4,914 results match your criteria Asbestosis


Outcomes after Lung Transplantation for Patients with Occupational Lung Diseases.

Clin Transplant 2018 Dec 2:e13460. Epub 2018 Dec 2.

Division of Lung Failure and Lung Transplantation, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

Occupational lung diseases (OLD) including silicosis, asbestosis, and pneumoconiosis progress to end stage lung disease requiring lung transplantation (LT). Prognosis and treatment of OLDs are poorly understood and a paucity of data exists regarding LT outcomes. Additionally, transplant operative complexity for patients with OLD is high. Read More

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December 2018
4 Reads

Asbestos-Related Diseases in Turkey: Not Only Caused by Naturally Occurring Fibers, but Also by Industrial Exposures.

Am J Respir Crit Care Med 2018 Nov 29. Epub 2018 Nov 29.

Bezmialem Vakif Universitesi Tip Fakultesi, 221266, Chest Diseases, Istanbul, Turkey.

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November 2018
1 Read
12.996 Impact Factor

Transbronchial lung cryobiopsy: a novel confirmatory tool to diagnose asbestos-related pulmonary fibrosis.

Respirol Case Rep 2019 Jan 9;7(1):e00380. Epub 2018 Nov 9.

Department of Respiratory and Sleep Medicine Liverpool Hospital Sydney, New South Wales Australia.

Asbestosis is diagnosed with a combination of historical, clinical and radiological findings in the absence of another cause. Histology is required when uncertainty exists, with lung biopsy via VATs being gold standard. Transbronchial cryobiopsy is becoming increasingly popular for diagnosing interstitial lung disease and may provide sufficient lung sample to demonstrate asbestosis. Read More

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January 2019
2 Reads

Spatial analysis of asbestos exposure and occupational health care in Poland during the period 2004-2013.

Geospat Health 2018 11 9;13(2). Epub 2018 Nov 9.

Department of Geoinformatics, Cartography and Remote Sensing, Faculty of Geography and Regional Studies, University of Warsaw, Warsaw.

Asbestos is carcinogenic to humans and exposure to this substance can cause a wide range of diseases. In Poland 1997, a statutory ban was introduced on the production, use and marketing of products containing asbestos. The National Programme for Asbestos Abatement for 2009-2032 includes scheduled activities considering asbestos exposure assessment and health protection. Read More

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November 2018
4 Reads

Breath analysis as a diagnostic and screening tool for malignant pleural mesothelioma: a systematic review.

Transl Lung Cancer Res 2018 Oct;7(5):520-536

Laboratory of Experimental Medicine and Paediatrics, Antwerp University, Wilrijk, Belgium.

Malignant pleural mesothelioma (MPM) is a tumour related to a historical exposure to asbestos fibres. Currently, the definite diagnosis is made only by the histological examination of a biopsy obtained through an invasive thoracoscopy. However, diagnosis is made too late for curative treatment because of non-specific symptoms mainly appearing at advanced stage disease. Read More

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October 2018
5 Reads

[The German Mesothelioma Register : Current pathological diagnostics and services].

Pathologe 2018 Nov 16. Epub 2018 Nov 16.

Georgius Agricola Stiftung Ruhr, Deutsches Mesotheliomregister, Institut für Pathologie, Ruhr-Universität Bochum, Bürkle-de-la-Camp Platz 1, 44789, Bochum, Deutschland.

Background: In Germany, asbestos-related diseases (asbestosis, lung cancer, mesothelioma) are recognised and compensated occupational diseases. The histologic diagnosis of mesothelioma is sometimes a challenge; additional immunohistochemical and molecular methods are needed. With lung dust analysis, the current asbestos fibre burden of the lung is measured (biomonitoring). Read More

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November 2018
7 Reads

Shorter telomere length and DNA hypermethylation in peripheral blood cells of coal workers.

Mutat Res 2018 Dec 28;836(Pt B):36-41. Epub 2018 Mar 28.

Laboratory of Genetic Toxicology, Postgraduate Program in Molecular and Cell Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil. Electronic address:

Coal is a mixture of several chemicals, mainly inorganic elements and polycyclic aromatic hydrocarbons, many of which have mutagenic and carcinogenic effects. Pneumoconiosis, fibrosis, asbestosis, silicosis, emphysema, loss of lung function and cancer are some examples of coal-related disorders. The aim of this study was to analyze coal miners with respect to telomere length (TL) and percentage (%) of global DNA methylation. Read More

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December 2018
5 Reads

Monsanto, PCBs, and the creation of a "world-wide ecological problem".

J Public Health Policy 2018 Nov;39(4):463-540

Mailman School of Public Health, Center for the History & Ethics of Public Health, Columbia University, 722 West 168th Street Room 935, New York, NY, 10032, USA.

For the past three decades, we have written on the history of occupational and environmental health, authoring books and articles on lead poisoning, silicosis, asbestosis, and angiosarcoma of the liver, among other diseases. One book, Deceit and Denial, focused specifically on the chemical and lead industries. Because of the rarity of historians who study this history, we have been asked to testify on behalf of workers who allege harm from these industrial materials and by state, county, and local governments who seek redress for environmental damages and funds to prevent future harm to children. Read More

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November 2018
7 Reads

Asbestos Trust Transparency.

Authors:
Mark A Behrens

Fordham Law Rev 2018 Oct;87(1):107-24

Shook, Hardy & Bacon L.L.P., Washington, DC.

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October 2018
1 Read

Occupational Burden of Asbestos-Related Diseases in Korea, 1998-2013: Asbestosis, Mesothelioma, Lung Cancer, Laryngeal Cancer, and Ovarian Cancer.

J Korean Med Sci 2018 Aug 19;33(35):e226. Epub 2018 Jul 19.

Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Background: Asbestos exposure causes asbestos-related diseases (ARDs) including asbestosis, malignant mesothelioma, lung cancer, laryngeal cancer, and ovarian cancer. Although Korea used substantial amounts of asbestos in the past, no study has focused on its occupational burden of disease (OBD). Therefore, this study aimed to determine the OBDs of ARDs in Korea. Read More

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August 2018
6 Reads

Measuring EMPs in the lung what can be measured in the lung: Asbestiform minerals and cleavage fragments.

Authors:
Victor L Roggli

Toxicol Appl Pharmacol 2018 Jun 27. Epub 2018 Jun 27.

Department of Pathology, Duke University Medical Center, M255 Davison Bldg. Durham, NC 27710, United States. Electronic address:

Asbestos mineral fibers have been associated with the development of a variety of diseases in humans and experimental animals, including asbestosis, lung cancer, and mesothelioma. Asbestos includes several mineral types divided into two mineral groups, serpentine and amphibole forms. Chrysotile is the serpentine mineral classified as asbestos, whereas the amphiboles include amosite, crocidolite, tremolite, actinolite and anthophyllite. Read More

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June 2018
2 Reads

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis.

Environ Int 2018 Oct 27;119:174-185. Epub 2018 Jun 27.

Radboud Institute for Health Sciences, Radboudumc, Nijmegen, the Netherlands. Electronic address:

Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years attributable to pneumoconiosis from occupational exposure to dusts and/or fibres, to inform the development of the WHO/ILO joint methodology.

Objectives: We aim to systematically review studies on occupational exposure to dusts and/or fibres (Systematic Review 1) and systematically review and meta-analyse estimates of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis (Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework. Read More

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October 2018
12 Reads

[Asbestosis and pleural plaques].

Ugeskr Laeger 2018 Jun;180(25)

Asbestos was used in numerous products until its total ban in Denmark in 1988. The prevalence of asbestosis and pleural plaques does not yet appear to be falling. Unfortunately the statistics are unreliable due to errors in the Danish translation of the ICD-10 codes of the disease. Read More

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June 2018
3 Reads

[Work-up of asbestosis and estimation of asbestos exposure in an occupational context].

Ugeskr Laeger 2018 May;180(22)

Asbestosis is interstitial lung fibrosis due to inhalation of asbestos fibres. Up to the ban of import in 1986, 0.7 mil tons had been used in Denmark. Read More

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May 2018
5 Reads

[Health impact of asbestos fibres naturally occurring in Mount Pollino area (Basilicata Region, Southern Italy)].

Epidemiol Prev 2018 Mar-Apr;42(2):142-150

Dipartimento ambiente e salute, Istituto superiore di sanità, Roma.

Objectives: to estimate the health impact of asbestos fibres naturally occurring in Mount Pollino area (Basilicata Region, Southern Italy).

Design: geographic mortality, hospitalization, and incidence study. Setting and participant s: population resident in 12 Municipalities of Mount Pollino area with naturally occurring asbestos fibres. Read More

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May 2018
3 Reads

Global Asbestos Disaster.

Int J Environ Res Public Health 2018 05 16;15(5). Epub 2018 May 16.

WSH Institute, MOMSC, Singapore, ICOH c/o INAIL, Monteporzio Catone, 00078 Rome, Italy.

: Asbestos has been used for thousands of years but only at a large industrial scale for about 100⁻150 years. The first identified disease was asbestosis, a type of incurable pneumoconiosis caused by asbestos dust and fibres. The latest estimate of global number of asbestosis deaths from the Global Burden of Disease estimate 2016 is 3495. Read More

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May 2018
3 Reads

Dosimetry of inhaled elongate mineral particles in the respiratory tract: The impact of shape factor.

Toxicol Appl Pharmacol 2018 May 5. Epub 2018 May 5.

U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.

Inhalation exposure to some types of fibers (e.g., asbestos) is well known to be associated with respiratory diseases and conditions such as pleural plaques, fibrosis, asbestosis, lung cancer, and mesothelioma. Read More

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May 2018
2 Reads

Review on the adverse health effects of asbestiform antigorite, a non-regulated asbestiform serpentine mineral.

Authors:
Xaver Baur

Am J Ind Med 2018 Jul 7;61(7):625-630. Epub 2018 May 7.

European Society for Environmental and Occupational Medicine, Berlin, Germany.

Background: Although antigorite is generally described as platy, its fibrous (asbestiform) variant is present widespread in serpentinite rocks. In addition to its primarily fibrous occurrence, asbestiform antigorite may also be formed from serpentinite with massive appearance during tunneling and mining. It is not of commercial interest, but exposure may occur in the certain environments. Read More

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July 2018
2 Reads

Evaluation of airborne asbestos exposure from routine handling of asbestos-containing wire gauze pads in the research laboratory.

Regul Toxicol Pharmacol 2018 Jul 30;96:135-141. Epub 2018 Apr 30.

Center for Environmental and Occupational Risk Analysis and Management, Department of Environmental and Occupational Health, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd., Tampa, FL, 33612, USA. Electronic address:

Three independently conducted asbestos exposure evaluations were conducted using wire gauze pads similar to standard practice in the laboratory setting. All testing occurred in a controlled atmosphere inside an enclosed chamber simulating a laboratory setting. Separate teams consisting of a laboratory technician, or technician and assistant simulated common tasks involving wire gauze pads, including heating and direct wire gauze manipulation. Read More

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July 2018
12 Reads

On the diagnosis of malignant pleural mesothelioma: A necropsy-based study of 171 cases (1997-2016).

Tumori 2018 Apr 1:300891618765538. Epub 2018 Apr 1.

4 Laboratory of Pathological Anatomy of Monfalcone, Italy.

Background: Malignant pleural mesothelioma (MPM) diagnosis is known to be difficult. We report on the diagnostic elements available in life in an MPM necropsy case series and describe the frequency of non-neoplastic asbestos-related diseases as biological exposure indices.

Methods: We reviewed pathologic and clinical records of an unselected series of autopsies (1977-2016) in patients with MPM employed in the Monfalcone shipyards or living with shipyard workers. Read More

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April 2018
21 Reads

Mortality in a cohort of asbestos-exposed workers undergoing health surveillance.

Med Lav 2018 02 6;109(2):83-86. Epub 2018 Feb 6.

Department of Medical Area (DAME), University of Udine, Udine, Italy.

Background: The coastal area of Friuli Venezia Giulia (FVG) region, north-eastern Italy, was characterized by work activities in which asbestos was used until the early 1990s, particularly in shipbuilding. A public health surveillance program (PHSP) for asbestos-exposed workers was established, although limited evidence exists about the efficacy of such programs in reducing disease occurrence and mortality.

Objectives: To compare mortality in a cohort of 2,488 men occupationally exposed to asbestos, enrolled in a PHSP in FVG between the early 1990s and 2008, with that of the general population of FVG and Italy. Read More

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February 2018
1 Read

[Diffuse Malignant Peritoneal Mesothelioma with Secondary Liver Invasion Diagnosed Using Laparoscopy - A Case Report].

Gan To Kagaku Ryoho 2018 Mar;45(3):449-453

Division of Surgery, Bellland General Hospital.

A 69-year-old man with right upper quadrant abdominal pain and fever was referred to our hospital. He had a history of asbestosis exposure. Computed tomography(CT)revealed a mass at the right subhepatic space, and an antibiotic was administered after a diagnosis of an abdominal abscess. Read More

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March 2018
22 Reads

Asbestosis is prevalent in a variety of construction industry trades.

NPJ Prim Care Respir Med 2018 Apr 3;28(1):11. Epub 2018 Apr 3.

Birmingham Regional NHS Occupational Lung Disease Service, Birmingham Chest Clinic, Birmingham, UK.

A diagnosis of asbestosis, which is a long-latency, fibrotic lung disease, has implications for the patient in terms of prognosis, treatment and compensation. Identifying and quantifying asbestos exposure is difficult without a detailed occupational history, and the threshold dose of asbestos required to cause asbestosis is not well understood. We reviewed all cases of asbestosis diagnosed between 2001 and 2016 at the Birmingham Regional NHS Occupational Lung Disease Service to determine the industries and occupations most frequently implicated in causation, in order to help clinicians identify where asbestosis might enter the differential diagnosis for a patient with chronic respiratory symptoms. Read More

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April 2018
2 Reads

Asbestos exposure biomarkers in the follow-up of asbestos-exposed workers.

Ind Health 2018 Jun 26;56(3):249-254. Epub 2018 Feb 26.

Department of Medical Biotechnology, University of Siena, Unit of Occupational Health Azienda Ospedaliera Universitaria Senese, Italy.

Health surveillance of asbestos exposed workers should be stratified according to the exposure level. Unfortunately there is a lack of information regarding asbestos exposure in many working places and markers of asbestos exposure are often needed. The aim of the study was to assess the reliability of different dose and effect biomarkers in the follow up of asbestos-exposed workers. Read More

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June 2018
7 Reads

Australia's Ongoing Legacy of Asbestos: Significant Challenges Remain Even after the Complete Banning of Asbestos Almost Fifteen Years Ago.

Int J Environ Res Public Health 2018 02 23;15(2). Epub 2018 Feb 23.

Asbestos Diseases Research Institute, P.O. Box 3628, Rhodes, NSW 2138, Australia.

The most effective way of reducing the global burden of asbestos-related diseases is through the implementation of asbestos bans and minimising occupational and non-occupational exposure to respirable asbestos fibres. Australia's asbestos consumption peaked in the 1970s with Australia widely thought to have had among the highest per-capita asbestos consumption level of any country. Australia's discontinuation of all forms of asbestos and asbestos-containing products and materials did not occur at a single point of time. Read More

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February 2018
23 Reads

Grade 4 asbestosis does not extend directly from the respiratory bronchiole to the peripheral lung.

Histopathology 2018 Jul 17;73(1):29-37. Epub 2018 Apr 17.

Division of Diagnostic Pathology, Saitama Prefectural Cardiovascular and Respiratory Centre, Saitama, Japan.

Aims: To confirm whether or not grade 4 asbestosis progresses from the respiratory bronchiole to the peripheral lung.

Methods And Results: We examined retrospectively the autopsy or lobectomy specimens from 31 cases (29 males; mean age 64 years) satisfying the pathological criteria of grade 4 asbestosis. Asbestos bodies (ABs) were quantified in samples of dissolved lung and in tissue preparations on glass slides. Read More

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July 2018
4 Reads

Asbestos-Related Disorders in Germany: Background, Politics, Incidence, Diagnostics and Compensation.

Authors:
Xaver Baur

Int J Environ Res Public Health 2018 01 16;15(1). Epub 2018 Jan 16.

European Society for Occupational and Environmental Medicine, EOM, Berlin, Germany.

There was some limited use of asbestos at end of the 19th century in industrialized countries including Germany, but its consumption dramatically increased after World War II. The increase in use and exposure was followed by the discovery of high numbers of asbestos-related diseases with a mean latency period of about 38 years in Germany. The strong socio-political pressure from the asbestos industry, its affiliated scientists and physicians has successfully hindered regulatory measures and an asbestos ban for many years; a restrictive stance that is still being unravelled in compensation litigation. Read More

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January 2018
3 Reads

Temporal Patterns of Exposure to Asbestos and Risk of Asbestosis: An Analysis of a Cohort of Asbestos Textile Workers.

J Occup Environ Med 2018 Jun;60(6):536-541

Department of Medical and Surgical Sciences (DIMEC), Bologna University, Bologna, Italy (Dr Farioli and Dr Violante); Department of Clinical Sciences and Community Health, Milan University, Milan, Italy (Dr La Vecchia and Mr Pelucchi); Department of Biomedical and Clinical Sciences, Milan University, Milan, Italy (Ms Negri); Department of Environmental Science, Safety, Territory, Food and Health, Messina University, Messina, Italy (Dr Spatari); Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York (Dr Boffetta); Department of Public Health Sciences and Pediatrics, Turin University, Turin, Italy (Dr Pira).

Objective: The aim of the study was to assess the risk of asbestosis death based on the temporal pattern of exposure to asbestos.

Methods: We followed up a cohort of asbestos textile workers, employed in 1946 to 1984, until November 2013. We measured the duration of the employment, the time since last employment (TSLE), the age, and the year of first employment. Read More

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June 2018
12 Reads

Biological responses to asbestos inhalation and pathogenesis of asbestos-related benign and malignant disease.

J Investig Med 2018 Apr 6;66(4):721-727. Epub 2018 Jan 6.

Internal Medicine - Division of Pulmonary and Critical Care Medicine, UC Davis Medical Center, Sacramento, California, USA.

Asbestos comprises a group of fibrous minerals that are naturally occurring in the environment. Because of its natural properties, asbestos gained popularity for commercial applications in the late 19th century and was used throughout the majority of the 20th century, with predominant use in the construction, automotive, and shipbuilding industries. Asbestos has been linked to a spectrum of pulmonary diseases, such as pleural fibrosis and plaques, asbestosis, benign asbestos pleural effusion, small cell lung carcinoma, non-small cell lung carcinoma, and malignant mesothelioma. Read More

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April 2018
12 Reads

Polyvinylidene Fluoride Alters Inflammatory Responses by Activation-induced Cell Death in Macrophages.

Immune Netw 2017 Dec 11;17(6):402-409. Epub 2017 Dec 11.

Department of Pharmacy, Korea University, Sejong 30019, Korea.

Carbon nanotubes (CNTs) are nanomaterials that have been employed in generating diverse materials. We previously reported that CNTs induce cell death in macrophages, possibly via asbestosis. Therefore, we generated CNT-attached polyvinylidene fluoride (PVDF), which is an established polymer in membrane technology, and then examined whether CNT-attached PVDF is immunologically safe for medical purposes compared to CNT alone. Read More

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December 2017
14 Reads

Chest physician-reported, work-related, long-latency respiratory disease in Great Britain.

Eur Respir J 2017 12 28;50(6). Epub 2017 Dec 28.

Centre for Occupational and Environmental Health, The University of Manchester, Manchester, UK.

Much of the current burden of long-latency respiratory disease (LLRD) in Great Britain is attributed to historical asbestos exposure. However, continuing exposure to other agents, notably silica, also contributes to disease burden. The aim of this study was to investigate the incidence of work-related LLRD reported by chest physicians in Great Britain, including variations by age, gender, occupation and suspected agent. Read More

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December 2017
7 Reads

Characterization of pulmonary responses in mice to asbestos/asbestiform fibers using gene expression profiles.

J Toxicol Environ Health A 2018 26;81(4):60-79. Epub 2017 Dec 26.

a Exposure Assessment Branch , NIOSH/CDC, Morgantown , WV , USA.

Humans exposed to asbestos and/or asbestiform fibers are at high risk of developing many lung diseases including asbestosis, lung cancer, and malignant mesothelioma. However, the disease-causing potential and specific metabolic mechanisms and pathways associated with various asbestos/asbestiform fiber exposures triggering different carcinogenic and non-carcinogenic outcomes are still largely unknown. The aim of this this study was to investigate gene expression profiles and inflammatory responses to different asbestos/asbestiform fibers at the acute/sub-acute phase that may be related to delayed pathological outcomes observed at later time points. Read More

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December 2017
13 Reads

High-resolution CT of the lungs: Indications and diagnosis.

Authors:
Helena Lauri

Duodecim 2017;133(6):549-56

High-resolution computed tomography (HRCT) is a method of examination which is more precise than chest 2-rat in the diagnosis and monitoring of diseases of the lung tissue and the airways. Modern CT equipment enables a volume HRCT scan covering the whole lung tissue. HRCT slices can also be constructed from contrast-enhanced CT scans of the chest of the whole body. Read More

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January 2018
4 Reads

Plasma Fibulin-3 as a Potential Biomarker for Patients with Asbestos-Related Diseases in the Han Population.

Dis Markers 2017 22;2017:1725354. Epub 2017 Oct 22.

Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.

Fibulin-3 has been reported as a potential biomarker for mesothelioma. However, little is known about the diagnostic efficacies of fibulin-3 for asbestos-related diseases (ARDs) in China. This study was to investigate the utility of fibulin-3 for asbestos exposure and ARDs. Read More

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July 2018
20 Reads

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction.

Nanotoxicology 2017 Nov - Dec;11(9-10):1211-1224. Epub 2017 Nov 25.

a IMT Mines Saint-Etienne , Centre CIS, INSERM, Université de Lyon, SainBioSE , Saint-Etienne , France.

Mineralogical analyses of clinical samples have been proved useful to identify causal relationship between exposure to airborne particles and pulmonary diseases. The most striking example is asbestosis where the assessment of asbestos bodies in patient lung samples has allowed defining values specific of pathologies. However, this type of analyses only considers the micro-sized fraction of the particles, neglecting the specific impact of nano-sized particles which have been otherwise shown to be reactive and able to induce biological effects. Read More

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April 2018
4 Reads

The Tale of Asbestos in Sweden 1972-1986-The Pathway to a Near-Total Ban.

Int J Environ Res Public Health 2017 11 22;14(11). Epub 2017 Nov 22.

Department of Medical Sciences-Occupational and Environmental Medicine, Uppsala University, 75185 Uppsala, Sweden.

This paper provides a narrative of the national intervention strategy in Sweden aimed to restrict the industrial use of asbestos. For many years, asbestos was imported for widespread industrial use, resulting in large amounts throughout Swedish society. In 1972, the whistle was blown in a Communist Party parliamentary motion describing asbestos as a health hazard and requesting action to prohibit its use. Read More

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November 2017
3 Reads

Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos.

Environ Health Prev Med 2017 Jun 9;22(1):53. Epub 2017 Jun 9.

Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.

The immunological effects of asbestos exposure on various lymphocytes such as the regulatory T cell (Treg), responder CD4+ T helper cell (Tresp), CD8+ cytotoxic T lymphocytes (CTL), and natural killer (NK) cells were investigated. Results show that asbestos exposure impairs antitumor immunity through enhancement of regulatory T cell function and volume, reduction of CXCR3 chemokine receptor in responder CD4+ T helper cells, and impairment of the killing activities of CD8+ cytotoxic T lymphocytes (CTL) and NK cells. These findings were used to explore biological markers associated with asbestos exposure and asbestos-induced cancers and suggested the usefulness of serum/plasma IL-10 and TGF-β, surface CXCR3 expression in Tresp, the secreting potential of IFN-γ in Tresp, intracellular perforin level in CTL, and surface expression NKp46 in NK cells. Read More

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June 2017
11 Reads

Usual interstitial pneumonia: typical, possible, and "inconsistent" patterns.

J Bras Pneumol 2017 Sep-Oct;43(5):393-398

. Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil.

Idiopathic pulmonary fibrosis is a severe and progressive chronic fibrosing interstitial lung disease, a definitive diagnosis being established by specific combinations of clinical, radiological, and pathological findings. According to current international guidelines, HRCT plays a key role in establishing a diagnosis of usual interstitial pneumonia (UIP). Current guidelines describe three UIP patterns based on HRCT findings: a typical UIP pattern; a pattern designated "possible UIP"; and a pattern designated "inconsistent with UIP", each pattern having important diagnostic implications. Read More

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January 2018
21 Reads

Serum concentrations of Krebs von den Lungen-6, surfactant protein D, and matrix metalloproteinase-2 as diagnostic biomarkers in patients with asbestosis and silicosis: a case-control study.

BMC Pulm Med 2017 Nov 17;17(1):144. Epub 2017 Nov 17.

Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chao-Yang District, Beijing, 100020, China.

Background: Asbestosis and silicosis are progressive pneumoconioses characterized by interstitial fibrosis following exposure to asbestos or silica dust. We evaluated the potential diagnostic biomarkers for these diseases.

Methods: The serum concentrations of Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and matrix metalloproteinase-2 (MMP-2), MMP-7, and MMP-9 were measured in 43 patients with asbestosis, 45 patients with silicosis, 40 dust-exposed workers (DEWs) without pneumoconiosis, and 45 healthy controls (HCs). Read More

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November 2017
9 Reads

Occupational lung diseases in Australia.

Med J Aust 2017 Nov;207(10):443-448

Monash University, Melbourne, VIC

Occupational exposures are an important determinant of respiratory health. International estimates note that about 15% of adult-onset asthma, 15% of chronic obstructive pulmonary disease and 10-30% of lung cancer may be attributable to hazardous occupational exposures. One-quarter of working asthmatics either have had their asthma caused by work or adversely affected by workplace conditions. Read More

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November 2017
8 Reads

Mesothelioma in Australia: a review.

Med J Aust 2017 Nov;207(10):449-452

Sir Charles Gairdner Hospital, Perth, WA.

The incidence of malignant mesothelioma in Australia is among the highest in the world as a result of widespread use of asbestos by industry and in construction throughout the 20th century. The risk of developing malignant mesothelioma after asbestos exposure is dose-related; a transient, low dose exposure confers a correspondingly very low risk of disease. Malignant mesothelioma is a heterogeneous disease, partly explaining the limited role of biomarkers in screening and diagnosis. Read More

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November 2017
6 Reads

Author reply: 'Response to: Pleural abnormalities in the Framingham Heart Study: prevalence and CT image features' by Araki .

Occup Environ Med 2018 01 9;75(1):77-78. Epub 2017 Nov 9.

Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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January 2018
12 Reads

Asbestos Exposures, Mesothelioma Incidence and Mortality, and Awareness by General Practitioners in the Molise Region, Central Italy.

J Occup Environ Med 2018 Feb;60(2):e90-e97

Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy (Drs Ripabelli, Tamburro, Ms Di Tella, Ms Sammarco); and Registri Tumori del Molise, Azienda Sanitaria Regionale del Molise (A.S.R.E.M.), Campobasso, Italy (Mr Carrozza).

Objective: The aim of this study was to evaluate environmental asbestos sources, mesothelioma incidence and mortality, and awareness on asbestos-related diseases (ARDs) by general practitioners (GPs) in Molise Region.

Methods: The contaminated sites in three towns were identified by census; mesothelioma incidence (2000 to 2012) and mortality (2003 to 2013) was achieved from local registries; GPs were interviewed on practiced population's exposures and ARDs diagnosis.

Results: About 54. Read More

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February 2018
4 Reads

Parenchymal asbestosis due to primary asbestos exposure among ship-breaking workers: report of the first cases from Bangladesh.

BMJ Case Rep 2017 Nov 3;2017. Epub 2017 Nov 3.

John Hopkins University-Projahnmo, Dhaka, Bangladesh.

We report for the first time asbestosis among ship-breaking workers of Sitakunda in Bangladesh who were exposed to asbestos during ship-based and beach-based operations for at least 10 years. Asbestosis was present among 35% of workers. Years of work (>20) and forced vital capacity (<80% of predicted) were significantly associated with the disease. Read More

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November 2017
4 Reads

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany.

Int J Occup Med Environ Health 2018 Jan 2;31(3):293-305. Epub 2017 Nov 2.

Ruhr University Bochum, Bochum, Germany (Institute for Pathology).

Objectives: This study has researched the significance of histologically raised findings and lung dust analyses in the context of claiming the recognition of and thus compensation for an asbestos-associated occupational disease.

Material And Methods: For this approach, all findings from the German Mesothelioma Register in 2015 that included lung dust analyses were evaluated and were compared with information on asbestos fiber exposure at work based on fiber years, and with the results of radiological findings.

Results: For 68 insured persons, recognition of an asbestos-induced lung disease according to Section 4104 of the German Ordinance on Occupational Diseases (Berufskrankheitenverordnung - BKV) could be recommended solely on the basis of the histological examinations of lung tissues and complementary lung dust analyses. Read More

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January 2018
12 Reads

Association between increased small airway obstruction and asbestos exposure in patients with asbestosis.

Clin Respir J 2018 Apr 23;12(4):1676-1684. Epub 2017 Nov 23.

Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Background: Asbestos exposure may cause asbestos-related lung diseases including asbestosis, pleural abnormalities and malignancies. The role of asbestos exposure in the development of small airway obstruction remains controversial. Anatomic and physiologic small airway abnormalities may develop as part of the pathophysiologic process of asbestosis. Read More

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April 2018
10 Reads

Differences between peritoneal and pleural mesothelioma in Lombardy, Italy.

Cancer Epidemiol 2017 12 23;51:68-73. Epub 2017 Oct 23.

Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.

Background: We examined characteristics of peritoneal (PEM) and pleural (PLM) mesothelioma in Lombardy, Italy.

Methods: From the Lombardy Mesothelioma Registry we selected PEM (N=300) and PLM (N=5011) cases diagnosed in 2000-2014. We investigated asbestos exposure and presence of asbestosis or pleural plaques. Read More

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December 2017
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Toward an Asbestos Ban in the United States.

Int J Environ Res Public Health 2017 10 26;14(11). Epub 2017 Oct 26.

Collegium Ramazzini, Castello di Bentivoglio via Saliceto, Bentivoglio, 340010 Bologna, Italy.

Many developed countries have banned the use of asbestos, but not the United States. There have, however, been multiple efforts in the US to establish strict exposure standards, to limit asbestos use, and to seek compensation through the courts for asbestos-injured workers' In consequence of these efforts, asbestos use has declined dramatically, despite the absence of a legally mandated ban. This manuscript presents a historical review of these efforts. Read More

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October 2017
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