmune encephalitis, multiple sclerosis and hypophysitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1756286418799864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144585PMC
September 2018
7 Reads

Treatment of a symptomatic cervical perineural cyst with ultrasound-guided cervical selective nerve root block: A case report.

Medicine (Baltimore) 2018 Sep;97(37):e12412

Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.

Rationale: Symptomatic cervical perineural cysts are extremely rare, and they cause radicular pain by compressing the cervical nerve root. Several methods have been applied to manage the radicular pain induced by cervical perineural cysts, including medication, percutaneous procedures, and surgery. However, these methods are associated with various outcomes and complications. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00005792-201809140-0009
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000012412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156009PMC
September 2018
35 Reads

ISMP Adverse Drug Reactions: Adalimumab-Induced Aseptic Meningitis Pill Desiccant -Induced Acute Hypoxic Respiratory Failure Rivastigmine Patch -Induced Angioedema Acute Liver Failure Due to Etodolac Severe Cognitive Impairment Due to High Free Valproic Acid Levels.

Hosp Pharm 2018 Oct 18;53(5):292-295. Epub 2018 Aug 18.

Temple University School of Pharmacy, Philadelphia, PA, USA.

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of revention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-ßDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with ur readers. E-mail Dr. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0018578718794518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130117PMC
October 2018
7 Reads

Utility of Clinical and Laboratory Decision Rules in Identifying Bacterial Meningitis Among Children With suspicion of Central Nervous System Infections in a Malaria-Endemic Area, Mbarara Uganda.

Pediatr Infect Dis J 2018 Sep 7. Epub 2018 Sep 7.

Several decision rules combining clinical and biological parameters have been proposed to distinguish bacterial from aseptic meningitis, but have not been evaluated in Africa. In children hospitalized with suspected central nervous system infections in Uganda, we found that the Bacterial Meningitis Score and Meningitest showed lower performance than in European children, and that a decision rule designed specifically using parameters associated with bacterial meningitis also showed inadequate diagnostic performance for clinical use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/INF.0000000000002185DOI Listing
September 2018
6 Reads

Calculated decisions: Rule of 7s for Lyme meningitis

Authors:
Matthew Lecuyer

Pediatr Emerg Med Pract 2018 09 1;15(Suppl 9):CD1-2. Epub 2018 Sep 1.

Department of Emergency Medicine (Pediatrics), Warren Alpert Medical School of Brown University, Providence, RI

The Rule of 7s for Lyme Meningitis is a validated clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis. Read More

View Article

Download full-text PDF

Source
September 2018
1 Read

Does This Adult Patient With Jolt Accentuation of Headache Have Acute Meningitis?

Headache 2018 Nov 4;58(10):1503-1510. Epub 2018 Sep 4.

Department of Neurology, Nitobe-Memorial Nakano General Hospital, Tokyo, Japan.

Objective: In order to identify appropriate candidates with suspected meningitis for lumbar puncture (LP), study designs and diagnostic values of jolt accentuation of headache (JA) were reviewed.

Background: Acute meningitis is a life-threatening disease that requires LP for accurate diagnosis. JA was reported the most sensitive indicator of cerebrospinal fluid pleocytosis; however, subsequent studies have failed to confirm this claim. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/head.13376
Publisher Site
http://dx.doi.org/10.1111/head.13376DOI Listing
November 2018
12 Reads

[Anti-NMDA receptor antibody-positive meningoencephalitis with SIADH and CNS demyelination: A case report].

Rinsho Shinkeigaku 2018 Sep 31;58(9):560-564. Epub 2018 Aug 31.

Department of Neurology, International University of Health and Welfare Hospital.

After a 34-year-old female developed a headache and high fever, she was diagnosed with aseptic meningitis. On admission, neurological examinations revealed cerebellar limb ataxia, horizontal gaze paretic nystagmus, and pyramidal tract signs. Laboratory tests showed hyponatremia (129 mEq/l). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5692/clinicalneurol.cn-001178DOI Listing
September 2018
7 Reads

Cryopyrin-Associated Periodic Fever Syndrome and the Nervous System.

Curr Treat Options Neurol 2018 Sep 3;20(10):43. Epub 2018 Sep 3.

Institute of Neurology, UCL, London, UK.

Purpose Of Review: The purpose of this review is to highlight the molecular and clinical characteristics of the cryopyrin-associated periodic fever syndrome (CAPS) and its management. CAPS is an autosomal dominantly inherited autoinflammatory disorder associated with mutations in the NLRP3 gene, which ultimately lead to excessive production of interleukin-1β (IL-1β) and systemic inflammation. Typical systemic features include fever, urticarial rash and arthralgia, and ultimately amyloidosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11940-018-0526-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132776PMC
September 2018
3 Reads

Molecular characterization of Coxsackievirus A16 strains isolated from children with severe hand, foot, and mouth disease in Yunnan, Southwest China, during 2009-2015.

J Med Virol 2019 Jan 9;91(1):155-160. Epub 2018 Oct 9.

The Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, China.

Coxsackievirus A16 (CV-A16) commonly causes mild symptoms, but severe diseases, such as aseptic meningitis, encephalitis, and even fatal cases, have been reported. Thirteen CV-A16 strains were isolated from patients with severe hand, foot, and mouth disease in Yunnan, Southwest China, from 2009 to 2015. Subgenotype B1a and B1b of CV-A16 were predominantly circulating the region with B1b the predominant strain in recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.25297DOI Listing
January 2019
7 Reads

Varicella Zoster aseptic meningitis: Report of an atypical case in an immunocompetent patient treated with oral valacyclovir.

IDCases 2018 25;13:e00446. Epub 2018 Aug 25.

Marshall University, MU Internal Medicine Residency Program, 1249 15th Street, Huntington, WV 25701, United States.

Varicella Zoster when described has the typical presentation of a dermatomal distribution of a rash and can further lead to CNS complications. This can be treated accordingly with the proper protocol, but if the presentation is atypical and the protocol is challenged or changed per specific patient outcomes, new developments can occur. Here we present a case of a 29-year-old Caucasian female that presented to the emergency department with headache, photophobia, and chills for 5 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idcr.2018.e00446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115539PMC
August 2018
1 Read

Acute aseptic meningitis during isotretinoin treatment for nodular acne solely presenting with headache: case report and brief review of the literature.

Int J Neurosci 2018 Oct 31:1-3. Epub 2018 Oct 31.

c Department of Neurology , "Saint Andrew's" State General Hospital of Patras , Patras , Greece.

Purpose/aim: We describe, in detail, the first case of isotretinoin-induced aseptic meningitis. A brief summary of the literature on drug-induced aseptic meningitis (DIAM) is also presented.

Materials And Methods: A 20-year old female patient with probable (Naranjo adverse reaction probability score of 7) DIAM during treatment with isotretinoin therapy for nodular acne solely, presenting with headache. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/00207454.2018.1
Publisher Site
http://dx.doi.org/10.1080/00207454.2018.1517763DOI Listing
October 2018
15 Reads

Nonsuppurative (Aseptic) Meningoencephalomyelitis Associated with Neurovirulent Astrovirus Infections in Humans and Animals.

Clin Microbiol Rev 2018 Oct 29;31(4). Epub 2018 Aug 29.

Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary.

SUMMARYAstroviruses are thought to be enteric pathogens. Since 2010, a certain group of astroviruses has increasingly been recognized, using up-to-date random amplification and high-throughput next-generation sequencing (NGS) methods, as potential neurovirulent (Ni) pathogens of severe central nervous system (CNS) infections, causing encephalitis, meningoencephalitis, and meningoencephalomyelitis. To date, neurovirulent astrovirus cases or epidemics have been reported for humans and domesticated mammals, including mink, bovines, ovines, and swine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/CMR.00040-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148189PMC
October 2018

Aseptic meningitis as a manifestation of a mitochondrial disorder.

Arch Med Sci 2018 Aug 29;14(5):1180-1183. Epub 2016 Dec 29.

Diagnostic Center, Meidling, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/aoms.2016.64850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111370PMC
August 2018
1 Read

[Sandfly fever-a "neglected" disease].

Hautarzt 2018 Nov;69(11):928-937

Fachbereich Tropenmedizin des Bundeswehrkrankenhauses Hamburg am Bernhard-Nocht Institut, Bernhard-Nocht Str. 74, 20359, Hamburg, Deutschland.

A 45-year-old woman presented at the outpatient department of a center for tropical diseases with fever, diarrhea, headache, myalgia, malaise, and an itchy papular rash. She had been on holiday with her family for 11 days in a mountain village in northern Cyprus. The place was infested with a lot of small, stinging flies or mosquitoes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00105-018-4251-1DOI Listing
November 2018

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration.

Nat Neurosci 2018 Sep 27;21(9):1209-1217. Epub 2018 Aug 27.

Center for Systems Biology, Department of Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Innate immune cells recruited to inflammatory sites have short life spans and originate from the marrow, which is distributed throughout the long and flat bones. While bone marrow production and release of leukocyte increases after stroke, it is currently unknown whether its activity rises homogeneously throughout the entire hematopoietic system. To address this question, we employed spectrally resolved in vivo cell labeling in the murine skull and tibia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41593-018-0213-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148759PMC
September 2018
20 Reads
16.095 Impact Factor

The value of serum procalcitonin in acute meningitis in children.

J Clin Neurosci 2018 Oct 22;56:28-33. Epub 2018 Aug 22.

Department of Clinical Pathology, Faculty of Medicine, Benha University, Egypt.

Early diagnosis and initial therapy are important to reduce the complications of bacterial meningitis. We aimed to evaluate the diagnostic value of serum procalcitonin in children with acute meningitis. We included 40 children (4 months-14 years) suspected to have acute meningitis in our study. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09675868173210
Publisher Site
http://dx.doi.org/10.1016/j.jocn.2018.08.012DOI Listing
October 2018
18 Reads

Coxsackievirus B5 Aseptic Meningitis in Infants in Chiba Prefecture, Japan, in 2016.

J Nippon Med Sch 2018 ;85(3):187-190

Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital.

Background: Infantile aseptic meningitis is a rare infection of the central nervous system. Coxsackievirus B5 (CVB5) is an enterovirus that is sometimes associated with aseptic meningitis and encephalitis.

Case Presentation: We report on three isolated infants with aseptic meningitis caused by CVB5 in the spring and summer of 2016 with nearly identical 404-bp CVB5 Viral Capsid Protein 1 (VP1) sequences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1272/jnms.JNMS.2018_85-28DOI Listing
October 2018
12 Reads

Leucine-rich alpha-2 glycoprotein in the cerebrospinal fluid is a potential inflammatory biomarker for meningitis.

J Neurol Sci 2018 Sep 10;392:51-55. Epub 2018 Jul 10.

Department of Pediatric Neurology, Fukuoka Children's Hospital, Fukuoka, Japan. Electronic address:

Background: Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for inflammatory diseases. We evaluated the levels of LRG, interleukin (IL)-6, and tumor necrosis factor (TNF)-α in the cerebrospinal fluid (CSF) of children with meningitis.

Methods: CSF samples from 10 patients with bacterial meningitis (BM) and 10 with aseptic meningitis (AM) were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2018.07.006DOI Listing
September 2018

Factors associated with severe neurologic complications in patients with either hand-foot-mouth disease or herpangina: A nationwide observational study in South Korea, 2009-2014.

PLoS One 2018 10;13(8):e0201726. Epub 2018 Aug 10.

Department of Pediatrics, Hanyang University College of Medicine, Seoul, South Korea.

Background: In 2009, a nationwide sentinel surveillance for hand-foot-mouth disease (HFMD) and herpangina (HA) with neurologic complications was initiated in South Korea. We used this surveillance system to investigate the clinical characteristics of patients with either HFMD or HA with neurologic complications, with the aim of determining risk factors for severe neurologic complications.

Methods: A retrospective review of medical records was conducted on all cases of HFMD and HA with neurologic complications that were reported in the national system between April 1, 2009 and December 31, 2014. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201726PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086402PMC
August 2018
8 Reads

Probable dysimmune epilepsia partialis continua manifesting as epileptic moving toes syndrome: electroclinical features of a challenging case.

Epileptic Disord 2018 Aug;20(4):301-312

Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg Austria, Centre for Cognitive Neuroscience Salzburg, Austria, Department of Public Health Technology Assessment, UMIT - University for Health Sciences, Medical Informatics and Technology, Hall.i.T., Austria.

Epilepsia partialis continua (EPC) is a rare form of focal status epilepticus. We describe a 22-year-old woman with EPC manifesting with isolated toe movements, prevalent over the left side and initially misdiagnosed as psychogenic, clinically almost indistinguishable from those observed in "painful legs and moving toes syndrome". The continuous involuntary movements with EMG correlates of twitches lasting <100 ms, the sharp waves over fronto-central regions on EEG, and the marked asymmetry in somatosensory evoked potentials with higher cortical amplitude over the right side following peripheral stimulation over the left foot confirmed the epileptic nature of the symptoms, leading to the diagnosis of EPC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2018.0983DOI Listing
August 2018
20 Reads

An unusual case of inflammatory meningitis in a young man with systemic lupus erythematosus.

Lupus 2018 Oct 9;27(11):1864-1866. Epub 2018 Aug 9.

1 Department of Rheumatology, Royal Hallamshire Hospital, Sheffield, UK.

We describe a man presenting with unusual neurological manifestations of systemic lupus erythematosus (SLE) including pachymeningitis, aseptic meningitis and encephalitis with grossly elevated cerebrospinal fluid protein, responding to immunosuppression. Initially he had intermittent dysarthria, dysphasia and unilateral upper limb weakness. One month later he experienced dysphasia, right-sided hemiparesis and confusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203318791760DOI Listing
October 2018
2 Reads

Effect of Staphylococcal Decolonization Regimen and Change in Antibiotic Prophylaxis Regimen on Incidence of Postcraniotomy Aseptic Meningitis.

World Neurosurg 2018 Nov 1;119:e534-e540. Epub 2018 Aug 1.

Department of Neurological Sciences, Christian Medical College, Vellore, Tamilnadu, India. Electronic address:

Objective: To study the effect of a staphylococcal decolonization regimen (SDR) and change in antibiotic prophylaxis regimen on postoperative meningitis (bacterial and aseptic) rates in patients undergoing elective cranial surgery.

Methods: Data on elective craniotomy (supratentorial and infratentorial) were collected retrospectively for a total of 4 years-2 years before (2011-2012; group A) and 2 years after (2014-2015; group B) initiation of a SDR and a change in the antibiotic prophylaxis regimen (from chloramphenicol to ceftriaxone) in a neurosurgical unit of a tertiary care hospital. The SDR consisted of a 4% chlorhexidine scrub bath once a day and 10% betadine ointment application intranasally twice daily for ≥2 days before surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.07.200DOI Listing
November 2018
9 Reads
2.420 Impact Factor

The combination of cerebrospinal fluid procalcitonin, lactate, interleukin-8 and interleukin-10 concentrations for the diagnosis of postneurosurgical bacterial meningitis: A prospective study.

Ann Clin Biochem 2018 Aug 27:4563218794729. Epub 2018 Aug 27.

3 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Background The differential diagnosis between postneurosurgical bacterial meningitis and aseptic meningitis remains challenging both for the clinician and the laboratory. Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. Methods This prospective cohort study included patients with suspected bacterial meningitis after neurosurgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0004563218794729DOI Listing
August 2018
11 Reads