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Artif Organs 2021 Apr 28. Epub 2021 Apr 28.

Baxter Deutschland GmbH, Unterschleissheim, Germany.

Patients with acute respiratory distress syndrome and acute kidney injury (AKI) treated by kidney replacement therapy may also require treatment with extracorporeal carbon dioxide removal (ECCO R) devices to permit protective or ultraprotective mechanical ventilation. We developed a mathematical model of acid-base balance during extracorporeal therapy using ECCO R and continuous venovenous hemofiltration (CVVH) devices applied in series for treatment of mechanically ventilated AKI patients. Published data from clinical studies of mechanically ventilated AKI patients treated by CVVH at known infusion rates of substitution fluid without ECCO R were used to adjust model parameters to fit plasma levels of arterial partial pressure of carbon dioxide (PaCO ), arterial plasma bicarbonate concentration ([HCO ]), and plasma pH (as well as certain other unmeasured physiological variables). Read More

Artif Organs 2021 Apr 28. Epub 2021 Apr 28.

Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.

Despite the increasing incidence in heart failure, advancements in mechanical circulatory support have become minimal. A new type of mechanical circulatory support, direct cardiac compression, is a novel support paradigm that involves a soft deformable cup around the ventricles, compressing it during systole. No group has yet investigated the biomechanical consequences of such an approach. Read More

Artif Organs 2021 Apr 28. Epub 2021 Apr 28.

Chemical Engineering Faculty, Sahand University of Technology, Tabriz, 51335-1996, Iran.

Due to the electrical conductivity, pyrrole-based scaffolds are one of the attractive biomaterials in the regeneration of electrically active tissues like the heart and brain. Here, we investigated the impact of polyurethane/pyrrole scaffold on the angiogenesis differentiation of rabbit mesenchymal stem cells toward endothelial lineage in vitro. Nanoelectrospun polyurethane/pyrrole fibers were synthesized and characterized using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectrum analysis, scanning electron microscope (SEM) imaging. Read More

Artif Organs 2021 Apr 28. Epub 2021 Apr 28.

Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.

The monitoring of relative blood volume (RBV) changes during hemodialysis is increasingly used to evaluate the effect of dialyzer ultrafiltration on intravascular volume to guide the removal of excess fluid in a manner that maintains hemodynamic stability of the patient. RBV monitoring is typically based on an optical or acoustic sensor placed in the arterial blood line that measures a marker of hemoconcentration, such as hematocrit, hemoglobin, or total blood protein. However, the accuracy of RBV monitors and the impact of their clinical use remain the subject of ongoing debate. Read More

Artif Organs 2021 Apr 28. Epub 2021 Apr 28.

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases, Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan Hubei, 430071, PR China.

Background: In this study, we evaluated the restoring and defatting effect of hypothermic oxygenated perfusion (HOPE) on severe steatotic liver grafts with a defatting cocktail (DF) in a rat model.

Methods: Severe (≥60%) hepatic macrosteatosis was induced by a high-fat diet (HFD) for six weeks, after which the rats were randomly divided into four following groups: Control group, with lean livers being preserved in static cold storage (SCS) at 0-4℃ for 45 min; SCS group, with a steatotic liver graft (SLG) being preserved in SCS at 0-4℃ for 4 hours; HOPE group, where SLG was perfused with 3-h HOPE followed by 1-h SCS; HOPE+DF group, HOPE with the addition of DF. Graft function after orthotopic liver transplantation was assessed in terms of mitochondrial function (ATP, Glycogen), endoplasmic reticulum stress (PPY, GRP78, CHOP, and ATF-6), cell apoptosis (Tunel assay, Caspase-3), inflammatory level (HMGB1, TLR4, IL-1β, IL-6. Read More

Artif Organs 2021 Apr 27. Epub 2021 Apr 27.

KfH Kidney Center Berlin-Köpenick, Berlin, Germany.

Online hemodiafiltration machines equipped with a blood volume monitor and the possibility to rapidly infuse exact amounts of ultra-pure dialysate into the extracorporeal circulation can be used to determine absolute blood volume in clinical practice. The aim of the present study was to evaluate the reproducibility of such measurements. Intra-individual reproducibility was evaluated in four measurements taken in hourly intervals within the same dialysis treatment. Read More

Artif Organs 2021 Apr 27. Epub 2021 Apr 27.

Department of Biochemistry, Hospital Clínic Barcelona, Barcelona, Spain.

Toray has created a new generation of dialyzers, the polysulphone (TS) UL series, and polymethylmethacrylate (PMMA) NF-U series, which offer enhanced efficacy over the previous TS-S series and NF-H series. The aim of this study was to evaluate the safety and efficacy of these dialyzer series versus contrasted expanded hemodialysis (HDx) and postdilution hemodiafiltration (HDF). We conducted a prospective study in 12 patients. Read More

Artif Organs 2021 Apr 28. Epub 2021 Apr 28.

Second Department of Surgery, Kochi Medical School, Nankoku-city, 783-8505, Japan.

Although de-airing procedures are commonly performed during cardiac surgery, use of these procedures is not necessarily based on evidence. Uncertainly remains around the size of bubbles that can be detected by echocardiography, whether embolized air or carbon dioxide can be absorbed, and the reasons for embolic events occurring despite extensive de-airing. Since air bubbles are invisible in the blood, we used simple experimental models employing water and 10% dextran solution to determine the correlation between actual bubble size and the depicted size on echocardiography, bubble size and floatation velocity, and the absorption of carbon dioxide under embolization and irrigation conditions. Read More

Artif Organs 2021 Apr 19. Epub 2021 Apr 19.

Department of Cardiac-, Thoracic-, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

An intra-cavitary left ventricular (LV) thrombus is a relative contraindication to LV assist device (LVAD) implantation based on increased thromboembolic risks. Herein, we present our experience with LVAD patients with or without preoperative diagnosis of LV-thrombus. We retrospectively investigated 563 patients who received LVAD implantation between 2004 and 2018. Read More

Artif Organs 2021 May;45(5):443-444

Artif Organs 2021 May;45(5):441-442

Division of Cardiac Surgery, Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

Artif Organs 2021 May;45(5):528-530

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.

Artif Organs 2021 May;45(5):445-446

Aeson, the Carmat Total Artificial Heart has been recently approved by the FDA for beginning enrollment in the United States. This follows their recent attainment of CE marking in 2020. Read More

Artif Organs 2021 Apr 13. Epub 2021 Apr 13.

ReCO2very Therapies GmbH, Bad Klosterlausnitz, Germany.

As a leading cause of death worldwide, heart failure is a serious medical condition in which many critically ill patients require temporary mechanical circulatory support (MCS) as a bridge-to-recovery or bridge-to-decision. In many cases, the TandemHeart® system is used to unload the left heart by draining blood from the left atrium (LA) to the femoral artery via a transseptal multistage cannula. However, even though correct positioning of the cannula is crucial for a safe treatment, the long cannula tip currently used in transseptal cannulas complicates positioning, making the cannula moreover vulnerable to displacement during MCS. Read More

Artif Organs 2021 Apr 5. Epub 2021 Apr 5.

Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University, Japan.

Hyperglycemia associated with insulin resistance is common in surgical patients with and without diabetes and is associated with poor surgical outcomes. Several studies have recently shown that a closed-loop blood glucose monitoring system in the form of an artificial pancreas is safe and effective for surgical patients. In this study, we analyzed the risk factors for insulin resistance in patients using an artificial pancreas. Read More

Artif Organs 2021 Apr 2. Epub 2021 Apr 2.

Department of Cardiac-, Thoracic-, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

Artif Organs 2021 Apr;45(4):336-337

Artif Organs 2021 Mar 17. Epub 2021 Mar 17.

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, P.R. China.

To prepare a tissue-engineered pulmonary valved conduit (PVC) with good tensile strength and biocompatibility. Sixty adult porcine PVCs were used to determine the optimal decellularization time. Five juvenile porcine decellularized PVCs and five juvenile porcine crosslinked PVCs were subsequently prepared according to the optimized decellularization and crosslinking methods. Read More

Artif Organs 2021 Mar 16. Epub 2021 Mar 16.

Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Prognosis of patients suffering from acute respiratory distress syndrome (ARDS) is poor. This is especially true for immunosuppressed patients. It is controverisal whether these patients should receive veno-venous extracorporeal membrane oxygenation (VV ECMO) while evidence on this topic is sparse. Read More

Artif Organs 2021 Apr 11;45(4):330-331. Epub 2021 Mar 11.

Division of Cardiac Surgery, Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

Artif Organs 2021 Mar 9. Epub 2021 Mar 9.

Department of Anesthesia and Intensive Care, IRCCS ISMETT, UPMC Italy, Palermo, Italy.

CytoSorb is a promising tool to treat severe inflammatory status with multiple mechanisms in the acute care setting. Its effect on drugs is, however, poorly documented in vivo, although removal of small molecules might translate into decreased blood levels of life-saving medications. The aim of this study was to assess the impact of CytoSorb on vancomycin and bivalirudin clearance in a large population of critically ill patients. Read More

Artif Organs 2021 Mar 9. Epub 2021 Mar 9.

Cardiovascular, Medical and research Center, perfusion, Tehran, Iran.

Background: Zero-balance ultrafiltration (Z-BUF) is considered a significant method during cardiopulmonary bypass (CPB), and has always received support regarding its key role in monitoring electrolyte abnormalities including potassium and sodium derangements and managing them which occur commonly during CPB. With Z-BUF procedure's impact on controlling electrolyte abnormalities, we conducted a study in order to find out the most efficient solution regarding managing potassium and sodium levels to be selected as replacement fluid in Z-BUF out of the three commonly used normal saline, ringer's and ringer's lactate.

Method: a randomized clinical trial study was conducted and 90 patients were divided into three groups. Read More

Artif Organs 2021 Mar 9. Epub 2021 Mar 9.

Department of Cardiac Surgery, Tours University Hospital, Tours, France.

Preservation of right ventricle vascularization that is dependent on left coronary network collateral development is essential during left ventricular assist device implantation to avoid postoperative right heart failure. Our technique was performed on a patient who underwent implantation as a bridge to transplantation; the technique is characterized by providing a moderate lateral and inferior displacement of the inflow cannula position, which achieves both the objectives of respecting the apical course of a left anterior descending coronary artery supplying an occluded right coronary and of maintaining a sufficient orientation degree toward the plane of the mitral valve for correct left ventricular unloading. Read More

Artif Organs 2021 Mar 8. Epub 2021 Mar 8.

Department of Surgical Research, Clinic for General, Visceral and Transplantation Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Organ shortage and the increasing use of extended criteria donor grafts for transplantation drives efforts for more efficient organ preservation strategies from simple cold storage toward dynamic organ reconditioning. The choice of a suitable preservation solution is of high relevance in different organ preservation or reconditioning situations. Custodiol-MP is a new machine perfusion solution giving the opportunity to add colloids according to organ requirements. Read More

Artif Organs 2021 Mar 8. Epub 2021 Mar 8.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.

As pump thrombosis is reduced in current-generation ventricular assist devices (VAD), adverse events such as bleeding or stroke remain at unacceptable rates. Thrombosis around the VAD inlet cannula (IC) has been highlighted as a possible source of stroke events. Recent computational fluid dynamics (CFD) studies have attempted to characterize the thrombosis risk of different IC-ventricle configurations. Read More

Artif Organs 2021 Mar 3. Epub 2021 Mar 3.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

Artif Organs 2021 Mar 3. Epub 2021 Mar 3.

Trauma and Acute Critical Care Center, Tokyo Medical and Dental University, Tokyo, Japan.

Veno-venous extracorporeal membrane oxygenation (VV ECMO) is an effective and proven adjunct support for various severe respiratory failures requiring invasive mechanical ventilation and cardiovascular support. In response to the rapidly increasing number of COVID-19 patients in Japan, we launched an ECMO support team comprised of multidisciplinary experts including physicians, nurses, perfusionists, and bioethicists in preparation for the threat of a pandemic. From April 2 to July 15, 2020, Tokyo Medical and Dental University hospital treated 104 PCR confirmed COVID-19 patients. Read More

Artif Organs 2021 Mar;45(3):E38

Artif Organs 2021 Mar;45(3):203-204

Division of Cardiac Surgery, Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

Artif Organs 2021 Mar;45(3):201-202

Division of Cardiac Surgery, Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.