740 results match your criteria Arthritis as a Manifestation of Systemic Disease

Comparative evaluation of clinical findings and prognostic outcome parameters in hospitalized, critically ill neonatal foals and crias.

J Vet Emerg Crit Care (San Antonio) 2021 Jul 29. Epub 2021 Jul 29.

Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts.

Objective: Species-related differences in the prevalence, manifestation, and outcome of neonatal illness may impact management practices of neonatal intensive care. The study aimed to elucidate similarities between disease manifestations and mortality risks of critically ill (CI) neonatal crias and foals admitted to the same referral center.

Design: A comparative, retrospective cohort evaluation of two species (camelid and equine). Read More

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[Post-Corona-Virus-Disease‑19 arthritis. Manifestation under the clinical picture of a reactive arthritis].

H Zeidler

Z Rheumatol 2021 Aug 9;80(6):555-558. Epub 2021 Jul 9.

Medizinische Hochschule Hannover, Carl-Neuberg Str. 1, 30625, Hannover, Deutschland.

A total of 13 case reports of reactive arthritis reported in the literature in connection with coronavirus disease 2019 (COVID‑19) are reviewed. Men were affected more frequently than women. The arthritis was manifested 4-44 days after the infection or the occurrence of the COVID‑19 symptoms. Read More

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Extended Inflammation Parameters (EIP) as Markers of Immune System Cell Activation in Psoriasis.

Int J Inflam 2021 14;2021:9216528. Epub 2021 Jun 14.

Department of Biochemical Diagnostics, Chair of Laboratory Diagnostics, Medical University of Lublin, Lublin, Poland.

Psoriasis is an inflammatory, autoimmune disease that affects approximately 2% of the population. The inflammation in psoriasis can be systemic, so despite a predominantly cutaneous manifestation, it also affects the internal organs. The diagnosis and monitoring of the disease are based on the clinical picture. Read More

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Principles of pediatric lupus nephritis in a prospective contemporary multi-center cohort.

Lupus 2021 Jul 4:9612033211028658. Epub 2021 Jul 4.

Lupus Genomics and Global Disparities Unit, Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

Lupus nephritis (LN) is a life-threatening manifestation of systemic lupus erythematosus (SLE) and is more common in children than adults. The epidemiology and management of childhood-onset SLE (cSLE) have changed over time, prompting the need to reassess expected outcomes. The purpose of this study is to use the Childhood Arthritis and Rheumatology Research Alliance (CARRA) prospective registry to validate historical principles of LN in a contemporary, real-world cohort. Read More

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Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management.

Eur Respir Rev 2021 Jun 23;30(160). Epub 2021 Jun 23.

Dept of Medicine, Center for Interstitial Lung Diseases, University of Washington, Seattle, WA, USA

Rheumatoid arthritis (RA) is a systemic inflammatory disorder, with the most common extra-articular manifestation of RA being lung involvement. While essentially any of the lung compartments can be affected and manifest as interstitial lung disease (ILD), pleural effusion, cricoarytenoiditis, constrictive or follicular bronchiolitis, bronchiectasis, pulmonary vasculitis, and pulmonary hypertension, RA-ILD is a leading cause of death in patients with RA and is associated with significant morbidity and mortality. In this review, we focus on the common pulmonary manifestations of RA, RA-ILD and airway disease, and discuss evolving concepts in the pathogenesis of RA-associated pulmonary fibrosis, as well as therapeutic strategies, and have revised our previous review on the topic. Read More

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Osteomyelitis and Septic Arthritis Due to : A 10-Year Retrospective Melioidosis Study From South China.

Front Cell Infect Microbiol 2021 28;11:654745. Epub 2021 May 28.

Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Clinical Research Center of Respiratory Diseases, Beijing, China.

is the causative agent of melioidosis, endemic mainly in tropical and subtropical areas. Its clinical manifestation is broad ranging from a localized skin lesion to a life-threatening systemic disease. Osteomyelitis and septic arthritis caused by are a rare, fatal illness, whose clinical features have not been illustrated in mainland China. Read More

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A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome.

Nat Commun 2021 06 10;12(1):3523. Epub 2021 Jun 10.

Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development, Suresnes, France.

There is currently no approved treatment for primary Sjögren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pathophysiology of the disease. Finding common molecular signatures among patient subgroups could improve our understanding of disease etiology, and facilitate the development of targeted therapeutics. Read More

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[Lung involvement in rheumatic diseases].

Dtsch Med Wochenschr 2021 Jun 1;146(11):752-756. Epub 2021 Jun 1.

Abteilung Innere Medizin, Rheumatologie, Klinische Immunologie und Osteologie, Immanuel-Krankenhaus Berlin, Standort Berlin-Wannsee.

Lung involvement is one of the most frequent organ manifestation in rheumatic diseases (CTD-ILD). Especially patients with rheumatoid arthritis, systemic sclerosis, and idiopathic inflammatory myopathies are affected. Interstitial lung diseases (ILD) are still associated with significant morbidity and mortality. Read More

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Frequency of Cardiovascular Manifestation in Patients With Rheumatoid Arthritis.

Cureus 2021 Apr 22;13(4):e14631. Epub 2021 Apr 22.

Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Introduction Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease. The increased inflammatory burden in RA may result in atherosclerosis, myocardial infarction (MI), and subsequent mortality. In this study, we will determine the frequency of cardiovascular manifestation in RA patients through history, laboratory workup, and echocardiography. Read More

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Quantitative analysis of the natural history of prolidase deficiency: description of 17 families and systematic review of published cases.

Genet Med 2021 May 26. Epub 2021 May 26.

Department of Dermatology, University Hospital Münster, Münster, Germany.

Purpose: Prolidase deficiency is a rare inborn error of metabolism causing ulcers and other skin disorders, splenomegaly, developmental delay, and recurrent infections. Most of the literature is constituted of isolated case reports. We aim to provide a quantitative description of the natural history of the condition by describing 19 affected individuals and reviewing the literature. Read More

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Biologics and small molecules in the management of psoriatic arthritis: Reproduction related issues in female and male patients.

Expert Rev Clin Pharmacol 2021 May 13:1-11. Epub 2021 May 13.

Department of Rheumatology, Sorlandet Hospital, Kristiansand, Norway.

STRACT: Psoriatic arthritis (PsA) is the musculoskeletal manifestation of psoriatic disease, an inflammatory systemic disease with a high incidence in the reproductive years. Biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) as well as 'small molecules', are increasingly used to treat subtypes of PsA. Safety concerns exist in the field of fertility for PsA patients since the literature shows discordant results toward the influence of anti-psoriatic drugs. Read More

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Effect of Myd88 deficiency on gene expression profiling in salivary glands of female non-obese diabetic (NOD) mice.

J Oral Biosci 2021 06 30;63(2):192-198. Epub 2021 Apr 30.

Department of Oral Microbiology, Division of Oral Infection Health Sciences, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu, 501-0296, Japan. Electronic address:

Objectives: Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by inflammatory lesions in the salivary and lacrimal glands, which are caused by distinct lymphocytic infiltrates. Female non-obese diabetic (NOD) mice spontaneously develop inflammatory lesions of the salivary glands with SS-like pathological features. Previous studies have shown that MyD88, a crucial adaptor protein that activates innate immune signaling, affects lymphocytic infiltration, but its detailed role remains unclear. Read More

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The possible role of oral microbiome in autoimmunity.

Int J Womens Dermatol 2020 Dec 4;6(5):357-364. Epub 2020 Aug 4.

Department of Oral Medicine and Maxillofacial Pathology, School of Dentistry, Aristotle University of Thessaloniki, Greece.

Objective: The human microbiome refers to the entire habitat, including microorganisms, their genomes and the surrounding environmental conditions of the microbial ecosystem. When the equilibrium between microbial habitats and host is disturbed, dysbiosis is caused. The oral microbiome (OMB) has been implicated in the manifestation of many intra- and extraoral diseases. Read More

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December 2020

Function and Role of Regulatory T Cells in Rheumatoid Arthritis.

Front Immunol 2021 1;12:626193. Epub 2021 Apr 1.

Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune diseases is the loss of tolerance to self or harmless antigens. The loss or functional deficiency of key immune cells, regulatory T (Treg) cells, has been confirmed in human autoimmune diseases. Read More

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Clinico-radiological profile of connective tissue disease related-interstitial lung diseases from a tertiary care centre of India: a cross sectional study.

Monaldi Arch Chest Dis 2021 Apr 2. Epub 2021 Apr 2.

Department of Pulmonary Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur.

Interstitial lung diseases (ILDs) are a frequently occurring pulmonary manifestation in patients of connective tissue diseases (CTD). Detailed understanding of this subset of lung diseases is vital, hence the study was conducted to analyze the clinico-radiological characteristics of CTD-ILD. The present study was conducted between March 2017 to February 2018 at a tertiary care teaching hospital from western India. Read More

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[Atypical arthritis of the hands : Collagenosis-part 2].

Matthias Bollow

Radiologe 2021 May 1;61(5):470-482. Epub 2021 Apr 1.

Klinik für diagnostische und interventionelle Radiologie, Augusta-Kranken-Anstalt Bochum, Bergstraße 26, 44791, Bochum, Deutschland.

Background: Progressive systemic scleroderma (PSS) and mixed connective tissue disease (MCTD) represent vasculitic autoimmune diseases from the group of collagenoses with manifestations in various organ systems such as the skin, the internal organs and the joints.

Objective: To present the atypical arthritis patterns of the hands in PSS and MCTD that differ from those in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) in the context of clinical and serologic findings and in consideration of the classification of PSS and MCTD.

Materials And Methods: Narrative review based on the current literature on the subject from the radiological and rheumatological point of view. Read More

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Sjogren's Syndrome and Pulmonary Disease.

Adv Exp Med Biol 2021 ;1303:193-207

Division of Pulmonary & Critical Care Medicine, Albany Medical College, Albany, NY, USA.

Sjogren's syndrome is an autoimmune connective tissue disease targeting the exocrine glands and frequently affecting the respiratory system. The pulmonary disease is the most important extra-glandular manifestation as it carries most of the morbidity and mortality. Typically, it affects the small airways ranging from mild to severe respiratory symptoms. Read More

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Isolated brachial artery aneurysm: a rare presentation of paediatric Behçet's disease.

Ann R Coll Surg Engl 2021 Mar;103(3):e94-e97

Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Behçet's disease is a rare disease characterised by recurrent oral ulcers, with systemic manifestations including genital ulcers, ocular disease, skin lesions, gastrointestinal disease, neurologic disease, vascular disease and arthritis. Most clinical manifestations of Behçet's disease are believed to be due to vasculitis. The heterogeneous clinical spectrum is influenced by sex, ethnicity and country of residence. Read More

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Interstitial lung disease throughout the rheumatoid arthritis disease course.

Curr Opin Rheumatol 2021 May;33(3):284-291

Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.

Purpose Of Review: To summarize the current understanding of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) throughout the rheumatoid arthritis (RA) disease course from preclinical to established disease.

Recent Findings: ILD is a serious extra-articular manifestation of RA. Multiple studies have demonstrated a high prevalence of both subclinical and clinical ILD throughout the RA disease course. Read More

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Rheumatoid arthritis: Extra-articular manifestations and comorbidities.

Autoimmun Rev 2021 Apr 17;20(4):102776. Epub 2021 Feb 17.

Academic Rheumatology Centre, MFRU and Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Torino, Italy. Electronic address:

Although synovitis is the pathological hallmark of rheumatoid arthritis (RA), many extra-articular manifestations (EMs) and comorbidities likely occur due to the complex, chronic, inflammatory, and autoimmune features of RA. Cardiovascular (CV) disease is the most common cause of death in patients with RA. Compared to the general population, patients with RA have twice the risk of myocardial infarction and up to 50% increased CV mortality risk. Read More

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Association of P2X7 receptor genetic polymorphisms and expression with rheumatoid arthritis susceptibility in a sample of the Iranian population: a case-control study.

Clin Rheumatol 2021 Aug 12;40(8):3115-3126. Epub 2021 Feb 12.

Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Objective: Rheumatoid arthritis (RA) is a complex inflammatory autoimmune disease with joint eruption, systemic manifestation, and numerous predisposing genetic factors. The P2X7 receptor is an essential ligand-gated channel that contributes to many physiological processes, especially inflammation. However, genetic variations can alter the P2X7 receptor function. Read More

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Peripheral Ulcerative Keratitis in Rheumatoid Arthritis Patients Taking Tocilizumab: Paradoxical Manifestation or Insufficient Efficacy?

Rheumatology (Oxford) 2021 Feb 2. Epub 2021 Feb 2.

Service d'Ophtalmologie, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris-Saclay. Centre de Référence pour les maladies rares en ophtalmologie (OPHTARA), Le Kremlin-Bicêtre, France.

Objectives: Peripheral ulcerative keratitis (PUK) is a severe corneal condition associated with uncontrolled rheumatoid arthritis (RA). Tocilizumab (TCZ) is used to control RA, however, episodes of paradoxical ocular inflammation have been reported in TCZ-treated patients. We report a case series of PUK in TCZ-treated RA patients with ophthalmological and systemic findings and discuss the potential underlying mechanisms. Read More

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February 2021

Perimyocarditis as first sign of systemic onset juvenile idiopathic arthritis treated successfully with anakinra: a case-based review.

Acta Biomed 2020 09 15;91(4):ahead of print. Epub 2020 Sep 15.

Postgraduate School of Pediatrics, Department of Medical and Surgical Sciences of the Mother, Children and Adults, University of Modena and Reggio Emilia, Italy.

Background: The involvement of myocardium and pericardium at the same time is very uncommon as first manifestation of juvenile idiopathic arthritis with systemic onset (soJIA).

Case: A fourteen years-old boy, referred with symptoms of acute gastroenteritis, developed a perimyocarditis as first manifestation of  Still's Disease, after only one day from the admission. The rheumatologic disease was not responding to glucocorticoid treatment. Read More

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September 2020

Efficacy and safety of rituximab in peripheral ulcerative keratitis associated with rheumatoid arthritis.

RMD Open 2021 01;7(1)

Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin Bicêtre Hospital, Le Kremlin-Bicêtre, France.

Objective: Peripheral ulcerative keratitis (PUK) is a rare but severe ocular complication of rheumatoid arthritis (RA). It can be considered as an ocular manifestation of rheumatoid vasculitis (RV). Our case series aimed to evaluate the efficacy of rituximab (RTX) for PUK occurring in patients with RA. Read More

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January 2021

Serum Krebs von den Lungen-6 and lung ultrasound B lines as potential diagnostic and prognostic factors for rheumatoid arthritis-associated interstitial lung disease.

Clin Rheumatol 2021 Jul 21;40(7):2689-2697. Epub 2021 Jan 21.

Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Menoufia University, Shebeen El-Kom, 32511, Egypt.

Introduction: Rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) (RA-ILD) is a serious systemic RA manifestation with high mortality that needs proper, accurate, and sensitive assessment tools.

Objectives: Firstly, evaluate serum Krebs von den Lungen-6 (KL-6) levels and lung ultrasound B lines (LUS B lines) score in RA-ILD correlating them with the severity of ILD assessed by high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs). Secondly, determine cut-off values for LUS and KL-6 in RA-ILD assessment and outcome prediction. Read More

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Pain chronification and the important role of non-disease-specific symptoms in patients with systemic sclerosis.

Arthritis Res Ther 2021 01 19;23(1):34. Epub 2021 Jan 19.

Department of Rheumatology, University Hospital Zurich, University of Zurich, Gloriastrasse 25, 8091, Zurich, Switzerland.

Background: Pain is a frequent, yet inadequately explored challenge in patients with systemic sclerosis (SSc). This study aimed to conduct an extensive pain assessment, examining pain chronification and its association with disease manifestations.

Methods: Consecutive SSc patients attending their annual assessment were included. Read More

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January 2021

Uveitis as a potential predictor of acute myocardial infarction in patients with Behcet's disease: a population-based cohort study.

BMJ Open 2021 01 15;11(1):e042201. Epub 2021 Jan 15.

School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Objectives: To investigate whether uveitis is a predictor of acute myocardial infarction (AMI) among patients with Behcet's disease (BD).

Design: Retrospective cohort study.

Setting: Patients with BD were retrieved from the whole population of the Taiwan National Health Insurance Research Database from 1 January 2001 to 31 December 2013. Read More

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January 2021

Endothelial Dysfunction and Extra-Articular Neurological Manifestations in Rheumatoid Arthritis.

Biomolecules 2021 01 10;11(1). Epub 2021 Jan 10.

IRC-FSH Department of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy.

Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory autoimmune disease that affects about 1% of the global population, with a female-male ratio of 3:1. RA preferably affects the joints, with consequent joint swelling and deformities followed by ankylosis. However, evidence has accumulated showing that patients suffering from RA can also develop extra-articular manifestations, including cardiovascular disease states, neuropathies, and multiorgan dysfunction. Read More

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January 2021

Primary Sjögren's syndrome manifesting as sclerotic metabolic bone disease.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Primary Sjögren's syndrome (pSS) is a chronic slowly progressive autoimmune disease characterised by lymphocytic infiltration of salivary and lacrimal glands with varying degree of systemic involvement. Renal involvement, a recognised extraglandular manifestation of pSS, is commonly related to tubular dysfunction and generally manifests as distal renal tubular acidosis (RTA), proximal RTA, tubular proteinuria and nephrogenic diabetes insipidus. Untreated long-standing RTA is known to cause metabolic bone disease. Read More

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January 2021