3,867 results match your criteria Aseptic Meningitis


Severe cryopyrin-associated periodic syndrome first characterized by early childhood-onset sensorineural hearing loss - Case report and literature review.

Int J Pediatr Otorhinolaryngol 2019 Jan 28;120:68-72. Epub 2019 Jan 28.

Division of Pediatric Rheumatology, Department of Pediatrics, IWK Health Centre, 5850/5980 University Ave, PO Box 9700, Halifax, NS, B3K 6R8, Canada. Electronic address:

Infant-onset bilateral sensorineural hearing loss is a key presenting symptom of the autoinflammatory cryopyrin-associated periodic syndrome. Other symptoms include periodic fever, cold-induced urticaria-like rash, chronic aseptic meningitis, polyarticular arthralgias, and renal AA amyloidosis. Early recognition and treatment with interleukin-1 blockade are critical for preventing disabling or fatal complications. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.037DOI Listing
January 2019
1 Read

Impact of the introduction of the Haemophilus influenzae type b conjugate vaccine in an urban setting in southern India.

Vaccine 2019 Feb 13. Epub 2019 Feb 13.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21218, USA.

Introduction: Haemophilus influenzae type b was the leading cause of bacterial meningitis in infants and children below the age of two years prior to the introduction of H. influenzae type b conjugate vaccines. In December 2011, the Indian government introduced H. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.080DOI Listing
February 2019
1 Read

Zika Virus-Associated Aseptic Meningitis and Guillain-Barre Syndrome in a Traveler Returning from Latin America: a Case Report and Mini-Review.

Curr Infect Dis Rep 2019 Feb 15;21(1). Epub 2019 Feb 15.

Department of Medicine, University of Toronto, Toronto, Canada.

ZIKV-associated Guillain-Barré syndrome presents with an accelerated clinical course compared to classic post-infectious Guillain-Barré syndrome. Clinicians should anticipate and screen patients with ZIKV infection for neurologic complications bearing in mind that these may manifest during the acute viremic phase or during early convalescence. Read More

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http://dx.doi.org/10.1007/s11908-019-0661-1DOI Listing
February 2019
1 Read

Vogt-Koyanagi-Harada Disease, a Rare Entity in Spain: The Challenge of Worldwide Immigration and Globalization.

Eur J Case Rep Intern Med 2018 26;5(7):000886. Epub 2018 Jul 26.

Ophthalmology Department, Baza Hospital, Granada, Spain.

Vogt-Koyanagi-Harada disease is rare, mediated by autoimmune melanocyte inflammation and facilitated by genetic predisposition. The main clinical features include uveitis, meningitis, tinnitus and sensorineural deafness, and skin and hair depigmentation. It usually develops in four consecutive stages: prodromal, acute uveitic, convalescent, and chronic or recurrent. Read More

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http://dx.doi.org/10.12890/2018_000886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346778PMC

Posterior fossa decompression for Chiari malformation type I: clinical and radiological presentation, outcome and complications in a retrospective series of 105 procedures.

Acta Neurol Belg 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurosurgery, University Hospitals, Leuven, Belgium.

Objective: Determining clinical and radiological characteristics, complication rates and outcome for patients undergoing posterior fossa decompression (PFD) and duraplasty for Chiari malformation type I (CM-I).

Methods And Materials: Retrospective, single-university hospital study of all PFDs for CM-I between January 1995 and December 2016.

Results: PFD was performed in 105 patients with CM-I (n = 105), of whom 62 suffered from associated syringomyelia and 37 were pediatric cases. Read More

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http://dx.doi.org/10.1007/s13760-019-01086-7DOI Listing
February 2019
1 Read

Viral (aseptic) meningitis: A review.

J Neurol Sci 2019 Jan 31;398:176-183. Epub 2019 Jan 31.

Division of Hospital Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pinnacle, United States.

Viral meningitis is an inflammation of the meninges associated with acute onset of meningeal symptoms and fever, pleocytosis of the cerebrospinal fluid, and no growth on routine bacterial culture. It is sometimes associated with viral encephalitis and meningoencephalitis. Viruses reach the central nervous system (CNS) hematogenously or in a retrograde manner from nerve endings. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.050DOI Listing
January 2019
1 Read

Immunogenicity and safety of the new MMR vaccine containing measles AIK-C, rubella Takahashi, and mumps RIT4385 strains in Japanese children: a randomized phase I/II clinical trial.

Hum Vaccin Immunother 2019 Feb 6. Epub 2019 Feb 6.

b Japan Vaccine Co., Ltd .

Domestic measles, mumps, and rubella combined (MMR) vaccines were discontinued in 1993 in Japan because of the unexpected high incidence of aseptic meningitis. The introduction of an effective MMR vaccine with lower reactogenicity has been expected. A new MMR vaccine (JVC-001) was developed, using mumps RIT4385 strain in combination with Japanese measles AIK-C strain and rubella Takahashi strain (MR) vaccine. Read More

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http://dx.doi.org/10.1080/21645515.2019.1578591DOI Listing
February 2019
6 Reads

Opsoclonus in a child with neuroborreliosis: Case report and review of the literature.

Arch Pediatr 2019 Feb 14;26(2):118-119. Epub 2019 Jan 14.

Service de neurologie pédiatrique, CHU d'Angers, 4, rue Larrey, 49100 Angers, France.

Opsoclonus consists of massive erratic rapid eye jerks. They may occur in isolation or in association with myoclonus and ataxia, i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0929693X183026
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http://dx.doi.org/10.1016/j.arcped.2018.11.013DOI Listing
February 2019
5 Reads

Aseptic meningitis as onset of Kawasaki disease.

Minerva Pediatr 2019 Jan 17. Epub 2019 Jan 17.

First Division of Infectious Disease, Cotugno Hospital, Azienda Ospedaliera dei Colli, Naples, Italy.

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http://dx.doi.org/10.23736/S0026-4946.19.05384-2DOI Listing
January 2019
4 Reads

Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Jan 10. Epub 2019 Jan 10.

Department of Children's Oncology, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic.

Aims: Enteroviruses (EVs) are the most common agents of aseptic meningitis. Some serotypes can cause serious neuroinfection leading to death. The aim of this study was to determine the representation of EVs in the etiology of aseptic meningitis in children and to analyze the demographic, clinical, laboratory, and epidemiological characteristics of patients with EV meningitis. Read More

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http://biomed.papers.upol.cz/doi/10.5507/bp.2018.082.html
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http://dx.doi.org/10.5507/bp.2018.082DOI Listing
January 2019
7 Reads

Acute transverse myelitis - A rare clinical manifestation of Lyme neuroborreliosis.

IDCases 2019 29;15:e00479. Epub 2018 Dec 29.

Division of Infectious Diseases, North Memorial Health Hospital, Minneapolis, MN, United States.

Acute transverse myelitis (ATM) is a rare, potentially devastating neurological syndrome that has variety of causes, infectious being one of them. Lyme disease (LD) is the most common vector borne zoonosis in the United States (U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22142509183019
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http://dx.doi.org/10.1016/j.idcr.2018.e00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317275PMC
December 2018
5 Reads

Kawasaki disease shock syndrome: clinical characteristics and possible use of IL-6, IL-10 and IFN-γ as biomarkers for early recognition.

Pediatr Rheumatol Online J 2019 Jan 5;17(1). Epub 2019 Jan 5.

Department of Rheumatology Immunology and Allergy, Children's Hospital, Zhejiang University School of Medicine, No.57, Zhugan Lane, Yan-an Road, Hangzhou, 310003, China.

Background: As an acute febrile and inflammatory disease, Kawasaki disease (KD) could develop Kawasaki disease shock syndrome (KDSS) sometimes. However its pathogenesis was still not well known. This study was to learn more about the clinical features and evaluate the role of cytokines in the pathogenesis of KDSS. Read More

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http://dx.doi.org/10.1186/s12969-018-0303-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321686PMC
January 2019
2 Reads

Echovirus plays a major role in natural recombination in the coxsackievirus B group.

Arch Virol 2019 Jan 1. Epub 2019 Jan 1.

Medical College, Jiangsu University, 301 Xuefu road, Zhenjiang, 212013, People's Republic of China.

Coxsakievirus (CV) B4, CVB5, and CVA9 belong to the species Enterovirus B. These viruses can cause viral encephalitis, aseptic meningitis, pancreatitis, flaccid paralysis, dilated myocarditis, and hand, foot, and mouth disease (HFMD). In order to analyze the evolution of CVB4, CVB5, and CVA9, we analyzed all of the available genome sequences of Enterovirus B (EVB) isolates and found that there were 12 putative recombination events that produced CVB4, 13 putative recombination events that produced CVB5, and 10 putative recombination events that produced CVA9. Read More

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http://dx.doi.org/10.1007/s00705-018-4114-1DOI Listing
January 2019
2 Reads

Rheumatoid meningitis sine arthritis.

J Neuroimmunol 2019 Mar 19;328:73-75. Epub 2018 Dec 19.

Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Address: 211 South 9(th) Street, Walnut Towers Suite 210, Philadelphia, PA 19107, United States. Electronic address:

Rheumatoid meningitis is a rare and very serious extra-articular manifestation of rheumatoid arthritis. We present a case of a 7()year-old female with no history of arthritis who developed stroke-like symptoms, seizures, psychosis and compulsive behavior. Serial brain magnetic resonance images (MRI) over four months demonstrated progressive interhemispheric meningeal thickening. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183048
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http://dx.doi.org/10.1016/j.jneuroim.2018.12.001DOI Listing
March 2019
4 Reads

Molecular characterization of an outbreak of enterovirus-associated meningitis in Mossel Bay, South Africa, December 2015-January 2016.

BMC Infect Dis 2018 Dec 29;18(1):709. Epub 2018 Dec 29.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa and the National Health Laboratory Service, Anzio Road, Observatory, Cape Town, 7925, South Africa.

Background: Human enteroviruses (HEVs) are common causal agents of aseptic meningitis in young children. Laboratory and syndromic surveillance during December 2015 and January 2016 noted an unusually high number of paediatric aseptic meningitis cases at a hospital in Mossel Bay, Western Cape Province, South Africa. HEV was detected in clinical samples, prompting an outbreak investigation. Read More

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http://dx.doi.org/10.1186/s12879-018-3641-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311073PMC
December 2018
1 Read

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro.

Microb Pathog 2019 Mar 21;128:106-111. Epub 2018 Dec 21.

Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China. Electronic address:

As one of the major causative agents of hand, foot and mouth disease (HFMD), enterovirus 71 (EV71) is a small, non-enveloped positive stranded RNA virus. Children suffering EV71 infection may cause severe symptoms including neurological complications, pulmonary edema and aseptic meningitis. EV71 is a neurotropic virus and it can cause the damage of nervous cells, cytokine storm and toxic substance. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.12.032DOI Listing
March 2019
2 Reads

Haploidentical transplantation using low-dose alemtuzumab: Comparison with haploidentical transplantation using low-dose thymoglobulin.

Eur J Haematol 2019 Mar 9;102(3):256-264. Epub 2019 Jan 9.

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Objectives: To establish the optimal strategy for haploidentical hematopoietic stem cell transplantation (HSCT).

Methods: We performed a prospective study on haploidentical HSCT using low-dose alemtuzumab. Alemtuzumab was added at 0. Read More

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http://doi.wiley.com/10.1111/ejh.13204
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http://dx.doi.org/10.1111/ejh.13204DOI Listing
March 2019
7 Reads

Mollaret Meningitis with a High Level of Cytokines in the Cerebrospinal Fluid Successfully Treated by Indomethacin.

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Japan.

A rare case of Mollaret meningitis characterized by four recurrent episodes of aseptic meningitis during a three-year period is reported. The patient showed a high fever and severe headache accompanied by a high level of cerebrospinal fluid (CSF) cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). The symptoms and high CSF cytokines were resolved immediately after introducing indomethacin treatment. Read More

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http://dx.doi.org/10.2169/internalmedicine.1676-18DOI Listing
December 2018

Rheumatoid meningitis: A rare cause of aseptic meningitis with frequently stroke-like episodes.

Neurol Clin Pract 2018 Oct;8(5):451-455

Department of Neurology (SS, HB, CG, GT, TM), Center for Internal Medicine (US), and Institute of Neuropathology (JM), University Hospital Hamburg-Eppendorf; and Klinik für Rheumatologie und Immunologie (CI-K), Klinikum Bad Bramstedt, Germany.

Background: Rheumatoid meningitis (RM) is a rare manifestation of rheumatoid arthritis (RA) and may present with stroke-like episodes. We describe diagnostic findings and the outcome in patients with RM.

Methods: We identified 6 patients with RM in different stages of RA mostly admitted with stroke-like episodes or common features of meningitis. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276349PMC
October 2018

Increased risk for aseptic meningitis after amoxicillin or amoxicillin-clavulanic acid in males: A signal revealed by subset disproportionality analysis within a global database of suspected adverse drug reactions.

Pharmacoepidemiol Drug Saf 2018 Dec 17. Epub 2018 Dec 17.

Research Section, Uppsala Monitoring Centre, Uppsala, Sweden.

Purpose: Drug-induced aseptic meningitis (DIAM) is an inflammation of the membranes of the central nervous system caused by certain medications. It is a rare clinical entity whose risk factors are not yet fully elucidated. A local pattern of disproportionality within a global database of suspected adverse drug reactions (ADRs) revealed an increased reporting of aseptic meningitis and amoxicillin-clavulanic acid (AC) in males. Read More

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http://dx.doi.org/10.1002/pds.4707DOI Listing
December 2018
1 Read

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

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http://link.springer.com/10.1007/s12250-018-0071-9
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http://dx.doi.org/10.1007/s12250-018-0071-9DOI Listing
December 2018
9 Reads

Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis.

Neurol Clin Neurosci 2018 Nov 24;6(6):191-193. Epub 2018 Sep 24.

Department of Neurology Shin-yurigaoka General Hospital Kanagawa Japan.

We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Read More

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http://doi.wiley.com/10.1111/ncn3.12232
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http://dx.doi.org/10.1111/ncn3.12232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282518PMC
November 2018
17 Reads

Genetic diversity of the enteroviruses detected from cerebrospinal fluid (CSF) samples of patients with suspected aseptic meningitis in northern West Bank, Palestine in 2017.

PLoS One 2018 10;13(12):e0202243. Epub 2018 Dec 10.

Rafeedia Medical Laboratory Hospital, Palestinian Ministry of Health, Nablus, Palestine.

Background: Human enterovirus genus showed a wide range of genetic diversity.

Objectives: To investigate the genetic diversity of the enteroviruses isolated in 2017 in northern West Bank, Palestine.

Study Design: 249 CSF samples from aseptic meningitis cases were investigated for HEV using two RT-PCR protocols targeting the 5' NCR and the VP1 region of the HEV genome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202243PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287809PMC
December 2018
2 Reads
3.234 Impact Factor

Causal relationship between immunological responses and adverse reactions following vaccination.

Authors:
Tetsuo Nakayama

Vaccine 2019 Jan 30;37(2):366-371. Epub 2018 Nov 30.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, 5-9-1 Shirokane Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses. Vaccines stimulate the innate immunity of host immunological defense mechanisms and induce the development of specific acquired immunity. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.11.045DOI Listing
January 2019
1 Read

Pearls & Oy-sters: Neuro-Sweet disease presenting as ischemic stroke and aseptic meningitis.

Neurology 2018 Dec;91(23):e2197-e2199

From the Department of Neurology (A.S.D., S.E.C., M.A.B., N.S.R., N.V.) and Department of Medicine, Division of Rheumatology (S.H.U.), Massachusetts General Hospital, and Department of Neurology, Brigham and Women's Hospital (A.S.D., S.E.C.), Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000006628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282232PMC
December 2018
1 Read

A Rare Case of Levetiracetam and Drug-Induced Idiopathic Aseptic Meningitis in a Pediatric Patient.

Pharmacotherapy 2019 Jan 11;39(1):109-113. Epub 2018 Dec 11.

Hovnanian Children's Hospital at Hackensack Meridian Health, Hackensack, New Jersey.

Levetiracetam (LEV) is a pyrrolidine derivative antiepileptic medication used for the treatment of seizures in pediatric and adult patients. We report a case of probable LEV-induced aseptic meningitis in a 13-year-old girl. The patient received LEV for a generalized seizure disorder and presented with symptoms 5 days after medication initiation. Read More

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http://dx.doi.org/10.1002/phar.2198DOI Listing
January 2019
2 Reads

Combined testing for herpes simplex virus and Mycobacterium tuberculosis DNA in cerebrospinal fluid of patients with aseptic meningitis in Burkina Faso, West Africa.

J Clin Lab Anal 2018 Nov 25:e22719. Epub 2018 Nov 25.

UMR 1058, INSERM/EFS/Université de Montpellier, Montpellier, France.

Background: Little is known about the involvement of herpes simplex virus (HSV) or Mycobacterium tuberculosis (MTB) as potentially curable causes of central nervous system (CNS) infections in sub-Saharan Africa.

Objective: In this study, we developed a PCR assay dedicated to simultaneous testing of HSV1/HSV2 and MTB in Burkina Faso, a country where HSV is neglected as a cause of CNS infection and where TB prevalence is high.

Methods: A consensus HSV1/HSV2 set of primers and probe were designed and combined to primers and probe targeting the IS6110 repetitive insertion sequence of MTB. Read More

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http://dx.doi.org/10.1002/jcla.22719DOI Listing
November 2018
2 Reads

High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections.

J Neuroinflammation 2018 Nov 23;15(1):327. Epub 2018 Nov 23.

Department of Infectious Diseases, Oslo University Hospital, Ullevaal Hospital, P. O. Box 4956 Nydalen, N-0450, Oslo, Norway.

Background: The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces the activation of the kynurenine pathway (KP) with the production of neuroactive metabolites. Herein, we explored cytokine and KP responses in cerebrospinal fluid (CSF) and serum in patients with encephalitis, aseptic, and bacterial meningitis. Read More

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http://dx.doi.org/10.1186/s12974-018-1366-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260858PMC
November 2018
6 Reads

A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5.

Emerg Microbes Infect 2018 Nov 21;7(1):185. Epub 2018 Nov 21.

Institute for Biological Products Control, National Institutes for Food and Drug Control, Beijing, China.

As one of the key members of the coxsackievirus B group, coxsackievirus B5 (CV-B5) can cause many central nervous system diseases, such as viral encephalitis, aseptic meningitis, and acute flaccid paralysis. Notably, epidemiological data indicate that outbreaks of CV-B5-associated central nervous system (CNS) diseases have been reported worldwide throughout history. In this study, which was conducted to promote CV-B5 vaccine and anti-virus drug research, a 3-day-old BALB/c mouse model was established using a CV-B5 clinical isolate (CV-B5/JS417) as the challenge strain. Read More

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http://dx.doi.org/10.1038/s41426-018-0186-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246558PMC
November 2018
15 Reads

Incidence of Prolonged Systemic Steroid Treatment after Surgery for Acoustic Neuroma and Its Implications.

J Neurol Surg B Skull Base 2018 Dec 13;79(6):559-568. Epub 2018 Apr 13.

Department of Otolaryngology - Head and Neck Surgery, Weill Cornell Medical College, New York, United States.

 To determine the incidence of prolonged postoperative systemic corticosteroid therapy after surgery for acoustic neuroma as well as the indications and associated risk factors that could lead to prolonged steroid administration, and the incidence of steroid-related adverse effects.  Retrospective chart review.  Retrospective chart review of patients undergoing resection of acoustic neuroma between 2010 and 2017 at two tertiary care medical centers. Read More

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http://dx.doi.org/10.1055/s-0038-1641752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239872PMC
December 2018
9 Reads

Impact of Drinking Water Quality on the Development of Enteroviral Diseases in Korea.

Int J Environ Res Public Health 2018 11 14;15(11). Epub 2018 Nov 14.

Department of Social and Preventive Medicine, School of Medicine, Sungkyunkwan University, Suwon 440-746, Korea.

Enterovirus diseases are fecal-orally transmitted, and its transmission may be closely related with the drinking water quality and other environmental factors. This study aimed to assess the association between environmental factors including drinking water quality and the incidence of enteroviral diseases in metropolitan provinces of Korea. Using monthly number of hand-foot-mouth disease (HFMD), aseptic meningitis (AM) and acute hemorrhage conjunctivitis (AHC) cases, generalized linear Poisson model was applied to estimate the effects of environmental factors on the monthly cases. Read More

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http://www.mdpi.com/1660-4601/15/11/2551
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http://dx.doi.org/10.3390/ijerph15112551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266091PMC
November 2018
12 Reads

Recurrent Amoxicillin-Induced Aseptic Meningitis.

Can J Neurol Sci 2018 Nov;45(6):701-702

Department of Medicine (Neurology),Memorial University of Newfoundland,St. John's,Newfoundland and Labrador, Canada.

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http://dx.doi.org/10.1017/cjn.2018.348DOI Listing
November 2018
1 Read

Sero-molecular epidemiology of enterovirus-associated encephalitis in Zhejiang Province, China, from 2014 to 2017.

Int J Infect Dis 2019 Feb 10;79:58-64. Epub 2018 Nov 10.

Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang, People's Republic of China.

Background: Recently, both sporadic and outbreak aseptic meningitis caused by enteroviruses have been reported in Zhejiang Province based on a surveillance system.

Methods: This study analysed the epidemiologic features, phylogenetic characteristics and prevalence of enterovirus neutralizing antibodies (nAbs) from 2014 to 2017 in Zhejiang Province.

Results: A total of 584 samples were collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183458
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http://dx.doi.org/10.1016/j.ijid.2018.11.002DOI Listing
February 2019
14 Reads

Adenovirus-Associated Central Nervous System Disease in Children.

J Pediatr 2019 Feb 6;205:130-137. Epub 2018 Nov 6.

Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Objective: To characterize the spectrum and salient clinical features of adenovirus-associated neurologic disease in immunocompetent children.

Study Design: Previously healthy children (aged 1 month-18 years) with central nervous system (CNS) disease associated with adenovirus infection were identified via the Encephalitis Registry (1996-2016) and Microbiology Database (2000-2016) at The Hospital for Sick Children, Toronto, and by systematic review of the literature. The data were pooled and analyzed to identify the spectrum of illness, clinical outcome, and risk factors for death or neurologic impairment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183136
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http://dx.doi.org/10.1016/j.jpeds.2018.09.036DOI Listing
February 2019
18 Reads

Effects of a Public Subsidization Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan.

Jpn J Infect Dis 2018 Oct 31. Epub 2018 Oct 31.

Department of Public Health, Osaka City University Graduate School of Medicine.

Nagoya City initiated a public subsidization program for mumps vaccination using either Torii- or Hoshino-strains in August 2010. To demonstrate the effects of the program, we used publicly available information from Nagoya City to investigate the changes in immunization rate and numbers of patients who developed post-immunization adverse reactions, including post-vaccinal aseptic meningitis, in the 7 years since its initiation. We also investigated the numbers of mumps patients reported during this period by sentinel sites in a national database. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2018.276DOI Listing
October 2018
3 Reads

Neurological presentations of Bartonella henselae infection.

Neurol Sci 2019 Feb 27;40(2):261-268. Epub 2018 Oct 27.

Neurology Department, Complejo Hospitalario Universitario Pontevedra, Loureiro Crespo, 2, 36002, Pontevedra, Spain.

Objective: Neurological symptoms in patients with cat-scratch disease (CSD) have been rarely reported. The aim of this study is to analyze the frequency of neurological CSD (NCSD) and describe the disease clinical presentation, management and outcome.

Material And Methods: We retrospectively selected patients with a CSD syndrome and Bartonella IgG titers > 1:256. Read More

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http://link.springer.com/10.1007/s10072-018-3618-5
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http://dx.doi.org/10.1007/s10072-018-3618-5DOI Listing
February 2019
9 Reads

Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease.

Front Microbiol 2018 8;9:2422. Epub 2018 Oct 8.

Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.

Enterovirus (EV) infections are a major threat to global public health, and are responsible for mild respiratory illness, hand, foot, and mouth disease (HFMD), acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis epidemic. Among them, HFMD is a common pediatric infectious disease caused by EVs of the family including EV-A71, coxsackieviruses (CV)-A2, CV-A6, CV-A10, and CV-A16. Due to lack of vaccines and specific antiviral therapeutics, millions of children still suffer from HFMD. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02422
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http://dx.doi.org/10.3389/fmicb.2018.02422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186807PMC
October 2018
14 Reads

Elsberg syndrome related to varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes mellitus.

Ther Clin Risk Manag 2018 9;14:1951-1954. Epub 2018 Oct 9.

Division of Diabetes and Metabolic Diseases, Nihon University School of Medicine, Tokyo, Japan,

Patients with diabetes mellitus (DM) are at increased risk of infections, with the urinary tract being the most frequent infection site. Incomplete bladder emptying, frequent urination and abdominal distension are typical symptoms of urinary tract infections (UTIs). A 68-year-old female with a long history of poorly controlled type 2 DM (T2DM) visited our hospital complaining of urinary retention, which was initially diagnosed as cystitis by another doctor. Read More

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http://dx.doi.org/10.2147/TCRM.S178782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186309PMC
October 2018
8 Reads

Early canakinumab therapy for the sensorineural deafness in a family with Muckle-Wells syndrome due to a novel mutation of NLRP3 gene.

Clin Rheumatol 2018 Oct 18. Epub 2018 Oct 18.

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Cryopyrin-associated periodic syndrome (CAPS) is one of the autoinflammatory disorders caused by mutations in NLRP3 gene. The over-production of interleukin (IL)-1β induced by NLRP3 gene mutations plays an important role in the pathophysiology of CAPS. We diagnosed 3 patients with CAPS, who were lineal family members having a novel mutation of NLRP3 gene. Read More

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http://link.springer.com/10.1007/s10067-018-4331-8
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http://dx.doi.org/10.1007/s10067-018-4331-8DOI Listing
October 2018
13 Reads
1.774 Impact Factor

Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations.

Mult Scler Relat Disord 2019 Jan 3;27:30-33. Epub 2018 Oct 3.

UT Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, Texas, TX 75235, United States.

Objective: To describe 2 atypical cases with Anti-MOG antibody related demyelinating syndrome.

Methodology: Case series.

Results: We present two cases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183036
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http://dx.doi.org/10.1016/j.msard.2018.10.003DOI Listing
January 2019
3 Reads

A Teenage Girl With Aseptic Meningitis and Abdominal Pain.

Pediatr Infect Dis J 2018 Oct 5. Epub 2018 Oct 5.

Division of Infectious Diseases, Children's Hospital of Michigan, Detroit, MI, USA.

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http://Insights.ovid.com/crossref?an=00006454-900000000-9651
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http://dx.doi.org/10.1097/INF.0000000000002213DOI Listing
October 2018
2 Reads

Rapidly progressive encephalopathy caused by Coxsackie meningoencephalitis in an elderly male.

J Neurovirol 2018 Dec 5;24(6):780-785. Epub 2018 Oct 5.

Department of Neurology, Division of Neurocritical Care and Program in Trauma, University of Maryland Medical Center, Baltimore, MD, USA.

Enteroviruses and Coxsackie viruses are common causes of aseptic meningitis and encephalitis in children. These infections usually have a benign, self-limited course. However, they can have a florid presentation in immunocompromised patients, such as neonates, patients exposed to immunosuppressive drugs, such as transplant recipients and patients with agammaglobulinemia. Read More

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http://link.springer.com/10.1007/s13365-018-0676-7
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http://dx.doi.org/10.1007/s13365-018-0676-7DOI Listing
December 2018
10 Reads

Subdural Hematoma as a Consequence of Labor Epidural Analgesia.

Asian J Neurosurg 2018 Jul-Sep;13(3):931-934

Department of Radiology, Sacred Heart of Jesus Hospital, Benevento, Italy.

Subdural hematoma (SDH) following labor epidural analgesia is a rare neurological complication. SDH is a late complication of this procedure; it is caused by a leak of cerebrospinal fluid that may damage the vascular structures of the brain. Persistent headache in the days after labor epidural analgesia is a nonspecific clinical symptom caused by hematoma. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_115_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159069PMC
October 2018
2 Reads

Epstein-barr virus-associated encephalitis in a case-series of more than 40 patients.

Wiad Lek 2018;71(6):1224-1230

Sumy State University, Sumy, Ukraine.

Objective: Introduction: Epstein-Barr virus (EBV) infection can present with neurologic manifestations including encephalitis, aseptic meningitis, Guillain-Barre syndrome, and many others. Most reported cases have been in children. Little is known about EBV encephalitis in adults. Read More

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January 2018
14 Reads

Recurrent aseptic meningitis with mutations: a novel pathogenesis of recurrent meningitis successfully treated by eculizumab.

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Neurology, Kobe City Medical Center General Hospital, Kobe, Japan.

We report the case of a patient with mutations who experienced recurrent aseptic meningitis 121 times over 16 years before developing paroxysmal nocturnal haemoglobinuria (PNH). Each episode was preceded by urticaria and arthralgia. After developing PNH, haemolysis occurred prior to meningitis. Read More

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http://dx.doi.org/10.1136/bcr-2018-225910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169622PMC
September 2018
2 Reads

Hemorrhagic Stroke and Cerebral Venous Thrombosis: Rare Neurological Sequelae of Chickenpox Infection.

Ann Indian Acad Neurol 2018 Jul-Sep;21(3):228-232

Department of Medicine, VMMC and Safdarjung Hospital, New Delhi, India.

Chickenpox (varicella) is primarily a disease of childhood which occurs due to infection with varicella-zoster virus (VZV). Primary VZV infection is rare in adults due to exposure in early childhood in our country. In adults, it is associated with some serious systemic and neurological complications which can follow both primary infection and reactivation of VZV. Read More

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http://www.annalsofian.org/text.asp?2018/21/3/228/240428
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http://dx.doi.org/10.4103/aian.AIAN_421_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137630PMC
September 2018
17 Reads

Neurological complications of immune checkpoint inhibitors: what happens when you 'take the brakes off' the immune system.

Ther Adv Neurol Disord 2018 14;11:1756286418799864. Epub 2018 Sep 14.

Chief Neuromuscular Division, Thomas Jefferson University, Philadelphia, PA Chief, Neuroimmunology Unit, Department of Pathophysiology, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Patients with advanced malignancies treated with immune checkpoint inhibitors are at increased risk for developing immune-related neurological complications. It is a phenomenon of immunological twist when immunotherapy against co-stimulatory molecules activates previously normal T cells to kill tumor cells but, in so doing, the T cells become unrestrained, triggering other autoimmune diseases for which conventional immunotherapy is needed. The most common autoimmune neurological diseases, usually occurring within 2-12 weeks after immune checkpoint inhibitor initiation, include: inflammatory myopathies, myasthenia gravis, acute and chronic demyelinating polyradiculoneuropathies, vasculitic neuropathies, isolated cranial neuropathies, aseptic meningitis, autoimmune encephalitis, multiple sclerosis and hypophysitis. Read More

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http://dx.doi.org/10.1177/1756286418799864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144585PMC
September 2018
8 Reads

Treatment of a symptomatic cervical perineural cyst with ultrasound-guided cervical selective nerve root block: A case report.

Medicine (Baltimore) 2018 Sep;97(37):e12412

Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.

Rationale: Symptomatic cervical perineural cysts are extremely rare, and they cause radicular pain by compressing the cervical nerve root. Several methods have been applied to manage the radicular pain induced by cervical perineural cysts, including medication, percutaneous procedures, and surgery. However, these methods are associated with various outcomes and complications. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809140-0009
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http://dx.doi.org/10.1097/MD.0000000000012412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156009PMC
September 2018
44 Reads

ISMP Adverse Drug Reactions: Adalimumab-Induced Aseptic Meningitis Pill Desiccant -Induced Acute Hypoxic Respiratory Failure Rivastigmine Patch -Induced Angioedema Acute Liver Failure Due to Etodolac Severe Cognitive Impairment Due to High Free Valproic Acid Levels.

Hosp Pharm 2018 Oct 18;53(5):292-295. Epub 2018 Aug 18.

Temple University School of Pharmacy, Philadelphia, PA, USA.

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of revention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-ßDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with ur readers. E-mail Dr. Read More

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http://dx.doi.org/10.1177/0018578718794518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130117PMC
October 2018
12 Reads

Utility of Clinical and Laboratory Decision Rules in Identifying Bacterial Meningitis Among Children With suspicion of Central Nervous System Infections in a Malaria-Endemic Area, Mbarara Uganda.

Pediatr Infect Dis J 2018 Sep 7. Epub 2018 Sep 7.

Several decision rules combining clinical and biological parameters have been proposed to distinguish bacterial from aseptic meningitis, but have not been evaluated in Africa. In children hospitalized with suspected central nervous system infections in Uganda, we found that the Bacterial Meningitis Score and Meningitest showed lower performance than in European children, and that a decision rule designed specifically using parameters associated with bacterial meningitis also showed inadequate diagnostic performance for clinical use. Read More

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http://dx.doi.org/10.1097/INF.0000000000002185DOI Listing
September 2018
8 Reads