99,020 results match your criteria Arthritis research & therapy[Journal]


Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease.

Food Chem Toxicol 2020 Jul 5:111558. Epub 2020 Jul 5.

Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow, Russia. Electronic address:

Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments - redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111558DOI Listing

High tolerance to instrument drifts by differential chemical isotope labeling LC-MS: A case study of the effect of LC leak in long-term sample runs on quantitative metabolome analysis.

J Mass Spectrom 2020 Jun 11:e4589. Epub 2020 Jun 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Metabolomics study of a biological system often involves the analysis of many comparative samples over a period of several days or weeks. This process of long-term sample runs can encounter unexpected instrument drifts such as small leaks in liquid chromatography-mass spectrometry (LC-MS), degradation of column performance, and MS signal intensity change. A robust analytical method should ideally tolerate these instrumental drifts as much as possible. Read More

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http://dx.doi.org/10.1002/jms.4589DOI Listing

Pain trajectory defines knee osteoarthritis subgroups: a prospective observational study.

Pain 2020 Jun 24. Epub 2020 Jun 24.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

Knee osteoarthritis (OA) is a heterogeneous disease, and identification of its subgroups/phenotypes can improve patient treatment and drug development. We aimed to identify homogeneous OA subgroups/phenotypes using pain development over time; to understand the interplay between pain and functional limitation in time course, and to investigate subgroups' responses to available pharmacological and surgical treatments. We used group-based trajectory modelling to identify pain trajectories in the phase-three VIDEO trial (n=474, three-year follow-up) and also in the Osteoarthritis Initiative cohort study (n=4796, nine-year follow-up). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001975DOI Listing

PD-1 mRNA expression in peripheral blood mononuclear cells as a biomarker for different stages of primary gouty arthritis.

J Cell Mol Med 2020 Jul 8. Epub 2020 Jul 8.

Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

There is currently a lack of biomarkers to assist the diagnosis and prediction of primary gouty arthritis (PG). Therefore, we evaluated the clinical value of programmed cell death protein 1 (PD-1) mRNA expression in peripheral blood mononuclear cells (PBMCs) of patients with PG. This study included 36 patients with acute phase PG (APPG), 48 with non-acute phase PG (NAPPG), 42 with asymptomatic hyperuricemia (AH) and 79 normal controls (NCs). Read More

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http://dx.doi.org/10.1111/jcmm.15582DOI Listing

Occupational risk in knee osteoarthritis: a systematic review and meta-analysis of observational studies.

Arthritis Care Res (Hoboken) 2020 Jul 7. Epub 2020 Jul 7.

Institute of Bone and Joint Research, Rheumatology Department, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.

Objectives: To assess the association between occupational exposures and knee osteoarthritis (OA).

Methods: We systematically searched for observational studies that examined the relationship between occupational exposures and, knee OA and total knee replacement (TKR). Four databases were searched until Oct 1 , 2019. Read More

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http://dx.doi.org/10.1002/acr.24333DOI Listing

Antibodies against three novel peptides in early axial spondyloarthritis patients from two independent cohorts.

Arthritis Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Hasselt, Belgium.

Objective: The aim of this study was to identify novel autoantibodies in axial spondyloarthritis (axSpA) and determine their diagnostic potential in early axSpA patients and controls from two independent cohorts.

Methods: An axSpA cDNA phage display library was used to screen for novel immunoglobulin G (IgG) antibodies in plasma of early axSpA patients. Presence of these antibodies against novel Hasselt University (UH)-axSpA peptides was determined in 76 early axSpA patients, 75 non-specific chronic low back pain (CLBP) controls, 60 rheumatoid arthritis (RA) patients and 94 healthy controls (HC) from the UH cohort using enzyme-linked immunosorbent assays (ELISA). Read More

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http://dx.doi.org/10.1002/art.41427DOI Listing

The association between exposure to childhood maltreatment and the subsequent development of functional somatic and visceral pain syndromes.

EClinicalMedicine 2020 Jun 6;23:100392. Epub 2020 Jun 6.

Midlands Health Data Research UK, University of Birmingham B152TT, United Kingdom.

Background: Childhood maltreatment is a global public health issue linked to a vast mortality and morbidity burden. This study builds on current literature to explore the risk of developing central sensitivity syndromes (CSS) (consisting of somatic and visceral pain syndromes) subsequent to childhood maltreatment exposure.

Methods: A retrospective population based open cohort study using the UK primary care database, 'The Health Improvement Network,' between 1st January 1995-31st December 2018. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329705PMC

First-year drug therapy of new-onset rheumatoid and undifferentiated arthritis: a nationwide register-based study.

BMC Rheumatol 2020 3;4:34. Epub 2020 Jul 3.

Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland.

Background: In this retrospective cohort study, we evaluated the drug therapies used for early rheumatoid (RA) and undifferentiated (UA) arthritis patients.

Methods: From a nationwide register maintained by the Social Insurance Institution, information on sex, date of birth, and date of special medicine reimbursement decision for all new Finnish RA and UA patients between 2011 and 14 were collected, and their DMARD (Disease Modifying Antirheumatic Drug) purchases during the first year after the diagnosis were analyzed.

Results: A total of 7338 patients with early RA (67. Read More

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http://dx.doi.org/10.1186/s41927-020-00127-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333434PMC

Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.

Sci Adv 2020 Jun 26;6(26):eaba4353. Epub 2020 Jun 26.

Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, La Jolla, CA 92093, USA.

Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted approaches could potentially be combined with DMARDs to improve control of RA without increasing immunosuppression. Read More

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http://dx.doi.org/10.1126/sciadv.aba4353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319753PMC

Sulfasalazine in dermatology: A lesser explored drug with broad therapeutic potential.

Int J Womens Dermatol 2020 Jun 13;6(3):191-198. Epub 2020 Feb 13.

Department of Dermatology, Venereology & Leprology, Maulana Azad Medical College, New Delhi, India.

Sulfasalazine is an aminosalicylate primarily used in the treatment of rheumatoid arthritis and ulcerative colitis. Its immunomodulatory, anti-inflammatory, and antiproliferative properties make it a potential therapeutic option for various dermatological disorders. Owing to its wide range of effects, it is often used off-label in dermatological diseases, such as alopecia areata, psoriasis and psoriatic arthritis, lichen planus, and pemphigus. Read More

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http://dx.doi.org/10.1016/j.ijwd.2020.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330441PMC

Whole-Body Magnetic Resonance Imaging Assessment of Joint Inflammation in Rheumatoid Arthritis-Agreement With Ultrasonography and Clinical Evaluation.

Front Med (Lausanne) 2020 19;7:285. Epub 2020 Jun 19.

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark.

To compare joint inflammation seen by whole-body magnetic resonance imaging (WBMRI), with "whole-body" ultrasound and clinical assessments, in patients with active rheumatoid arthritis (RA) before and during tumor necrosis factor-inhibitor (TNF-I, adalimumab) treatment. In 18 patients with RA, clinical assessment for joint tenderness and swelling, WBMRI, and ultrasound were obtained at baseline and week 16. Wrist, metacarpophalangeal (MCP) and proximal interphalangeal (PIP), elbow (except for WBMRI), shoulder, knee, ankle, and metatarsophalangeal joints were examined. Read More

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http://dx.doi.org/10.3389/fmed.2020.00285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317301PMC

Gonococcal osteomyelitis in a pediatric patient with disseminated gonococcal infection: Implications for antimicrobial management.

IDCases 2020 18;21:e00875. Epub 2020 Jun 18.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, New York, 11549, United States.

We report a case of a female teenager with gonococcal septic arthritis of the right shoulder that also caused osteomyelitis of the humeral head. Infection with is a frequently diagnosed sexually transmitted infection in the sexually active teenage population and disseminated gonococcal infection (DGI) is the most common systemic manifestation of acute gonorrhea. DGI commonly involves acute arthritis, tenosynovitis and dermatitis with less common complications of endocarditis, hepatitis and meningitis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327928PMC

Spirometry Utilization Among Patients with Asthma.

J Asthma Allergy 2020 30;13:193-203. Epub 2020 Jun 30.

Department of Medicine, UMMS-Baystate, Springfield, MA, USA.

Objective: To examine predictors of spirometry use at a tertiary academic health system and association between receipt of spirometry and outcomes.

Patients And Methods: We conducted a retrospective cohort study of adult patients with an ICD-9 CM diagnostic code for asthma and a 2014 outpatient visit in either a community health center or private practice associated with a tertiary academic medical center. The main outcome was receipt of spirometry during a 2007-2015 "exposure period. Read More

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http://dx.doi.org/10.2147/JAA.S254431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335289PMC

Comparative effectiveness of biological medicines in rheumatoid arthritis: systematic review and network meta-analysis including aggregate results from reanalysed individual patient data.

BMJ 2020 07 7;370:m2288. Epub 2020 Jul 7.

Drug Assessment Department, Institute for Quality and Efficiency in Health Care, Im Mediapark 8, Cologne 50670, Germany

Objective: To assess the comparative effectiveness of biological medicines in rheumatoid arthritis in sufficiently similar patient populations, based on the current definitions of key outcomes.

Design: Systematic review and network meta-analysis including aggregate results from reanalysed individual patient data.

Data Sources: Clinical study reports and aggregate results from reanalyses of individual patient data on key outcomes for rheumatoid arthritis provided by study sponsors for studies conducted up to 2017, and several databases and registries from inception up to February 2017. Read More

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http://dx.doi.org/10.1136/bmj.m2288DOI Listing

Baseball pitching biomechanics in relation to pain, injury, and surgery: A systematic review.

J Sci Med Sport 2020 Jul 1. Epub 2020 Jul 1.

Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Oxford, UK.

Objectives: To investigate the relationship between baseball pitching biomechanics and pain, injury, or surgery, in pitchers of all ages and competition levels.

Design: Systematic review.

Methods: This study was registered on Prospero (CRD42019137462). Read More

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http://dx.doi.org/10.1016/j.jsams.2020.06.015DOI Listing

Adoptive Treg cell-based immunotherapy: Frontier therapeutic aspects in rheumatoid arthritis.

Immunotherapy 2020 Jul 7. Epub 2020 Jul 7.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

The major current focus on treating rheumatoid arthritis is to put an end to long-term treatments and instead, specifically block widespread immunosuppression by developing antigen-specific tolerance, while also permitting an intact immune response toward other antigens to occur. There have been promising preclinical findings regarding adoptive Treg cells immunotherapy with a critically responsible function in the prevention of autoimmunity, tissue repair and regeneration, which make them an attractive candidate to develop effective therapeutic approaches to achieve this interesting concept in many human immune-mediated diseases, such as rheumatoid arthritis. or manipulation protocols are not only utilized to correct Treg cells defect, but also to benefit from their specific immunosuppressive properties by identifying specific antigens that are expressed in the inflamedjoint. Read More

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http://dx.doi.org/10.2217/imt-2020-0071DOI Listing

Notch-1 Signaling Modulates Macrophage Polarization and Immune Defense against Infection in Inflammatory Diseases.

Microorganisms 2020 Jul 5;8(7). Epub 2020 Jul 5.

Division of Molecular Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.

Despite the extensive research on Notch signaling involvement in inflammation, its specific role in macrophage response in autoimmune disease and defense mechanisms against bacterial infection, such as (MAP), remains unknown. In this study, we investigated the molecular role of Notch-1 signaling in the macrophage response during MAP infection. In particular, we measured the in vitro effect of MAP on Notch-1 signaling and downstream influence on interleukin (IL)-6 and myeloid cell leukemia sequence-1 (MCL-1) and consequent cellular apoptosis, MAP viability, and macrophage polarization. Read More

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http://dx.doi.org/10.3390/microorganisms8071006DOI Listing

Engineering an anti-granulocyte colony stimulating factor receptor nanobody for improved affinity.

Life Sci 2020 Jul 4:118052. Epub 2020 Jul 4.

Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Aims: Granulocyte colony-stimulating factor (G-CSF) is a cytokine that induces proliferation and differentiation of hematopoietic precursor cells and activation of mature neutrophils. G-CSF is overexpressed in several malignant tumors and blocking its binding to the receptor can lead to significant decrease in tumor growth, vascularization and metastasis. Furthermore, targeting G-CSF receptor has shown therapeutic benefit in other diseases such as rheumatoid arthritis, progressive neurodegenerative disorder and uveitis. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118052DOI Listing

Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients.

PLoS One 2020 7;15(7):e0235702. Epub 2020 Jul 7.

Division of Physiology, Pharmacology and Neuroscience, School of Life Science, University of Nottingham, Nottingham, England, United Kingdom.

Rheumatoid arthritis (RA) is accompanied by pain, inflammation and muscle weakness. Skeletal muscle inflammation and inactivity are independently associated with muscle insulin resistance and atrophy. Our objective was to identify early molecular and biochemical markers in muscle from a rodent model of RA relative to control and subsequently identify commonality in muscle gene expression between this model and muscle from RA patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235702PLOS

Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis.

J Am Geriatr Soc 2020 Jul 7. Epub 2020 Jul 7.

California Pacific Medical Research Institute, San Francisco, California, USA.

Background: The Sarcopenia Definitions and Outcomes Consortium (SDOC) sought to identify cut points for muscle strength and body composition measures derived from dual-energy x-ray absorptiometry (DXA) that discriminate older adults with slow walking speed. This article presents the core analyses used to guide the SDOC position statements.

Design: Cross-sectional data analyses of pooled data. Read More

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http://dx.doi.org/10.1111/jgs.16524DOI Listing

Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.

J Am Geriatr Soc 2020 Jul 7. Epub 2020 Jul 7.

Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Objectives: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht ); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality). Read More

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http://dx.doi.org/10.1111/jgs.16517DOI Listing

Men with type 2 diabetes mellitus have a lower detection rate of prostate cancer.

Int J Urol 2020 Jul 6. Epub 2020 Jul 6.

Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

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http://dx.doi.org/10.1111/iju.14304DOI Listing

NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation.

FASEB J 2020 Jul 7. Epub 2020 Jul 7.

Center for Research in Inflammatory Diseases, CRID, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Nucleotide oligomerization domain (NOD)-like receptor-12 (NLRP12) has emerged as a negative regulator of inflammation. It is well described that the Th17 cell population increases in patients with early Rheumatoid Arthritis (RA), which correlates with the disease activity. Here, we investigated the role of NLRP12 in the differentiation of Th17 cells and the development of experimental arthritis, using the antigen-induced arthritis (AIA) murine model. Read More

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http://dx.doi.org/10.1096/fj.202000795RDOI Listing

Blindness increases the risk for hip fracture and vertebral fracture but not the risk for distal radius fracture: a longitudinal follow-up study using a national sample cohort.

Osteoporos Int 2020 Jul 6. Epub 2020 Jul 6.

Department of Cornea, External Disease & Refractive Surgery, HanGil Eye Hospital, Catholic Kwandong University College of Medicine, 35 Bupyeong-daero, Bupyeong-gu, Incheon, 21388, Republic of Korea.

The risks for hip fracture and vertebral fracture, but not the risk for distal radius fracture, were significantly higher in the blindness group than in the control group with a maximum 12-year follow-up.

Purpose: To evaluate the influence of visual impairment on the risk for osteoporotic fractures at common sites: hip, thoracic/lumbar vertebra, and distal radius.

Methods: This longitudinal follow-up study used a database of a national sample cohort from 2002 to 2013 provided by the Korean National Health Insurance Service. Read More

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http://dx.doi.org/10.1007/s00198-020-05475-0DOI Listing

Neck pain in rheumatoid arthritis: a look beyond cervical spine involvement.

Rheumatology (Oxford) 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine, Clinical Immunology and Rheumatology Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/keaa308DOI Listing

Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis.

Cell Death Dis 2020 Jul 6;11(7):503. Epub 2020 Jul 6.

Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, P. R. China.

Spermidine has been known to inhibit the production of pro-inflammatory cytokines. However, there are no reports about anti-inflammatory effects of spermidine on osteoarthritis (OA). Herein, we examined whether OA progression could be delayed by intraperitoneal injection (i. Read More

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http://dx.doi.org/10.1038/s41419-020-2710-yDOI Listing

Response to: 'Comparative analysis of synovial inflammation after SARS-CoV-2 infection' by Alivernini .

Ann Rheum Dis 2020 Jul 6. Epub 2020 Jul 6.

Seccion de Reumatologia, Hospital General Universitario de Alicante, Alicante, Spain

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http://dx.doi.org/10.1136/annrheumdis-2020-218368DOI Listing

Sjögren Syndrome and Cancer.

Rheum Dis Clin North Am 2020 Aug;46(3):513-532

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA; US Department of Veterans Affairs, Oklahoma City, OK, USA. Electronic address:

The association between malignancy and rheumatic diseases has been demonstrated in a multitude of studies. Little is understood regarding the pathogenesis of rheumatic and musculoskeletal diseases in association with malignancy. There is strong evidence regarding the association between Sjögren syndrome and lymphoma as well as risk factors for development of lymphoma in these patients. Read More

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http://dx.doi.org/10.1016/j.rdc.2020.05.004DOI Listing

Cancer and Rheumatoid Arthritis.

Rheum Dis Clin North Am 2020 Aug 7;46(3):445-462. Epub 2020 Jun 7.

Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Unit 1444, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of General Internal Medicine, Section of Rheumatology and Clinical Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Management of rheumatoid arthritis (RA) in patients with cancer is complex and requires a multidisciplinary approach. A few studies have examined the risk for recurrence in patients with RA receiving disease-modifying antirheumatic drugs, primarily tumor necrosis factor-α inhibitors. Although these agents seem to be safe in patients with a history of cancer and no evidence of disease, additional information is needed to determine their potential effects in patients with RA and active cancer. Read More

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http://dx.doi.org/10.1016/j.rdc.2020.05.003DOI Listing

Profiling of IgG antibodies targeting unmodified and corresponding citrullinated autoantigens in a multicenter national cohort of early arthritis in Germany.

Arthritis Res Ther 2020 Jul 6;22(1):167. Epub 2020 Jul 6.

Department Rheumatology & Hiller Research Unit, UKD, Heinrich-Heine-University Düsseldorf, Merowingerplatz 1a, 40225, Düsseldorf, Germany.

Objective: To assess the diagnostic potential of IgG antibodies to citrullinated and corresponding native autoantigens in early arthritis.

Methods: IgG autoantibodies to 390 distinct unmodified and corresponding in vitro citrullinated recombinant proteins were measured by a multiplex assay in baseline blood samples from a German multicenter national cohort of 411 early arthritis patients (56.5 ± 14. Read More

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http://dx.doi.org/10.1186/s13075-020-02252-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336616PMC

Pulmonary Involvement in a Mouse Model of Sjögren's Syndrome Induced by STING Activation.

Int J Mol Sci 2020 Jun 25;21(12). Epub 2020 Jun 25.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Sjögren's Syndrome (SS), a chronic autoimmune disorder affecting multiple organ systems, is characterized by an elevated type I interferon (IFN) response. Activation of Stimulator of Interferon Genes (STING) protein induces type I IFN and in mice, several features of SS, including anti-nuclear antibodies, sialadenitis, and salivary gland dysfunction. Since lung involvement occurs in one-fifth of SS patients, we investigated whether systemic activation of STING also leads to lung inflammation. Read More

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http://dx.doi.org/10.3390/ijms21124512DOI Listing

The Geometry of the roots of the Brachial Plexus.

J Anat 2020 Jul 6. Epub 2020 Jul 6.

Leeds Institute for Medical Research, University of Leeds, Leeds, UK.

Diffusion tensor magnetic resonance imaging (DTI) can be used to reconstruct the brachial plexus in 3D via tracts connecting contiguous diffusion tensors with similar primary eigenvector orientations. When creating DTI tractograms, the turning angle of connecting lines (step angle) must be prescribed by the user; however, the literature is lacking detailed geometry of brachial plexus to inform such decisions. Therefore, the spinal cord and brachial plexus of 10 embalmed adult cadavers were exposed bilaterally by posterior dissection. Read More

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http://dx.doi.org/10.1111/joa.13270DOI Listing

A systematic review and evidence synthesis of non-medical triage, self-referral and direct access services for patients with musculoskeletal pain.

PLoS One 2020 6;15(7):e0235364. Epub 2020 Jul 6.

Arthritis Research UK Primary Care Centre, School of Primary, Community & Social Care, Keele University, Keele, United Kingdom.

Introduction: The demand for musculoskeletal (MSK) care is rising, and is a growing challenge for general practice. Direct access to physiotherapy and other healthcare services may offer appropriate care for MSK pain patients but there is uncertainty regarding the effectiveness or efficiency of this approach in practice. This study aimed to review the evidence regarding characteristics, outcomes, barriers and facilitators of MSK triage and direct access services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235364PLOS
July 2020
3.234 Impact Factor

Characterization of Patients With Axial Spondyloarthritis by Enthesitis Presence: Data from the Corrona Psoriatic Arthritis/Spondyloarthritis Registry.

ACR Open Rheumatol 2020 Jul 6. Epub 2020 Jul 6.

University of Pennsylvania, Philadelphia, Pennsylvania.

Objective: To compare the characteristics of patients with axial spondyloarthritis (axSpA) who had enthesitis versus those without enthesitis.

Methods: This study included adult patients with axSpA enrolled in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry (March 2013 to August 2018). Enthesitis was assessed at enrollment via the Spondyloarthritis Research Consortium of Canada Enthesitis Index. Read More

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http://dx.doi.org/10.1002/acr2.11154DOI Listing

Altered properties of endothelial cells and mesenchymal stem cells underlying the development of scleroderma-like vasculopathy in Klf5 ;Fli1 mice.

Arthritis Rheumatol 2020 Jul 6. Epub 2020 Jul 6.

Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Objective: We previously established a new animal model (Klf5 ;Fli1 mice) broadly recapitulating fundamental pathologic features of systemic sclerosis (SSc). SSc vasculopathy is believed to occur as a result of impaired vascular remodeling, but its detailed mechanism has remained unknown. To address this issue, we investigated the properties of dermal microvascular endothelial cells (DMECs), bone marrow-derived endothelial progenitor cells (BM-EPCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs), a precursor of pericytes, in Klf5 ;Fli1 mice. Read More

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http://dx.doi.org/10.1002/art.41423DOI Listing

[Mechanism prediction of Simiao Yongan Decoction in treatment of psoriasis arthritis based on network pharmacology].

Authors:
Di Ma Gui-Qin Ma

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(11):2611-2618

Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.

To explore the main target and signal pathway of Simiao Yongan Decoction in the treatment of psoriatic arthritis(PsA) by network pharmacology, so as to reveal the intervention mechanism of Simiao Yongan Decoction in the treatment of psoriatic arthritis. The platform of pharmacology technology of traditional Chinese medicine system(TCMSP) was used to predict and screen the active ingredients of Simiao Yongan Decoction, and GeneCards database was searched to obtain the disease target related to the psoriatic arthritis. Protein interaction network model was constructed with STRING platform; drug-component-target-disease network map was constructed with Cytoscape Software; Wayne Diagram of common target of Simiao Yongan Decoction and psoriasis arthritis was drawn with the help of ClusterProfiler R Software. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200225.401DOI Listing

A Randomized, Double-Blind Study Comparing Pharmacokinetics and Pharmacodynamics of Proposed Biosimilar ABP 798 With Rituximab Reference Product in Subjects With Moderate to Severe Rheumatoid Arthritis.

Clin Pharmacol Drug Dev 2020 Jul 5. Epub 2020 Jul 5.

Metroplex Clinical Research Center, Dallas, Texas, USA.

ABP 798 is a proposed biosimilar to rituximab reference product (RP), an anti-CD20 monoclonal antibody. Pharmacokinetics (PK), pharmacodynamics (PD), and safety results from the comparative clinical study that evaluated the PK, PD, safety, efficacy, and immunogenicity of ABP 798 versus rituximab RP are presented here. Subjects with moderate to severe rheumatoid arthritis (RA) received 2 doses of ABP 798, United States-sourced RP (rituximab US) or European Union-sourced RP (rituximab EU), each consisting of two 1000-mg infusions 2 weeks apart. Read More

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http://dx.doi.org/10.1002/cpdd.845DOI Listing

Spinal muscular atrophy and Farber disease due to ASAH1 variants: A case report.

Am J Med Genet A 2020 Jul 5. Epub 2020 Jul 5.

Department of Neurology, University of Rochester, Rochester, New York, USA.

Genetic variations in the ASAH1 gene are associated with a spectrum of disorders ranging from Farber disease (FD) to spinal muscular atrophy with or without progressive myoclonic epilepsy (SMA-PME). FD presents most commonly in infants with subcutaneous joint nodules, progressive arthritis and granulomas of the larynx and epiglottis leading to a hoarse cry. SMA-PME is characterized by childhood onset progressive weakness due to motor neuron disease followed by progressive epilepsy, tremor, and sensorineural hearing loss. Read More

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http://dx.doi.org/10.1002/ajmg.a.61764DOI Listing

Study on Genotyping Polymorphism and Sequencing of N-Acetyltransferase 2 (NAT2) among Al-Ahsa Population.

Biomed Res Int 2020 15;2020:8765347. Epub 2020 Jun 15.

Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, 31982 Al-Ahsa, Saudi Arabia.

One of the well-studied phase II drug metabolizing enzymes is N-acetyltransferase 2 () which has an essential role in the detoxification and metabolism of several environmental toxicants and many therapeutic drugs like isoniazid (antituberculosis, TB) and antimicrobial sulfonamides. According to the variability in the acetylation rate among different ethnic groups, individuals could be classified into slow, intermediate, and fast acetylators; these variabilities in the acetylation rate are a result of single nucleotide polymorphisms (SNPs) in the coding sequence of . The variety of acetylation status is associated with some diseases such as bladder cancer, colorectal cancer, rheumatoid arthritis, and diabetes mellitus. Read More

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http://dx.doi.org/10.1155/2020/8765347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312966PMC

Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis.

Arthritis Care Res (Hoboken) 2020 Jul 5. Epub 2020 Jul 5.

Department of Rheumatology, the third Affiliated Hospital of SUN YAT-SEN University, Guangzhou, China.

Objectives: This study aims to determine whether vitamin D supplementation or maintaining sufficient vitamin D level reduces foot pain over two years in patients with symptomatic knee OA.

Methods: A post hoc study was conducted from a randomized double-blind placebo-controlled trial named the VItamin D Effect on Osteoarthritis (VIDEO) study. Symptomatic knee OA patients with serum 25-hydroxyvitamin D levels between 12. Read More

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http://dx.doi.org/10.1002/acr.24371DOI Listing

Cutaneous lupus erythematosus and cardiovascular disease: current knowledge and insights into pathogenesis.

Clin Rheumatol 2020 Jul 5. Epub 2020 Jul 5.

Harvard Medical School, Boston, MA, USA.

Multiple autoinflammatory diseases, including psoriasis, psoriatic arthritis, and systemic lupus erythematosus, have been linked to increased risk of cardiovascular disease. Inflammation is known to play a key role in the pathogenesis of atherosclerosis, thus the contribution of systemic immune dysregulation, which characterizes such inflammatory conditions, towards the development of cardiovascular disease has garnered considerable interest. Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease, but risk of cardiovascular disease amongst patients with cutaneous lupus is less well known. Read More

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http://dx.doi.org/10.1007/s10067-020-05257-3DOI Listing

Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study.

Microvasc Res 2020 Jul 2:104038. Epub 2020 Jul 2.

Departiment of Biomedical Sciences, University of Sassari, Sassari, Italy.

Background: The relationship between plasma arginine metabolites influencing vascular homeostasis and peripheral vasodilatory capacity in rheumatoid arthritis (RA) patients is not known.

Methods: l-arginine (Arg), monomethyl-l-arginine (MMA), l-homoarginine (hArg), asymmetric dimethyl-l-arginine (ADMA), symmetric dimethyl-l-arginine, and l-citrulline (Cit) were measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) in 164 RA patients and 100 age- and sex-matched healthy controls without previous cardiovascular events. Log-transformed reactive hyperemia index (Ln-RHI) evaluated by flow-mediated pulse amplitude tonometry (PAT, EndoPAT2000 device) was assessed as surrogate measure of peripheral vasodilatory capacity in RA patients. Read More

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http://dx.doi.org/10.1016/j.mvr.2020.104038DOI Listing

Quality of life outcomes in patients undergoing knee replacement surgery: longitudinal findings from the QPro-Gin study.

BMC Musculoskelet Disord 2020 Jul 4;21(1):436. Epub 2020 Jul 4.

National Research Council, Neuroscience Institute - Aging Branch, via Giustiniani, 2, 35128, Padova, Italy.

Background: Many patients report postoperative pain, limited improvement in physical function and poor quality of life (QOL) after knee replacement surgery. Our study uses baseline predictors of change to investigate the QOL of patients with knee osteoarthritis 3-months after knee replacement surgery.

Methods: A prospective observational study was designed to evaluate patients (n = 132) scheduled for uni-compartmental or total knee replacement surgery who were assessed at baseline (preoperatively) and 3-months after. Read More

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http://dx.doi.org/10.1186/s12891-020-03456-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335448PMC

Editorial: Psoriatic arthritis; overcoming the challenges by creating opportunities.

Clin Immunol 2020 Jul 1:108519. Epub 2020 Jul 1.

Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Sacramento, CA 95616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2020.108519DOI Listing

Galantamine in rheumatoid arthritis: A cross talk of parasympathetic and sympathetic system regulates synovium-derived microRNAs and related pathogenic pathways.

Eur J Pharmacol 2020 Jul 1:173315. Epub 2020 Jul 1.

Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.

The acetylcholinesterase inhibitor, galantamine, has shown therapeutic effect in rat model of rheumatoid arthritis. Hence, the current study aims at determining the mode of action of galantamine by examining different synovium-derived microRNAs (miRs) and their related pathogenic pathways. The study also focuses on how parasympathetic and sympathetic pathways in the synovial tissue could affect the mode of action and anti-arthritic effect of galantamine. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173315DOI Listing

Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts; MyungSung Christian Medical Center (MCM) Eye Unit, MCM General Hospital and MyungSung Medical School, Addis Ababa, Ethiopia.

Purpose: To evaluate the risk/risk factors for exudative retinal detachment (ERD) in ocular inflammatory diseases.

Design: Retrospective cohort study.

Methods: Patients with non-infectious ocular inflammation had been followed longitudinally between 1978-2007 at four US subspecialty uveitis centers. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.019DOI Listing

Ultrasound versus dual-energy computed tomography in patients with different stages of acute gouty arthritis: methodological issues on diagnostic value.

Authors:
Siamak Sabour

Clin Rheumatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Clinical Epidemiology, School of Public Health and Safety, Safety Promotion and Injury Prevention Research Center, Shahid Beheshti University of Medical Sciences, Chamran Highway, Velenjak, Daneshjoo Blvd., Tehran, IR, 1983535511, Iran.

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http://dx.doi.org/10.1007/s10067-020-05067-7DOI Listing

EQ-5D: a plea for accurate nomenclature.

J Patient Rep Outcomes 2020 Jul 3;4(1):52. Epub 2020 Jul 3.

EuroQol Group Research Foundation, Marten Meesweg 107, 3068, AV, Rotterdam, The Netherlands.

Between 1987 and 1990, the EuroQol Group developed a 5-dimension health-related quality of life instrument, originally known as 'the EuroQol instrument', which since 1995 has been called the 'EQ-5D'. For several years, 'the EuroQol instrument' and 'EQ-5D' were both deployed in published materials. In order to standardise nomenclature, the EuroQol Group agreed in 2001 on a terminology glossary containing 12 items; this was recently revised and augmented to include 22 items and can be found on the Group's website ( www. Read More

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http://dx.doi.org/10.1186/s41687-020-00222-9DOI Listing

Changing the outcome measures, changing the results? The urgent need of a specific disease activity score to adult-onset Still's disease.

Ann Rheum Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Clinical Sciences and Applied Biotechnology, University of L'Aquila, L'Aquila, Abruzzo, Italy

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http://dx.doi.org/10.1136/annrheumdis-2020-218032DOI Listing