44,348 results match your criteria Ascites


NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis - Correlations with Disease Severity.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

determined. Liver disease severity in patients with cirrhosis was established by Child-Pugh class, MELD score and presence/absence of ascites. Results: Plasma levels of NT-proBNP were significantly higher in cirrhotic patients than in the healthy subjects. Read More

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http://dx.doi.org/10.1159/000499930DOI Listing

SGLT2 inhibitors and cirrhosis: A unique perspective on the comanagement of diabetes mellitus and ascites.

Clin Liver Dis (Hoboken) 2018 Jun 26;11(6):141-144. Epub 2018 Jul 26.

Section of Digestive Diseases Yale University School of Medicine New Haven CT.

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http://dx.doi.org/10.1002/cld.714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385962PMC

CON ("The window is closed"): In patients with cirrhosis with ascites, the clinical risks of nonselective beta-blocker outweigh the benefits and should NOT be prescribed.

Clin Liver Dis (Hoboken) 2018 May 5;11(5):123-127. Epub 2018 Jun 5.

Department of Internal Medicine, Division of Digestive and Liver Diseases UT Southwestern Medical Center Dallas TX.

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http://dx.doi.org/10.1002/cld.699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385953PMC

PRO ("The Window Is Open"): In patients with cirrhosis with prior variceal hemorrhage and ascites, the clinical benefits of nonselective beta-blockers outweigh the risks and should be prescribed.

Clin Liver Dis (Hoboken) 2018 May 5;11(5):119-122. Epub 2018 Jun 5.

Recanati/Miller Transplantation Institute, Division of Liver Diseases Mount Sinai Medical Center New York NY.

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http://dx.doi.org/10.1002/cld.700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385954PMC

Early experiences with the use of continuous erector spinae plane blockade for the provision of perioperative analgesia for pediatric liver transplant recipients.

Reg Anesth Pain Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology - Division of Pediatric Anesthesiology, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA.

Objective: Pediatric liver transplantation presents a number of anesthetic challenges, especially in providing adequate perioperative analgesia. In an effort to reduce opioid consumption and improve functional outcomes following pediatric liver transplantation, we have instituted a novel analgesia protocol centered on the provision of continuous regional analgesia with erector spinae plane (ESP) blockade.

Cases: We describe preincisional bilateral ESP catheter placement in two pediatric patients undergoing orthotopic liver transplantation. Read More

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http://dx.doi.org/10.1136/rapm-2018-100253DOI Listing

Successful percutaneous embolization of refractory chylous ascites following peritoneal lymph node dissection.

Radiol Case Rep 2019 Jun 30;14(6):708-710. Epub 2019 Mar 30.

Department of Radiology, Madigan Army Medical Center, 9040A Jackson Avenue, Joint Base Lewis-McChord, WA 98431, USA.

Chylous leaks are an uncommon complication in patients undergoing surgical procedures with the majority of cases responding to conservative therapies. Described is a case of a 23-year-old male who developed debilitating refractory chylous ascites as a complication after retroperitoneal lymph node dissection for testicular cancer. Prior to being evaluated by interventional radiology, he required weekly large-volume paracentesis in addition to standard conservative therapies. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446071PMC

Sclerosing encapsulating peritonitis: imaging findings in an uncommon entity.

Radiologia 2019 Apr 12. Epub 2019 Apr 12.

Servicio de Diagnóstico por Imágenes, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating peritonitis, with an emphasis on the computed tomography findings.

Conclusion: The incidence of sclerosing encapsulating peritonitis is low. The pathophysiology of this condition is unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00338338193003
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http://dx.doi.org/10.1016/j.rx.2019.02.005DOI Listing
April 2019
1 Read

[Ascites and Renal Insufficiency in a 25 Year Old Woman].

Dtsch Med Wochenschr 2019 Apr 15;144(8):544-546. Epub 2019 Apr 15.

Abteilung für Tropenmedizin und Infektiologie und Sektion Nephrologie, Zentrum für Innere Medizin II, Universitätsmedizin Rostock.

Clinical Case:  We report of a 25 year old woman who presented with acute dysuria. She had a normal vaginal delivery three months earlier. She developed increasing ascites and laboratory findings were indicative for acute renal failure. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0819-6331
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http://dx.doi.org/10.1055/a-0819-6331DOI Listing
April 2019
1 Read

Acute pancreatitis with abdominal bloating and distension, normal lipase and amylase: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15138

Departments of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, PR China and Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, PR China.

Rationale: Acute pancreatitis is an inflammatory disorder of the pancreas, and its correct diagnosis is an area of interest for clinicians. In accordance with the revised Atlanta classification, acute pancreatitis can be diagnosed if at least 2 of the following 3 criteria are fulfilled: abdominal pain; serum lipase (or amylase) activity at least 3 times the upper limit of normal; or characteristic findings of acute pancreatitis on contrast-enhanced computed tomography (CT) or, less often, magnetic resonance imaging or transabdominal ultrasonography. Diagnostic imaging is essential in patients with no or slight enzyme elevation. Read More

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http://dx.doi.org/10.1097/MD.0000000000015138DOI Listing

Prenatal extravasation of urine seems to preserve renal function in boys with posterior urethral valves.

J Pediatr Urol 2019 Feb 27. Epub 2019 Feb 27.

Oslo University Hospital, Department of Pediatric Surgery, Norway.

Introduction: A posterior urethral valve (PUV) may lead to extravasation of urine, resulting in prenatal ascites and/or perirenal urinoma. Extravasation has been presumed to act as a pop-off mechanism, preserving renal function, but previous reports addressing this presumption have been inconclusive.

Aim Of Study: The present study compares renal function in patients with PUV with and without extravasation. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.02.010DOI Listing
February 2019

Predictive value of hepatic venous pressure gradient for graft hemodynamics in living donor liver transplantation.

Liver Transpl 2019 Apr 13. Epub 2019 Apr 13.

Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH.

Hepatic venous pressure gradient (HVPG) is known to correlate with severity of portal hypertension in patients with liver cirrhosis. This retrospective study investigated the clinical value of preoperative measurement of HVPG in patients who underwent adult-to-adult LDLT and its predictive value for hepatic hemodynamics after graft reperfusion. For this study, seventy-five patients who underwent adult-to-adult LDLT were divided into two groups (HVPG < 16 mmHg or HVPG > 16 mmHg) to investigate the correlation between preoperative HVPG and characteristics and surgical outcomes of the patients, including portal vein flow (PVF) and hepatic artery flow (HAF) after graft reperfusion. Read More

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http://dx.doi.org/10.1002/lt.25471DOI Listing

Vascular syndromes in liver cirrhosis.

Clin J Gastroenterol 2019 Apr 12. Epub 2019 Apr 12.

Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, 19102, USA.

Liver cirrhosis is associated with multiple vascular syndromes affecting almost all body systems. Many of these syndromes are directly related to impaired liver function and sometimes reversible after liver transplantation while others arise secondary to portal hypertension and ascites. Altered expression of angiogenic and vasoactive compounds (most importantly nitric oxide), endothelial dysfunction, dysregulated neurohormonal control, and systemic inflammatory state play differential roles in mediating homeostatic instability and abnormal vasogenic response. Read More

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http://link.springer.com/10.1007/s12328-019-00956-0
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http://dx.doi.org/10.1007/s12328-019-00956-0DOI Listing
April 2019
2 Reads

Design and rationale of a randomized-controlled trial of home-delivered meals for the management of symptomatic ascites: the SALTYFOOD trial.

Gastroenterol Rep (Oxf) 2019 04 11;7(2):146-149. Epub 2019 Mar 11.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Background: When patients with cirrhosis develop ascites, it is associated with sharply increased mortality and healthcare utilization with decreased quality of life. Dietary salt restriction is first-line therapy for ascites but it is limited by poor adherence.

Methods: We will recruit 40 patients with cirrhosis and ascites who have received a recent paracentesis or hospitalization for a 1:1 randomized trial of standard care (education on salt restriction) versus home-delivered meals. Read More

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http://dx.doi.org/10.1093/gastro/goz005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454849PMC
April 2019
1 Read

Ovarian Cancer Immature Teratoma Type in Pregnancy: Management and Feto-Maternal Outcomes.

Open Access Maced J Med Sci 2019 Mar 15;7(6):1016-1020. Epub 2019 Mar 15.

Department of Obstetrics and Gynaecology, Pediatrics, Anatomical Pathology, Medical Science Faculty of Udayana University, Sanglah Hospital, Bali, Indonesia.

Background: Immature teratoma is malignant ovarian germ cell tumours (MOGCTs). The case in pregnancy is very rare which less than 1% of all ovarian teratoma cases. The aim is to reach optimal and comprehensive management for immature ovarian teratoma in pregnancy to gain the healthiest maternal and fetal outcomes. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2019.129
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http://dx.doi.org/10.3889/oamjms.2019.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454180PMC
March 2019
5 Reads

Symptomatic Hyperglycemia in a Patient with Dialysis Ascites.

Am J Med Sci 2019 Feb 27. Epub 2019 Feb 27.

Division of Nephrology, Department of Medicine; Research Service, Raymond G. Murphy VA Medical Center, Albuquerque, New Mexico. Electronic address:

An anuric woman with ascites rapidly developed extreme hyperglycemia and seizures after hemodialysis. During development of hyperglycemia, the decrease in serum sodium concentration (Δ[Na]) was nearly twice the value predicted by a formula accounting for the degree of hyperglycemia and the intracellular-to-extracellular volume ratio. The prediction assumed that ascitic fluid is part of the extracellular volume. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.016DOI Listing
February 2019
1 Read

[Preparation of tiamulin artificial complete antigen and development of its monoclonal antibody].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2019 Feb;35(2):174-179

School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China. *Corresponding author, E-mail:

Objective To develop high-sensitivity and high-specificity monoclonal antibody against tiamulin (TML). Methods Using oximation and carbodiimide method, TML was conjugated to bovine serum albumin (BSA) and ovalbumin (OVA) to prepare the immunogen TML-BSA and coating antigen TML-OVA, respectively. BALB/c mice were immunized with TML-BSA. Read More

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February 2019
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Associations Between Sonographic Findings and Operative Time of Transumbilical Laparoscopic-Assisted Appendectomy for Acute Appendicitis in Children.

AJR Am J Roentgenol 2019 Apr 11:1-9. Epub 2019 Apr 11.

1 Department of Radiology, Saitama Children's Medical Center, Japan.

Objective: The purpose of this study is to evaluate the association between sonographic findings and the operative time of transumbilical laparoscopic-assisted appendectomy (TULAA) for appendicitis in children.

Materials And Methods: We included 131 children who underwent ultrasound within 24 hours before TULAA. We evaluated the associations between operative time and patients' demographics, as well as the following sonographic findings: maximum outer wall diameter of the appendix, appendicolith, ascites (not echogenic), echogenic ascites, abscess formation, increased intraabdominal fat echo in the right lower quadrant (RLQ; 3-point scale), and the location of the appendix (three locations). Read More

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http://dx.doi.org/10.2214/AJR.18.20937DOI Listing
April 2019
4 Reads

A case of ruptured splenic cyst with elevated serum levels of CEA treated by laparoscopic unroofing.

Clin J Gastroenterol 2019 Apr 10. Epub 2019 Apr 10.

Department of Surgery, Japanese Red Cross Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.

Splenic cysts are rare and tend to have elevated tumor markers, of which carbohydrate antigen (CA) 19-9 is the most frequently elevated. Therefore, splenic cysts with elevated serum carcinoembryonic antigen (CEA) levels and without CA19-9 elevation are extremely rare. A 26-year-old woman presented with sudden upper abdominal pain while sleeping. Read More

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http://dx.doi.org/10.1007/s12328-019-00980-0DOI Listing
April 2019
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[Application of CT-based radiomics in differentiating primary gastric lymphoma from Borrmann type IV gastric cancer].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Mar;44(3):257-263

Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Objective: To explore the feasibility of CT-based image radiomics signature in identification of primary gastric lymphoma and Borrmann type IV gastric cancer.
 Methods: A retrospective analysis of 71 patients with primary gastric lymphoma or Borrmann type IV gastric cancer confirmed by pathology in our Hospital from January 2009 to April 2017 was performed. There were 28 patients with primary gastric lymphoma and 43 patients with Borrmann type IV gastric cancer. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.03.005DOI Listing
March 2019
2 Reads

Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma.

Biomed Pharmacother 2019 Apr 27;112:108707. Epub 2019 Feb 27.

Department of Chemistry, Yuvaraja's College (Autonomous), University of Mysore, Mysuru, 570005, Karnataka, India. Electronic address:

The synthesis and antiproliferative effect of a series of quinoline and thiazole containing coumarin analogs 12a-d and 13a-f respectively, on mice leukemic cells was performed. The chemical structures of newly synthesized compounds were confirmed by IR, H NMR, C NMR and mass spectral analysis. The result indicates that, 7-methoxy-2-oxo-2H-chromene-3-carboxylic acid [4-(4-methoxy-phenyl)-thiazol-2-yl]-amide (13f) showed potent activity against EAC and DLA cells in MTT (15. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108707DOI Listing
April 2019
1 Read
2.023 Impact Factor

Albumin in Cirrhosis: More Than a Colloid.

Curr Treat Options Gastroenterol 2019 Apr 9. Epub 2019 Apr 9.

Division of Nephrology (Kidney-Liver Program), Department of Medicine, University of Washington, 356521, 1959 NE Pacific Street, Seattle, WA, 98195-6521, USA.

Purpose Of Review: Albumin has repeatedly been shown to be beneficial in treating patients with decompensated cirrhosis. We reviewed the medical literature regarding indications for the use of intravenous albumin in cirrhosis, with particular focus on the ways in which albumin can help mitigate hepatorenal physiology.

Recent Findings: Albumin has long been used as the preferred agent for volume expansion in patients with decompensated cirrhosis. Read More

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http://dx.doi.org/10.1007/s11938-019-00227-4DOI Listing
April 2019
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A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell Characteristics in Ovarian Cancer.

Cancers (Basel) 2019 Apr 8;11(4). Epub 2019 Apr 8.

Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA.

A small of population of slow cycling and chemo-resistant cells referred to as cancer stem cells (CSC) have been implicated in cancer recurrence. There is emerging interest in developing targeted therapeutics to eradicate CSCs. Aldehyde-dehydrogenase (ALDH) activity was shown to be a functional marker of CSCs in ovarian cancer (OC). Read More

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http://dx.doi.org/10.3390/cancers11040502DOI Listing
April 2019
1 Read

Improvement of hyponatremia in cirrhosis is associated with improved complex information processing.

J Gastroenterol Hepatol 2019 Apr 9. Epub 2019 Apr 9.

Liver Unit, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), and Centro de Investigaciones en Red Hepatologia y Digestivas (CIBEReHD), Barcelona, Spain.

Background And Aim: Hyponatremia, a cause of brain dysfunction and risk factor for hepatic encephalopathy, is frequent in patients with advanced cirrhosis and ascites. The interdependence of liver failure and hyponatremia makes it difficult to separate the effects of each on cognitive function. The objective was to assess whether an increase in plasma sodium in patients with cirrhosis and ascites leads to an improvement in cognitive function. Read More

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http://dx.doi.org/10.1111/jgh.14683DOI Listing
April 2019
1 Read

An extremely severe case of Aicardi-Goutières syndrome 7 with a novel variant in IFIH1.

Eur J Med Genet 2019 Apr 6. Epub 2019 Apr 6.

Division of Neonatology, Center for Maternal-Fetal, Neonatal, and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.

We describe herein an extremely severe case of Aicardi-Goutières syndrome 7 (AGS7). The female patient was the daughter of nonconsanguineous parents and developed cardiomegaly, pericardial effusion, splenomegaly, and intracranial calcification during the fetal period. Because her cardiotocogram showed a non-reassuring fetal status, she was delivered at 29 weeks and 4 days of gestation by an emergency cesarean section. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.04.003DOI Listing
April 2019
1 Read

Ovarian mucinous carcinoma with mural carcinosarcomatous components in a prepubertal girl.

J Pediatr Adolesc Gynecol 2019 Apr 6. Epub 2019 Apr 6.

Department of Obstetrics and Gynecology, Dokkyo Medical University Saitama Medical Center, Koshigaya Japan.

Background: Epithelial ovarian cancer development before menarche is extremely rare.

Case: We report a prepubertal girl who developed ovarian mucinous carcinoma with mural carcinosarcomatous components.

Summary And Conclusion: Magnetic resonance imaging showed a polycystic mass with solid components. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.04.005DOI Listing
April 2019
1 Read
1.812 Impact Factor

Renal Lymphangiectasia in the Transplanted Kidney: Case Series and Literature Review.

Transplantation 2019 Apr 4. Epub 2019 Apr 4.

Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.

Background: Renal lymphangiectasia is a rare and poorly understood lymphatic disease associated with lymphatic dilation and leakage. To our knowledge, no cases have been described in the context of a transplanted kidney.

Methods: We describe two cases of renal lymphangiectasia in transplanted kidneys, both from pediatric donors. Read More

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http://dx.doi.org/10.1097/TP.0000000000002745DOI Listing
April 2019
1 Read

Double-hit pancreatic B-lymphoblastic lymphoma with a variant translocation t(2;18)(p11;q21).

Int J Hematol 2019 Apr 8. Epub 2019 Apr 8.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Double-hit lymphoma is typically categorized as "high-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements", but in infrequent cases in which terminal deoxynucleotidyl transferase (TdT) expression is positive, it is categorized as B-lymphoblastic lymphoma (B-LBL). BCL2 rearrangements are usually caused by t(14;18)(q32;q21); variant translocations are very rare. Here, we describe an unusual case of double-hit pancreatic B-LBL with a variant translocation t(2;18)(p11;q21). Read More

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http://dx.doi.org/10.1007/s12185-019-02646-6DOI Listing
April 2019
1 Read

Acute appendicitis associated with the presence of schistosome eggs in a sailor: a case report.

Surg Case Rep 2019 Apr 8;5(1):55. Epub 2019 Apr 8.

Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki city, Nagasaki, 852-8501, Japan.

Background: Schistosomiasis is prevalent in tropical and subtropical areas and rarely reported in developed countries. Schistosomiasis often occurs as a chronic illness, which can cause liver and intestinal damage. Appendicitis is an unusual complication of schistosomiasis. Read More

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http://dx.doi.org/10.1186/s40792-019-0615-8DOI Listing
April 2019
1 Read

Safety Profile and Efficacy of Chemoembolization with Doxorubicin - Loaded Polyethylene Glycol Microspheres in Patients with Hepatocellular Carcinoma.

Open Access Maced J Med Sci 2019 Mar 11;7(5):742-746. Epub 2019 Mar 11.

Department for Gastroenterology and Hepatology, General City Hospital 8th September, Skopje, Republic of Macedonia.

Aim: This study was designed as a preliminary investigation of safety and efficacy of LifePearl, polyethylene glycol microspheres loaded with doxorubicin for treatment of locally untreatable (i.e., unresectable and not suitable for local thermal ablation) hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.3889/oamjms.2019.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447352PMC
March 2019
2 Reads

Is ramucirumab and paclitaxel therapy beneficial for second-line treatment of metastatic gastric or junctional adenocarcinoma for patients with ascites? Analysis of RAINBOW phase 3 trial data.

Cancer Manag Res 2019 20;11:2261-2267. Epub 2019 Mar 20.

Eli Lilly and Company, Taipei, Taiwan.

Purpose: Second-line treatment with ramucirumab-paclitaxel has demonstrated statistically significant and clinically meaningful survival outcomes compared to paclitaxel-alone in patients with advanced gastric cancer (HR=0.807, 95% CI 0.678-0. Read More

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http://dx.doi.org/10.2147/CMAR.S193739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433106PMC
March 2019
1 Read

Adoptive Transfer of NKG2D CAR mRNA-Engineered Natural Killer Cells in Colorectal Cancer Patients.

Mol Ther 2019 Mar 20. Epub 2019 Mar 20.

Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China. Electronic address:

By fusing the extracellular domain of the natural killer (NK) cell receptor NKG2D to DAP12, we constructed a chimeric antigen receptor (CAR) to improve NK cell tumor responses. An RNA electroporation approach that provides transient expression of the CAR was adopted as a risk mitigation strategy. Expression of the NKG2D RNA CAR significantly augmented the cytolytic activity of NK cells against several solid tumor cell lines in vitro and provided a clear therapeutic benefit to mice with established solid tumors. Read More

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http://dx.doi.org/10.1016/j.ymthe.2019.03.011DOI Listing
March 2019
1 Read

Evaluation of Antitumor Activity and Hepatoprotective Effect of Mitomycin C Solubilized in Chamomile Oil Nanoemulsion.

Anticancer Agents Med Chem 2019 Apr 8. Epub 2019 Apr 8.

Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah. Saudi Arabia.

Purpose: The present study aimed to investigate the antitumor activity and hepatoprotective effect of the MTC, when combined with CHAM oil nanoemulsion (NE), (CHAM-MTC) on the tumor growth.

Materials/methods: The in vitro study has assessed the antineoplastic effect of CHAM-MTC on the MCF-7 breast cancer cells while the in vivo therapeutic effectiveness and toxicities of CHAM-MTC were evaluated in Ehrlich ascites carcinoma (EAC) bearing mice. One hundred female Swiss albino mice, divided equally into non-EAC group (negative control), untreated EAC group (positive control) and three EAC groups received once intraperitoneal injection of 0. Read More

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http://dx.doi.org/10.2174/1871520619666190408114732DOI Listing
April 2019
2 Reads

Novel Thiazine Substituted 9-Anilinoacridines: Synthesis, Antitumour activity and Structure-Activity Relationships.

Anticancer Agents Med Chem 2019 Apr 8. Epub 2019 Apr 8.

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, ( Constituent college of JSS Academy of Higher Education & Research, Deemed University) Udhagamandalam - 643001 (Tamilnadu). India.

9-anilinoacridines are acting as DNA-intercalating agents which plays an important role as antitumor drugs, due to their anti-proliferative properties. Some anticancer agents contain 9-anilinoacridines such as amsacrine (m-AMSA), and nitracrine (Ledakrine) have been already developed. In this study, novel 9-anilinoacridines substituted with thiazines 4a-r were designed, synthesized, characterized by physical and spectral data and their cytotoxic activities against DLA cell lines were evaluated. Read More

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http://dx.doi.org/10.2174/1871520619666190408134224DOI Listing
April 2019
1 Read

Calcium Channel Blocker-Related Chylous Ascites: A Systematic Review and Meta-Analysis.

J Clin Med 2019 Apr 5;8(4). Epub 2019 Apr 5.

Department of Internal Medicine, Chung Shan Medical University Hospital and Chung Shan Medical University, Taichung 40201, Taiwan.

Background: Chylous ascites is an uncommon condition characterized by a white, milky-appearing peritoneal fluid, and is related to disruption of the lymphatic system from any cause. There have been very few previous reports of calcium channel blockers (CCBs) as potential causes of chylous ascites, and most of the patients were undergoing peritoneal dialysis.

Aims: To review the pathogenesis, clinical manifestations, laboratory examinations, treatment options, and prognosis of patients with CCB-related chylous ascites. Read More

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http://dx.doi.org/10.3390/jcm8040466DOI Listing
April 2019
1 Read

Rapid recurrence of primary gastric choriocarcinoma after complete resection.

Int J Surg Case Rep 2019 Mar 30;57:138-141. Epub 2019 Mar 30.

Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Introduction: Primary gastric choriocarcinoma (PGC) is a rare and rapidly invasive tumor. We report a case of PGC diagnosed by endoscopic biopsy and treated with gastrectomy and chemotherapy.

Presentation Of Case: A 78-year-old man was referred to our hospital because esophagogastroduodenoscopy showed a tumor at the fornix of the stomach. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.045DOI Listing
March 2019
1 Read

Clinical course and mortality by etiology of liver cirrhosis in Sweden: a population based, long-term follow-up study of 1317 patients.

Aliment Pharmacol Ther 2019 Apr 8. Epub 2019 Apr 8.

Department of Clinical Sciences, Lund University, Lund, Sweden.

Background: Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy.

Aim: We compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based cohort of patients with incident cirrhosis.

Material And Methods: We used population-based medical registries for a cohort study of patients with liver cirrhosis diagnosed January 2001 to December 2010, in the Scania region of Sweden. Read More

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http://doi.wiley.com/10.1111/apt.15255
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http://dx.doi.org/10.1111/apt.15255DOI Listing
April 2019
8 Reads

Recurrence of pseudomyxoma peritonei after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

BJS Open 2019 Apr 27;3(2):195-202. Epub 2018 Sep 27.

Department of Digestive Surgery, Centre Hospitalier Lyon Sud, Université Claude Bernard Lyon 1, Lyon, France.

Background: Pseudomyxoma peritonei (PMP) is a rare clinical condition characterized by mucinous ascites, typically related to appendiceal or ovarian tumours. Current standard treatment involves cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), but recurrences occur in 20-30 per cent of patients. The aim of this study was to define the timing and patterns of recurrence to provide a basis for modifying follow-up of these patients. Read More

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http://dx.doi.org/10.1002/bjs5.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433307PMC
April 2019
3 Reads

An Extremely Giant Ovarian Mucinous Cystadenoma.

Gulf J Oncolog 2019 Jan;1(29):83-86

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Ovarian mucinous cystadenomas are cystic neoplasms lined by mucin-producing epithelial cells. They are mostly benign (80%) and frequently asymptomatic at early stages. The average diameter of ovarian mucinous cystadenomas ranges from 15 to 30 cm. Read More

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January 2019
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Prediction of Discharge Destination Following Major Hepatectomy.

HPB (Oxford) 2019 Apr 4. Epub 2019 Apr 4.

Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Surgery, VA Boston Healthcare System, West Roxbury, MA, USA.

Background: Anatomic hepatectomies can be associated with complicated post-operative recoveries, often with discharge to post-acute care facilities. This study identifies preoperative and intraoperative factors associated with increased risk for non-home discharge destination after major hepatectomy.

Methods: Patients undergoing major hepatectomy were identified in the NSQIP Targeted Hepatectomy Dataset (2014-2016). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.354DOI Listing
April 2019
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Assessment of CD133-positive extracellular membrane vesicles in pancreatic cancer ascites and beyond.

Med Mol Morphol 2019 Apr 5. Epub 2019 Apr 5.

Tissue Engineering Laboratories, Biotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Tatzberg 47-49, 01307, Dresden, Germany.

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http://dx.doi.org/10.1007/s00795-019-00221-wDOI Listing
April 2019
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A Case of Spontaneous Intraperitoneal Rupture of an Acute Necrotic Fluid Collection Associated with Necrotizing Pancreatitis.

Am J Case Rep 2019 Apr 5;20:459-464. Epub 2019 Apr 5.

Department of Surgery, University of North Carolina Medical Center, Chapel Hill, NC, USA.

BACKGROUND An acute necrotic fluid collection is a rare condition that occurs within four weeks of the onset of necrotizing pancreatitis. This report is of a case of spontaneous intraperitoneal rupture of an acute necrotic fluid collection that required emergency laparotomy. CASE REPORT A 61-year-old man presented with worsening symptoms following hospital discharge for necrotizing pancreatitis. Read More

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http://dx.doi.org/10.12659/AJCR.914571DOI Listing
April 2019
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A woman, age 35, with new-onset ascites.

Cleve Clin J Med 2019 Apr;86(4):257-262

Assistant Professor of Medicine, Division of Hospital Medicine, University of Kentucky Medical Center, Lexington, KY, USA.

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http://dx.doi.org/10.3949/ccjm.86a.17082DOI Listing

Incidence and Risk Factors Associated With 30-Day Readmission for Alcoholic Hepatitis.

J Clin Gastroenterol 2019 Apr 3. Epub 2019 Apr 3.

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester.

Background: Alcohol abuse and liver disease are associated with high rates of 30-day hospital readmission, but factors linking alcoholic hepatitis (AH) to readmission are not well understood. We aimed to determine the incidence rate of 30-day readmission for patients with AH and to evaluate potential predictors of readmission.

Methods: We used the Nationwide Readmissions Database to determine the 30-day readmission rate for recurrent AH between 2010 and 2014 and examined trends in readmissions during the study period. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001202DOI Listing
April 2019
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Milking the System: Dietary Therapy of Post-nephrectomy Chylous Ascites.

Dig Dis Sci 2019 Apr 4. Epub 2019 Apr 4.

Division of Gastroenterology and Hepatology, University of New Mexico School of Medicine Medical Center, MSC 10-5550, 1, Albuquerque, NM, USA.

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http://dx.doi.org/10.1007/s10620-019-05611-9DOI Listing
April 2019
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Concomitant fungal peritonitis and high ascitic amylase as a rare manifestation of gastric perforation.

Oxf Med Case Reports 2019 Mar 29;2019(3):omz022. Epub 2019 Mar 29.

Department of Gastroenterology and Hepatology, Al-Mouasat University Hospital, 00963112133000, Damascus, Syria.

High ascitic amylase concentration has been reported to be a characteristic of pancreatic ascites. However, values greater than 2000 U/l can also be seen in intestinal perforation. Fungal peritonitis is a serious entity that could also be caused by hollow viscous perforation. Read More

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http://dx.doi.org/10.1093/omcr/omz022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440265PMC
March 2019
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Transudative chylothorax associated with alcoholic cirrhosis.

Oxf Med Case Reports 2019 Mar 29;2019(3):omz019. Epub 2019 Mar 29.

Department of Respiratory Medicine, Yokkaichi Municipal Hospital, Sibata2-2-37, Shibata, Yokkaichi-shi, Mie, Japan.

We present the case of a 53-year-old man with decompensated alcoholic cirrhosis who was referred for right pleural effusion. After investigation, the patient was ultimately diagnosed with cirrhotic chylothorax. Chylothorax is a rare manifestation of cirrhosis, which results from the trans-diaphragmatic passage of chylous ascites. Read More

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http://dx.doi.org/10.1093/omcr/omz019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440272PMC
March 2019
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The effect of nutritional education and continuous monitoring on clinical symptoms, knowledge, and quality of life in patients with cirrhosis.

Gastroenterol Hepatol Bed Bench 2019 ;12(1):17-24

Research Center for Infectious Diseases of Digestive System, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Aim: In this study, we aimed to evaluate the effectiveness of an educational intervention in patients with liver cirrhosis.

Background: Liver cirrhosis is end stage of liver diseases with many complications that affects quality of life and nutritional status in cirrhotic patients. Today, educational intervention and nutritional counseling is a key factor for preventing disease process and improving quality of life in patients with chronic diseases. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441481PMC
January 2019

Efficacy and safety of apixaban in a patient with systemic venous thromboembolism associated with hereditary antithrombin deficiency.

J Cardiol Cases 2019 Mar 20;19(3):106-109. Epub 2018 Dec 20.

Department of Cardiology, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.

A 40-year-old man with progressively worsening dyspnea was admitted to our hospital. On physical examination, pulse oximetry results demonstrated 80% oxygen saturation in room air. The lungs sounded clear, and both extremities appeared normal, without pitting edema. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429534PMC

Squamous Cell Carcinoma Larynx with Malignant Ascites: a Rare Entity.

Indian J Surg Oncol 2019 Mar 26;10(1):210-212. Epub 2018 Nov 26.

Department: Surgical Oncology and Pathology, Bhagwan Mahaveer Cancer Hospital and Research Center, JLN Road, Jaipur, Rajasthan 302017 India.

Usual sites of the spread of the squamous cell carcinoma (SCC) larynx is regional-cervical lymphadenopathy. The lung is the most frequent site of distant metastasis, accounting for 66% of distant metastasis. Other metastatic sites include bone (22%), liver (10%), skin, mediastinum, and bone marrow. Read More

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http://dx.doi.org/10.1007/s13193-018-0828-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414568PMC
March 2019
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