322,818 results match your criteria Artificial Intelligence in Medicine [Journal]


Sublethal and Hormesis Effects of Clothianidin on the Black Cutworm (Lepidoptera: Noctuidae).

J Econ Entomol 2018 Dec;111(6):2809-2816

College of Plant Protection, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong, P.R. China.

The black cutworm, Agrotis ipsilon (Hufnagel) (Lepidoptera: Noctuidae), has been considered a major insect pest in China that causes damage to corn at the seeding stage. The present study measured the lethal and sublethal effects of the neonicotinoid insecticide clothianidin on A. ipsilon. Read More

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December 2018

Computational conformational analysis of α-thrombin inhibitors possessing distinct scaffolds in aqueous solution and on Ala-sheet.

Authors:
Keigo Gohda

J Mol Graph Model 2018 Dec 3;87:165-171. Epub 2018 Dec 3.

Computer-aided Molecular Modeling Research Center, Kansai (CAMM-Kansai), 3-32-302, Tsuto-Otsuka, Nishinomiya, 663-8241, Japan. Electronic address:

Recent computational simulations on protein-ligand binding/unbinding have precisely been uncovering the ligand-binding process at the atomic level. In the process, the non-specific binding of ligands to the target site is suggested to occur before binding to the target. We in this study analyzed the conformations of ligands under the non-specific binding on a protein surface to figure out the differences in the conformational characteristics in aqueous solution using the 55-ns molecular dynamic simulation. Read More

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December 2018

Impact of selenium nano-particles in semen extender on bull sperm quality after cryopreservation.

Theriogenology 2018 Dec 5;126:121-127. Epub 2018 Dec 5.

Animal Production Research Institute, Dokki, Giza, Egypt.

The aim of this study was to evaluate the effect of adding different concentrations of selenium nano-particles (Se-NPs) in semen extender on bull sperm cryopreservation. Five healthy, fertile Friesian bulls were used, and the ejaculates were obtained using an artificial vagina. Semen of all bulls were pooled and diluted in a tris-yolk fructose (TYF) extender supplemented with Se-NPs at concentrations of 0 (T1, control), 0. Read More

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December 2018

Lecithin doped electrospun poly(lactic acid)-thermoplastic polyurethane fibers for hepatocyte viability improvement.

Colloids Surf B Biointerfaces 2018 Sep 28;175:264-271. Epub 2018 Sep 28.

College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

The development of hepatocyte cultures in vitro holds great significance in the study of bioartificial liver support systems. Electrospun fiber cultures have received widespread attention as an effective method to culture hepatocytes in vitro. Polylactic acid (PLA) -a synthetic polymer with high biocompatibility and biodegradability- is widely used to fabricate electrospun fibers in the biomedical field. Read More

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September 2018

Self-Assembled GFFYK Peptide Hydrogel Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in a Mouse Hindlimb Ischemia Model.

Acta Biomater 2018 Dec 11. Epub 2018 Dec 11.

Nankai University School of Medicine, Tianjin 300071, China; The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, The College of Life Science, Tianjin 300071, China. Electronic address:

Mesenchymal stem cell (MSC) transplantation has emerged as a very promising strategy for the treatments of peripheral artery disease (PAD). However, MSC-based therapies are limited by low cell retention and survival rate in the ischemic zone. Small molecular (SM) hydrogels have shown attractive abilities to enhance the therapeutic effects of human MSCs via promoting their proliferation or maintaining their differentiation potential. Read More

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December 2018
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Predicting drug-target interactions using Lasso with random forest based on evolutionary information and chemical structure.

Genomics 2018 Dec 11. Epub 2018 Dec 11.

College of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266061, China; Artificial Intelligence and Biomedical Big Data Research Center, Qingdao University of Science and Technology, Qingdao 266061, China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. Electronic address:

The identification of drug-target interactions has great significance for pharmaceutical scientific research. Since traditional experimental methods identifying drug-target interactions is costly and time-consuming, the use of machine learning methods to predict potential drug-target interactions has attracted widespread attention. This paper presents a novel drug-target interactions prediction method called LRF-DTIs. Read More

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December 2018

Organoid Modeling of the Tumor Immune Microenvironment.

Cell 2018 Dec;175(7):1972-1988.e16

Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes (TILs) as a cohesive unit has been particularly elusive. Here, an air-liquid interface (ALI) method propagated patient-derived organoids (PDOs) from >100 human biopsies or mouse tumors in syngeneic immunocompetent hosts as tumor epithelia with native embedded immune cells (T, B, NK, macrophages). Read More

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December 2018
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Nocturnal ventricular repolarization lability predicts cardiovascular mortality in the Sleep Heart Health Study.

Am J Physiol Heart Circ Physiol 2018 Dec 14. Epub 2018 Dec 14.

Institut für Biomedizinische Technik, TU Dresden.

Background-The objective of this study was to quantify repolarization lability and its association with sex, sleep stage and cardiovascular mortality. Methods-We analyzed polysomnographic recordings of 2,263 participants enrolled in the Sleep heart health study (SHHS-2). Beat-to-beat QT interval variability (QTV) was quantified for consecutive epochs of 5 minutes according to the dominant sleep stage (AWAKE, NREM2, NREM3, REM). Read More

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December 2018

The relationship between second language acquisition and nonverbal cognitive abilities.

J Exp Psychol Gen 2018 Dec 13. Epub 2018 Dec 13.

Department of Experimental Psychology.

We monitored the progress of 40 children when they first started to acquire a second language (L2) implicitly through immersion. Employing a longitudinal design, we tested them before they had any notions of an L2 (Time 0) and after 1 school year of L2 exposure (Time 1) to determine whether cognitive abilities can predict the success of L2 learning. Task administration included measures of intelligence, cognitive control, and language skills. Read More

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December 2018

A Novel Approach to Study the Effect of Ciprofloxacin on Biofilms of spp. Using Confocal Laser Scanning Microscopy.

Pol J Microbiol 2018 ;67(4):431-440

Department of Medical Microbiology, Medical University , Lublin , Poland.

Non-diphtherial corynebacteria are Gram-positive rods that cause opportunistic infections, what is supported by their ability to produce biofilm on artificial surfaces. In this study, the characteristic of the biofilm produced on vascular and urological catheters was determined using a confocal microscopy for the most frequently involved in infections diphtheroid species. They were represented by the reference strains of Corynebacterium striatum ATCC 6940 and C. Read More

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January 2018

[Evaluating auditory pathway by promontory stimulation test and postoperative hearing rehabilitation(28 cases)].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1851-1856

Department of Otolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences,Beijing, 100730, China.

Objective:〖WT〗To evaluate auditory pathway in patients by promontory stimulation test(PST) before artificial cochlear implantation(CI), and to analyze the relationship between postoperative hearing rehabilitation and PST. Selecting 28 cases of adult subjects without residual hearing who accepted promontory stimulation test, different etiology led to bilateral severe sensor neural deafness. PST was examined by measuring the electric auditory threshold(T value) and maximum comfort threshold(M value) of 50, 100 and 200 Hz pulse square waves, and by measuring frequency discrimination. Read More

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December 2018

[Artificial intelligence for future MD].

G Ital Nefrol 2018 Dec;35(6)

Psicologa Clinica, Psicoterapeuta Sistemico Relazionale IIPR, Psicologa Clinica Ismett, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione - IRCCS, Palermo.

Health care workers need artificial intelligence. Artificial intelligence is a set of studies and techniques that tend to the realization of machines, which solve complex problems automatically, simulating or emulating human intelligence activities. Human intelligence is innate, creative, emotional, sporting, social in the collective and connected future. Read More

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December 2018

Repair of tricuspid papillary muscle rupture after percutaneous coronary intervention.

Authors:
Shinji Kanemitsu

Multimed Man Cardiothorac Surg 2018 Dec 6;2018. Epub 2018 Dec 6.

Department of Thoracic and Cardiovascular Surgery Mie University Graduate School of Medicine 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

Papillary muscle rupture is a rare complication after myocardial infarction and almost all cases occur in the mitral valve papillary muscle. Tricuspid regurgitation development after right ventricular myocardial infarction caused by papillary muscle rupture is extremely rare.  In this video tutorial we present a 70-year-old man with massive tricuspid regurgitation caused by papillary muscle rupture after percutaneous stenting of the right coronary artery. Read More

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December 2018

Poly(β-Amino Esters): Synthesis, Formulations, and Their Biomedical Applications.

Adv Healthc Mater 2018 Dec 14:e1801359. Epub 2018 Dec 14.

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Poly(β-amino ester) (abbreviated as PBAE or PAE) refers to a polymer synthesized from an acrylate and an amine by Michael addition and has properties inherent to tertiary amines and esters, such as pH responsiveness and biodegradability. The versatility of building blocks provides a library of polymers with miscellaneous physicochemical and mechanical properties. When used alone or together with other materials, PBAEs can be fabricated into different formulations in order to fulfill various requirements in drug delivery (for instance, gene, anticancer drugs, and antimicrobials delivery) and natural complex mimicry (nanochaperones). Read More

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December 2018
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Artificial intelligence and upper gastrointestinal endoscopy: current status and future perspective.

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Graduate School of Informatics, Nagoya University, Nagoya, Japan.

With recent breakthroughs in artificial intelligence, computer-aided diagnosis (CAD) for upper gastrointestinal endoscopy is gaining increasing attention. Main research focuses in this field include automated identification of dysplasia in Barrett's esophagus and detection of early gastric cancers. By helping endoscopists avoid missing and mischaracterizing neoplastic change in both the esophagus and stomach, these technologies potentially contribute to solving current limitations of gastroscopy. Read More

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December 2018

Pharmacological induction of a progenitor state for the efficient expansion of primary human hepatocytes.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.

The liver is an organ with strong regenerative capacity, yet primary hepatocytes have a low amplification potential in vitro, a major limitation for the cell-based therapy of liver disorders and for ex vivo biological screens. Induced pluripotent stem cells (iPSC) may help to circumvent this obstacle, but often harbor genetic and epigenetic abnormalities limiting their potential. Here, we describe the pharmacological induction of proliferative human hepatic progenitor cells (HPC) through a cocktail of growth factors and small molecules mimicking the signaling events involved in liver regeneration. Read More

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December 2018

Cell-Templated Silica Microparticles with Supported Lipid Bilayers as Artificial Antigen-Presenting Cells for T Cell Activation.

Adv Healthc Mater 2018 Dec 13:e1801188. Epub 2018 Dec 13.

Department of Bioengineering and, Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, 98195, USA.

Biomaterial properties that modulate T cell activation, growth, and differentiation are of significant interest in the field of cellular immunotherapy manufacturing. In this work, a new platform technology that allows for the modulation of various activation particle design parameters important for polyclonal T cell activation is presented. Artificial antigen presenting cells (aAPCs) are successfully created using supported lipid bilayers on various cell-templated silica microparticles with defined membrane fluidity and stimulating antibody density. Read More

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December 2018

Inferring sleep stage from local field potentials recorded in the subthalamic nucleus of Parkinson's patients.

J Sleep Res 2018 Dec 13:e12806. Epub 2018 Dec 13.

Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado.

Parkinson's disease (PD) is highly comorbid with sleep dysfunction. In contrast to motor symptoms, few therapeutic interventions exist to address sleep symptoms in PD. Subthalamic nucleus (STN) deep brain stimulation (DBS) treats advanced PD motor symptoms and may improve sleep architecture. Read More

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December 2018

A Highly Active Star Decahedron Cu Nanocatalyst for Hydrocarbon Production at Low Overpotentials.

Adv Mater 2018 Dec 14:e1805405. Epub 2018 Dec 14.

Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

The electrochemical carbon dioxide reduction reaction (CO RR) presents a viable approach to recycle CO gas into low carbon fuels. Thus, the development of highly active catalysts at low overpotential is desired for this reaction. Herein, a high-yield synthesis of unique star decahedron Cu nanoparticles (SD-Cu NPs) electrocatalysts, displaying twin boundaries (TBs) and multiple stacking faults, which lead to low overpotentials for methane (CH ) and high efficiency for ethylene (C H ) production, is reported. Read More

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December 2018
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Metallosupramolecular Photonic Elastomers with Self-Healing Capability and Angle-Independent Color.

Adv Mater 2018 Dec 13:e1805496. Epub 2018 Dec 13.

Key Lab of Materials Chemistry for Energy Conversion and Storage of Ministry of Education (HUST), School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China.

Photonic elastomers that can change colors like a chameleon have shown great promise in various applications. However, it still remains a challenge to produce artificial photonic elastomers with desired optical and mechanical properties. Here, the generation of metallosupramolecular polymer-based photonic elastomers with tunable mechanical strength, angle-independent structural color, and self-healing capability is reported. Read More

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December 2018
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Evaluation of artificial heating sources for the thermoregulation of Aldabra giant tortoises (Aldabrachelys gigantea) in Zurich zoo.

Zoo Biol 2018 Nov 22;37(6):458-465. Epub 2018 Nov 22.

Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty, University of Zürich, Zurich, Switzerland.

We recorded the thermoregulatory patterns of five Aldabra giant tortoises (Aldabrachelys gigantea) (25-193 kg) during spring (ZRH spring trial), after the installation of a heating area (concrete heat pad and basking lamp) at Zurich Zoo, Switzerland. The measurements were compared to published results on the same tortoises observed prior to the installation of the heater (ZRH summer and winter trials), and on wild tortoises on Aldabra Atoll. The mean environmental temperature outside the heating area was 23. Read More

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November 2018

The Semiconductor/Conductor Interface Piezoresistive Effect in an Organic Transistor for Highly Sensitive Pressure Sensors.

Adv Mater 2018 Dec 13:e1805630. Epub 2018 Dec 13.

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Sciences, Tianjin University, Tianjin, 300072, China.

The piezoresistive pressure sensor, a kind of widely investigated artificial device to transfer force stimuli to electrical signals, generally consists of one or more kinds of conducting materials. Here, a highly sensitive pressure sensor based on the semiconductor/conductor interface piezoresistive effect is successfully demonstrated by using organic transistor geometry. Because of the efficient combination of the piezoresistive effect and field-effect modulation in a single sensor, this pressure sensor shows excellent performance, such as high sensitivity (514 kPa ), low limit of detection, short response and recovery time, and robust stability. Read More

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December 2018

Successful Physical Rehabilitation After Placement of a SynCardia Total Artificial Heart.

Artif Organs 2018 Dec 13. Epub 2018 Dec 13.

Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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December 2018

In vitro fertilisation/intracytoplasmic sperm injection beyond 2020.

BJOG 2019 Jan;126(2):237-243

The Royal Hospital for Women, Randwick, NSW, Australia.

Over 8 million babies have been born following IVF (in vitro fertilisation) and other artificial reproductive technology (ART) procedures since Louise Brown's birth 40 years ago. New innovations have added much complexity to both clinical and laboratory procedures over the last four decades. Translation of novel approaches from basic science into clinical practice continues unabated, widening the applicability of ART to new groups of people and helping improve both chances of healthy live birth and patient acceptability. Read More

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January 2019

Laparoscopic artificial urinary sphincter implantation in women with stress urinary incontinence: update on 13 years experience in a single center.

BJU Int 2018 Dec 11. Epub 2018 Dec 11.

Clinique du Pré, Dept of Urology, Technopôle Université, 13 Avenue René Laennec, 72018, Le Mans, France.

Introduction: Stress urinary incontinence (SUI) mainly affects women as a result of pregnancies with laborious delivery, obesity, and pelvic floor dysfunctions. The first therapeutic approach includes life-style interventions, pelvic floor muscle or bladder training. The second-line treatment usually is surgical. Read More

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December 2018

A Covalent Inhibitor for Glutathione S-Transferase Pi (GSTP1-1) in Human Cells.

Chembiochem 2018 Dec 7. Epub 2018 Dec 7.

Nagoya University, Department of Chemistry, Graduate School of Science, Furo, Chikusa, 464-8602, Nagoya, JAPAN.

Glutathione S-transferases (GSTs) are overexpressed in several cancers and are involved in drug resistance. Therefore, GSTs are an important target in cancer therapy and many GST inhibitors have been reported. We have developed an irreversible inhibitor, GS-ESF, as an effective GST inhibitor. Read More

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December 2018

Multi-modal optimization of bismuth vanadate photoanodes via combinatorial alloying and hydrogen processing.

Chem Commun (Camb) 2018 Dec 14. Epub 2018 Dec 14.

Joint Center for Artificial Photosynthesis, California Institute of Technology, Pasadena CA 91125, USA.

Alloying transition metals, such as Mo, into BiVO4 has emerged as the primary mechanism for improving carrier transport in this photoanode for solar fuels production. The present work establishes the generality of improving photoelectrochemical performance through co-alloying with a transition metal electron donor and a structure-modulating rare earth. Further improvement for all such alloys is obtained by annealing the oxide materials in H2, ultimately producing photoanodes with above 3 mA cm-2 photocurrent density under AM 1. Read More

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December 2018

Quantitative assessment and suppression of defect-induced scattering in low-loss mirrors.

Opt Lett 2018 Dec;43(24):6025-6028

In this Letter, defect-induced scattering in 1064 nm high-reflection coatings prepared by dual ion beam sputtering and its suppression were investigated by artificial nodules, finite-difference time-domain simulations, angular resolved scattering (ARS) measurements, and planarization technology. After establishing the geometric model of the nodules grown from ϕ 1 μm SiO microspheres, the far-field scattering of the multiple nodules was determined by intensity superposition. For a nodule density of 100  mm, there is good agreement between the simulated and measured ARS. Read More

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December 2018

Design and Clinical Evaluation of the Interoperable Artificial Pancreas System (iAPS) Smartphone App: Interoperable Components with Modular Design for Progressive Artificial Pancreas Research and Development.

Diabetes Technol Ther 2018 Dec 14. Epub 2018 Dec 14.

1 Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts.

Background: There is an unmet need for a modular artificial pancreas (AP) system for clinical trials within the existing regulatory framework to further AP research projects from both academia and industry. We designed, developed, and tested the interoperable artificial pancreas system (iAPS) smartphone app that can interface wirelessly with leading continuous glucose monitors (CGM), insulin pump devices, and decision-making algorithms while running on an unlocked smartphone.

Methods: After algorithm verification, hazard and mitigation analysis, and complete system verification of iAPS, six adults with type 1 diabetes completed 1 week of sensor-augmented pump (SAP) use followed by 48 h of AP use with the iAPS, a Dexcom G5 CGM, and either a Tandem or Insulet insulin pump in an investigational device exemption study. Read More

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December 2018

[Comprehensive approach for malnourished patients: aiming for continuity in nutritional support].

Nutr Hosp 2018 Apr 3;35(Spec no2):34-38. Epub 2018 Apr 3.

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days of hospitalization, a greater number of complementary tests, the need for artificial nutritional support and / or drugs to treat complications, which is a very important economic burden. Most patients who are malnourished, or at risk, can benefit from oral nutritional support, which includes dietary modifications (fortification, extra snacks, etc.), prescription of a personalized diet by a registered dietitian and the use of oral nutritional supplements (ONS). Read More

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[Innovation in the incorporation of macronutrients to enteral nutrition formulas].

Nutr Hosp 2018 Apr 3;35(Spec no2):4-12. Epub 2018 Apr 3.

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Enteral nutrition consists of the administration of chemically defined nutrients which are partially or fully metabolised in the intestinal tract, by the oral route or through a tube, to get an adequate and efficient nutritional supply. Enteral nutrition is the first option when one needs artificial nutrition, keeping parenteral nutrition only for those cases for which enteral nutrition would be insufficient or impossible. Enteral nutrition formulas are classified according to their composition with complete or uncompleted supply of nutrients, administration route, and protein content, energy density and type and content of fibre, and in second term according to general or special purposes utilization. Read More

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Long-term use of low-molecular-weight heparin in a patient with Heartware BIVAD (HVAD) with underlying sustained ventricular fibrillation.

J Cardiol Cases 2016 Dec 7;14(6):171-173. Epub 2016 Sep 7.

Division of Cardiovascular Surgery, Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada.

We report the case of a 59-year-old patient with Heartware (Framingham, MA, USA) biventricular assist device (BIVAD) implantation who had long-term sustained ventricular fibrillation and was managed on low-molecular-weight heparin for up to two years without any adverse events. The successful outcome in this case provides a clue that the long-term management of Heartware BIVADs with low-molecular-weight heparins could be a viable option even in patients with underlying malignant arrhythmias. < Long-term management of Heartware biventricular assist devices (BIVADs) using low-molecular-weight heparin is possible. Read More

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December 2016

Surgical repair of isolated anterior mitral leaflet cleft via right minithoracotomy.

J Cardiol Cases 2016 Jun 5;13(6):196-198. Epub 2016 Apr 5.

Department of Thoracic and Cardiovascular Surgery, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan.

Isolated anterior mitral leaflet cleft (AMLC) is rare. Several surgical procedures have been described; however, there are few reports which described mitral repair using minimally invasive cardiac surgery for AMLC. We describe successful repair for isolated AMLC via right minithoracotomy. Read More

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Birth of the Japanese Monkey (Macaca fuscata) infant following in-vitro fertilization and embryo transfer.

Primates 2000 Jan;41(1):39-47

Faculty of Human Sciences, Osaka University, Suita, 565-0871, Osaka, Japan.

The first successful birth by in-vitro fertilization (IVF) and embryo transfer (ET) in the Japanese monkey was described. IVF was carried out by using oocytes collected after ovarian stimulation and sperms collected by rectal electro-ejaculation. The embryos were incubated for 36-66 hours and then transferred to the fallopian tube of the recipient via the fimbria under laparoscopic observations. Read More

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January 2000

Urinary Metal Levels in a Chilean Community 31 Years After the Dumping of Mine Tailings.

J Health Pollut 2016 Jun 16;6(10):19-27. Epub 2016 Jun 16.

Departamento de Salud Pública, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Between 1938 and 1975, the city of Chañaral, located in the north of Chile, received 200 megatons of unregulated mining waste, which created an artificial beach 10 kilometers long and covering an area larger than 4 km. In 1983, this deposit was classified as a serious case of marine pollution in the Pacific Ocean, according to the Organization for Economic Cooperation and Development. In 1989, dumping ceased due to a judicial order. Read More

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The impact of the introduction of Artificial Intelligence to Ireland

Ir Med J 2018 09 10;111(8):799. Epub 2018 Sep 10.

Department of Radiology, Tallaght University Hospital, Dublin 24

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September 2018

Nerve grafting for peripheral nerve injuries with extended defect sizes.

Wien Med Wochenschr 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic and Reconstructive Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Artificial and non-artificial nerve grafts are the gold standard in peripheral nerve reconstruction in cases with extensive loss of nerve tissue, particularly where a direct end-to-end suture or an autologous nerve graft is inauspicious. Different materials are marketed and approved by the US Food and Drug Administration (FDA) for peripheral nerve graft reconstruction. The most frequently used materials are collagen and poly(DL-lactide-ε-caprolactone). Read More

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December 2018
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A Possible Prebiotic Ancestry of Porphyrin-Type Protein Cofactors.

Orig Life Evol Biosph 2018 Dec 13. Epub 2018 Dec 13.

Department of Bioinorganic Chemistry and Chemical Evolution, Institute of Chemistry, University of Hohenheim, Garbenstr. 30, 70599, Stuttgart, Germany.

In previous experiments that simulated conditions on primordial volcanic islands, we demonstrated the abiotic formation of hydrophobic porphyrins. The present study focused on the question whether such porphyrins can be metalated by prebiotically plausible metal ion sources. We used water-insoluble octaethylporphyrin (Hoep) as a model compound. Read More

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December 2018

Diagnosis using deep-learning artificial intelligence based on the endocytoscopic observation of the esophagus.

Esophagus 2018 Dec 13. Epub 2018 Dec 13.

AI Medical Service Inc., Tokyo, Japan.

Background And Aims: The endocytoscopic system (ECS) helps in virtual realization of histology and can aid in confirming histological diagnosis in vivo. We propose replacing biopsy-based histology for esophageal squamous cell carcinoma (ESCC) by using the ECS. We applied deep-learning artificial intelligence (AI) to analyse ECS images of the esophagus to determine whether AI can support endoscopists for the replacement of biopsy-based histology. Read More

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December 2018

Experimental exposure to gasohol impairs sperm quality with recognition of the classification pattern of exposure groups by machine learning algorithms.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Graduate Program in Environment and Regional Development, University of Western São Paulo - UNOESTE, Presidente Prudente, SP, 19067-175, Brazil.

Contamination caused by leakage at gas stations leads to possible exposure of the general population when in contact with contaminated water and soil. The present study aimed to evaluate the reproductive effects of exposure of adult male rats to gasohol and evaluate the performance of machine learning (ML) algorithms for pattern recognition and classification of the exposure groups. Rats were orally exposed to 0 (control), 16 (EA), 160 (EB), or 800 mg kg bw day of gasohol (EC), for 30 consecutive days. Read More

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December 2018

Foreign Body Reaction Associated With Artificial LARS Ligaments: A Retrieval Study.

Orthop J Sports Med 2018 Dec 4;6(12):2325967118811604. Epub 2018 Dec 4.

St John of God Hospital, Subiaco, Perth, Australia.

Background: Artificial ligaments have been developed and used in the treatment of ligamentous injuries since the 1970s. The early generation of artificial ligaments showed promising short-term results but resulted in high rates of rupture and inflammatory reaction in the surrounding tissues.

Purpose: To determine whether the use of Ligament Augmentation and Reconstruction System (LARS) ligaments is associated with the development of intra-articular foreign body reaction. Read More

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December 2018
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3D biofabrication for tubular tissue engineering.

Biodes Manuf 2018 23;1(2):89-100. Epub 2018 May 23.

1Department of Biomedical Engineering, University of Strathclyde, Glasgow, G1 1QE UK.

The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constructs have the potential to alleviate these concerns with reduced autoimmune response, high anatomical accuracy, long-term patency and growth potential. The advent of 3D bioprinting technology has further supplemented the technological toolbox, opening up new biofabrication research opportunities and expanding the therapeutic potential of the field. Read More

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Olefin metathesis catalysts embedded in β-barrel proteins: creating artificial metalloproteins for olefin metathesis.

Beilstein J Org Chem 2018 19;14:2861-2871. Epub 2018 Nov 19.

Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.

This review summarizes the recent progress of Grubbs-Hoveyda (GH) type olefin metathesis catalysts incorporated into the robust fold of β-barrel proteins. Anchoring strategies are discussed and challenges and opportunities in this emerging field are shown from simple small-molecule transformations over ring-opening metathesis polymerizations to in vivo olefin metathesis. Read More

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November 2018

Work and Organizational Psychology Looks at the Fourth Industrial Revolution: How to Support Workers and Organizations?

Front Psychol 2018 28;9:2365. Epub 2018 Nov 28.

Department of Psychology, University of Turin, Turin, Italy.

With rapid advances in technology in several fields of human life, we are entering the Fourth Industrial Revolution (FIR), which is changing the way businesses create value, people do their work and individuals interact and communicate with each other. In this framework, many questions have arisen about how these transformations affect workers, organizations and societies, and Work and Organizational Psychology (WOP) has been called upon to address some of these open issues. In particular, this article focuses on two aspects of the FIR. Read More

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November 2018

Predicting the Development of Normal-Appearing White Matter With Radiomics in the Aging Brain: A Longitudinal Clinical Study.

Front Aging Neurosci 2018 28;10:393. Epub 2018 Nov 28.

Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, China.

Normal-appearing white matter (NAWM) refers to the normal, yet diseased tissue around the white matter hyperintensities (WMH) on conventional MR images. Radiomics is an emerging quantitative imaging technique that provides more details than a traditional visual analysis. This study aims to explore whether WMH could be predicted during the early stages of NAWM, using a textural analysis in the general elderly population. Read More

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November 2018
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Lifelong Learning of Spatiotemporal Representations With Dual-Memory Recurrent Self-Organization.

Front Neurorobot 2018 28;12:78. Epub 2018 Nov 28.

Knowledge Technology, Department of Informatics, Universität Hamburg, Hamburg, Germany.

Artificial autonomous agents and robots interacting in complex environments are required to continually acquire and fine-tune knowledge over sustained periods of time. The ability to learn from continuous streams of information is referred to as and represents a long-standing challenge for neural network models due to in which novel sensory experience interferes with existing representations and leads to abrupt decreases in the performance on previously acquired knowledge. Computational models of lifelong learning typically alleviate catastrophic forgetting in experimental scenarios with given datasets of static images and limited complexity, thereby differing significantly from the conditions artificial agents are exposed to. Read More

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November 2018
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Fresh-blood-free diet for rearing malaria mosquito vectors.

Sci Rep 2018 Dec 13;8(1):17807. Epub 2018 Dec 13.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisboa, Portugal.

Mosquito breeding depends on the supply of fresh vertebrate blood, a major bottleneck for large-scale production of Anopheles spp. Feeding alternatives to fresh blood are thus a priority for research, outdoor large-cage trials and control interventions. Several artificial meal compositions were tested and Anopheles oogenesis, egg laying and development into the next generation of adult mosquitoes were followed. Read More

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December 2018

Using Psychological Artificial Intelligence (Tess) to Relieve Symptoms of Depression and Anxiety: Randomized Controlled Trial.

JMIR Ment Health 2018 Dec 13;5(4):e64. Epub 2018 Dec 13.

X2AI Inc, San Francisco, CA, United States.

Background: Students in need of mental health care face many barriers including cost, location, availability, and stigma. Studies show that computer-assisted therapy and 1 conversational chatbot delivering cognitive behavioral therapy (CBT) offer a less-intensive and more cost-effective alternative for treating depression and anxiety. Although CBT is one of the most effective treatment methods, applying an integrative approach has been linked to equally effective posttreatment improvement. Read More

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December 2018
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Stability and properties of Z-DNA containing artificial nucleobase 2'-O-methyl-8-methyl guanosine.

Bioorg Med Chem 2018 Dec 6. Epub 2018 Dec 6.

Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyo-take, Miyazaki 889-1692, Japan. Electronic address:

We synthesized several DNA oligonucleotides containing one or several 2'-O-methyl-8-methyl guanosine (mGm) and demonstrated that these oligonucleotides not only stabilize the Z-DNA with a wide range of sequences under low salt conditions but also possess high thermal stability. Using artificial nucleobase-containing oligonucleotides, we studied the interaction of the Zα domain with Z-DNA. Furthermore, we showed that the mGm-contained oligonucleotides allow to study the photochemical reaction of Z-DNA. Read More

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December 2018
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