Structure 2022 May 17. Epub 2022 May 17.
TUM (Technical University of Munich), Department of Informatics, Bioinformatics and Computational Biology - i12, Boltzmannstr. 3, 85748 Garching/Munich, Germany; Institute for Advanced Study (TUM-IAS), Lichtenbergstr. 2a, 85748 Garching/Munich, Germany & TUM School of Life Sciences Weihenstephan (WZW), Alte Akademie 8, Freising, Germany.
Advanced protein structure prediction requires evolutionary information from multiple sequence alignments (MSAs) from evolutionary couplings that are not always available. Artificial intelligence (AI)-based predictions inputting only single sequences are faster but so inaccurate as to render speed irrelevant. Here, we described a competitive prediction of inter-residue distances (2D structure) exclusively inputting embeddings from pre-trained protein language models (pLMs), namely ProtT5, from single sequences into a convolutional neural network (CNN) with relatively few layers. Read More