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    1241 results match your criteria Artificial Intelligence in Medicine [Journal]

    1 OF 25

    Image processing strategies based on saliency segmentation for object recognition under simulated prosthetic vision.
    Artif Intell Med 2017 Nov 9. Epub 2017 Nov 9.
    School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
    Background And Objective: Current retinal prostheses can only generate low-resolution visual percepts constituted of limited phosphenes which are elicited by an electrode array and with uncontrollable color and restricted grayscale. Under this visual perception, prosthetic recipients can just complete some simple visual tasks, but more complex tasks like face identification/object recognition are extremely difficult. Therefore, it is necessary to investigate and apply image processing strategies for optimizing the visual perception of the recipients. Read More

    SSEL-ADE: A semi-supervised ensemble learning framework for extracting adverse drug events from social media.
    Artif Intell Med 2017 Oct 27. Epub 2017 Oct 27.
    School of Management, Hefei University of Technology, Hefei, Anhui, 230009, PR China. Electronic address:
    With the development of Web 2.0 technology, social media websites have become lucrative but under-explored data sources for extracting adverse drug events (ADEs), which is a serious health problem. Besides ADE, other semantic relation types (e. Read More

    Identifying Parkinson's Patients: A Functional Gradient Boosting Approach.
    Artif Intell Med (2017) 2017 Jun 30;10259:332-337. Epub 2017 May 30.
    Indiana University Bloomington.
    Parkinson's, a progressive neural disorder, is difficult to identify due to the hidden nature of the symptoms associated. We present a machine learning approach that uses a definite set of features obtained from the Parkinsons Progression Markers Initiative(PPMI) study as input and classifies them into one of two classes: PD(Parkinson's disease) and HC(Healthy Control). As far as we know this is the first work in applying machine learning algorithms for classifying patients with Parkinson's disease with the involvement of domain expert during the feature selection process. Read More

    Chaotic genetic algorithm and Adaboost ensemble metamodeling approach for optimum resource planning in emergency departments.
    Artif Intell Med 2017 Oct 17. Epub 2017 Oct 17.
    Industrial & Transportation Engineering Department, Universidade Federal do Rio Grande do Sul - UFRGS, 90035-190, Porto Alegre, RS, Brazil.
    Long length of stay and overcrowding in emergency departments (EDs) are two common problems in the healthcare industry. To decrease the average length of stay (ALOS) and tackle overcrowding, numerous resources, including the number of doctors, nurses and receptionists need to be adjusted, while a number of constraints are to be considered at the same time. In this study, an efficient method based on agent-based simulation, machine learning and the genetic algorithm (GA) is presented to determine optimum resource allocation in emergency departments. Read More

    Pronation and supination analysis based on biomechanical signals from Parkinson's disease patients.
    Artif Intell Med 2017 Oct 14. Epub 2017 Oct 14.
    Instituto Politécnico Nacional, Escuela Nacional de Medicina y Homeopatía, Guillermo Massieu, 07320 México City, Mexico.
    In this work, a fuzzy inference model to evaluate hands pronation/supination exercises during the MDS-UPDRS motor examination is proposed to analyze different extracted features from the bio-mechanical signals acquired from patients with Parkinson's disease (PD) in different stages of severity. Expert examiners perform visual assessments to evaluate several aspects of the disease. Some previous work on this subject does not contemplate the MDS-UPDRS guidelines. Read More

    Learning ensemble classifiers for diabetic retinopathy assessment.
    Artif Intell Med 2017 Oct 6. Epub 2017 Oct 6.
    Institute of Computing Sciences, Poznań University of Technology, 60-965 Poznań, Poland; Systems Research Institute, Polish Academy of Sciences, 01-447 Warsaw, Poland. Electronic address:
    Diabetic retinopathy is one of the most common comorbidities of diabetes. Unfortunately, the recommended annual screening of the eye fundus of diabetic patients is too resource-consuming. Therefore, it is necessary to develop tools that may help doctors to determine the risk of each patient to attain this condition, so that patients with a low risk may be screened less frequently and the use of resources can be improved. Read More

    Temporal case-based reasoning for type 1 diabetes mellitus bolus insulin decision support.
    Artif Intell Med 2017 Oct 3. Epub 2017 Oct 3.
    Oxford Brookes University, Oxford, United Kingdom. Electronic address:
    Individuals with type 1 diabetes have to monitor their blood glucose levels, determine the quantity of insulin required to achieve optimal glycaemic control and administer it themselves subcutaneously, multiple times per day. To help with this process bolus calculators have been developed that suggest the appropriate dose. However these calculators do not automatically adapt to the specific circumstances of an individual and require fine-tuning of parameters, a process that often requires the input of an expert. Read More

    Evaluation of an automated knowledge-based textual summarization system for longitudinal clinical data, in the intensive care domain.
    Artif Intell Med 2017 Oct 27;82:20-33. Epub 2017 Sep 27.
    Clalit Health Services, affiliated with the Hebrew University School of Medicine, Jerusalem, Israel.
    Objectives: To examine the feasibility of the automated creation of meaningful free-text summaries of longitudinal clinical records, using a new general methodology that we had recently developed; and to assess the potential benefits to the clinical decision-making process of using such a method to generate draft letters that can be further manually enhanced by clinicians.

    Methods: We had previously developed a system, CliniText (CTXT), for automated summarization in free text of longitudinal medical records, using a clinical knowledge base. In the current study, we created an Intensive Care Unit (ICU) clinical knowledge base, assisted by two ICU clinical experts in an academic tertiary hospital. Read More

    Single Nucleotide Polymorphism relevance learning with Random Forests for Type 2 diabetes risk prediction.
    Artif Intell Med 2017 Sep 21. Epub 2017 Sep 21.
    Biomedical Research Institute of Girona, Avda. de França, s/n, 17007 Girona, Spain; CIBERobn Pathophysiology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:
    Objective: The use of artificial intelligence techniques to find out which Single Nucleotide Polymorphisms (SNPs) promote the development of a disease is one of the features of medical research, as such techniques may potentially aid early diagnosis and help in the prescription of preventive measures. In particular, the aim is to help physicians to identify the relevant SNPs related to Type 2 diabetes, and to build a decision-support tool for risk prediction.

    Methods: We use the Random Forest (RF) technique in order to search for the most important attributes (SNPs) related to diabetes, giving a weight (degree of importance), ranging between 0 and 1, to each attribute. Read More

    Finding discriminative and interpretable patterns in sequences of surgical activities.
    Artif Intell Med 2017 Oct 22;82:11-19. Epub 2017 Sep 22.
    INSERM MediCIS, Unit U1099 LTSI, University of Rennes 1, Rennes, France. Electronic address:
    Objective: Surgery is one of the riskiest and most important medical acts that is performed today. Understanding the ways in which surgeries are similar or different from each other is of major interest to understand and analyze surgical behaviors. This article addresses the issue of identifying discriminative patterns of surgical practice from recordings of surgeries. Read More

    A hierarchical classifier based on human blood plasma fluorescence for non-invasive colorectal cancer screening.
    Artif Intell Med 2017 Oct 20;82:1-10. Epub 2017 Sep 20.
    Department of Industrial Engineering - Universidade Federal do Rio Grande do Sul, Av. Osvaldo Aranha, 99-5° andar, Porto Alegre, RS, Brazil. Electronic address:
    Colorectal cancer (CRC) a leading cause of death by cancer, and screening programs for its early identification are at the heart of the increasing survival rates. To motivate population participation, non-invasive, accurate, scalable and cost-effective diagnosis methods are required. Blood fluorescence spectroscopy provides rich information that can be used for cancer identification. Read More

    Reprint of "Updating Markov models to integrate cross-sectional and longitudinal studies".
    Artif Intell Med 2017 Sep 19;81:33-40. Epub 2017 Sep 19.
    Moorfields Eye Hospital and UCL Institute of Ophthalmology, University College London, UK.
    Clinical trials are typically conducted over a population within a defined time period in order to illuminate certain characteristics of a health issue or disease process. Cross-sectional studies provide a snapshot of these disease processes over a large number of people but do not allow us to model the temporal nature of disease, which is essential for modelling detailed prognostic predictions. Longitudinal studies, on the other hand, are used to explore how these processes develop over time in a number of people but can be expensive and time-consuming, and many studies only cover a relatively small window within the disease process. Read More

    Gaussian process classification of superparamagnetic relaxometry data: Phantom study.
    Artif Intell Med 2017 Oct 24;82:47-59. Epub 2017 Jul 24.
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, United States.
    Motivation: Superparamagnetic relaxometry (SPMR) is an emerging technology that holds potential for use in early cancer detection. Measurement of the magnetic field after the excitation of cancer-bound superparamagnetic iron oxide nanoparticles (SPIONs) enables the reconstruction of SPIONs spatial distribution and hence tumor detection. However, image reconstruction often requires solving an ill-posed inverse problem that is computationally challenging and sensitive to measurement uncertainty. Read More

    Gene2DisCo: Gene to disease using disease commonalities.
    Artif Intell Med 2017 Oct 4;82:34-46. Epub 2017 Sep 4.
    Università Degli Studi di Milano, Dipartimento di Informatica, Via Comelico 39/41, Milano, Italy. Electronic address:
    Objective: Finding the human genes co-causing complex diseases, also known as "disease-genes", is one of the emerging and challenging tasks in biomedicine. This process, termed gene prioritization (GP), is characterized by a scarcity of known disease-genes for most diseases, and by a vast amount of heterogeneous data, usually encoded into networks describing different types of functional relationships between genes. In addition, different diseases may share common profiles (e. Read More

    Owlready: Ontology-oriented programming in Python with automatic classification and high level constructs for biomedical ontologies.
    Artif Intell Med 2017 Jul 14;80:11-28. Epub 2017 Aug 14.
    LIMICS, Université Paris 13, Sorbonne Paris Cité, 93017 Bobigny, INSERM UMRS 1142, UPMC Université Paris 6, Sorbonne Universités, Paris, France. Electronic address:
    Objective: Ontologies are widely used in the biomedical domain. While many tools exist for the edition, alignment or evaluation of ontologies, few solutions have been proposed for ontology programming interface, i.e. Read More

    Change-Point Detection Method for Clinical Decision Support System Rule Monitoring.
    Artif Intell Med (2017) 2017 Jun 30;10259:126-135. Epub 2017 May 30.
    Department of Computer Science, University of Pittsburgh.
    A clinical decision support system (CDSS) and its components can malfunction due to various reasons. Monitoring the system and detecting its malfunctions can help one to avoid any potential mistakes and associated costs. In this paper, we investigate the problem of detecting changes in the CDSS operation, in particular its monitoring and alerting subsystem, by monitoring its rule firing counts. Read More

    A new preprocessing parameter estimation based on geodesic active contour model for automatic vestibular neuritis diagnosis.
    Artif Intell Med 2017 Jul 23;80:48-62. Epub 2017 Jul 23.
    University of Tunis, The National Engineering School of Tunis (ENSIT), Laboratory of Signal Image and Energy Mastery, LR13ES03 (SIME), Tunis, Tunisia. Electronic address:
    The diagnostic of the vestibular neuritis (VN) presents many difficulties to traditional assessment methods This paper deals with a fully automatic VN diagnostic system based on nystagmus parameter estimation using a pupil detection algorithm. A geodesic active contour model is implemented to find an accurate segmentation region of the pupil. Hence, the novelty of the proposed algorithm is to speed up the standard segmentation by using a specific mask located on the region of interest. Read More

    Machine learning based identification of protein-protein interactions using derived features of physiochemical properties and evolutionary profiles.
    Artif Intell Med 2017 May 13;78:61-71. Epub 2017 Jun 13.
    Department of Computer Science, Abdul Wali Khan University, Mardan, Pakistan. Electronic address:
    Proteins are the central constitute of a cell or biological system. Proteins execute their functions by interacting with other molecules such as RNA, DNA and other proteins. The major functionality of protein-protein interactions (PPIs) is the execution of biochemical activities in living species. Read More

    Automatic detection of surgical haemorrhage using computer vision.
    Artif Intell Med 2017 May 10;78:55-60. Epub 2017 Jun 10.
    Systems and Automatics Engineering Department, Miguel Hernández University, Avinguda de la Universitat d'Elx, Elche, 03202, Spain.
    Background And Objectives: On occasions, a surgical intervention can be associated with serious, potentially life-threatening complications. One of these complications is a haemorrhage during the operation, an unsolved issue that could delay the intervention or even cause the patient's death. On laparoscopic surgery this complication is even more dangerous, due to the limited vision and mobility imposed by the minimally invasive techniques. Read More

    Integration of data mining classification techniques and ensemble learning to identify risk factors and diagnose ovarian cancer recurrence.
    Artif Intell Med 2017 May 10;78:47-54. Epub 2017 Jun 10.
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Ovarian cancer is the second leading cause of deaths among gynecologic cancers in the world. Approximately 90% of women with ovarian cancer reported having symptoms long before a diagnosis was made. Literature shows that recurrence should be predicted with regard to their personal risk factors and the clinical symptoms of this devastating cancer. Read More

    Subcellular localization prediction of apoptosis proteins based on evolutionary information and support vector machine.
    Artif Intell Med 2017 May 24;78:41-46. Epub 2017 May 24.
    College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China; School of Mathematics and Statistics, Hainan Normal University, Haikou 571158, China. Electronic address:
    Objectives: In this paper, a high-quality sequence encoding scheme is proposed for predicting subcellular location of apoptosis proteins.

    Methods: In the proposed methodology, the novel evolutionary-conservative information is introduced to represent protein sequences. Meanwhile, based on the proportion of golden section in mathematics, position-specific scoring matrix (PSSM) is divided into several blocks. Read More

    Heart murmur detection based on wavelet transformation and a synergy between artificial neural network and modified neighbor annealing methods.
    Artif Intell Med 2017 May 13;78:23-40. Epub 2017 May 13.
    Department of Electrical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran. Electronic address:
    Early recognition of heart disease plays a vital role in saving lives. Heart murmurs are one of the common heart problems. In this study, Artificial Neural Network (ANN) is trained with Modified Neighbor Annealing (MNA) to classify heart cycles into normal and murmur classes. Read More

    Intelligent computational model for classification of sub-Golgi protein using oversampling and fisher feature selection methods.
    Artif Intell Med 2017 May 10;78:14-22. Epub 2017 May 10.
    Department of Computer Science, Abdul Wali Khan University, Mardan, Pakistan. Electronic address:
    Golgi is one of the core proteins of a cell, constitutes in both plants and animals, which is involved in protein synthesis. Golgi is responsible for receiving and processing the macromolecules and trafficking of newly processed protein to its intended destination. Dysfunction in Golgi protein is expected to cause many neurodegenerative and inherited diseases that may be cured well if they are detected effectively and timely. Read More

    Modeling new immunoregulatory therapeutics as antimicrobial alternatives for treating Clostridium difficile infection.
    Artif Intell Med 2017 May 9;78:1-13. Epub 2017 May 9.
    Nutritional Immunology and Molecular Medicine Laboratory(1), Biocomplexity Institute, Virginia Tech, Blacksburg, VA, United States. Electronic address:
    The current treatment paradigm in Clostridium difficile infection is the administration of antibiotics contributing to the high rates of recurrent infections. Recent alternative strategies, such as fecal microbiome transplantation and anti-toxin antibodies, have shown similar efficacy in the treatment of C. difficile associated disease (CDAD). Read More

    Detecting masses in dense breast using independent component analysis.
    Artif Intell Med 2017 Jul 26;80:29-38. Epub 2017 Jul 26.
    Biological Information Processing Lab, Federal University of Maranhao, Av. dos Portugueses, 1966 Sao Luis MA, Brazil. Electronic address:
    Breast cancer is the second type of cancer that most affects women in the world, losing only for non-melanoma skin cancer. Breast density can hinder the location of masses, especially in early stages. In this work, the use of independent component analysis for detecting lesions in dense breasts is proposed. Read More

    A machine learning approach for real-time modelling of tissue deformation in image-guided neurosurgery.
    Artif Intell Med 2017 Jul 24;80:39-47. Epub 2017 Jul 24.
    The Hamlyn Centre for Robotic Surgery, Imperial College London, SW7 2AZ London, United Kingdom.
    Objectives: Accurate reconstruction and visualisation of soft tissue deformation in real time is crucial in image-guided surgery, particularly in augmented reality (AR) applications. Current deformation models are characterised by a trade-off between accuracy and computational speed. We propose an approach to derive a patient-specific deformation model for brain pathologies by combining the results of pre-computed finite element method (FEM) simulations with machine learning algorithms. Read More

    Employing decomposable partially observable Markov decision processes to control gene regulatory networks.
    Artif Intell Med 2017 Jul 18. Epub 2017 Jul 18.
    Department of Computer Science, University of Calgary, Calgary, Alberta, Canada. Electronic address:
    Objective: Formulate the induction and control of gene regulatory networks (GRNs) from gene expression data using Partially Observable Markov Decision Processes (POMDPs).

    Methods And Material: Different approaches exist to model GRNs; they are mostly simulated as mathematical models that represent relationships between genes. Actually, it has been realized that biological functions at the cellular level are controlled by genes; thus, by controlling the behavior of genes, it is possible to regulate these biological functions. Read More

    Extract critical factors affecting the length of hospital stay of pneumonia patient by data mining (case study: an Iranian hospital).
    Artif Intell Med 2017 Jul 13. Epub 2017 Jul 13.
    K.N. Toosi University of Technology, Tehran, Iran. Electronic address:
    Motivation: Pneumonia is a prevalent infection of lower respiratory tract caused by infected lungs. Length of stay (LOS) in hospital is one of the simplest and most important indicators in hospital activity that is used for different purposes. The aim of this study is to explore the important factors affecting the LOS of patients with pneumonia in hospitals. Read More

    Personal sleep pattern visualization using sequence-based kernel self-organizing map on sound data.
    Artif Intell Med 2017 Jul 11;80:1-10. Epub 2017 Jul 11.
    Department of Architecture for Intelligence, The Institute of Scientific and Industrial Research, Osaka University, Japan.
    We propose a method to discover sleep patterns via clustering of sound events recorded during sleep. The proposed method extends the conventional self-organizing map algorithm by kernelization and sequence-based technologies to obtain a fine-grained map that visualizes the distribution and changes of sleep-related events. We introduced features widely applied in sound processing and popular kernel functions to the proposed method to evaluate and compare performance. Read More

    Medical image classification via multiscale representation learning.
    Artif Intell Med 2017 Jun 29;79:71-78. Epub 2017 Jun 29.
    Huibei Key Laboratory for Medical Information Analysis and Tumor Treatment, Wuhan 430074, PR China. Electronic address:
    Multiscale structure is an essential attribute of natural images. Similarly, there exist scaling phenomena in medical images, and therefore a wide range of observation scales would be useful for medical imaging measurements. The present work proposes a multiscale representation learning method via sparse autoencoder networks to capture the intrinsic scales in medical images for the classification task. Read More

    Premature ventricular contraction detection combining deep neural networks and rules inference.
    Artif Intell Med 2017 Jun 9;79:42-51. Epub 2017 Jun 9.
    Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, China. Electronic address:
    Premature ventricular contraction (PVC), which is a common form of cardiac arrhythmia caused by ectopic heartbeat, can lead to life-threatening cardiac conditions. Computer-aided PVC detection is of considerable importance in medical centers or outpatient ECG rooms. In this paper, we proposed a new approach that combined deep neural networks and rules inference for PVC detection. Read More

    iACP-GAEnsC: Evolutionary genetic algorithm based ensemble classification of anticancer peptides by utilizing hybrid feature space.
    Artif Intell Med 2017 Jun 17;79:62-70. Epub 2017 Jun 17.
    Department of Computer Science, Abdul Wali Khan University Mardan, KP 23200, Pakistan. Electronic address:
    Cancer is a fatal disease, responsible for one-quarter of all deaths in developed countries. Traditional anticancer therapies such as, chemotherapy and radiation, are highly expensive, susceptible to errors and ineffective techniques. These conventional techniques induce severe side-effects on human cells. Read More

    Random survival forest with space extensions for censored data.
    Artif Intell Med 2017 Jun 20;79:52-61. Epub 2017 Jun 20.
    School of Mathematics and Statistics, Central South University, China. Electronic address:
    Prediction capability of a classifier usually improves when it is built from an extended variable space by adding new variables from randomly combination of two or more original variables. However, its usefulness in survival analysis of censored time-to-event data is yet to be verified. In this research, we investigate the plausibility of space extension technique, originally proposed for classification purpose, to survival analysis. Read More

    Fully automated breast boundary and pectoral muscle segmentation in mammograms.
    Artif Intell Med 2017 Jun 9;79:28-41. Epub 2017 Jun 9.
    School of Health Sciences, Institute of Nursing and Health, Ulster University, Newtownabbey, N. Ireland BT37 0QB, United Kingdom.
    Breast and pectoral muscle segmentation is an essential pre-processing step for the subsequent processes in computer aided diagnosis (CAD) systems. Estimating the breast and pectoral boundaries is a difficult task especially in mammograms due to artifacts, homogeneity between the pectoral and breast regions, and low contrast along the skin-air boundary. In this paper, a breast boundary and pectoral muscle segmentation method in mammograms is proposed. Read More

    A hybrid framework for reverse engineering of robust Gene Regulatory Networks.
    Artif Intell Med 2017 Jun 9;79:15-27. Epub 2017 Jun 9.
    Department of Computer Engineering, Shahid Bahonar University of Kerman, Kerman, Iran. Electronic address:
    The inference of Gene Regulatory Networks (GRNs) using gene expression data in order to detect the basic cellular processes is a key issue in biological systems. Inferring GRN correctly requires inferring predictor set accurately. In this paper, a fast and accurate predictor set inference framework which linearly combines some inference methods is proposed. Read More

    Prediction of synergistic anti-cancer drug combinations based on drug target network and drug induced gene expression profiles.
    Artif Intell Med 2017 Jun 2. Epub 2017 Jun 2.
    Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, 1278 Keyuan Road, Shanghai 201203, PR China. Electronic address:
    Objective: Synergistic drug combinations are promising therapies for cancer treatment. However, effective prediction of synergistic drug combinations is quite challenging as mechanisms of drug synergism are still unclear. Various features such as drug response, and target networks may contribute to prediction of synergistic drug combinations. Read More

    Medical image classification based on multi-scale non-negative sparse coding.
    Artif Intell Med 2017 May 27. Epub 2017 May 27.
    School of Computer Science and Engineering, VIT University, Vellore, 632014, Tamilnadu, India. Electronic address:
    With the rapid development of modern medical imaging technology, medical image classification has become more and more important in medical diagnosis and clinical practice. Conventional medical image classification algorithms usually neglect the semantic gap problem between low-level features and high-level image semantic, which will largely degrade the classification performance. To solve this problem, we propose a multi-scale non-negative sparse coding based medical image classification algorithm. Read More

    Drug repositioning based on triangularly balanced structure for tissue-specific diseases in incomplete interactome.
    Artif Intell Med 2017 Mar 22;77:53-63. Epub 2017 Mar 22.
    School of Computer Science and Technology, Xidian University, Xi'an, 710071, PR China.
    Finding new uses for existing drugs has become a new strategy for decades to treat more patients. Few traditional approaches consider the tissue specificities of diseases. Moreover, disease genes, drug targets and protein interaction (PPI) networks remain largely incomplete and the relationships between drugs and diseases conform to the triangularly balanced structure. Read More

    Knowledge graph for TCM health preservation: Design, construction, and applications.
    Artif Intell Med 2017 Mar 21;77:48-52. Epub 2017 Apr 21.
    Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medicine Sciences, 16 Dongzhimen South Alley, Dongcheng District, Beijing, 100700, PR China.
    Traditional Chinese Medicine (TCM) is one of the important non-material cultural heritages of the Chinese nation. It is an important development strategy of Chinese medicine to collect, analyzes, and manages the knowledge assets of TCM health care. As a novel and massive knowledge management technology, knowledge graph provides an ideal technical means to solve the problem of "Knowledge Island" in the field of traditional Chinese medicine. Read More

    A case-based reasoning system based on weighted heterogeneous value distance metric for breast cancer diagnosis.
    Artif Intell Med 2017 Mar 11;77:31-47. Epub 2017 Feb 11.
    Sheldon B. Lubar School of Business, University of Wisconsin-Milwaukee, 3202 North Maryland Avenue, Milwaukee, WI, 53201, USA. Electronic address:
    Objective: We present the implementation and application of a case-based reasoning (CBR) system for breast cancer related diagnoses. By retrieving similar cases in a breast cancer decision support system, oncologists can obtain powerful information or knowledge, complementing their own experiential knowledge, in their medical decision making.

    Methods: We observed two problems in applying standard CBR to this context: the abundance of different types of attributes and the difficulty in eliciting appropriate attribute weights from human experts. Read More

    Updating Markov models to integrate cross-sectional and longitudinal studies.
    Artif Intell Med 2017 Mar 9;77:23-30. Epub 2017 Mar 9.
    Moorfields Eye Hospital and UCL Institute of Ophthalmology, University College London, UK.
    Clinical trials are typically conducted over a population within a defined time period in order to illuminate certain characteristics of a health issue or disease process. Cross-sectional studies provide a snapshot of these disease processes over a large number of people but do not allow us to model the temporal nature of disease, which is essential for modelling detailed prognostic predictions. Longitudinal studies, on the other hand, are used to explore how these processes develop over time in a number of people but can be expensive and time-consuming, and many studies only cover a relatively small window within the disease process. Read More

    Differential regulation analysis reveals dysfunctional regulatory mechanism involving transcription factors and microRNAs in gastric carcinogenesis.
    Artif Intell Med 2017 Mar 1;77:12-22. Epub 2017 Mar 1.
    Shanghai Center for Bioinformation Technology, Shanghai, China; Shanghai Industrial Technology Institute, Shanghai, China; Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, China. Electronic address:
    Gastric cancer (GC) is one of the most incident malignancies in the world. Although lots of featured genes and microRNAs (miRNAs) have been identified to be associated with gastric carcinogenesis, underlying regulatory mechanisms still remain unclear. In order to explore the dysfunctional mechanisms of GC, we developed a novel approach to identify carcinogenesis relevant regulatory relationships, which is characterized by quantifying the difference of regulatory relationships between stages. Read More

    Dynamically weighted evolutionary ordinal neural network for solving an imbalanced liver transplantation problem.
    Artif Intell Med 2017 Mar 20;77:1-11. Epub 2017 Feb 20.
    Department of Computer Science and Numerical Analysis, University of Córdoba, Campus Universitario de Rabanales, "Albert Einstein Building", Third Floor, 14071 Córdoba, Spain.
    Objective: Create an efficient decision-support model to assist medical experts in the process of organ allocation in liver transplantation. The mathematical model proposed here uses different sources of information to predict the probability of organ survival at different thresholds for each donor-recipient pair considered. Currently, this decision is mainly based on the Model for End-stage Liver Disease, which depends only on the severity of the recipient and obviates donor-recipient compatibility. Read More

    From SNOMED CT to Uberon: Transferability of evaluation methodology between similarly structured ontologies.
    Artif Intell Med 2017 Jun 19;79:9-14. Epub 2017 May 19.
    Computer Science Department, New Jersey Institute of Technology, Newark, NJ, USA.
    Objective: To examine whether disjoint partial-area taxonomy, a semantically-based evaluation methodology that has been successfully tested in SNOMED CT, will perform with similar effectiveness on Uberon, an anatomical ontology that belongs to a structurally similar family of ontologies as SNOMED CT.

    Method: A disjoint partial-area taxonomy was generated for Uberon. One hundred randomly selected test concepts that overlap between partial-areas were matched to a same size control sample of non-overlapping concepts. Read More

    Inter-labeler and intra-labeler variability of condition severity classification models using active and passive learning methods.
    Artif Intell Med 2017 Sep 27;81:12-32. Epub 2017 Apr 27.
    Department of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Biomedical Informatics, Columbia University, New York, NY, USA.
    Background And Objectives: Labeling instances by domain experts for classification is often time consuming and expensive. To reduce such labeling efforts, we had proposed the application of active learning (AL) methods, introduced our CAESAR-ALE framework for classifying the severity of clinical conditions, and shown its significant reduction of labeling efforts. The use of any of three AL methods (one well known [SVM-Margin], and two that we introduced [Exploitation and Combination_XA]) significantly reduced (by 48% to 64%) condition labeling efforts, compared to standard passive (random instance-selection) SVM learning. Read More

    Feasibility of spirography features for objective assessment of motor function in Parkinson's disease.
    Artif Intell Med 2017 Sep 31;81:54-62. Epub 2017 Mar 31.
    Ljubljana University Medical Centre, Department of Neurology, Zaloška 2, Ljubljana, Slovenia.
    Objective: Parkinson's disease (PD) is currently incurable, however proper treatment can ease the symptoms and significantly improve the quality of life of patients. Since PD is a chronic disease, its efficient monitoring and management is very important. The objective of this paper was to investigate the feasibility of using the features and methodology of a spirography application, originally designed to detect early Parkinson's disease (PD) motoric symptoms, for automatically assessing motor symptoms of advanced PD patients experiencing motor fluctuations. Read More

    Analyzing interactions on combining multiple clinical guidelines.
    Artif Intell Med 2017 Sep 11;81:78-93. Epub 2017 Apr 11.
    Department of Computer Science, Vrije Universiteit Amsterdam, The Netherlands.
    Accounting for patients with multiple health conditions is a complex task that requires analysing potential interactions among recommendations meant to address each condition. Although some approaches have been proposed to address this issue, important features still require more investigation, such as (re)usability and scalability. To this end, this paper presents an approach that relies on reusable rules for detecting interactions among recommendations coming from various guidelines. Read More

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