43,865 results match your criteria Ascites


Modified FOLFOX6 as a first-line treatment for patients with advanced gastric cancer with massive ascites or inadequate oral intake.

Onco Targets Ther 2018 23;11:8301-8307. Epub 2018 Nov 23.

Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,

Background: Oral fluoropyrimidine plus platinum is a standard first-line treatment for advanced gastric cancer (AGC). However, this treatment is problematic for AGC patients with massive ascites or inadequate oral intake. This study aimed at evaluating the efficacy and safety of modified oxaliplatin (L-OHP) with l-leucovorin (l-LV) and bolus/continuous infusion of 5-fluorouracil (5-FU) (mFOLFOX6) regimen for patients with massive ascites or inadequate oral intake. Read More

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November 2018

Clinical Utility of Staging Laparoscopy for Advanced Obstructing Rectal Adenocarcinoma: Emerging Tool.

Indian J Surg Oncol 2018 Dec 2;9(4):488-494. Epub 2018 Aug 2.

1Department of Gastrointestinal Surgery and Colorectal Surgical Oncology, Tata Memorial Hospital, Dr Ernest Borges Marg, Parel, Mumbai, Maharashtra 400012 India.

The multimodal treatment for advanced rectal adenocarcinoma mandates accurate preoperative staging with contrast-enhanced computed tomography (CECT) of the thorax, abdomen, and pelvis, and magnetic resonance imaging (MRI) of the pelvis. Unlike gastric cancer, the role of staging laparoscopy (SL) in advanced colorectal cancer has not been evaluated. This study aims to evaluate the clinical value of SL in treatment decision-making for advanced rectal cancer (RC) with near or complete obstructing tumors. Read More

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December 2018

Validation of the albumin-indocyanine green evaluation model in patients with resected hepatocellular carcinoma and comparison with the albumin-bilirubin score.

J Hepatobiliary Pancreat Sci 2018 Dec 8. Epub 2018 Dec 8.

Department of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy.

Background: The albumin-indocyanine green evaluation (ALICE) model based on serum albumin and indocyanine retention rate, has been shown to be an effective method for predicting postoperative outcomes in hepatocellular carcinoma patients. Aim of the study was to validate the ALICE model in a large Western cohort of patients by comparing the Albumin-Bilirubin (ALBI) score and Child-Turcotte-Pugh (CTP) score.

Methods: A total of 400 patients who underwent hepatic resection from 01/2005 to 06/2016 at 3 centers were enrolled. Read More

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December 2018

[Thrombotic microangiopathy developing subsequent to tocilizumab therapy in a patient with TAFRO syndrome].

Rinsho Ketsueki 2018 ;59(11):2432-2437

Department of Pathology, Hakodate Municipal Hospital.

We report a case of a 60-year-old male who presented with fever and anasarca as well as hepatosplenomegaly, general lymphadenopathy, and disseminated intravascular coagulation (DIC), and was, therefore, admitted to our hospital. In addition, the patient suffered from respiratory failure and renal dysfunction and had pleural effusion and ascites. The pathological diagnosis from lymph node biopsy suggested multicentric Castleman's disease of the plasma cell type; however, the presence of high IL-6 levels, myelofibrosis, thrombocytopenia, anasarca, renal dysfunction, and hepatosplenomegaly led to a definitive diagnosis of TAFRO syndrome. Read More

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January 2018

[Ruptured ascending colonic varices in a patient with alcoholic liver cirrhosis treated using topical skin adhesive:a case study].

Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1087-1093

Third Department of Internal Medicine, Nara Medical University.

A 59-year-old man had been admitted to our hospital because of general malaise and abdominal fullness caused by massive ascites. He was diagnosed with alcoholic liver cirrhosis. Following the removal of ascites, he was referred to our department because of hematochezia. Read More

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January 2018

Sorafenib with or without concurrent transarterial chemoembolization in patients with advanced hepatocellular carcinoma: a phase III STAH trial.

J Hepatol 2018 Dec 5. Epub 2018 Dec 5.

Keimyung University Dongsan Medical Center, South Korea.

Background/aims: To compare clinical outcomes of sorafenib combined with concurrent conventional transarterial chemoembolization (cTACE) (SOR+T) with those of sorafenib alone in patients with advanced hepatocellular carcinoma (HCC) in an investigator-initiated, multicenter, randomized, phase III trial.

Methods: After randomization, all eligible patients received sorafenib with (Arm C, n=170) or without (Arm S, n=169) cTACE within 3 days and cTACE within 7-21 days, with repeated cTACE on demand (Arm C). The primary endpoint was overall survival (OS). Read More

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December 2018

The contribution and perspectives of proteomics to uncover ovarian cancer tumor markers.

Transl Res 2018 Nov 20. Epub 2018 Nov 20.

Department of Biochemistry and Immunology, FMRP, University of São Paulo, Ribeirão Preto, SP, Brazil; Center for Cell Based Therapy, Hemotherapy Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil. Electronic address:

Despite all the advances in understanding the mechanisms involved in ovarian cancer (OC) development, many aspects still need to be unraveled and understood. Tumor markers (TMs) are of special interest in this disease. Some aspects of clinical management of OC might be improved by the use of validated TMs, such as differentiating subtypes, defining the most appropriate treatment, monitoring the course of the disease, or predicting clinical outcome. Read More

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November 2018

The serum-ascites vitamin D gradient (SADG): A novel index in spontaneous bacterial peritonitis.

Clin Res Hepatol Gastroenterol 2018 Oct 24. Epub 2018 Oct 24.

Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples "Federico II", Naples, Italy. Electronic address:

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October 2018

Abdominal ascites in children as the presentation of eosinophilic gastroenteritis: A surgeon's perspective.

Clin Res Hepatol Gastroenterol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pediatric Surgery, Shengjing Hospital of China Medical University, 36, Sanhao Street, Heping district, Shenyang 110004, PR China. Electronic address:

Background: Abdominal ascites is a common problem in general surgery. The causes include parasitic diseases, tuberculosis, malignancies, hypoalbuminemia, abdominal inflammatory diseases, and peritonitis. Eosinophilic gastroenteritis (EG) has also been reported to be an infrequent cause. Read More

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December 2018

Lymphatic interventions for isolated, iatrogenic chylous ascites: A multi-institution experience.

Eur J Radiol 2018 Dec 25;109:41-47. Epub 2018 Oct 25.

Department of Radiology, Division of Vascular and Interventional Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, United states.

Objectives: Lymphangiography and thoracic duct embolization are established treatments for post-surgical chylothorax. There is only limited experience in their application to treat post-surgical chylous ascites. A multi-center analysis of the technical and clinical success of lymphangiography and lymphatic interventions in the treatment of isolated, iatrogenic chylous ascites is reported. Read More

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December 2018
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Preoperative discrimination of tumour stage in clear cell carcinoma of the ovary using computed tomography and magnetic resonance imaging.

Eur J Radiol 2018 Dec 22;109:19-26. Epub 2018 Oct 22.

Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: Clear cell carcinoma (CCC) of the ovary shows distinct clinical characteristics depending on the stage. We aimed to investigate the imaging predictability for tumour stage in CCC.

Patients And Methods: Fifty-six tumours in 48 patients with pathologically proven CCC were enrolled. Read More

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December 2018

An Unusual Case of Cardiac Tamponade Secondary to an Elevated Right Hemidiaphragm.

Can J Cardiol 2018 Dec 19;34(12):1688.e21-1688.e23. Epub 2018 Oct 19.

Northern Ontario School of Medicine, Health Sciences North, Sudbury, Ontario, Canada. Electronic address:

Diaphragmatic eventration in old age is a rare phenomenon. Typically, it is thought to originate as a result of failure of development of the muscles of the diaphragm. Less commonly, it can occur secondary to acquired conditions resulting from spinal cord or phrenic nerve injury and is only detected incidentally when the patient presents with dyspnea, chest infection, or cardiac compression symptoms. Read More

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December 2018

Activation of LXRɑ/β by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer.

BMC Cancer 2018 Dec 10;18(1):1232. Epub 2018 Dec 10.

Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

Background: The purpose of this study was to investigate the role of malignant ascites tumor microenvironment in ovarian cancer progression and chemoresistance.

Methods: A total of 45 patients with ovarian cancer and three benign ascites were collected at the time of clinical intervention. Ascites cholesterol levels were quantitated using cholesterol quantitation kit and recurrence free survival (RFS) of ovarian cancer patients were collected. Read More

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December 2018

Chylous ascites and podocytopathy as the presentation of childhood lupus-an unusual occurrence.

Lupus 2018 Dec 8:961203318817831. Epub 2018 Dec 8.

1 Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect virtually any organ. Chylous ascites as a presenting manifestation of SLE has been described in a handful of cases in adults. However, to the best of our knowledge this presentation has never been reported in the pediatric age group. Read More

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December 2018

Geodorum densiflorum rhizome lectin inhibits Ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of BAX, p53 and NF-κB genes expression.

Int J Biol Macromol 2018 Dec 4. Epub 2018 Dec 4.

Department of Biochemistry and Molecular Biology, Faculty of Science, University of Rajshahi, Rajshahi 6205, Bangladesh. Electronic address:

A lectin with a molecular mass of 12 ± 1 kDa was isolated for the first time from Geodorum densiflorum (Lam.) rhizome (GDL). The lectin exhibited hemagglutination activity both in mice and human erythrocytes which was inhibited by 4-nitrophenyl-β-D-glucopyranoside among the tested 26 sugars. Read More

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December 2018
3 Reads
2.858 Impact Factor

The comparative analysis of phenotypic and whole transcriptome gene expression data of ascites susceptible versus ascites resistant chickens.

Mol Biol Rep 2018 Dec 5. Epub 2018 Dec 5.

Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.

Ascites syndrome (AS) is a metabolic disorder that mainly occurs at later ages of meat-type chickens. Despite many research, there is no consensus about the origin of this syndrome. Our main purpose were to investigate the syndrome using both phenotypic and RNA-Seq data to elucidate the most causative factors predisposing the birds to AS. Read More

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December 2018

Life threatening polyserositis post oesophagectomy.

Respir Med Case Rep 2019 15;26:42-44. Epub 2018 Nov 15.

Great Western Hospital, Swindon, Marlborough Road, SN3 6BB, UK.

A 46 year old lady presented three weeks after an oesophagectomy for oesophageal carcinoma with increasing breathlessness and a large left-sided pleural effusion. Computed tomography (CT) scan of her thorax, abdomen and pelvis revealed a large left-sided and small right-sided pleural effusions, a pericardial effusion, ascites and intra-abdominal lymphadenopathy. The patient underwent both pericardial and pleural fluid drainage, however, unfortunately, deteriorated despite these interventions with increasing oxygen requirements requiring nasal high flow oxygen on the Intensive Care Unit. Read More

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November 2018

Porous diaphragm syndrome with recurrent thymoma.

Respirol Case Rep 2019 Feb 28;7(2):e00391. Epub 2018 Nov 28.

Department of Medical Oncology Izumi City General Hospital Izumi Japan.

Porous diaphragm syndrome describes a defect in the diaphragm in which substances pass from the peritoneal cavity to the pleural space. Defects may be congenital or acquired. Acquired defects are caused by the thinning and eventual splitting of collagen fibres in the tendinous part of the diaphragm. Read More

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February 2019

ABO Blood Type Has No Impact on Survival in Patients with Epithelial Ovarian Cancer.

J Cancer 2018 21;9(23):4334-4340. Epub 2018 Oct 21.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Evidence for an association between ABO blood type and epithelial ovarian cancer (EOC) survival has so far been limited and conflictive. This study applied a retrospective cohort and included 627 EOC patients diagnosed at Shengjing Hospital of China Medical University between 2011 and 2015. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) between the ABO blood type and progression-free survival (PFS) and overall survival (OS) of EOC patients were assessed using multivariable Cox proportional regression models. Read More

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October 2018
3 Reads

Prognostic Influence of the Time Interval between Surgery and Chemotherapy in Epithelial Ovarian Cancer.

J Cancer 2018 18;9(22):4172-4178. Epub 2018 Oct 18.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

The influence of time to chemotherapy (TTC) on recurrence and survival among epithelial ovarian cancer (EOC) patients still remains unknown. This single center retrospective cohort study was conducted on 489 EOC patients who underwent surgery followed by taxane- plus platinum-based chemotherapy in the Shengjing Hospital of China Medical University between 2011 and 2015. The Multivariate cox proportional regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for progression-free survival (PFS) and overall survival (OS) after adjustment for potential confounders. Read More

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October 2018

Emergence of tigecycline resistance in co-producing MCR-1 and NDM-5 during tigecycline salvage treatment.

Infect Drug Resist 2018 13;11:2241-2248. Epub 2018 Nov 13.

Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China,

Objective: Here, we report a case of severe infection caused by that harbored , , and acquired resistance to tigecycline during tigecycline salvage therapy.

Methods: Antimicrobial susceptibility testing, Southern blot hybridization, and complete genome sequence of the strains were carried out. The genetic characteristics of the and plasmids were analyzed. Read More

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November 2018

Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer.

Br J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Background: Advanced cancer causes necrosis and releases damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs activate neutrophils, including generation of neutrophil extracellular traps (NETs), which are injurious, thrombogenic, and implicated in metastasis. We hypothesised that extracellular mitochondrial DNA (mtDNA) in ascites from patients with epithelial ovarian cancer (EOC) would correlate with worse outcomes. Read More

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December 2018

The Benefits of Neuromuscular Electrical Stimulation in the Muscular and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a Randomized Clinical Trial.

Clin Med Insights Gastroenterol 2018 26;11:1179552218811834. Epub 2018 Nov 26.

Universidade do Estado de Santa Catarina (UDESC), Florianópolis, Brazil.

Cirrhosis causes systemic and metabolic changes that culminate in various complications, such as compromised pulmonary function, ascites, hepatic encephalopathy, weight loss, and muscle weakness with significant physical function limitations. Our aim is to evaluate the effects of training with neuromuscular electrical stimulation (NMES) on the muscular and functional capacity of patients with cirrhosis classified as Child-Pugh B and C. A total of 72 patients diagnosed with cirrhosis will be recruited and randomized to perform an NMES protocol for 50 minutes, 3 times a week, for 4 weeks. Read More

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November 2018
1 Read

Outcomes of Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Severe Cirrhosis and Ineligibility for Transplant.

Anticancer Res 2018 Dec;38(12):6815-6820

Allegheny Health Network, Division of Radiation Oncology, Pittsburgh, PA, U.S.A.

Background/aim: Our study reviewed the results of patients with hepatocellular carcinoma and Child-Pugh score 8-11 cirrhosis treated with stereotactic body radiotherapy when liver transplant was not an option.

Patients And Methods: A retrospective review was performed on 15 patients with Child-Pugh class B and C cirrhosis treated with stereotactic body radiotherapy. The median total dose was 35 Gy in 4-5 fractions. Read More

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December 2018

Portal hypertension: The desperate search for the placenta.

Curr Res Transl Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery. School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.

We propose that the circulatory impairments produced, in both portal hypertension and liver cirrhosis, to a certain degree resemble those characterizing prenatal life in the fetus. In fact, the left-right circulatory syndrome is common in cirrhotic patients and in the fetus. Thus, in patients with portal hypertension and chronic liver failure, the re-expression of a blood circulation comparable to fetal circulation is associated with the development of similar amniotic functions, i. Read More

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November 2018

WITHDRAWN: Purification and characterizations of a new mannose specific lectin from Bangladeshi cultivated sword bean with antiproliferative activities against Ehrlich ascites carcinoma cells in vivo in mice.

Int J Biol Macromol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacy, Faculty of Biomedical Sciences, Khwaja Yunus Ali University, Sirajgonj, Bangladesh.

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www. Read More

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November 2018

Permanent peritoneal ports for the management of recurrent malignant ascites: a retrospective review of safety and efficacy.

Intern Med J 2018 Dec;48(12):1524-1528

Palliative Care Services, Counties Manukau District Health Board, Middlemore Hospital, Auckland, New Zealand.

Large volume paracentesis is effective in relieving the symptoms of malignant ascites, but frequent procedures are often required. Permanent peritoneal ports are an alternative to repeated procedures. We describe our experience with the use of peritoneal ports in patients at Middlemore Hospital (Auckland, New Zealand) who had a port inserted for the drainage of malignant ascites. Read More

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December 2018
4 Reads

Distribution of platinum between nuclear and cytosolic fractions - Can subcellular fractionation be performed quantitatively?

J Pharm Biomed Anal 2018 Nov 20;165:82-89. Epub 2018 Nov 20.

University of Copenhagen, Department of Pharmacy, Universitetsparken 2, 2100 Copenhagen Ø, Denmark. Electronic address:

The feasibility of quantitatively tracking platinum, derived from platinum-based compounds, during subcellular fractionation was studied. Cisplatin-exposed murine Ehrlich Lettré Ascites cells were fractionated into cytosolic and crude nuclear fractions. The latter was subsequently purified. Read More

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November 2018

Prenatal sonographic diagnosis of isolated fetal ascites in cri-du-chat (5p-) syndrome: A case report.

J Clin Ultrasound 2018 Dec 4. Epub 2018 Dec 4.

Molecular Genetics and Pathology Unit, Hospital of Divino Espirito Santo of Ponta Delgada, EPER, São Miguel Island, Azores, Portugal.

Isolated fetal ascites and cri-du-chat syndrome (CdCS; OMIM #123450) are two very rare conditions that, to our best knowledge, have never been reported together. Here, we describe a case of isolated fetal ascites detected in the first trimester ultrasound, with no other remarkable signs. After an extensive work-up (fetal ultrasound, serologies, Coombs test, and NIPT), an amniocentesis was performed and revealed an abnormal karyotype of 46,XX,del (p15. Read More

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December 2018
0.801 Impact Factor

Usefulness of bioelectrical impedance analysis for monitoring patients with refractory ascites.

Rev Esp Enferm Dig 2018 Dec 4;111. Epub 2018 Dec 4.

UCG Digestive Diseases and CIBEREHD, Hospital Universitario de Valme Spain , Spain.

Background: bioelectrical impedance analysis is a technique for the determination of the hydropic component. The hydropic component, determined by blood volume, could be a reflection of the hemodynamic situation. This study aimed to evaluate the usefulness of peripheral bioelectrical impedance analysis (BIA) for the prediction of hemodynamic changes in large-volume paracentesis and prognosis. Read More

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December 2018
1 Read

Effective Targeting of TAG72 Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells.

Front Immunol 2018 19;9:2268. Epub 2018 Nov 19.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, United States.

Impressive clinical efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy for hematological malignancies have prompted significant efforts in achieving similar responses in solid tumors. The lack of truly restricted and uniform expression of tumor-associated antigens, as well as limited T cell persistence and/or tumor trafficking pose major challenges for successful translation of CAR T cell therapy in solid tumors. Recent studies have demonstrated that aberrantly glycosylated cell surface proteins on tumor cells are amenable CAR targets. Read More

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November 2018

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment.

Redox Biol 2018 Nov 17. Epub 2018 Nov 17.

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA, USA. Electronic address:

Ovarian cancer remains the most lethal gynecologic malignancy, and is primarily diagnosed at late stage when considerable metastasis has occurred in the peritoneal cavity. At late stage abdominal cavity ascites accumulation provides a tumor-supporting medium in which cancer cells gain access to growth factors and cytokines that promote survival and metastasis. However, little is known about the redox status of ascites, or whether antioxidant enzymes are required to support ovarian cancer survival during transcoelomic metastasis in this medium. Read More

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November 2018
3 Reads

Peritoneal fluid stimulates neoplastic transformation of normal HEK 293 cells by high expression of pluripotent genes.

Pol J Pathol 2018 ;69(3):399-310

Gynecological cancers constitute a serious problem in the world. Their advanced stages are often characterized by the accumulation of ascites, which leads to spreading of cancer cells outside their primary focus. Despite progress in the treatment, prognoses are still not satisfactory. Read More

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January 2018

Serum sodium as a risk factor for hepatic encephalopathy in patients with cirrhosis and ascites.

J Gastroenterol Hepatol 2018 Nov 30. Epub 2018 Nov 30.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Background: Hyponatremia is associated with development of hepatic encephalopathy (HE), but the nature of the relationship between serum sodium and HE incidence is unknown. We examined the association between serum sodium, changes in serum sodium, and HE incidence using data from three randomised trials of satavaptan in cirrhosis patients with ascites.

Methods: During follow-up, patients were examined for HE, and serum sodium was measured regularly. Read More

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November 2018
1 Read

Anti-phospholipid Antibody Syndrome Presenting as Huge Ascites: A Case Report.

Mymensingh Med J 2018 Oct;27(4):883-887

Dr Abed Hussain Khan, Assistant Professor, Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Antiphospholipid Syndrome (APS) is characterized by arterial, venous or small vessel thromboses and/or pregnancy morbidity in the presence of persistently elevated titers of antiphospholipid antibodies. Since virtually any organ can be involved, the clinical presentation of APS is very varied. Abdominal manifestations are rare but may be life-threatening, and include Budd-Chiari Syndrome. Read More

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October 2018
2 Reads

Clinical Outcome and Predictive Factors of Variceal Bleeding in Patients with Hepatocellular Carcinoma in Thailand

Asian Pac J Cancer Prev 2018 Nov 29;19(11):3301-3305. Epub 2018 Nov 29.

Gastroenterology Unit, Department of Medicine, Faculty of Medicine, Thammasat University Hospital, Pathumthani, Thailand. Email:

Objective: Hepatocellular carcinoma (HCC) is common cancer in ASEAN. Variceal bleeding (VB) is considered to be fatal complication of cirrhosis with HCC. However, limited studies were reported in ASEAN. Read More

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November 2018

[The clinical characteristics and risk factors for acute kidney injury in patients with cirrhosis].

Zhonghua Nei Ke Za Zhi 2018 Dec;57(12):912-916

Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.

To investigate the clinical features and risk factors for acute kidney injury (AKI) in patients with cirrhosis. A total of 1 165 hospitalized patients with chronic liver diseases were enrolled. Among them, 94 patients had chronic hepatitis, while 1 071 patients were diagnosed as cirrhosis. Read More

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December 2018

Critical Care Management of Gastrointestinal Bleeding and Ascites in Liver Failure.

Semin Respir Crit Care Med 2018 Oct 28;39(5):566-577. Epub 2018 Nov 28.

Division of Gastroenterology and Hepatology, Center for Liver Diseases and Transplantation, Weill Cornell Medical College, New York, New York.

Gastrointestinal (GI) bleeding and ascites are two significant clinical events that frequently present in critically ill patients with chronic liver failure or decompensated cirrhosis. GI bleeding in patients with cirrhosis, particularly portal hypertensive-associated bleeding, carries a high short-term mortality (15-25%) and requires early initiation of a vasoactive agent and antibiotics as well as timely endoscopic management. Conservative transfusion strategies and adequate airway protection are also imperative to assist in bleeding control. Read More

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October 2018
2 Reads

Kidney Injury and Electrolyte Abnormalities in Liver Failure.

Semin Respir Crit Care Med 2018 Oct 28;39(5):556-565. Epub 2018 Nov 28.

Department of Critical Care Medicine, Mayo Clinic, Phoenix, Arizona.

The liver and kidney are key organs of metabolic homeostasis in the body and display complex interactions. Liver diseases often have direct and immediate effects on renal physiology and function. Conversely, acute kidney injury (AKI) is a common problem in patients with both acute and chronic liver diseases. Read More

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October 2018
3 Reads

Applicability of tumor spheroids for in vitro chemosensitivity assays.

Expert Opin Drug Metab Toxicol 2018 Nov 28. Epub 2018 Nov 28.

a Department of Surgery , Medical University of Vienna , Vienna , Austria.

Introduction: Drug screening assays employing 2D-cultures of cancer cells have been largely replaced by 3D multicellular tumor spheroid (MCTS) models which more closely represent patient's tumors. The predictive power of the different MCTSs depends on source of the cells, techniques of preparation and characteristics of the aggregates. Areas covered: The preparation of MCTSs and a comparison of the spheroids assembled from permanent cancer and patient-derived cell lines in respect to the correlation of their chemosensitivity to clinical responses are discussed. Read More

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November 2018

Mesenchymal stem cell therapy for advanced liver cirrhosis: A case report.

JGH Open 2017 Dec 7;1(4):153-155. Epub 2017 Dec 7.

Division of Gastroenterology, Department of Medicine, Faculty of Medicine University of Malaya Medical Centre Kuala Lumpur Malaysia.

Mesenchymal stem cell (MSC) transplant may offer an alternative to liver transplantation in patients with end-stage liver disease. However, its efficacy remains uncertain. MSC was performed on a 50-year-old male with decompensated (Child-Turcotte-Pugh grade C) alcoholic liver cirrhosis due to an absence of donors for adult-deceased and living-related liver transplantation. Read More

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December 2017

Aggressive nutrition intervention reduces ascites and frequency of paracentesis in malnourished patients with cirrhosis and ascites.

JGH Open 2017 Nov 31;1(3):92-97. Epub 2017 Oct 31.

Liver Injury and Cancer Centenary Research Institute Sydney New South Wales Australia.

Background And Aim: Alterations in nutrient metabolism, nutritional requirements, and reduced dietary intakes are common in chronic liver disease (CLD). These result in malnutrition, sarcopenia, and exacerbate progression to decompensation and ascites. We aimed to investigate the effects of continuous tube feeding (TF) on nutritional status and levels of ascites in malnourished individuals with decompensated cirrhosis. Read More

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November 2017
1 Read

Bacteriological profile of intra-abdominal infections in a tertiary care hospital.

Iran J Microbiol 2018 Aug;10(4):208-214

Nizam's Institute of Medical Sciences Panjagutta, Hyderabad, Telangana, India.

Background And Objectives: Intra-abdominal infections (IAIs) include a wide spectrum of pathological conditions, ranging from uncomplicated appendicitis to fecal peritonitis .The resulting infections should be diagnosed early and treated based on the organism isolated and its susceptibility. In this study the bacteriological profile and antimicrobial resistance pattern of intra-abdominal infections was analyzed. Read More

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August 2018
4 Reads

Management of malignancy-associated bowel obstruction by cervical esophagostomy and total parenteral nutrition, case series of 2 patients.

Int J Surg Case Rep 2018 Nov 16;53:390-393. Epub 2018 Nov 16.

Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA.

Background: Patients with gastrointestinal or gynecologic malignancy may show disease progression within the abdomen and pelvis causing bowel obstruction in the absence of clinical evidence of disease outside of the peritoneal space. Bowel obstruction eventually results and has a profound effect on quality of life eventually leading to the demise of these patients.

Methods: In order to improve the quality of life and combat the requirement for a nasogastric tube, a combination of total parenteral nutrition (TPN) to allow adequate caloric intake plus cervical esophagostomy to drain intestinal secretions was utilized as a palliative treatment long-term for patients with malignancy-associated bowel obstruction. Read More

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November 2018
4 Reads

Role of Ultrasound-Guided Fine-Needle Aspiration Cytology of Omentum in Diagnosis of Abdominal Tuberculosis.

Surg Infect (Larchmt) 2018 Nov 27. Epub 2018 Nov 27.

2 Department of Gastroenterology, Postgraduate Institute of Medical Education and Research , Chandigarh, India .

Aim: To evaluate the efficacy of ultrasound-guided (USG) fine-needle aspiration cytology examination (FNAC) of the omentum in the diagnosis of abdominal tuberculosis (TB).

Methods: Retrospective review was conducted of data from patients who presented with clinically suspected peritoneal TB between June 2016 and April 2018. We included patients in whom imaging showed omental thickening with or without ascites. Read More

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November 2018
1 Read

A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion.

Cell Death Discov 2018 21;4:108. Epub 2018 Nov 21.

1Department of Pathology, Wake Forest University Health Sciences, Winston-Salem, 27157 NC USA.

Prior studies suggest a possibility that the anticancer property of garlic is more effective only when exposed directly to cancer cells than absorbed first by the normal epithelial cells of the gastrointestinal tract wall. We tested this possibility in two mouse models of highly aggressive malignancies that cannot yet be cured by conventional therapies: sarcoma 180- and EL4-induced lethal ascites. Daily oral gavages of raw garlic extract (RGE; equivalent to 100 mg wet weight) for 21 days failed to offer any meaningful effect in the mice with malignancies. Read More

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November 2018

Loss of TXNIP enhances peritoneal metastasis and can be abrogated by dual TORC1/2 inhibition.

Oncotarget 2018 Nov 2;9(86):35676-35686. Epub 2018 Nov 2.

Department of Biomedical Informatics, Division of Bioinformatics, The Ohio State University, Columbus, OH 43210, USA.

Peritoneal metastasis (PM) is a debilitating consequence of multiple cancers. As cancer cells lose tonic signaling related to attachment dependence, critical morphologic shifts result in alteration of the transcriptome. Identifying key genes associated with this transformation may lead to targeted therapies for this devastating complication. Read More

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November 2018
4 Reads

Meconium pseudocyst presenting as massive ascites in a new-born.

Radiol Case Rep 2019 Feb 16;14(2):235-237. Epub 2018 Nov 16.

Neonatal Intensive Care Unit, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, United Kingdom.

Meconium pseudocyst (MPC) is a rare but well-known surgical condition due to prenatal bowel perforation. A case of MPC secondary to prenatal bowel perforation is presented. Massive ascites requiring peritoneal drainage and disappearance of prenatal intraperitoneal calcifications have not been previously reported in MPC. Read More

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February 2019
1 Read

Giant Splenic Aneurysm with Arteriovenous (A-V) Shunt, Portal Hypertension, and Ascites.

Am J Case Rep 2018 Nov 27;19:1410-1415. Epub 2018 Nov 27.

Vascular Surgery Clinic, AHEPA University General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

BACKGROUND Splenic aneurysms are rare, asymptomatic, and usually derive from previous surgical interventions. Endovascular repair is the best option, but when A-V shunt is present, open repair might be more suitable. CASE REPORT A 43-year-old man presented to the Internal Medicine Department of AHEPA University Hospital with symptoms of fever and ascites. Read More

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November 2018
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Transjugular intrahepatic portosystemic shunt as a bridge to liver transplant: Current state and future directions.

Transplant Rev (Orlando) 2018 Oct 31. Epub 2018 Oct 31.

Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States; Division of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States; Yale Cancer Center, Yale School of Medicine, New Haven, CT, United States. Electronic address:

Liver transplantation is one of the mainstays of treatment for liver failure due to severe chronic liver disease. Bridging therapies, such as placement of a transjugular intrahepatic portosystemic shunt (TIPS), are frequently employed to control complications of portal hypertension such as ascites, hydrothorax, and variceal bleeding, and thereby reduce morbidity in patients awaiting transplant. There is no significant difference seen in either graft survival or patient survival between those receiving TIPS pre-transplant and those who do not, although those receiving TIPS placement on average have a longer waiting time on the transplant waitlist. Read More

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October 2018
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