157,298 results match your criteria Arts in Psychotherapy[Journal]


[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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December 2018

Synthetic Methodology for Structurally defined and Unidirectional Insulated Molecular Wires via Iterative Intramolecular Slippage.

Chem Asian J 2018 Dec 7. Epub 2018 Dec 7.

Osaka Dental University, JAPAN.

Unidirectional insulated molecular wires (IMWs) were precisely synthesized via iterative cross-coupling reactions in organic solvents and subsequent intramolecular slippage transformation in aqueous solvents. This programmable synthetic procedure selectively afforded both insulated and uninsulated molecular wires bearing oligo (phenylene ethynylene) and permethylated α-cyclodextrins with well-defined conjugation lengths and supramolecular structures. High selectivity of this method was confirmed by NMR and mass spectroscopic analyses. Read More

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December 2018

Structural analysis of the inhibitory effects of polyphenols, (+)-hopeaphenol and (-)-isohopeaphenol, on human SIRT1.

Biofactors 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, Japan.

Human sirtuin 1 (hSIRT1) is a NAD -dependent deacetylase that regulates several cellular processes. Unlike resveratrol, natural polymeric phenolic compounds isolated from Vitaceae are mostly hSIRT1 inhibitors. The resveratrol tetramer, (+)-hopeaphenol ((+)-HP), and its geometric isomer, (-)-isohopeaphenol ((-)-iHP), were tested for inhibitory effects on purified hSIRT1 using a fluorescent derivative of peptide substrate p53-AMC (Fluor de Lys) and a cofactor NAD . Read More

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December 2018

Delivery of Preventive Oral Health Services by Rurality: A Cross-Sectional Analysis.

J Rural Health 2018 Dec 7. Epub 2018 Dec 7.

RAND Corporation, Pittsburgh, Pennsylvania.

Purpose: Integrating oral health care into primary care has been promoted as a strategy to increase delivery of preventive oral health services (POHS) to young children, particularly in rural areas where few dentists practice. Using a multistate sample of Medicaid claims, we examined a child's odds of receiving POHS in a medical office by county rurality.

Methods: We used 2012-2014 Medicaid Analytic extract claims data for 6,275,456 children younger than 6 years in 39 states that allowed Medicaid payment for POHS in medical offices. Read More

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December 2018

Distal radial access for coronary angiography and percutaneous coronary intervention: A state-of-the-art review.

Authors:
Thierry Corcos

Catheter Cardiovasc Interv 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, American Hospital of Paris and Hôpital Foch, Suresnes, France.

Since its introduction by Lucien Campeau three decades ago, percutaneous radial artery approach at the forearm has been shown to provide advantages over the femoral approach and has become the standard approach for coronary angiography and intervention. Though infrequent, vascular complications still remain, mainly radial artery occlusion. Therefore, a more distal radial approach at the snuffbox or at the dorsum of hand has been suggested, initially by anethesiologists for perioperative patient monitoring, and more recently by Babunashvili et al. Read More

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December 2018

Recent Progress in Electrically Rechargeable Zinc-Air Batteries.

Adv Mater 2018 Dec 9:e1805230. Epub 2018 Dec 9.

Department of Chemical Engineering, Waterloo Institute for Nanotechnology, Waterloo Institute for Sustainable Energy, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.

Over the past decade, the surging interest for higher-energy-density, cheaper, and safer battery technology has spurred tremendous research efforts in the development of improved rechargeable zinc-air batteries. Current zinc-air batteries suffer from poor energy efficiency and cycle life, owing mainly to the poor rechargeability of zinc and air electrodes. To achieve high utilization and cyclability in the zinc anode, construction of conductive porous framework through elegant optimization strategies and adaptation of alternate active material are employed. Read More

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December 2018

Partner-specific Prediction of RNA-binding Residues in Proteins: A Critical Assessment.

Proteins 2018 Dec 11. Epub 2018 Dec 11.

Bioinformatics and Genomics Graduate Program, Pennsylvania State University, University Park, Pennsylvania, USA.

RNA-protein interactions play essential roles in regulating gene expression. While some RNA-protein interactions are "specific", i.e. Read More

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December 2018
1 Read

Evaluating the performance of a deep learning-based computer-aided diagnosis (DL-CAD) system for detecting and characterizing lung nodules: Comparison with the performance of double reading by radiologists.

Thorac Cancer 2018 Dec 8. Epub 2018 Dec 8.

Department of Radiology, National Cancer Center/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

Background: The study was conducted to evaluate the performance of a state-of-the-art commercial deep learning-based computer-aided diagnosis (DL-CAD) system for detecting and characterizing pulmonary nodules.

Methods: Pulmonary nodules in 346 healthy subjects (male: female = 221:125, mean age 51 years) from a lung cancer screening program conducted from March to November 2017 were screened using a DL-CAD system and double reading independently, and their performance in nodule detection and characterization were evaluated. An expert panel combined the results of the DL-CAD system and double reading as the reference standard. Read More

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December 2018

State of the art-Patent ductus arteriosus.

Authors:

Congenit Heart Dis 2018 Sep;13(5):645

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September 2018

Ototoxicity in locally advanced head and neck cancer patients treated with induction chemotherapy followed by intermediate or high-dose cisplatin-based chemoradiotherapy.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: This study evaluated ototoxicity in locally advanced head and neck cancer patients treated in the CONDOR study with docetaxel/cisplatin/5-fluorouracil (TPF) followed by conventional radiotherapy with concomitant cisplatin 100 mg/m on days 1, 22, and 43 (cis100+RT) versus accelerated radiotherapy with concomitant cisplatin weekly 40 mg/m (cis40+ART).

Methods: Sixty-two patients were treated in this study. Audiometry was performed at baseline, during TPF, before start of chemoradiotherapy, and 1, 4, 8, and 12 months after treatment. Read More

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December 2018

Thrombotic thrombocytopenic purpura: A 5-year tertiary care centre experience.

J Clin Apher 2018 Dec 8. Epub 2018 Dec 8.

Department of Molecular Medicine and Haematology, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: Thrombotic thrombocytopenic purpura (TTP) is associated with high mortality if not managed timeously with therapeutic plasma exchange (TPE). TTP secondary to human immunodeficiency virus (HIV) infection is unique to sub-Saharan Africa. The management and outcome of TTP in the era of improved access to therapy has not been described. Read More

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December 2018

Artemisinin inhibits breast cancer-induced osteolysis by inhibiting osteoclast formation and breast cancer cell proliferation.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Research Centre for Regenerative Medicine and Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, People's Republic of China.

In addition to being used to treat malaria, artemisinin (Art) can be used as an anti-inflammatory and antitumor agent. In this study, we evaluated the effects of Art on osteoclast formation and activation and on the development of breast cancer cells in bone. To evaluate the effect of Art on osteoclast differentiation in vitro, we treated bone marrow-derived macrophages (BMMs) with various concentrations of Art and evaluated the expression of genes and proteins involved in osteoclast formation. Read More

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December 2018

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8042-8059

Gynecological Oncology, National Cancer Institute, Aviano, Italy.

Objective: Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. Read More

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November 2018

Efficacy of Invasive and Non-Invasive Brain Modulation Interventions for Addiction.

Neuropsychol Rev 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychiatry, Academic Medical Center, University of Amsterdam, PA3.227, PO box 22660, 1100DD, Amsterdam, The Netherlands.

It is important to find new treatments for addiction due to high relapse rates despite current interventions and due to expansion of the field with non-substance related addictive behaviors. Neuromodulation may provide a new type of treatment for addiction since it can directly target abnormalities in neurocircuits. We review literature on five neuromodulation techniques investigated for efficacy in substance related and behavioral addictions: transcranial direct current stimulation (tDCS), (repetitive) transcranial magnetic stimulation (rTMS), EEG, fMRI neurofeedback and deep brain stimulation (DBS) and additionally report on effects of these interventions on addiction-related cognitive processes. Read More

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December 2018
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Acceptability, Feasibility and Uptake of HPV Self-Sampling Among Immigrant Minority Women: a Focused Literature Review.

J Immigr Minor Health 2018 Dec 7. Epub 2018 Dec 7.

Centre for Research on Inner City Health, St. Michael's Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Canada.

This review uncovers the extent to which immigrant and minority women find HPV self-sampling an acceptable and feasible alternative to PAP testing for screening for cervical cancer. A focused literature review was conducted using CINAHL, Medline, Proquest and Pubmed databases to search for content relating to acceptability or feasibility of HPV self-testing for immigrant populations or minorities. 575 prospective relevant papers were included in the final analysis and 28 selected using the inclusion and exclusion criteria. Read More

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December 2018

Pharmacokinetics and bioequivalence of generic and branded abiraterone acetate tablet: a single-dose, open-label, and replicate designed study in healthy Chinese male volunteers.

Cancer Chemother Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Phase I Clinical Trial Unit, Department of Pharmacy, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.

Purpose: Abiraterone acetate is a highly variable drug and has been approved for the treatment of patients with metastatic castration-resistant prostate cancer in many countries. This study was conducted to compare the pharmacokinetic profile between the test product (abiraterone acetate tablet) and reference product ZYTIGA® (250 mg) mainly.

Methods: To overcome the high intra-subject variability of abiraterone, a two-sequence and four-period crossover study was designed to assess bioequivalence between the two products in 32 healthy male Chinese subjects under fasting conditions. Read More

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December 2018

Synthesis, Photophysical, Electrochemical and Thermal Study of Biphenyl Luminophors: Green Light Emitting Materials.

J Fluoresc 2018 Dec 10. Epub 2018 Dec 10.

D. B. F. Dayanand College of Arts and Science , Solapur, Solapur, India.

Novel luminophors of anthracene (AN) and tetracene (TN) doped biphenyl were prepared using Conventional Solid State reaction technique. Fluorescence spectroscopy, XRD, SEM, TGA-DSC and Cyclic Voltammetry techniques have been employed for photophysical, electrochemical and thermal study. The X-ray diffraction study revealed the formation of homogeneous biphenyl solid solutions with the added guests AN and TN. Read More

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December 2018

Groundwater under threat from diffuse contaminants: improving on-site sanitation, agriculture and water supply practices.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Rural Water Supply Network, Skat Foundation, St. Gallen, Switzerland.

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December 2018

Drug Use Mediates the Relationship Between Depressive Symptoms and Adherence to ART Among Recently Incarcerated People Living with HIV.

AIDS Behav 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychology, Texas Christian University, Fort Worth, TX, USA.

Depression is a known risk factor for antiretroviral therapy (ART) non-adherence, but little is known about the mechanisms explaining this relationship. Identifying these mechanisms among people living with HIV (PLHIV) after release from prison is particularly important, as individuals during this critical period are at high risk for both depression and poor ART adherence. 347 PLHIV recently released from prison in North Carolina and Texas were included in analyses to assess mediation of the relationship between depressive symptoms at 2 weeks post-release and ART adherence (assessed by unannounced telephone pill counts) at weeks 9-21 post-release by the hypothesized explanatory mechanisms of alcohol use, drug use, adherence self-efficacy, and adherence motivation (measured at weeks 6 and 14 post-release). Read More

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December 2018

DeepIsoFun: A deep domain adaptation approach to predict isoform functions.

Bioinformatics 2018 Dec 10. Epub 2018 Dec 10.

Department of Computer Science and Engineering, University of California, Riverside, CA.

Motivation: Isoforms are mRNAs produced from the same gene locus by alternative splicing and may have different functions. Although gene functions have been studied extensively, little is known about the specific functions of isoforms. Recently, some computational approaches based on multiple instance learning have been proposed to predict isoform functions from annotated gene functions and expression data, but their performance is far from being desirable primarily due to the lack of labeled training data. Read More

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December 2018

The Alzheimer's Poetry Project.

JAMA 2018 Dec;320(22):2294-2295

School of Social Work, Adelphi University, Garden City, New York.

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December 2018

A Randomized, Double-Blinded, Placebo-Controlled Trial of Sitagliptin for Reducing Inflammation and Immune Activation in Treated and Suppressed HIV Infection.

Clin Infect Dis 2018 Dec 10. Epub 2018 Dec 10.

Washington University, St. Louis, MO, USA.

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have pleotropic anti-inflammatory and immune regulatory effects in addition to their glucoregulatory actions. We evaluated inflammation and immune markers in suppressed HIV infection during treatment with the DPP-4 inhibitor sitagliptin.

Methods: Virologically suppressed adults with HIV without diabetes mellitus on stable ART with ≥100/mm 3 CD4 cells were randomized to 16 weeks of sitagliptin 100 mg/d vs. Read More

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December 2018

Improving Prediction of Protein Secondary Structure, Backbone Angles, Solvent Accessibility, and Contact Numbers by Using Predicted Contact Maps and an Ensemble of Recurrent and Residual Convolutional Neural Networks.

Bioinformatics 2018 Dec 7. Epub 2018 Dec 7.

School of Information and Communication Technology, Griffith University, Gold Coast, Australia.

Motivation: Sequence-based prediction of one dimensional structural properties of proteins has been a long-standing subproblem of protein structure prediction. Recently, prediction accuracy has been significantly improved due to the rapid expansion of protein sequence and structure libraries and advances in deep learning techniques, such as residual convolutional networks (ResNets) and Long-Short-Term Memory Cells in Bidirectional Recurrent Neural Networks (LSTM-BRNNs). Here we leverage an ensemble of LSTM-BRNN and ResNet models, together with predicted residue-residue contact maps, to continue the push towards the attainable limit of prediction for 3- and 8-state secondary structure, backbone angles (θ, τ, ϕ, and ψ), half-sphere exposure, contact numbers, and solvent accessible surface area (ASA). Read More

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December 2018

SPRING: A next-generation compressor for FASTQ data.

Bioinformatics 2018 Dec 7. Epub 2018 Dec 7.

Department of Electrical Engineering, Stanford University, Stanford, USA.

Motivation: High-Throughput Sequencing (HTS) technologies produce huge amounts of data in the form of short genomic reads, associated quality values, and read identifiers. Because of the significant structure present in these FASTQ datasets, general-purpose compressors are unable to completely exploit much of the inherent redundancy. Although there has been a lot of work on designing FASTQ compressors, most of them lack in support of one or more crucial properties, such as support for variable length reads, scalability to high coverage datasets, pairing-preserving compression and lossless compression. Read More

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December 2018

Evaluation of Exposure Assessment Tools under REACH: Part II-Higher Tier Tools.

Ann Work Expo Health 2018 Dec 9. Epub 2018 Dec 9.

Exposure Assessment Branch (EAB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV, USA.

Stoffenmanager®v4.5 and Advanced REACH Tool (ART) v1.5, two higher tier exposure assessment tools for use under REACH, were evaluated by determining accuracy and robustness. Read More

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December 2018

Decoding the Ocean's Microbiological Secrets for Marine Enzyme Biodiscovery.

FEMS Microbiol Lett 2018 Dec 5. Epub 2018 Dec 5.

School of Natural Sciences, Bangor University, Bangor, LL57 2UW, United Kingdom.

A global census of marine microbial life has been underway for several decades. During this time there have been scientific breakthroughs in estimating microbial diversity and understanding microbial functioning and ecology. It is estimated that the ocean, covering 71% of the earth's surface with its estimated volume of about 2 × 1018 m3 and an average depth of 3800 m, hosts the largest population of microbes on Earth. Read More

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December 2018

[Immunological and virological condition of adult patients with HIV infection at the beginning of antiretroviral therapy at Carlos van Buren Hospital. Comparison of 2013 and 2015 periods].

Rev Chilena Infectol 2018 ;35(3):326-328

Unidad de Infectología, Hospital Carlos van Buren, Universidad de Valparaíso, Chile.

Introduction: Anti-retroviral therapy (ART) in HIV patients has shown reduction in morbidity and mortality, and decrease in contagious risk. International recommendations include early initiation of ART, irrespectively of CD4 cell count.

Objective: To describe the impact of ART initiation in CD4 cell count and viral load at the end of the first year of HIV treatment, for patients who entered the program at 2013 and 2015. Read More

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January 2018

[Translational medicine and innovation in health: mechanisms and perspectives].

Rev Med Chil 2018 Jul;146(7):890-898

Departamento de Biología Marina, Universidad Católica del Norte, Coquimbo, Chile.

Many new discoveries in Life Sciences cannot be translated into products, services or new applications to improve human health. Translational medicine, defined as "from bench to bedside", refers to the transfer of results or new knowledge achieved in the laboratory into health innovation. We aim to review the state of art of translational medicine, its relationship with innovation processes and the different perspectives to consider. Read More

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Ferroelectric mesocrystalline BaTiO/BaBiTiO nanocomposite: formation mechanism, nanostructure, and anomalous ferroelectric response.

Nanoscale 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Engineering and Design, Kagawa University, 2217-20 Hayashi-cho, Takamatsu-shi, 761-0396 Japan.

Ferroelectric mesocrystalline nanocomposites are promising materials for the enhancement of ferroelectricity via lattice strain engineering due to their high density of heteroepitaxial interfaces. In the present study, a ferroelectric mesocrystalline BaTiO3/BaBi4Ti4O15 (BT/BBT) nanocomposite was synthesized using the layered titanate H1.07Ti1. Read More

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December 2018

Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection.

Front Immunol 2018 26;9:2735. Epub 2018 Nov 26.

Department of Pathology, New York University School of Medicine, New York, NY, United States.

Disease progression among HIV-1-infected individuals varies widely, but the mechanisms underlying this variability remains unknown. Distinct disease outcomes are the consequences of many factors working in concert, including innate and adaptive immune responses, cell-mediated and humoral immunity, and both genetic and phenotypic factors. Current data suggest that these multifaceted aspects in infected individuals should be considered as a whole, rather than as separate unique elements, and that analyses must be performed in greater detail in order to meet the requirements of personalized medicine and guide optimal vaccine design. Read More

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November 2018

An Investigation Into the Relationship Between Onset Age of Musical Lessons and Levels of Sociability in Childhood.

Front Psychol 2018 26;9:2244. Epub 2018 Nov 26.

College of Performing and Visual Arts, J. F. Oberlin University, Tokyo, Japan.

Previous studies have suggested that musical training in childhood is beneficial for sociability. However, it remains unclear how age of onset of group music lessons is associated with the late sociability of children from a long-term perspective. This study investigated associations between group music lessons conducted at a music school and children's levels of sociability by focusing on the age of onset of the lessons. Read More

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November 2018

Whole-Genome Sequences of Two sp. Strains, 4041 and 4042, Potentially Usable in Agriculture and Environmental Depollution.

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Plants and Pathogens Group, Research Institute, Land Nature and Environment, Hepia, HES-SO University of Applied Sciences and Arts Western Switzerland, Jussy, Geneva, Switzerland.

We report here the draft genome sequences of sp. strains 4041 and 4042, both of which possibly belong to the diverse Arthrobacter agilis species and are potentially usable as plant biostimulants for agriculture and as depolluting bacteria for the environment. Read More

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September 2018

Whole-Genome Sequence of Pseudomonas sp. Strain 1239, Isolated from Soil in Western France.

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Plants and Pathogens Group, Research Institute Land Nature and Environment, hepia, HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland.

We report here the draft genome sequence of Pseudomonas sp. strain 1239, a bacterium that is potentially usable as a biostimulant for agriculture or in depollution. Its genome encodes resistance to mercury, heavy metals, and several antibiotics. Read More

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September 2018

Whole-Genome Sequence of Pseudomonas aeruginosa Strain 4014, Isolated from Soil in France.

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Plants and Pathogens Group, Research Institute Land Nature and Environment, hepia, HES-SO University of Applied Sciences and Arts Western Switzerland, Jussy, Geneva, Switzerland.

We report here the draft genome sequence of strain 4014 of Pseudomonas aeruginosa, a common human pathogen, isolated from soil in France. This sequence predicts resistance to multiple antibiotics, including vancomycin. Read More

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September 2018

Whole-Genome Sequence of Pseudomonas putida Strain 1312, a Potential Biostimulant Developed for Agriculture.

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Plants and Pathogens Group, Research Institute Land Nature and Environment, hepia, HES-SO University of Applied Sciences and Arts Western Switzerland, Jussy, Geneva, Switzerland.

We report the draft genome sequence of strain 1312 of Pseudomonas putida, which could be interesting to develop as a biostimulant for agriculture and soil depollution treatments. Read More

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September 2018

Quantitative analysis of skeletal muscle by computed tomography imaging-State of the art.

J Orthop Translat 2018 Oct 28;15:91-103. Epub 2018 Oct 28.

AP-HP, Department of Radiology, Hôpital Lariboisière, Assistance Publique des Hôpitaux de Paris & Université Paris Diderot, Paris, France.

The radiological assessment of muscle properties-size, mass, density (also termed radiodensity), composition, and adipose tissue infiltration-is fundamental in muscle diseases. More recently, it also became obvious that muscle atrophy, also termed muscle wasting, is caused by or associated with many other diseases or conditions, such as inactivity, malnutrition, chronic obstructive pulmonary disorder, cancer-associated cachexia, diabetes, renal and cardiac failure, and sarcopenia and even potentially with osteoporotic hip fracture. Several techniques have been developed to quantify muscle morphology and function. Read More

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October 2018

Structural plasticity in root-fungal symbioses: diverse interactions lead to improved plant fitness.

PeerJ 2018 4;6:e6030. Epub 2018 Dec 4.

Centre for Agri-Environmental Research & Soil Research Centre, School of Agriculture Policy and Development, University of Reading, Berkshire, United Kingdom.

Root-fungal symbioses such as mycorrhizas and endophytes are key components of terrestrial ecosystems. Diverse in trophy habits (obligate, facultative or hemi-biotrophs) and symbiotic relations (from mutualism to parasitism), these associations also show great variability in their root colonization and nutritional strategies. Specialized interface structures such as arbuscules and Hartig nets are formed by certain associations while others are restricted to non-specialized intercellular or intracellular hyphae in roots. Read More

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December 2018

Nox2 Activity Is Required in Obesity-Mediated Alteration of Bone Remodeling.

Oxid Med Cell Longev 2018 8;2018:6054361. Epub 2018 Nov 8.

Department of Biomedical Sciences, College of Health Sciences, Qatar University, PO Box 2713 Doha, Qatar.

Despite increasing evidence suggesting a role for NADPH oxidases (Nox) in bone pathophysiology, whether Nox enzymes contribute to obesity-mediated bone remodeling remains to be clearly elucidated. Nox2 is one of the predominant Nox enzymes expressed in the bone marrow microenvironment and is a major source of ROS generation during inflammatory processes. It is also well recognized that a high-fat diet (HFD) induces obesity, which negatively impacts bone remodeling. Read More

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November 2018

SFPEL-LPI: Sequence-based feature projection ensemble learning for predicting LncRNA-protein interactions.

PLoS Comput Biol 2018 Dec 11;14(12):e1006616. Epub 2018 Dec 11.

School of Computer Science, Wuhan University, Wuhan, China.

LncRNA-protein interactions play important roles in post-transcriptional gene regulation, poly-adenylation, splicing and translation. Identification of lncRNA-protein interactions helps to understand lncRNA-related activities. Existing computational methods utilize multiple lncRNA features or multiple protein features to predict lncRNA-protein interactions, but features are not available for all lncRNAs or proteins; most of existing methods are not capable of predicting interacting proteins (or lncRNAs) for new lncRNAs (or proteins), which don't have known interactions. Read More

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December 2018

A Mechanistic View of the Main Current Issues in Photocatalytic CO2 Reduction.

J Phys Chem Lett 2018 Dec 11. Epub 2018 Dec 11.

After 40 years of research on photocatalytic CO2 reduction, there are still many unknowns about its mechanistic aspects even for the most common TiO2-based photocatalytic systems. These uncertainties include the pathways inducing visible-light activity in wide-band-gap semiconductors; the charge transfer between semiconductors and plasmonic metal nanoparticles; the unambiguous determination of the origin of C-bearing products; the very first step in the activation of the CO2 molecule; the factors determining the selectivity; the reasons of photocatalyst deactivation; the closure of the catalytic cycle by the hole-scavenging reagent; and the detailed reaction pathways and the most suitable techniques for their determination. This perspective discusses these controversial issues based on the most relevant investigations reported so far. Read More

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December 2018

A Predictive Model for Guillain-Barré Syndrome Based on Ensemble Methods.

Comput Intell Neurosci 2018 5;2018:1576927. Epub 2018 Nov 5.

División Académica de Informática y Sistemas, Universidad Juárez Autónoma de Tabasco, Tabasco, Mexico.

Nowadays, Machine Learning methods have proven to be highly effective on the identification of various types of diseases, in the form of predictive models. Guillain-Barré syndrome (GBS) is a potentially fatal autoimmune neurological disorder that has barely been studied with computational techniques and few predictive models have been proposed. In a previous study, single classifiers were successfully used to build a predictive model. Read More

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November 2018

Aging with HIV: what effect on mortality and loss to follow-up in the course of antiretroviral therapy? The IeDEA West Africa Cohort Collaboration.

HIV AIDS (Auckl) 2018 16;10:239-252. Epub 2018 Nov 16.

INSERM, Centre INSERM U1219-Epidémiologie-Biostatistique, Bordeaux, France,

Background: Reporting mortality and lost to follow-up (LTFU) by age is essential as older HIV-positive patients might be at risk of long-term effects of living with HIV and/or taking antiretroviral therapy (ART). As age effects might not be linear and might impact HIV outcomes in the oldest more severely, people living with HIV (PLHIV) aged 50-59 years and PLHIV aged >60 years were considered separately.

Setting: Seventeen adult HIV/AIDS clinics spread over nine countries in West Africa. Read More

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November 2018

Selenium as a pleiotropic agent for medical discovery and drug delivery.

Int J Nanomedicine 2018 14;13:7473-7490. Epub 2018 Nov 14.

Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou, China,

Selenium as a biologically active element lends much support to health maintenance and disease prevention. It is now presenting pleiotropic effects on therapy and drug delivery. In this study, a profiling on the physiological functions, therapeutic significances, clinical/preclinical performances, and biomedical and drug delivery applications of selenium in different modalities was carried out. Read More

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November 2018

Wavelet analysis of oximetry recordings to assist in the automated detection of moderate-to-severe pediatric sleep apnea-hypopnea syndrome.

PLoS One 2018 7;13(12):e0208502. Epub 2018 Dec 7.

Biomedical Engineering Group, Universidad de Valladolid, Valladolid, Spain.

Background: The gold standard for pediatric sleep apnea hypopnea syndrome (SAHS) is overnight polysomnography, which has several limitations. Thus, simplified diagnosis techniques become necessary.

Objective: The aim of this study is twofold: (i) to analyze the blood oxygen saturation (SpO2) signal from nocturnal oximetry by means of features from the wavelet transform in order to characterize pediatric SAHS; (ii) to evaluate the usefulness of the extracted features to assist in the detection of pediatric SAHS. Read More

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December 2018

The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism.

PLoS Genet 2018 Dec 7;14(12):e1007840. Epub 2018 Dec 7.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands.

Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration. Studies in vertebrate model systems have suggested that Vangl and Pk may also inhibit signaling through the canonical Wnt/β-catenin pathway, but the functional significance of this potential cross-talk is unclear. In the nematode C. Read More

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December 2018

Sub-picosecond photon-efficient 3D imaging using single-photon sensors.

Sci Rep 2018 Dec 7;8(1):17726. Epub 2018 Dec 7.

Stanford University, Department of Electrical Engineering, Stanford, USA.

Active 3D imaging systems have broad applications across disciplines, including biological imaging, remote sensing and robotics. Applications in these domains require fast acquisition times, high timing accuracy, and high detection sensitivity. Single-photon avalanche diodes (SPADs) have emerged as one of the most promising detector technologies to achieve all of these requirements. Read More

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December 2018

Circadian clocks and insulin resistance.

Nat Rev Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and various peripheral tissue clocks. The circadian timing system is responsible for the coordination of many daily processes, including the daily rhythm in human glucose metabolism. Read More

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December 2018

Atmospheric CO captured by biogenic polyamines is transferred as a possible substrate to Rubisco for the carboxylation reaction.

Sci Rep 2018 Dec 7;8(1):17724. Epub 2018 Dec 7.

Kitasato University School of Marine Biosciences, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0373, Japan.

Biogenic polyamines are involved in a wide range of plant cellular processes, including cell division, morphogenesis and stress responses. However, the exact roles of biogenic polyamines are not well understood. We recently reported that biogenic polyamines that have multiple amino groups can react with CO and accelerate calcium carbonate formation in seawater. Read More

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December 2018