49,135 results match your criteria Ascites

Apigenin in Cancer Prevention and Therapy: A Systematic Review and Meta-Analysis of Animal Models.

Crit Rev Oncol Hematol 2022 Jun 22:103751. Epub 2022 Jun 22.

Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh-202002, India. Electronic address:

Background: Apigenin is being increasingly recognized as a cancer chemopreventive agent. We aimed to investigate the anticancer effects of Apigenin in in-vivo studies to know its present research status and how close or how far it is from the clinics.

Methods: Several electronic databases such as PubMed, Springer, Cochrane, and ctri. Read More

View Article and Full-Text PDF

Hepatic Hydrothorax: A Narrative Review.

Pulm Ther 2022 Jun 25. Epub 2022 Jun 25.

Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, North Shields, Northumbria Way, Northumberland, Cramlington, NE23 6NZ, UK.

Hepatic hydrothorax (HH) represents a distinct clinical entity within the broader classification of pleural effusion that is associated with significant morbidity and mortality. The median survival of patients with cirrhosis who develop HH is 8-12 months. The diagnosis is typically made in the context of advanced liver disease and ascites, in the absence of underlying cardio-pulmonary pathology. Read More

View Article and Full-Text PDF

Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer.

Br J Cancer 2022 Jun 24. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Stanford Women's Cancer Center, Stanford Cancer Institute, Stanford, CA, USA.

Background: Macrophages are an important component of the tumour immune microenvironment (TME) and can promote tumour growth and metastasis. Macrophage-secreted chemokine-ligand-23 (CCL23) induces ovarian cancer cell migration via chemokine-receptor 1 (CCR1). However, the effect of CCL23 on other immune cells in the TME is unknown. Read More

View Article and Full-Text PDF

Systemic injury caused by taurocholate-induced severe acute pancreatitis in rats.

Exp Ther Med 2022 Jul 26;24(1):468. Epub 2022 May 26.

Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.

Systemic injury plays a central role in severe acute pancreatitis (SAP). Retrograde biliopancreatic duct infusion of sodium taurocholate (NaT) is commonly used to establish SAP animal models. To better characterize the systemic injury in this model, SAP was induced in Sprague-Dawley rats by NaT administration (3. Read More

View Article and Full-Text PDF

A Metabolomic Analysis of Cirrhotic Ascites.

Molecules 2022 Jun 20;27(12). Epub 2022 Jun 20.

Arthur G. Zupko Institute for Systems Pharmacology and Pharmacogenomics, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York, NY 11201, USA.

Ascites is a common complication of decompensated liver cirrhosis, and yet relatively little is known about its biochemical composition. We conducted two metabolomic investigations, comparing the profile of ascites from 33 cirrhotic patients and postoperative peritoneal drainage fluid from 33 surgical patients (Experiment 1). The profile of paired ascites and plasma was also compared in 17 cirrhotic patients (Experiment 2). Read More

View Article and Full-Text PDF

Spontaneous Bacterial Peritonitis: The Incremental Value of a Fast and Direct Bacterial Identification from Ascitic Fluids Inoculated in Blood Culture Bottles by MALDI-TOF MS for a Better Management of Patients.

Microorganisms 2022 Jun 9;10(6). Epub 2022 Jun 9.

Laboratory of Bacteriology, Centre Hospitalier Universitaire de Nice, 06200 Nice, France.

Spontaneous bacterial peritonitis (SBP) is a severe infection that requires fast and accurate antibiotic therapy to improve the patient outcome. Direct bacterial identification using MALDI-TOF mass spectrometry from ascitic fluid inoculated in blood culture bottles (BCBs) could therefore improve patients' management. We evaluated the impact of the implementation of this method for the treatment of patients. Read More

View Article and Full-Text PDF

Real-World Data on Ramucirumab Therapy including Patients Who Experienced Two or More Systemic Treatments: A Multicenter Study.

Cancers (Basel) 2022 Jun 16;14(12). Epub 2022 Jun 16.

Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo 180-8610, Japan.

Background: The present study aimed to clarify the efficacy and safety of ramucirumab in a real-world setting, including patients who experienced two or more systemic treatments or whose hepatic reserve was deteriorated.

Methods: In total, 79 patients with hepatocellular carcinoma (HCC) from 14 institutes throughout Japan were retrospectively analyzed. The response was evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) version 1. Read More

View Article and Full-Text PDF

Effect of L. on the Efficacy and Toxicity of Doxorubicin in Mice Bearing Ehrlich Ascites Carcinoma.

Antioxidants (Basel) 2022 May 31;11(6). Epub 2022 May 31.

Indian Council of Medical Research, National Institute of Traditional Medicine, Belagavi 590010, Karnataka, India.

Background And Objective: Doxorubicin is a widely used chemotherapeutic agent that causes oxidative stress leading to cardiotoxicity, hepatotoxicity, and nephrotoxicity. In contrast, L. has been recorded as an anticancer agent and found to be protective against multiple chemical-induced organ injuries, including heart, liver, and kidney injuries. Read More

View Article and Full-Text PDF

Chronic Enteropathy in Dogs-Epidemiologic Aspects and Clinical Characteristics of Dogs Presenting at Two Swedish Animal Hospitals.

Animals (Basel) 2022 Jun 9;12(12). Epub 2022 Jun 9.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Almas allé 8, 750 07 Uppsala, Sweden.

Information about prevalence and breed predisposition of canine chronic enteropathy (CE) is limited. The aim of this retrospective study was to investigate period prevalence, breed disposition, clinical features, diagnostic results, and treatment response of CE in dogs presenting at two Swedish animal hospitals during 2013-2018. A medical record search was performed to identify CE dogs including those with ≥3 visits because of gastrointestinal disease and/or that had undergone gastroduodenoscopy/colonoscopy during 2013-2018. Read More

View Article and Full-Text PDF

Hepatic encephalopathy.

Nat Rev Dis Primers 2022 Jun 23;8(1):43. Epub 2022 Jun 23.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that occurs in the course of acute or chronic liver disease. Besides ascites and variceal bleeding, it is the most serious complication of decompensated liver cirrhosis. Ammonia and inflammation are major triggers for the appearance of HE, which in patients with liver cirrhosis involves pathophysiologically low-grade cerebral oedema with oxidative/nitrosative stress, inflammation and disturbances of oscillatory networks in the brain. Read More

View Article and Full-Text PDF

Resolution of chylopericardium after balloon dilatation of tricuspid valve stenosis in a Labrador Retriever.

J Vet Cardiol 2022 May 18;42:47-51. Epub 2022 May 18.

AniCura Specialistisch Verwijscentrum Haaglanden, Frijdastraat 20a, Rijswijk, 2288 EZ, the Netherlands; Veterinaire Specialisten Vught, Reutsedijk 8a, Vught, 5264 PC, the Netherlands.

A 2-year-old 33 kg female castrated Labrador Retriever was referred for exercise intolerance, hyporexia, and abdominal distention. Point-of-care ultrasound revealed ascites, hepatic congestion, severe pericardial effusion, and cardiac tamponade. Pericardiocentesis was performed, and the chylous nature of the fluid was confirmed by cytology, triglyceride, and cholesterol measurements. Read More

View Article and Full-Text PDF

[Pseudohyperkalemia: clinical chemistry for the clinician].

Ned Tijdschr Geneeskd 2022 Jun 20;166. Epub 2022 Jun 20.

LUMC, afd. Interne Geneeskunde, Leiden.

Background: Hyperkalemia is an electrolyte disorder requiring medical attention because it can cause cardiac arrhythmias. Pseudohyperkalemia is the phenomenon of an elevated potassium concentration that is present in the blood sample but not in the patient. Pseudohyperkalemia can be caused by hemolysis, leukocytosis, thrombocytosis, seasonal pseudohyperkalemia, potassium release from muscle cells due to fist clenching during venipuncture, and contamination due to blood withdrawal from an intravenous line over which potassium was administered. Read More

View Article and Full-Text PDF

A huge preperitoneal collection following acute necrotizing pancreatitis: A case report and the management approach.

Ann Med Surg (Lond) 2022 Jun 23;78:103843. Epub 2022 May 23.

Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction And Importance: Fluid collection is a critical complication of acute necrotizing pancreatitis. It is usually formed near the pancreas, but unusual collection sites have also been reported. Anterior extraperitoneal or preperitoneal collections following acute pancreatitis are rare and must be differentiated from pancreatic ascites, which is a collection of fluid in peritoneal cavity. Read More

View Article and Full-Text PDF

Prognostic factors for patients with mass-forming intrahepatic cholangiocarcinoma: A case series of 68 patients.

World J Gastrointest Surg 2022 May;14(5):442-451

Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China.

Background: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer in humans after hepatocellular carcinoma and a rare epithelial malignancy that results in a poor prognosis. According to the Liver Cancer Study Group of Japan classification, ICC can be divided into three types: Mass-forming (MF) type, periductal-infiltrating (PI) type, and intraductal-growth type. The MF type is the most common, accounting for 57. Read More

View Article and Full-Text PDF

Meconium Peritonitis Presenting with Nonimmune Hydrops and Mirror Syndrome.

J Indian Assoc Pediatr Surg 2022 May-Jun;27(3):362-364. Epub 2022 May 12.

Department of Obstetrics and Gynaecology, AIIMS, Bhubaneswar, Odisha, India.

Meconium peritonitis (MP) presenting as hydrops is a rare entity. A 34-week hydropic infant was born to mother diagnosed with a case of nonimmune hydrops. Postnatally, the neonate was diagnosed as a case of MP based on clinical examination and investigations. Read More

View Article and Full-Text PDF

The Usual Presentation of an Unusual Case: Spontaneous Primary Splenic Cyst Rupture.

Cureus 2022 May 18;14(5):e25097. Epub 2022 May 18.

Internal Medicine, Saint Mary's Hospital, Waterbury, USA.

Acute abdominal pain is one of the most common reasons for emergency admissions. Even though initial differentials are wide, a physician is able to narrow them down with detailed history, careful physical examination, and appropriate laboratory tests along with imaging studies. Unfortunately, some of the cases do not have an established diagnosis despite multiple blood work and imaging studies in the emergency department. Read More

View Article and Full-Text PDF

Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves.

BMC Complement Med Ther 2022 Jun 22;22(1):169. Epub 2022 Jun 22.

Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, 6205, Bangladesh.

Background: Pithecellobium dulce (Roxb.), an evergreen medium-sized, spiny tree which have vast nutritional values and widely used in ayurvedic medicines and home remedies. The plant has also been a rich source of biologically active compounds. Read More

View Article and Full-Text PDF

A Case of Hepatocellular Carcinoma Pseudoprogression Involving the Main Portal Vein, Right Ventricular Invasion, and Exacerbation of Lung Metastases in a Patient on Atezolizumab Plus Bevacizumab.

Intern Med 2022 Jun 21. Epub 2022 Jun 21.

Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Japan.

A 70-year-old man was diagnosed with hepatocellular carcinoma (HCC) with portal vein invasion and lung metastases, for which atezolizumab plus bevacizumab (ATZ/BEV) was initiated. After two months, computed tomography revealed tumor growth accompanied by ascites, right ventricular invasion, exacerbation of the lung metastases, and main portal vein invasion. However, continuation of ATZ/BEV caused remarkable size reductions in all lesions, finally resulting in the disappearance of the vascular invasion and lung metastases after nine cycles of treatment. Read More

View Article and Full-Text PDF

Emergency open drainage of massive hemoperitoneum and early stage left hepatectomy for abdominal compartment syndrome due to hepatocellular carcinoma rupture: a case report.

Surg Case Rep 2022 Jun 22;8(1):122. Epub 2022 Jun 22.

Department of Surgery, Hyogo Prefectural Amagasaki General Medical Center, 2-17-77, Higashinaniwa, Amagasaki, Hyogo, Japan.

Background: Spontaneous rupture is one of the most life-threatening complications of hepatocellular carcinoma (HCC). Transcatheter arterial embolization (TAE) effectively achieves hemostasis in patients with hemodynamic instability. However, there have been no reports of abdominal compartment syndrome (ACS) caused by massive intra-abdominal hematoma after TAE. Read More

View Article and Full-Text PDF

Diagnosis of non-alcoholic fatty liver disease and its active screening in risk groups.

Cas Lek Cesk 2022 ;161(2):72-76

Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in developed countries, where it affects up to a quarter of the population. The groups at most risk are diabetics, obese and patients with dyslipidemia, i. e. Read More

View Article and Full-Text PDF

Resistance to systemic immune checkpoint inhibition in the peritoneal niche.

J Immunother Cancer 2022 Jun;10(6)

Department of Haematology-Oncology, National University Cancer Institute, Singapore

Immune checkpoint inhibition (ICI) is an established therapeutic option for patients with deficient mismatch repair or high levels of microsatellite instability tumors. Yet, response to ICI among this group is varied, with nearly one-third of patients exhibiting primary resistance. Initial efforts in studying mechanisms of resistance to ICI have focused on intrinsic tumor factors. Read More

View Article and Full-Text PDF

Treatment of severe fetal Ebstein's anomaly with prenatal non-steroidal anti-inflammatory therapy.

Fetal Diagn Ther 2022 Jun 21. Epub 2022 Jun 21.

Introduction: Prenatally diagnosed Ebstein's anomaly with tricuspid valve dysplasia (EA/TVD) is a rare and high-risk congenital heart malformation with limited effective treatments. We report a case of severe fetal EA with hydrops treated with modest doses of non-steroidal anti-inflammatory drug (NSAID) therapy, resulting in reversal of hydrops and a favorable fetal outcome.

Case Presentation: Fetal heart defects included an inferiorly displaced tricuspid valve, severe tricuspid regurgitation, significantly dilated right atrium, and hypoplastic pulmonary valve with moderate regurgitation resulting in a circular shunt across the ductus arteriosus. Read More

View Article and Full-Text PDF

New phthalimide-based derivatives as EGFR-TK inhibitors: Synthesis, biological evaluation, and molecular modeling study.

Bioorg Chem 2022 Jun 14;127:105966. Epub 2022 Jun 14.

Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address:

A novel series of phthalimide derivatives was synthesized and evaluated for in vitro antitumor activity against six human cancer cell lines; HepG-2, HCT-116, MCF-7, Hep2, PC3 and Hela.The obtained results revealed that compound 32 was the most potent antitumor, while compounds 33, 22 and 24 showed strong activity against all tested cell lines. Further biological evaluation of the most active compounds was done and their in vitro EGFR-TK inhibition was tested, and the results came in accordance with the results of antitumor testing, where 32 displayed promising inhibitory activity (IC = 0. Read More

View Article and Full-Text PDF

MR elastography outperforms shear wave elastography for the diagnosis of clinically significant portal hypertension.

Eur Radiol 2022 Jun 21. Epub 2022 Jun 21.

BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Objectives: Portal hypertension (PH) is associated with complications such as ascites and esophageal varices and is typically diagnosed through invasive hepatic venous pressure gradient (HVPG) measurement, which is not widely available. In this study, we aim to assess the diagnostic performance of 2D/3D MR elastography (MRE) and shear wave elastography (SWE) measures of liver and spleen stiffness (LS and SS) and spleen volume, to noninvasively diagnose clinically significant portal hypertension (CSPH) using HVPG measurement as the reference.

Methods: In this prospective study, patients with liver disease underwent 2D/3D MRE and SWE of the liver and spleen, as well as HVPG measurement. Read More

View Article and Full-Text PDF

Post-PRRT scans: which scans to make and what to look for.

Cancer Imaging 2022 Jun 17;22(1):29. Epub 2022 Jun 17.

Department of Nuclear Medicine, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands.

Aim: The aim of this study was to evaluate the clinical utility of SPECT/CT (imaging of uptake in tumor lesions and additional findings) and the additional value of planar imaging in order to simplify clinical imaging protocols and decrease patients burden.

Materials And Methods: One hundred consecutive patients with metastatic neuroendocrine tumor (NET) treated with PRRT were included. Post-therapy imaging was performed 24 h after each PRRT cycle by both whole-body planar imaging and abdominal- and thoracic SPECT/CT. Read More

View Article and Full-Text PDF

Revealing the human mucinome.

Nat Commun 2022 Jun 20;13(1):3542. Epub 2022 Jun 20.

Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, 94305, CA, USA.

Mucin domains are densely O-glycosylated modular protein domains found in various extracellular and transmembrane proteins. Mucin-domain glycoproteins play important roles in many human diseases, such as cancer and cystic fibrosis, but the scope of the mucinome remains poorly defined. Recently, we characterized a bacterial O-glycoprotease, StcE, and demonstrated that an inactive point mutant retains binding selectivity for mucin-domain glycoproteins. Read More

View Article and Full-Text PDF

Ruptured granulosa cell tumor of the ovary presenting with catastrophic intra-abdominal hemorrhage: A case report.

Int J Surg Case Rep 2022 Jun 15;96:107317. Epub 2022 Jun 15.

Niagara Falls Memorial Medical Center, Niagara Falls, NY, United States of America.

Introduction And Importance: Adult granulosa cell tumor (GCT) is a rare stromal cell neoplasm that most often arises from the ovary. Presenting symptoms are related to external compression of adjacent structures (mass effect) or secretion of hormones such as estrogen. Patients most commonly present with irregular menstruation, postmenopausal bleeding, and abdominal pain. Read More

View Article and Full-Text PDF

Deep learning for emergency ascites diagnosis using ultrasonography images.

J Appl Clin Med Phys 2022 Jun 20:e13695. Epub 2022 Jun 20.

Department of Ultrasound, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Purpose: The detection of abdominal free fluid or hemoperitoneum can provide critical information for clinical diagnosis and treatment, particularly in emergencies. This study investigates the use of deep learning (DL) for identifying peritoneal free fluid in ultrasonography (US) images of the abdominal cavity, which can help inexperienced physicians or non-professional people in diagnosis. It focuses specifically on first-response scenarios involving focused assessment with sonography for trauma (FAST) technique. Read More

View Article and Full-Text PDF

Persistent Eosinophilia and Fever in Pancreatitis: A Clinical Conundrum.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221104465

Medical College of Georgia, Augusta, USA.

A healthy 11-year-old girl presents with epigastric abdominal pain, fever, weight loss, and decreased appetite for 1 month. On physical examination, she appears ill, dehydrated, and cachectic. Her abdominal examination is significant for large ascites with a fluid wave and is nontender to palpation. Read More

View Article and Full-Text PDF