807 results match your criteria Arthritis as a Manifestation of Systemic Disease


Anterior and posterior uveitis associated with juvenile idiopathic arthritis -case report.

Rom J Ophthalmol 2022 Apr-Jun;66(2):185-190

Department of Ophthalmology "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania; Department of Ophthalmology, County Emergency Hospital, Cluj-Napoca, Romania.

Anterior uveitis is the most common extra-articular manifestation in children diagnosed with Juvenile idiopathic arthritis (JIA). It is typically a non-granulomatous, chronic, and asymptomatic uveitis. The lack of acute symptoms often delays the diagnosis with the incidence of severe ocular complications. Read More

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Treating Autoimmune-Related Interstitial Lung Disease With B Cell Depletion.

Front Med (Lausanne) 2022 30;9:937561. Epub 2022 Jun 30.

Division of Rheumatology, Patras University Hospital, Patras, Greece.

Autoimmune rheumatic diseases may affect vital organs with lung involvement being severe and difficult to treat manifestation. Systemic sclerosis (SSc) commonly affects the lung in the form of interstitial lung disease (ILD). ILD may be also seen in patients with rheumatoid arthritis (RA), Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), inflammatory myositis (IM), antisynthetase syndrome (AS), and the ANCA-associated vasculitides (AAV). Read More

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Diagnosis of juvenile idiopathic arthritis with asymptomatic involvement of the temporomandibular joint: A case report.

Spec Care Dentist 2022 Jul 13. Epub 2022 Jul 13.

Department of Stomatology, School of Dentistry, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.

Juvenile idiopathic arthritis (JIA) is a broad term that describes a group of heterogeneous rheumatologic diseases, mainly characterized by inflammation in the joints of children and young people up to 16 years of age. Its etiology is still not well understood and the diagnosis, essentially clinical, begins with the exclusion of other joint diseases. When the disease affects the temporomandibular joint, diagnosis is a challenge, as many patients are asymptomatic. Read More

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PI3 kinase delta deficiency protects from anti-myeloperoxidase vasculitis.

Arthritis Rheumatol 2022 Jul 11. Epub 2022 Jul 11.

School of Immunology and Microbial Sciences, King's College London, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.

Objectives: Anti-neutrophil cytoplasmic antibody vasculitis is a systemic autoimmune disease in which glomerulonephritis is an important manifestation. Antibodies against myeloperoxidase or proteinase 3 are thought to be important in pathogenesis. Phosphoinositide 3-kinase delta mediates a number of effects in lymphocytes but its role in myeloid cell responses is less clear. Read More

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TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review.

Autoimmun Rev 2022 Aug 6;21(8):103137. Epub 2022 Jul 6.

Department of Internal Medicine, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France; CIRI - Centre International de Recherche en Infectiologie, Team GIMAP, Université Jean Monnet, Unversité Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, F42023 Saint-Etienne, France; CIC 1408 Inserm, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France. Electronic address:

Background: Sjögren's syndrome (SjS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands associated with sicca syndrome. TAFRO syndrome is a systemic inflammatory disease of unknown cause, characterized by Thrombocytopenia, Anasarca, Fever, Reticulin fibrosis, Renal dysfunction and Organomegaly, first reported in 2010 in Japanese patients. Despite their rarity, both conditions have been concurrently reported in several patients during the recent years, hence questioning the existence of shared or related features. Read More

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[Nephrotic Syndrome Caused by AA Amyloidosis Secondary to Unicentric Castleman's Disease:Report of One Case].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2022 Jun;44(3):540-544

Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

AA amyloidosis is a rare systemic complication caused commonly by chronic inflammatory arthritis,periodic fever disease,vasculitis,tumors,etc.Castleman's disease is an uncommon cause of AA amyloidosis.Here,we reported a case of unicentric Castleman's disease-induced AA amyloidosis with nephrotic syndrome as the main manifestation. Read More

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Combined Ophthalmology and Rheumatology Evaluation in Systemic Autoimmune Diseases with Ocular Involvement: A Third Level Reference Center in Mexico.

Ocul Immunol Inflamm 2022 Jun 27:1-7. Epub 2022 Jun 27.

Inflammatory Eye Disease Clinic, Asociación Para Evitar la Ceguera en México, I.A.P, Mexico City, Mexico.

Aim: A cross-sectional descriptive study to determine the frequency of ocular manifestations associated with systemic autoimmune diseases in a third-level hospital in Mexico.

Methods: Records from 2014 to 2017 at the Inflammatory Eye Disease Clinic of the Asociación Para Evitar la Cegueraen México were examined by both an ophthalmologist and a rheumatologist on the same day. Diagnosis was achieved from initial ocular manifestations with later systemic assessment. Read More

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Novel Biomarkers, Diagnostic and Therapeutic Approach in Rheumatoid Arthritis Interstitial Lung Disease-A Narrative Review.

Biomedicines 2022 Jun 9;10(6). Epub 2022 Jun 9.

Department of Rheumatology and Internal Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Rheumatoid arthritis (RA) is considered a systemic inflammatory disease marked by polyarthritis which affects the joints symmetrically, leading to progressive damage of the bone structure and eventually joint deformity. Lung involvement is the most prevalent extra-articular feature of RA, affecting 10-60% of patients with this disease. In this review, we aim to discuss the patterns of RA interstitial lung disease (ILD), the molecular mechanisms involved in the pathogenesis of ILD in RA, and also the therapeutic challenges in this particular extra-articular manifestation. Read More

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Tendons and Tendon Sheaths of the Hand - An Update on MRI.

Rofo 2022 Jun 15. Epub 2022 Jun 15.

Department of Radiology, University Hospital Wuerzburg, Germany.

Background:  The tendons of the hand run in close proximity to each other and within retinacular tunnels adjacent to articular joints, while forming intersections in characteristic locations. The enclosing tendon sheaths are often sites of systemic or infectious inflammation.

Method:  This review article outlines the different entities of tendon and tendon sheath pathology and their manifestation in the hands. Read More

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Lupus Cerebritis as a Rare Neuropsychiatric Manifestation of Systemic Lupus Erythematosus.

Cureus 2022 May 13;14(5):e24973. Epub 2022 May 13.

General Surgery, West Suburban Medical Center, Chicago, USA.

Mixed connective tissue disease (MCTD) is a rare autoimmune condition that shows an overlap of at least two connective tissue diseases (CTD) including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), scleroderma, Sjögren's syndrome, polymyositis, or dermatomyositis. From a laboratory standpoint, MCTD is associated with high titers of anti-U1-RNP antibodies, which makes it difficult to determine whether it is a variant of each of the respective CTDs or a different entity altogether. Our objective is to report the case of a patient with MCTD presenting with status epilepticus who was ultimately diagnosed with lupus cerebritis. Read More

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Nail Psoriasis.

Actas Dermosifiliogr 2022 May 2;113(5):481-490. Epub 2022 Feb 2.

Departamento de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.

Nail involvement in psoriasis is common. It is seen in up to 80% of patients with psoriatic lesions and may be the only manifestation in 6% of cases. Nail psoriasis is correlated with more severe disease, characterized by earlier onset and a higher risk of psoriatic arthritis. Read More

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Clinical characteristics and prognosis of patients with antiphospholipid antibodies based on cluster analysis: an 8-year cohort study.

Arthritis Res Ther 2022 06 11;24(1):140. Epub 2022 Jun 11.

Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by persistent antiphospholipid antibodies (aPLs) positivity with a wide manifestation spectrum. A risk stratification is needed for management guidance and prognosis assessment. We aimed to identify phenotypes among aPL-positive patients and assess the prognosis of each phenotype. Read More

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Increased Demand for Therapeutic Drugs in Pediatric Ulcerative Colitis Patients With Extraintestinal Manifestations.

Front Pediatr 2022 23;10:853019. Epub 2022 May 23.

Department of Pediatrics, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.

Background: Ulcerative colitis (UC) is a systemic inflammatory disease with a gut predominance, which may involve other organs. The presence of extraintestinal manifestation (EIM) is an important symptom for clinicians as it alters the treatment decisions. In this study, we aimed to evaluate the initial clinical presentation and disease severity of pediatric UC patients with EIMs. Read More

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Treatment approach to connective tissue disease-associated interstitial lung disease.

Curr Opin Pharmacol 2022 Aug 1;65:102245. Epub 2022 Jun 1.

University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA.

Interstitial lung disease (ILD) is a common manifestation in connective tissue diseases (CTD), such as rheumatoid arthritis (RA), systemic sclerosis (SSc), and inflammatory myositis (IM). ILD is associated with significant morbidity and mortality in nearly all CTD highlighting the critical need for effective treatment strategies in this patient population. In this review, we will summarize the approach to treatment when there is concern for CTD-ILD and highlight recent advancements in therapeutics within various forms of CTD-ILD. Read More

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The Efficacy and Safety of Pirfenidone Combined With Immunosuppressant Therapy in Connective Tissue Disease-Associated Interstitial Lung Disease: A 24-Week Prospective Controlled Cohort Study.

Front Med (Lausanne) 2022 12;9:871861. Epub 2022 May 12.

Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Objective: Interstitial lung disease (ILD) is a common manifestation of connective tissue disease (CTD) that manifests as several subtypes with significant differences in prognosis. It is necessary to evaluate the efficacy and safety of pirfenidone (PFD) combined with immunosuppressant (IS) in the treatment of CTD-ILD.

Methods: A total of 111 patients with CTD-ILD were enrolled, including those with systemic sclerosis (SSc), inflammatory myopathy (IIM), rheumatoid arthritis (RA), and other CTDs (such as systemic lupus erythematosus, primary Sjogren's syndrome, and undifferentiated CTD). Read More

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Cardiovascular Involvement in Sjögren's Syndrome.

Front Immunol 2022 6;13:879516. Epub 2022 May 6.

Rheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Sjögren Syndrome (SS) seems to be associated with a greater "overall risk" of cardiovascular (CV) and cerebrovascular events. Although not conventionally considered a feature of the disease, CV events represent a major burden in SS patients. CV risk is the consequence of a complex combination of multiple factors, including traditional risk factors and disease-related mechanisms. Read More

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Bone Health in Children with Rheumatic Disorders: Focus on Molecular Mechanisms, Diagnosis, and Management.

Int J Mol Sci 2022 May 20;23(10). Epub 2022 May 20.

Department of Pediatrics, University of Chieti, 66100 Chieti, Italy.

Bone is an extremely dynamic and adaptive tissue, whose metabolism and homeostasis is influenced by many different hormonal, mechanical, nutritional, immunological and pharmacological stimuli. Genetic factors significantly affect bone health, through their influence on bone cells function, cartilage quality, calcium and vitamin D homeostasis, sex hormone metabolism and pubertal timing. In addition, optimal nutrition and physical activity contribute to bone mass acquisition in the growing age. Read More

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Clinical Significance of Fecal Calprotectin for Evaluating Mucosal Inflammation with IgA Vasculitis.

JMA J 2022 Apr 25;5(2):277-279. Epub 2022 Mar 25.

Department of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan.

IgA vasculitis is the most common systemic small vasculitis in children. Its major clinical manifestations are palpable purpura, arthritis and arthralgias, gastrointestinal involvement, and renal manifestations. Regarding gastrointestinal manifestations, steroids are effective in reducing abdominal pain. Read More

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Gastric antral vascular ectasia in systemic sclerosis: a study of its epidemiology, disease characteristics and impact on survival.

Arthritis Res Ther 2022 05 10;24(1):103. Epub 2022 May 10.

Department of Medicine, The University of Melbourne at St Vincent's Hospital (Melbourne), 41 Victoria Parade, Fitzroy, Victoria, 3065, Australia.

Background: To describe the epidemiology, determinants and survival impact of gastric antral vascular ectasia (GAVE) in systemic sclerosis (SSc).

Methods: Consecutive SSc patients prospectively enrolled in the Australian Scleroderma Cohort Study (ASCS) were included. Univariable and multivariable logistic regression were used to determine the associations of GAVE with clinical manifestations and serological parameters. Read More

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Melatonin regulates the immune response and improves Sjögren's syndrome-like symptoms in NOD/Ltj Mice.

Biochem Pharmacol 2022 07 4;201:115073. Epub 2022 May 4.

Department of Stomatology, Zhongnan Hospital of Wuhan University, China. Electronic address:

Primary Sjögren's syndrome (pSS) is an autoimmune disease that primarily affects exocrine glands and is characterized by sicca syndrome and systemic manifestation. Mounting evidence indicates that circadian clocks are involved in the onset and progression of autoimmune diseases, including rheumatic arthritis, multiple sclerosis, and systemic lupus erythematosus. However, few studies have reported the expression of clock genes in pSS. Read More

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Early diagnosis and treatment of acute brucellosis knee arthritis complicated by acute osteomyelitis: two cases report.

BMC Infect Dis 2022 May 4;22(1):430. Epub 2022 May 4.

Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.

Background: Brucellosis is an endemic systemic infectious disease, the most common complication is bone and joint involvement. Sacroiliac joint and spinal joint are the most frequently involved sites in adults, but knee joint infection is rare, and acute infectious knee arthritis complicated by acute osteomyelitis is even extremely uncommon in adults. Here, we report two cases of acute septic knee arthritis complicated by acute osteomyelitis caused by Brucella melitensis (B. Read More

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Seroprevalence of SARS-CoV-2-specific antibodies and vaccination-related adverse events in systemic lupus erythematosus and rheumatoid arthritis.

Biomed Pharmacother 2022 Jun 26;150:112997. Epub 2022 Apr 26.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230016, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, 81 Meishan Road, Hefei 230016 Anhui, China. Electronic address:

Background: This study aimed to investigate the seroreactivity of Coronavirus disease 2019 (COVID-19) vaccination and its adverse events among systemic lupus erythematosus (SLE) patients, rheumatoid arthritis (RA) patients, and healthy controls (HCs).

Methods: A total of 60 SLE patients, 70 RA patients and 35 HCs, who received a complete inactivated COVID-19 vaccine (Vero cells) regimen, were recruited in the current study. Serum IgG and IgM antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were determined by using chemiluminescent microparticle immunoassay (CMIA). Read More

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Reactivation of juvenile idiopathic arthritis associated uveitis with posterior segment manifestations following anti-SARS-CoV-2 vaccination.

J Ophthalmic Inflamm Infect 2022 Apr 27;12(1):15. Epub 2022 Apr 27.

Department of Rheumatology, Vikram Hospital, Bangalore, India.

Background/purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in the pediatric population and anterior uveitis is its commonest extra-articular manifestation. Typically the uveitis presents as chronic anterior uveitis and there is limited literature of the posterior segment manifestations of the disease. Similar to other vaccines, anti-SARS-CoV-2 vaccination that began as an urgent measure to control the spread of the SARS-CoV-2 pandemic has not been without adverse events. Read More

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Autoantibodies against specific post-translationally modified proteins are present in patients with lupus and associate with major neuropsychiatric manifestations.

RMD Open 2022 04;8(1)

Immunology, Leiden University Medical Center, Leiden, The Netherlands

Background: Although autoantibodies are an important hallmark of systemic lupus erythematosus (SLE), most are not specific for SLE or any of its clinical manifestations. Autoantibodies against post-translationally modified (PTM) proteins have been studied extensively in rheumatoid arthritis and associate with disease progression. While PTMs have also been detected in patients with SLE, studies on anti-PTM antibodies remain scarce. Read More

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Clinical & Demographic Profile and Prevalence of Metabolic Syndrome Among Patients with Rheumatoid Arthritis and its Correlation with Disease Activity.

J Assoc Physicians India 2022 Apr;70(4):11-12

Rabindra Nath Tagore Medical College, Udaipur.

Rheumatoid arthritis (RA) is a chronic, symmetric, systemic inflammatory polyarthritis of unknown etiology. It primarily affects small diarthrodial joints of hand and has higher prevalence in women just like any other autoimmune disease. Metabolic Syndrome (MS) is a constellation of cardiovascular risk factors with insulin resistance as a core manifestation. Read More

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A Study of Pulmonary Function Tests in Patients with Rheumatoid Arthritis and its Association with Disease Activity.

J Assoc Physicians India 2022 Apr;70(4):11-12

SMS Medical College and Hospital, Hubli.

Rheumatoid arthritis is a chronic inflammatory disease of unknown etiology marked by a symmetrical peripheral polyarthritis. Because it is a systemic disease RA may result in a variety of extra articular manifestations, Pulmonary involvement is a well known extra-articular manifestation of RA which can have myriad presentations and might be the second cause of death after infection. Pulmonary function test(PFTs) are widely used to provide objective measure of lung function for detecting and quantifying impairment of pulmonary function in patients with cardiopulmonary diseases. Read More

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Orbital myositis in systemic lupus erythematosus: a case-based review.

Rheumatol Int 2022 08 19;42(8):1453-1460. Epub 2022 Apr 19.

Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, 45110, Ioannina, Greece.

Ocular complications occur in up to one-third of patients with systemic lupus erythematosus (SLE). Among them, orbital myositis (OM) is considered a rare manifestation that affects the extraocular muscles and causes pain and restriction with eye movement. We report a case of OM in a 48-year-old female with SLE and secondary Sjogren's Syndrome, who presented headache, periorbital edema, and painful ocular movements in both eyes, with no other systemic manifestations. Read More

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Acute Exacerbation of Rheumatoid Arthritis Misdiagnosed as COVID-19: A Case Report.

Front Med (Lausanne) 2022 10;9:844609. Epub 2022 Mar 10.

School of Medicine, Bahcesehir University, Istanbul, Turkey.

Background: Rheumatoid arthritis (RA) is a systemic inflammatory connective tissue disease that affects 1-2% of the population worldwide. Pulmonary manifestations including interstitial lung disease (ILD), airway disease, pleural and vascular disease can be seen in up to 30-40% of patients with RA, which are recognized as the second most frequent cause of death in RA patients. The simultaneous occurrence of COVID-19 in RA patients with or without ILD, and the similarities and differences between RA-related ILD and COVID-19 lung findings have been reported in the literature. Read More

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Association of common variable immunodeficiency and rare and complex connective tissue and musculoskeletal diseases. A systematic literature review.

Clin Exp Rheumatol 2022 May 28;40 Suppl 134(5):40-45. Epub 2022 Mar 28.

Policlinic and Hiller Research Unit for Rheumatology, ERN-ReCONNET member, University Clinic Duesseldorf, Heinrich-Heine-University Duesseldorf, Germany.

Objectives: To perform a systematic literature review (SLR) on the association of common variable immunodeficiency (CVID) and rare and complex connective tissue and musculoskeletal diseases, namely systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), idiopathic inflammatory myopathies (IIM), systemic sclerosis (SSc), relapsing polychondritis, antiphospholipid syndrome, immunoglobulin (Ig) G4-related disease, as well as undifferentiated and mixed connective tissue disease.

Methods: An SLR on studies and cases about the association of CVID and rare and complex connective tissue and musculoskeletal diseases was performed. Animal studies were excluded. Read More

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Organizing pneumonia as a possible pulmonary manifestation of systemic lupus erythematosus: Three cases and a review of literature.

Lupus 2022 May 26;31(6):737-743. Epub 2022 Mar 26.

Center for Rheumatic Diseases, 220937Mie University Hospital, Tsu, Japan.

Organizing pneumonia (OP) is a rare manifestation of systemic lupus erythematosus (SLE). It has been described in very few case reports. We encountered OP in three patients with SLE in 1 year; two manifested OP as an initial presentation of SLE, while the third manifested OP when SLE relapsed. Read More

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