26,966 results match your criteria Arthritis care & research[Journal]


Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.

J Am Geriatr Soc 2020 Jul 7. Epub 2020 Jul 7.

Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Objectives: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht ); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality). Read More

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http://dx.doi.org/10.1111/jgs.16517DOI Listing

Trends and outcomes of fungal infections in hospitalized patients of inflammatory bowel disease: a nationwide analysis.

Transl Gastroenterol Hepatol 2020 5;5:35. Epub 2020 Jul 5.

Department of Gastroenterology & Hepatology, University of Toledo Medical Center, Toledo, OH, USA.

Background: Immunosuppressive therapy is being increasingly used in the management of inflammatory bowel disease (IBD) which comprises of ulcerative colitis (UC) and Crohn's disease (CD). Patients on immunosuppressive therapy are at increased risk of developing opportunistic fungal infections. We conducted this analysis to describe the epidemiology of opportunistic fungal infections in this cohort. Read More

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http://dx.doi.org/10.21037/tgh.2019.10.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063509PMC

A systematic review and evidence synthesis of non-medical triage, self-referral and direct access services for patients with musculoskeletal pain.

PLoS One 2020 6;15(7):e0235364. Epub 2020 Jul 6.

Arthritis Research UK Primary Care Centre, School of Primary, Community & Social Care, Keele University, Keele, United Kingdom.

Introduction: The demand for musculoskeletal (MSK) care is rising, and is a growing challenge for general practice. Direct access to physiotherapy and other healthcare services may offer appropriate care for MSK pain patients but there is uncertainty regarding the effectiveness or efficiency of this approach in practice. This study aimed to review the evidence regarding characteristics, outcomes, barriers and facilitators of MSK triage and direct access services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235364PLOS

Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis.

Arthritis Care Res (Hoboken) 2020 Jul 5. Epub 2020 Jul 5.

Department of Rheumatology, the third Affiliated Hospital of SUN YAT-SEN University, Guangzhou, China.

Objectives: This study aims to determine whether vitamin D supplementation or maintaining sufficient vitamin D level reduces foot pain over two years in patients with symptomatic knee OA.

Methods: A post hoc study was conducted from a randomized double-blind placebo-controlled trial named the VItamin D Effect on Osteoarthritis (VIDEO) study. Symptomatic knee OA patients with serum 25-hydroxyvitamin D levels between 12. Read More

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http://dx.doi.org/10.1002/acr.24371DOI Listing

Do rheumatoid arthritis patients have low back pain or radiological lumbar lesions more frequently than the healthy population? -Cross-sectional analysis in a cohort study with age and sex-matched healthy volunteers.

Spine J 2020 Jul 2. Epub 2020 Jul 2.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background Context: Rheumatoid arthritis (RA) can affect the spine; however, the epidemiology of lumbar lesions and/or low back pain (LBP) in RA patients has not been well-studied.

Purpose: The purpose of this study was to compare the prevalence of lumbar lesions and LBP in RA patients with that in healthy volunteers, and to elucidate the influence of RA on lumbar disease.

Study Design: Cross-sectional analysis in a cohort study with age- and sex-matched healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.06.020DOI Listing

Autoantibodies to Malondialdehyde-Acetaldehyde Are Detected Prior to Rheumatoid Arthritis Diagnosis and After Other Disease Specific Autoantibodies.

Arthritis Rheumatol 2020 Jul 4. Epub 2020 Jul 4.

Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA.

Objectives: To examine serum autoantibodies to malondialdehyde-acetaldehyde (MAA) prior to rheumatoid arthritis (RA) diagnosis.

Methods: Anti-MAA antibody isotypes, anti-CCP2, and RF-IgM were measured in pre- and post-RA diagnosis samples (n=214 cases, 210 controls). The timing of elevations in autoantibody concentrations relative to RA diagnosis was explored using separate mixed-models for each antibody and/or isotype. Read More

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http://dx.doi.org/10.1002/art.41424DOI Listing

Extensor tendon ruptures in rheumatoid wrists.

Eur J Orthop Surg Traumatol 2020 Jul 3. Epub 2020 Jul 3.

Klinik Und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie-Operative Notaufnahme, UKGM Universitätsklinikum Gießen Und Marburg, Rudolf-Buchheim-Str. 7, 35392, Giessen, Germany.

Background And Aims: Rheumatoid arthritis is a chronic inflammatory disease. The associated involvement of hands and tendons is over 90% and impairs overall function. In the course of the disease, the joints are often operated on. Read More

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http://dx.doi.org/10.1007/s00590-020-02731-1DOI Listing

Understanding factors associated with vaccine uptake and vaccine hesitancy in patients with rheumatoid arthritis: a scoping literature review.

Clin Rheumatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Psychology, Université du Québec à Montréal (UQAM), CP 8888, Sucursale Centre-Ville, Montréal, Quebec, H3C 3P8, Canada.

Due to higher risk of complications associated with vaccine-preventable infections (e.g., influenza, pneumococcus), patients with rheumatoid arthritis (RA) are a priority group for vaccination. Read More

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http://dx.doi.org/10.1007/s10067-020-05059-7DOI Listing

Changing the outcome measures, changing the results? The urgent need of a specific disease activity score to adult-onset Still's disease.

Ann Rheum Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Clinical Sciences and Applied Biotechnology, University of L'Aquila, L'Aquila, Abruzzo, Italy

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http://dx.doi.org/10.1136/annrheumdis-2020-218032DOI Listing

Response to: 'Changing the outcome measures, changing the results? The urgent need of a specific Disease Activity Score to adult-onset Still's disease' by Ruscitti .

Ann Rheum Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2020-218143DOI Listing

Therapeutic approaches in the treatment of gout.

Semin Arthritis Rheum 2020 Jun;50(3S):S24-S30

Rheumatic and Immunologic Diseases, The Cleveland Clinic, Cleveland, OH, United States.

Gout is a disease in which the metabolic condition hyperuricemia leads to the formation of monosodium urate crystals, which provoke acute and chronic inflammatory responses through activation of the innate immune system. Recent advances in our knowledge of gout pathogenesis have emphasized the role of the kidneys in urate handling, the evolutionary loss of uricase as a necessary precondition for hyperuricemia, and the central role of IL-1ß in the pathogenesis of gouty inflammation. These, and other advances, have shaped our current strategies for managing gout. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.04.010DOI Listing

Population-based estimates of healthy working life expectancy in England at age 50 years: analysis of data from the English Longitudinal Study of Ageing.

Lancet Public Health 2020 Jul;5(7):e395-e403

School of Primary, Community and Social Care, Keele University, Newcastle under Lyme, UK; MRC Versus Arthritis Centre for Musculoskeletal Health and Work, University of Southampton, Southampton, UK.

Background: Retirement ages are rising in many countries to offset the challenges of population ageing, but people's capacity to work for more years in their later working life (>50 years) is unclear. We aimed to estimate healthy working life expectancy in England.

Methods: This analysis included adults aged 50 years and older from six waves (2002-13) of the English Longitudinal Study of Ageing (ELSA), with linked mortality data. Read More

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http://dx.doi.org/10.1016/S2468-2667(20)30114-6DOI Listing

A Systematic Literature Review of Residual Symptoms and Unmet Need in Patients with Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2020 Jul 3. Epub 2020 Jul 3.

Botnar Research Centre, University of Oxford, Oxford, OX3 7LD, UK.

Objective: To evaluate the nature and burden of residual disease in rheumatoid arthritis (RA) in patients who meet treatment targets. Secondly, for those who did not meet targets, evaluate how much is due to patient symptoms.

Methods: Prospective and retrospective studies were searched in MEDLINE, Embase, and Cochrane Library in the English language from January 1, 2008, to April 18, 2018; conference abstracts (from January 2016 to April 2018) and reference lists of relevant studies were also screened. Read More

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http://dx.doi.org/10.1002/acr.24369DOI Listing

Associations between Smoking and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses.

Arthritis Care Res (Hoboken) 2020 Jul 3. Epub 2020 Jul 3.

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Background: Smoking has been associated with increased systemic lupus erythematosus (SLE) risk, but the biologic basis for this association is unknown. We investigated whether women's smoking was positively associated with SLE-associated pro-inflammatory chemokines/cytokines, [stem cell factor (SCF), B-lymphocyte stimulator (BLyS), interferon-inducible protein-10 (IP-10), interferon-alpha (IFN-α)]; or negatively associated with anti-inflammatory cytokine interleukin-10 (IL-10)]; and whether associations were modified by SLE-related autoantibody status.

Methods: The Nurses' Health Study (NHS, n=121,700) and NHSII (n=116,429) cohorts were begun in 1976 and 1989. Read More

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http://dx.doi.org/10.1002/acr.24370DOI Listing

Implant-safe test in patients with peri-implantitis.

J Biol Regul Homeost Agents 2020 May-Jun;34(3 Suppl. 1):147-153

Department of Life, Health and Environmental Sciences, University of L'Aquila.

Matrix metalloproteases (MMPs) are a family of zinc-dependent endopeptidases, produced by numerous cell types including fibroblasts, endothelial cells, osteoblasts, macrophages, lymphocytes and neutrophils, and capable of degrading different components of the extracellular matrix (ECM), but also cytokines, receptors and factors that regulate cell motility (1). MMPs represent the main proteolytic enzymes involved in the remodeling and degradation of the components of the extracellular matrix, in the modifications of interactions between cells, and those between cells and the ECM that regulate, for example, the processes of cell migration (2, 3). Due to these characteristics, the MMPs are involved in numerous physiological processes (angiogenesis, apoptosis, bone remodeling, wound repair, morphogenesis, inflammation, immune response) response to incongruous conservative and endodontic treatments (29-37, 46, 47) and pathological (periodontitis, arthritis, cancer, cardiovascular diseases, neurological diseases, osteoporosis etc. Read More

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Stratified care versus usual care for management of patients presenting with sciatica in primary care (SCOPiC): a randomised controlled trial.

Lancet Rheumatol 2020 Jul 25;2(7):e401-e411. Epub 2020 Jun 25.

Primary Care Centre Versus Arthritis, School of Primary, Community and Social Care, Keele University, Keele, UK.

Background: Sciatica has a substantial impact on individuals and society. Stratified care has been shown to lead to better outcomes among patients with non-specific low back pain, but it has not been tested for sciatica. We aimed to investigate the clinical and cost-effectiveness of stratified care versus non-stratified usual care for patients presenting with sciatica in primary care. Read More

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http://dx.doi.org/10.1016/S2665-9913(20)30099-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323615PMC

Comparison of readmission and early revision rates as a quality metric in total knee arthroplasty using the Nationwide Readmission Database.

Ann Transl Med 2020 Jun;8(11):687

Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA.

Background: After release of the Comprehensive Care for Joint Replacement bundle, there has been increased emphasis on reducing readmission rates for total knee arthroplasty (TKA). The potential for a separate, clinically-relevant metric, TKA revision rates within a year following surgery, has not been fully explored. Based on this, we compared rates and payments for TKA readmission and revision procedures as metrics for improving quality and cost. Read More

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http://dx.doi.org/10.21037/atm-19-3463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327322PMC

Response to: 'Cutaneous adverse events with febuxostat after previous reactions to allopurinol: comment on the artcile by Singh and Clevland' by Quills .

Ann Rheum Dis 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

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http://dx.doi.org/10.1136/annrheumdis-2020-218263DOI Listing

Is there an association between long-term antibiotics for acne and subsequent infection sequelae and antimicrobial resistance? A systematic review protocol.

BMJ Open 2020 Jul 2;10(7):e033662. Epub 2020 Jul 2.

Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine Faculty of Epidemiology and Population Health, London, UK.

Introduction: Antimicrobial resistance (AMR) is a global health emergency. Acne vulgaris is a highly prevalent condition and the dominant role antibiotics play in its treatment is a major concern. Antibiotics are widely used in the treatment of acne predominantly for their anti-inflammatory effect, hence their use in acne may not be optimal. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033662DOI Listing

Short-Term Surgical Missions: Role of Pharmacist Volunteers.

J Pharm Pract 2020 Jul 2:897190020934296. Epub 2020 Jul 2.

Center for Healthcare Delivery Sciences, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, USA.

Health care professionals often participate in short-term surgical missions in underserved areas of the world. Surgical missions often rely on the use of medications to provide health care to these underserved areas in patients with multiple comorbid conditions. The direct role a pharmacist may have in surgical missions is not well described in the literature; however, numerous opportunities exist for pharmacist involvement to improve patient care and operational processes throughout medication planning and delivery of surgical missions. Read More

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http://dx.doi.org/10.1177/0897190020934296DOI Listing

Elevating the role of carers in rheumatoid arthritis management in the Asia-Pacific region.

Int J Rheum Dis 2020 Jul 1. Epub 2020 Jul 1.

Johnson & Johnson Pte Ltd, Singapore, Singapore.

Aim: Carers may offer valuable insight into the true health status of patients with rheumatoid arthritis (RA). This multinational, multi-stakeholder, exploratory study in Australia, China and Japan aimed to enrich our understanding of the role and potential impact of carers on RA management.

Method: This study used a 2-phase sequential mixed methods approach involving 3 key stakeholder groups: rheumatologists, RA patients and carers. Read More

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http://dx.doi.org/10.1111/1756-185X.13893DOI Listing
July 2020
1.771 Impact Factor

The impact of gender on the clinical presentation, management, and surgical outcomes of patients with native-joint septic arthritis.

J Eval Clin Pract 2020 Jul 1. Epub 2020 Jul 1.

Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

Rationale, Aims And Objectives: Approximately 20 000 cases of septic arthritis (SA) occur in the U.S. yearly. Read More

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http://dx.doi.org/10.1111/jep.13437DOI Listing
July 2020
1.580 Impact Factor

Patient-Initiated Follow-Up (PIFU) as reorganized support for increased patient involvement - focus group discussions among patients' with inflammatory arthritis.

BMC Rheumatol 2020 30;4:44. Epub 2020 Jun 30.

Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.

Background: Inflammatory Arthritis is characterized by lifelong medical treatment and an unpredictable trajectory because of the fluctuating nature of the diseases. Proactive disease management is recommended, which includes close monitoring of disease activity that traditionally has been ensured by outpatient visits to rheumatologists at various fixed intervals. Internationally, there is a growing interest in how healthcare systems can be more flexible, individual-oriented and increasingly involve patients with lifelong diseases in their own treatment and care. Read More

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http://dx.doi.org/10.1186/s41927-020-00143-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325086PMC

Nobody says to you "come back in six months and we'll see how you're doing": a qualitative interview study exploring young adults' experiences of sport-related knee injury.

BMC Musculoskelet Disord 2020 Jul 1;21(1):419. Epub 2020 Jul 1.

University of Bath, Claverton Down, Bath, BA2 7AY, UK.

Background: Regular exercise is vital for overall health, and key to the maintenance of joint health. However, whilst people are encouraged to participate in sport and exercise, many are unaware that they could be at risk of developing post-traumatic osteoarthritis (PTOA) in the years following sport-related injury. Younger adults (< 40 years) with PTOA can experience declining quality of life, comorbid health conditions, and symptoms that place a chronic burden on health services. Read More

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http://dx.doi.org/10.1186/s12891-020-03428-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329431PMC

Use of physiotherapy in patients with osteoarthritis in Germany- an analysis of a linkage of claims and survey data (from the PROCLAIR project).

Arthritis Care Res (Hoboken) 2020 Jul 1. Epub 2020 Jul 1.

Department of Health Services Research, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Objective: To examine utilization of physiotherapy (PT) and predictors for its use in individuals with osteoarthritis (OA) focusing on sociodemographic and disease-related factors.

Methods: For this cross-sectional study 657,807 persons (30-79 years) diagnosed with hip, knee or polyarticular OA were identified in claims data. In 2016 a questionnaire including information on disease status, demography and socioeconomics was sent to a random sample of 8,995 patients, stratified by sex, age and type of diagnosis. Read More

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http://dx.doi.org/10.1002/acr.24365DOI Listing

[Bronchiectasis - a review].

Laeknabladid 2020 Jul;106(7):352-361

Department of Radiology Karolinska University Hospital Stockholm, Sweden.

Bronchiectasis is a disease that is characterized by permanent bronchial dilation. This can be localized or diffuse in the lungs. The disease can occur at any age and causes cough, sputum production and repeated infections. Read More

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http://dx.doi.org/10.17992/lbl.2020.0708.592DOI Listing

Treatment Pattern Analysis and Health-care Resource Consumption on Patients with Psoriatic Arthritis or Ankylosing Spondylitis Treated with Biological Drugs in a Northern Italian Region.

Ther Clin Risk Manag 2020 9;16:509-521. Epub 2020 Jun 9.

CliCon S.r.l. Health, Economics & Outcomes Research, Ravenna, Italy.

Purpose: To analyze the treatment patterns of psoriatic arthritis (PSA) or ankylosing spondylitis (AS) patients under biological therapies and to evaluate in this population the health-care resource consumption and related costs.

Patients And Methods: A retrospective analysis was performed on administrative databases of the Veneto region. Patients ≥18 years with at least one prescription of biological drugs and a diagnosis at any level for PSA or AS from January 1, 2011 to December 31, 2016 (inclusion period) were included. Read More

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http://dx.doi.org/10.2147/TCRM.S248390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293402PMC

Population characteristics as important contextual factors in rheumatological trials: an exploratory meta-epidemiological study from an OMERACT Working Group.

Ann Rheum Dis 2020 Jun 30. Epub 2020 Jun 30.

Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

Objectives: To explore whether trial population characteristics modify treatment responses across various interventions, comparators and rheumatic conditions.

Methods: In this meta-epidemiological study, we included trials from systematic reviews available from the Cochrane Musculoskeletal Group published up to 23 April 2019 in Cochrane Library with meta-analyses of five or more randomised controlled trials (RCTs) published from year 2000. From trial reports, we extracted data on 20 population characteristics. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217237DOI Listing

Individualised placement support as an employment intervention for individuals with chronic pain: a qualitative exploration of stakeholder views.

BJGP Open 2020 Jun 30. Epub 2020 Jun 30.

Medical Research Council Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, UK.

Background: Individualised Placement and Support (IPS) is a tailored, client-centred employment intervention for people with chronic health conditions. It involves the integration of vocational advisers within health teams to optimise return-to-work strategies. The intervention aims to get clients into employment by complementing traditional job searching skills with placements, and one-to-one mentoring alongside a work-focused health intervention. Read More

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http://dx.doi.org/10.3399/bjgpopen20X101036DOI Listing

Necrobiosis Lipoidica in a Patient with β-Thalassemia Major: A Case Report and Review of the Literature.

Hemoglobin 2020 Jul 1:1-3. Epub 2020 Jul 1.

Adult Thalassemia Unit, Second Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Necrobiosis lipoidica (NL) is a rare granulomatous disease that predominantly affects middle-aged women and is often associated with diabetes mellitus (DM), rheumatoid arthritis (RA) and other metabolic disorders. Thalassemias are the most common hereditary hemoglobin (Hb) disorders worldwide. A few studies investigated dermatologic problems that coexist with β-thalassemia major (β-TM). Read More

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http://dx.doi.org/10.1080/03630269.2020.1783287DOI Listing

Rheumatoid Arthritis: Pathogenesis, Prediction and Prevention - An Emerging Paradigm Shift.

Arthritis Rheumatol 2020 Jun 30. Epub 2020 Jun 30.

Division of Rheumatology, University of Colorado Denver School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.

Rheumatoid arthritis (RA) is currently diagnosed and treated when an individual presents to health care with signs and symptoms of inflammatory arthritis (IA) as well as other features such as autoantibodies and/or imaging findings that provide sufficient confidence that the individual has RA-like IA (e.g. meeting established classification criteria) that warrants therapy. Read More

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http://dx.doi.org/10.1002/art.41417DOI Listing

Bioactive Plasma Mitochondrial DNA is Associated with Disease Progression in Scleroderma Associated Interstitial Lung Disease.

Arthritis Rheumatol 2020 Jun 30. Epub 2020 Jun 30.

Yale University School of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, USA.

Objective: SSc-ILD is characterized by variable clinical outcomes, activation of innate immune pattern recognition receptors (PRRs), and accumulation of αSMA expressing myofibroblasts. The association of these entities with mitochondrial DNA (mtDNA), an endogenous ligand for the intracellular DNA-sensing PRRs TLR9 and cGAS-STING, has yet to be determined.

Methods: Human lung fibroblasts from normal donors (NHLFs) and SSc-ILD explants were treated with synthetic CpG DNA and assayed for αSMA expression and extracellular mtDNA using qPCR for the human MT-ATP6 gene. Read More

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http://dx.doi.org/10.1002/art.41418DOI Listing

Brief Report: Anti-phospholipid antibodies in critically ill patients with Coronavirus Disease 2019 (COVID-19).

Arthritis Rheumatol 2020 Jun 30. Epub 2020 Jun 30.

Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730.

Objectives: Coagulopathy is one of the characteristics of critically ill patients with Coronavirus Disease 2019 (COVID-19). Antiphospholipid antibodies (aPLs) contribute to coagulopathy, but their role in COVID-19 remains unclear. We aimed to determine the prevalence and characteristics of aPLs in patients with COVID-19. Read More

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http://dx.doi.org/10.1002/art.41425DOI Listing

«Living with Rheumatoid Arthritis» in an Indigenous Qom Population in Argentina. A Qualitative Study.

Reumatol Clin 2020 Jun 26. Epub 2020 Jun 26.

Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.

Introduction: Rheumatoid arthritis (RA) is a chronic disease which impacts patients' quality of life. The prevalence of RA in the qom population was 2.4% and represented an aggressive and disabling disease. Read More

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http://dx.doi.org/10.1016/j.reuma.2020.04.016DOI Listing

Total Ankle Arthroplasty Survivorship: A Meta-analysis.

J Foot Ankle Surg 2020 Jun 26. Epub 2020 Jun 26.

Assistant Professor in Surgery, Department of Surgery, Harvard Medical School, Boston, MA; Chief, Division of Podiatric Surgery, Department of Surgery, Mount Auburn Hospital, Cambridge, MA.

The gold standard for management of end-stage ankle arthritis was previously ankle arthrodesis; however, improvements in total ankle replacements are making this a more viable treatment option. The primary aim of this meta-analysis was to evaluate the survivorship of total ankle replacement implants currently in use. An extensive search strategy initially captured 20,842 citations that were evaluated for relevance. Read More

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http://dx.doi.org/10.1053/j.jfas.2019.10.011DOI Listing

Autoimmune rheumatic diseases and premature atherosclerotic cardiovascular disease: An analysis from the VITAL (Veterans wIth premaTure AtheroscLerosis) registry.

Am J Med 2020 Jun 26. Epub 2020 Jun 26.

Health Policy, Quality & Informatics Program, Michael E. DeBakey VA Medical Center Health Services Research & Development Center for Innovations in Quality, Effectiveness, and Safety, Houston, TX; Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX; Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX; Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX. Electronic address:

Background: Although the association between autoimmune rheumatic diseases and atherosclerotic cardiovascular disease is well known, there is a lack of data regarding the role of such disorders in patients with premature and extremely premature atherosclerotic cardiovascular disease.

Methods: The VITAL registry including patients with premature (males <55yrs, females <65yrs) and extremely premature atherosclerotic cardiovascular disease (<40yrs), was created from the 2014-2015 nationwide VA health care system database. We assessed age at the time of first cardiovascular event to compare patients with premature (n=135,703) and those with extremely premature atherosclerotic cardiovascular disease (n=7,716) with age-matched patients without atherosclerotic cardiovascular disease (n=1,153,535, n=441,836). Read More

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http://dx.doi.org/10.1016/j.amjmed.2020.05.026DOI Listing
June 2020
5.003 Impact Factor

A Zebra at the Rodeo: Dyspnea, Hematuria, and a Family History of Arthritis.

Arthritis Care Res (Hoboken) 2020 Jun 29. Epub 2020 Jun 29.

Division of Rheumatology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.

An 18-year-old, previously healthy female was admitted for urgent evaluation and management of symptomatic anemia after presenting to her primary care physician with fatigue and shortness of breath. The initial outpatient evaluation was remarkable for hypochromic, microcytic anemia with a hemoglobin of 6.7 g/dL. Read More

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http://dx.doi.org/10.1002/acr.24368DOI Listing

Applying the 2019 EULAR/ACR Lupus Criteria to Patients from the LUMINA Cohort.

Arthritis Care Res (Hoboken) 2020 Jun 29. Epub 2020 Jun 29.

Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, US, United States.

Objective: To evaluate the performance of the 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) criteria for Systemic Lupus Erythematosus (SLE) in terms of earlier SLE classification in comparison to the ACR or the Systemic Lupus International Collaborating Clinics (SLICC) criteria.

Materials And Methods: Patients from a multiethnic, multicenter cohort, the LUMINA cohort, where SLE was defined using the 1982/1997 ACR criteria were included. Demographic, clinical, and immunologic criteria were compared among the 2019 EULAR/ACR and the 1982/1997 ACR and the 2012 SLICC timing categories. Read More

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http://dx.doi.org/10.1002/acr.24367DOI Listing

Understanding the association between osteoarthritis and social participation: a CLSA population-based study.

Arthritis Care Res (Hoboken) 2020 Jun 29. Epub 2020 Jun 29.

Healthcare & Outcomes Research and Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Canada.

Objective: The focus on disability in osteoarthritis (OA) has largely been on performing specific activities, neglecting wider implications for social participation (SP). We investigated the association between OA and SP considering activity limitations (AL) and instrumental supports (IS) as intervening variables in the association.

Methods: Data were from 21,214 respondents aged 45-85 from cycle 1, Canadian Longitudinal Study on Aging. Read More

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http://dx.doi.org/10.1002/acr.24366DOI Listing

Evaluation of Musculoskeletal and Pulmonary Bacterial Infections With [I]FIAU PET/CT.

Mol Imaging 2020 Jan-Dec;19:1536012120936876

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose: Imaging is limited in the evaluation of bacterial infection. Direct imaging of in situ bacteria holds promise for noninvasive diagnosis. We investigated the ability of a bacterial thymidine kinase inhibitor ([I]FIAU) to image pulmonary and musculoskeletal infections. Read More

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http://dx.doi.org/10.1177/1536012120936876DOI Listing

Effect of Underlying Comorbidities on the Infection and Severity of COVID-19 in Korea: a Nationwide Case-Control Study.

J Korean Med Sci 2020 Jun 29;35(25):e237. Epub 2020 Jun 29.

Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Background: The coronavirus disease 2019 (COVID-19) pandemic is an emerging threat worldwide. It remains unclear how comorbidities affect the risk of infection and severity of COVID-19.

Methods: This is a nationwide retrospective case-control study of 219,961 individuals, aged 18 years or older, whose medical costs for COVID-19 testing were claimed until May 15, 2020. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324262PMC

Glucocorticoid use is associated with an increased risk of hypertension.

Rheumatology (Oxford) 2020 Jun 27. Epub 2020 Jun 27.

Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester.

Objectives: Patients with RA are frequently treated with glucocorticoids (GCs), but evidence is conflicting about whether GCs are associated with hypertension. The aim of this study was to determine whether GCs are associated with incident hypertension in patients with RA.

Methods: A retrospective cohort of patients with incident RA and without hypertension was identified from UK primary care electronic medical records (Clinical Practice Research Datalink). Read More

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http://dx.doi.org/10.1093/rheumatology/keaa209DOI Listing

The association between comorbidity and physical activity levels in people with osteoarthritis: Secondary analysis from two randomised controlled trials.

Osteoarthr Cartil Open 2020 Jun;2(2):100057

School of Primary, Community and Social Care, Primary Care Centre Versus Arthritis, Keele University, Keele, ST5 5BG, UK.

Objective: To determine whether comorbidity presence, frequency or type is associated with Physical Activity (PA) levels in people with Osteoarthritis (OA).

Design: Secondary data analysis of adults aged ≥45, with OA related pain recruited to the BEEP trial (knee pain, n = 514) (ISRCTN93634563) and the MOSAICS trial (peripheral joint pain, n = 525) (ISRCTN06984617). Comorbidities considered were respiratory, cardiovascular diseases (CVD), depression, type 2 diabetes and obesity. Read More

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http://dx.doi.org/10.1016/j.ocarto.2020.100057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307638PMC

Factors associated with sepsis risk in immune-mediated inflammatory diseases receiving tumor necrosis factor inhibitors: a nationwide study.

Ther Adv Musculoskelet Dis 2020 16;12:1759720X20929208. Epub 2020 Jun 16.

Department of Medical Research, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sect. 4, Taichung, 40705, ROC.

Background: Risk factors for sepsis have not been assessed in patients receiving tumor necrosis factor-alpha inhibitors (TNFi) for immune-mediated inflammatory diseases (IMIDs) who are vulnerable to serious/hospitalized infections.

Methods: Data from 2003-2017 were obtained from Taiwan's National Health Insurance Research Database to identify patients receiving TNFi, including etanercept, adalimumab, and golimumab, for IMIDs including rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriasis (PsO), psoriatic arthritis (PsA), Crohn's disease (CD), and ulcerative colitis (UC). To investigate risk factors for sepsis, we used the Sepsis-3 definition and calculated hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox regression analysis. Read More

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http://dx.doi.org/10.1177/1759720X20929208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298427PMC

Patient, physiotherapist and surgeon endorsement of the core domain set for total hip and total knee replacement in Germany: a study protocol for an OMERACT initiative.

BMJ Open 2020 Jun 28;10(6):e035207. Epub 2020 Jun 28.

Klinik für Orthopädie, Sportmedizin und Rehabilitation, Krankenhaus Markisch-Oderland GmbH, Wriezen, Germany.

Introduction: There is a lack of harmonising measures for clinical trials on total joint replacement (TJR) that would allow for results from TJR studies to be compared or pooled. The Outcome Measures in Rheumatology (OMERACT) TJR core domain set is already endorsed among patients and physicians in the USA and Australia. Physiotherapists use different types of measurements compared to orthopaedic surgeons while both make substantial contributions to research in the field of TJR. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322286PMC

Pain associated with psoriasis: systematic scoping review protocol.

BMJ Open 2020 Jun 28;10(6):e031461. Epub 2020 Jun 28.

Center for Evidence-Based Medicine and Health Care, Catholic University of Croatia, Zagreb, Croatia

Introduction: Psoriasis is a common chronic skin inflammatory disease. Its presentation, apart from affected skin areas, involves other unpleasant symptoms, such as pain. Pain deteriorates the patient's quality of life, impairing their daily behaviour and functioning. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-031461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322274PMC

Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016.

Rheumatology (Oxford) 2020 Jun 28. Epub 2020 Jun 28.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Objectives: To examine trends in the initial prescription of commonly-prescribed analgesics and patient- as well as practice-level factors related to their selection in incident OA.

Methods: Patients consulting with incident clinical OA between 2000-2016 were identified within The Health Improvement Network in the United Kingdom (UK) general practice. Excluded were patients who had history of cancer or were prescribed the analgesics of interest within 6 months before diagnosis of OA. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa244DOI Listing

Context, context, context: how has covid-19 changed implementation globally and how can we 'lock in' learning?

Rheumatology (Oxford) 2020 Jun 28. Epub 2020 Jun 28.

Department for Allied Health Professionals, Centre for Health and Clinical Research, University of the West of England, Bristol, UK.

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http://dx.doi.org/10.1093/rheumatology/keaa387DOI Listing