606 results match your criteria Arthritis as a Manifestation of Systemic Disease


The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis.

Ci Ji Yi Xue Za Zhi 2019 Jan-Mar;31(1):5-10

Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.

Rheumatoid arthritis (RA) is a common systemic autoimmune disease. Its major manifestation is persistent joint inflammation, which can lead to bone destruction and severe disability. The immunopathogenesis of RA is very complex, involving both innate and adaptive immune systems. Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_116_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334572PMC
January 2019
1 Read

Lifestyle Modification in Rheumatoid Arthritis: Dietary and Physical Activity Recommendations Based on Evidence.

Curr Rheumatol Rev 2019 Jan 21. Epub 2019 Jan 21.

Department of Nutrition and Dietetics, Faculty of Health Sciences, Beirut Arab University, P.O. Box 11-5020 Riad El Solh, Beirut. Lebanon.

Background: Rheumatoid arthritis is systemic autoimmune disease, considered the most common inflammatory articular disease among the general population. However not only the joints are affected; rheumatoid arthritis also has an extra-articular manifestation. As for many other chronic diseases, rheumatoid arthritis may be exacerbated by poorer lifestyle choices. Read More

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http://dx.doi.org/10.2174/1573397115666190121135940DOI Listing
January 2019
7 Reads

Neurological Complications of Sjögren's Syndrome: Diagnosis and Management.

Curr Treatm Opt Rheumatol 2017 Dec 24;3(4):275-288. Epub 2017 Oct 24.

School of Medicine and Public Health, University of Wisconsin, Madison, USA.

Opinion Statement:

Purpose Of Review: Neurologic disease is a common extraglandular manifestation of Sjögren's syndrome (SS), the study of which has been hampered both by the lack of uniform definitions for specific neurologic complications and by the imprecision of the tools used to diagnose SS. There is a great need to develop consensus criteria for classifying these varied neurologic manifestations, as has been done in systemic lupus erythematosus (SLE) "Arthritis and rheumatism 42:599-608, 1999". SS patients with certain forms of neurologic involvement, such as small fiber neuropathy and sensory ataxic ganglionopathy, frequently lack anti-SSA and anti-SSB antibodies and other serologic abnormalities. Read More

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http://dx.doi.org/10.1007/s40674-017-0076-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322693PMC
December 2017
12 Reads

Main Oral Manifestations in Immune-Mediated and Inflammatory Rheumatic Diseases.

J Clin Med 2018 Dec 25;8(1). Epub 2018 Dec 25.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Internal Medicine, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milano, Italy.

Oral manifestations are frequent in patients with rheumatic diseases. The aim of this review is to offer readers practical advice concerning the onset, diagnosis and treatment of the main oral manifestations encountered in rheumatological and dental clinics. Signs and symptoms such as oral hyposalivation, xerostomia, temporomandibular joint disorders, periodontal disease, and dysphagia may be the first expression of a number of rheumatic diseases. Read More

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http://www.mdpi.com/2077-0383/8/1/21
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http://dx.doi.org/10.3390/jcm8010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351952PMC
December 2018
7 Reads

Primary respiratory disease in patients with systemic lupus erythematosus: data from the Spanish rheumatology society lupus registry (RELESSER) cohort.

Arthritis Res Ther 2018 Dec 19;20(1):280. Epub 2018 Dec 19.

Complexo Hospitalario Universitario de Vigo, Vigo, Spain.

Background: The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort.

Methods: All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Spanish Society of Rheumatology [SER], cross-sectional phase) registry were retrospectively investigated for the presence of primary pleuropulmonary manifestations.

Results: In total 3215 patients were included. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1776-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299951PMC
December 2018
9 Reads

[Systemic lupus erythematosus with acquired hemophilia A: a case report].

Authors:
F Yang Y S Zhou Y Jia

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1108-1111

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Acquired hemophilia A (AHA) is anunusual disease resulting from autoantibodies (inhibitors) against coagulation factor VIII (FVIII) and clinically manifests as bleeding, which sometimes can cause potentially limb-threatening or life-threatening situations. AHA is associated with cancers, auto-immune disorders, infections, dermatologic conditions and certain medications, among which it is commonly secondary to multiple rheumatologic conditions, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), pollymyositis, autoimmune hemolytic anemia and undifferentiated connective tissue disease. In autoimmune diseases, it may be the result of autoantibody producing against FVIII, and some cases of AHA may act as the first manifestation of SLE. Read More

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December 2018
15 Reads

Seizures as a clinical manifestation in somatic autoimmune disorders.

Seizure 2019 Jan 5;64:59-64. Epub 2018 Dec 5.

Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 5, Heemstede, 2103SW, Netherlands; NIHR University College London Hospitals Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, WC1N 3BG, United Kingdom; Chalfont Centre for Epilepsy, Chalfont St Peter, Bucks, SL9 0RJ, United Kingdom.

The risk of epileptic seizures seems increased in several systemic autoimmune disorders including systemic lupus erythematosus, type 1 diabetes mellitus, myasthenia gravis, celiac disease, rheumatoid arthritis, Hashimoto's encephalopathy, psoriasis, multiple sclerosis, neuromyelitis optica, and bullous pemphigoid. Immune dysfunction may be partly responsible for this association. Elevated levels of pro-inflammatory cytokines, autoantibodies seen in these autoimmune disorders and antibodies against neuronal antigens may contribute to the etiopathogenesis of seizures and epilepsy associated to immune conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183058
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http://dx.doi.org/10.1016/j.seizure.2018.11.012DOI Listing
January 2019
14 Reads
2.059 Impact Factor

Polyarteritis nodosa in case of familial Mediterranean fever.

Turk J Pediatr 2018 ;60(3):326-330

Division of Pediatric Nephrology, Department of Pediatrics, Marmara University Faculty of Medicine, İstanbul, Turkey.

Gökçe İ, Altuntaş Ü, Filinte D, Alpay H. Polyarteritis nodosa in case of familial Mediterranean fever. Turk J Pediatr 2018; 60: 326-330. Read More

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http://dx.doi.org/10.24953/turkjped.2018.03.016DOI Listing
January 2018
2 Reads

Uveitis and spondyloarthropathies.

Best Pract Res Clin Rheumatol 2017 12 25;31(6):846-862. Epub 2018 Oct 25.

Oxford Eye Hospital, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom. Electronic address:

Uveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6-9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2-5% in IBD), the presence of HLA-B27 and with increasing duration of disease. The majority of cases of uveitis in SpA are attributed to acute anterior uveitis but a minority of uveitis cases occur in the posterior segment of the eye. Read More

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http://dx.doi.org/10.1016/j.berh.2018.08.002DOI Listing
December 2017
1 Read
2.603 Impact Factor

Systemic Lupus Erythematous: Symptoms and Signs at Initial Presentations.

Antiinflamm Antiallergy Agents Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Rheumatology Department, Ministry of Health and Prevention, PO Box 65522, Dubai. Saudi Arabia.

Systemic lupus erythematosus (SLE) is an autoimmune multisystem inflammatory condition that causes microvascular inflammation with the production of various auto-antibodies that play a major role in its pathogenesis. SLE can affect both sexes, all ages, and all ethnic groups with widespread geographical and socioeconomic backgrounds. Asia encompasses people of many sociocultural backgrounds with diverse ethnic. Read More

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http://dx.doi.org/10.2174/1871523018666181128161828DOI Listing
November 2018
25 Reads

A Rare Case of Macrophage Activation Syndrome Presenting as the First Manifestation of Systemic Lupus Erythematosus.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618812196. Epub 2018 Nov 15.

State University of New York Upstate Medical University, Syracuse, NY, USA.

Macrophage activation syndrome (MAS) itself is a rare, potentially life-threatening complication of a rheumatic disease, mostly seen in juvenile idiopathic arthritis. It infrequently occurs in systemic lupus erythematosus (SLE), and it is extremely rare to be the first presentation of SLE. In a study of 511 patients with SLE, 7 cases (1. Read More

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http://dx.doi.org/10.1177/2324709618812196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243398PMC
November 2018
2 Reads

Combined pulmonary fibrosis and emphysema in systemic sclerosis: A syndrome associated with heavy morbidity and mortality.

Semin Arthritis Rheum 2018 Oct 13. Epub 2018 Oct 13.

Department of Internal Medicine, Service de Médecine Interne, Hôpital Cochin, Centre de Référence Maladies Systémiques Autoimmunes Rares d'Ile de France, DHU Authors (Autoimmune and Hormonal Diseases), Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. Electronic address:

Background: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) primarily due to tobacco smoking has been reported in connective tissue disease, but little is known about its characteristics in systemic sclerosis (SSc).

Methods: In this retrospective multi-center case-control study, we identified 36 SSc patients with CPFE, and compared them with 72 SSc controls with interstitial lung disease (ILD) without emphysema.

Results: Rate of CPFE in SSc patients with CT scan was 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172173051
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.011DOI Listing
October 2018
8 Reads

Psychosis in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study.

Arthritis Rheumatol 2019 Feb 18;71(2):281-289. Epub 2019 Jan 18.

University of Cambridge, Cambridge, UK.

Objective: To determine, in a large, multiethnic/multiracial, prospective inception cohort of patients with systemic lupus erythematosus (SLE), the frequency, attribution, clinical, and autoantibody associations with lupus psychosis and the short- and long-term outcomes as assessed by physicians and patients.

Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including psychosis. Scores on the Systemic Lupus Erythematosus Disease Activity Index 2000, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, and the Short Form 36 (SF-36) were recorded. Read More

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http://doi.wiley.com/10.1002/art.40764
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http://dx.doi.org/10.1002/art.40764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353684PMC
February 2019
18 Reads

Temporomandibular joint disorders as the only manifestation of juvenile idiopathic arthritis: a case report.

Einstein (Sao Paulo) 2018 Sep 6;16(3):eRC4003. Epub 2018 Sep 6.

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Juvenile idiopathic arthritis is a term used to include all chronic childhood arthritis of unknown etiology. It is characterized by chronic inflammation persisting for at least 6 weeks, beginning before 16 years of age. The characteristics present are chronic synovitis, arthralgia, impaired joint mobility in at least one joint, and erosion with destruction of cartilage and subchondral bone, that could be associated or not with systemic involvement, according to each subtype of the disease. Read More

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http://dx.doi.org/10.1590/S1679-45082018RC4003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122888PMC
September 2018
2 Reads

Advances in the treatment of uveitis in patients with spondyloarthritis - is it the time for biologic therapy?

Rom J Ophthalmol 2018 Apr-Jun;62(2):114-122

Department of Ophthalmology, University Emergency Hospital, Bucharest, Romania.

Spondyloarthritis (SpA) is a heterogeneous group of diseases that includes ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), inflammatory bowel disease-associated spondyloarthritis (IBD-SpA), and undifferentiated spondyloarthritis (unSpA). This group of diseases shares several clinical, imaging, and genetic features; the integration of these diseases in the group of SpA is needed for an early diagnosis and a prompt treatment. Uveitis is the most common extra-articular manifestation of SpA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117524PMC
February 2019
8 Reads

Ocular features of the HLA-B27-positive seronegative spondyloarthropathies.

Curr Opin Ophthalmol 2018 Nov;29(6):552-557

Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin Eye Institute, Milwaukee, Wisconsin, USA.

Purpose Of Review: The seronegative spondyloarthropathies are a closely related group of inflammatory diseases that include ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthritis, inflammatory bowel disease and undifferentiated spondyloarthritis. This review focuses on the spectrum of ocular manifestations associated with these diseases and the current approaches in treating these ocular manifestations. It also highlights the role ophthalmologists can play in identifying and appropriately treating human leukocyte antigen B27 (HLA-B27) associated uveitis and the associated spondyloarthropathies in order to limit ocular and systemic morbidity. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000525DOI Listing
November 2018
14 Reads

Effectiveness of clarithromycin in patients with yellow nail syndrome.

BMC Pulm Med 2018 Aug 15;18(1):138. Epub 2018 Aug 15.

Department of Respiratory Medicine, National Center for Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: Yellow nail syndrome (YNS) is a rare disease characterized by the triad of thickened, slow-growing yellow nails, lymphedema, and chronic respiratory manifestations. The cause of YNS is not known; however, it is suggested to be due to a congenital lymph abnormality. Since YNS is accompanied by chronic bronchial infection in more than half of patients, we hypothesized that treatment with clarithromycin (CAM) could be effective. Read More

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http://dx.doi.org/10.1186/s12890-018-0707-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094584PMC
August 2018
19 Reads

Characteristics of inflammatory eye disease associated with hidradenitis suppurativa.

Eur J Rheumatol 2018 Sep 22;5(3):165-168. Epub 2018 Jun 22.

Department of Rheumatology, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio, USA.

Objective: Hidradenitis suppurativa (HS) is an inflammatory skin condition that can cause profound morbidity. Patients can present with recurrent nodules, sinus tract formation, abscesses, and/or scarring, mainly affecting the intertriginous areas. Case reports have documented the coexistence of HS and inflammatory eye disease (IED). Read More

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http://dx.doi.org/10.5152/eurjrheum.2018.17163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116841PMC
September 2018
10 Reads

Cutaneous vasculitis in rheumatologic disease: Current concepts of skin and systemic manifestations.

Clin Dermatol 2018 Jul - Aug;36(4):561-566. Epub 2018 Apr 10.

Departments of Dermatology and Medicine, Perelman Center for Advanced Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:

Cutaneous vasculitis may be limited to the skin, a manifestation of systemic vasculitis, or a sign of an important underlying disease state. A thorough and systematic approach is required for accurate diagnosis and evaluation of such patients to enable appropriate management of the vasculitis and any associated condition. Occasionally, cutaneous vasculitis is a manifestation or presenting sign of connective tissue disease, such as systemic lupus erythematosus, Sjögren syndrome, or another condition. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2018.04.012DOI Listing
December 2018
3 Reads

Classification of primary antiphospholipid syndrome as systemic lupus erythematosus: Analysis of a cohort of 214 patients.

Autoimmun Rev 2018 Sep 10;17(9):866-872. Epub 2018 Jul 10.

Université Paris Descartes-Sorbonne Paris Cité, France; AP-HP, Centre de référence maladies auto-immunes et systémiques rares de l'île de France, Service de médecine interne Pôle médecine, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris cedex 14, France; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. Electronic address:

Objectives: To assess the limitations of the SLICC (Systemic Lupus International Collaborating Clinics) classification criteria for systemic lupus erythematosus (SLE), in patients with primary antiphospholipid syndrome (PAPS).

Methods: Retrospective study of a cohort of APS patients (Sydney criteria). We successively excluded patients with (1) at least one "SLE-specific" manifestation (biopsy-proven SLE nephropathy, arthritis, cutaneous, or neurologic SLE manifestations, pericarditis, autoimmune haemolytic anaemia, oral and nasal ulcers, non-scarring alopecia, anti-dsDNA, and anti-Sm antibodies), (2) any other autoimmune connective tissue disease, and/or (3) antinuclear antibodies >1/320. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.03.011DOI Listing
September 2018
14 Reads

Extravascular manifestations of Takayasu arteritis: focusing on the features shared with spondyloarthritis.

Arthritis Res Ther 2018 07 11;20(1):142. Epub 2018 Jul 11.

Division of Rheumatology, Department of Internal Medicine, University of Ulsan, College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Background: Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to identify the association between vascular and extravascular manifestations of TAK. Read More

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http://dx.doi.org/10.1186/s13075-018-1643-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042334PMC
July 2018
5 Reads

Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management.

J Immunol Res 2018 27;2018:6061825. Epub 2018 May 27.

Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, Italy.

Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. Read More

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https://www.hindawi.com/journals/jir/2018/6061825/
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http://dx.doi.org/10.1155/2018/6061825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994274PMC
October 2018
4 Reads

Isolated Knee Arthritis as Early and Only Symptom of Whipple's Disease.

Case Rep Med 2018 27;2018:3417934. Epub 2018 May 27.

Servizio di Chirurgia e Ortopedia, Ospedale Regionale di Lugano, EOC, Ticino, Switzerland.

We report a case of isolated Whipple's disease involving the knee of a 64-year-old female patient who presented recurrent monoarthritis whose origin was not clear. Initially, the cause of the gradually invalidating symptoms was related to a meniscal lesion and a diffuse minor grade chondropathy, but pain and functional impairment suggested that more exams were needed. Biopsies were performed during arthroscopy. Read More

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http://dx.doi.org/10.1155/2018/3417934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994299PMC
May 2018
18 Reads

Obliterative bronchiolitis associated with rheumatoid arthritis: analysis of a single-center case series.

BMC Pulm Med 2018 Jun 22;18(1):105. Epub 2018 Jun 22.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.

Background: Rheumatoid arthritis (RA) is a systemic autoimmune condition characterized by erosive inflammation of the joints. One rare pulmonary manifestation is obliterative bronchiolitis (OB), a small airways disease characterized by the destruction of bronchiolar epithelium and airflow obstruction.

Methods: We retrospectively reviewed the clinical data of patients with rheumatoid arthritis-associated obliterative bronchiolitis (RA-OB) from 01/01/2000 to 12/31/2015. Read More

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http://dx.doi.org/10.1186/s12890-018-0673-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013859PMC
June 2018
6 Reads

Predictors of positive F-FDG PET/CT-scan for large vessel vasculitis in patients with persistent polymyalgia rheumatica.

Semin Arthritis Rheum 2018 May 18. Epub 2018 May 18.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain; University of Cantabria, School of Medicine, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address:

Objective: Polymyalgia rheumatica (PMR) is often the presenting manifestation of giant cell arteritis (GCA). Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scan often discloses the presence of large vessel vasculitis (LVV) in PMR patients. We aimed to identify predictive factors of a positive PET/CT scan for LVV in patients classified as having isolated PMR according to well-established criteria. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.05.007DOI Listing
May 2018
33 Reads

Scleromalacia perforans: a case report.

J Med Case Rep 2018 Jun 5;12(1):155. Epub 2018 Jun 5.

Department of Medicine, Jinnah Medical and Dental College, 22-23 Shaheed-e-Millat Road, Karachi, Pakistan.

Background: Scleromalacia perforans is a rare ocular manifestation of rheumatoid arthritis which can potentially lead to blindness and is a late consequence in the course of the disease. It is an unusual finding for it to be present in a patient with joint pain without any rheumatologic progression of disease.

Case Presentation: We describe a rare case of scleromalacia perforans and orbital inflammatory disease in a 40-year-old Pakistani woman with apparently no associated rheumatologic deformity. Read More

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http://dx.doi.org/10.1186/s13256-018-1686-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987604PMC
June 2018
6 Reads

The Eyes Have it: A Rheumatologist's View of Uveitis.

Arthritis Rheumatol 2018 Oct 23;70(10):1533-1543. Epub 2018 Aug 23.

University College London, National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital, London, UK, and University of Bristol, Bristol Eye Hospital, Bristol, UK.

Uveitis is defined as intraocular inflammation. It is an extraarticular manifestation of many forms of joint disease, which include spondyloarthritis, juvenile idiopathic arthritis, and Behçet's disease. Rheumatologists may be asked to consult on the ophthalmologic care of patients with uveitis in order to identify an associated systemic illness. Read More

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http://dx.doi.org/10.1002/art.40568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160350PMC
October 2018
18 Reads

Systemic Lupus Erythematosus and Sjögren's Syndrome Complicated by Conversion Disorder: a Case Report.

Kurume Med J 2018 Jul 21;64(4):97-101. Epub 2018 May 21.

Department of Pediatrics and Child Health, Kurume University School of Medicine.

Conversion disorder (CD) is sometimes accompanied by motor and sensory impairments, such as muscle weakness, paralysis, sensory hypersensitivity, and sensory loss. Sjögren's syndrome (SS) complicates 5-10% of cases of systemic lupus erythematosus (SLE). Patients with SS or SLE present with various neurological symptoms and psychiatric manifestations. Read More

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http://dx.doi.org/10.2739/kurumemedj.MS644005DOI Listing
July 2018
6 Reads

Juvenile idiopathic arthritis-associated uveitis.

Best Pract Res Clin Rheumatol 2017 08 26;31(4):517-534. Epub 2018 Feb 26.

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol, BS2 8BJ, UK. Electronic address:

Juvenile idiopathic arthritis (JIA) is the commonest rheumatic disease in children and JIA-associated uveitis its most frequent extra-articular manifestation. The uveitis is potentially sight-threatening and thus carries a considerable risk of morbidity with associated reduction in quality of life. The commonest form of uveitis seen in association with JIA is chronic anterior uveitis, which is almost always asymptomatic in the initial stages. Read More

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http://dx.doi.org/10.1016/j.berh.2018.01.002DOI Listing
August 2017
19 Reads

[Intra-cardiac manifestation during adult-onset Still's disease's, a tricuspid vegetation as a rare expression of systemic disease].

Rev Med Interne 2018 Oct 3;39(10):816-819. Epub 2018 May 3.

Service de médecine interne, centre hospitalier universitaire de Rennes, hôpital Sud, 16, boulevard de Bulgarie, 35203 Rennes cedex, France; UMR Inserm U1085, université de Rennes 1, Institut de recherche sur la santé, l'environnement et le travail (IRSET), 35000 Rennes, France.

Introduction: Adult-onset Still's Disease is a rare multisystemic inflammatory disease characterized by fever, maculo-papular erythematous rash and arthralgia. Adult-onset Still's disease is a diagnosis of exclusion.

Case Report: We report the case of a 33 years old man, hospitalized for fever, arthralgia and throat manifestations, leading to Adult-onset Stills's Disease diagnosis. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.04.016DOI Listing
October 2018

Oral mucosa lesions as atypical manifestation of adult-onset Still´s disease.

An Bras Dermatol 2018 Mar;93(2):271-273

Pathological Anatomy Deparment, Clínica Pergamino, Pergamino, Argentina.

Adult-onset Still's disease is a systemic inflammatory disorder of unknown etiology, characterized by skin rash, spiking fever, arthralgias or arthritis, and leukocytosis. The typical skin rash is evanescent, salmon-pink, nonpruritic and maculopapular, predominantly on the extremities. It is considered one of the major Yamaguchi's criteria in adult-onset Still's disease. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20186836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916405PMC
March 2018
5 Reads

Juvenile Idiopathic Arthritis Associated with Combined JP-HHT Syndrome: A Novel Phenotype Associated with a Novel Variant in .

J Pediatr Genet 2018 Jun 29;7(2):78-82. Epub 2017 Dec 29.

Department of Medical Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

Juvenile polyposis (JP) syndrome is characterized by multiple hamartomatous polyps of the gastrointestinal tract. Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia characterized by telangiectasia in the skin, mucous membranes, and arteriovenous malformations in other organs. Individuals with JP-HHT syndrome have variable features of both rare disorders, attributed to heterozygous mutations in the gene. Read More

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http://dx.doi.org/10.1055/s-0037-1609060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916806PMC
June 2018
14 Reads

Diagnosis of pseudo-gout (calcium pyrophosphate deposition disease) clinched on cytology.

Diagn Cytopathol 2018 Sep 11;46(9):748-751. Epub 2018 Apr 11.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Calcium pyrophosphate dihydrate (CPPD) deposition disease is a metabolic arthropathy which results from deposition of calcium pyrophosphate crystals in and around joints especially the hyaline cartilage and disc material. This metabolic disease in uncommon in the smaller joints and multiple diagnostic modalities along with biochemical investigations would be necessary for definite diagnosis. We highlight the case of a 48 year old male who presented with a painful mass at the base of left thumb and was clinic-radiologically suspected as malignancy. Read More

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http://dx.doi.org/10.1002/dc.23939DOI Listing
September 2018
6 Reads

Craniofacial Manifestations of Systemic Disorders: CT and MR Imaging Findings and Imaging Approach.

Radiographics 2018 May-Jun;38(3):890-911. Epub 2018 Apr 6.

From the Departments of Radiology (V.C.A.A., M.N.C., H.K., A.F., O.S.), Otolaryngology-Head and Neck Surgery (O.S.), and Radiation Oncology (O.S.), Boston University Medical Center, Boston University School of Medicine, 820 Harrison Ave, 3rd Floor, Boston, MA 02118.

Many systemic diseases or conditions can affect the maxillofacial bones; however, they are often overlooked or incidentally found at routine brain or head and neck imaging performed for other reasons. Early identification of some conditions may significantly affect patient care and alter outcomes. Early recognition of nonneoplastic hematologic disorders, such as thalassemia and sickle cell disease, may help initiate earlier treatment and prevent serious complications. Read More

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http://dx.doi.org/10.1148/rg.2018170145DOI Listing
October 2018
4 Reads

IL-6 blockade in systemic juvenile idiopathic arthritis - achievement of inactive disease and remission (data from the German AID-registry).

Pediatr Rheumatol Online J 2018 Apr 5;16(1):22. Epub 2018 Apr 5.

Department of Pediatric Rheumatology, University Children's Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.

Background: Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed to proinflammatory cytokines like interleukin-6 (IL-6), and effective drugs inhibiting their signaling are being developed. This study evaluates sJIA patients treated with the IL-6 inhibitor tocilizumab (TCZ) concerning clinical response rate, disease course and adverse effects in a real-life clinical setting. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-018-0236-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887199PMC
April 2018
9 Reads

Myasthenia Gravis and Associated Diseases.

Open Access Maced J Med Sci 2018 Mar 5;6(3):472-478. Epub 2018 Mar 5.

Institute for Epidemiology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Myasthenia gravis (MG) is an autoimmune disease caused by the action of specific antibodies to the postsynaptic membrane of the neuromuscular junction, leading to impaired neuromuscular transmission. Patients with MG have an increased incidence of other autoimmune diseases.

Aim: to determine the presence of other associated diseases in patients with MG. Read More

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http://dx.doi.org/10.3889/oamjms.2018.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874368PMC
March 2018
7 Reads

[Systemic sclerosis in 2017].

Vnitr Lek 2018 ;64(2):146-154

Systemic sclerosis is classed as a diffuse (systemic) disease of connective tissue. It is a heterogeneous disease significantly shortening life expectancy. Its etiology is unknown. Read More

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January 2018
7 Reads

β2-microglobulin as a marker of systemic lupus erythematosus activity.

Adv Clin Exp Med 2018 Mar;27(3):379-382

Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Poland.

Background: Systemic lupus erythematosus (SLE) is characterized by alternating periods of activity and remission. A portion of the patients suffers from the chronically active form of the disease. The search for clinically useful markers of its activity is ongoing. Read More

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http://www.advances.umed.wroc.pl/en/article/2018/27/3/379/
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http://dx.doi.org/10.17219/acem/68291DOI Listing
March 2018
19 Reads

Ultrasonography for diagnosis, monitoring and treatment of tenosynovitis in patients with rheumatoid arthritis.

Dan Med J 2018 Mar;65(3)

Rheumatod arthritis is a chronic systemic autoimmune disease, characterized by inflammation in joints and tendon sheaths, which frequently leads to permanent and serious disability due to joint destruction, but also tendon and ligament ruptures. Clinical management of rheumatoid arthritis has traditionally been supported by biochemical and radiographic findings. However, imaging modalities like ultrasound and magnetic resonance imaging (MRI) have improved the possibility for better management of rheumatoid arthritis patients, due to higher sensitivity and specificity for detecting ongoing inflammation, this thesis is focusing on tenosynovitis as recent studies have shown that inflammation in tendon sheaths, i. Read More

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March 2018
16 Reads

Clinical Correlates, Outcomes, and Predictors of Inflammatory Ocular Disease Associated with Rheumatoid Arthritis in the Biologic Era.

J Rheumatol 2018 May 15;45(5):595-603. Epub 2018 Feb 15.

From the Unit of Rheumatology, Department of Medicine, University of Verona, Verona, Italy; Division of Rheumatology, Department of Internal Medicine; Division of Biomedical Informatics, Department of Health Science Research; Division of Epidemiology, Department of Health Science Research; Department of Ophthalmology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

Objective: Inflammatory ocular disease (IOD) is a rare but severe extraarticular manifestation of rheumatoid arthritis (ExRA) with high mortality. The aim of our study was to examine clinical characteristics of IOD in rheumatoid arthritis (RA) and their effect on disease severity and outcomes in recent years.

Methods: A retrospective cohort of RA patients with IOD evaluated between 1996 and 2013 was assembled and compared to RA comparators without IOD and matched for age, sex, and disease duration. Read More

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http://dx.doi.org/10.3899/jrheum.170437DOI Listing
May 2018
44 Reads

Gene mutations and clinical phenotypes in 15 Chinese children with cryopyrin-associated periodic syndrome (CAPS).

Sci China Life Sci 2017 12 2;60(12):1436-1444. Epub 2017 Dec 2.

Department of Rheumatology and Immunology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

The aim of our study is to explore the features of clinical manifestations and genetic mutations in Chinese CAPS patients. Fifteen confirmed patients with CAPS were enrolled. The onset time ranges from 2 days after birth to 6 years and 1 month. Read More

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http://dx.doi.org/10.1007/s11427-017-9246-4DOI Listing
December 2017
20 Reads

Fitz-Hugh-Curtis Syndrome Caused by Gonococcal Infection in a Patient with Systemic Lupus Erythematous: A Case Report and Literature Review.

Am J Case Rep 2017 Dec 29;18:1396-1400. Epub 2017 Dec 29.

Department of Internal Medicine, Hospital de Clínicas "Jose de San Martin", University of Buenos Aires, Buenos Aires, Argentina.

BACKGROUND Fitz-Hugh-Curtis (FHC) syndrome is a perihepatitis linked to inflammatory pelvic disease. It can be caused by Neisseria gonorrhoeae or Chlamydia trachomatis infections. FHC syndrome usually presents with pain in the right hypochondrium and fever, associated with symptoms and signs of pelvic infection in women. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755950PMC
December 2017
23 Reads

Clinical, Epidemiological, and Histopathological Features of Respiratory Involvement in Rheumatoid Arthritis.

Biomed Res Int 2017 7;2017:7915340. Epub 2017 Nov 7.

Rheumatology Unit, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy.

Although by definition rheumatoid arthritis (RA) is an articular disorder, it is a systemic disease, and 18-40% of patients experience extra-articular manifestations (EAMs). The involvement of the respiratory system occurs in about 30-40% of RA patients, and in about 10-20% of them it represents the first manifestation of RA. A wide range of pulmonary manifestations are detectable in RA patients, including pulmonary parenchymal disease, pleural involvement, and airway and pulmonary inflammation. Read More

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http://dx.doi.org/10.1155/2017/7915340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697381PMC
July 2018
22 Reads

Interstitial lung disease in systemic autoimmune rheumatic diseases: a comprehensive review.

Expert Rev Clin Immunol 2018 01 11;14(1):69-82. Epub 2017 Dec 11.

b Rheumatology Unit, Department of Internal Medicine , ASST-Fatebenefratelli L. Sacco University Hospital , Milan , Italy.

Background: Interstitial lung diseases (ILDs) are among the most serious complications associated with systemic rheumatic diseases, and lead to significant morbidity and mortality; they may also be the first manifestation of connective tissue diseases (CTDs). The aim of this narrative review is to summarise the data concerning the pathogenesis of CTD/ILD and its distinguishing features in different rheumatic diseseas. Areas covered: The pathogenesis, clinical aspects and treatment of ILD associated with rheumatic systemic diseases and CTDs were reviewed by searching the PubMed, Medline, and Cochrane Library databases for papers published between 1995 and February 2017 using combinations of words or terms. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2018.1
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http://dx.doi.org/10.1080/1744666X.2018.1411190DOI Listing
January 2018
62 Reads

Association of Defective Regulation of Autoreactive Interleukin-6-Producing Transitional B Lymphocytes With Disease in Patients With Systemic Sclerosis.

Arthritis Rheumatol 2018 03 6;70(3):450-461. Epub 2018 Feb 6.

Queen Mary University of London, London, UK.

Objective: Systemic sclerosis (SSc) has the highest case-specific mortality of any rheumatic disease, and no effective therapy is available. A clear manifestation of SSc is the presence of autoantibodies. However, the origin of autoantibody-producing B lymphocytes, their mechanisms of activation and autoantibody production, and their role remain unclear. Read More

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http://dx.doi.org/10.1002/art.40390DOI Listing
March 2018
20 Reads

Clinical, histological, immunological presentations and outcomes of bullous systemic lupus erythematosus: 10 New cases and a literature review of 118 cases.

Semin Arthritis Rheum 2018 08 4;48(1):83-89. Epub 2017 Nov 4.

AP-HP, Service de Médecine Interne 2, Centre National de Référence des Maladies Systémiques Rares, Lupus et Syndrome des Anticorps antiphospholipides, Institut e3m, Groupe Hospitalier Pitié-Salpêtrière, Paris 75013, France; Université Paris VI Pierre et Marie Curie, Sorbonnes Universités, Paris 75013, France.

Background: Bullous systemic lupus erythematosus (BSLE) is a rare blistering condition associated with systemic lupus erythematosus (SLE).

Patients And Methods: We conducted a multi-center retrospective study and literature review in order to describe the clinical, immunological, and histological presentations and outcomes of BSLE. The skin biopsies were centrally reviewed, and sera obtained during a flare of BSLE were analyzed for identification of circulating anti-basement membrane zone antibodies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172173030
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http://dx.doi.org/10.1016/j.semarthrit.2017.11.003DOI Listing
August 2018
27 Reads
3.925 Impact Factor

Cytokines in the pathogenesis of hemophilic arthropathy.

Cytokine Growth Factor Rev 2018 02 13;39:71-91. Epub 2017 Nov 13.

Department of Neuroorthopaedics and Neurology, Eleonora Reicher National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, Poland. Electronic address:

Hemophilic arthropathy (HA) is one of the most common and typical manifestation in the course of recurrent bleeding episodes in patients with hemophilia. Clinical and subclinical joint bleeding episodes gradually lead to irreversible changes manifesting themselves as pain, progressing ankylosis, marked limitation of the range of motion, muscle atrophy and osteoporosis commonly concomitant with joint deformity resulting from chronic proliferative synovitis and both cartilage and bone degeneration leading to the final functional impairment of the joint. In spite of numerous studies, the pathophysiology of HA has not been fully elucidated, especially as regards immunopathological mechanisms which are associated with the subclinical and early stage of the disease and to be more precise, with chronic joint inflammation. Read More

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http://dx.doi.org/10.1016/j.cytogfr.2017.11.003DOI Listing
February 2018
8 Reads

Cardiovascular disease in patients with autoinflammatory syndromes.

Rheumatol Int 2018 Jan 1;38(1):37-50. Epub 2017 Nov 1.

Academic Research Unit, 2nd Department of Internal Medicine, Kepler University Hospital, Med Campus III, Krankenhausstr. 9, 4020, Linz, Austria.

Autoinflammatory syndromes (AIS) are characterized by recurring events of inflammation, leading to a variety of organ manifestations and fever attacks. A subgroup of AIS is commonly referred to as hereditary periodic fever syndromes (HPFS). There is substantial evidence that autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are strongly associated with cardiovascular morbidity and mortality. Read More

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http://dx.doi.org/10.1007/s00296-017-3854-7DOI Listing
January 2018
22 Reads

An Overview of the Extraarticular Involvement in Rheumatoid Arthritis and its Management.

J Pharmacol Pharmacother 2017 Jul-Sep;8(3):81-86

Department of Rheumatology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Rheumatoid arthritis (RA) is an autoimmune systemic disease characterized by long-standing inflammation and significant joint destruction. Despite significant research and success toward the treatment modalities, complete remission still remains a challenge. Even then a number of early and late extraarticular manifestations (EAMs) of the disease further complicate the disease progression. Read More

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http://dx.doi.org/10.4103/jpp.JPP_194_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642136PMC
October 2017
15 Reads

[The role of the human microbiom in the pathogenesis of rheumatoid arthritis - a literature review].

Wiad Lek 2017;70(4):798-803

Oddział Reumatologii Miejskiego Szpitala Zespolonego W Olsztynie, Olsztyn, Polska.

Rheumatoid arthritis is a chronic, progressive, autoimmune disease with numerous articular, extra-articular and systemic manifestations. The cause of rheumatoid arthritis is multifactorial including genetic and environmental factors. Recent advantages in sequencing techniques have allowed the deep characterization of the human microbiota. Read More

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March 2018
40 Reads