665 results match your criteria Arthritis as a Manifestation of Systemic Disease


Disorders of the Aorta and Aortic Valve in Connective Tissue Diseases.

Curr Cardiol Rep 2020 Jun 19;22(8):70. Epub 2020 Jun 19.

Department of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.

Purpose Of Review: The incidence of aortic valve disease in inherited connective tissue disorders is well documented; however, recent studies have only begun to unravel the pathology behind this association. In this review, we aim to describe the etiology, clinical manifestations, management, and prognosis of aortic and aortic valvular disorders that co-exist in a variety of connective tissue diseases. An extensive literature review was performed in PubMed. Read More

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http://dx.doi.org/10.1007/s11886-020-01314-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305067PMC

Patients with specific skin disorders who are affected by COVID-19: What do experiences say about management strategies? A systematic review.

Dermatol Ther 2020 Jun 18:e13867. Epub 2020 Jun 18.

Department of Dermatology, Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.

In patients with specific dermatologic disorders who are affected by new corona virus, we know little about disease course (underlying disease and new onset infection), and the most proper management strategies include both issues that are what this systematic review targets. Databases of PubMed, Scopus, Google Scholar, Medscape, and Centre of Evidence-Based Dermatology, coronavirus dermatology resource of Nottingham University searched completely up to May 15, 2020, and initial 237 articles were selected to further review and finally 9 articles (including 12 patients) entered to this study. From 12 patients with chronic underlying dermatologic disease treated with systemic therapies, only 1 patient required Intensive Care Unit admission, the others have been treated for mild-moderate symptoms with conventional therapies. Read More

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http://dx.doi.org/10.1111/dth.13867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323037PMC

Secondary vasculitis - omitted manifestation of many diseases.

Authors:
Radim Bečvář

Cesk Patol 2020 ;56(2):83-88

Secondary vasculitides usually accompany various common and rare conditions, Their clinical picture is very diverse, they can be loclaized or genaralized. Most frequently, we find parainfectious, drug-related and paraneoplastic vasculitides, less commonly in connective tissue diseases, after radiotherapy or transplantation. Vasculitides may be associated to infection of any origin. Read More

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January 2020

Rheumatologic Disorders and the Nervous System.

Continuum (Minneap Minn) 2020 06;26(3):591-610

Purpose: This article describes the neurologic manifestations of systemic autoimmune diseases.

Recent Findings: Systemic autoimmune diseases can be associated with a wide spectrum of neurologic comorbidities involving the central and peripheral nervous systems. Systemic lupus erythematosus (SLE) can be associated with a number of manifestations predominantly affecting the central nervous system (CNS), whereas peripheral neuropathy is less common. Read More

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http://dx.doi.org/10.1212/CON.0000000000000856DOI Listing

Cutaneous manifestations of anti-neutrophil cytoplasmic antibody-associated vasculitis.

Arthritis Rheumatol 2020 May 18. Epub 2020 May 18.

Division of Rheumatology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

Objective: Cutaneous manifestations of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), are poorly characterized. This study describes the dermatologic features of AAV and their association with systemic manifestations of vasculitis.

Methods: A cross-sectional study describing and comparing the cutaneous manifestations of AAV was performed using data from a large, international, collaborative effort to collect comprehensive clinical data on patients with vasculitis. Read More

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http://dx.doi.org/10.1002/art.41310DOI Listing

Neurophysiological assessment of joint nociceptors in the rat medial meniscus transection model of post-traumatic osteoarthritis.

Osteoarthritis Cartilage 2020 May 13. Epub 2020 May 13.

Departments of Pharmacology and Anaesthesia, Pain Management & Perioperative Medicine, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, B3H 4R2, Canada. Electronic address:

Objective: Meniscal injury is a common prelude to post-traumatic osteoarthritis (PTOA). Joint nerves can become damaged in arthritic joints leading to the manifestation of neuropathic pain. Both PTOA and neuropathic pain are more common in females; however, it is unknown whether the neural processing of joint pain is sex-specific. Read More

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http://dx.doi.org/10.1016/j.joca.2020.05.004DOI Listing

Association of markers of rheumatoid arthritis in lupus. Is it a rhupus?

Ann Biol Clin (Paris) 2020 Apr;78(2):201-205

Unité d'immunologie, CHU de Blida, Algérie, Département de médecine, Faculté de médecine, Université de Blida 1, Algérie.

Anti-citrullinated cyclic peptide antibodies (ACPA) were initially considered very specific for the diagnosis of rheumatoid arthritis (RA), and can predict the prognosis of the disease. However, these antibodies can be detected in other autoimmune diseases, including systemic lupus erythematosus (SLE), the most common manifestation of which is inflammatory arthritis, which is often found in early-stage rheumatoid arthritis. The aim of our study is to evaluate the prevalence of ACPA antibodies and to analyze the profiles of their associations with autoantibodies specific to lupus, in order to look for a possible rhupus overlap syndrome in our patients. Read More

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http://dx.doi.org/10.1684/abc.2020.1518DOI Listing

Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany.

Arthritis Res Ther 2020 04 15;22(1):81. Epub 2020 Apr 15.

German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany.

Background: To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome.

Methods: Prospective study of the National Paediatric Rheumatological Database (NPRD) including its uveitis add-on module from the years 2002 to 2016. Cross-sectional data from the years 2002 to 2016 were analyzed. Read More

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http://dx.doi.org/10.1186/s13075-020-02166-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161187PMC

Peripheral Blood Lymphocyte Phenotype Differentiates Secondary Antibody Deficiency in Rheumatic Disease from Primary Antibody Deficiency.

J Clin Med 2020 Apr 7;9(4). Epub 2020 Apr 7.

Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany.

The phenotype of primary immunodeficiency disorders (PID), and especially common variable immunodeficiency (CVID), may be dominated by symptoms of autoimmune disorders. Furthermore, autoimmunity may be the first manifestation of PID, frequently preceding infections and the diagnosis of hypogammaglobulinemia, which occurs later on. In this case, distinguishing PID from hypogammaglobulinemia secondary to anti-inflammatory treatment of autoimmunity may become challenging. Read More

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http://dx.doi.org/10.3390/jcm9041049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230453PMC

A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations.

Arthritis Res Ther 2020 02 12;22(1):26. Epub 2020 Feb 12.

Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.

Background: C-reactive protein (CRP) is often normal in patients with psoriatic disease. Herein, we aimed to define markers of systemic inflammation in patients with monomorphic and polymorphic psoriatic skin, entheseal, and joint disease.

Methods: Three-step approach: (i) selection of serum markers elevated in psoriatic arthritis compared healthy controls from a panel of 10 different markers reflecting the pathophysiology of psoriatic disease; (ii) testing of these selected markers as well as C-reactive protein (CRP) in a larger cohort of 210 individuals- 105 healthy controls and 105 patients with psoriatic disease with either monomorphic skin (S), entheseal (E) or joint (A) involvement or polymorphic disease with various combinations of skin, entheseal and joint disease (SE, SA, EA, SEA); (iii) testing whether tumor necrosis factor (TNF) and interleukin (IL)-17 inhibitor therapy normalizes these markers. Read More

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http://dx.doi.org/10.1186/s13075-020-2111-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017480PMC
February 2020

Changes of NADH Fluorescence from the Skin of Patients with Systemic Lupus Erythematosus.

Biomed Res Int 2019 24;2019:5897487. Epub 2019 Dec 24.

Department of Dermatology and Venereology, Medical University of Lodz, Poland 90-647 Lodz, Plac J. Hallera 1/6, Łódź, Poland.

Introduction: The blood circulation of the skin is an accessible and representative vascular bed for examining the mechanisms of microcirculatory function. Endothelial function is impaired in systemic lupus erythematosus (SLE), which implies disorders in cell metabolism dependent on blood circulation; however, noninvasive monitoring of metabolism at the tissue and cell level is absent in daily clinical practice.

Objective: The aim of the study was to examine changes of NADH fluorescence from the epidermis of a forearm measured with the flow mediated skin fluorescence (FMSF) technique in patients with SLE and to investigate whether they are associated with clinical manifestation of the disease. Read More

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http://dx.doi.org/10.1155/2019/5897487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942734PMC

Periodontitis is associated with disease severity and anti-double stranded DNA antibody and interferon-gamma levels in patients with systemic lupus erythematosus.

J Taibah Univ Med Sci 2019 Dec 21;14(6):560-565. Epub 2019 Oct 21.

Department of Pathology Clinic, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.

Objectives: To analyse the correlation between periodontitis severity and disease activity, anti-double stranded DNA (anti-dsDNA) antibody, and interferon-gamma (IFN-γ) levels in patients with systemic lupus erythematous (SLE).

Methods: We selected 61 patients with SLE (age 18-55 years) selected from a hospital in Malang, Indonesia. Clinical examination and laboratory tests were performed to assess disease activity. Read More

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http://dx.doi.org/10.1016/j.jtumed.2019.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940663PMC
December 2019

Adult-onset Still's disease as a cutaneous marker of systemic disease.

Clin Dermatol 2019 Nov - Dec;37(6):668-674. Epub 2019 Aug 1.

Univeristy Clinic of Rheumatology, Ss Cyriland Methodius University, Skopje, Macedonia.

Adult-onset Still's disease (AOSD) is a rare, systemic, inflammatory disorder characterized by spiking fevers, an evanescent eruption, arthritis, and multiorgan involvement. The disease has been recently classified as a polygenic autoinflammatory disorder at the "crossroads" of autoinflammatory and autoimmune diseases. The highly characteristic salmon-colored eruption is a cutaneous manifestation of a generalized inflammatory reaction and an important diagnostic criterion. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.034DOI Listing

Juvenile idiopathic arthritis-associated uveitis.

Clin Immunol 2020 Feb 9;211:108322. Epub 2019 Dec 9.

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK; Translational Health Sciences, University of Bristol, Bristol, UK. Electronic address:

Juvenile idiopathic arthritis (JIA) is the commonest rheumatic disease in children and JIA-associated uveitis its most frequent extra-articular manifestation. The uveitis is potentially sight-threatening and so carries a considerable risk of morbidity. The commonest form of uveitis seen in JIA is chronic anterior uveitis which is almost always asymptomatic in the initial stages. Read More

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http://dx.doi.org/10.1016/j.clim.2019.108322DOI Listing
February 2020

An unusual cause of acute ischemic stroke: Adult Onset Still's Disease.

J Thromb Thrombolysis 2020 Jan;49(1):141-144

Division of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.

Adult Onset Still's Disease (AOSD) is a systemic inflammatory disease of unknown aetiology. The usual manifestations of AOSD are spiking fevers, arthritis, and an evanescent salmon-pink rash, with neurological manifestations occasionally described. Stroke is a rare manifestation of AOSD and the exact mechanism for stroke in AOSD remains unknown, although it has been hypothesized to be secondary to thrombocytosis or vasculitis. Read More

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http://dx.doi.org/10.1007/s11239-019-02006-5DOI Listing
January 2020

The eye in spondyloarthritis.

Semin Arthritis Rheum 2019 12;49(3S):S29-S31

Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, United States; Legacy Devers Eye Institute, Suite 200, Portland, OR 97210, United States. Electronic address:

Acute anterior uveitis is the most common extra-articular clinical manifestation of spondyloarthropathy. Rheumatologists should be aware of uveitis, know how it presents, understand the differential diagnosis of uveitis and arthritis, and be familiar with the role of systemic medications in the treatment or prevention of uveitis. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981236PMC
December 2019

Interstitial Lung Disease as the Initial Manifestation of Rheumatoid Arthritis: A Case Report and Review of the Literature.

Am J Med Case Rep 2019 28;7(12):342-347. Epub 2019 Oct 28.

Department of Internal Medicine, Downstate Medical Center, State University of New York, Brooklyn, New York, United States 11203.

Background: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disorder that primarily affects synovial joints. Approximately 18-41% of patients with RA develop extra-articular manifestations [1]. However, extra-articular manifestations preceding or occurring without articular symptoms in RA have rarely been reported. Read More

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http://dx.doi.org/10.12691/ajmcr-7-12-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863351PMC
October 2019

Clinical and laboratory features, treatment, and outcomes of macrophage activation syndrome in 80 children: a multi-center study in China.

World J Pediatr 2020 Feb 14;16(1):89-98. Epub 2019 Oct 14.

Department of Rheumatology Immunology and Allergy, Children's Hospital, Zhejiang University School of Medicine, 57 Zhugan Lane, Hangzhou, 310003, China.

Background: Macrophage activation syndrome (MAS) is a major cause of morbidity and mortality in pediatric rheumatology. We aimed to further understand the clinical features, treatment, and outcome of MAS in China.

Methods: A multi-center cohort study was performed in seven hospitals in China from 2012 to 2018. Read More

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http://dx.doi.org/10.1007/s12519-019-00256-0DOI Listing
February 2020
2 Reads

[Late-onset sjögren's syndrom].

Wiad Lek 2019 ;72(9 cz 1):1687-1690

Klinika Reumatologii i Układowych Chorób Tkanki Łącznej, Uniwersytet Medyczny w Lublinie, Lublin, Polska.

Sjögren's syndrome is a systemic autoimmune disease characterized by exocrine glands damage, resulting in the development of dry eyes and dry mouth, as well as extraglandular manifestation. It usually starts between the ages of 30 and 50. Late-onset Sjögren's syndrome should be considered as a disease that appears after age 65, but the literature also reports of the age 50, 60, or even 70. Read More

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October 2019
1 Read

Early-onset granulomatous arthritis, uveitis and skin rash: characterization of skin involvement in Blau syndrome.

J Eur Acad Dermatol Venereol 2020 Feb 29;34(2):340-348. Epub 2019 Oct 29.

Department of General Pediatrics, Paediatric Internal Medicine, Rheumatology and Infectious Diseases, National Reference Centre for Rare Paediatric Inflammatory Rheumatisms and Systemic Auto-immune diseases RAISE, Robert Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Background: Blau syndrome (BS) is a rare monogenic autoinflammatory disease caused by NOD2 mutations. BS classically presents in early childhood as a triad of granulomatous polyarthritis, uveitis and skin involvement. Joint and ocular involvement have been characterized by several cohort studies but only very little data are available on skin lesions. Read More

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http://dx.doi.org/10.1111/jdv.15963DOI Listing
February 2020
2 Reads

Spontaneous Model of Sjögren's Syndrome in NOD Mice.

Curr Protoc Pharmacol 2019 09;86(1):e65

Incyte Corporation, Wilmington, Delaware.

The non-obese diabetic (NOD) mouse model is the most widely described and validated method for investigating human primary Sjögren's syndrome (SS) and represents a useful model for translational studies. However, the systemic disease manifestation in NOD mice is sensitive to the housing environment, as stress modulates the immune system, so it is essential to confirm that readouts are robust, reproducible, and sensitive to known clinical treatments. This protocol describes the establishment of the spontaneous NOD model of SS and underscores the necessity of model validation to ensure that the housing environment is compatible. Read More

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http://dx.doi.org/10.1002/cpph.65DOI Listing
September 2019
1 Read

Prevalence and associated factors of subclinical atherosclerosis in rheumatoid arthritis at the university hospital of Kinshasa.

BMC Rheumatol 2019 9;3:37. Epub 2019 Sep 9.

Rheumatology Unit, Department of internal medicine, University Hospital of Kinshasa, Kinshasa, Democratic Republic of Congo.

Background: Rheumatoid arthritis (RA) is associated with a 5 to 10 years reduction in life expectancy due to premature atherosclerosis. This reduction is the consequence of traditional cardiovascular risk factors (TCRF) as well as systemic inflammation. The aim of the present study was to describe the prevalence and factors associated with subclinical atherosclerosis in RA at the University Hospital of Kinshasa (UHK). Read More

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http://dx.doi.org/10.1186/s41927-019-0085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732832PMC
September 2019
1 Read

Systemic sclerosis.

Br J Hosp Med (Lond) 2019 Sep;80(9):530-536

Professor of Rheumatology, Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester.

Systemic sclerosis is a complex autoimmune connective tissue disease which carries a significant burden of disease-related morbidity including potentially life-threatening complications. Systemic sclerosis can affect all the major organs and therefore, although the disease is uncommon, many hospital-based specialists are involved in patient care. Vascular disease (e. Read More

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http://dx.doi.org/10.12968/hmed.2019.80.9.530DOI Listing
September 2019
3 Reads

AA amyloidosis secondary to adult onset Still's disease: About 19 cases.

Semin Arthritis Rheum 2020 02 10;50(1):156-165. Epub 2019 Aug 10.

Sorbonne Université, AP-HP, Hôpital Tenon, Service de médecine interne, Centre de référence des maladies auto-inflammatoires et des amyloses d'origine inflammatoire (CEREMAIA), F-75020, Paris, France. Electronic address:

Objective: Adult onset Still's disease (AOSD) is an inflammatory disorder characterized by high spiking fever, evanescent rash, polyarthritis, and many other systemic manifestations. Recurrent or persistent disease can lead to AA amyloidosis (AAA). Our objectives were to present 3 French cases and perform a systematic review of the literature, in order to determine the prevalence, characteristics, predisposing factors, and therapeutic response of AOSD-related AAA. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.08.005DOI Listing
February 2020
2 Reads

Progressive fibrosing interstitial lung disease associated with systemic autoimmune diseases.

Clin Rheumatol 2019 Oct 19;38(10):2673-2681. Epub 2019 Aug 19.

University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054, Erlangen, Germany.

Interstitial lung disease (ILD) is a common manifestation of systemic autoimmune diseases and a leading cause of death in these patients. A proportion of patients with autoimmune ILDs develop a progressive fibrosing form of ILD, characterized by increasing fibrosis on high-resolution computed tomography, worsening of lung function, and early mortality. Autoimmune disease-related ILDs have a variable clinical course and not all patients will require treatment, but all patients should be monitored for signs of progression. Read More

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http://dx.doi.org/10.1007/s10067-019-04720-0DOI Listing
October 2019
2 Reads

Types of pain and their psychosocial impact in women with rheumatoid arthritis.

Womens Midlife Health 2019 9;5. Epub 2019 Aug 9.

1Department of Rheumatology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Forchh 701N, Bronx, NY 10461 USA.

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease predominantly affecting middle-aged women. Very commonly, pain is a manifestation of active disease and because untreated RA can result in joint deformities, the current evaluation of pain has largely focused on inflammation. In addition, treatment has centered on the premise of reducing disease activity with the hopes of halting worsening damage, preventing future deformities, and ultimately providing pain relief for the patient. Read More

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https://womensmidlifehealthjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s40695-019-0047-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688257PMC
August 2019
4 Reads

Intermetatarsal bursitis as first disease manifestation in different rheumatological disorders and related MR-imaging findings.

Rheumatol Int 2019 Dec 18;39(12):2129-2136. Epub 2019 Jul 18.

Department of Radiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Metatarsalgia defined as pain at the plantar aspect of the forefoot. Intermetatarsal bursitis is considered one potential soft-tissue cause of metatarsalgia that is presumably under-estimated, under-investigated, and, consequently, often misdiagnosed. To assess the role of MRI in the elucidation of the cause of metatarsalgia in patients with different autoimmune disorders presenting primarily with this symptom and to present the accompanying clinical and radiological findings of intermetatarsal bursitis. Read More

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http://dx.doi.org/10.1007/s00296-019-04381-xDOI Listing
December 2019
6 Reads

The levels of CXCL12 and its receptor, CXCR4, as a biomarker of disease activity and cutaneous manifestation in adult-onset Still's disease.

Clin Exp Rheumatol 2019 Nov-Dec;37 Suppl 121(6):67-73. Epub 2019 Jun 28.

Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea.

Objectives: This study evaluated the SDF-1/CXCL12 and soluble CXCR4 (sCXCR4) levels, and investigated their clinical relevance in adult-onset Still's disease (AOSD).

Methods: Forty-two AOSD patients and 30 healthy controls (HC) were enrolled for serum sampling. Expression levels of CXCL12 and CXCR4 in skin biopsy materials of 40 AOSD patients, 10 patients with eczema, or 10 psoriasis, and 10 HC skin were evaluated with immunohistochemistry. Read More

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January 2020

Progressive multifocal leukoencephalopathy in a patient with systemic lupus erythematosus: Clues to early diagnosis.

J Clin Neurosci 2019 Sep 2;67:261-263. Epub 2019 Jul 2.

Neuroimmunology Clinic, Concord Hospital, University of Sydney, NSW, Australia; Brain and Mind Centre, University of Sydney, NSW, Australia. Electronic address:

A case of progressive multifocal leukoencephalopathy (PML) occurring on low dose immunosuppression for systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS) is presented. Neurologic changes in patients with SLE or SS should not be assumed to be a disease manifestation. Importantly, serious opportunistic infections such as PML can occur in minimally immunosuppressed rheumatic patients. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.06.030DOI Listing
September 2019
4 Reads

An update on the modern management of paediatric uveitis.

Br J Ophthalmol 2019 12 4;103(12):1685-1689. Epub 2019 Jul 4.

Medical School, University of Nottingham, Nottingham, UK.

Uveitis in children and young people (CYP) is often painless, chronic and persistent. It is an often silent blinding condition. Uveitis can be isolated or develop as a manifestation of a systemic disease. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2019-3142
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http://dx.doi.org/10.1136/bjophthalmol-2019-314212DOI Listing
December 2019
4 Reads

Bilateral brachial synovial cysts in systemic juvenile idiopathic arthritis: Case report and literature review.

Authors:
Qi Zheng Meiping Lu

Int J Rheum Dis 2019 Aug 27;22(8):1578-1581. Epub 2019 Jun 27.

Department of Rheumatology, Immunology and Allergy, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Aim: To review the clinical features of brachial synovial cyst.

Method: A case of bilateral brachial synovial cysts is described in a child suffering from systemic juvenile idiopathic arthritis during a relapse. Magnetic resonance imaging and ultrasonography were conducted to further evaluate the nature of the cysts. Read More

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http://doi.wiley.com/10.1111/1756-185X.13618
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http://dx.doi.org/10.1111/1756-185X.13618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771648PMC
August 2019
7 Reads

Diagnostic accuracy of a velcro sound detector (VECTOR) for interstitial lung disease in rheumatoid arthritis patients: the InSPIRAtE validation study (INterStitial pneumonia in rheumatoid ArThritis with an electronic device).

BMC Pulm Med 2019 Jun 20;19(1):111. Epub 2019 Jun 20.

Rheumatology Unit, Azienda Policlinico di Modena, University of Modena and Reggio Emilia, Via del Pozzo, 71 41121, Modena, Italy.

Background: Interstitial lung disease (ILD) is a severe systemic manifestation of rheumatoid arthritis (RA). High-resolution computed tomography (HRCT) represents the gold standard for the diagnosis of ILD, but its routine use for screening programs is not advisable because of both high cost and X-ray exposure. Velcro crackles at lung auscultation occur very early in the course of interstitial pneumonia, and their detection is an indication for HRCT. Read More

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http://dx.doi.org/10.1186/s12890-019-0875-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587236PMC
June 2019
18 Reads

GADD45a and GADD45b Genes in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients.

J Clin Med 2019 Jun 5;8(6). Epub 2019 Jun 5.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Background: GADD45 genes are stress sensors in response to cellular stress response, activated signal pathways leading to the stimulation of inflammatory cytokines. This study is to examine the associations of GADD45a and GADD45b genes with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients.

Methods: 230 patients of RA, 140 patients of SLE, and 191 healthy controls were enrolled. Read More

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http://dx.doi.org/10.3390/jcm8060801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617344PMC
June 2019
7 Reads

Acute exacerbation of interstitial lung diseases secondary to systemic rheumatic diseases: a prospective study and review of the literature.

J Thorac Dis 2019 Apr;11(4):1621-1628

Rheumatology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.

Acute exacerbation (AE) is a possible manifestation of interstitial lung diseases (ILD) associated to very high mortality. It's defined as clinically significant respiratory deterioration with evidence of new widespread alveolar abnormalities on computed tomography scan. AE is better described in idiopathic pulmonary fibrosis (IPF) but also reported in ILD secondary to connective tissue diseases (CTD) and vasculitis. Read More

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http://jtd.amegroups.com/article/view/28089/20906
Publisher Site
http://dx.doi.org/10.21037/jtd.2019.03.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531687PMC
April 2019
7 Reads

Bilateral facial paralysis as a rare neurological manifestation of primary Sjögren's syndrome: case-based review.

Rheumatol Int 2019 Sep 7;39(9):1651-1654. Epub 2019 Jun 7.

Department of Neurology, First Hospital, Shanxi Medical University, No. 85, Jiefang Nan Street, Taiyuan, China.

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder associated with a variety of systemic presentations. Varied neurological dysfunctions of newly diagnosed adult patients with pSS have been observed in recent years. We aimed to describe a rare case of acute bilateral facial paralysis diagnosed with pSS for the first time and review the previous studies including similar cases. Read More

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http://dx.doi.org/10.1007/s00296-019-04339-zDOI Listing
September 2019
17 Reads
1.627 Impact Factor

Computed Tomographic Imaging in Connective Tissue Diseases.

Semin Respir Crit Care Med 2019 04 28;40(2):159-172. Epub 2019 May 28.

Department of Radiology, Royal Brompton Hospital, London, United Kingdom.

Pulmonary disease represents a significant extra-articular manifestation in the majority of connective tissue diseases (CTDs). The identification, classification, and staging of pulmonary involvement are centrally important to the management of patients, aiding the prognostication of disease behavior and treatment decisions. We present a review of the high-resolution computed tomographic pulmonary features of CTD in the lung and their significance to the reporting radiologist. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685165
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http://dx.doi.org/10.1055/s-0039-1685165DOI Listing
April 2019
13 Reads

Leprosy presenting as remitting seronegative symmetrical synovitis with pitting oedema syndrome - a case report.

BMC Infect Dis 2019 May 22;19(1):455. Epub 2019 May 22.

Department of Rheumatology, Centro Hospitalar Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.

Background: Leprosy typically manifests with skin and peripheral nerve involvement. Musculoskeletal complaints are the third most common, and can be the sole presenting manifestation. They range from arthralgia/arthritis in reactional states to full mimics of systemic rheumatic diseases. Read More

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http://dx.doi.org/10.1186/s12879-019-4098-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530132PMC
May 2019
8 Reads

Myelopathy associated with mixed connective tissue disease: clinical manifestation, diagnosis, treatment, and prognosis.

Neurol Sci 2019 Sep 21;40(9):1785-1797. Epub 2019 May 21.

Department of Neurology and Neuroscience center, First Hospital of Jilin University, 72 Xinming Street, Chaoyang District, Changchun, 130021, Jilin Province, People's Republic of China.

Mixed connective tissue disease (MCTD) is a chronic autoimmune disease, which has a broad range of clinical manifestations shared by systemic lupus erythematosus, systemic sclerosis, polymyositis/dermatomyositis, and rheumatoid arthritis. MCTD is featured with high serum titers of anti-ribonucleoprotein antibodies and multiple system involvement. Its spinal cord involvement mainly manifests as transverse myelopathy (TM) and longitudinal extensive transverse myelopathy (LETM). Read More

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http://dx.doi.org/10.1007/s10072-019-03935-yDOI Listing
September 2019
8 Reads

Systemic Vasculitis Associated With Immune Check Point Inhibition: Analysis and Review.

Curr Rheumatol Rep 2019 05 21;21(6):28. Epub 2019 May 21.

Division of Rheumatology, University of Mississippi Medical Center, 2500 N State St., Jackson, MS, 39216, USA.

Purpose Of Review: Immunotherapy with immune checkpoint inhibitors (ICIs) has become a well-established modality to treat a number of different malignancies, especially in cases with advanced stages and/or recurrent diseases. These agents have been associated with development of a variety of autoimmune disorders as immune-related adverse events (IRAEs or irAEs). This review focuses on development of vasculitis with use of ICI. Read More

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http://dx.doi.org/10.1007/s11926-019-0828-7DOI Listing
May 2019
4 Reads

Cognitive Dysfunction in Systemic Lupus Erythematosus: A Case for Initiating Trials.

Arthritis Rheumatol 2019 09 7;71(9):1413-1425. Epub 2019 Aug 7.

Northwell Health, New York, New York.

Cognitive dysfunction (CD) is an insidious and underdiagnosed manifestation of systemic lupus erythematosus (SLE) that has a considerable impact on quality of life, which can be devastating. Given the inconsistencies in the modes of assessment and the difficulties in attribution to SLE, the reported prevalence of CD ranges from 5% to 80%. Although clinical studies of SLE-related CD have been hampered by heterogeneous subject populations and a lack of sensitive and standardized cognitive tests or other validated objective biomarkers for CD, there are, nonetheless, strong data from mouse models and from the clinical arena that show CD is related to known disease mechanisms. Read More

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http://dx.doi.org/10.1002/art.40933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716992PMC
September 2019
5 Reads

Hip osteoarticular complication due to delay in diagnosis and treatment of brucellar hip arthritis: two cases report.

Authors:
Jie He Qiang Zhang

BMC Infect Dis 2019 May 14;19(1):412. Epub 2019 May 14.

Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.

Background: Brucellosis is a systemic infectious disease frequently associated with osteoarticular involvement. While sacroiliitis is a common manifestation of brucellosis, septic osteoarthritis is less frequent. Here, we report two cases of septic osteoarthritis caused by Brucella melitensis. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-4045-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518787PMC
May 2019
20 Reads

Areas of agreement in the management of childhood non-infectious chronic anterior uveitis in the UK.

Br J Ophthalmol 2020 01 2;104(1):11-16. Epub 2019 May 2.

Great Ormond Street Hospital For Children NHS Foundation Trust, London, UK.

Background/aims: There is a paucity of high-level evidence to support the management of childhood uveitis, particularly for those children without juvenile idiopathic arthritis uveitis (JIA). We undertook a modified Delphi consensus exercise to identify agreement in the management of chronic anterior uveitis (CAU), the most common manifestation of childhood disease.

Methods: A four-round, two-panel process was undertaken between June and December 2017. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313789DOI Listing
January 2020
21 Reads

Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Mutation.

J Immunol 2019 06 24;202(11):3161-3172. Epub 2019 Apr 24.

Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

A defect in TCR-proximal signaling is a major characteristic of CD4 T cells in systemic lupus erythematosus; however, it is not fully known how defects in TCR signaling lead to lupus-like systemic autoimmunity characterized by germinal center development and autoantibody production against nuclear Ags. In this study, we show that SKG mice, which develop autoimmune arthritis in a BALB/c background due to defective TCR signaling by a mutation, develop lupus-like systemic autoimmune disease in the C57BL/6 (B6) background (B6SKG mice). B6SKG mice showed multiorgan inflammation with immune complex deposition and anti-dsDNA Ab production. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801159
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http://dx.doi.org/10.4049/jimmunol.1801159DOI Listing
June 2019
30 Reads

The Epidemiology of Antiphospholipid Syndrome: A Population-Based Study.

Arthritis Rheumatol 2019 09 1;71(9):1545-1552. Epub 2019 Aug 1.

Mayo Clinic, Rochester, Minnesota.

Objective: To estimate the annual incidence and prevalence of and frequency of mortality associated with antiphospholipid syndrome (APS).

Methods: An inception cohort of patients with incident APS in 2000-2015 from a geographically well-defined population was identified based on comprehensive individual medical records review. All cases met the 2006 Sydney criteria for APS (primary definition) or had a diagnosis of APS confirmed by physician consensus (secondary definition). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/art.40901
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http://dx.doi.org/10.1002/art.40901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717037PMC
September 2019
17 Reads

Systemic treatment with resveratrol alleviates adjuvant arthritis-interstitial lung disease in rats via modulation of JAK/STAT/RANKL signaling pathway.

Pulm Pharmacol Ther 2019 06 28;56:69-74. Epub 2019 Mar 28.

The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, 214000, Jiangsu, China. Electronic address:

Interstitial lung disease (ILD) is the most common pulmonary manifestation of Rheumatoid arthritis (RA) lung disease. The mechanism of RA-ILD remains obscure and more effective treatments are still needed. Resveratrol (RSV) a phytoalexin found with anti-inflammation and antioxidant activity. Read More

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http://dx.doi.org/10.1016/j.pupt.2019.03.011DOI Listing
June 2019
9 Reads

[RABBIT-SpA: a new disease register for axial spondyloarthritis and psoriatic arthritis].

Z Rheumatol 2020 Mar;79(2):135-142

Programmbereich Epidemiologie, Deutsches Rheuma-Forschungszentrum Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Background: The treatment of axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) has changed enormously in recent years due to market authorization of a number of new biologicals with different modes of action and the increasing use of biosimilars. Real-world data on long-term safety and efficacy under routine daily conditions is not yet sufficient. Therefore, the German Rheumatism Research Center has initiated a new cohort study covering axSpA and PsA. Read More

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http://dx.doi.org/10.1007/s00393-019-0613-zDOI Listing
March 2020
7 Reads

[Improvement of prognosis by timely treatment : Requirement: initial presentation within 6 weeks].

Z Rheumatol 2019 Jun;78(5):396-403

Klinik für Rheumatologie und Klinische Immunologie, Immanuel Krankenhaus Berlin, Berlin, Deutschland.

Rheumatoid arthritis (RA) is one of the most frequent chronic inflammatory rheumatic diseases and when untreated leads to chronic tissue destruction and increased mortality. Due to innovative systemic treatment strategies established over the last 20-25 years, the prognosis has considerably improved in terms of disease and socioeconomic burdens, symptoms, long-term prognosis, ability to work and mortality; however, as a rule a prerequisite is long-term and continuous treatment. A medicinal cure of RA is still not in view. Read More

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http://link.springer.com/10.1007/s00393-019-0607-x
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http://dx.doi.org/10.1007/s00393-019-0607-xDOI Listing
June 2019
28 Reads

Clinical Experience of Sirolimus Regarding Efficacy and Safety in Systemic Lupus Erythematosus.

Front Pharmacol 2019 6;10:82. Epub 2019 Feb 6.

Rheumatology/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

New treatment options constitute unmet needs for patients diagnosed with systemic lupus erythematosus (SLE). Inhibition of the mammalian target of rapamycin (mTOR) pathway by sirolimus, a drug approved and in clinical use to prevent transplant rejection, has shown promising effects in lupus animal models as well as in patients with both antiphospholipid syndrome and SLE. Sirolimus inhibits antigen-induced T cell proliferation and increases the number of circulating regulatory T cells. Read More

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http://dx.doi.org/10.3389/fphar.2019.00082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372521PMC
February 2019
9 Reads

The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis.

Ci Ji Yi Xue Za Zhi 2019 Jan-Mar;31(1):5-10

Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.

Rheumatoid arthritis (RA) is a common systemic autoimmune disease. Its major manifestation is persistent joint inflammation, which can lead to bone destruction and severe disability. The immunopathogenesis of RA is very complex, involving both innate and adaptive immune systems. Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_116_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334572PMC
January 2019
8 Reads

Patterns of peripheral neuropathy in Sjogren's syndrome in a tertiary care hospital from South India.

Neurol India 2019 Jan-Feb;67(Supplement):S94-S99

Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Introduction: Sjogren's syndrome (SS) is a systemic autoimmune disease that apart from involving the exocrine glands can affect any organ. Involvement of the peripheral nervous system results in a wide spectrum of neuropathic manifestations.

Objective: To evaluate the clinico-electrophysiological patterns as well as pathological characteristics of neuropathy in SS patients presenting to a neuromuscular clinic in a tertiary hospital from South India. Read More

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http://dx.doi.org/10.4103/0028-3886.250714DOI Listing
December 2019
35 Reads
1.084 Impact Factor