24,278 results match your criteria Arthritis care & research[Journal]


Economic Evaluation of Sarilumab in the Treatment of Adult Patients with Moderately-to-Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs.

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

University of Nebraska Medical Center, Omaha, NE, USA.

Introduction: Assess the cost-effectiveness (US healthcare payer perspective) of sarilumab subcutaneous (SC) 200 mg + methotrexate versus conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) or targeted DMARD + methotrexate for moderate-to-severe rheumatoid arthritis (RA) in adults with inadequate response to methotrexate.

Methods: Microsimulation based on patient profiles from MOBILITY (NCT01061736) was conducted via a 6-month decision tree and lifetime Markov model with 6-monthly cycles. Treatment response at 6 months was informed by a network meta-analysis and based on American College of Rheumatology (ACR) response. Read More

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http://dx.doi.org/10.1007/s12325-019-00946-1DOI Listing

[Tight control-Demand for short term control of rheumatoid arthritis].

Z Rheumatol 2019 Apr 18. Epub 2019 Apr 18.

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

The prognosis of rheumatoid arthritis (RA) has been significantly improved in recent decades. This is mainly due to earlier detection, better diagnostics and new treatment options, such as the optimized use of classical disease-modifying antirheumatic drugs (DMARD) and biologicals. Other factors involved were earlier intervention, improved availability of information and analyses and certainly also standardization of care (e. Read More

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http://link.springer.com/10.1007/s00393-019-0631-x
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http://dx.doi.org/10.1007/s00393-019-0631-xDOI Listing
April 2019
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Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing .

Front Immunol 2019 2;10:578. Epub 2019 Apr 2.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

and both contain risk alleles for systemic lupus erythematosus (SLE) and Sjögren's syndrome (pSS). The former escapes X inactivation. Our group predicts specific endolysosomal-dependent immune responses are driven by the protein products of these genes, which form a complex at the endolysosomal surface. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00578
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http://dx.doi.org/10.3389/fimmu.2019.00578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454867PMC
April 2019
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The IL-23/IL-17 pathway in human chronic inflammatory diseases-new insight from genetics and targeted therapies.

Genes Immun 2019 Apr 19. Epub 2019 Apr 19.

Immunoregulation Unit, Department of Immunology, Institut Pasteur, Paris, France.

Chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, spondyloarthritis, and psoriasis cause significant morbidity and are a considerable burden for the patients in terms of pain, impaired function, and diminished quality of life, as well as for society, because of the associated high health-care costs and loss of productivity. Our limited understanding of the pathogenic mechanisms involved in these diseases currently hinders early diagnosis and the development of more specific and effective therapies. The past years have been marked by considerable progress in our insight of the genetic basis of many diseases. Read More

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http://www.nature.com/articles/s41435-019-0067-y
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http://dx.doi.org/10.1038/s41435-019-0067-yDOI Listing
April 2019
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'Acute Flare-Ups' In Patients With, Or At High Risk Of, Knee Osteoarthritis: A Daily Diary Study With Case-Crossover Analysis.

Osteoarthritis Cartilage 2019 Apr 14. Epub 2019 Apr 14.

Clinical Epidemiology, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, UK. Electronic address:

Objective: To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures.

Design: Adults aged ≥45 years with a recent primary care consultation for knee OA/arthralgia completed a daily pen-and-paper diary for up to 3 months, including questions on average knee pain intensity, pain descriptors, other symptoms, activity interference, and selected physical exposures (prolonged kneeling, squatting, climbing stairs, ladders, and moving/lifting heavy objects). Informed by a systematic review, flare-ups were defined a priori. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.003DOI Listing
April 2019
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Combined Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation to Model Inflammatory Lung Disease in Rheumatoid Arthritis.

J Bone Miner Res 2019 Apr 17. Epub 2019 Apr 17.

Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE.

Objectives: Rheumatoid Arthritis (RA) is characterized by extra-articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. The collagen-induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone/joint-lung inflammatory outcomes.

Methods: DBA/1J mice were intranasally treated with saline or ODE daily for 5 weeks. Read More

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http://dx.doi.org/10.1002/jbmr.3745DOI Listing
April 2019
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Care quality for rheumatoid arthritis patients in Quebec.

Int J Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Division of Clinical Epidemiology, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

Aim: The aims of this study were to: (a) measure the proportion of CARTaGENE rheumatoid arthritis (RA) patients fulfilling pre-specified quality indicators (ie disease-modifying antirheumatic drug [DMARD] use, regular follow up, use of folate supplementation, use of vitamin D and calcium, exercise and smoking status); and (b) examine variation in DMARD use with respect to patient age, sex, education and income.

Methods: A cohort of RA patients was constructed based on the CARTaGENE survey and health administrative database. CARTaGENE is a large, established, population-based study which recruited 19 995 participants from four metropolitan regions in Quebec. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13
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http://dx.doi.org/10.1111/1756-185X.13580DOI Listing
April 2019
3 Reads

Development of a methotrexate educational guide/information/monitoring booklet for inflammatory arthritis.

Musculoskeletal Care 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology, University Hospital Waterford, Waterford, Ireland.

Introduction: There are over 40,000 people living in Ireland with inflammatory arthritis (IA), a condition that is potentially destructive in nature and can have personal, social and economic consequences. Although we have witnessed dramatic changes in the treatment of IA in the last two decades, methotrexate (MTX) remains the first-line treatment for patients with a diagnosis of IA. Despite the fact that MTX is so commonly prescribed, there is a lack of educational materials both for healthcare professionals (HCPs) and patients. Read More

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http://dx.doi.org/10.1002/msc.1398DOI Listing

Obstetric outcomes in women with rheumatoid arthritis: Results from Nationwide Inpatient Sample Database 2003-2011.

Semin Arthritis Rheum 2019 Mar 23. Epub 2019 Mar 23.

University of Mississippi, 2500 North State Street, Jackson, MS 39232, United States.

Objective: Fertility is reduced in patients with Rheumatoid Arthritis due to unknown cause. Few studies have addressed pregnancy outcomes in RA. This study was undertaken to determine the frequency of complications occurring during pregnancy for women with RA and compare with the general obstetric population by using the largest inpatient care database. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.011DOI Listing
March 2019
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[Mufangji Decoction formula tracing and its effect on emergency and severe cases].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):388-400

Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.

Mufangji Decoction is a famous herbal formula from Synopsis of Golden Chamber. However,it is easy to be misunderstood due to so its unique compatability. The syndromes treated by Mufangji Decoction included the following aspects:(1) in terms of modern medicine,it could be used to treat acute and chronic heart failure,heart failure aggravated by lung infection,chronic obstructive pulmonary disease acute episode,pulmonary heart disease,bilateral pleural effusion,acute attack of gout,rheumatic fever,rheumatoid arthritis,and rheumatoid arthritis;(2) in terms of symptoms,it could be used to treat asthma,chest tightness,wheeze impacting prostration and dyspnea impacting sitting posture; gastric distention; dark face,cyanotic,and mitral valvular face; edema of head and extremities; dry mouth,thirsty,unwilling to wear thick clothes,intolerance of heat,and irritable; fatigue,shortness of breath,poor appetite,constipation,less urine,yellow color,poor response to diuretics,and diuretic resistance; fast heart rate,which is hard to be controlled by Western medicine and has no response to Zhenwu Decoction; dark red tongue,dry tongue with yellow fur,rapid pulse,or deep tight pulse. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.2019.0009
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http://dx.doi.org/10.19540/j.cnki.cjcmm.2019.0009DOI Listing
January 2019
2 Reads

Aspects of exercise with person-centred guidance influencing the transition to independent exercise: a qualitative interview study among older adults with rheumatoid arthritis.

Eur Rev Aging Phys Act 2019 5;16. Epub 2019 Apr 5.

1Department of Health and Rehabilitation, Unit of Physiotherapy, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Box 455, 405 30 Göteborg, Gothenburg, Sweden.

Background: Besides being health enhancing and disease preventing, exercise is also an important part of the management of chronic conditions, including the inflammatory joint disease rheumatoid arthritis (RA). However, older adults with RA present a lower level of physical activity than healthy older adults. The aim of this qualitative study was to explore aspects of participation in moderate- to high-intensity exercise with person-centred guidance influencing the transition to independent exercise for older adults with RA. Read More

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http://dx.doi.org/10.1186/s11556-019-0211-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449916PMC
April 2019
2 Reads

Anti-CCP3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis.

J Rheumatol 2019 Apr 15. Epub 2019 Apr 15.

From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors' sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email:

Objective: We investigated the association of age and anti-cyclic citrullinated peptide (CCP) antibodies in subjects without RA.

Methods: Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDRs) of RA patients and 330 osteoarthritis (OA) subjects. Read More

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http://dx.doi.org/10.3899/jrheum.180897DOI Listing
April 2019
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Patient preferences for disease modifying anti-rheumatic drug treatment in rheumatoid arthritis: A systematic review.

J Rheumatol 2019 Apr 15. Epub 2019 Apr 15.

From the Department of Medicine and Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta; Arthritis Research Canada; Centre for Health Evaluation and Outcome Sciences, Providence Health Care, St Paul's Hospital, Vancouver, British Columbia. The work was supported in part by a Canadian Initiative for Outcomes in Rheumatology Care (CIORA) grant. Dr. Hazlewood is supported by a Canadian Institute of Health Research (CIHR) New Investigator Salary Award and The Arthritis Society Young Investigator Salary Award. Dr. Marshall is supported by a CIHR Canada Research Chair in Health Services and Systems Resea. Address correspondence to Dr. Glen Hazlewood, 3330 Hospital Dr NW, Calgary, Alberta, Canada, T2N 4N1 Tel: (403) 220-5903, Fax: (403) 210-7367 Email:

Objective: To summarize patients' preferences for disease modifying anti-rheumatic drug (DMARD) therapy in rheumatoid arthritis (RA).

Methods: We conducted a systematic review to identify English-language studies in adult RA patients that measured patients' preferences for DMARDs or health states and treatment outcomes relevant to DMARD decisions. Study quality was assessed using a published quality assessment tool. Read More

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http://dx.doi.org/10.3899/jrheum.181165DOI Listing
April 2019
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Effect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results.

J Rheumatol 2019 Apr 15. Epub 2019 Apr 15.

From McMaster University, Hamilton, Ontario; Southlake Regional Health Centre, Newmarket, Ontario; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario; JSS Medical Research; McGill University, Montreal, Quebec; University of Toronto, Department of Medicine and Institute of Health Policy, Management, and Evaluation; Mount Sinai Hospital, Division of Rheumatology, Toronto, Ontario, Canada. OBRI was funded by peer-reviewed grants from Canadian Institute for Health Research (CIHR), Ontario Ministry of Health and Long-Term Care (MOHLTC), Canadian Arthritis Network (CAN), and unrestricted grants from AbbVie, Amgen, Celgene, Hospira, Janssen, Lilly, Merck, Novartis, Pfizer, Roche, Sanofi, and UCB. MM, AC, XL, SC, and CB are employees at OBRI, which was funded by peer-reviewed grants from CIHR, MOHLTC, CAN, and unrestricted grants from AbbVie, Amgen, Bristol Myers Squibb, Celgene, Hospital Janssen, Pfizer, Roche, Sanofi, and UCB. ER and JSS are employees at JSS Medical Research, a contract research organization. A.N. Lau, MD, McMaster University; J.C. Thorne, MD, Southlake Regional Health Centre; M. Movahedi, MD, PhD, Toronto General Hospital Research Institute, University Health Network; E. Rampakakis, PhD, JSS Medical Research; A. Cesta, BSc, Toronto General Hospital Research Institute, University Health Network; X. Li, BSc, Toronto General Hospital Research Institute, University Health Network; S. Couto, MSc, Toronto General Hospital Research Institute, University Health Network; J. Sampalis, PhD, JSS Medical Research, and McGill University; C. Bombardier, MD, Toronto General Hospital Research Institute, University Health Network, and University of Toronto, Department of Medicine and Institute of Health Policy, Management, and Evaluation, and Mount Sinai Hospital, Division of Rheumatology. Address correspondence to Dr. A.N. Lau, 501-25 Charlton Ave. East, Hamilton, Ontario L8N 1Y2, Canada. E-mail: Accepted for publication October 30, 2018.

Objective: Prior studies have suggested that concurrent conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy enhances the efficacy of biologic DMARD (bDMARD). Here, we assessed the effect of concomitant csDMARD use and methotrexate (MTX) route of administration on time to bDMARD discontinuation in a large Canadian (Ontario), observational, rheumatoid arthritis (RA) cohort.

Methods: Patients from the Ontario Best Practices Research Initiative (OBRI) who initiated bDMARD therapy and had ≥ 1 followup assessment were included. Read More

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http://dx.doi.org/10.3899/jrheum.180486DOI Listing
April 2019
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Report on the 2018 Cancer, Autoimmunity, and Immunology Conference.

J Immunol 2019 Apr 15. Epub 2019 Apr 15.

Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

With the increased use of cancer immunotherapy, a number of immune-related adverse events (irAEs) are being identified. These irAEs can be compared with known autoimmune disorders in similar tissues, with important similarities and differences. Understanding the etiology of irAEs may bring to light concepts applicable to immune responses in cancer, autoimmunity, and infectious disease. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1900264
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http://dx.doi.org/10.4049/jimmunol.1900264DOI Listing
April 2019
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[Real World Management of Gouty Arthritis: Clinical, Epidemiological and Comorbidity Data from 4016 Patients in Rhineland-Palatinate, Germany].

Dtsch Med Wochenschr 2019 Apr 15;144(8):e51-e57. Epub 2019 Apr 15.

ACURA Rheuma-Kliniken, Bad Kreuznach, Deutschland.

Background:  To examine clinical, comorbidity and demographic aspects of gout and to explore the routine clinical practice of gout treatment among general practitioners (G.P.'s) in southwest Germany. Read More

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http://dx.doi.org/10.1055/a-0755-1341DOI Listing
April 2019
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Ambulatory status after surgical and nonsurgical treatment for spinal metastasis.

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Decisions for operative or nonoperative management remain challenging for patients with spinal metastases, especially when life expectancy and quality of life are not easily predicted. This study evaluated the effects of operative and nonoperative management on maintenance of ambulatory function and survival for patients treated for spinal metastases.

Methods: Propensity matching was used to yield an analytic sample in which operatively and nonoperatively treated patients were similar with respect to key baseline covariates. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32140
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http://dx.doi.org/10.1002/cncr.32140DOI Listing
April 2019
2 Reads

Shoulder Arthroplasty for a Fracture Is Not the Same as Shoulder Arthroplasty for Osteoarthritis: Implications for a Bundled Payment Model.

J Am Acad Orthop Surg 2019 Apr 11. Epub 2019 Apr 11.

From the Department of Orthopaedics, Wexner Medical Center at The Ohio State University Columbus, OH.

Introduction: The Center for Medicare Services currently bundles all shoulder arthroplasties, total shoulder arthroplasty and reverse total shoulder arthroplasty, into one Diagnosis-Related Group on which bundled reimbursements are then further characterized. An arthroplasty performed for traumatic indications, such as fractures, may have a different postoperative course of care compared with the one being done for degenerative arthritis/osteoarthritis (OA), despite having the same Current Procedural Terminology (CPT) and Diagnosis-related Group code.

Methods: The 2012 to 2016 American College of Surgeons-National Surgical Quality Improvement Program databases were queried using CPT-23472 to retrieve records of patients undergoing total shoulder arthroplasty/reverse total shoulder arthroplasty for degenerative arthritis/OA or proximal humerus fracture. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00268DOI Listing
April 2019
1 Read

Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis.

J Family Med Prim Care 2019 Feb;8(2):517-522

Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India.

Background: To assess effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis (RA).

Materials And Methods: An open-labeled randomized trial was conducted comparing 60,000 IU 1,25 dihydroxy vitamin D3 + calcium (1000 mg/day) combination [Group A] versus calcium (1000 mg/day) only [Group B], as supplement to existing treatment regimen in early RA. Primary outcome included (i) minimum time required for onset of pain relief (Tm) assessed through patients' visual analog scale (VAS); (ii) % change in VAS score from onset of pain relief to end of 8 weeks. Read More

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http://www.jfmpc.com/text.asp?2019/8/2/517/253057
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http://dx.doi.org/10.4103/jfmpc.jfmpc_446_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436291PMC
February 2019
2 Reads

Chronicity of Mental Comorbidity in Children with New-onset Physical Illness.

Child Care Health Dev 2019 Apr 14. Epub 2019 Apr 14.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Background: Evidence suggests that physical and mental illness are strongly correlated in children. This study examined patterns of the chronicity of multimorbidity (co-occurring physical and mental illness); estimated homotypic continuity; and, modelled factors associated with chronicity in children newly diagnosed with a chronic physical illness.

Methods: Children aged 6-16 years diagnosed with one of asthma, diabetes, epilepsy, food allergy, or juvenile arthritis were recruited from two children's hospitals and followed for six months. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cch.12667
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http://dx.doi.org/10.1111/cch.12667DOI Listing
April 2019
2 Reads

Polypharmacy is associated with treatment response and serious adverse events: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Rheumatology (Oxford) 2019 Apr 14. Epub 2019 Apr 14.

Department of Inflammation Biology, School of Immunology & Microbial Sciences.

Objective: To evaluate whether polypharmacy is associated with treatment response and serious adverse events (SAEs) in patients with RA using data from the British Society for Rheumatology Biologics Register (BSRBR-RA).

Methods: The BSRBR-RA is a prospective observational cohort study of biologic therapy starters and a DMARD comparator arm. A logistic regression model was used to calculate the odds of a EULAR 'good response' after 12 months of biologic therapy by medication count. Read More

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http://dx.doi.org/10.1093/rheumatology/kez037DOI Listing
April 2019
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Gender differences in information needs and preferences regarding depression among individuals with multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis.

Patient Educ Couns 2019 Apr 6. Epub 2019 Apr 6.

Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Objective: We assessed the information needs of persons with any of three immune-mediated inflammatory diseases (multiple sclerosis [MS], inflammatory bowel disease [IBD] and rheumatoid arthritis [RA]) regarding depression, as a first step toward developing patient-relevant information resources, ultimately to facilitate self-management and appropriate care. We also compared information needs across genders.

Methods: We surveyed participants with MS, IBD and RA regarding depression-related information needs including types of treatments, effectiveness, risks, benefits, and perceived helpfulness of treatments. Read More

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http://dx.doi.org/10.1016/j.pec.2019.04.007DOI Listing
April 2019
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Efficacy and Safety of Intravenous Golimumab through 1 Year in Patients with Active Psoriatic Arthritis.

Arthritis Care Res (Hoboken) 2019 Apr 12. Epub 2019 Apr 12.

Janssen Research & Development, LLC, Spring House, PA, USA.

Objective: Evaluate safety and efficacy of intravenous golimumab in patients with active psoriatic arthritis (PsA) through 1 year.

Methods: GO-VIBRANT was a Phase 3, randomized, placebo-controlled trial of 480 adults with active PsA. Patients were randomized to intravenous placebo (n=239) or golimumab 2 mg/kg (n=241) at weeks 0, 4, 12, and 20, with placebo crossover to golimumab at weeks 24, 28, and q8w. Read More

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http://dx.doi.org/10.1002/acr.23905DOI Listing
April 2019
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A Systematic Review and Appraisal of the Cross-Cultural Validity of Functional Status Assessments Measures in Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2019 Apr 12. Epub 2019 Apr 12.

Department of Medicine & Department of Community Health Sciences, Cumming School of Medicine, University of Calgary; Arthritis Research Canada, Calgary, Alberta, Canada.

Objective: We conducted a systematic review and appraisal of the cross-cultural adaptation and cross-cultural validity of the Health Assessment Questionnaire (HAQ) and its derivatives, and the more recent Patient-Reported Outcomes Measurement Information System (PROMIS) Functional Status Assessment Measures (FSAMs) in rheumatoid arthritis (RA).

Methods: Four electronic medical databases were searched from inception until April 4 , 2018 according the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) group search strategy. Included studies were evaluated using the COSMIN tool for cross-cultural validity and were scored as excellent, good, fair or poor. Read More

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http://dx.doi.org/10.1002/acr.23904DOI Listing
April 2019
2 Reads

Comorbid interphalangeal joint pain and erosive osteoarthritis are associated with worse hand function in individuals with symptomatic thumb base OA.

Arthritis Care Res (Hoboken) 2019 Apr 12. Epub 2019 Apr 12.

Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, The University of Sydney, Sydney, New South Wales, Australia.

Objective: Hand osteoarthritis (OA) trials often target exclusively the thumb base joint although concomitant widespread interphalangeal (IP) involvement is frequent. We aimed to compare hand strength and function between individuals with isolated thumb base OA and those with co-existent IP joint pain and erosive OA.

Methods: Baseline data from a thumb base OA trial was analysed (n=204). Read More

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http://dx.doi.org/10.1002/acr.23902DOI Listing
April 2019
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The Potential Role of Cost and Quality of Life in Treatment Decisions for Arthritis-related Knee Pain for African American and Latina Women.

Arthritis Care Res (Hoboken) 2019 Apr 12. Epub 2019 Apr 12.

MedStar Harborview Hospital, Baltimore, MD.

Objective: This study ascertains whether Latina and African American women with arthritis-related knee pain and primary care providers who treat them believe their treatment decisions would benefit from having more information about the impact of treatment on their quality of life, medical care costs and work productivity.

Methods: We conducted four focus groups of Latina and African American women over the age of 45 who had knee pain. Also, we conducted two focus groups with primary care providers who treated Latina and African American women for knee pain. Read More

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http://dx.doi.org/10.1002/acr.23903DOI Listing

Clinical characteristics of patients with polymicrobial septic arthritis.

Eur J Clin Microbiol Infect Dis 2019 Apr 13. Epub 2019 Apr 13.

Azrieli Faculty of Medicine, Bar-ilan University, Ramat Gan, Israel.

Little is known about the incidence, risk factors, clinical characteristics, and outcomes of patients with polymicrobial SA (PMSA). We aimed to determine the unique characteristics of patients with PMSA by comparing them to patients with monomicrobial SA (MMSA). We conducted a retrospective cohort study of patients 18 years and older admitted to a single tertiary care medical center, between 1998 and 2015, with surgically treated culture-positive SA affecting one or more joints. Read More

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http://dx.doi.org/10.1007/s10096-019-03557-4DOI Listing
April 2019
1 Read

Ephrins and Eph Receptor Signaling in Tissue Repair and Fibrosis.

Curr Rheumatol Rep 2019 Apr 12;21(6):23. Epub 2019 Apr 12.

The Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Purpose Of Review: Fibrosis is a pathological feature of many human diseases that affect multiple organs. The development of anti-fibrotic therapies has been a difficult endeavor due to the complexity of signaling pathways associated with fibrogenic processes, complicating the identification and modulation of specific targets. Evidence suggests that ephrin ligands and Eph receptors are crucial signaling molecules that contribute to physiological wound repair and the development of tissue fibrosis. Read More

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http://dx.doi.org/10.1007/s11926-019-0825-xDOI Listing

Intensive management for moderate rheumatoid arthritis: a qualitative study of patients' and practitioners' views.

BMC Rheumatol 2019 28;3:12. Epub 2019 Mar 28.

1Department of Inflammation Biology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, 10 Cutcombe Road, Denmark Hill, London, SE5 9RJ UK.

Background: The TITRATE trial seeks to test whether intensive management is valuable in achieving disease remission in moderately active rheumatoid arthritis. Intensive management is a complex intervention consisting of: 1) 12 x monthly appointments, 2) tailored 'treatment support' based on motivational interviewing techniques, 3) optimised medication (including the opportunity for biologics), 4) provision of a Patient Handbook, and 5) shared treatment planning. This study aims to understand: a) patients' and practitioners' views on the feasibility and acceptability of intensive management, and b) patients' and practitioners' experience of receiving/providing intensive management. Read More

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http://dx.doi.org/10.1186/s41927-019-0057-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437952PMC

Cumulative Incidence of Orofacial Manifestations in Early Juvenile Idiopathic Arthritis: A Regional, Three Year Cohort Study.

Arthritis Care Res (Hoboken) 2019 Apr 11. Epub 2019 Apr 11.

Section of Orthodontics, Aarhus University, Denmark and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark.

Objectives: To estimate the cumulative incidence of arthritis-induced orofacial symptoms, dysfunctions, and dentofacial deformities in growing individuals with juvenile idiopathic arthritis (JIA) in a 36 month regional cohort study, and to identify predictors for the development of arthritis-induced dentofacial deformities.

Methods: Data was retrieved from the Aarhus JIA TMJ cohort register, which contains standardized, longitudinal, observational data regarding orofacial conditions in patients with JIA (n=1040). This regional cohort represents the majority of all subjects with JIA from the western part of Denmark between 1990 and 2016, regardless of temporomandibular joint (TMJ) arthritis status. Read More

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http://dx.doi.org/10.1002/acr.23899DOI Listing

Strategies for optimising musculoskeletal health in the 21 century.

BMC Musculoskelet Disord 2019 Apr 11;20(1):164. Epub 2019 Apr 11.

School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.

We live in a world with an ever-increasing ageing population. Studying healthy ageing and reducing the socioeconomic impact of age-related diseases is a key research priority for the industrialised and developing countries, along with a better mechanistic understanding of the physiology and pathophysiology of ageing that occurs in a number of age-related musculoskeletal disorders. Arthritis and musculoskeletal disorders constitute a major cause of disability and morbidity globally and result in enormous costs for our health and social-care systems. Read More

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http://dx.doi.org/10.1186/s12891-019-2510-7DOI Listing
April 2019
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Predicting Periarticular Infection in Children With Septic Arthritis of the Hip: Regionally Derived Criteria May Not Apply to All Populations.

J Pediatr Orthop 2019 May/Jun;39(5):268-274

The Children's Hospital of Philadelphia, Philadelphia, PA.

Background: The management of septic arthritis of the hip in children can be complicated by the presence of additional coexisting periarticular infections (PAIs). Criteria predicting the presence of PAI have recently been proposed by Rosenfeld and colleagues with the goal of using magnetic resonance imaging (MRI) efficiently in the workup of septic arthritis. The purpose of this study was to determine the applicability of recently published predictive criteria for PAI (developed in the Southwestern United States using a variety of joints) to septic arthritis of the hip treated at a large Northeastern tertiary care center. Read More

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http://dx.doi.org/10.1097/BPO.0000000000000934DOI Listing
April 2019
1 Read

Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase.

Sensors (Basel) 2019 Apr 8;19(7). Epub 2019 Apr 8.

School of Engineering and Material Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.

Peptide cross-linked poly(ethylene glycol) hydrogel has been widely used for drug delivery and tissue engineering. However, the use of this material as a biosensor for the detection of collagenase has not been explored. Proteases play a key role in the pathology of diseases such as rheumatoid arthritis and osteoarthritis. Read More

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http://dx.doi.org/10.3390/s19071677DOI Listing

Drug-related problems in patients with rheumatoid arthritis.

Ther Clin Risk Manag 2019 21;15:505-524. Epub 2019 Mar 21.

Division of Rheumatology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: Rheumatoid arthritis (RA) patients are at risk of acquiring drug-related problems (DRPs). However, there has been a lack of studies on DRPs in patients with RA up to now.

Method: This retrospective study was conducted in a tertiary hospital in Malaysia from January 2012 to December 2017 with the purpose of assessing DRPs in RA patients and factors associated with its occurrence. Read More

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http://dx.doi.org/10.2147/TCRM.S194921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432894PMC
March 2019
3 Reads

The ILD-GAP risk prediction model performs poorly in myositis-associated interstitial lung disease.

Respir Med 2019 Apr 21;150:63-65. Epub 2019 Feb 21.

Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 500, Baltimore, MD, 21224, USA. Electronic address:

Purpose: Myositis-associated interstitial lung disease (MA-ILD) is associated with increased mortality, but no prognostic model exists in this population. The ILD-GAP index was developed to predict mortality risk across all subtypes of chronic ILD. The purpose of this study was to validate the ILD-GAP risk prediction model in patients with MA-ILD. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461370PMC
April 2019
1 Read

The Epidemiology of Antiphospholipid Syndrome. A Population-Based Study.

Arthritis Rheumatol 2019 Apr 8. Epub 2019 Apr 8.

Division of Rheumatology, Department of Medicine, Mayo Clinic. Rochester, MN, . USA.

Objective: To estimate the incidence, prevalence and mortality of antiphospholipid syndrome (APS).

Methods: An inception cohort of patients with incident APS in 2000-2015 in a geographically well-defined population was identified based on comprehensive individual medical record review. All cases met the 2006 Sydney APS criteria (primary definition) or had APS by physician consensus (secondary definition). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/art.40901
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http://dx.doi.org/10.1002/art.40901DOI Listing
April 2019
3 Reads

Comparison of Janus kinase inhibitors in the treatment of rheumatoid arthritis: a systemic literature review.

Immunotherapy 2019 Apr 8. Epub 2019 Apr 8.

University of Western Ontario, Schulich School of Medicine & Dentistry, Department of Medicine, London, ON, Canada.

Several Janus kinase (JAK) inhibitors, oral targeted disease-modifying drugs, will be approved for the treatment of rheumatoid arthritis (RA) and other diseases. This review compares and contrasts the efficacy of JAK inhibitors (tofacitinib, baricitinib, upadacitinib, filgotinib, peficitinib and decernotinib) in RA including: early RA methotrexate-naive patients, post methotrexate failure and post biologics. Trials in monotherapy, combination with disease modifying drugs such as methotrexate, and comparing with adalimumab in biologic-naive patients were studied. Read More

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http://dx.doi.org/10.2217/imt-2018-0178DOI Listing

Trajectories of pain predict disabilities affecting daily living in arthritis.

Br J Health Psychol 2019 Apr 7. Epub 2019 Apr 7.

School of Psychology, University of Nottingham, UK.

Purpose: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis heterogeneously, with subgroups of people having different trajectories of pain. However, at present it is unclear how these pain trajectories are related to functional disability. Read More

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http://dx.doi.org/10.1111/bjhp.12364DOI Listing
April 2019
2 Reads

A clinical model for identifying an inflammatory phenotype in mood disorders.

J Psychiatr Res 2019 Feb 10;113:148-158. Epub 2019 Feb 10.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; VA Palo Alto Health Care System, Palo Alto, CA, USA.

Increasingly, clinical research has found inflammatory correlates of psychiatric disorders, particularly mood symptomatology. Biological measures may provide greater precision in many cases and may capture clinically-relevant inflammatory signposts, such as central obesity risk, inflammation-associated co-morbid medical conditions, or proinflammatory lifestyle choices. In order to expand understanding of the role of inflammation in mood disorders, we propose a more inclusive clinical model for capturing an inflammatory phenotype of depression by identifying clinically-relevant inflammatory phenotypes grounded in biology. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.005DOI Listing
February 2019
3 Reads

Comparison of Sex-Based Differences in Home or Nonhome Discharge Utilization of Rehabilitative Services and Outcomes Following Transcatheter Aortic Valve Implantation in the United States.

Am J Cardiol 2019 Mar 19. Epub 2019 Mar 19.

Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Sex-based differences in outcomes have been shown to affect caregiving in medical disciplines.Increased spending due to postacute care transfer policies has led hospitals to further scrutinize patient outcomes and disposition patterns after inpatient admissions. We examined sex-based differences in rehabilitative service utilization after transcatheter aortic valve implantation (TAVI). Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.03.008DOI Listing
March 2019
4 Reads

Patient reported outcome data from the Care in Early Rheumatoid Arthritis trial: Opportunities for broadening the scope of treating to target.

Arthritis Care Res (Hoboken) 2019 Apr 5. Epub 2019 Apr 5.

University Hospitals Leuven, Department of Rheumatology.

Objective: Treating early, intensively and to target leads to rapid disease control, preventing joint damage and loss of function in early rheumatoid arthritis (RA). We report the effect of such approach on patient-reported outcomes and explore the contribution of rapid and persistent disease control on wellbeing after 1 year of treatment.

Methods: This study is part of the Care in early RA trial, a prospective, 2-year, investigator-initiated, randomized controlled trial rooted in daily practice and implementing the treat-to-target principle. Read More

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http://dx.doi.org/10.1002/acr.23900DOI Listing
April 2019
2 Reads

Depression Subtypes in Persons with or at Risk for Symptomatic Knee Osteoarthritis.

Arthritis Care Res (Hoboken) 2019 Apr 5. Epub 2019 Apr 5.

VA Maryland Health Care System, Baltimore, MD, USA.

Objective: To identify depression subtypes in participants with or at-risk for symptomatic knee osteoarthritis (OA) and to evaluate differences in pain and disability trajectories between groups.

Methods: Participants (n=4486) were enrolled in the Osteoarthritis Initiative. Latent class analysis (LCA) was applied to the 20-Item Center for Epidemiological Studies Depression Scale measured at baseline to identify groups with similar patterns of depressive symptoms, and subtypes were assigned using poster probability estimates. Read More

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http://dx.doi.org/10.1002/acr.23898DOI Listing
April 2019
3 Reads

Prevalence of giant cell arteritis relapse in patients treated with glucocorticoids: a meta-analysis.

Arthritis Care Res (Hoboken) 2019 Apr 5. Epub 2019 Apr 5.

Univ Lyon, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, CNRS, Claude Bernard University Lyon, F-69003, France.

Objective: The relapse rate of patients with giant cell arteritis (GCA) treated with glucocorticoids (GC) alone varied widely in observational series and randomized controlled trials (RCT). The purpose of this systematic review was to evaluate the prevalence of relapse and predisposing factors in patients receiving GC alone.

Methods: We searched MedLine up to December 2017. Read More

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http://dx.doi.org/10.1002/acr.23901DOI Listing
April 2019
3 Reads

Rheumatoid arthritis disease activity predicting incident clinically-apparent RA-associated interstitial lung disease: A prospective cohort study.

Arthritis Rheumatol 2019 Apr 5. Epub 2019 Apr 5.

Harvard Medical School, Boston, MA.

Objective: To evaluate rheumatoid arthritis (RA) disease activity and risk for RA-associated interstitial lung disease (RA-ILD).

Methods: We investigated disease activity and RA-ILD risk using the Brigham RA Sequential Study (BRASS, 2003-2016). All subjects had RA according to accepted criteria. Read More

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http://dx.doi.org/10.1002/art.40904DOI Listing
April 2019
3 Reads

Pediatric Septic Arthritis of the Knee: Predictors of Septic Hip Do Not Apply.

J Pediatr Orthop 2019 Apr 3. Epub 2019 Apr 3.

Washington University School of Medicine, Pediatric and Adolescent Orthopedic Surgery Washington University Orthopaedics, St. Louis, MO.

Background: The early diagnosis of pediatric septic arthritis is paramount to the prevention of long-term sequela. The purpose of this study is to investigate if the commonly used criteria developed by Kocher and colleagues for hip septic arthritis can be used for screening children with suspected septic knee.

Methods: We retrospectively reviewed the charts of patients under the age of 19, between June 2002 to June 2017, who presented to a major tertiary-care children's hospital with septic knee. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001377DOI Listing

Canadians' views on the use of routinely collected data in health research: a patient-oriented cross-sectional survey.

CMAJ Open 2019 Apr-Jun;7(2):E203-E209. Epub 2019 Apr 4.

Arthritis Research Canada (McCormick, Hamilton, Li), Richmond, BC; Department of Physical Therapy (Hamilton, Li), University of British Columbia; Arthritis Consumer Experts (Koehn), Vancouver, BC; Arthritis Patients Advisory Board (English), Arthritis Research Canada, Richmond, BC; Canadian Skin Patient Alliance (Stordy), Calgary, Alta.

Background: Little is known about Canadians' knowledge of and level of support for using administrative and other large, routinely collected data for health research, despite the benefits of this type of research to patients, health care systems and society. We sought to benchmark the views of Canadian adults on this topic.

Methods: Researchers and patient leaders of 3 joint and skin disease organizations codeveloped a cross-sectional online survey that was conducted between January and August 2017. Read More

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http://dx.doi.org/10.9778/cmajo.20180105DOI Listing
April 2019
1 Read

Impact of antimalarial (AM) on serum lipids in systemic lupus erythematosus (SLE) patients: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Apr;98(14):e15030

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Dyslipidemia is a common disorder in systemic lupus erythematosus (SLE) patients. It is still inconclusive whether antimalarial drugs could affect the serum lipids in SLE patients, therefore we conducted a systematic review and meta-analysis of available data to address this issue.

Methods: We comprehensively searched the databases of PubMed, EMBASE and Cochrane Library from date of inception to Sep 2018 for both randomized controlled trials (RCTs) and observational studies. Read More

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http://dx.doi.org/10.1097/MD.0000000000015030DOI Listing
April 2019
2 Reads

Risk of Parkinson disease in Sjögren syndrome administered ineffective immunosuppressant therapies: A nationwide population-based study.

Medicine (Baltimore) 2019 Apr;98(14):e14984

Department of Medical Research, China Medical University HsinChu Hospital, HsinChu County, China Medical University.

To determine the incidence and risk of Parkinson disease (PD) in patients with Sjögren syndrome (SS) according to a nationwide population-based database.In total, 12,640 patients in the SS cohort and 50,560 in the non-SS cohort were enrolled from Taiwan's National Health Insurance Research Database from 2000 to 2010. We used the Cox multivariable proportional hazards model to determine the risk factors for PD in the SS cohort. Read More

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http://dx.doi.org/10.1097/MD.0000000000014984DOI Listing
April 2019
3 Reads

Ultrasound as a Useful Tool in the Diagnosis of Rheumatoid Arthritis in Patients With Undifferentiated Arthritis.

J Clin Rheumatol 2019 Apr 3. Epub 2019 Apr 3.

Center of Rheumatoid Arthritis, BIOMAB, Bogota, Colombia.

Background: Nowadays, rheumatologists face challenges in finding an effective method to classify and treat patients with undifferentiated arthritis (UA). There is a need for new tools that could ensure accurate characterization of inflammatory processes in these patients.

Objective: The aim of this study was to investigate if a characterization of UA patients using ultrasound (US) may help to fulfill the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) rheumatoid arthritis (RA) classification criteria in a real-life cohort. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001034DOI Listing
April 2019
2 Reads