Search our Database of Scientific Publications and Authors

I’m looking for a

    5604 results match your criteria Artificial Organs[Journal]

    1 OF 113

    Contemporary Oxygenator Design: Shear Stress-Related Oxygen and Carbon Dioxide Transfer.
    Artif Organs 2018 Feb 23. Epub 2018 Feb 23.
    Department of Extra-Corporeal Circulation, Maastricht University Medical Centre, Maastricht, The Netherlands.
    Design of contemporary oxygenators requires better understanding of the influence of hydrodynamic patterns on gas exchange. A decrease in blood path width or an increase in intraoxygenator turbulence for instance, might increase gas transfer efficiency but it will increase shear stress as well. The aim of this clinical study was to examine the association between shear stress and oxygen and carbon dioxide transfer in different contemporary oxygenators during cardiopulmonary bypass (CPB). Read More

    In Vitro Evaluation of ECG-Synchronized Pulsatile Flow Using the i-cor Diagonal Pump in Neonatal and Pediatric ECLS Systems.
    Artif Organs 2018 Feb 23. Epub 2018 Feb 23.
    Department of Pediatrics, Penn State Health Pediatric Cardiovascular Research Center, Penn State College of Medicine, Penn State Health Children's Hospital, Hershey, PA, USA.
    The objective was to assess the i-cor electrocardiogram-synchronized diagonal pump in terms of hemodynamic energy properties for off-label use in neonatal and pediatric extracorporeal life support (ECLS) circuits. The neonatal circuit consisted of an i-cor pump and console, a Medos Hilite 800 LT oxygenator, an 8Fr arterial cannula, a 10Fr venous cannula, 91 cm of 0.6-cm ID arterial tubing, and 91 cm of 0. Read More

    Peritoneal Dialysis Fluid-Induced Fragmentation of Golgi Apparatus as a Biocompatibility Marker.
    Artif Organs 2018 Feb 23. Epub 2018 Feb 23.
    Department of Chemistry for Materials, Faculty of Engineering, Mie University, Mie, Japan.
    In vitro biocompatibility assessments that consider physiologically appropriate conditions of cell exposure to peritoneal dialysis fluids (PDFs) are still awaited. In this study, we found that fragmentation of Golgi apparatus occurred in a pH-dependent manner within 30-min exposure to five distinct commercially available PDFs, which showed no marked difference in their effects on cell viability in the conventional MTT assay. Fluorescence microscopy analysis of labeling antibody against cis-Golgi protein GM130 indicated that the stacked cisternal structure was maintained in the perinuclear area of both M199 culture medium and a neutral-pH PDF groups. Read More

    Bridging to a Long-Term Ventricular Assist Device With Short-Term Mechanical Circulatory Support.
    Artif Organs 2018 Feb 23. Epub 2018 Feb 23.
    Division of Cardiothoracic Transplant and Assist Devices, Baylor College of Medicine, Houston, TX, USA.
    Implanting short-term mechanical circulatory support (MCS) devices as a bridge-to-decision is increasingly popular. However, outcomes have not been well studied in patients who receive short-term MCS before receiving long-term left ventricular assist device (LVAD) support. We analyzed outcomes in our single-center experience with long-term continuous-flow (CF)-LVAD recipients with pre-implantation short-term MCS. Read More

    Titanium Surface Chemical Composition Interferes in the Pseudomonas aeruginosa Biofilm Formation.
    Artif Organs 2018 Feb;42(2):193-199
    Centro Integrado de Inovação Tecnológica do Semiárido, Universidade Federal do Semi-Árido, Mossoró, Brazil.
    Bacterial adhesion on three different surfaces: untreated Ti, plasma nitriding, and plasma carbonitriding Ti substrates were investigated. The samples were placed in bacterial cultures of Pseudomonas aeruginosa to assess biofilm formation. The correlation between the amount of bacteria attached to the surface after a lapse of time with nanotopography and physicochemical properties was performed. Read More

    Changes in Total Cardiac Output and Oxygen Extraction During Exercise in Patients Supported With an HVAD Left Ventricular Assist Device.
    Artif Organs 2018 Feb 12. Epub 2018 Feb 12.
    Schüchtermann-Klinik Bad Rothenfelde, Bad Rothenfelde, Cologne, Germany.
    Following implantation of a left ventricular assist device (LVAD), acceptable functional performance is now being achieved; however, peak VOand peak work load (watts) remain considerably limited. Maximum physical capacity is essentially dependent on generated cardiac output (CO) and arteriovenous oxygen difference (avDO). We investigated the changes in CO and avDOduring exercise in LVAD patients with an HVAD pump (HeartWare Inc. Read More

    Peripheral Artery Disease and Continuous Flow Left Ventricle Assist Device: An Engaging Complement Analysis May Help to Guide Treatment.
    Artif Organs 2018 Feb 13. Epub 2018 Feb 13.
    Cardiology Unit, Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS - ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy.
    Use of continuous flow left ventricle assist device (CF-LVAD) in advanced heart failure (HF) patients results in clinically relevant improvements in survival, functional capacity, and quality of life. Peripheral artery disease (PAD) can occur in patients with CF-LVAD due to the high rate of concomitance between risk factors for atherosclerosis and HF. Diagnosis of PAD can be difficult in the specific setting of a patient supported by this kind of device because of the marked alteration in waveform morphology and velocity created by the artificial physiology of an LVAD. Read More

    Effects of Pulsatile Blood Flow on Oxygenator Performance.
    Artif Organs 2018 Feb 13. Epub 2018 Feb 13.
    Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany.
    Extracorporeal membrane oxygenation (ECMO) is mainly used for the therapy of acute respiratory distress syndrome and chronic obstructive lung disease. In the last years, the development of these systems underwent huge steps in optimization, but there are still problems with thrombus formation, clogging, and thus insufficient gas exchange. One idea of ECMO optimization is a pulsatile blood flow through the oxygenator, but this is still a controversy discussion. Read More

    Type II Minimal-Invasive Extracorporeal Circuit for Aortic Valve Replacement: A Randomized Controlled Trial.
    Artif Organs 2018 Feb 12. Epub 2018 Feb 12.
    Department of Anesthesiology and Pain Therapy, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
    Extracorporeal circulation triggers systemic inflammatory response and coagulation disorders which may lead to unfavorable clinical outcome. A type II minimally-invasive extracorporeal circuit (MiECC) is a closed system with markedly reduced artificial surface as compared to conventional extracorporeal circuits (CECC). The aim of this study was to investigate and compare inflammatory responses, complement activation and selected clinical end-points in isolated surgical aortic valve replacement (SAVR) performed with a type II MiECC circuit or a CECC. Read More

    Evaluation of the Novel Centrifugal Pump, CAPIOX SL, in Chronic Large Animal Experiments.
    Artif Organs 2018 Feb 12. Epub 2018 Feb 12.
    Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
    In the development of a new device for extracorporeal circulation, long-term durability and biocompatibility are required. The CAPIOX SL Pump (SL pump, Terumo Corporation, Tokyo, Japan), which is a centrifugal pump using a two-pivot bearing, was developed with the hope of suppressing pump thrombus formation around the bearings. This study aimed to evaluate the in vivo performance of the SL pump in the condition assumed severe clinical situation for long-term extracorporeal membrane oxygenation (ECMO) support. Read More

    Feasibility and Safety of a Cemented PEEK-on-PE Knee Replacement in a Goat Model: A Preliminary Study.
    Artif Organs 2018 Feb 13. Epub 2018 Feb 13.
    Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
    Polyether-ether-ketone (PEEK) is a potential alternative to metal alloys for use in the orthopedic implants; however, an in vivo study in an appropriate animal model is essential and has not yet been initiated. The aim of the present study was to gather some preliminary evidence regarding the performance and safety of a cemented PEEK-based knee replacement device in a goat model. Fifteen adult goats were randomly divided into two groups; the control group (n = 5), which received a sham operation, and the experimental group (n = 10), which received a total knee arthroplasty with a PEEK-based knee replacement device. Read More

    Implementing and Assessing a Standardized Protocol for Weaning Children Successfully From Extracorporeal Life Support.
    Artif Organs 2018 Feb 8. Epub 2018 Feb 8.
    Department of Congenital Heart Disease and Pediatric Cardiology, University Heart Center Freiburg - Bad Krozingen, Freiburg, Germany.
    Extracorporeal life support (ECLS) weaning is a complex interdisciplinary process with no clear guidelines. To assess ventricular and pulmonary function as well as hemodynamics including end-organ recovery during ECLS weaning, we developed a standardized weaning protocol. We reviewed our experience 2 years later to assess its feasibility and efficacy. Read More

    Hemodynamic Effects of Connection to Continuous Renal Replacement Therapy in a Pediatric Animal Model.
    Artif Organs 2018 Feb 6. Epub 2018 Feb 6.
    Pediatric Intensive Care Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
    To assess the hemodynamic effects of connection to continuous renal replacement therapy (CRRT) in a pediatric experimental animal model. Prospective experimental study was performed using piglets between 2 and 3 months of age and 9-11 kg. CRRT with a Prismaflexmonitor and HF20 filter (surface of 0. Read More

    Heart Transplantation in Patients Supported by ECMO: Is the APACHE IV Score a Predictor of Survival?
    Artif Organs 2018 Feb 2. Epub 2018 Feb 2.
    Cardiothoracic Department, University Hospital of Udine, Udine, Italy.
    Bridge to heart transplantation (HTx) with ECMO is associated with poor outcome, but patient status, according to different levels of multiorgan compromise, is generally not considered. The aim of this study was to analyze the prognostic value of acute physiology, age, and chronic health evaluation IV (APACHE IV) score in this setting. Thirty-two patients underwent HTx bridged with ECMO at our institution between 2005 and 2017; they were divided into two groups, according to a cutoff value of APACHE IV score obtained by Receiver operating characteristic curve analysis for 30-day mortality. Read More

    In Vitro Comparison of Pediatric Oxygenators With and Without Integrated Arterial Filters in Maintaining Optimal Hemodynamic Stability and Managing Gaseous Microemboli.
    Artif Organs 2018 Jan 26. Epub 2018 Jan 26.
    Department of Pediatrics, Penn State Health Pediatric Cardiovascular Research Center, Penn State College of Medicine, Penn State Health Children's Hospital, Hershey, PA, USA.
    The purpose of this study was to compare the Capiox FX15 oxygenator with integrated arterial filter to the Capiox RX15 oxygenator with separate Capiox AF125 arterial filter in terms of hemodynamic properties and gaseous microemboli (GME) capturing. Trials were conducted at varying flow rates (2.0 L/min, 3. Read More

    Hybrid Continuous-Flow Total Artificial Heart.
    Artif Organs 2018 Jan 18. Epub 2018 Jan 18.
    The BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.
    Clinical studies using total artificial hearts (TAHs) have demonstrated that pediatric and adult patients derive quality-of-life benefits from this form of therapy. Two clinically-approved TAHs and other pumps under development, however, have design challenges and limitations, including thromboembolic events, neurologic impairment, infection risk due to large size and percutaneous drivelines, and lack of ambulation, to name a few. To address these limitations, we are developing a hybrid-design, continuous-flow, implantable or extracorporeal, magnetically-levitated TAH for pediatric and adult patients with heart failure. Read More

    Refractory Pulmonary Edema and Upper Body Hypoxemia During Veno-Arterial Extracorporeal Membrane Oxygenation-A Case for Atrial Septostomy.
    Artif Organs 2018 Jan 18. Epub 2018 Jan 18.
    Department of Critical Care Medicine, Mayo Clinic, Phoenix, AZ, USA.
    Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides mechanical circulatory support for patients with advanced cardiogenic shock, facilitating myocardial recovery and limiting multi-organ failure. In patients with severely limited left ventricular ejection, peripheral VA-ECMO can further increase left ventricular and left atrial pressures (LAP). Failure to decompress the left heart under these circumstances can result in pulmonary edema and upper body hypoxemia, that is, myocardial and cerebral ischemia. Read More

    A Weaning Protocol for Venovenous Extracorporeal Membrane Oxygenation With a Review of the Literature.
    Artif Organs 2018 Jan 18. Epub 2018 Jan 18.
    Dewitt Daughtry Family Department of Surgery, Division of Cardiothoracic Surgery, University of Miami, Leonard M Miller School of Medicine, Miami, FL, USA.
    Several articles have discussed the weaning process for venoarterial extracorporeal membrane oxygenation; however, there is no published report to outline a standardized approach for weaning a patient from venovenous extracorporeal membrane oxygenation (ECMO). This complex process requires an organized approach and a thorough understanding of ventilator management and ECMO physiology. The purpose of this article is to describe the venovenous ECMO weaning protocol used at our institution as well as provide a review of the literature. Read More

    Investigation of the Axial Gap Clearance in a Hydrodynamic-Passive Magnetically Levitated Rotary Blood Pump Using X-Ray Radiography.
    Artif Organs 2018 Jan 17. Epub 2018 Jan 17.
    pd|z Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
    The HeartWare HVAD is a radial rotary blood pump with a combination of passive magnetic and hydrodynamic bearings to levitate the impeller. The axial gap size between impeller and housing in this bearing and its sensitivity to speed, flow, and pressure difference is difficult to assess. Shear stresses are exceptionally high in this tiny gap making it important for blood damage and related adverse events. Read More

    The Influence of Colloid Osmotic Pressure on Hydrostatic Pressures in High- and Low-Flux Hemodialyzers.
    Artif Organs 2018 Jan 17. Epub 2018 Jan 17.
    Institute of Physiology, Medical University of Graz, Graz, Austria.
    The aim of this study was to examine the relationship between hydrostatic trans-membrane pressure (TMP) and colloid osmotic pressure (COP) in low-flux (LF) and high-flux (HF) dialyzers. Hydrostatic pressures were measured in dialyzers distinguished by their ultrafiltration coefficient K(16 and 85 mL/h/mm Hg) under constant dialysate flow and variable blood flow (Q) ranging from 0 to 400 mL/min using (i) alginate (70 kDa) dissolved in dialysate, (ii) diluted, undiluted, and concentrated plasma, or (iii) whole blood at different hematocrit, all in absence of ultrafiltration (UF). For a given fluid, TMPlinearly increased with increasing Q. Read More

    Extracorporeal Membrane Oxygenation for Refractory Severe Respiratory Failure in Acute Interstitial Pneumonia.
    Artif Organs 2018 Jan 11. Epub 2018 Jan 11.
    Department of Emergency and Intensive Care Medicine, Centro Hospitalar S. João, Porto, Portugal.
    Acute interstitial pneumonia (AIP) is a rare idiopathic interstitial lung disease with rapid progressive respiratory failure and high mortality. In the present report, three cases of AIP complicated by refractory respiratory failure supported with extracorporeal membrane oxygenation (ECMO) are presented. One male and two female patients (ages 27-59) were included. Read More

    In Vitro Comparison of Two Neonatal ECMO Circuits Using a Roller or Centrifugal Pump With Three Different In-Line Hemoconcentrators for Maintaining Hemodynamic Energy Delivery to the Patient.
    Artif Organs 2018 Jan 11. Epub 2018 Jan 11.
    Department of Pediatrics, Penn State Health Pediatric Cardiovascular Research Center, Penn State College of Medicine, Penn State Health Children's Hospital, Hershey, PA, USA.
    The objective of this study was to compare three different hemoconcentrators (Hemocor HPH 400, Mini, and Junior) with two different neonatal ECMO circuits using a roller or a centrifugal pump at different pseudo-patient pressures and flow rates in terms of hemodynamic properties. This evidence-based research is necessary to optimize the ECMO circuitry for neonates. The circuits used a 300-mL soft-shell reservoir as a pseudo-patient approximating the blood volume of a 3 kg neonate, two blood pumps, and a Quadrox-iD Pediatric oxygenator with three different in-line hemoconcentrators (Hemocor HPH 400, Mini, and Junior). Read More

    Managing Traps and Pitfalls During Initial Steps of an ECMO Retrieval Program Using a Miniaturized Portable System: What Have We Learned From the First Two Years?
    Artif Organs 2017 Dec 27. Epub 2017 Dec 27.
    Department of Cardiothoracic Surgery, University Hospital Cologne, Cologne, Germany.
    The aim of this study was to provide early and mid-term results of the newly established extracorporeal membrane oxygenation (ECMO) retrieval service in a tertiary cardiothoracic center using the miniaturized portable Cardiohelp System (Maquet, Rastatt, Germany). A particular attention was paid to organizational and logistic specifics as well as challenges and pitfalls associated with initial phase of the program. From January 2015 until January 2017 a heterogenic group of 28 consecutive patients underwent ECMO implantation in distant hospitals for acute cardiac, pulmonary or combined failure as a bridge-to-decision and were subsequently transported to our institution. Read More

    Modification of Aortic Cannula With an Inlet Chamber to Induce Spiral Flow and Improve Outlet Flow.
    Artif Organs 2017 Dec 27. Epub 2017 Dec 27.
    Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Malaysia.
    Physiologically, blood ejected from the left ventricle in systole exhibited spiral flow characteristics. This spiral flow has been proven to have several advantages such as lateral reduction of directed forces and thrombus formation, while it also appears to be clinically beneficial in suppressing neurological complications. In order to deliver spiral flow characteristics during cardiopulmonary bypass operation, several modifications have been made on an aortic cannula either at the internal or at the outflow tip; these modifications have proven to yield better hemodynamic performances compared to standard cannula. Read More

    Native Bovine and Porcine Pericardia Respond to Load With Additive Recruitment of Collagen Fibers.
    Artif Organs 2017 Dec 27. Epub 2017 Dec 27.
    Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
    Bovine and porcine pericardia are currently used for manufacturing prosthetic heart valves: their design has become an increasingly important area of investigation in parallel with progressively expanding indications for the transcutaneous approach to heart valves replacement. Before being cut and shaped, pericardial tissues are expected to be properly characterized. Actually, the mechanical assessment of these biomaterials lacks standardized protocols. Read More

    Recognition of a Virtual Maze Scene Using Simulated Prosthetic Vision.
    Artif Organs 2017 Dec 21. Epub 2017 Dec 21.
    School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, China.
    A real-time psychological physics experimental platform was built to aid in discovering the best real-time image processing strategy for the limited number of electrodes, and in providing the most useful prosthetic implant visual information. A number of maze pathfinder tasks were performed at low resolution to simulate use by blind individuals in performing daily visual activities. In this study, simple (5 rows × 5 columns), medium (8 × 8), and complex (11 × 11) maze models were created in 3DMAX. Read More

    Neutrophil Gelatinase-Associated Lipocalin as a Biomarker of Allograft Function After Renal Transplantation: Evaluation of the Current Status and Future Insights.
    Artif Organs 2018 Jan 20;42(1):8-14. Epub 2017 Dec 20.
    Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, St. Orsola Hospital, University of Bologna, Bologna, Italy.
    Neutrophil gelatinase-associated lipocalin (NGAL), a protein belonging to the lipocalin superfamily initially found in activated neutrophils, is expressed by several cell types, including kidney tubule. The increase in NGAL production and release from tubular cells in response to various insults has been proven to predict acute kidney injury (AKI). For this reason, it has emerged as a valuable noninvasive biomarker of AKI in clinical nephrology. Read More

    Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
    Artif Organs 2017 Dec 20. Epub 2017 Dec 20.
    Hubei Key Laboratory of Medical Technology on Transplantation, Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China, Hubei.
    The protective role of hypoxia-inducible factor-1 (HIF-1) against liver ischemia-reperfusion injury has been well proved. However its role in liver donation and preservation from donation after cardiac death (DCD) is still unknown. The objective of this study was to test the hypothesis that pharmaceutical stabilization of HIF-1 in DCD donors would result in a better graft liver condition. Read More

    A Decrease in Hypoxic Pulmonary Vasoconstriction Correlates With Increased Inflammation During Extended Normothermic Ex Vivo Lung Perfusion.
    Artif Organs 2017 Dec 20. Epub 2017 Dec 20.
    Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
    Normothermic ex vivo lung perfusion (EVLP) is an evolving technology to evaluate function of donor lungs to determine suitability for transplantation. We hypothesize that hypoxic pulmonary vasoconstriction (HPV) during EVLP will provide a more sensitive parameter of lung function to determine donor lung quality for lung transplantation. Eight porcine lungs were procured, and subsequently underwent EVLP with autologous blood and STEEN solution for 10 h. Read More

    Development of Tissue-Engineered Ligaments: Elastin Promotes Regeneration of the Rabbit Medial Collateral Ligament.
    Artif Organs 2017 Dec 21. Epub 2017 Dec 21.
    Department of Chemistry for Materials, Mie University, Graduate School of Engineering, Tsu, Mie, Japan.
    When ligaments are injured, reconstructive surgery is sometimes required to restore function. Methods of reconstructive surgery include transplantation of an artificial ligament and autotransplantation of a tendon. However, these methods have limitations related to the strength of the bone-ligament insertion and biocompatibility of the transplanted tissue after surgery. Read More

    Melt Electrospun Bilayered Scaffolds for Tissue Integration of a Suture-Less Inflow Cannula for Rotary Blood Pumps.
    Artif Organs 2017 Dec 13. Epub 2017 Dec 13.
    Innovative Cardiovascular Engineering and Technology Laboratory (ICETLAB), Critical Care Research Group, The Prince Charles Hospital, Chermside, Queensland, Australia.
    Implantation of left ventricular assist devices typically requires cardiopulmonary bypass support, which is associated with postoperative complications. A novel suture-less inflow cannula, which can be implanted without bypass, uses mild myocardial compression to seal the interface, however, this may lead to necrosis of the myocardium. To circumvent this issue, a bilayered scaffold has been developed to promote tissue growth at the interface between cannula and myocardium. Read More

    1 OF 113