336,883 results match your criteria Arthritis care and research : the official journal of the Arthritis Health Professions Association[Journal]


Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease.

Food Chem Toxicol 2020 Jul 5:111558. Epub 2020 Jul 5.

Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow, Russia. Electronic address:

Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments - redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111558DOI Listing

Autoimmune Conditions: Rheumatoid Arthritis.

Authors:
Robert C Langan

FP Essent 2020 07;494:11-17

St. Luke's Family Medicine Residency, 2830 Easton Ave, Bethlehem, PA 18017.

Rheumatoid arthritis (RA) is the most common autoimmune inflammatory arthritis, and is seen more commonly in women, smokers, and individuals with a family history of RA. It should be considered if unexplained pain and swelling in the metacarpophalangeal and/or metatarsophalangeal joints and morning stiffness of fingers lasting for longer than 30 minutes are present. RA may be present in the lungs, skin, and eyes. Read More

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High tolerance to instrument drifts by differential chemical isotope labeling LC-MS: A case study of the effect of LC leak in long-term sample runs on quantitative metabolome analysis.

J Mass Spectrom 2020 Jun 11:e4589. Epub 2020 Jun 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Metabolomics study of a biological system often involves the analysis of many comparative samples over a period of several days or weeks. This process of long-term sample runs can encounter unexpected instrument drifts such as small leaks in liquid chromatography-mass spectrometry (LC-MS), degradation of column performance, and MS signal intensity change. A robust analytical method should ideally tolerate these instrumental drifts as much as possible. Read More

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http://dx.doi.org/10.1002/jms.4589DOI Listing

Surgical dislocation or the modified Heuter anterior approach for Pipkin I and II femoral head fracture dislocations.

J Orthop Trauma 2020 Jun 29. Epub 2020 Jun 29.

Objectives: To compare outcomes after surgical treatment of Pipkin I and II femoral head fractures treated with either a surgical dislocation (SD) or a direct anterior approach (The Modified Heuter Approach) STUDY DESIGN:: Retrospective, multi - centre SETTING:: Three Level I trauma care centres PATIENTS:: 49 patients operated for Pipkin types I or II femoral head fractures. 27 - using SD and 22 - using modified Heuter approach.

Interventions: Initial closed reduction of the joint followed by open reduction and internal fixation of the fracture/ fragment excision. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001877DOI Listing

Pain trajectory defines knee osteoarthritis subgroups: a prospective observational study.

Pain 2020 Jun 24. Epub 2020 Jun 24.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

Knee osteoarthritis (OA) is a heterogeneous disease, and identification of its subgroups/phenotypes can improve patient treatment and drug development. We aimed to identify homogeneous OA subgroups/phenotypes using pain development over time; to understand the interplay between pain and functional limitation in time course, and to investigate subgroups' responses to available pharmacological and surgical treatments. We used group-based trajectory modelling to identify pain trajectories in the phase-three VIDEO trial (n=474, three-year follow-up) and also in the Osteoarthritis Initiative cohort study (n=4796, nine-year follow-up). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001975DOI Listing

A transcriptional toolbox for exploring peripheral neuro-immune interactions.

Pain 2020 Jun 24. Epub 2020 Jun 24.

Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Guy's Campus, London, SE1 1UL, United Kingdom.

Correct communication between immune cells and peripheral neurons is crucial for the protection of our bodies. Its breakdown is observed in many common, often painful conditions, including arthritis, neuropathies and inflammatory bowel or bladder disease. Here, we have characterised the immune response in a mouse model of neuropathic pain using flow cytometry and cell-type specific RNA sequencing (RNA-seq). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001914DOI Listing

Ankle Arthrodesis Through an Anterior Approach.

J Orthop Trauma 2020 Aug;34 Suppl 2:S42-S43

Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI.

Ankle arthritis occurs primarily because of trauma and has a huge impact on patient's quality of life. Ankle arthrodesis is indicated for patients with end-stage ankle arthritis who fail conservative management. High rates of fusion can be achieved through an anterior approach. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001838DOI Listing

Outcomes of Polyvinyl Alcohol Hydrogel Implant of the Lesser Metatarsals.

Foot Ankle Int 2020 Jul 8:1071100720935034. Epub 2020 Jul 8.

Hospital for Special Surgery, New York, NY, USA.

Background: Lesser toe metatarsophalangeal (MTP) joint pathology presents a challenge for surgical treatment. At our institution, arthroplasty using a polyvinyl alcohol (PVA) hydrogel implant has been utilized in the second and third MTP joints for advanced arthritis, failed management of Freiberg's infraction, and osteochondral defects. We present a case series describing the clinical outcomes of 13 patients following PVA implantation of the second or third MTP. Read More

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http://dx.doi.org/10.1177/1071100720935034DOI Listing

PD-1 mRNA expression in peripheral blood mononuclear cells as a biomarker for different stages of primary gouty arthritis.

J Cell Mol Med 2020 Jul 8. Epub 2020 Jul 8.

Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

There is currently a lack of biomarkers to assist the diagnosis and prediction of primary gouty arthritis (PG). Therefore, we evaluated the clinical value of programmed cell death protein 1 (PD-1) mRNA expression in peripheral blood mononuclear cells (PBMCs) of patients with PG. This study included 36 patients with acute phase PG (APPG), 48 with non-acute phase PG (NAPPG), 42 with asymptomatic hyperuricemia (AH) and 79 normal controls (NCs). Read More

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http://dx.doi.org/10.1111/jcmm.15582DOI Listing

Pachydermodactyly associated with extensive computer gaming: A report of three cases.

Pediatr Dermatol 2020 Jul 8. Epub 2020 Jul 8.

Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Pachydermodactyly is an uncommon, progressive, nontender thickening of the fingers with prominent involvement of the proximal interphalangeal joints. Pachydermodactyly mimics inflammatory arthritis but plain film radiography is normal in this condition. Pachydermodactyly has been previously described in workers performing manual labor. Read More

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http://dx.doi.org/10.1111/pde.14271DOI Listing

Occupational risk in knee osteoarthritis: a systematic review and meta-analysis of observational studies.

Arthritis Care Res (Hoboken) 2020 Jul 7. Epub 2020 Jul 7.

Institute of Bone and Joint Research, Rheumatology Department, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.

Objectives: To assess the association between occupational exposures and knee osteoarthritis (OA).

Methods: We systematically searched for observational studies that examined the relationship between occupational exposures and, knee OA and total knee replacement (TKR). Four databases were searched until Oct 1 , 2019. Read More

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http://dx.doi.org/10.1002/acr.24333DOI Listing

The role of the non-neuronal cholinergic system in inflammation and degradation processes in osteoarthritis.

Arthritis Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Sorbonne Université, Paris, France.

Objectives: The non-neuronal cholinergic system represents non-neuronal cells that have the biochemical machinery to synthetize de novo and/or respond to acetylcholine (ACh). We investigated this biochemical machinery in chondrocytes and its involvement in osteoarthritis (OA).

Methods: Expression of the biochemical machinery for ACh metabolism and nicotinic ACh receptors (nAChR), particularly α7nAChR, in human OA and murine chondrocytes was determined by PCR and ligand-binding. Read More

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http://dx.doi.org/10.1002/art.41429DOI Listing

Antibodies against three novel peptides in early axial spondyloarthritis patients from two independent cohorts.

Arthritis Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Hasselt, Belgium.

Objective: The aim of this study was to identify novel autoantibodies in axial spondyloarthritis (axSpA) and determine their diagnostic potential in early axSpA patients and controls from two independent cohorts.

Methods: An axSpA cDNA phage display library was used to screen for novel immunoglobulin G (IgG) antibodies in plasma of early axSpA patients. Presence of these antibodies against novel Hasselt University (UH)-axSpA peptides was determined in 76 early axSpA patients, 75 non-specific chronic low back pain (CLBP) controls, 60 rheumatoid arthritis (RA) patients and 94 healthy controls (HC) from the UH cohort using enzyme-linked immunosorbent assays (ELISA). Read More

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http://dx.doi.org/10.1002/art.41427DOI Listing

Efficacy and Safety of Upadacitinib Monotherapy in Methotrexate-naïve Patients with Moderately to Severely Active Rheumatoid Arthritis (SELECT-EARLY): A Randomized, Double-blind, Active-comparator, Multi-center, Multi-country Trial.

Arthritis Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Stanford University, Palo Alto, CA, USA.

Objective: The SELECT-EARLY trial studied the effect of upadacitinib, an oral, reversible, JAK inhibitor, as monotherapy in patients with predominantly early rheumatoid arthritis who are naïve or have limited exposure to methotrexate.

Methods: Patients were randomized (n=947, 1:1:1) to once-daily upadacitinib (15mg or 30mg) or weekly methotrexate (7.5-20mg/week) for 24 weeks. Read More

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http://dx.doi.org/10.1002/art.41384DOI Listing

Impeding factors of early rehabilitation postoperatively after rheumatoid toe arthroplasty: a single-center retrospective cohort study.

JA Clin Rep 2020 Jul 7;6(1):50. Epub 2020 Jul 7.

Department of Anesthesiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan.

Introduction: Previous studies explored the benefits related to early ambulation postoperatively, but few focused on patients with rheumatoid arthritis (RA). We retrospectively evaluated the incidence and predictors of the inability to begin walking on the first postoperative day (POD) after toe arthroplasty for rheumatoid arthritis.

Methods: RA patients who underwent toe arthroplasty at one hospital were retrospectively reviewed. Read More

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http://dx.doi.org/10.1186/s40981-020-00356-1DOI Listing

The genetics of rheumatoid arthritis.

Authors:
Laura E Dedmon

Rheumatology (Oxford) 2020 Jul 8. Epub 2020 Jul 8.

UCL Medical School, London, UK.

RA is a chronic systemic inflammatory disease that primarily affects the small joints of the hands and feet, and results in a mean reduction in life expectancy of 3-10 years. RA is a multigene disorder with a substantial genetic component and a heritability estimate of 60%. Large-scale Genome-Wide Association Studies (GWAS) and meta-analyses have revealed common disease-associated variants in the population that may contribute cumulatively to RA pathogenesis. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa232DOI Listing

The Validity and Sensitivity of Rheumatoid Arthritis Pain Scale on a Different Ethnic Group From Indian Rheumatoid Arthritis Patients.

Arch Rheumatol 2020 Mar 6;35(1):90-96. Epub 2019 Nov 6.

Department of General Medicine, K C G M C, Karnal, India.

Objectives: This study aims to assess pain in rheumatoid arthritis (RA) patients by using Rheumatoid Arthritis Pain Scale (RAPS) and to find its correlation with Disease Activity Score 28 (DAS28) and Clinical Disease Activity Index (CDAI).

Patients And Methods: The study included 100 RA patients (23 males, 77 females; mean age 43.22 years; range, 19 to 72 years) who were subjected to RAPS questionnaire for pain assessment and DAS28 and CDAI for disease activity assessment. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2020.7348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322297PMC

The association between exposure to childhood maltreatment and the subsequent development of functional somatic and visceral pain syndromes.

EClinicalMedicine 2020 Jun 6;23:100392. Epub 2020 Jun 6.

Midlands Health Data Research UK, University of Birmingham B152TT, United Kingdom.

Background: Childhood maltreatment is a global public health issue linked to a vast mortality and morbidity burden. This study builds on current literature to explore the risk of developing central sensitivity syndromes (CSS) (consisting of somatic and visceral pain syndromes) subsequent to childhood maltreatment exposure.

Methods: A retrospective population based open cohort study using the UK primary care database, 'The Health Improvement Network,' between 1st January 1995-31st December 2018. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329705PMC

First-year drug therapy of new-onset rheumatoid and undifferentiated arthritis: a nationwide register-based study.

BMC Rheumatol 2020 3;4:34. Epub 2020 Jul 3.

Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland.

Background: In this retrospective cohort study, we evaluated the drug therapies used for early rheumatoid (RA) and undifferentiated (UA) arthritis patients.

Methods: From a nationwide register maintained by the Social Insurance Institution, information on sex, date of birth, and date of special medicine reimbursement decision for all new Finnish RA and UA patients between 2011 and 14 were collected, and their DMARD (Disease Modifying Antirheumatic Drug) purchases during the first year after the diagnosis were analyzed.

Results: A total of 7338 patients with early RA (67. Read More

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http://dx.doi.org/10.1186/s41927-020-00127-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333434PMC

Cerebral arteriopathy associated with heterozygous variants in the casitas B-lineage lymphoma gene.

Neurol Genet 2020 Aug 10;6(4):e448. Epub 2020 Jun 10.

UCL Great Ormond Street Institute of Child Health (Y.H., A.K., B.J., T.S.J., E.O., D.S., V.G., P.A.B., D.E.); Histopathology Department (O.O.), Great Ormond Street Hospital, London; Paediatric Neurology Department (A.A.M.), and Genetics Department (M.T., R.N.-E.), Bristol Royal Hospital for Children; Genetics Department (J.R.), Royal Devon and Exeter NHS Foundation Trust, Exeter; Centre for Translational Omics-GOSgene (H.J.W.), UCL GOS Institute of Child Health; and Centre for Adolescent Rheumatology Versus Arthritis (D.E.), London, United Kingdom.

Objective: To report a series of patients with cerebral arteriopathy associated with heterozygous variants in the casitas B-lineage lymphoma () gene and examine the functional role of the identified mutant Cbl protein. We hypothesized that mutated Cbl fails to act as a negative regulator of the RAS-mitogen-activated protein kinases (MAPK) signaling pathway, resulting in enhanced vascular fibroblast proliferation and migration and enhanced angiogenesis and collateral vessel formation.

Methods: We performed whole-exome sequencing in 11 separate families referred to Great Ormond Street Hospital, London, with suspected genetic cause for clinical presentation with severe progressive cerebral arteriopathy. Read More

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http://dx.doi.org/10.1212/NXG.0000000000000448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323481PMC

Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.

Sci Adv 2020 Jun 26;6(26):eaba4353. Epub 2020 Jun 26.

Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, La Jolla, CA 92093, USA.

Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted approaches could potentially be combined with DMARDs to improve control of RA without increasing immunosuppression. Read More

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http://dx.doi.org/10.1126/sciadv.aba4353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319753PMC

Sulfasalazine in dermatology: A lesser explored drug with broad therapeutic potential.

Int J Womens Dermatol 2020 Jun 13;6(3):191-198. Epub 2020 Feb 13.

Department of Dermatology, Venereology & Leprology, Maulana Azad Medical College, New Delhi, India.

Sulfasalazine is an aminosalicylate primarily used in the treatment of rheumatoid arthritis and ulcerative colitis. Its immunomodulatory, anti-inflammatory, and antiproliferative properties make it a potential therapeutic option for various dermatological disorders. Owing to its wide range of effects, it is often used off-label in dermatological diseases, such as alopecia areata, psoriasis and psoriatic arthritis, lichen planus, and pemphigus. Read More

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http://dx.doi.org/10.1016/j.ijwd.2020.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330441PMC

Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge.

Mol Ther Methods Clin Dev 2020 Sep 6;18:215-229. Epub 2020 Jun 6.

Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China.

Circular RNAs (circRNAs) are a new class of noncoding single-stranded RNAs that differ from linear microRNAs (miRNAs), since they form covalently closed loop structures without free 3' poly(A) tails or 5' caps. circRNAs are the competitive endogenous RNAs (ceRNAs) by binding to miRNA through miRNA response elements (MREs) (i.e. Read More

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http://dx.doi.org/10.1016/j.omtm.2020.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326721PMC
September 2020

Real Life Efficacy and Safety of Secukinumab in Biologic-Experienced Patients With Psoriatic Arthritis.

Front Med (Lausanne) 2020 19;7:288. Epub 2020 Jun 19.

Clinical Immunology-Rheumatology Unit, 2nd Department of Medicine and Laboratory, Hippokration General Hospital, Athens, Greece.

Real world evidence data regarding secukinumab (SEC) use in biologic-experienced patients with psoriatic arthritis (PsA) are scarce. To assess the real life survival, safety and efficacy of SEC in biologic-experienced patients with PsA. All biologic-experienced PsA patients treated with SEC in 2 University Rheumatology Units were included (3/2016-12/2018). Read More

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http://dx.doi.org/10.3389/fmed.2020.00288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317305PMC

Whole-Body Magnetic Resonance Imaging Assessment of Joint Inflammation in Rheumatoid Arthritis-Agreement With Ultrasonography and Clinical Evaluation.

Front Med (Lausanne) 2020 19;7:285. Epub 2020 Jun 19.

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark.

To compare joint inflammation seen by whole-body magnetic resonance imaging (WBMRI), with "whole-body" ultrasound and clinical assessments, in patients with active rheumatoid arthritis (RA) before and during tumor necrosis factor-inhibitor (TNF-I, adalimumab) treatment. In 18 patients with RA, clinical assessment for joint tenderness and swelling, WBMRI, and ultrasound were obtained at baseline and week 16. Wrist, metacarpophalangeal (MCP) and proximal interphalangeal (PIP), elbow (except for WBMRI), shoulder, knee, ankle, and metatarsophalangeal joints were examined. Read More

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http://dx.doi.org/10.3389/fmed.2020.00285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317301PMC

Osteoclast Signal Transduction During Bone Metastasis Formation.

Front Cell Dev Biol 2020 19;8:507. Epub 2020 Jun 19.

Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Osteoclasts are myeloid lineage-derived bone-resorbing cells of hematopoietic origin. They differentiate from myeloid precursors through a complex regulation process where the differentiation of preosteoclasts is followed by intercellular fusion to generate large multinucleated cells. Under physiological conditions, osteoclastogenesis is primarily directed by interactions between CSF-1R and macrophage colony-stimulating factor (M-CSF, CSF-1), receptor activator of nuclear factor NF-κB (RANK) and RANK ligand (RANKL), as well as adhesion receptors (e. Read More

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http://dx.doi.org/10.3389/fcell.2020.00507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317091PMC

Gonococcal osteomyelitis in a pediatric patient with disseminated gonococcal infection: Implications for antimicrobial management.

IDCases 2020 18;21:e00875. Epub 2020 Jun 18.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, New York, 11549, United States.

We report a case of a female teenager with gonococcal septic arthritis of the right shoulder that also caused osteomyelitis of the humeral head. Infection with is a frequently diagnosed sexually transmitted infection in the sexually active teenage population and disseminated gonococcal infection (DGI) is the most common systemic manifestation of acute gonorrhea. DGI commonly involves acute arthritis, tenosynovitis and dermatitis with less common complications of endocarditis, hepatitis and meningitis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327928PMC

Invasive Thymoma with Right Upper Lobe Endobronchial Lesion and Autoimmune Enteropathy.

Case Rep Pulmonol 2020 20;2020:6396915. Epub 2020 Jun 20.

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Thymomas are slow-growing neoplasia arising from the epithelial cells of the thymus that usually present with respiratory symptoms, superior vena cava syndrome, or parathymic syndromes. Approximately 30% of thymomas develop myasthenia gravis. An additional 5% of patients with thymomas have other systemic syndromes, including rheumatoid arthritis, thyroiditis, red cell aplasia, systemic lupus erythematosus, and Cushing syndrome. Read More

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http://dx.doi.org/10.1155/2020/6396915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322609PMC

Spirometry Utilization Among Patients with Asthma.

J Asthma Allergy 2020 30;13:193-203. Epub 2020 Jun 30.

Department of Medicine, UMMS-Baystate, Springfield, MA, USA.

Objective: To examine predictors of spirometry use at a tertiary academic health system and association between receipt of spirometry and outcomes.

Patients And Methods: We conducted a retrospective cohort study of adult patients with an ICD-9 CM diagnostic code for asthma and a 2014 outpatient visit in either a community health center or private practice associated with a tertiary academic medical center. The main outcome was receipt of spirometry during a 2007-2015 "exposure period. Read More

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http://dx.doi.org/10.2147/JAA.S254431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335289PMC

Comparative effectiveness of biological medicines in rheumatoid arthritis: systematic review and network meta-analysis including aggregate results from reanalysed individual patient data.

BMJ 2020 07 7;370:m2288. Epub 2020 Jul 7.

Drug Assessment Department, Institute for Quality and Efficiency in Health Care, Im Mediapark 8, Cologne 50670, Germany

Objective: To assess the comparative effectiveness of biological medicines in rheumatoid arthritis in sufficiently similar patient populations, based on the current definitions of key outcomes.

Design: Systematic review and network meta-analysis including aggregate results from reanalysed individual patient data.

Data Sources: Clinical study reports and aggregate results from reanalyses of individual patient data on key outcomes for rheumatoid arthritis provided by study sponsors for studies conducted up to 2017, and several databases and registries from inception up to February 2017. Read More

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http://dx.doi.org/10.1136/bmj.m2288DOI Listing

Baseball pitching biomechanics in relation to pain, injury, and surgery: A systematic review.

J Sci Med Sport 2020 Jul 1. Epub 2020 Jul 1.

Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Oxford, UK.

Objectives: To investigate the relationship between baseball pitching biomechanics and pain, injury, or surgery, in pitchers of all ages and competition levels.

Design: Systematic review.

Methods: This study was registered on Prospero (CRD42019137462). Read More

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http://dx.doi.org/10.1016/j.jsams.2020.06.015DOI Listing

[CME-Rheuma 21: Precision Medicine - Synovial Biopsy in Rheumatology].

Praxis (Bern 1994) 2020 Jul;109(9):687-692

UZR®, Schweizer Ultraschallzentrum und Institut für Rheumatologie, Basel.

CME-Rheuma 21: Precision Medicine - Synovial Biopsy in Rheumatology Synovial biopsy is increasingly performed in the medicine of the musculoskeletal system. On the one hand it allows the in-depth diagnosis of unclear arthritides. On the other hand, there is an increasing body of publications showing that histology, immunohistochemistry and RNA analysis of synovial tissue may lead to subclassifications within rheumatoid arthritis. Read More

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http://dx.doi.org/10.1024/1661-8157/a003513DOI Listing

Adoptive Treg cell-based immunotherapy: Frontier therapeutic aspects in rheumatoid arthritis.

Immunotherapy 2020 Jul 7. Epub 2020 Jul 7.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

The major current focus on treating rheumatoid arthritis is to put an end to long-term treatments and instead, specifically block widespread immunosuppression by developing antigen-specific tolerance, while also permitting an intact immune response toward other antigens to occur. There have been promising preclinical findings regarding adoptive Treg cells immunotherapy with a critically responsible function in the prevention of autoimmunity, tissue repair and regeneration, which make them an attractive candidate to develop effective therapeutic approaches to achieve this interesting concept in many human immune-mediated diseases, such as rheumatoid arthritis. or manipulation protocols are not only utilized to correct Treg cells defect, but also to benefit from their specific immunosuppressive properties by identifying specific antigens that are expressed in the inflamedjoint. Read More

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http://dx.doi.org/10.2217/imt-2020-0071DOI Listing

Esomeprazole During Pregnancy and Lactation: Esomeprazole Levels in Maternal Serum, Cord Blood, Breast Milk, and the Infant's Serum.

Breastfeed Med 2020 Jul 7. Epub 2020 Jul 7.

Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Tokyo, Japan.

Esomeprazole is the -isomer of omeprazole and is used to treat stomach acid-related diseases. Most data regarding the safety of esomeprazole during pregnancy are derived from studies on omeprazole, and the data characterizing esomeprazole transfer across the placenta and excretion into breast milk are limited. In this report, we discuss the safety of esomeprazole with reference to drug concentrations in maternal and neonatal blood and breast milk. Read More

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http://dx.doi.org/10.1089/bfm.2020.0175DOI Listing

JAK-Inhibitors for the Treatment of Rheumatoid Arthritis: A Focus on the Present and an Outlook on the Future.

Biomolecules 2020 Jul 5;10(7). Epub 2020 Jul 5.

Head of Clinical Pharmacology and Toxicology Unit, Grande Ospedale Metropolitano Niguarda, Department of Oncology and Onco-Hematology, Director of Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan, 20162 Milan, Italy.

Janus kinase inhibitors (JAKi) belong to a new class of oral targeted disease-modifying drugs which have recently revolutionized the therapeutic panorama of rheumatoid arthritis (RA) and other immune-mediated diseases, placing alongside or even replacing conventional and biological drugs. JAKi are characterized by a novel mechanism of action, consisting of the intracellular interruption of the JAK-STAT pathway crucially involved in the immune response. The aim of this narrative review is to globally report the most relevant pharmacological features and clinical outcomes of the developed and incoming JAKi for RA, based on the available preclinical and clinical evidence. Read More

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http://dx.doi.org/10.3390/biom10071002DOI Listing

Notch-1 Signaling Modulates Macrophage Polarization and Immune Defense against Infection in Inflammatory Diseases.

Microorganisms 2020 Jul 5;8(7). Epub 2020 Jul 5.

Division of Molecular Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.

Despite the extensive research on Notch signaling involvement in inflammation, its specific role in macrophage response in autoimmune disease and defense mechanisms against bacterial infection, such as (MAP), remains unknown. In this study, we investigated the molecular role of Notch-1 signaling in the macrophage response during MAP infection. In particular, we measured the in vitro effect of MAP on Notch-1 signaling and downstream influence on interleukin (IL)-6 and myeloid cell leukemia sequence-1 (MCL-1) and consequent cellular apoptosis, MAP viability, and macrophage polarization. Read More

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http://dx.doi.org/10.3390/microorganisms8071006DOI Listing

Identification of Novel Molecular Markers of Human Th17 Cells.

Cells 2020 Jul 3;9(7). Epub 2020 Jul 3.

Laboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, Poland.

Th17 cells are important players in host defense against pathogens such as , , and . Th17 cell-mediated inflammation, under certain conditions in which balance in the immune system is disrupted, is the underlying pathogenic mechanism of certain autoimmune disorders, e.g. Read More

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http://dx.doi.org/10.3390/cells9071611DOI Listing

T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria.

iScience 2020 Jun 24;23(7):101310. Epub 2020 Jun 24.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0435, USA; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435, USA. Electronic address:

Hybrid Th1/Tfh cells (IFN-γIL-21CXCR5) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ T cells control parasitemia, whereas antibody and IL-21Bcl6 T cells effect final clearance, suggesting an evolutionary driver for the hybrid population. We found that CD4-intrinsic Bcl6, Blimp-1, and STAT3 coordinately regulate expression of the Th1 master regulator T-bet, supporting plasticity of CD4 T cells. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101310DOI Listing

Engineering an anti-granulocyte colony stimulating factor receptor nanobody for improved affinity.

Life Sci 2020 Jul 4:118052. Epub 2020 Jul 4.

Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Aims: Granulocyte colony-stimulating factor (G-CSF) is a cytokine that induces proliferation and differentiation of hematopoietic precursor cells and activation of mature neutrophils. G-CSF is overexpressed in several malignant tumors and blocking its binding to the receptor can lead to significant decrease in tumor growth, vascularization and metastasis. Furthermore, targeting G-CSF receptor has shown therapeutic benefit in other diseases such as rheumatoid arthritis, progressive neurodegenerative disorder and uveitis. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118052DOI Listing

Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients.

PLoS One 2020 7;15(7):e0235702. Epub 2020 Jul 7.

Division of Physiology, Pharmacology and Neuroscience, School of Life Science, University of Nottingham, Nottingham, England, United Kingdom.

Rheumatoid arthritis (RA) is accompanied by pain, inflammation and muscle weakness. Skeletal muscle inflammation and inactivity are independently associated with muscle insulin resistance and atrophy. Our objective was to identify early molecular and biochemical markers in muscle from a rodent model of RA relative to control and subsequently identify commonality in muscle gene expression between this model and muscle from RA patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235702PLOS

The role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases.

Curr Pharm Des 2020 Jul 7. Epub 2020 Jul 7.

Institute of Immunology, Faculty of Medicine, Central University of Venezuela, 50109, Los Chaguaramos 1050-A, Caracas. Venezuela.

Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of the heterocyclic aromatic compound quinoline. These economical compounds were used as antimalarial agents for many years. Currently, they are used as monotherapy or in conjunction with other therapies for the treatment of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS) and antiphospholipid antibody syndrome (APS). Read More

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http://dx.doi.org/10.2174/1381612826666200707132920DOI Listing

Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis.

J Am Geriatr Soc 2020 Jul 7. Epub 2020 Jul 7.

California Pacific Medical Research Institute, San Francisco, California, USA.

Background: The Sarcopenia Definitions and Outcomes Consortium (SDOC) sought to identify cut points for muscle strength and body composition measures derived from dual-energy x-ray absorptiometry (DXA) that discriminate older adults with slow walking speed. This article presents the core analyses used to guide the SDOC position statements.

Design: Cross-sectional data analyses of pooled data. Read More

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http://dx.doi.org/10.1111/jgs.16524DOI Listing

Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.

J Am Geriatr Soc 2020 Jul 7. Epub 2020 Jul 7.

Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Objectives: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht ); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality). Read More

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http://dx.doi.org/10.1111/jgs.16517DOI Listing

Mildly Processed Natural Eggshell Membrane Alleviates Joint Pain Associated with Osteoarthritis of the Knee: A Randomized Double-Blind Placebo-Controlled Study.

J Med Food 2020 Jul 6. Epub 2020 Jul 6.

Applegg, Amersfoort, The Netherlands.

Poor joint health is a significant burden to society. Millions of people suffer from some form of joint-related disorder or disease, most often osteoarthritis (OA). It was hypothesized that chicken eggshell membrane (EM) is effective in the regeneration of cartilage and/or immunomodulation (oral tolerance), and as such relieves pain and stiffness in joints commonly affected in arthritis. Read More

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http://dx.doi.org/10.1089/jmf.2020.0034DOI Listing

The management of acute fracture dislocations of proximal interphalangeal joints: a systematic review.

J Plast Surg Hand Surg 2020 Jul 7:1-5. Epub 2020 Jul 7.

Pulvertaft Hand Centre, Royal Derby Hospital.

A systematic review was conducted to identify the best management for acute proximal interphalangeal joint fracture-dislocations. A study protocol was designed in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Due to limited data in the primary assessment, the hypothesis was tested in a secondary analysis of articles that marginally met the inclusion criteria (i. Read More

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http://dx.doi.org/10.1080/2000656X.2020.1788041DOI Listing

Covid-19 related IgA vasculitis.

Arthritis Rheumatol 2020 Jul 6. Epub 2020 Jul 6.

Department of Virology, Hôpital Saint-Louis, APHP, Université de Paris, Paris, France.

IgA vasculitis is a systemic small-vessel vasculitis which may be triggered by different microorganisms. IgA vasculitis cases have been reported in patients with immune-mediated inflammatory disorders treated with TNF inhibitors. Here we report the case of a young Crohn's disease patient in clinical remission under adalimumab admitted for an IgA vasculitis, with an extended ileitis, and a positive PCR testing for Covid-19. Read More

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http://dx.doi.org/10.1002/art.41428DOI Listing

Men with type 2 diabetes mellitus have a lower detection rate of prostate cancer.

Int J Urol 2020 Jul 6. Epub 2020 Jul 6.

Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

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http://dx.doi.org/10.1111/iju.14304DOI Listing

NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation.

FASEB J 2020 Jul 7. Epub 2020 Jul 7.

Center for Research in Inflammatory Diseases, CRID, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Nucleotide oligomerization domain (NOD)-like receptor-12 (NLRP12) has emerged as a negative regulator of inflammation. It is well described that the Th17 cell population increases in patients with early Rheumatoid Arthritis (RA), which correlates with the disease activity. Here, we investigated the role of NLRP12 in the differentiation of Th17 cells and the development of experimental arthritis, using the antigen-induced arthritis (AIA) murine model. Read More

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http://dx.doi.org/10.1096/fj.202000795RDOI Listing

Radiosynthesis and evaluation of [F]FMTP, a COX-2 PET ligand.

Pharmacol Rep 2020 Jul 6. Epub 2020 Jul 6.

Department of Radiology, Columbia University Medical Center, Manhattan, NY, USA.

Background: The upregulation of cyclooxygenase-2 (COX-2) is involved in neuroinflammation associated with many neurological diseases as well as cancers of the brain. Outside the brain, inflammation and COX-2 induction contribute to the pathogenesis of pain, arthritis, acute allograft rejection, and in response to infections, tumors, autoimmune disorders, and injuries. Herein, we report the radiochemical synthesis and evaluation of [F]6-fluoro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine ([F]FMTP), a high-affinity COX-2 inhibitor, by cell uptake and PET imaging studies. Read More

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http://dx.doi.org/10.1007/s43440-020-00124-zDOI Listing

Autoantibody Production in Obesity: Is There Evidence for a Link Between Obesity and Autoimmunity?

Curr Obes Rep 2020 Jul 6. Epub 2020 Jul 6.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527, Athens, Greece.

Purpose Of Review: During the last decades, obesity and autoimmune disorders have shown a parallel significant rise in industrialized countries. This review aims at providing a comprehensive update of the relationship between the adipose tissue in obesity and autoimmune disorders, highlighting the underlying mechanisms with a particular emphasis on adipokines and pro-inflammatory cytokines, the impaired B cell activity, and the production of natural and pathogenic autoantibody repertoire in the context of obesity.

Recent Findings: Obesity is related to a higher risk of rheumatoid arthritis, psoriasis and psoriatic arthritis, multiple sclerosis, and Hashimoto's thyroiditis, while it may promote inflammatory bowel disorders and type 1 diabetes mellitus. Read More

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http://dx.doi.org/10.1007/s13679-020-00397-8DOI Listing