4,364 results match your criteria Aseptic Meningitis

Aseptic Meningitis and Its Viral Etiologies, Clinical Characteristics and Management Practices in Children: A Retrospective Hospital-Based Study From Jordan.

Cureus 2022 Apr 22;14(4):e24383. Epub 2022 Apr 22.

Pediatrics, The University of Jordan, Amman, JOR.

Purpose In this study, we aimed to describe the clinical characteristics, laboratory findings, aetiologies, and role of PCR in the decision on the management plan and duration of hospital stay in Jordanian children diagnosed with aseptic meningitis. Methods This retrospective observational cohort study included children diagnosed with meningitis who were admitted to the paediatric ward at Jordan University Hospital (JUH) during the period from January 2016 to August 2020. Patients were identified through the ICD9 discharge code of meningitis. Read More

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Metagenomic Next-Generation Sequencing for Accurate Diagnosis of Acute HIV Infection with Aseptic Meningitis: A Case Report.

Infect Drug Resist 2022 16;15:2529-2536. Epub 2022 May 16.

Department of Infectious Disease, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, 321000, People's Republic of China.

Background: Although individuals infected with HIV for the first time manifest a series of acute syndromes, most patients show mild or no symptoms, which complicates the initial clinical diagnosis. Early diagnosis is important for effective prevention and management of patients. Metagenomic next-generation sequencing technology (mNGS) can rapidly detect a wide range of pathogenic microorganisms, even in atypical cases. Read More

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In-vitro antiviral activity of doxepin hydrochloride against group B coxsackievirus.

Virus Res 2022 May 19;317:198816. Epub 2022 May 19.

School of Pharmaceutical Sciences, Shenzhen University, Shenzhen, 518060, China; College of Pharmacy, Shenzhen Technology University, Shenzhen, 518118, China. Electronic address:

Group B coxsackievirus is an enterovirus that can cause a variety of diseases, including myocarditis, aseptic meningitis, and hand, foot, and mouth disease. Currently, there is no effective antiviral drug against this virus. In this study, we used a cytopathic effect-based viral inhibition assay to screen an FDA-approved drug library and found that doxepin hydrochloride had potential antiviral activity. Read More

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The nonstructural protein 2C of Coxsackie B virus has RNA helicase and chaperoning activities.

Virol Sin 2022 May 16. Epub 2022 May 16.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 100081, China. Electronic address:

RNA-remodeling proteins, including RNA helicases and chaperones, play vital roles in the remodeling of structured RNAs. During viral replication, viruses require RNA-remodeling proteins to facilitate proper folding and/or re-folding the viral RNA elements. Coxsackieviruses B3 (CVB3) and Coxsackieviruses B5 (CVB5), belonging to the genus Enterovirus in the family Picornaviridae, have been reported to cause various infectious diseases such as hand-foot-and-mouth disease, aseptic meningitis, and viral myocarditis. Read More

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Reactogenicity to ChAdOx1 nCoV-19 vaccine in health care workers: A multicenter observational study in Sri Lanka.

Ceylon Med J 2021 Dec;66(4):177-184

University of Ruhuna, Sri Lanka.

Introduction: The acceptability of a vaccine is an important factor during mass vaccination programs and this is largely dependent on the symptoms of local and systemic reactogenicity. There is paucity of data on the systemic and local reactions experienced by COVD-19 vaccine recipients in South Asia.

Objectives: To identify the early local and systemic reactogenicity of ChAdOx1 nCoV-19 vaccine. Read More

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December 2021

Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71.

Front Cell Infect Microbiol 2022 25;12:873304. Epub 2022 Apr 25.

School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Enterovirus 71 (EV71) is the main pathogenic virus that causes hand, foot, and mouth disease (HFMD). Studies have reported that EV71-induced infections including aseptic meningitis, acute flaccid paralysis, and even neurogenic pulmonary edema, can progress to severe neurological complications in infants, young children, and the immunosuppressed population. However, the mechanisms through which EV71 causes neurological diseases have not been fully explored. Read More

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Cerebrospinal Fluid Procalcitonin-A Potential Biomarker for Post-Craniotomy Bacterial Meningitis.

Neurol India 2022 Mar-Apr;70(2):721-726

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Background: The literature regarding the utility of cerebrospinal fluid (CSF) procalcitonin (PCT) in the diagnosis of post-craniotomy bacterial meningitis and differentiating it from aseptic meningitis is sparse.

Materials And Methods: CSF total WBC count, sugar, protein, and PCT were measured in febrile patients with suspected post-craniotomy meningitis during the first 30 days following an intradural cranial procedure for non-trauma indications. Patients were diagnosed as postoperative bacterial meningitis if CSF culture was positive (PBM, n = 28) or postoperative aseptic meningitis if CSF culture was sterile and there was no evidence of systemic infection (PAM, n = 31). Read More

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Neurological manifestations in mevalonate kinase deficiency: A systematic review.

Mol Genet Metab 2022 Apr 30. Epub 2022 Apr 30.

Sorbonne University, Department of Internal Medicine, AP-HP, Hôpital Tenon, Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses Inflammatoire (CEREMAIA), Paris, France. Electronic address:

Introduction: Mevalonate kinase deficiency (MKD) is a monogenic auto-inflammatory disease. Its manifestations range from partial MKD to mevalonic aciduria (MVA). All patients display a periodic fever, and MVA patients additionally exhibit severe neurological involvement. Read More

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Uveomeningeal syndrome presenting with bilateral optic disc edema and multiple evanescent white dots syndrome (MEWDS).

Am J Ophthalmol Case Rep 2022 Jun 20;26:101538. Epub 2022 Apr 20.

Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA.

Purpose: To report a uveomeningeal syndrome with bilateral optic disc edema and a MEWDS-like presentation.

Observations: A 17-year-old female experienced daily fevers for 3 days (ranging from 101.4 F to 102 F), then received the first dose of the Pfizer SARS-CoV-2 vaccine nearly three weeks later. Read More

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West Nile Virus and Other Domestic Nationally Notifiable Arboviral Diseases - United States, 2020.

MMWR Morb Mortal Wkly Rep 2022 May 6;71(18):628-632. Epub 2022 May 6.

Arthropod-borne viruses (arboviruses) are transmitted to humans primarily through the bite of infected mosquitoes and ticks. West Nile virus (WNV), mainly transmitted by Culex species mosquitos, is the leading cause of domestically acquired arboviral disease in the United States (1). Other arboviruses cause sporadic cases of disease and occasional outbreaks. Read More

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Rare clinical manifestations in systemic lupus erythematosus: a review on frequency and clinical presentation.

Clin Exp Rheumatol 2022 May 29;40 Suppl 134(5):93-102. Epub 2022 Apr 29.

Rheumatology Unit, Azienda Ospedaliero Universitaria Pisana, and Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Objectives: The purpose of this study was to review the frequency and clinical presentation of the rarest clinical manifestations of systemic lupus erythematosus (SLE).

Methods: A list of 6 rare SLE manifestations were defined: gastrointestinal, liver, pulmonary, cardiac, ocular and neurological manifestations. Each topic was assigned to a pair of authors to perform a literature search and article review. Read More

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Clinical, Laboratory, and Molecular Epidemiology of an Outbreak of Aseptic Meningitis Due to a Triple-Recombinant Echovirus in Ashburton, New Zealand.

Viruses 2022 03 22;14(4). Epub 2022 Mar 22.

Microbiology Department, Virology/Serology Section, Canterbury Health Laboratories, Christchurch 8011, New Zealand.

Here, we describe a small enterovirus outbreak including nine cases of aseptic meningitis in a New Zealand hospital in 2017. Most patients had a lymphocytic predominance in the CSF, their length of stay was short, and there were no paediatric cases or ICU admissions. VP1 genotyping revealed that the outbreak was caused by an echovirus E30 strain closely related to strains reported from the US, UK, Brazil, and Denmark. Read More

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Myelin Oligodendrocyte Glycoprotein-Associated Disorders Post-ChAdOx1 Vaccination.

Cureus 2022 Mar 15;14(3):e23197. Epub 2022 Mar 15.

Neurology, Aster Medcity, Kochi, IND.

ChAdOx1 nCoV-19 vaccine (AstraZeneca) has been associated with rare adverse events following vaccination such as thrombosis with thrombocytopenia syndrome, inflammatory myositis, and autoimmune encephalitis. Para-infectious or post-infectious myelin oligodendrocyte glycoprotein-associated disorders (MOGAD) have been reported in association with coronavirus disease. However, post-vaccine MOGAD (PV-MOGAD) has not yet been reported. Read More

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Atomic Structures of Coxsackievirus B5 Provide Key Information on Viral Evolution and Survival.

J Virol 2022 May 20;96(9):e0010522. Epub 2022 Apr 20.

Key Laboratory of Infection and Immunity, Institute of Biophysicsgrid.418856.6, Chinese Academy of Sciences, Beijing, China.

Coxsackie virus B5 (CVB5), a main serotype in human Enterovirus B (EVB), can cause severe viral encephalitis and aseptic meningitis among infants and children. Currently, there is no approved vaccine or antiviral therapy available against CVB5 infection. Here, we determined the atomic structures of CVB5 in three forms: mature full (F) particle (2. Read More

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Whole-genome analysis of coxsackievirus B3 reflects its genetic diversity in China and worldwide.

Virol J 2022 Apr 18;19(1):69. Epub 2022 Apr 18.

WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Beijing, 102206, People's Republic of China.

Background: Coxsackievirus B3 (CVB3) has emerged as an active pathogen in myocarditis, aseptic meningitis, hand, foot, and mouth disease (HFMD), and pancreatitis, and is a heavy burden on public health. However, CVB3 has not been systematically analyzed with regard to whole-genome diversity and recombination. Therefore, this study was undertaken to systematically examine the genetic characteristics of CVB3 based on its whole genome. Read More

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Pathological Characteristics of Echovirus 30 Infection in a Mouse Model.

J Virol 2022 May 14;96(9):e0012922. Epub 2022 Apr 14.

Department of Medical Microbiology, Weifang Medical Universitygrid.268079.2, Weifang, People's Republic of China.

Echovirus 30 (E30), a member of species B enterovirus, is associated with outbreaks of aseptic meningitis and has become a global health emergency. However, the pathogenesis of E30 remains poorly understood due to the lack of appropriate animal models. In this study, we established a mouse infection model to explore the pathogenicity of E30. Read More

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Fabry Disease with Aseptic Meningitis: A Case Series and Literature Review of an Underestimated Clinical Presentation.

Curr Med Sci 2022 Apr 13;42(2):274-279. Epub 2022 Apr 13.

Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.

Objective: Fabry disease (FD) is an X-linked lysosomal storage disease caused by the mutation in the α-galactosidase A gene that leads to a consequently decreased α-galactosidase A enzyme activity and a series of clinical presentations. However, FD accompanied with aseptic meningitis can be relatively scarce and rarely reported, which leads to significant clinical misdiagnosis of this disease.

Methods: Sixteen patients diagnosed with FD based on a decreased activity of α-galactosidase A enzyme and/or genetic screening were identified through a 6-year retrospective chart review of a tertiary hospital. Read More

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Primary Sjögren's Syndrome Presenting as Recurrent Ischemic Strokes.

Neurohospitalist 2022 Apr 23;12(2):341-345. Epub 2021 Sep 23.

Department of Neurology, Neurological Institute (NI), Cleveland Clinic Abu Dhabi (CCAD), Abu Dhabi, United Arab Emirates.

Primary Sjogren's Syndrome (PSS) is an autoimmune exocrinopathy, with protean manifestations affecting multiple organ systems. Neurological manifestations are documented in about 20% of PSS cohorts in literature, with peripheral manifestations being commoner. Central nervous system manifestations of PSS (CNS-SS) encompass ischemic strokes, demyelinating lesions, aseptic meningitis, encephalitis, cerebellar ataxia, cognitive impairment and movement disorders. Read More

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Immune-related aseptic meningitis and strategies to manage immune checkpoint inhibitor therapy: a systematic review.

J Neurooncol 2022 May 13;157(3):533-550. Epub 2022 Apr 13.

Department of Medical Oncology, Strasbourg-Europe Cancer Institute (ICANS), 67200, Strasbourg, France.

Introduction: Immune checkpoint inhibitors (ICIs) can induce adverse neurological effects. Due to its rarity as an adverse effect, meningitis has been poorly described. Therefore, meningitis diagnosis and management can be challenging for specialists. Read More

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Aseptic Meningitis in Oral Medicine: Exploring the Key Elements for a Challenging Diagnosis: A Review of the Literature and Two Case Reports.

Int J Environ Res Public Health 2022 03 25;19(7). Epub 2022 Mar 25.

Oral Medicine Unit, Department of Neurosciences, Reproductive and Oral Sciences, "Federico II" University of Naples, 80131 Naples, Italy.

Aseptic meningitis (AM) is a potentially severe and life-threatening disease characterized by meningeal inflammation, usually with mononuclear pleocytosis. It represents a challenging and controversial issue in medicine for multiple etiologies, classification, and difficult diagnosis in the face of nonspecific sets of signs and symptoms. In the area of interest of oral medicine, in specific clusters of patients, even if rare, the occurrence of aseptic meningitis can pose a diagnostic and management dilemma in the following potential etiologies: (i) systemic diseases with oral and meningeal involvement, which include Behçet's disease and Sjögren syndrome; (ii) drug-induced aseptic meningitis; (iii) aseptic viral meningitis, mostly related to herpes simplex virus infection and hand, foot, and mouth disease, caused by enteroviruses. Read More

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Development of a rapid neutralization assay for the detection of neutralizing antibodies against coxsackievirus B1.

Diagn Microbiol Infect Dis 2022 Jun 16;103(2):115676. Epub 2022 Mar 16.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, PR China.

Coxsackievirus B1 (CVB1) is a major pathogen that causes viral myocarditis and aseptic meningitis and is implicated as a cause of type 1 diabetes mellitus. The rapid detection of neutralizing antibodies can help in the prevention and diagnosis of viral infection. The traditional cytopathic effect (CPE)-based neutralization assay (Nt-CPE) is time-consuming and labor-intensive. Read More

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Varicella-Zoster meningitis with normal CSF cellularity: A rare case report.

IDCases 2022 25;28:e01484. Epub 2022 Mar 25.

Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Qatar.

Varicella-zoster virus (VZV) meningitis is a one of the manifestations of VZV reactivation which usually presents with fever, headache, and is sometimes preceded by a dermatomal vesicular rash. CSF analysis is the cornerstone investigation in helping to identify the causative organism or in orienting the physician toward a possible agent. CSF analysis in Viral meningitis usually reveals lymphocytic pleocytosis. Read More

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Immunogenicity of Mumps Virus Genotype G Vaccine Candidates in Jeryl Lynn-Immunized Mice.

J Virol 2022 04 7;96(8):e0198321. Epub 2022 Apr 7.

Department of Infectious Diseases, University of Georgiagrid.213876.9 College of Veterinary Medicine, Athens, Georgia, USA.

Mumps virus (MuV) causes a highly contagious human disease characterized by the enlargement of the parotid glands. In severe cases, mumps can lead to neurological complications such as aseptic meningitis and encephalitis. Vaccination with the attenuated Jeryl Lynn (JL) MuV vaccine has dramatically reduced the incidence of MuV infection. Read More

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[Neuroendoscopy-assisted microneurosurgery for cerebellopontine angle cholesteatoma].

Zhonghua Yi Xue Za Zhi 2022 Apr;102(13):965-968

Nanjing Medical University, Nanjing 211166, China.

A total of 49 patients with cerebellopontine angle cholesteatoma from the Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University between January 2013 and January 2021 were recruited. All patients were evaluated by MRI scan before surgery and tumor resection was performed under microscope via retrosigmoid sinus approach. Then residual tumor was searched with 0°and 30°neuroendoscopy, and tumor resection was performed. Read More

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Aseptic Meningitis and mRNA Coronavirus Disease 2019 Vaccine.

Infect Chemother 2022 Mar;54(1):182

Honorary professor, Dr DY Patil University, Pune, India.

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Reply: Diagnose Aseptic Meningitis Caused by SARS-CoV-2 Vaccination Only After Ruling Out All Possible Differentials.

Sang Taek Heo

Infect Chemother 2022 Mar;54(1):187-188

Department of Internal Medicine, College of Medicine, Jeju National University, Jeju, Korea.

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Reply: Aseptic Meningitis and mRNA Coronavirus Disease 2019 Vaccine.

Sang Taek Heo

Infect Chemother 2022 Mar;54(1):183-184

Department of Internal Medicine, College of Medicine, Jeju National University, Jeju, Korea.

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Clinical course and neurological sequels after tick-borne encephalitis in children - case report.

Ann Agric Environ Med 2022 Mar 19;29(1):162-167. Epub 2021 Mar 19.

Collegium Medicum, Jan Kochanowski University, Kielce, Poland.

Introduction: Tick-borne encephalitis (TBE) is a neurotropic, tick-transmitted infection. Clinical presentation ranges from mild aseptic meningitis to severe encephalitis, and may result in long-term neurological sequels.

Objective: The aim of the study is to present the clinical features of TBE in children, and the laboratory findings, in order to identify neurological sequels and the risk of cognitive deficits in long-term TBE infections. Read More

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Is it all about age? Clinical characteristics of kawasaki disease in the extremely young: PeRA research group experience.

Postgrad Med 2022 Apr 4:1-6. Epub 2022 Apr 4.

Department of Pediatric Rheumatology, Istanbul University Faculty of Medicine Fatih, Istanbul, Turkey.

Objectives: In the evaluation of children with Kawasaki disease (KD), the age of onset is important and complications may occur if the distinctive features are not assessed accordingly. The objective of the study is to define the clinical and laboratory presentations and treatment outcomes of KD in infants ≤6 months of age compared to those >6 months multicentrically.

Methods: This retrospective study reviewed the medical records of the patients diagnosed with KD and followed up between January 2009 and January 2019. Read More

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