45,991 results match your criteria Ascites


Ascites in the "TAFRO" Syndrome: Does the Squeeze Make the Juice?

Dig Dis Sci 2020 Jul 2. Epub 2020 Jul 2.

Division of Gastroenterology and Hepatology, University of New Mexico, MSC 10-5550, Albuquerque, NM, 87131, USA.

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http://dx.doi.org/10.1007/s10620-020-06433-wDOI Listing

Balloon atrial septostomy and transition of subcutaneous to intravenous prostacyclin infusion for rescuing advanced right heart failure in idiopathic pulmonary arterial hypertension: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-5. Epub 2020 May 3.

Cardiovascular Center, Taichung Veterans General Hospital, No. 1650. Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan.

Background: Intravenous (IV) prostacyclin analogues infusion and balloon atrial septostomy (BAS) are two important treatment options for managing advanced right heart failure in patients with idiopathic pulmonary arterial hypertension (IPAH). References and protocols are rare for dose titrations and transitions between subcutaneous and IV prostacyclin in functional Class IV IPAH patients. Balloon atrial septostomy is rarely done in very few expert centres. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319844PMC

Diagnosing Primary Sclerosing Cholangitis in Children.

Cureus 2020 May 28;12(5):e8334. Epub 2020 May 28.

Radiology, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK.

Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease in children caused by chronic inflammatory process affecting either intrahepatic or extrahepatic bile ducts. Although it is infrequent, incidence is increasing worldwide, may be due to more awareness, understanding and expertise in managing children with chronic liver disease (CLD). In the developing world like Pakistan where resources and expertise are limited, very few tertiary centers are equipped to manage CLD in children. Read More

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http://dx.doi.org/10.7759/cureus.8334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325345PMC

Significant improvement in portal-systemic liver failure symptoms and successful management of portal-splenic venous hemodynamics by the combination of interventional radiology and pharmacotherapy.

Hepatol Res 2020 Jul 1. Epub 2020 Jul 1.

Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube-Yamaguchi, 7558505, Japan.

Aim: To describe a case of hepatitis C virus-related decompensated cirrhosis with portal-systemic liver failure and refractory encephalopathy that was successfully managed with a combination of interventional radiology and pharmacotherapy to improve hepatic function including hyperammonemia and to control portal-splenic venous hemodynamics with hepatic venous pressure gradient (HVPG) monitoring.

Case Presentation: A man in his late 50s presented with a Child-Pugh score of 13, Model for End-Stage Liver Disease-sodium (MELD-Na) score of 19, and blood ammonia level of 185 μg/dL. He underwent balloon-occluded retrograde transvenous obliteration (BRTO) followed by partial splenic embolization (PSE) and non-selective beta-blocker (NSBB) administration. Read More

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http://dx.doi.org/10.1111/hepr.13545DOI Listing

Natural bioactive 4-Hydroxyisophthalic acid (4-HIPA) exhibited antiproliferative potential by upregulating apoptotic markers in in vitro and in vivo cancer models.

Mol Biol Rep 2020 Jun 30. Epub 2020 Jun 30.

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University College Station, College Station, TX, USA.

There is tremendous scope for identifying novel anti-cancer molecules from the unexplored reserves of plant kingdom. The application of dietary supplementation or medicine derived from such sources is a promising approach towards treatment of cancer. In the present study we have evaluated the antiproliferative potential of 4-hydroxyisophthalic acid (4-HIPA), which is a novel antioxidant compound isolated from the roots of the aqueous extract of Decalepis hamiltonii. Read More

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http://dx.doi.org/10.1007/s11033-020-05617-xDOI Listing
June 2020
2.024 Impact Factor

Pleural Effusion Associated with Anicteric Hepatitis A Virus Infection - Unusual Manifestation of a Common Disease: A Case Report.

Pediatric Health Med Ther 2020 16;11:189-192. Epub 2020 Jun 16.

Department of Pediatrics and Child Health, College of Health Sciences, Mekelle University, Tigray, Ethiopia.

Background: Hepatitis A infection is common in children and often presents with mild hepatic disease. The clinical manifestations of hepatitis A virus are usually related to liver damage but sometimes extrahepatic manifestations may occur.

Case Presentation: We present a case of four-year- and eight-month-old male child with anicteric hepatitis A infection associated with a pleural effusion. Read More

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http://dx.doi.org/10.2147/PHMT.S251393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305842PMC

PSAT1 Regulated Oxidation-Reduction Balance Affects the Growth and Prognosis of Epithelial Ovarian Cancer.

Onco Targets Ther 2020 11;13:5443-5453. Epub 2020 Jun 11.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, People's Republic of China.

Introduction: A growing number of studies have found that the serine-glycine biosynthesis pathway is highly activated for biosynthesis in cancer progression and metastasis. Phosphoserine aminotransferase 1 (PSAT1) catalyzes the second step of the serine-glycine biosynthesis pathway; the effects and mechanism of PSAT1 in epithelial ovarian cancer (EOC) remains unclear.

Materials And Methods: The expression of PSAT1 in clinical EOC samples and normal ovarian tissues was conducted by RT-PCR, Western blot, and immunohistochemical staining. Read More

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http://dx.doi.org/10.2147/OTT.S250066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295540PMC

[Unsolved issues of pregnancy in liver cirrhosis].

Ter Arkh 2019 Apr 15;91(4):114-117. Epub 2019 Apr 15.

Obstetric Clinic, University Hospital "Dr. Georgi Stranski", Department of obstetrics and gynecology, Medical University.

Pregnancy in patients with liver cirrhosis and portal hypertension occurs very rare, because of their significantly derailed reproductive functions. Тhe risks for the mother and the fetus are connected with worsening of the portal hypertension, progression of decompensated liver cirrhosis and development of its complications: liver failure, ascites, hepatorenal syndrome, hepatic encephalopathy and variceal hemorrhage, and with increased incidence of spontaneous abortions and abnormal uterine bleeding. The decision for continuation of the pregnancy in cirrhotic patients must be based on individual approach and a multidisciplinary team consisting of obstetricians, hepatologists, anesthesiologists, surgeons and hematologists must participate in the therapy. Read More

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http://dx.doi.org/10.26442/00403660.2019.04.000145DOI Listing

3-Bromopyruvate ameliorates pulmonary arterial hypertension by improving mitochondrial metabolism.

Life Sci 2020 Jun 27:118009. Epub 2020 Jun 27.

Department of Cardiovascular Medicine, The Affiliated Zhuzhou Hospital Xiangya Medical College, Central South University, Zhuzhou, Hunan 412000, China.

Aims: Abnormal mitochondrial metabolism is an essential factor for excessive proliferation of pulmonary artery smooth muscle cells (PASMCs), which drives the pathological process of pulmonary arterial hypertension (PAH). 3-Bromopyruvate (3-BrPA) is an effective glycolytic inhibitor that improves mitochondrial metabolism, thereby repressing anomalous cell proliferation.

Main Methods: An experimental PAH model was established by injection of monocrotaline (MCT) in male Sprague Dawley rats, following which rats were assigned to three groups: control, MCT, and 3-BrPA groups. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118009DOI Listing

Diagnostic utility of oxidative and non-oxidative markers for spontaneous bacterial peritonitis in non-malign ascites.

Acta Gastroenterol Belg 2020 Apr-Jun;83(2):279-284

Ahi Evran University, Department of Biochemistry, Kirsehir, Turkey.

Objective: In this study, we aimed to investigate the diagnostic availability of oxidant and antioxidant parameters in ascites for spontaneous bacterial peritonitis (SBP).

Material And Methods: This study was carried out between July and October 2018 with 25 patients with SBP and 24 patients without SBP. Patients with acute infection, those taking vitamin supplements and antioxidant medication, smoking and drinking alcohol, and patients without ascites culture were excluded from the study. Read More

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Balloon Retrograde Transvenous Obliteration for Treatment of Persistent Gastric Variceal Bleed in Patient With Hepatocellular Carcinoma.

Cureus 2020 Jun 24;12(6):e8796. Epub 2020 Jun 24.

Internal Medicine, University of Connecticut Health Center, Farmington, USA.

Gastric varices are often associated with formation of spontaneous portosystemic shunts that arise to relieve portal hypertension. Balloon retrograde transvenous obliteration (BRTO) is a procedure indicated to prevent recurrent gastric variceal bleeding. Its advantage is diverting blood flow towards the liver, but this can also worsen portal pressure and increase risk for ascites or esophageal variceal bleeding. Read More

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http://dx.doi.org/10.7759/cureus.8796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317128PMC

Closed Incision Negative Pressure Therapy Achieves Better Outcome Than Standard Wound Care: Clinical Outcome and Cost-Effectiveness Analysis in Open Ventral Hernia Repair With Synthetic Mesh Positioning.

Cureus 2020 May 26;12(5):e8283. Epub 2020 May 26.

Surgical, Oncological and Oral Sciences, Policlinico Universitario P. Giaccone, University of Palermo, Palermo, ITA.

Background Surgical site infections (SSIs) and surgical site occurrences (SSOs) are frequent post-operative complications that are dependent on the presence of different risk factors. The use of closed incision negative pressure therapy (ciNPT) is considered a measure by the WHO guidelines for prevention of SSIs. The prevention of SSOs is an extremely important issue in the ventral hernia repair (VHR) surgical field. Read More

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http://dx.doi.org/10.7759/cureus.8283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317132PMC

Multiple myeloma with hepatic amyloid light-chain amyloidosis manifesting as progressive liver failure.

BMJ Case Rep 2020 Jun 29;13(6). Epub 2020 Jun 29.

Pathology, University of Florida Health at Jacksonville, Jacksonville, Florida, USA.

We present a case of a 45-year-old man admitted to the hospital with new-onset ascites and bilateral subconjunctival haemorrhages. He was found to have elevated liver enzymes in a hepatocellular pattern and direct hyperbilirubinemia. A diagnostic paracentesis was consistent with portal hypertension (PH). Read More

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http://dx.doi.org/10.1136/bcr-2020-234637DOI Listing

Therapeutic effect of portal vein stenting for portal vein stenosis after upper-abdominal surgery.

HPB (Oxford) 2020 Jun 27. Epub 2020 Jun 27.

Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address:

Background: The therapeutic effect of portal vein (PV) stenting for PV stenosis following nontransplant hepato-pancreato-biliary (HPB) surgery has not been fully investigated.

Methods: Changes in portal venous pressure (PVP) gradient before and after stenting, complications, symptomatic improvement, and stent patency were evaluated.

Results: We identified 14 consecutive patients undergoing PV stenting for malignant (n = 8) and benign (n = 6) PV stenosis. Read More

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http://dx.doi.org/10.1016/j.hpb.2020.06.003DOI Listing

Pericardectomy after pericarditis constrictiva led to onset of transplant kidney function after 98 days of anuric kidney graft: a case report.

BMC Nephrol 2020 Jun 29;21(1):241. Epub 2020 Jun 29.

Department of Nephrology and Hypertension, University Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Germany.

Background: Constrictive pericarditis is easily overlooked and can lead to severe problems in hemodynamics and end-organ perfusion, in our patient leading to 98 days of anuria after living kidney transplantation. This was completely reversible after pericardectomy.

Case Presentation: A 43-year-old female caucasian patient received a living kidney donation from her mother. Read More

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http://dx.doi.org/10.1186/s12882-020-01899-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324971PMC

[Some practical issues in the management of patients with decompensated liver cirrhosis].

Ter Arkh 2019 Aug 15;91(8):148-154. Epub 2019 Aug 15.

Sechenov First Moscow State Medical University (Sechenov University).

The natural course of cirrhosis is characterized by a shift from a compensated stage without clinical manifestations to a subsequent decompensated stage, which is characterized by the development of obvious clinical symptoms, the most frequent of which are ascites, bleeding from varicose veins, bacterial infections, encephalopathy. The articles and reviews of recent years emphasize the importance of etiotropic treatment of liver cirrhosis at any stage, including the final one. In addition, pathogenetic and symptomatic therapy aimed at treating complications of cirrhosis of the liver: ascites, dilution hyponatremia, gastrointestinal bleeding, bacterial infections, and kidney damage comes to the forefront at the stage of decompensation, which allows the patient to be on the waiting list for liver transplantation. Read More

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http://dx.doi.org/10.26442/00403660.2019.08.000391DOI Listing

[The long-term prospective study of patients with liver cirrhosis after elimination of the hepatitis C virus].

Ter Arkh 2020 Apr 27;92(2):34-42. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

Aim: To study liver function and portal hypertension, incidence and risk factors of liver-related complications, including hepatocellular carcinoma (HCC), in patients with HCV-related liver cirrhosis achieved sustained virologic response (SVR) after direct-acting antiviral therapy.

Materials And Methods: Patients with HCV-related liver cirrhosis were followed up after achievement SVR with assessment of liver function parameters, portal hypertension, Model for End-stage Liver Disease (MELD) and Сhild Pugh (CP) scores, complications development, including HCC, every 36 months. The median follow-up duration was 24 [18; 30] months after end of treatment. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000511DOI Listing

[A clinical case of visceral toxocariasis as a cause of eosinophilic polyserositis].

Ter Arkh 2019 Nov 15;91(11):66-71. Epub 2019 Nov 15.

Nesterov Department of Faculty Therapy Pirogov Russian National Research Medical University.

The aim of the present report is to describe a clinical case of toxocariasis. 37-year - old man was admitted to Pirogov Municipal Clinical Hospital No.1 in Moscow. Read More

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http://dx.doi.org/10.26442/00403660.2019.11.000314DOI Listing
November 2019

Ovarian Cells Have Increased Proliferation in Response to Heparin-Binding Epidermal Growth Factor as Collagen Density Increases.

Tissue Eng Part A 2020 Jun 25. Epub 2020 Jun 25.

Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, Wisconsin, USA.

It is well known that during ovarian cancer progression, the omentum transforms from a thin lacy organ to a thick tougher tissue. However, the mechanisms regulating this transformation and the implications of the altered microenvironment on ovarian cancer progression remain unclear. To address these questions, the global and local concentrations of collagen I were determined for normal and metastatic human omentum. Read More

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http://dx.doi.org/10.1089/ten.tea.2020.0001DOI Listing

Disseminated Leishmaniasis Due to Using Immunosuppression Drugs: A Case Report.

Iran J Parasitol 2020 Apr-Jun;15(2):278-281

Pediatric's Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Visceral leishmaniasis is a common parasitic disease between humans and animals, transmitted by sandflies () in the Mediterranean countries, including Iran. The statistics have been reported less than real due to errors in the diagnosis and reporting of affected cases. In this report, we will present the symptoms and manifestations of this disease to reduce late detection and exacerbating factors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311812PMC

Cytomorphology of Mycobacterium avium intracellulare-associated ascites.

Diagn Cytopathol 2020 Jun 27. Epub 2020 Jun 27.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Ascites due to Mycobacterium avium intracellulare (MAI) infection is extremely rare and associated with a poor outcome. The cytomorphology of this condition has not been previously reported. We present a unique case of a 45-year-old woman with iatrogenic immunodeficiency who developed MAI-associated chylous ascites. Read More

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http://dx.doi.org/10.1002/dc.24532DOI Listing

Surgical intervention for portal hypertension caused by oxaliplatin-based chemotherapy: a case report and a review of literature regarding radiological and/or surgical interventions for oxaliplatin-associated portal hypertension.

Clin J Gastroenterol 2020 Jun 26. Epub 2020 Jun 26.

Department of Surgery, Yokohama Ekisaikai Hospital, 1-2 Yamada-cho, Naka-ku, Yokohama, 231-0036, Japan.

A 63-year-old man showed massive ascites, massive pleural effusion, severe lower-extremity edema, and repeated esophageal variceal bleeding. Two-year previously, he received 13-courses of oxaliplatin-based chemotherapy (OBC) followed by associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for multiple colorectal cancer liver metastases but developed a solitary remaining liver metastasis and multiple lung metastases 2 months after the ALPPS, for which multiple regimens of chemotherapy were conducted. The symptoms were considered attributable to the OBC-associated portal-hypertension. Read More

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http://dx.doi.org/10.1007/s12328-020-01157-wDOI Listing

Ruptured Degenerating Fibroid Causing Preterm Labour and Systemic Inflammatory Response Syndrome.

J Obstet Gynaecol Can 2020 Jul;42(7):903-905

Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON; Sunnybrook Health Sciences Centre, Toronto, ON.

Background: Fibroids are present in at least 10% of pregnancies and are recognized to cause a variety of complications. A few case reports have described fibroids as an etiological factor in uterine rupture, sometimes with life-threatening hemorrhage.

Case: A 28-year-old G1, P0 woman at 20 weeks gestation developed systemic inflammatory response syndrome with acute renal failure and massive ascites secondary to a ruptured degenerated fibroid. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.09.007DOI Listing

Microenvironment remodeled by tumor and stromal cells elevates fibroblast-derived COL1A1 and facilitates ovarian cancer metastasis.

Exp Cell Res 2020 Jun 23:112153. Epub 2020 Jun 23.

Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China. Electronic address:

Wide peritoneal metastasis is the cause of the highest lethality of ovarian cancer in gynecologic malignancies. Ascites play a key role in ovarian cancer metastasis, but involved mechanism is uncertain. Here, we performed a quantitative proteomics of ascites, and found that collagen type I alpha 1 (COL1A1) was notably elevated in ascites from epithelial ovarian cancer patients compared to normal peritoneal fluids, and verified that elevated COL1A1 was mainly originated from fibroblasts. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112153DOI Listing

Transjugular intrahepatic portosystemic shunt and alfapump® system for refractory ascites in liver cirrhosis: Outcomes and complications.

United European Gastroenterol J 2020 Jun 26:2050640620938525. Epub 2020 Jun 26.

Hepatology, University Clinic for Visceral Surgery and Medicine, Bern, Switzerland.

Background: Treatment of refractory ascites in liver cirrhosis is challenging. Transjugular intrahepatic portosystemic shunt and alfapump® have been proposed for the management, but few data comparing both exist.

Aims: The aim of this study was to evaluate the characteristics and outcomes of patients treated with transjugular intrahepatic portosystemic shunt and alfapump® for refractory ascites at our centre. Read More

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http://dx.doi.org/10.1177/2050640620938525DOI Listing

Post-mortem Diagnosis of Heme Oxygenase-1 Deficiency by Whole Exome Sequencing in an Iranian Child.

Int J Mol Cell Med 2019 ;8(4):300-307

Department of Pediatrics, Tehran University of Medical Sciences,Tehran, Iran.

Heme oxygenase-1 (HO-1) is an inducible enzyme involved in the catalysis of heme conversion into biliverdin. We describe a patient with a novel stop-gain mutation in the coding sequence resulting in HO-1 deficiency. A 17-month-old female with fever, tachypnea, and signs of respiratory distress was referred to our center. Read More

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http://dx.doi.org/10.22088/IJMCM.BUMS.8.4.300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305464PMC
January 2019

Management of ventriculo-gallbladder shunt in the presence of gallstones.

BMJ Case Rep 2020 Jun 24;13(6). Epub 2020 Jun 24.

Department of Pediatric Neurosurgery, National Guard Health Affairs, Riyadh, Saudi Arabia.

Hydrocephalus is a prevalent health problem that is frequently encountered by paediatric neurosurgeons during infancy and childhood. We report a case of an 11-year-old boy with high cerebrospinal fluid protein hydrocephalus secondary to optic glioma that required a ventriculoperitoneal (VP) shunt. The patient had multiple failures of VP shunt and developed massive ascites. Read More

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http://dx.doi.org/10.1136/bcr-2020-234775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319722PMC

Safety and feasibility of transjugular intrahepatic portosystemic shunt in elderly patients with liver cirrhosis and refractory ascites.

PLoS One 2020 25;15(6):e0235199. Epub 2020 Jun 25.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

Background & Aims: The management of patients with refractory ascites (RA) is challenging, particularly at higher age. Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment for RA, but safety data in elderly patients are rare. Our aim was to evaluate the safety and feasibility of TIPS in elderly patients with RA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235199PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316253PMC

Change in Patient MELD-Na and Albumin Level From the Time of Celiac Disease Diagnosis to Six Months Later After Gluten-Free Diet.

Cureus 2020 May 22;12(5):e8237. Epub 2020 May 22.

Biostatistics, Geisinger Medical Center, Danville, USA.

Background & aims Celiac disease (CD) is a multisystem disorder triggered by dietary gluten in genetically predisposed individuals that may affect any organ system, including the liver. We evaluated a change in patient model for end-stage liver disease (MELD)-Na and albumin level from the time of celiac disease diagnosis to six months later, after implementing a gluten-free diet. Methods A retrospective study was conducted from January 1, 2006, to June 30, 2018. Read More

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http://dx.doi.org/10.7759/cureus.8237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306642PMC

Early-TIPS Versus Current Standard Therapy for Acute Variceal Bleeding in Cirrhosis Patients: A Systemic Review With Meta-analysis.

Front Pharmacol 2020 20;11:603. Epub 2020 May 20.

Department of Obstetrical, Jining No.1 People's Hospital, Jining, China.

Background: The survival of early placement (within 72h after admission) of transjugular intrahepatic portosystemic shunts (early-TIPS) in patients with cirrhosis and acute variceal bleeding (AVB) is controversial.

Objectives: We performed a systemic review and meta-analysis to assess whether early-TIPS could improve survival in patients with cirrhosis and acute variceal bleeding.

Methods: A systematic search of the literature was conducted in PubMed, EMBASE, and Cochrane Library published before 25 June 2019 for eligible studies that compared early-TIPS with a combination of endoscopic variceal ligation (EVL) and pharmacotherapy in the therapeutic effect in AVB patients. Read More

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http://dx.doi.org/10.3389/fphar.2020.00603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282546PMC

Is cell block technique useful to predict histological type in patients with ovarian mass and/or body cavity fluids?

Nagoya J Med Sci 2020 May;82(2):225-235

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

The cell block (CB) technique is a generalized method utilized for the diagnostic evaluation of body cavity fluids. Ascites cytology is one of the most important diagnostic processes for epithelial ovarian cancer. However, in clinical practice, the usefulness of the CB method to diagnose this tumor remains unelucidated. Read More

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http://dx.doi.org/10.18999/nagjms.82.2.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276405PMC

Malignant Peritoneal Mesothelioma Presenting with Polymyalgia Rheumatica-like Syndrome.

Intern Med 2020 Jun 23. Epub 2020 Jun 23.

Department of Clinical Laboratory, Hiroshima-Nishi Medical Center, Japan.

A 30-year-old man was admitted to our hospital because of pain in his proximal extremities. The pain mimicked polymyalgia rheumatica (PMR) and it temporarily improved by a low dose of glucocorticoids, but his symptoms relapsed many times. After six years of glucocorticoid treatment, he developed abdominal pain and ascites, for which he was diagnosed with malignant peritoneal mesothelioma (MPM). Read More

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http://dx.doi.org/10.2169/internalmedicine.4809-20DOI Listing

HIST1H2BB and MAGI2 methylation and somatic mutations as precision medicine biomarkers for diagnosis and prognosis of high-grade serous ovarian cancer.

Cancer Prev Res (Phila) 2020 Jun 24. Epub 2020 Jun 24.

University of Puerto Rico School of Medicine

Molecular alterations that contribute to long-term (LT) and short-term (ST) survival in ovarian High-Grade Serous Carcinoma (HGSC) may be used as precision medicine biomarkers. DNA promoter methylation is an early event in tumorigenesis, which can be detected in blood and urine, making it a feasible companion biomarker to somatic mutations for early detection and targeted treatment workflows. We compared the methylation profile in 12 high-grade serous ovarian cancer (HGSC) tissue samples to 30 fallopian tube epithelium samples, using the Infinium Human Methylation 450K Array. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-19-0412DOI Listing

Elective Abdominal Aortic Aneurysm Repair Complicated with Chylous Ascites.

Authors:
Zia Ur Rehman

J Coll Physicians Surg Pak 2020 May;30(5):557-558

Department of Surgery, The Aga Khan University Hospital, Karachi, Pakistan.

Null. Read More

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http://dx.doi.org/10.29271/jcpsp.2020.05.557DOI Listing
May 2020
0.318 Impact Factor

Improvement in Quality of Life and Decrease in Large-Volume Paracentesis Requirements With the Automated Low-Flow Ascites Pump.

Liver Transpl 2020 Jun 24. Epub 2020 Jun 24.

BGS Gleneagles Hospital, Kengeri, Bengaluru, 56070, Karnataka, India.

We read with great interest the multicenter, open-label study of the Alfa pump system in cirrhosis with recurrent ascites (MOSAIC study) by wong et al in which they have described safety and efficacy of automated low flow ascitic (ALFA) pump system for control of refractory ascites in north American cohort (1).In this study ALFA pump system insertion by interventional radiologist using a minimally invasive technique yield similar technical success as compared to surgical insertion techniques in previous studies. Read More

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http://dx.doi.org/10.1002/lt.25827DOI Listing

Differential expression of Bax-Bcl-2 and PARP-1 confirms apoptosis of EAC cells in Swiss albino mice by Morus laevigata.

J Food Biochem 2020 Jun 24:e13342. Epub 2020 Jun 24.

Molecular Biology and Protein Science Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh.

A safer natural alternative to treat neoplastic cells by inducing apoptosis is a prime requisite. Therefore, the current study was to evaluate the antiproliferative activity of Morus laevigata, a wild-type Mulberry species. Antioxidant and cytotoxic activity of aqueous extracts of M. Read More

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http://dx.doi.org/10.1111/jfbc.13342DOI Listing

Magnetic resonance imaging findings of extrauterine high-grade serous carcinoma based on new pathologic criteria for primary site assignment.

Acta Radiol 2020 Jun 23:284185120934474. Epub 2020 Jun 23.

Department of Radiology, Gifu University, Gifu, Japan.

Background: There has been no study that has reported magnetic resonance imaging (MRI) findings of extrauterine high-grade serous carcinomas (HGSCs) that have been histologically determined by the new criteria.

Purpose: To assess MRI findings of extrauterine HGSCs based on new pathologic criteria.

Material And Methods: Fifty patients with histopathologically proven extrauterine HGSCs, who underwent pretreatment gadolinium-enhanced MRI, were included in this study. Read More

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http://dx.doi.org/10.1177/0284185120934474DOI Listing

Fetal Meconium Peritonitis - Prenatal Findings and Postnatal Outcome: A Case Series, Systematic Review, and Meta-Analysis.

Ultraschall Med 2020 Jun 23. Epub 2020 Jun 23.

Prenatal Diagnosis and Medical Genetics Program, Mount Sinai Hospital Sidney Liswood Health Sciences Library, Toronto, Canada.

Purpose:  To describe the postnatal outcome of fetal meconium peritonitis and identify prenatal predictors of neonatal surgery.

Methods:  We retrospectively reviewed all fetuses with ultrasound findings suspicious for meconium peritonitis at a single center over a 10-year period. A systematic review and meta-analysis were then performed pooling our results with previous studies assessing prenatally diagnosed meconium peritonitis and postnatal outcome. Read More

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http://dx.doi.org/10.1055/a-1194-4363DOI Listing

Role of Terlipressin and Albumin for Hepatorenal Syndrome in Liver Transplantation.

Liver Transpl 2020 Jun 23. Epub 2020 Jun 23.

Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY, USA.

Hepatorenal syndrome is one of the most ominous complications of portal hypertension in patients with decompensated cirrhosis and ascites. It is associated with very high mortality on the waiting list. Liver transplantation is the most successful therapeutic option for patients with hepatorenal syndrome. Read More

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http://dx.doi.org/10.1002/lt.25834DOI Listing

Improving performance of recently introduced flow cytometry-based approach of malignant cell screening in serous cavity effusion.

Int J Lab Hematol 2020 Jun 23. Epub 2020 Jun 23.

Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Introduction: Microscopy has been recognized as the "gold-standard" cellular analysis of serous cavity effusion. However, this method is time-consuming, labor-intensive, and requires accomplished skills. Here, we investigated the efficiency of hematology analyzer in screening malignant cells in serous cavity effusion. Read More

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http://dx.doi.org/10.1111/ijlh.13269DOI Listing

MELD remains the best predictor of mortality in outpatients with cirrhosis and severe ascites.

Aliment Pharmacol Ther 2020 Jun 23. Epub 2020 Jun 23.

Liver Failure Group, Institute for Liver and Digestive Health, University College London, London, UK.

Background: The Model for Endstage Liver Disease (MELD) score may put patients with severe ascites at a disadvantage because they often have a poor quality of life and high mortality despite a favourable MELD score.

Aim: To develop a model that is better than the MELD score at predicting 1-year mortality among patients with cirrhosis, severe ascites and MELD ≤18.

Methods: We used data from a randomised trial (SPARe-1) of patients with cirrhosis and severe ascites to develop a model to predict 1-year mortality. Read More

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http://dx.doi.org/10.1111/apt.15882DOI Listing

Primary robotic retroperitoneal lymph node dissection following orchiectomy for testicular germ cell tumors: a single-surgeon experience.

J Robot Surg 2020 Jun 22. Epub 2020 Jun 22.

The James Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

The objectives were to evaluate the safety and oncologic efficacy of primary robotic retroperitoneal lymph node (R-RPLND) dissection for testicular germ cell tumors. A retrospective analysis was performed on all primary R-RPLND cases performed by a single surgeon, who performs both open and R-RPLND at a high-volume academic institution, between August 2013 and August 2019. Data on patient demographics, operative techniques, perioperative outcomes, and tumor characteristics were obtained. Read More

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http://dx.doi.org/10.1007/s11701-020-01107-1DOI Listing

A single-cell landscape of high-grade serous ovarian cancer.

Nat Med 2020 Jun 22. Epub 2020 Jun 22.

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor prognosis. To comprehensively characterize the HGSOC ascites ecosystem, we used single-cell RNA sequencing to profile ~11,000 cells from 22 ascites specimens from 11 patients with HGSOC. We found significant inter-patient variability in the composition and functional programs of ascites cells, including immunomodulatory fibroblast sub-populations and dichotomous macrophage populations. Read More

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http://dx.doi.org/10.1038/s41591-020-0926-0DOI Listing

Primed circulating monocytes are a source of IL-1β in patients with cirrhosis and ascites.

Gut 2020 Jun 22. Epub 2020 Jun 22.

Department of Medicine III, University Hospital Aachen, Aachen, Germany

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http://dx.doi.org/10.1136/gutjnl-2020-321597DOI Listing
June 2020
14.660 Impact Factor

Glucocorticoid versus traditional therapy for hepatitis B virus-related acute-on-chronic liver failure: A systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(25):e20604

Infectious Disease Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

Objective: This meta-analysis aimed to assess the efficacy and safety of glucocorticoid versus traditional therapy for hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF).

Methods: PubMed, Cochrane Central Register of Clinical Trials, and EMBASE were searched. All clinical studies, including randomized controlled studies and cohort studies, comparing glucocorticoids with traditional treatments (until November 1, 2018), were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000020604DOI Listing
June 2020
5.723 Impact Factor

Gamma Radiation-Attenuated Provokes Apoptosis in Ehrlich Ascites Carcinoma-Bearing Mice Generating Long-Lasting Immunity.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820926593

Radiation Biology Department, National Center for Radiation Research and Technology, Atomic Energy authority, Cairo, Egypt.

Purpose: Pathological angiogenesis and apoptosis evasions are common hallmarks of cancer. A different approach to the antitumor effect of parasitic diseases caused by certain protozoans and helminthes had been adopted in recent years as they can affect many cancer characteristics. The present work is an attempt to assess the effect of gamma radiation-attenuated ME49 as an antiapoptotic and angiogenic regulator modifier on tumor growth aimed at improving cancer protective protocols. Read More

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http://dx.doi.org/10.1177/1533033820926593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309383PMC

Edible Sword Bean Extract Induces Apoptosis in Cancer Cells In Vitro and Inhibits Ascites and Solid Tumor Development In Vivo.

Nutr Cancer 2020 Jun 22:1-11. Epub 2020 Jun 22.

Laboratory of Immunopharmacology and Experimental Therapeutics, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Antitumor potential of edible sword bean ( (L.)) extract has been evaluated against Daltons lymphoma ascites (DLA) using in vitro and in vivo studies. Methanolic extraction was carried out and in vitro studies were performed against both DLA and A549, lung cancer cell lines. Read More

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http://dx.doi.org/10.1080/01635581.2020.1781202DOI Listing

Factors Associated with Prolonged Recipient Hepatectomy Time During Liver Transplantation: A Single-Centre Experience.

World J Surg 2020 Jun 22. Epub 2020 Jun 22.

HPB and Liver Transplant Unit, Department of General and Digestive Surgery, Hospital Clínic, IDIBAPS, CIBEREHD, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain.

Background: Recipient hepatectomy during liver transplantation can be a challenging operation and can increase cold ischaemic time. The aim of this study is to assess factors associated with prolonged recipient hepatectomy.

Methods: From 2005 to 2015, 930 patients were submitted to liver transplantation in our hospital. Read More

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http://dx.doi.org/10.1007/s00268-020-05643-7DOI Listing

H-NMR spectroscopy metabonomics of reactive, ovarian carcinoma and hepatocellular carcinoma ascites.

Pleura Peritoneum 2020 Jun 12;5(2):20200113. Epub 2020 May 12.

Department of Medicine, University of Padova School of Medicine and Surgery, Padova, Italy.

Background: Metabolomic profiling of human malignant effusion remain a field poorly investigated. Proton nuclear magnetic resonance (H-NMR) spectroscopy is a rapid relatively low cost technique, and effusion is an optimal biospecimen suitable for metabonomic investigations. With this study we addressed metabolomic profiling of malignant ascitic effusion (mAE) from patients with high grade serous ovarian carcinoma (HGSOC), Hepatocellular carcinoma (HCC), and benign AEs (bAEs) from patients with reactive peritonitis. Read More

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http://dx.doi.org/10.1515/pp-2020-0113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292235PMC