682 results match your criteria Arzneimittelforschung-Drug Research[Journal]


Mussel-Inspired and Bioclickable Peptide Engineered Surface to Combat Thrombosis and Infection.

Research (Wash D C) 2022 14;2022:9780879. Epub 2022 Apr 14.

Affiliated Dongguan Hospital, Southern Medical University, Dongguan, Guangdong 523059, China.

Thrombosis and infections are the two major complications associated with extracorporeal circuits and indwelling medical devices, leading to significant mortality in clinic. To address this issue, here, we report a biomimetic surface engineering strategy by the integration of mussel-inspired adhesive peptide, with bio-orthogonal click chemistry, to tailor the surface functionalities of tubing and catheters. Inspired by mussel adhesive foot protein, a bioclickable peptide mimic (DOPA)-azide-based structure is designed and grafted on an aminated tubing robustly based on catechol-amine chemistry. Read More

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Direct Electron Transfer from Upconversion Graphene Quantum Dots to TiO Enabling Infrared Light-Driven Overall Water Splitting.

Research (Wash D C) 2022 13;2022:9781453. Epub 2022 Apr 13.

School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, China.

Utilization of infrared light in photocatalytic water splitting is highly important yet challenging given its large proportion in sunlight. Although upconversion material may photogenerate electrons with sufficient energy, the electron transfer between upconversion material and semiconductor is inefficient limiting overall photocatalytic performance. In this work, a TiO/graphene quantum dot (GQD) hybrid system has been designed with intimate interface, which enables highly efficient transfer of photogenerated electrons from GQDs to TiO. Read More

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Electrochemical Evaluation of Tumor Development via Cellular Interface Supported CRISPR/Cas Trans-Cleavage.

Research (Wash D C) 2022 6;2022:9826484. Epub 2022 Apr 6.

Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, China.

Evaluating tumor development is of great importance for clinic treatment and therapy. It has been known that the amounts of sialic acids on tumor cell membrane surface are closely associated with the degree of cancerization of the cell. So, in this work, cellular interface supported CRISPR/Cas trans-cleavage has been explored for electrochemical simultaneous detection of two types of sialic acids, i. Read More

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Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N-Methyladenosine-Modified Expression.

Research (Wash D C) 2022 7;2022:9825916. Epub 2022 Apr 7.

Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China.

Circular RNAs take crucial roles in several pathophysiological processes. The regulatory role and its underlying mechanisms of circ-ZNF609 in the heart remains largely unknown. Here, we report that circ-ZNF609 is upregulated during myocardial ischemia/reperfusion (I/R) remodeling. Read More

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-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis.

Research (Wash D C) 2022 4;2022:9839368. Epub 2022 Apr 4.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China.

The transport and metabolism of lipids in cerebrovascular endothelial cells (ECs) have been hypothesized to regulate blood-brain barrier (BBB) maturation and homeostasis. Long-chain polyunsaturated fatty acids (LCPUFAs) as the important lipids components of cell membranes are essential for the development and function of BBB, but the direct links of lipid metabolism and ECs barrier function remain to be established. Here, we comprehensively characterize the transcriptomic phenotype of developmental cerebrovascular ECs in single-cell resolution and firstly find that -2-enoyl-CoA reductase (Tecr), a very-long-chain fatty acid synthesis, is highly expressed during barriergenesis and decreased after BBB maturation. Read More

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Mechanically Reinforced Silkworm Silk Fiber by Hot Stretching.

Research (Wash D C) 2022 30;2022:9854063. Epub 2022 Mar 30.

Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.

Silkworm silk, which is obtained from domesticated (), can be produced in a large scale. However, the mechanical properties of silkworm silk are inferior to its counterpart, spider dragline silk. Therefore, researchers are continuously exploring approaches to reinforce silkworm silk. Read More

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Investigation of the Phase Transition at the Surface of Thermoelectric PbTe with van der Waals Control.

Research (Wash D C) 2022 26;2022:9762401. Epub 2022 Mar 26.

Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, China.

The structure of thermoelectric materials largely determines the thermoelectric characteristics. Hence, a better understanding of the details of the structural transformation process/conditions can open doors for new applications. In this study, the structural transformation of PbTe (a typical thermoelectric material) is studied at the atomic scale, and both nucleation and growth are analyzed. Read More

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Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System.

Research (Wash D C) 2022 23;2022:9834093. Epub 2022 Mar 23.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Photosynthetic biohybrid systems exhibit promising performance in biosynthesis; however, these systems can only produce a single metabolite and cannot further transform carbon sources into highly valuable chemical production. Herein, a photosynthetic biohybrid system integrating biological and chemical cascade synthesis was developed for solar-driven conversion of glucose to value-added chemicals. A new ternary cooperative biohybrid system, namely bacterial factory, was constructed by self-assembling of enzyme-modified light-harvesting donor-acceptor conjugated polymer nanoparticles (D-A CPNs) and genetically engineered (). Read More

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High-Throughput Calculation of Interlayer van der Waals Forces Validated with Experimental Measurements.

Research (Wash D C) 2022 22;2022:9765121. Epub 2022 Mar 22.

State Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials, Northwestern Polytechnical University, Xi'an 710072, China.

Interlayer van der Waals interactions play an important role in two-dimensional (2D) materials on various occasions. The interlayer binding force is often directly measured and is considered more closely related to the exfoliation condition. However, a binding force database from accurate theoretical calculations does not yet exist. Read More

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In Situ 3D Bioprinting Living Photosynthetic Scaffolds for Autotrophic Wound Healing.

Research (Wash D C) 2022 20;2022:9794745. Epub 2022 Mar 20.

Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.

Three-dimensional (3D) bioprinting has been extensively explored for tissue repair and regeneration, while the insufficient nutrient and oxygen availability in the printed constructs, as well as the lack of adaptive dimensions and shapes, compromises the overall therapeutic efficacy and limits their further application. Herein, inspired by the natural symbiotic relationship between salamanders and algae, we present novel living photosynthetic scaffolds by using an in situ microfluidic-assisted 3D bioprinting strategy for adapting irregular-shaped wounds and promoting their healing. As the oxygenic photosynthesis unicellular microalga () was incorporated during 3D printing, the generated scaffolds could produce sustainable oxygen under light illumination, which facilitated the cell proliferation, migration, and differentiation even in hypoxic conditions. Read More

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High-Throughput Computational Screening for Bipolar Magnetic Semiconductors.

Research (Wash D C) 2022 15;2022:9857631. Epub 2022 Mar 15.

Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemical Physics, and Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.

Searching ferromagnetic semiconductor materials with electrically controllable spin polarization is a long-term challenge for spintronics. Bipolar magnetic semiconductors (BMS), with valence and conduction band edges fully spin polarized in different spin directions, show great promise in this aspect because the carrier spin polarization direction can be easily tuned by voltage gate. Here, we propose a standard high-throughput computational screening scheme for searching BMS materials. Read More

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Shape Memory Epoxy Resin and Its Composites: From Materials to Applications.

Research (Wash D C) 2022 16;2022:9767830. Epub 2022 Mar 16.

Centre for Composite Materials and Structures, Harbin Institute of Technology (HIT), Harbin 150080, China.

Shape memory polymers (SMPs) have historically attracted attention for their unique stimulation-responsive and variable stiffness and have made notable progress in aerospace, civil industry, and other fields. In particular, epoxy resin (EP) has great potential due to its excellent mechanical properties, fatigue resistance, and radiation resistance. Herein, we focus on the molecular design and network construction of shape memory epoxy resins (SMEPs) to provide opportunities for performance and functional regulation. Read More

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Glymphatic System and Subsidiary Pathways Drive Nanoparticles Away from the Brain.

Research (Wash D C) 2022 15;2022:9847612. Epub 2022 Mar 15.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Although drug delivery systems (DDS) are efficient in brain delivery, they face failure in clinical settings due to their potential toxicity to the central nervous system. Little is known about where the DDS will go after brain delivery, and no specific elimination route that shares a passage with DDS has been verified. Hence, identifying harmless DDS for brain delivery and determining their fate there would strongly contribute to their clinical translation. Read More

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Ten-Hour Stable Noninvasive Brain-Computer Interface Realized by Semidry Hydrogel-Based Electrodes.

Research (Wash D C) 2022 10;2022:9830457. Epub 2022 Mar 10.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

Noninvasive brain-computer interface (BCI) has been extensively studied from many aspects in the past decade. In order to broaden the practical applications of BCI technique, it is essential to develop electrodes for electroencephalogram (EEG) collection with advanced characteristics such as high conductivity, long-term effectiveness, and biocompatibility. In this study, we developed a silver-nanowire/PVA hydrogel/melamine sponge (AgPHMS) semidry EEG electrode for long-lasting monitoring of EEG signal. Read More

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Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultraminimal-Invasive Biomarker Detection with Mechanical Robustness.

Research (Wash D C) 2022 7;2022:9869734. Epub 2022 Mar 7.

State Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.

Microneedle permits transdermal biosensing and drug delivery with minor pain. However, accurate microneedle transdermal positioning with minimal skin deformation remains a significant technical challenge due to inhomogeneous skin topology and discontinuous force applied to the microneedle. Here, we introduce bioinspired rotation microneedles for in vivo accurate microneedle positioning as inspired by honeybees' stingers. Read More

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Heat Treatment Promotes Ubiquitin-Mediated Proteolysis of SARS-CoV-2 RNA Polymerase and Decreases Viral Load.

Research (Wash D C) 2022 23;2022:9802969. Epub 2022 Feb 23.

Department of Public Health and Department of Hematology of First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Despite extensive efforts, COVID-19 pandemic caused by the SARS-CoV-2 virus is still at large. Vaccination is an effective approach to curb virus spread, but several variants (e.g. Read More

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February 2022

Dirac Clouds around Dilatonic Black Holes.

Research (Wash D C) 2022 4;2022:9823274. Epub 2022 Mar 4.

School of Physics and Technology, University of Jinan, 336, West Road of Nan Xinzhuang, Jinan, 250022 Shandong, China.

Dirac cloud is in absence in general relativity since the superradiance mechanism fails to work for Dirac fields. For the first time, we find a novel mechanism to support Dirac clouds, which is independent on superradiance mechanism. We study quasibound states of Dirac particles around a charged spherical black hole in dilatonic gravity. Read More

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Analytical Modeling of Flowrate and Its Maxima in Electrochemical Bioelectronics with Drug Delivery Capabilities.

Research (Wash D C) 2022 4;2022:9805932. Epub 2022 Mar 4.

Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

Flowrate control in flexible bioelectronics with targeted drug delivery capabilities is essential to ensure timely and safe delivery. For neuroscience and pharmacogenetics studies in small animals, these flexible bioelectronic systems can be tailored to deliver small drug volumes on a controlled fashion without damaging surrounding tissues from stresses induced by excessively high flowrates. The drug delivery process is realized by an electrochemical reaction that pressurizes the internal bioelectronic chambers to deform a flexible polymer membrane that pumps the drug through a network of microchannels implanted in the small animal. Read More

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Local Atomic Configuration in Pristine and A-Site Doped Silver Niobate Perovskite Antiferroelectrics.

Research (Wash D C) 2022 25;2022:9782343. Epub 2022 Feb 25.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

Antiferroelectrics have attracted increasing research interests in recent years due to both their great potential in energy storage applications and intriguing structural characteristics. However, the links between the electrical properties and structural characteristics of distorted perovskite antiferroelectrics are yet to be fully deciphered. Here, we adopt local-structure methods to elucidate the nanoscale atomic structure of AgNbO-based antiferroelectrics and their structural evolution upon La doping. Read More

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February 2022

Flexible Vertex Engineers the Controlled Assembly of Distorted Supramolecular Tetrahedral and Octahedral Cages.

Research (Wash D C) 2022 24;2022:9819343. Epub 2022 Feb 24.

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

Designing and building unique cage assemblies attract increasing interest from supramolecular chemists but remain synthetically challenging. Herein, we propose the use of a flexible vertex with adjustable angles to selectively form highly distorted tetrahedral and octahedral cages, for the first time, in which the flexible vertex forms from the synergistic effect of coordination and covalent interactions. The inherent interligand angle of the vertex can be modulated by guest anions present, which allows for the fine-tuning of different cage geometries. Read More

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February 2022

Understanding Contact Electrification at Water/Polymer Interface.

Research (Wash D C) 2022 16;2022:9861463. Epub 2022 Feb 16.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.

Contact electrification (CE) involves a complex interplay of physical interactions in realistic material systems. For this reason, scientific consensus on the qualitative and quantitative importance of different physical mechanisms on CE remains a formidable task. The CE mechanism at a water/polymer interface is a crucial challenge owing to the poor understanding of charge transfer at the atomic level. Read More

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February 2022

Multilayer 3D Chiral Folding Polymers and Their Asymmetric Catalytic Assembly.

Research (Wash D C) 2022 16;2022:9847949. Epub 2022 Feb 16.

Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA.

A novel class of polymers and oligomers of chiral folding chirality has been designed and synthesized, showing structurally compacted triple-column/multiple-layer frameworks. Both uniformed and differentiated aromatic chromophoric units were successfully constructed between naphthyl piers of this framework. Screening monomers, catalysts, and catalytic systems led to the success of asymmetric catalytic Suzuki-Miyaura polycouplings. Read More

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February 2022

Click Modification for Polysaccharides via Novel Tunnel Transmission Phenomenon in Ionic Liquids.

Research (Wash D C) 2022 10;2022:9853529. Epub 2022 Feb 10.

CAS Key Laboratory of Engineering Plastics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.

It is extremely difficult to achieve a rapid and efficient modification of natural polysaccharides, due to the intrinsic strong hydrogen bonding networks and the slow mass transfer process during the reaction process. Herein, we found a fascinating anion-tunnel transmission phenomenon in the imidazolium-based ionic liquids with carboxylate anions. A novel click esterification of natural polysaccharides thus was demonstrated under a catalyst-free condition within a very short reaction time of 15 min at 0-80°C. Read More

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February 2022

An Artificial Reflex Arc That Perceives Afferent Visual and Tactile Information and Controls Efferent Muscular Actions.

Research (Wash D C) 2022 11;2022:9851843. Epub 2022 Feb 11.

Institute of Photoelectronic Thin Film Devices and Technology of Nankai University, Tianjin 300350, China.

Neural perception and action-inspired electronics is becoming important for interactive human-machine interfaces and intelligent robots. A system that implements neuromorphic environmental information coding, synaptic signal processing, and motion control is desired. We report a neuroinspired artificial reflex arc that possesses visual and somatosensory dual afferent nerve paths and an efferent nerve path to control artificial muscles. Read More

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February 2022

Site-Specific Photochemical Reaction for Improved C=C Location Analysis of Unsaturated Lipids by Ultraviolet Photodissociation.

Research (Wash D C) 2022 12;2022:9783602. Epub 2022 Feb 12.

State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China.

Unraveling the complexity of the lipidome requires the development of novel approaches to facilitate structural identification and characterization of lipid species with isomer-level discrimination. Ultraviolet photodissociation tandem mass spectrometry (UVPD MS/MS) is a promising tool for structure determination of lipids. The sensitivity of UVPD for lipid analysis however is limited mainly due to weak absorption of UV photons by a C=C. Read More

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February 2022

Integrated Au-Nanoroded Biosensing and Regulating Platform for Photothermal Therapy of Bradyarrhythmia.

Research (Wash D C) 2022 7;2022:9854342. Epub 2022 Feb 7.

State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou 510006, China.

Bradyarrhythmia is a kind of cardiovascular disease caused by dysregulation of cardiomyocytes, which seriously threatens human life. Currently, treatment strategies of bradyarrhythmia mainly include drug therapy, surgery, or implantable cardioverter defibrillators, but these strategies are limited by drug side effect, surgical trauma, and instability of implanted devices. Here, we developed an integrated Au-nanoroded biosensing and regulating platform to investigate the photothermal therapy of cardiac bradyarrhythmia . Read More

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February 2022

Honeycomb-Like Hydrogel Microspheres for 3D Bulk Construction of Tumor Models.

Research (Wash D C) 2022 7;2022:9809763. Epub 2022 Feb 7.

Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu 215031, China.

A two-dimensional (2D) cell culture-based model is widely applied to study tumorigenic mechanisms and drug screening. However, it cannot authentically simulate the three-dimensional (3D) microenvironment of solid tumors and provide reliable and predictable data in response to , thus leading to the research illusions and failure of drug screening. In this study, honeycomb-like gelatin methacryloyl (GelMA) hydrogel microspheres are developed by synchronous photocrosslinking microfluidic technique to construct a 3D model of osteosarcoma. Read More

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February 2022

Macrophage Membrane-Camouflaged shRNA and Doxorubicin: A pH-Dependent Release System for Melanoma Chemo-Immunotherapy.

Research (Wash D C) 2022 8;2022:9768687. Epub 2022 Feb 8.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China.

Improving the efficacy of melanoma treatment remains an important global challenge. Here, we combined chemotherapy with protein tyrosine phosphatase nonreceptor type 2(Ptpn2) based immunotherapy in an effort to address this challenge. Short-hairpin RNA (shRNA) targeting Ptpn2 was coencapsulated with doxorubicin (DOX) in the cell membrane of M1 macrophages ([email protected]). Read More

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February 2022

Erratum to "Responsive Inverse Opal Scaffolds with Biomimetic Enrichment Capability for Cell Culture".

Research (Wash D C) 2022 4;2022:9850304. Epub 2022 Feb 4.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

[This corrects the article DOI: 10.34133/2019/9783793.]. Read More

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February 2022

Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection Recapitulation.

Research (Wash D C) 2022 4;2022:9819154. Epub 2022 Feb 4.

Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang 325001, China.

SARS-CoV-2 has caused a severe pneumonia pandemic worldwide with high morbidity and mortality. How to develop a preclinical model for recapitulating SARS-CoV-2 pathogenesis is still urgent and essential for the control of the pandemic. Here, we have established a 3D biomimetic alveolus-on-a-chip with mechanical strain and extracellular matrix taken into consideration. Read More

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February 2022