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Arthritis care and research : the offic... Publications | PubFacts

318,047 results match your criteria Arthritis care and research : the official journal of the Arthritis Health Professions Association[Journal]


'Acute Flare-Ups' In Patients With, Or At High Risk Of, Knee Osteoarthritis: A Daily Diary Study With Case-Crossover Analysis.

Osteoarthritis Cartilage 2019 Apr 14. Epub 2019 Apr 14.

Clinical Epidemiology, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, UK. Electronic address:

Objective: To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures.

Design: Adults aged ≥45 years with a recent primary care consultation for knee OA/arthralgia completed a daily pen-and-paper diary for up to 3 months, including questions on average knee pain intensity, pain descriptors, other symptoms, activity interference, and selected physical exposures (prolonged kneeling, squatting, climbing stairs, ladders, and moving/lifting heavy objects). Informed by a systematic review, flare-ups were defined a priori. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.003DOI Listing

The γ Family of Cytokines: Basic Biology to Therapeutic Ramifications.

Immunity 2019 Apr;50(4):832-850

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Metabolic, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1674, USA. Electronic address:

The common cytokine receptor γ chain, γ, is a component of the receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ results in X-linked severe combined immunodeficiency in humans, and γ family cytokines collectively regulate development, proliferation, survival, and differentiation of immune cells. Here, we review the basic biology of these cytokines, highlighting mechanisms of signaling and gene regulation that have provided insights for immunodeficiency, autoimmunity, allergic diseases, and cancer. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.028DOI Listing

Targeting Interleukin-6 Signaling in Clinic.

Immunity 2019 Apr;50(4):1007-1023

Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita City, Osaka, Japan. Electronic address:

Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue injury, but excessive synthesis of IL-6 and dysregulation of IL-6 receptor signaling is involved in disease pathology. Therapeutic agents targeting the IL-6 axis are effective in rheumatoid arthritis, and applications are being extended to other settings of acute and chronic inflammation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193014
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http://dx.doi.org/10.1016/j.immuni.2019.03.026DOI Listing
April 2019
1 Read

Combined Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation to Model Inflammatory Lung Disease in Rheumatoid Arthritis.

J Bone Miner Res 2019 Apr 17. Epub 2019 Apr 17.

Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE.

Objectives: Rheumatoid Arthritis (RA) is characterized by extra-articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. The collagen-induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone/joint-lung inflammatory outcomes.

Methods: DBA/1J mice were intranasally treated with saline or ODE daily for 5 weeks. Read More

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http://dx.doi.org/10.1002/jbmr.3745DOI Listing

Gastro-esophageal reflux and serum biomarkers in systemic sclerosis-related interstitial lung disease.

Arthritis Rheumatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University.

Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis (SSc) accounting for every third SSc-related death (1). Patients with SSc-ILD have a variable clinical course and can present both with a relatively stable/slowly declining lung function or severe/rapidly progressive pulmonary fibrosis. Therefore, not all patients will require aggressive immunosuppression that can provide more harm than benefit in a proportion of cases. Read More

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http://dx.doi.org/10.1002/art.40909DOI Listing

Decoding Skin Involvement in Chronic Graft-vs-Host Disease.

Authors:
Edward W Cowen

JAMA Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jamadermatol.2019.0354DOI Listing

An anterior neurovascular interval approach to coronal shear fractures of the distal humerus: a prospective clinical study with short- to mid-term follow-up.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):355-360. Epub 2019 Apr 11.

Emergency Center of Trauma, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.

Object: To explore the treatment effect of the anterior medial neurovascular interval approach to coronal shear fractures of the distal humerus.

Methods: This prospective study included two female patients who were 30-64 years old, with a mean age of 47 years. Fractures were caused by falling from a bicycle. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.355DOI Listing
March 2019
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Female Sex and Longer Fusion Constructs Significantly Increase the Risk of Total Hip Arthroplasty Following Spinal Fusion.

J Bone Joint Surg Am 2019 Apr;101(8):675-681

Department of Orthopaedic Surgery, UC Davis Medical Center, Sacramento, California.

Background: Previous studies have noted the progression of arthritis due to increased forces in articular structures adjacent to a fused joint. It is unknown whether spinal fusion generates increased forces at the hip joint causing progression to arthritis leading to total hip arthroplasty (THA). We sought to determine (1) is there a relationship between spinal fusion and THA, (2) what are risk factors for subsequent THA, and (3) is there a time interval from spinal fusion to THA?

Methods: A large patient discharge dataset was utilized to evaluate all patients who underwent spinal fusion and subsequent THA in California from 2004 through 2013. Read More

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http://dx.doi.org/10.2106/JBJS.18.00667DOI Listing
April 2019
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Potential role of MRN-100, an iron-based compound, in upregulating production of cytokine IL-10 in human dendritic cells to promote an anti-inflammatory response in vitro.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419844932

4 Division of Basic and Clinical Immunology, University of California Irvine, Irvine, CA, USA.

The hydroferrate fluid MRN-100, an iron-based compound with potent antioxidant characteristics, was examined to identify its possible anti-inflammatory effects on human dendritic cells (DCs) in vitro. Human monocyte-derived DCs were treated with MRN-100 at two concentrations (50 and 100 μL/mL) for 24 h and then stimulated with or without lipopolysaccharides (LPS). The expression of DC maturation markers was assessed by flow cytometry and the production of cytokines was determined by enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.1177/2058738419844932DOI Listing

Multiplexed immunoassay approach to characterize antidrug antibody like specific reactivity.

Bioanalysis 2019 Apr 17. Epub 2019 Apr 17.

Pfizer, 1 Burtt Rd, Andover, MA 01810, USA.

Characterization of antidrug antibody (ADA) like reactivity has emerged as critical element of bioanalytical design and assessment of compound immunogenicity risk. Multiplex immunoassay was applied to detect and characterize ADA like reactivity using Photonic Ring Immunoassay platform (Genalyte). Specific binding to human IgE or human recombinant IL21-receptor-Fc fusion using exogenous reagents as surrogates for drug specific reactivity was investigated. Read More

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http://dx.doi.org/10.4155/bio-2018-0072DOI Listing

Silicon intake and plasma level and their relationships with systemic redox and inflammatory markers in rheumatoid arthritis patients.

Adv Clin Exp Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Food Science and Dietetics, Wroclaw Medical University, Poland.

Background: The nutritional significance of silicon for the human body is highlighted by a continually growing body of evidence. In conditions of excessive reactive oxygen species and upregulated immune response, silicon has been observed to provide benefits, but its role in redox and inflammatory status has not yet been examined in rheumatoid arthritis (RA).

Objectives: The aim of this study was to assess the relationship of silicon intake and plasma level to systemic indices of redox status and inflammation in patients with RA. Read More

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http://dx.doi.org/10.17219/acem/105380DOI Listing

Care quality for rheumatoid arthritis patients in Quebec.

Int J Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Division of Clinical Epidemiology, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

Aim: The aims of this study were to: (a) measure the proportion of CARTaGENE rheumatoid arthritis (RA) patients fulfilling pre-specified quality indicators (ie disease-modifying antirheumatic drug [DMARD] use, regular follow up, use of folate supplementation, use of vitamin D and calcium, exercise and smoking status); and (b) examine variation in DMARD use with respect to patient age, sex, education and income.

Methods: A cohort of RA patients was constructed based on the CARTaGENE survey and health administrative database. CARTaGENE is a large, established, population-based study which recruited 19 995 participants from four metropolitan regions in Quebec. Read More

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http://dx.doi.org/10.1111/1756-185X.13580DOI Listing

Development of a methotrexate educational guide/information/monitoring booklet for inflammatory arthritis.

Musculoskeletal Care 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology, University Hospital Waterford, Waterford, Ireland.

Introduction: There are over 40,000 people living in Ireland with inflammatory arthritis (IA), a condition that is potentially destructive in nature and can have personal, social and economic consequences. Although we have witnessed dramatic changes in the treatment of IA in the last two decades, methotrexate (MTX) remains the first-line treatment for patients with a diagnosis of IA. Despite the fact that MTX is so commonly prescribed, there is a lack of educational materials both for healthcare professionals (HCPs) and patients. Read More

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http://dx.doi.org/10.1002/msc.1398DOI Listing

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.

Commun Biol 2019 8;2:115. Epub 2019 Apr 8.

5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.

Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci (<5 × 10) including eight novel loci. Read More

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http://dx.doi.org/10.1038/s42003-019-0339-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453927PMC

Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases.

J Immunol Res 2019 12;2019:2160192. Epub 2019 Mar 12.

Department of Medicine, University of Wisconsin-Madison, 1685 Highland Avenue, Madison, WI 53705, USA.

In rheumatoid arthritis, an autoimmune inflammatory arthritis, citrullinated proteins are targeted by autoantibodies and thus thought to drive disease. Neutrophil extracellular traps (NETs) are a source of citrullinated proteins and are increased in rheumatoid arthritis and therefore also implicated in disease pathogenesis. However, not all NETs are citrullinated. Read More

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http://dx.doi.org/10.1155/2019/2160192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434303PMC

The assessment of instability in the osteoarthritic knee.

EFORT Open Rev 2019 Mar 8;4(3):70-76. Epub 2019 Mar 8.

Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK.

Patient-reported instability is a common complaint amongst those with knee arthritis.Much research has examined the assessment of self-reported instability in the knee; however, no definitive quantitative measure of instability has been developed.This review focuses on the current literature investigating the nature of self-reported instability in the arthritic knee and discusses the possibilities of further investigation. Read More

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http://dx.doi.org/10.1302/2058-5241.4.170079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440299PMC

Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial.

Ann Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Service of Infectious Diseases, Hopitaux Universitaires de Geneve, Geneva, Switzerland

Objective: The optimal duration of postsurgical antibiotic therapy for adult native joint bacterial arthritis remains unknown.

Methods: We conducted a prospective, unblinded, randomised, non-inferiority study comparing either 2 or 4 weeks of antibiotic therapy after surgical drainage of native joint bacterial arthritis in adults. Excluded were implant-related infections, episodes without surgical lavage and episodes with a follow-up of less than 2 months. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-215116DOI Listing

Real-life effectiveness of ustekinumab in inflammatory bowel disease patients with concomitant psoriasis or psoriatic arthritis: An IG-IBD study.

Dig Liver Dis 2019 Apr 13. Epub 2019 Apr 13.

IBD Unit, Presidio Columbus, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address:

Background: Few data exist regarding the effectiveness of ustekinumab in inflammatory bowel disease (IBD) patients treated for concomitant psoriasis or psoriatic arthritis.

Aims: to describe the outcomes of IBD patients who received subcutaneous ustekinumab through a dermatological or rheumatological prescription.

Methods: This multicenter, retrospective study included all IBD patients who were started on ustekinumab for concomitant active psoriasis/ psoriatic arthritis, irrespective of IBD activity. Read More

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http://dx.doi.org/10.1016/j.dld.2019.03.007DOI Listing

Obstetric outcomes in women with rheumatoid arthritis: Results from Nationwide Inpatient Sample Database 2003-2011.

Semin Arthritis Rheum 2019 Mar 23. Epub 2019 Mar 23.

University of Mississippi, 2500 North State Street, Jackson, MS 39232, United States.

Objective: Fertility is reduced in patients with Rheumatoid Arthritis due to unknown cause. Few studies have addressed pregnancy outcomes in RA. This study was undertaken to determine the frequency of complications occurring during pregnancy for women with RA and compare with the general obstetric population by using the largest inpatient care database. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.011DOI Listing

Correction to: Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a randomized, placebo-controlled phase III trial in Japan.

Arthritis Res Ther 2019 Apr 16;21(1):99. Epub 2019 Apr 16.

Division of Rheumatology, Department of Internal Medicine, School of Medicine, Toho University, 2-22-36 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan.

Following publication of the original article [1], the authors reported an error in Table 2. Read More

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http://dx.doi.org/10.1186/s13075-019-1887-xDOI Listing

How to Get the Most from Methotrexate (MTX) Treatment for Your Rheumatoid Arthritis Patient?-MTX in the Treat-to-Target Strategy.

J Clin Med 2019 Apr 15;8(4). Epub 2019 Apr 15.

Division of Rheumatology, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland.

Methotrexate (MTX) is a remarkable drug with a key role in the management of rheumatoid arthritis (RA) at every stage of its evolution. Its attributes include good overall efficacy for signs and symptoms, inhibition of structural damage and preservation of function with acceptable and manageable safety, a large dose-titratable range, options for either an oral or parenteral route of administration, and currently unrivalled cost-effectiveness. It has a place as a monotherapy and also as an anchor drug that can be safely used in combination with other conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or used concomitantly with biological DMARDs or targeted synthetic DMARDs. Read More

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http://dx.doi.org/10.3390/jcm8040515DOI Listing

Translational drug discovery and development with the use of tissue-relevant biomarkers: towards more physiological relevance and better prediction of clinical efficacy.

Exp Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Sanofi, Global Head of Immunology Therapeutic Research Area, 640 Memorial Drive, Cambridge, MA, 02139, USA.

Due to the clinical development of drugs such as secukinumab, ustekinumab and dupilumab, major changes have been achieved in the treatment of patients diagnosed with psoriasis and atopic dermatitis. In academia and the pharmaceutical industry, research is increasingly moving towards the development of bi-specific antibodies and multi-specific nanobodies, as there is a compelling need for new treatment modalities for patients suffering from auto-immune or malignant disease. The purpose of this review is to discuss aspects of translational drug development with a particular emphasis on indications such as psoriasis and atopic dermatitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13942
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http://dx.doi.org/10.1111/exd.13942DOI Listing
April 2019
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Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.

J Clin Invest 2019 Apr 16;130. Epub 2019 Apr 16.

The polarization of macrophages is regulated by transcription factors such as nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1). In this manuscript, we delineated the role of the transcription factor Fos-related antigen 1 (Fra-1) during macrophage activation and development of arthritis. Network level interaction analysis of microarray data derived from Fra-1- or Fra-2-deficient macrophages revealed a central role of Fra-1, but not of Fra-2 in orchestrating the expression of genes related to wound response, toll-like receptor activation and interleukin signaling. Read More

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http://dx.doi.org/10.1172/JCI96832DOI Listing

Mapping citrullinated sites in multiple organs of mice using hyper-citrullinated library.

J Proteome Res 2019 Apr 16. Epub 2019 Apr 16.

Protein citrullination (or deimination), irreversible post-translational modification, have been implicated in several physiological and pathological processes, including gene expression regulation, apoptosis, Rheumatoid arthritis, and Alzheimer's disease. Several researches have been carried out on citrullination in many conditions. However, until now, challenges in sample preparation and data analysis make it difficult to confidently identify a citrullinated protein and assign the citrullinated site. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00118DOI Listing
April 2019
2 Reads

Helios but not CD226, TIGIT and Foxp3 is a Potential Marker for CD4 Treg Cells in Patients with Rheumatoid Arthritis.

Cell Physiol Biochem 2019 ;52(5):1178-1192

Department of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, United States,

Background/aims: Rheumatoid arthritis (RA) is a progressive, chronic, even disabling systemic autoimmune disease. Imbalance between pathogenic immune cells and immunosuppressive cells is associated with the pathogenesis and development of RA and other autoimmune diseases. As Foxp3 is also expressed on activated CD4 cells in the presence of inflammation, the identification of Treg cells in patients with RA remains a challenge. Read More

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http://dx.doi.org/10.33594/000000080DOI Listing
January 2019

Automatic Hand Skeletal Shape Estimation from Radiographs.

IEEE Trans Nanobioscience 2019 Apr 12. Epub 2019 Apr 12.

Rheumatoid arthritis (RA) is an autoimmune disease whose common manifestation involves the slow destruction of joint tissue, damage that is visible in a radiograph. Over time, this damage causes pain and loss of functioning which depends, to some extent, on the spatial deformation induced by the joint damage. Building an accurate model of the current deformation and predicting potential future deformations is an important component of treatment planning. Read More

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http://dx.doi.org/10.1109/TNB.2019.2911026DOI Listing

Type of job, personal factors, and disease status are important contextual factors when measuring worker productivity in people with arthritis: a Delphi study.

Disabil Rehabil 2019 Apr 16:1-8. Epub 2019 Apr 16.

a Department of Rehabilitation and Movement Science , University of Vermont , Burlington , VT , USA.

Purpose: Arthritis is associated with lost wages, work disability, and decreased productivity. There is a lack of knowledge regarding contextual factors that influence worker productivity to inform rehabilitation. Our study aims to identify the essential contextual factors that need to be considered when measuring worker productivity outcomes in people with arthritis. Read More

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http://dx.doi.org/10.1080/09638288.2019.1597181DOI Listing

Aberrant expression of microRNAs in peripheral blood mononuclear cells as candidate biomarkers in patients with axial spondyloarthritis.

Int J Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objectives: Axial spondyloarthritis (axSpA) is a chronic inflammatory arthritis involving the axial skeleton. Recent evidence suggests that microRNAs (miRNAs) play a critical role in ankylosing spondylitis (AS). In this study, we aimed to investigate whether miR-17-5p, miR-27a, miR-29a and miR-126-3p can be verified as potential biomarkers of axSpA. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13
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http://dx.doi.org/10.1111/1756-185X.13563DOI Listing
April 2019
1 Read

[Mufangji Decoction formula tracing and its effect on emergency and severe cases].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):388-400

Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.

Mufangji Decoction is a famous herbal formula from Synopsis of Golden Chamber. However,it is easy to be misunderstood due to so its unique compatability. The syndromes treated by Mufangji Decoction included the following aspects:(1) in terms of modern medicine,it could be used to treat acute and chronic heart failure,heart failure aggravated by lung infection,chronic obstructive pulmonary disease acute episode,pulmonary heart disease,bilateral pleural effusion,acute attack of gout,rheumatic fever,rheumatoid arthritis,and rheumatoid arthritis;(2) in terms of symptoms,it could be used to treat asthma,chest tightness,wheeze impacting prostration and dyspnea impacting sitting posture; gastric distention; dark face,cyanotic,and mitral valvular face; edema of head and extremities; dry mouth,thirsty,unwilling to wear thick clothes,intolerance of heat,and irritable; fatigue,shortness of breath,poor appetite,constipation,less urine,yellow color,poor response to diuretics,and diuretic resistance; fast heart rate,which is hard to be controlled by Western medicine and has no response to Zhenwu Decoction; dark red tongue,dry tongue with yellow fur,rapid pulse,or deep tight pulse. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.2019.0009DOI Listing
January 2019

[Regularity of prescription and medication of Jiang Quan in treating rheumatoid arthritis].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):381-387

Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.

The data mining method was used to analyze and summarize the prescription and medicate regularities of chief physician Jiang Quan in the treatment of rheumatoid arthritis,in order to provide references for the clinical treatment of rheumatoid arthritis. Totally 121 prescriptions of rheumatoid arthritis treated by chief physician Jiang Quan from 2007 to 2017 were collected and input into the Chinese medicine inheritance auxiliary system. The " prescription statistics" function of the software " statistical report" system,and the " prescription analysis" function of the " data analysis" system,the data mining methods such as rule analysis,integration correlation,complex system entropy clustering,and unsupervised entropy hierarchical clustering,were used to analyze the prescription regularity of chief physician Jiang Quan. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181101.014DOI Listing
January 2019

[Pharmacokinetics of Achyranthes bidentata on adjuvant arthritis rats by microdialysis and UHPLC-MS/MS].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):364-371

Anhui University of Chinese Medicine Hefei 230012,China Key Laboratory of Xin'an Medicine,Ministry of Education Hefei 230038,China Anhui Province Key Laboratory of Chinese Herbal Compound Hefei 230012,China.

To investigate the " drug-guide" effect of Achyranthes bidentata saponins( ABS) and geniposide( GE) in the treatment on adjuvant arthritis( AA) rats. A UHPLC-MS/MS method for the quantitative determination of GE,zingibroside R1,ginsenoside Ro and chikusetsu saponin Ⅳa in rat blood and joint dialysate was established. After single or combined administration with ABS and GE was given to AA rat model,a microdialysis sampling method for rat joint cavity and jugular vein blood vessels was established to collect microdialysis samples. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181101.006DOI Listing
January 2019

[Effect of ethanolic extract of Polygonum cuspidatum on acute gouty arthritis in mice through NLRP3/ASC/caspase-1 axis].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(3):546-552

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.

The aim of this paper was to study the effect and mechanism of alcohol extract from Polygonum cuspidatum(PCE) on acute gouty arthritis in C57 BL/6 mice through NLRP3/ASC/caspase-1 axis. The model mice which injected with ankle joint injection of sodium urate crystals(MSU) were orally administrated with three different concentration of PCE, with colchicine as positive control. HE staining was used for observing the morphological changes of synovial tissue; concentration of IL-1β, IL-6 and TNF-α secreted by synovial tissue of the ankle joint were detected by ELISA; mRNA and protein expression of NLRP3, ASC and caspase-1 in synovial tissue were detected by RT-PCR and Western blot respectively. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20180925.
Publisher Site
http://dx.doi.org/10.19540/j.cnki.cjcmm.20180925.001DOI Listing
February 2019
1 Read

[Research progress of studies on chemical constituents and biologic activities of Anemone species].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(5):912-919

Key Laboratory of Bological Resources Protection and Utilization of Hubei Province Enshi 445000,China.

Anemone is an important genus which was distributed widely and used to folk medicines in China. It is rich of pentacyclic triterpenoid saponins,and more than 100 kinds of pentacyclic triterpenoid saponins had been isolated and identified. Anemone has been used to treat punch injury and rheumatoid arthritis. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181226.011DOI Listing

Value of serum procalcitonin for the diagnosis of bacterial septic arthritis in daily practice in rheumatology.

Clin Rheumatol 2019 Apr 16. Epub 2019 Apr 16.

CHRU Jean Minjoz, Service de Rhumatologie, 3 Boulevard Alexandre Fleming, 25000, Besancon, France.

Introduction/objectives: Septic arthritis is a diagnostic and therapeutic emergency because of a high morbidity and mortality. Nevertheless, the etiologic diagnosis is often difficult. The aim of our study was to determine if serum procalcitonin was a discriminatory biomarker in case of arthritis of undetermined etiology. Read More

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http://dx.doi.org/10.1007/s10067-019-04542-0DOI Listing

Discordance between doctor and patient assessments and non-adherence to subcutaneous biological drugs.

Rheumatol Int 2019 Apr 16. Epub 2019 Apr 16.

Medical Affairs, Merck Sharp & Dohme S.A, Madrid, Spain.

To estimate the agreement level between patient and physician assessment of disease activity and to explore whether agreement is associated with adherence to subcutaneous (SC) biological drugs in rheumatoid arthritis (RA). Cross-sectional study of RA patients who had been prescribed a SC biological drug in the past 12-18 months was performed. Patients and physicians global disease activity on visual analogue scale (VAS) were collected. Read More

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http://dx.doi.org/10.1007/s00296-019-04304-wDOI Listing

Highly variable coronal tibial and femoral alignment in osteoarthritic knees: a systematic review.

Knee Surg Sports Traumatol Arthrosc 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthopaedic Surgery and Traumatology, Kantonsspital Baselland (Bruderholz, Liestal, Laufen), 4101, Bruderholz, Switzerland.

Purpose: There is a lack of knowledge about coronal alignment variability in osteoarthritic knees. Therefore, the purpose of this article was to systematically review the literature and collect data about the lower limb alignment including hip-knee-ankle angle (HKA), femoral mechanical angle (FMA), tibial mechanical angle (TMA) and the joint line convergence angle (JLCA) in osteoarthritic knees.

Methods: A systematic review was performed using the electronic databases MEDLINE (PubMed), EMBASE and Google Scholar. Read More

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http://dx.doi.org/10.1007/s00167-019-05506-2DOI Listing

Upper extremity myxofibrosarcoma mimicking an erosive inflammatory arthritis: a case report.

Skeletal Radiol 2019 Apr 15. Epub 2019 Apr 15.

Imaging Institute, Cleveland Clinic, 9500 Euclid Ave. A21, Cleveland, OH, 44195, USA.

Myxofibrosarcoma is a malignant fibroblastic soft tissue neoplasm containing a variable amount of myxoid stroma that commonly presents as a slow-growing mass in elderly patients. The neoplasm may be superficial or deep to the muscle fascia and characteristically has an infiltrative growth pattern with a dominant or multinodular mass. We describe an unusual case of high-grade myxofibrosarcoma of the wrist and forearm that infiltrated the muscles, tendons, and wrist joint, causing bone erosions. Read More

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http://link.springer.com/10.1007/s00256-019-03217-w
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http://dx.doi.org/10.1007/s00256-019-03217-wDOI Listing
April 2019
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Supercapsular percutaneously assisted (SuperPath) approach in total hip arthroplasty : Surgical technique and preliminary results.

Authors:
H Quitmann

Oper Orthop Traumatol 2019 Apr 12. Epub 2019 Apr 12.

Fabricius Klinik, Gelenkzentrum Bergisch Land, Freiheitstsr. 203, 42853, Remscheid, Germany.

Objective: Portal assisted minimally invasive total hip arthroplasty without dislocation of the femoral head with preservation of the hip capsule and the external rotators in the lateral decubitus position for rapid recovery with the option of expandability to a mini posterior or classic posterolateral approach at any time.

Indications: Primary and secondary arthritis of the hip, femoral head necrosis, femoral neck fracture.

Contraindications: Severe anatomical disorders of the proximal femur, congenital high hip dysplasia, implanted hardware in the trochanteric region, local and systemic infections. Read More

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http://dx.doi.org/10.1007/s00064-019-0597-5DOI Listing

Characterization of Blau syndrome panuveitis with wide-field fluorescein angiography.

Am J Ophthalmol Case Rep 2019 Jun 29;14:92-94. Epub 2019 Mar 29.

Department of Ophthalmology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose: To describe a case of Blau panuveitis, characterized on both portable and tabletop wide-field fluorescein angiography, which resolved on systemic immunosuppression.

Observations: A 5-year-old female presented with bilateral eye pain, redness, and decreased visual acuity due to panuveitis and had a history of arthritis, tenosynovitis, and dermatitis. Similar ocular and systemic findings in the patient's mother and maternal half-brother prompted genetic testing that confirmed the diagnosis of the rare Blau syndrome. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447728PMC

Serological Diagnosis of Lentivirus Infection in Goats Raised in Algeria.

J Vet Res 2019 Mar 22;63(1):27-33. Epub 2019 Mar 22.

INRA/UGA USC 1450, Pathogenesis and Lentivirus Vaccination Laboratory, PAVAL Lab., Université Grenoble Alpes, 38041, Grenoble Cedex 9, France.

Introduction: Infection of goats with caprine arthritis encephalitis virus (CAEV) has been detected in variable proportions in many countries all over the world. Here, we investigated the seroprevalence of CAEV in goats raised in Algeria.

Material And Methods: A serological survey was performed on serum samples from 1,313 goats, including the local breeds (Arabia and Dwarf of Kabylia) and imported European breeds (Alpine and Saanen). Read More

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http://dx.doi.org/10.2478/jvetres-2019-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458564PMC

Au Clusters Treat Rheumatoid Arthritis with Uniquely Reversing Cartilage/Bone Destruction.

Adv Sci (Weinh) 2019 Apr 15;6(7):1801671. Epub 2019 Feb 15.

CAS Key Laboratory for the Biological Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China.

Super-small nanoclusters may intrinsically trigger specific molecular pathway for disease treatment in vitro/vivo. To prove the hypothesis the super-small nanoclusters, e.g. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.2018016
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http://dx.doi.org/10.1002/advs.201801671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446600PMC
April 2019
1 Read

Osteosarcoma of the Proximal Femur Mimicking Septic Arthritis of the Hip: A diagnostic dilemma.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e545-e548. Epub 2019 Mar 28.

Department of Orthopaedics, Armed Forces Hospital, Salalah, Oman.

Septic arthritis is a surgical emergency requiring prompt drainage of the accumulation of pus in the joint. We report an eight-year-old boy who was referred to the Armed Forces Hospital, Salalah, Oman, in 2016 with limping and pain in his right hip along with an abduction deformity. He was initially diagnosed with synovitis and underwent conservative management. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443267PMC
November 2018

Aspects of exercise with person-centred guidance influencing the transition to independent exercise: a qualitative interview study among older adults with rheumatoid arthritis.

Eur Rev Aging Phys Act 2019 5;16. Epub 2019 Apr 5.

1Department of Health and Rehabilitation, Unit of Physiotherapy, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Box 455, 405 30 Göteborg, Gothenburg, Sweden.

Background: Besides being health enhancing and disease preventing, exercise is also an important part of the management of chronic conditions, including the inflammatory joint disease rheumatoid arthritis (RA). However, older adults with RA present a lower level of physical activity than healthy older adults. The aim of this qualitative study was to explore aspects of participation in moderate- to high-intensity exercise with person-centred guidance influencing the transition to independent exercise for older adults with RA. Read More

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http://dx.doi.org/10.1186/s11556-019-0211-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449916PMC

Comparison of efficacy and complications between two types of staging arthroplasty in treating chronic septic hip arthritis: A retrospective clinical study.

Exp Ther Med 2019 May 22;17(5):4123-4131. Epub 2019 Mar 22.

Department of Orthopedic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China.

Septic hip arthritis is a rare but serious disease, which is often persistent, able to transform into a chronic infection, and difficult to cure. The present study aimed to compare the midterm outcomes between the staging of a total hip arthroplasty via the Girdlestone surgery (a resection of the head and neck) and the Girdlestone combined with a cement spacer in treating chronic septic hip arthritis, as well as to compare the postsurgery efficacy and complications between the two groups. A total of 13 patients (14 total hip joints) were enrolled and retrospectively analyzed. Read More

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http://dx.doi.org/10.3892/etm.2019.7430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447925PMC

Investigation of gene expression profiles in a rat adjuvant arthritis model suggests an effective role of triptolide via PI3K-AKT signaling.

Authors:
Yang Zou Weifeng Hu

Exp Ther Med 2019 May 20;17(5):3999-4006. Epub 2019 Mar 20.

Department of Orthopedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310005, P.R. China.

Rheumatoid arthritis (RA) is a common systemic autoimmune disease mainly involving the formation of a synovial pannus, for which no effective treatment is available. In order to study the molecular biological mechanisms underlying the inhibition of RA synovial pannus by triptolide, differentially expressed genes in synovial tissues from an adjuvant arthritis (AA) rat model with and without triptolide treatment were detected in an mRNA microarray profile produced by Agilent Technologies and verified by reverse transcription-quantitative polymerase chain reaction analysis (RT-qPCR). An AA model was established by subcutaneously injecting 0. Read More

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http://dx.doi.org/10.3892/etm.2019.7425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447910PMC

Inhibitory effect of tanshinone IIA on inflammatory response in rheumatoid arthritis through regulating β-arrestin 2.

Exp Ther Med 2019 May 12;17(5):3299-3306. Epub 2019 Mar 12.

Department of Emergency, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310005, P.R. China.

The current study aimed to investigate the inhibitory effect of tanshinone IIA (Tan IIA) on the inflammatory response in patients with rheumatoid arthritis (RA) and explore its mechanism. A total of 50 patients with RA were randomly separated into the control group (15 cases) and the research group (35 cases). The tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels in serum were determined, and peripheral blood mononuclear cells (PBMCs) were separated from patients with RA and cultured . Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7371
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http://dx.doi.org/10.3892/etm.2019.7371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447808PMC
May 2019
1 Read

Shikonin Prolongs Allograft Survival via Induction of CD4FoxP3 Regulatory T Cells.

Front Immunol 2019 1;10:652. Epub 2019 Apr 1.

Section of Immunology, The Second Clinical Medical College of Guangzhou University of Chinese Medicine, and Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.

A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tumors, and infections. Therefore, it is necessary to seek novel immunosuppressive agents, especially natural ingredients that may provide sufficient efficacy in immunosuppression with minimal side effects. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00652
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http://dx.doi.org/10.3389/fimmu.2019.00652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451963PMC
April 2019
1 Read

Anti-IL-10 antibody in systemic lupus erythematosus.

Open Access Rheumatol 2019 26;11:61-65. Epub 2019 Mar 26.

Division of Rheumatology and Allergology, St. Marianna University School of Medicine, Kawasaki City, Kanagawa, Japan,

Purpose: IL-10 is a cytokine known to inhibit inflammatory cytokines. To determine its role in the pathogenesis of systemic lupus erythematosus (SLE), the presence of anti-IL-10 antibody is required to be examined. Although antibodies against cytokines are known to be present in SLE, no studies have determined the role of IL-10, particularly in Japanese patients. Read More

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http://dx.doi.org/10.2147/OARRR.S191953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440452PMC

Conversion to total hip arthroplasty in posttraumatic arthritis: short-term clinical outcomes.

Orthop Res Rev 2019 4;11:41-46. Epub 2019 Feb 4.

Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran,

Background: Fractures of the acetabulum are challenging and very difficult to treat, and even after fixation, they can lead to posttraumatic arthritis. Total hip arthroplasty (THA) has been the most common surgery performed for the complications of posttraumatic arthritis in this group of patients.

Aim: In this article, it is aimed to assess the functional results and complications of the conversion to THA for posttraumatic arthritis after acetabular fracture. Read More

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http://dx.doi.org/10.2147/ORR.S184590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442317PMC
February 2019

Repeat domain-associated O-glycans govern PMEL fibrillar sheet architecture.

Sci Rep 2019 Apr 15;9(1):6101. Epub 2019 Apr 15.

Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06519, USA.

PMEL is a pigment cell-specific protein that forms a functional amyloid matrix in melanosomes. The matrix consists of well-separated fibrillar sheets on which the pigment melanin is deposited. Using electron tomography, we demonstrate that this sheet architecture is governed by the PMEL repeat (RPT) domain, which associates with the amyloid as an accessory proteolytic fragment. Read More

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http://dx.doi.org/10.1038/s41598-019-42571-6DOI Listing