349,299 results match your criteria Artificial cells nanomedicine and biotechnology[Journal]


How can endoscopists adapt and collaborate with artificial intelligence for early gastric cancer detection?

Dig Endosc 2020 May 26. Epub 2020 May 26.

Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

Early detection is essential to improve the prognosis and mortality of gastric cancer, particularly in countries with high incidence of gastric cancer such as Japan and Korea. Endoscopy has been recently accepted as a primary tool in population-based gastric cancer screening . Early detection also allows for minimally invasive endoscopic resection which has been shown to have excellent overall survival comparable to gastrectomy, while preserving stomach function. Read More

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http://dx.doi.org/10.1111/den.13751DOI Listing

Development and validation of explainable AI-based decision-supporting tool for prostate biopsy.

BJU Int 2020 May 26. Epub 2020 May 26.

Department of Urology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, South Korea.

Objectives: To develop and validate a risk calculator for prostate cancer (PC) and clinically significant PC (csPC) using explainable artificial intelligence (XAI).

Materials And Methods: We used data of 3791 patients to develop and validate the risk calculator. We initially divided the data into development and validation sets. Read More

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http://dx.doi.org/10.1111/bju.15122DOI Listing

Theoretical and Experimental Study of Compression Effects on Structural Relaxation of Glass-Forming Liquids.

ACS Omega 2020 May 5;5(19):11035-11042. Epub 2020 May 5.

Department of Nanotechnology for Sustainable Energy, School of Science and Technology, Kwansei Gakuin University, Sanda 669-1337, Hyogo, Japan.

We develop the elastically collective nonlinear Langevin equation theory of bulk relaxation of glass-forming liquids to investigate molecular mobility under compression conditions. The applied pressure restricts more molecular motion and therefore significantly slows down the molecular dynamics when increasing the pressure. We quantitatively determine the temperature and pressure dependence of the structural relaxation time. Read More

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http://dx.doi.org/10.1021/acsomega.0c00860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241026PMC

Comparison of different microCT-based morphology assessment tools using human trabecular bone.

Bone Rep 2020 Jun 4;12:100261. Epub 2020 May 4.

Institute for Lightweight Design and Structural Biomechanics, TU-Wien, Vienna, Austria.

MicroCT-based morphological parameters are often used to quantify the structural properties of trabecular bone. Various software tools are available for calculating these parameters. Studies that examine the comparability of their results are rare. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235944PMC

Effect of Essential Oil Supplementation on the Advanced Parameters of Mobility and on the Integrity of Human Sperm DNA.

Int J Reprod Med 2020 13;2020:1230274. Epub 2020 May 13.

Laboratory of Physiopathology, Genetics Molecular and Biotechnology (PGMB), Faculty of Sciences Ain Chock, Research Center Health and Biotechnology, University Hassan II of Casablanca, Morocco.

The reduced sperm mobility is one of the most important causes of male infertility. Several reports have indicated that the treatment of subnormal sperm samples with certain agents prior to artificial insemination significantly improves the fertilizing potential of sperm. We have among others some stimulants such as pentoxifylline, relaxin, prostaglandin E, and diltiazem. Read More

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http://dx.doi.org/10.1155/2020/1230274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243007PMC

Au/Pb Interface Allows the Methane Formation Pathway in Carbon Dioxide Electroreduction.

ACS Catal 2020 May 14;10(10):5681-5690. Epub 2020 Apr 14.

Department of Physical Chemistry and Materials Science, Interdisciplinary Excellence Centre, University of Szeged, Rerrich Square 1., Szeged H-6720, Hungary.

The electrochemical conversion of carbon dioxide (CO) to high-value chemicals is an attractive approach to create an artificial carbon cycle. Tuning the activity and product selectivity while maintaining long-term stability, however, remains a significant challenge. Here, we study a series of Au-Pb bimetallic electrocatalysts with different Au/Pb interfaces, generating carbon monoxide (CO), formic acid (HCOOH), and methane (CH) as CO reduction products. Read More

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http://dx.doi.org/10.1021/acscatal.0c00749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236132PMC

Intelligent Diagnosis of Heart Murmurs in Children with Congenital Heart Disease.

J Healthc Eng 2020 9;2020:9640821. Epub 2020 May 9.

Department of Mechanical Engineering, Texas Tech University, Lubbock, TX 79409, USA.

Heart auscultation is a convenient tool for early diagnosis of heart diseases and is being developed to be an intelligent tool used in online medicine. Currently, there are few studies on intelligent diagnosis of pediatric murmurs due to congenital heart disease (CHD). The purpose of the study was to develop a method of intelligent diagnosis of pediatric CHD murmurs. Read More

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http://dx.doi.org/10.1155/2020/9640821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238385PMC

Adhesion of Hydroxyapatite Nanoparticles to Dental Materials under Oral Conditions.

Scanning 2020 5;2020:6065739. Epub 2020 May 5.

Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University Hospital, D-66421 Homburg, Saarland, Germany.

Hydroxyapatite nanoparticles (nano-HAP) are receiving considerable attention for dental applications, and their adhesion to enamel is well established. However, there are no reports concerning the effects of HAP on other dental materials, and most of the studies in this field are based on designs, neglecting the salivary pellicle-apatite interactions. Thus, this pilot study aims to evaluate the effects of three hydroxyapatite-based solutions and their interactions with different dental material surfaces under oral conditions. Read More

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http://dx.doi.org/10.1155/2020/6065739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222588PMC

Child-Robot Relationship Formation: A Narrative Review of Empirical Research.

Int J Soc Robot 2020 3;12(2):325-344. Epub 2019 Jul 3.

Amsterdam School of Communication Research (ASCoR), University of Amsterdam, P.O. Box 1579, 1001 NG Amsterdam, The Netherlands.

This narrative review aimed to elucidate which robot-related characteristics predict relationship formation between typically-developing children and social robots in terms of closeness and trust. Moreover, we wanted to know to what extent relationship formation can be explained by children's experiential and cognitive states during interaction with a robot. We reviewed 86 journal articles and conference proceedings published between 2000 and 2017. Read More

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http://dx.doi.org/10.1007/s12369-019-00569-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235061PMC

A Novel Radial Basis Neural Network-Leveraged Fast Training Method for Identifying Organs in MR Images.

Comput Math Methods Med 2020 5;2020:4519483. Epub 2020 May 5.

Department of Radiology and Case Center for Imaging Research, University Hospitals, Case Western Reserve University, Cleveland, OH 44106, USA.

We propose a new method for fast organ classification and segmentation of abdominal magnetic resonance (MR) images. Magnetic resonance imaging (MRI) is a new type of high-tech imaging examination fashion in recent years. Recognition of specific target areas (organs) based on MR images is one of the key issues in computer-aided diagnosis of medical images. Read More

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http://dx.doi.org/10.1155/2020/4519483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222610PMC

Screening of Sacrificial Excipients for Arresting Devitrification of Itraconazole from Solid Dispersion.

Turk J Pharm Sci 2019 Jun 27;16(2):211-219. Epub 2019 Mar 27.

Gujarat Technological University, Anand Pharmacy College, Anand, Gujarat, India.

Objectives: The aim of the present investigation was to develop a solid dispersion of itraconazole (ITR) using sacrificial excipients like pregelatinized starch and spray-dried lactose alongside hydroxypropyl methylcellulose and Poloxamer 188, thereby arresting the conversion of the amorphous form of ITR to crystalline form, and to assess the dissolution stability of an amorphous form of the drug during short-term storage.

Materials And Methods: ITR-loaded solid dispersions were prepared by kneading. Formulation optimization was achieved by using a 2 full factorial design on the basis of cumulative percent drug released at t, t, and t min. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.54871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227971PMC

Quantitative Structure-Activity Relationship Analysis of Selective Rho Kinase Inhibitors as Neuro-regenerator Agents.

Turk J Pharm Sci 2019 Jun 27;16(2):141-154. Epub 2019 Mar 27.

Banasthali University, Faculty of Pharmacy, Department of Pharmacy, Rajasthan, India.

Objectives: To understand the role of Rho (serine/threonine) kinases in the treatment of neurological segments, attempts have been made to find potent inhibitors of Rho enzyme by a 2D quantitative structure-activity relationship (QSAR) model.

Materials And Methods: QSAR studies were executed on urea-based scaffolds from aniline and benzylamine analogues, which were aligned for generation of a chemometric-based model. Multivariate statistical approaches were applied including linear and nonlinear analysis such as multiple linear regression, partial least square and artificial neural network for the generation of model, and also an application of () absorption, distribution, metabolism, excretion studies was performed to ascertain the novelty and drug-like properties of the intended molecules. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.70288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227969PMC

Sparsity through evolutionary pruning prevents neuronal networks from overfitting.

Neural Netw 2020 May 11;128:305-312. Epub 2020 May 11.

Neuroscience Lab, Experimental Otolaryngology, University Hospital Erlangen, Germany; Cognitive Computational Neuroscience Group at the Chair of English Philology and Linguistics, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany. Electronic address:

Modern Machine learning techniques take advantage of the exponentially rising calculation power in new generation processor units. Thus, the number of parameters which are trained to solve complex tasks was highly increased over the last decades. However, still the networks fail - in contrast to our brain - to develop general intelligence in the sense of being able to solve several complex tasks with only one network architecture. Read More

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http://dx.doi.org/10.1016/j.neunet.2020.05.007DOI Listing

Generalized norm for existence, uniqueness and stability of Hopfield neural networks with discrete and distributed delays.

Neural Netw 2020 May 20;128:288-293. Epub 2020 May 20.

Department of Science, Texas A&M University at Qatar, Doha 23874, Qatar.

In this paper, the existence, uniqueness and stability criteria of solutions for Hopfield neural networks with discrete and distributed delays (DDD HNNs) are investigated by the definitions of three kinds of generalized norm (ξ-norm). A general DDD HNN model is firstly introduced, where the discrete delays τ(t) are asynchronous time-varying delays. Then, {ξ,1}-norm, {ξ,2}-norm and {ξ,∞}-norm are successively used to derive the existence, uniqueness and stability criteria of solutions for the DDD HNNs. Read More

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http://dx.doi.org/10.1016/j.neunet.2020.05.014DOI Listing

Active source localization in wave guides based on machine learning.

Ultrasonics 2020 Apr 18;106:106144. Epub 2020 Apr 18.

Institute of General Mechanics, RWTH Aachen University, Templergraben 64, 52062 Aachen, Germany.

In the present work, an active source localization strategy is proposed. The presence of active sources in a waveguide can have several reasons, such as crack initiation or internal friction. In this study, the active source is represented by an impact event. Read More

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http://dx.doi.org/10.1016/j.ultras.2020.106144DOI Listing

Prostaglandin F influences pre-ovulatory follicle characteristics and pregnancy per AI in anovular dairy cows.

Theriogenology 2020 May 6;153:122-132. Epub 2020 May 6.

Department of Animal Sciences, University of Florida, United States; DH Barron Reproductive and Perinatal Biology Research Program, University of Florida, 32611-0910, United States. Electronic address:

Objectives were to determine the effects of a dose of PGF administered 2 days before timed artificial insemination (AI) on LH pulsatility, characteristics of the pre-ovulatory follicle, and pregnancy per artificial insemination (P/AI) in anovular dairy cows, particularly in cows not subjected to hyperthermia. In experiment 1, 2,011 lactating Holstein cows had ovaries scanned by ultrasound to determine corpus luteum (CL) presence and only those without a CL in two consecutive exams were enrolled (n = 437). Cows had the estrous cycle synchronized with an estradiol-progesterone based protocol starting on experiment Day -11 and timed AI on Day 0. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.04.038DOI Listing

The interplay of spatial organization and biochemistry in building blocks of cellular signalling pathways.

J R Soc Interface 2020 May 27;17(166):20200251. Epub 2020 May 27.

Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Biochemical pathways and networks are central to cellular information processing. While a broad range of studies have dissected multiple aspects of information processing in biochemical pathways, the effect of spatial organization remains much less understood. It is clear that space is central to intracellular organization, plays important roles in cellular information processing and has been exploited in evolution; additionally, it is being increasingly exploited in synthetic biology through the development of artificial compartments, in a variety of ways. Read More

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http://dx.doi.org/10.1098/rsif.2020.0251DOI Listing

The anti-ageing effects of a natural peptide discovered by Artificial Intelligence.

Int J Cosmet Sci 2020 May 26. Epub 2020 May 26.

Nuritas Ltd, Joshua Dawson House, Dawson St, Dublin 2, D02 RY95, Dublin, Ireland.

Objective: As skin ages, impaired extracellular matrix (ECM) protein synthesis and increased action of degradative enzymes manifests as atrophy, wrinkling and laxity. There is mounting evidence for the functional role of exogenous peptides across many areas, including in offsetting the effects of cutaneous ageing. Here, using an artificial intelligence (AI) approach, we identified peptide RTE62G (pep_RTE62G), a naturally occurring, unmodified peptide with ECM stimulatory properties. Read More

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http://dx.doi.org/10.1111/ics.12635DOI Listing

Visual Speech Recognition: Improving Speech Perception in Noise through Artificial Intelligence.

Otolaryngol Head Neck Surg 2020 May 26:194599820924331. Epub 2020 May 26.

Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati/Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Objectives: To compare speech perception (SP) in noise for normal-hearing (NH) individuals and individuals with hearing loss (IWHL) and to demonstrate improvements in SP with use of a visual speech recognition program (VSRP).

Study Design: Single-institution prospective study.

Setting: Tertiary referral center. Read More

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http://dx.doi.org/10.1177/0194599820924331DOI Listing

Isotope and chemical assessment of natural water in the Jaffna Peninsula in northern Sri Lanka for groundwater development aspects.

Isotopes Environ Health Stud 2020 May 26:1-15. Epub 2020 May 26.

Isotope Hydrology Section, Sri Lanka Atomic Energy Board (SLAEB), Orugodawatta, Sri Lanka.

The demand for fresh groundwater in the Jaffna peninsula in northern Sri Lanka, has been increasing as the only water source for domestic and agricultural needs. Isotopic and hydro-chemical assessment on groundwater recharge and quality was done with the objective of assisting groundwater management plans. Water samples were collected in pre and post monsoon periods for isotope analyses (H, O and H) and major ions. Read More

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http://dx.doi.org/10.1080/10256016.2020.1766457DOI Listing

Artificial Biosystem for Modulation of Interactions between Antigen-Presenting Cells and T Cells.

Adv Biosyst 2020 May 26:e2000039. Epub 2020 May 26.

Laboratory for Immuno Bioengineering Research and Applications, Division of Engineering, New York University Abu Dhabi, Abu Dhabi, UAE.

T cell activation is triggered by signal molecules on the surface of antigen-presenting cells (APC) and subsequent exertion of cellular forces. Deciphering the biomechanical and biochemical signals in this complex process is of interest and will contribute to an improvement in immunotherapy strategies. To address underlying questions, coculture and biomimetic models are established. Read More

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http://dx.doi.org/10.1002/adbi.202000039DOI Listing

Female neurogenic stress urinary incontinence.

Curr Opin Urol 2020 May 20. Epub 2020 May 20.

Department of Urology, HUP La Fe, Valencia, Spain.

Purpose Of Review: The aim of this article is to look into recent updates on the management of neurogenic stress urinary incontinence (NSUI) in adult females.

Recent Findings: Recently, a small number of studies have investigated different surgical modalities in treatment of NSUI in adult females including artificial urinary sphincter (AUS), suburethral tapes (SUT) and adjustable slings and urethral bulking agents. Up to 70% of neurogenic patients who received AUS implants are continent and have not required surgical revision over a 20-year follow-up period. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000785DOI Listing

Is Deep Learning On Par with Human Observers for Detection of Radiographically Visible and Occult Fractures of the Scaphoid?

Clin Orthop Relat Res 2020 May 19. Epub 2020 May 19.

D. W. G. Langerhuizen, S. J. Janssen, G. M. M. J. Kerkhoffs, Department of Orthopaedic Surgery, Amsterdam Movement Sciences (AMS), Amsterdam University Medical Centre, Amsterdam, The Netherlands A. E. J. Bulstra, R. L. Jaarsma, J. N. Doornberg, Flinders University, Department of Orthopaedic & Trauma Surgery, Flinders Medical Centre, Adelaide, Australia D. Ring, Department of Surgery and Perioperative Care, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.

Background: Preliminary experience suggests that deep learning algorithms are nearly as good as humans in detecting common, displaced, and relatively obvious fractures (such as, distal radius or hip fractures). However, it is not known whether this also is true for subtle or relatively nondisplaced fractures that are often difficult to see on radiographs, such as scaphoid fractures.

Questions/purposes: (1) What is the diagnostic accuracy, sensitivity, and specificity of a deep learning algorithm in detecting radiographically visible and occult scaphoid fractures using four radiographic imaging views? (2) Does adding patient demographic (age and sex) information improve the diagnostic performance of the deep learning algorithm? (3) Are orthopaedic surgeons better at diagnostic accuracy, sensitivity, and specificity compared with deep learning? (4) What is the interobserver reliability among five human observers and between human consensus and deep learning algorithm?

Methods: We retrospectively searched the picture archiving and communication system (PACS) to identify 300 patients with a radiographic scaphoid series, until we had 150 fractures (127 visible on radiographs and 23 only visible on MRI) and 150 non-fractures with a corresponding CT or MRI as the reference standard for fracture diagnosis. Read More

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http://dx.doi.org/10.1097/CORR.0000000000001318DOI Listing

Optical Coherence Tomography-based Diabetic Macula Edema Screening with Artificial Intelligence.

J Chin Med Assoc 2020 May 20. Epub 2020 May 20.

Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: Optical coherence tomography (OCT) is considered as a sensitive and non-invasive tool to evaluate the macular lesions. In patients with diabetes mellitus (DM), the existence of diabetic macular edema (DME) can cause significant vision impairment and further intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) is needed. However, the increasing number of DM patients makes it a big burden for clinicians to manually determine whether DME exists in the OCT images. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000351DOI Listing

Artificial neural network and bioavailability of the immunosuppression drug.

Curr Opin Organ Transplant 2020 May 20. Epub 2020 May 20.

Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Purpose Of Review: The success of organ transplant is determined by number of demographic, clinical, immunological and genetic variables. Artificial intelligence tools, such as artificial neural networks (ANNs) or classification and regression trees (CART) can handle multiple independent variables and predict the dependent variables by deducing the complex nonlinear relationships between variables.

Recent Findings: In the last two decades, several researchers employed these tools to identify donor-recipient matching pairs, to optimize immunosuppressant doses, to predict allograft survival and to minimize adverse drug reactions. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000770DOI Listing

An Exploration Into the Use of a Chatbot for Patients With Inflammatory Bowel Diseases: Retrospective Cohort Study.

J Med Internet Res 2020 May 26;22(5):e15589. Epub 2020 May 26.

Vatche and Tamar Manoukian Division of Digestive Diseases, UCLA Center for Inflammatory Bowel Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.

Background: The emergence of chatbots in health care is fast approaching. Data on the feasibility of chatbots for chronic disease management are scarce.

Objective: This study aimed to explore the feasibility of utilizing natural language processing (NLP) for the categorization of electronic dialog data of patients with inflammatory bowel diseases (IBD) for use in the development of a chatbot. Read More

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http://dx.doi.org/10.2196/15589DOI Listing

Artificial Intelligence-Assisted System in Postoperative Follow-up of Orthopedic Patients: Exploratory Quantitative and Qualitative Study.

J Med Internet Res 2020 May 26;22(5):e16896. Epub 2020 May 26.

Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Background: Patient follow-up is an essential part of hospital ward management. With the development of deep learning algorithms, individual follow-up assignments might be completed by artificial intelligence (AI). We developed an AI-assisted follow-up conversational agent that can simulate the human voice and select an appropriate follow-up time for quantitative, automatic, and personalized patient follow-up. Read More

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http://dx.doi.org/10.2196/16896DOI Listing

Outlier-Resistant Remote State Estimation for Recurrent Neural Networks With Mixed Time-Delays.

IEEE Trans Neural Netw Learn Syst 2020 May 18;PP. Epub 2020 May 18.

In this brief, a new outlier-resistant state estimation (SE) problem is addressed for a class of recurrent neural networks (RNNs) with mixed time-delays. The mixed time delays comprise both discrete and distributed delays that occur frequently in signal transmissions among artificial neurons. Measurement outputs are sometimes subject to abnormal disturbances (resulting probably from sensor aging/outages/faults/failures and unpredictable environmental changes) leading to measurement outliers that would deteriorate the estimation performance if directly taken into the innovation in the estimator design. Read More

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http://dx.doi.org/10.1109/TNNLS.2020.2991151DOI Listing

Reachable Set Estimation for Neural Network Control Systems: A Simulation-Guided Approach.

IEEE Trans Neural Netw Learn Syst 2020 May 14;PP. Epub 2020 May 14.

The vulnerability of artificial intelligence (AI) and machine learning (ML) against adversarial disturbances and attacks significantly restricts their applicability in safety-critical systems including cyber-physical systems (CPS) equipped with neural network components at various stages of sensing and control. This article addresses the reachable set estimation and safety verification problems for dynamical systems embedded with neural network components serving as feedback controllers. The closed-loop system can be abstracted in the form of a continuous-time sampled-data system under the control of a neural network controller. Read More

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http://dx.doi.org/10.1109/TNNLS.2020.2991090DOI Listing

An up-to-date overview of computational polypharmacology in modern drug discovery.

Expert Opin Drug Discov 2020 May 26:1-20. Epub 2020 May 26.

Intelligent Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.

Introduction: In recent years, computational polypharmacology has gained significant attention to study the promiscuous nature of drugs. Despite tremendous challenges, community-wide efforts have led to a variety of novel approaches for predicting drug polypharmacology. In particular, some rapid advances using machine learning and artificial intelligence have been reported with great success. Read More

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http://dx.doi.org/10.1080/17460441.2020.1767063DOI Listing

Application of a Backpropagation Artificial Neural Network in Predicting Plasma Concentration and Pharmacokinetic Parameters of Oral Single-Dose Rosuvastatin in Healthy Subjects.

Clin Pharmacol Drug Dev 2020 May 26. Epub 2020 May 26.

Center of Clinical Pharmacology, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.

A backpropagation artificial neural network (BPANN) model was established for the prediction of the plasma concentration and pharmacokinetic parameters of rosuvastatin (RVST) in healthy subjects. The data (demographic characteristics and results of clinical laboratory tests) were collected from 4 bioequivalence studies using reference 10-mg RVST calcium tablets. After the data were cleaned using extreme gradient boosting, 13 important factors were extracted to construct the BPANN model. Read More

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http://dx.doi.org/10.1002/cpdd.809DOI Listing

Evolution of Bio-Inspired Artificial Synapses: Materials, Structures, and Mechanisms.

Small 2020 May 26:e2000041. Epub 2020 May 26.

Institute of Photoelectronic Thin Film Devices and Technology, Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin, College of Electronic Information and Optical Engineering, Nankai University, Tianjin, 300350, P. R. China.

Artificial synapses (ASs) are electronic devices emulating important functions of biological synapses, which are essential building blocks of artificial neuromorphic networks for brain-inspired computing. A human brain consists of several quadrillion synapses for information storage and processing, and massively parallel computation. Neuromorphic systems require ASs to mimic biological synaptic functions, such as paired-pulse facilitation, short-term potentiation, long-term potentiation, spatiotemporally-correlated signal processing, and spike-timing-dependent plasticity, etc. Read More

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http://dx.doi.org/10.1002/smll.202000041DOI Listing

Invasion and Defense Interactions between Enzyme-Active Liquid Coacervate Protocells and Living Cells.

Small 2020 May 26:e2002073. Epub 2020 May 26.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, 410082, P. R. China.

The design and construction of mutual interaction models between artificial microsystems and living cells have the potential to open a wide range of novel applications in biomedical and biomimetic technologies. In this study, an artificial form of invasion-defense mutual interactions is established in a community of glucose oxidase (GOx)-containing liquid coacervate microdroplets and living cells, which interact via enzyme-mediated reactive oxygen species (ROS) damage. The enzyme-containing coacervate microdroplets, formed via liquid-liquid phase separation, act as invader protocells to electrostatically bind with the host HepG2 cell, resulting in assimilation. Read More

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http://dx.doi.org/10.1002/smll.202002073DOI Listing

Photoinduced water oxidation in pyrimidine-water clusters: a combined experimental and theoretical study.

Phys Chem Chem Phys 2020 May 26. Epub 2020 May 26.

Department of Chemistry, Technical University of Munich, Garching, Germany.

The photocatalytic oxidation of water with molecular or polymeric N-heterocyclic chromophores is a topic of high current interest in the context of artificial photosynthesis, that is, the conversion of solar energy to clean fuels. Hydrogen-bonded clusters of N-heterocycles with water molecules in a molecular beam are simple model systems for which the basic mechanisms of photochemical water oxidation can be studied under well-defined conditions. In this work, we explored the photoinduced H-atom transfer reaction in pyrimidine-water clusters yielding pyrimidinyl and hydroxyl radicals with laser spectroscopy, mass spectrometry and trajectory-based ab initio molecular dynamics simulations. Read More

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http://dx.doi.org/10.1039/d0cp01562hDOI Listing

Placental MRI: Effect of maternal position and uterine contractions on placental BOLD MRI measurements.

Placenta 2020 Apr 22;95:69-77. Epub 2020 Apr 22.

Maternal-Fetal Medicine, Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.

Introduction: Before using blood-oxygen-level-dependent magnetic resonance imaging (BOLD MRI) during maternal hyperoxia as a method to detect individual placental dysfunction, it is necessary to understand spatiotemporal variations that represent normal placental function. We investigated the effect of maternal position and Braxton-Hicks contractions on estimates obtained from BOLD MRI of the placenta during maternal hyperoxia.

Methods: For 24 uncomplicated singleton pregnancies (gestational age 27-36 weeks), two separate BOLD MRI datasets were acquired, one in the supine and one in the left lateral maternal position. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.04.008DOI Listing

One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C-H Activation and Relay Diels-Alder Reaction.

Org Lett 2020 May 26. Epub 2020 May 26.

The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

An efficient one-pot synthesis of multisubstituted 9,10-dihydrophenanthrenes from easily available 2-arylazaarenes and cyclohexadienone-tethered terminal alkynes (1,6-enynes) has been successfully achieved. This domino reaction proceeded smoothly through Cp*Rh(III)-catalyzed C-H activation, direct protonation of alkenyl-Rh intermediates, intramolecular Diels-Alder reaction, alkene isomerization, subsequent ring-opening aromatization, and acetylation. This strategy was pot-economical and tolerated a wide range of functional groups. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01339DOI Listing

Complication rates among women undergoing preventive mastectomy: An Austrian registry.

Breast J 2020 May 25. Epub 2020 May 25.

Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.

Germline variations in the BRCA-1 and BRCA-2 genes are associated with an increased risk of breast cancer. These variants are found in 5% of all breast cancer cases. Prophylactic mastectomy is the most effective risk-reducing method and shows high rates of patient satisfaction and acceptance. Read More

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http://dx.doi.org/10.1111/tbj.13877DOI Listing

Ostrich ejaculate characteristics and male libido around equinox and solstice dates.

Trop Anim Health Prod 2020 May 25. Epub 2020 May 25.

Department of Animal Sciences, University of Stellenbosch, Private Bag X1, Matieland, 7602, South Africa.

The study evaluated the effect of time of the year in which changes in photoperiod occurs on ostrich semen characteristics and male libido. Semen was collected for 5 days before, on and 5 days after winter solstice (21 June 2016), spring equinox (22 September 2016), summer solstice (21 December 2016) and autumn equinox (20 March 2017) in the southern hemisphere. Semen was collected from 10 South African Black ostrich males (average age ± standard deviation; 4. Read More

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http://dx.doi.org/10.1007/s11250-020-02299-2DOI Listing

Role of biological Data Mining and Machine Learning Techniques in Detecting and Diagnosing the Novel Coronavirus (COVID-19): A Systematic Review.

J Med Syst 2020 May 25;44(7):122. Epub 2020 May 25.

Information Technology Department, College of Applied Sciences, Ministry of Higher Education, Muscat, Iraq.

Coronaviruses (CoVs) are a large family of viruses that are common in many animal species, including camels, cattle, cats and bats. Animal CoVs, such as Middle East respiratory syndrome-CoV, severe acute respiratory syndrome (SARS)-CoV, and the new virus named SARS-CoV-2, rarely infect and spread among humans. On January 30, 2020, the International Health Regulations Emergency Committee of the World Health Organisation declared the outbreak of the resulting disease from this new CoV called 'COVID-19', as a 'public health emergency of international concern'. Read More

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http://dx.doi.org/10.1007/s10916-020-01582-xDOI Listing

Gene UCHL1 expresses specifically in mouse uterine decidual cells in response to estrogen.

Histochem Cell Biol 2020 May 25. Epub 2020 May 25.

NHC Key Lab of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, Medical School, Fudan University, Shanghai, 200032, People's Republic of China.

UCHL1 is expressed specifically in the brain and gonads of almost all studied model organisms including Drosophila, zebrafish, amphibians, and mammals, suggesting a high degree of evolutionary conservation in its structure and function. Although UCHL1 has been involved in spermatogenesis in mice, its specific expression in mammal placenta remains elusive. Our previous work has revealed that UCHL1 is highly expressed in oocytes, and has been involved in mouse ovarian follicular development. Read More

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http://dx.doi.org/10.1007/s00418-020-01880-yDOI Listing

Atomic reconstruction in twisted bilayers of transition metal dichalcogenides.

Nat Nanotechnol 2020 May 25. Epub 2020 May 25.

Department of Physics and Astronomy, University of Manchester, Manchester, UK.

Van der Waals heterostructures form a unique class of layered artificial solids in which physical properties can be manipulated through controlled composition, order and relative rotation of adjacent atomic planes. Here we use atomic-resolution transmission electron microscopy to reveal the lattice reconstruction in twisted bilayers of the transition metal dichalcogenides, MoS and WS. For twisted 3R bilayers, a tessellated pattern of mirror-reflected triangular 3R domains emerges, separated by a network of partial dislocations for twist angles θ < 2°. Read More

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http://dx.doi.org/10.1038/s41565-020-0682-9DOI Listing

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells.

Cell Mol Immunol 2020 May 25. Epub 2020 May 25.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore, 117545, Singapore.

T cells react to foreign or self-antigens through T cell receptor (TCR) signaling. Several decades of research have delineated the mechanism of TCR signal transduction and its impact on T cell performance. This knowledge provides the foundation for chimeric antigen receptor T cell (CAR-T cell) technology, by which T cells are redirected in a major histocompatibility complex-unrestricted manner. Read More

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http://dx.doi.org/10.1038/s41423-020-0470-3DOI Listing

Artificial feeder cells expressing ligands for killer cell immunoglobulin-like receptors and CD94/NKG2A for expansion of functional primary natural killer cells with tolerance to self.

Cytotherapy 2020 May 22. Epub 2020 May 22.

Department of Neurosurgery, Section Experimental Neurosurgery/Tumor Immunology, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), Dresden, Germany. Electronic address:

Background Aims: Natural killer (NK) cells are promising cells for immunotherapy of cancer, and there are ongoing efforts to improve their ex vivo expansion to clinically relevant numbers. This study focused on the development of a C1-, C2-, Bw4 killer cell immunoglobulin-like receptor (KIR) ligand and NKG2A ligand-containing feeder cell line for autonomous expansion of functional NK cells.

Methods: PC3-derived feeder cells expressing IL-2, 4-1BBL and membrane-bound IL-15-mutDAP12 (mIL-15d) fusion protein in combinations or alone were generated and used for expansion. Read More

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http://dx.doi.org/10.1016/j.jcyt.2020.02.004DOI Listing

Plant Microbiome Engineering: Expected Benefits for Improved Crop Growth and Resilience.

Trends Biotechnol 2020 May 22. Epub 2020 May 22.

Plant-Microbe Interactions Laboratory, School of Agriculture and Food Sciences, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

Plant-associated microbiomes can boost plant growth or control pathogens. Altering the microbiome by inoculation with a consortium of plant growth-promoting rhizobacteria (PGPR) can enhance plant development and mitigate against pathogens as well as abiotic stresses. Manipulating the plant holobiont by microbiome engineering is an emerging biotechnological strategy to improve crop yields and resilience. Read More

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http://dx.doi.org/10.1016/j.tibtech.2020.04.015DOI Listing

How, When, and Why: High-Density Mapping of Atrial Fibrillation.

Card Electrophysiol Clin 2020 Jun;12(2):155-165

Cardiac Electrophysiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 9 Founders Pavilion, Philadelphia, PA 19104, USA. Electronic address:

High-density (HD) mapping presents opportunities to enhance delineation of atrial fibrillation (AF) substrate, improve efficiency of the mapping procedure without sacrificing safety, and afford new mechanistic insights regarding AF. Innovations in hardware, software algorithms, and development of novel multielectrode catheters have allowed HD mapping to be feasible and reliable. Patients to particularly benefit from this technology are those with paroxysmal AF in setting of preexisting atrial scar, persistent AF, and AF in the setting of complex congenital heart disease. Read More

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http://dx.doi.org/10.1016/j.ccep.2020.02.004DOI Listing

Reframing Telehealth: Regulation, Licensing, and Reimbursement in Connected Care.

Obstet Gynecol Clin North Am 2020 Jun 29;47(2):227-239. Epub 2020 Apr 29.

Department of Obstetrics & Gynecology, Duke University School of Medicine, Box 3967, Durham, NC 27710, USA. Electronic address:

Complexity in regulation and reimbursement of telehealth across the United States yields inconsistent use and availability of services. Drivers of this variation stem from existing regulatory, licensing, and payment policy that was designed for face-to-face care. Emerging technology for connected care continues to outpace the rules that govern its use. Read More

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http://dx.doi.org/10.1016/j.ogc.2020.02.001DOI Listing

Intramuscular injection of human chorionic gonadotropin prior to secretory transformation in patients undergoing frozen-thawed embryo transfer cycles.

Reprod Biol Endocrinol 2020 May 25;18(1):52. Epub 2020 May 25.

Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: The major difference between a natural cycle and an artificially prepared cycle is the lack of luteinizing hormone (LH) peak in the latter. The LH/hCG receptors were identified to express in human endometrium and evidences of experiments also suggested the beneficial role of hCG in embryo implantation, indicating that the LH peak might be of clinical significance and the activation of LH/hCG receptors in the endometrium could improve embryo implantation. Hence, we postulated that the addition of hCG prior to secretory transformation in an artificial cycle might improve pregnancy outcomes. Read More

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http://dx.doi.org/10.1186/s12958-020-00606-yDOI Listing

Enantioselective Hydroxylation of Benzylic C(sp3)-H Bonds by an Artificial Iron Hydroxylase Based on the Biotin-Streptavidin Technology.

J Am Chem Soc 2020 May 26. Epub 2020 May 26.

The selective hydroxylation of C-H bonds is of great interest to the synthetic community. Both homogenous catalysts and enzymes offer complementary means to tackle this challenge. Herein, we show that biotinylated Fe(TAML)-complexes (TAML = Tetra Amido Macrocyclic Ligand) can be used as cofactors for incorporation into streptavidin to assemble artificial hydroxylases. Read More

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http://dx.doi.org/10.1021/jacs.0c02788DOI Listing

[Clinical analysis of chest infections caused by group].

Zhonghua Yi Xue Za Zhi 2020 May;100(20):1578-1581

Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Jining Medical University, Jining 272013, China.

To clarify the clinical characteristics of chest infections caused by group (SAG). A total of 26 patients diagnosed in Affiliated Hospital of Jining Medical University from January 2014 to October 2019 were enrolled. The analyzed clinical data included baseline data, clinical symptoms, imaging manifestations, therapies, and outcomes. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191204-02635DOI Listing

Efficient Transformation of the White Jelly Mushroom Tremella fuciformis (Tremellomycetes) and Its Companion Fungus Annulohypoxylon stygium (Ascomycetes) Mediated by Agrobacterium tumefaciens.

Int J Med Mushrooms 2019 ;21(9):921-930

College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, P.R. China; Key Laboratory of Agro-Microbial Resources and Utilization, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China.

Tremella fuciformis is an edible white jelly mushroom with medicinal qualities. The formation of T. fuciformis fruiting bodies is highly dependent on the presence of Annulohypoxylon stygium under natural conditions and during artificial cultivation. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019031600DOI Listing
January 2019