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    Presence of comorbidities and prognosis of clinical symptoms in knee and/or hip osteoarthritis: A systematic review and meta-analysis.
    Semin Arthritis Rheum 2017 Oct 31. Epub 2017 Oct 31.
    Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Ghent University Hospital Campus, Building 3B3, Room 007, De Pintelaan 185, BE-9000, Ghent, Belgium; FWO (Pegasus)(2) EU Marie-Sklodowska Curie Fellow, EU Horizon 2020 Program, Brussels, Belgium. Electronic address:
    Objective: (i) To determine the association between the presence of comorbidities and severity of pain and physical dysfunction in people with knee and/or hip osteoarthritis; (ii) to explore associations between specific comorbidities (cardiac disease and/or hypertension, diabetes, depression, and back pain) and symptom severity.

    Methods: Studies were identified through systematic searches in four electronic databases and grey literature, and, subsequently, methodologically appraised. Eligible citations entailed cross-sectional or longitudinal studies as well as randomised controlled trials providing data of a direct association between comorbidity presence and the severity of self-reported and/or performance-based symptoms of pain and/or physical functioning, in people with knee and/or hip osteoarthritis. Read More

    The combination of IL-6 and its soluble receptor is associated with the response of rheumatoid arthritis patients to tocilizumab.
    Semin Arthritis Rheum 2017 Nov 17. Epub 2017 Nov 17.
    Department of Immunology, Institut de Recerca, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain. Electronic address:
    Background: IL-6 contributes significantly to the chronic inflammatory process of rheumatoid arthritis (RA). Tocilizumab, a humanized anti-human IL-6 receptor antibody that blocks the signaling originated by the IL-6/IL-6R complex, is an effective treatment. However, predictors of the response to tocilizumab are still required. Read More

    Factors associated with use of disease modifying agents for rheumatoid arthritis in the National Hospital and Ambulatory Medical Care Survey.
    Semin Arthritis Rheum 2017 Oct 18. Epub 2017 Oct 18.
    Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, 220 Arch Street, 12th Floor, Baltimore, MD 21201.
    Objective: We examined the treatment patterns among adults with rheumatoid arthritis (RA) and identified factors influencing access to traditional and biological disease modifying antirheumatic drugs (DMARDs).

    Methods: We analyzed visits recorded in the National Ambulatory Medical Care Survey from 2005 to 2014 with a RA diagnosis. The primary outcome was DMARD use (traditional and/or biological). Read More

    Sensorimotor performance and function in people with osteoarthritis of the hand: A case-control comparison.
    Semin Arthritis Rheum 2017 Sep 25. Epub 2017 Sep 25.
    Health and Rehabilitation Research Institute, Auckland University of Technology, 90 Akoranga Drive, Northcote, Auckland 0627, New Zealand; Department of Anaesthesiology and Perioperative Medicine, North Shore Hospital, Waitemata Pain Service, Waitemata DHB, Takapuna, Westlake, Auckland, New Zealand.
    Objectives: To determine whether hand left/right judgements, tactile acuity, and body perception are impaired in people with hand OA. To examine the relationships between left right judgements, tactile acuity and hand pain. To explore the relationships between sensorimotor measures (left/right judgements and tactile acuity) and measures of hand function in people with hand OA. Read More

    Carotid and femoral atherosclerosis in antiphospholipid syndrome: Equivalent risk with diabetes mellitus in a case-control study.
    Semin Arthritis Rheum 2017 Oct 23. Epub 2017 Oct 23.
    Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:
    Background: Antiphospholipid syndrome (APS) may carry a worse prognosis for vascular complications when co-existing with subclinical atherosclerosis; however, the association between the two conditions remains ambiguous.

    Methods: We evaluated ultrasonographic markers of subclinical atherosclerosis in carotid and femoral arteries of 86 patients with thrombotic APS [43 primary APS (PAPS), 43 systemic lupus erythematosus-associated APS (SLE/APS)], 86 patients with diabetes mellitus (DM) and 86 healthy controls, individually matched for age and gender, and investigated their associations with traditional and disease-related factors in APS.

    Results: Carotid plaques were found in 28% of PAPS, 23% of SLE/APS, and 30% of DM patients versus 9% of controls (p = 0. Read More

    Risk factors and clinical characteristics of deep knee infection in patients with intra-articular injections: A matched retrospective cohort analysis.
    Semin Arthritis Rheum 2017 Oct 20. Epub 2017 Oct 20.
    Department of Orthopaedics, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address:
    Background: Deep knee infection (DKI), consisting of sepsis arthritis (SA) and chronic low-grade infection (CLGI), is a rare but catastrophic adverse event that can result from intra-articular (IA) injections. The purpose of this study was to assess the risk factors for DKI and describe the clinical characteristics of DKI in patients who received IA injections.

    Methods: Fifty patients with IA injection-induced DKI who underwent surgical treatment between January 2010 and May 2016 served as cases and were matched with non-infected controls who received IA injections in a proportion of 1:5 based on age, gender, and date of admission. Read More

    Protracted febrile myalgia syndrome treated with pulse of corticosteroids.
    Semin Arthritis Rheum 2017 Oct 12. Epub 2017 Oct 12.
    Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. Electronic address:
    Objective: This study describes our 5-year experience treating protracted febrile myalgia syndrome (PFMS) with pulsed doses of corticosteroids.

    Methods: Eight patients with PFMS who received pulse corticosteroid therapy were identified from the electronic database of a tertiary pediatric medical center (2011-2016). Their clinical and laboratory data were collected. Read More

    Vitamin D and antiphospholipid syndrome: A retrospective cohort study and meta-analysis.
    Semin Arthritis Rheum 2017 Oct 12. Epub 2017 Oct 12.
    Rheumatology Department, Facultad de Medicina, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Av Valdecilla s/n, 39008 Santander, Spain. Electronic address:
    Objectives: (a) To determine serum 25-OH vitamin D (vitD) levels in primary antiphospholipid syndrome (APS) and to compare them with patients with positive antiphospholipid serology who do not meet clinical criteria for APS, and with healthy controls. (b) To analyze the association of vitD levels with both the clinical manifestations and the immunological profile of patients with primary APS. (c) To perform a meta-analysis evaluating potential differences in serum vitD levels between APS and controls as well as the frequency of vitD deficiency in APS patients. Read More

    2013 ACR/EULAR systemic sclerosis classification criteria in patients with associated pulmonary arterial hypertension.
    Semin Arthritis Rheum 2017 Oct 13. Epub 2017 Oct 13.
    Servicio de Reumatología, Hospital Universitario12 de Octubre, Universidad Complutense de Madrid, Avda de Córdoba s/n, Madrid 28041, Spain. Electronic address:
    Objective: To analyze the performance of the 1980 ACR and new 2013 ACR/EULAR criteria for systemic sclerosis (SSc) in cutaneous SSc (lcSSc) patients, especially those affected by lcSSc and pulmonary arterial hypertension (PAH).

    Methods: All patients with a clinical lcSSc diagnosis from a prospective observational SSc cohort were included. Sociodemographic and disease-related variables were collected, and PAH confirmed by right heart catheterization (RHC). Read More

    Methods for segmentation of rheumatoid arthritis bone erosions in high-resolution peripheral quantitative computed tomography (HR-pQCT).
    Semin Arthritis Rheum 2017 Sep 23. Epub 2017 Sep 23.
    Institute of Medical Physics (IMP), Friedrich-Alexander-University Erlangen-Nüremberg (FAU), Henkestrasse 91, Erlangen 91052, Germany. Electronic address:
    Objective: The comparison between different techniques to quantify the 3-dimensional size of inflammatory bone erosions in rheumatoid arthritis(RA) patients.

    Methods: Anti-cyclic citrullinated peptide antibody(ACPA) positive RA patients received high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the metacarpophalangeal joints (MCP). Erosions were measured by three different segmentation techniques: (1) manual method with calculation by half-ellipsoid formula, (2) semi-automated modified Evaluation Script for Erosions (mESE), and (3) semi-automated Medical Image Analysis Framework (MIAF) software. Read More

    Blau syndrome with good Reponses to Tocilizumab: A case report and focused literature review.
    Semin Arthritis Rheum 2017 Sep 25. Epub 2017 Sep 25.
    Department of Pharmacology, the First Affiliated Hospital of Zhengzhou University, Higher Education Institute of Open Key Clinical Laboratory of He-nan Province, Zhengzhou Henan 450052, China.
    Objectives: Blau syndrome (BS), a rare auto-inflammatory granulomatous disease, is a progressive disorder. Usually the maintenance dose of glucocorticoid may not be tapered below 15 mg per day while immunosuppressives is used. There has been some experience with biologic agents in refractory BS patients. Read More

    Relationship of knee pain to time in moderate and light physical activities: Data from Osteoarthritis Initiative.
    Semin Arthritis Rheum 2017 Oct 9. Epub 2017 Oct 9.
    Institute for Public Health and Medicine, Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, 633 St. Clair St, 20th Floor, Chicago, IL; Northwestern University Feinberg School of Medicine, Division of Rheumatology, Department of Medicine, Chicago, IL.
    Introduction: While OA literature indicates greater pain is related to less time being physically active, it is not known if time curtailment occurs primarily for moderate intensity activities or for light activities or in both. We examine the cross-sectional association of knee pain with physical activity using data from 1874 Osteoarthritis Initiative participants.

    Methods: Knee pain characteristics of constant and intermittent pain were each scored by the Intermittent and Constant Osteoarthritis Pain instrument and categorized into four pain levels (no pain, intermittent pain below and above median level, and constant pain). Read More

    The UltraSound-CLinical ARthritis Activity (US-CLARA) index: Properties of a new composite disease activity index for rheumatoid arthritis.
    Semin Arthritis Rheum 2017 Sep 28. Epub 2017 Sep 28.
    Rheumatology Unit, Catholic University of the Sacred Heart, Rome, Italy.
    Objective: To assess validity, responsiveness and interpretability of the UltraSound-CLinical ARthritis Activity (US-CLARA) index in patients with rheumatoid arthritis (RA).

    Methods: In this longitudinal study were involved RA patients starting treatment with abatacept. Subjects were followed along three visits in the first 6 months of therapy and underwent a comprehensive clinimetric evaluation. Read More

    Systematic switch from innovator infliximab to biosimilar infliximab in inflammatory chronic diseases in daily clinical practice: The experience of Cochin University Hospital, Paris, France.
    Semin Arthritis Rheum 2017 Oct 5. Epub 2017 Oct 5.
    Paris Descartes University, Sorbonne Paris Cité, INSERM U1016, Cochin Institute, CNRS UMR8104, Paris, France; INSERM U1153, Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France.
    Objective: To investigate effectiveness of systematic switching treatment from innovator infliximab to biosimilar infliximab, and its associated factors.

    Methods: In this prospective observational study, all adult patients receiving maintenance therapy with innovator infliximab in Cochin University Hospital were systematically switched to biosimilar infliximab. Effectiveness was assessed by the retention rate of biosimilar infliximab at the time of the third infusion. Read More

    Long-term outcome of 251 patients with Takayasu arteritis on combination immunosuppressant therapy: Single centre experience from a large tertiary care teaching hospital in Southern India.
    Semin Arthritis Rheum 2017 Sep 30. Epub 2017 Sep 30.
    Rheumatology Research Group, College of Medicine and Dentistry, University of Birmingham, Birmingham, UK.
    Introduction: Long-term outcome studies in Takayasu arteritis (TA) are few and limited by small sample size. In this study, we analysed the outcome of treatment in a large series of TA patients with a minimum follow-up period of ≥12 months by objective instruments.

    Materials And Methods: Patients with TA satisfying the 1990 ACR, Ishikawa's, Sharma's or EULAR/PRESS criteria were recruited from our clinics between 1998 and 2016. Read More

    A randomized trial of a motivational interviewing intervention to increase lifestyle physical activity and improve self-reported function in adults with arthritis.
    Semin Arthritis Rheum 2017 Oct 5. Epub 2017 Oct 5.
    Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Institute of Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL; Shirley Ryan AbilityLab, Chicago, IL. Electronic address:
    Background: Arthritis is a leading cause of chronic pain and functional limitations. Exercise is beneficial for improving strength and function and decreasing pain. We evaluated the effect of a motivational interviewing-based lifestyle physical activity intervention on self-reported physical function in adults with knee osteoarthritis (KOA) or rheumatoid arthritis (RA). Read More

    Outcomes of lupus and rheumatoid arthritis patients with primary dengue infection: A seven-year report from Brazil.
    Semin Arthritis Rheum 2017 Sep 8. Epub 2017 Sep 8.
    Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA.
    Objective: We described the clinical profile and outcomes of patients with SLE and RA diseases reported to the Brazilian Health Information System with primary dengue infection.

    Methods: Databases from the Brazilian Public Health Informatics System (SUS) were linked as the source of information. Three databases comprising different longitudinal information of lupus or rheumatoid arthritis (RA) patients under treatment and care through the Brazilian Health System were linked. Read More

    International patellofemoral osteoarthritis consortium: Consensus statement on the diagnosis, burden, outcome measures, prognosis, risk factors and treatment.
    Semin Arthritis Rheum 2017 Sep 23. Epub 2017 Sep 23.
    Department of General Practice, Erasmus MC University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands; Department of Orthopaedic Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
    Objective: To present the current status of knowledge in the field of patellofemoral (PF) osteoarthritis (OA) and formulate a research agenda in order to guide future research on this topic.

    Design: A 1-day meeting was organized with the aim to bring together international experts in the field to discuss the current state of knowledge on PF OA. Experts from multiple disciplines were invited based on their scientific publications in the field of PF OA and interest in the subject. Read More

    Association between NICE guidance on biologic therapies with rates of hip and knee replacement among rheumatoid arthritis patients in England and Wales: An interrupted time-series analysis.
    Semin Arthritis Rheum 2017 Sep 23. Epub 2017 Sep 23.
    Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD; GREMPAL Research Group, Idiap Jordi Gol Primary Care Research Institute and CIBERFes, Universitat Autònoma de Barcelona and Instituto de Salud Carlos III, Barcelona, Spain. Electronic address:
    Objective: To estimate the impact of NICE approval of tumor necrosis factor inhibitor (TNFi) therapies on the incidence of total hip replacement (THR) and total knee replacement (TKR) among rheumatoid arthritis (RA) patients in England and Wales.

    Methods: Primary care data [Clinical Practice Research Datalink (CPRD)] for the study period (1995-2014) were used to identify incident adult RA patients. The age and sex-standardised 5-year incidence of THR and TKR was calculated separately for RA patients diagnosed in each six-months between 1995-2009. Read More

    Diagnostic accuracy of ultrasound in patients with gout: A meta-analysis.
    Semin Arthritis Rheum 2017 Sep 28. Epub 2017 Sep 28.
    Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University Medical Center, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Korea.
    Objective: This study aimed to evaluate the diagnostic performance of ultrasound (US) for patients with gout.

    Methods: We searched the Medline, Embase, Pubmed, and Cochrane Library databases, and performed a meta-analysis of the diagnostic accuracy of US according to the double contour sign, tophus, snowstorm, or bony erosion in patients with gout.

    Results: In total, 11 studies including 938 patients with gout, and 788 controls (patients with nongout inflammatory arthritis) were available for the meta-analysis. Read More

    T-regulatory cells-Triumph of perseverance: The Crafoord Prize for Polyarthritis in 2017.
    Semin Arthritis Rheum 2017 Sep 6. Epub 2017 Sep 6.
    Department of Clinical Sciences, Lund, Rheumatology, Lund University, Lund, Sweden. Electronic address:
    The Crafoord Prize in Polyarthritis ranks as one of the most prestigious prizes and can be awarded only if the Royal Swedish Academy of Sciences decides the likelihood of prize worthy progress in the field, and at most every 4th year. This has happened only four times since 1982. This year the 5th Laureates were Shimon Sakaguchi, Fred Ramsdell, and Alexander Rudensky with the motivation "for their discoveries relating to regulatory T cells, which counteract harmful immune reactions in arthritis and other autoimmune diseases". Read More

    A systematic review of measurement properties of patient reported outcome measures in psoriatic arthritis: A GRAPPA-OMERACT initiative.
    Semin Arthritis Rheum 2017 Sep 9. Epub 2017 Sep 9.
    The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Nordre Fasanvej 57, DK-2000, Copenhagen, Denmark. Electronic address:
    Background: An updated psoriatic arthritis (PsA) core outcome set (COS) for randomized controlled trials (RCTs) was endorsed at the Outcome Measures in Rheumatology (OMERACT) meeting in 2016.

    Objectives: To synthesize the evidence on measurement properties of patient reported outcome measures (PROMs) for PsA and thereby contribute to development of a PsA core outcome measurement set (COMS) as described by the OMERACT Filter 2.0. Read More

    Rheumatoid arthritis and risk of chronic obstructive pulmonary disease or asthma among women: A marginal structural model analysis in the Nurses' Health Study.
    Semin Arthritis Rheum 2017 Sep 18. Epub 2017 Sep 18.
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
    Objective: We investigated whether RA increases risk for chronic obstructive pulmonary disease (COPD) or asthma independent of factors occurring before RA onset or mediating these respiratory morbidities after diagnosis, such as cigarette smoking.

    Methods: Within the prospective Nurses' Health Study (n = 121,701 women; 1976-2014), we identified an incident RA cohort and matched each woman with RA to 10 comparators without RA by age and year at index date of RA diagnosis, excluding women with COPD or asthma at baseline. Data were obtained through biennial questionnaires and medical records. Read More

    (18)F-FDG PET/CT in the follow-up of large-vessel vasculitis: A study of 37 consecutive patients.
    Semin Arthritis Rheum 2017 Aug 31. Epub 2017 Aug 31.
    Department of Nuclear Medicine, Hospital Universitario Marqués de Valdecilla, Molecular Imaging Group (IDIVAL), Santander, Spain; School of Medicine, University of Cantabria, Santander, Spain.
    Objective: (18)F-FDG PET/CT has proved to be of potential value for early diagnosis of large-vessel vasculitis (LVV), which frequently involves the aorta. However, its role in the follow-up of these patients has not been well established. Our aim was to evaluate the contribution of (18)F-FDG PET/CT in this clinical situation. Read More

    The value of (18)F-FDG PET/CT in the distinction between retroperitoneal fibrosis and its malignant mimics.
    Semin Arthritis Rheum 2017 Aug 3. Epub 2017 Aug 3.
    Department of Rheumatology, Chinese PLA General Hospital, Beijing, China. Electronic address:
    Objective: To discuss the utility of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) in the diagnosis of idiopathic retroperitoneal fibrosis (iRPF).

    Methods: IRPF patients diagnosed between September 2011 and June 2016 were included. Retroperitoneal malignancy patients were included as control. Read More

    Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: New evidence from real-world data.
    Semin Arthritis Rheum 2017 Aug 3. Epub 2017 Aug 3.
    Genentech, A Member of Roche Group, San Fransisco, CA.
    Background: To evaluate the impact of treatment with disease-modifying antirheumatic drugs (DMARDs), including IL-6 receptor inhibitor tocilizumab (TCZ), on anaemia markers in patients with rheumatoid arthritis.

    Methods: Using the Centricity Electronic Medical Records from USA, patients with rheumatoid arthritis diagnosed between January 2000 and April 2016, who initiated TCZ (n = 3732); tofacitinib (TOFA, n = 3126); other biologic DMARD (obDMARD, n = 55,964); or other non-biologic DMARD (onbDMARD, n = 91,236) were identified. Changes in haemoglobin (Hb) and haematocrit (Hct) over 2 years of treatment initiation were evaluated, adjusting and balancing for confounders. Read More

    Influence of obesity, age, and comorbidities on the multi-biomarker disease activity test in rheumatoid arthritis.
    Semin Arthritis Rheum 2017 Aug 2. Epub 2017 Aug 2.
    Corrona Research Foundation, Albany, NY.
    Introduction: Traditional markers of inflammation are often required for inclusion in rheumatoid arthritis trials, yet patients with active disease may have normal lab tests. The potential use of the multi-biomarker disease activity (MBDA) test in this setting is unclear, as is understanding of whether it is influenced by patient characteristics (e.g. Read More

    Race, sex, and risk factors in radiographic worsening of knee osteoarthritis.
    Semin Arthritis Rheum 2017 Aug 31. Epub 2017 Aug 31.
    Division of Rheumatology, Department of Medicine, University of Arizona, Tucson, AZ; Arizona Arthritis Center, University of Arizona, Tucson, AZ.
    Objectives: Characterize radiographic worsening in knee osteoarthritis (KOA) by race and sex over 4 years and evaluate the role of established risk factors in observed race/sex differences.

    Methods: Whites (WHs) (694 males and 929 females) and African-Americans (AAs) (92 males and 167 females) at risk for radiographic KOA were eligible. Cox shared frailty models were used to estimate race and sex group differences in radiographic worsening, defined by Kellgren-Lawrence (K-L) and OARSI joint space narrowing (JSN). Read More

    Persistence of biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: An analysis of the South Korean National Health Insurance Database.
    Semin Arthritis Rheum 2017 Aug 31. Epub 2017 Aug 31.
    School of Pharmacy, Sungkyunkwan University, Suwon, South Korea. Electronic address:
    Objectives: This study examined and compared the persistence of adalimumab, etanercept, infliximab, or abatacept as first- and subsequent-line treatment for rheumatoid arthritis in the South Korean clinical practice.

    Methods: We conducted a retrospective cohort study with patients receiving adalimumab, etanercept, infliximab, or abatacept between July 1, 2009 and December 31, 2012, using the nationwide Korean National Health Insurance database. Patients who were receiving a newly initiated biologic treatment and those who switched from other biologic treatment were identified and classified into first- and subsequent-use cohorts, respectively. Read More

    Healthcare utilization and expenditures for United States Medicare beneficiaries with systemic vasculitis.
    Semin Arthritis Rheum 2017 Aug 10. Epub 2017 Aug 10.
    UNC Kidney Center and Division of Nephrology & Hypertension, University of North Carolina School of Medicine, 7009 Burnett-Womack, Chapel Hill, NC 27599.
    Objective: The Medicare federal insurance program is the most common United States insurer of patients with systemic vasculitis (SV). We compared healthcare utilization and expenditures for Medicare beneficiaries with versus without SV.

    Methods: This national, retrospective study used 2010 claims and enrollment data for a 100% cohort of Medicare Part A and B beneficiaries with ≥1 claim including a diagnosis for a form of SV (n = 176,498), and a randomly selected group of non-SV beneficiaries (n = 46,561). Read More

    The BVAS is an independent predictor of cardiovascular events and cardiovascular disease-related mortality in patients with ANCA-associated vasculitis: A study of 504 cases in a single Chinese center.
    Semin Arthritis Rheum 2017 Aug 31. Epub 2017 Aug 31.
    Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Peking-Tsinghua Center for Life Sciences, Beijing, P.R. China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, P.R. China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, P.R. China.
    Background: Cardiovascular diseases (CVD) are the major causes of death in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during long-term follow-up. This study investigated risk factors for cardiovascular events (CVE) and CVD-related mortality in Chinese AAV patients.

    Methods: Five hundred and four AAV patients in our center were retrospectively included. Read More

    Toward classification criteria for early osteoarthritis of the knee.
    Semin Arthritis Rheum 2017 Aug 9. Epub 2017 Aug 9.
    Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
    Objective: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting.

    Methods: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions around relevant topics with short state of the art presentations followed by breakout sessions, consensus discussions, and consolidation into a consensus document. Read More

    Equivalence in the Health Assessment Questionnaire (HAQ) across socio-demographic determinants: Analyses within QUEST-RA.
    Semin Arthritis Rheum 2017 Aug 9. Epub 2017 Aug 9.
    CAPHRI Research Institute, Maastricht University, Maastricht, the Netherlands.
    Objectives: To investigate potential bias in scores of the Health Assessment Questionnaire (HAQ) related to socio-demographic (SD) background of patients with rheumatoid arthritis (RA).

    Methods: Data from the Quantitative Standard Monitoring of Rheumatoid Arthritis study (QUEST-RA), comprising 9022 patients were analysed. Physical function was assessed through 30 items of four HAQ versions: the HAQ-Disability scale, HAQ-II, modified HAQ and multi-dimensional HAQ (MD-HAQ). Read More

    Inflammatory myopathy associated with anti-mitochondrial antibodies: A distinct phenotype with cardiac involvement.
    Semin Arthritis Rheum 2017 Jun 13. Epub 2017 Jun 13.
    Division of Rheumatology, Johns Hopkins University, School of Medicine, Baltimore, MD. Electronic address:
    Objective: In the context of clinical evaluations performed on our prospective myositis cohort, we noted a striking association of severe cardiac disease in myositis patients with anti-mitochondrial antibodies. We sought to review all cases of anti-mitochondrial antibody (AMA) associated myositis in our cohort to describe the clinical features of this disease subset.

    Methods: We identified 7 patients with confirmed anti-mitochondrial antibodies who presented as an inflammatory myopathy. Read More

    Effect of complete or partial proteinuria recovery on long-term outcomes of lupus nephritis.
    Semin Arthritis Rheum 2017 Aug 3. Epub 2017 Aug 3.
    Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto Lupus Clinic, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8. Electronic address:
    Background/purpose: We aimed to evaluate the effect of complete recovery (CR), partial recovery (PR), and no recovery (NR) of proteinuria at 2 years from the diagnosis of LN on long-term renal and extra-renal outcomes.

    Methods: Patients with LN and proteinuria attending the Lupus Center from 1970 to 2015 were analyzed. At 2 years from diagnosis of LN, patients were divided into three groups (CR, PR, and NR), and long-term outcomes were studied up to 15 years or last visit available. Read More

    Esophageal baseline impedance levels allow the identification of esophageal involvement in patients with systemic sclerosis.
    Semin Arthritis Rheum 2017 Aug 9. Epub 2017 Aug 9.
    Division of Gastroenterology, Departement of Surgery, Oncology and Gastroenterology, Gastroenterology Unit, University of Padua, Via Giustiniani 2, 35128 Padova, Italy. Electronic address:
    Introduction: Distal esophageal baseline impedance (BI) levels reflect the esophageal mucosal integrity in reflux disease. Systemic sclerosis (SSc) could potentially affect the integrity of esophageal mucosa and consequently impair distal and proximal BI levels, but data in this regard are lacking.

    Aim And Methods: We aimed to prospectively investigate and compare BI levels among non-erosive reflux disease (NERD), SSc patients, and healthy controls (HCs). Read More

    Impact of anti-rheumatic treatment on cardiovascular risk in Asian patients with rheumatoid arthritis.
    Semin Arthritis Rheum 2017 Aug 3. Epub 2017 Aug 3.
    Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea. Electronic address:
    Objectives: To estimate the incidence of cardiovascular disease (CVD) in Asian patients with rheumatoid arthritis (RA) and to evaluate the impact of anti-rheumatic treatment on the development of CVD.

    Methods: A retrospective cohort of Asian patients with RA was established to identify the incidence rate (IR) of CVD in RA patients. The cohort was generated using the Korean National Healthcare claims database, which contained claims from Jan 2009 to Dec 2013. Read More

    Mortality causes and outcomes in Indigenous populations of Canada, the United States, and Australia with rheumatic disease: A systematic review.
    Semin Arthritis Rheum 2017 Jul 25. Epub 2017 Jul 25.
    Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:
    Background: Indigenous populations of Canada, America, Australia, and New Zealand have increased rates and severity of rheumatic disease. Our objective was to summarize mortality outcomes and explore disease and social factors related to mortality.

    Methods: A systematic search was performed in medical (Medline, EMBASE, and CINAHL), Indigenous and conference abstract databases (to June 2015) combining search terms for Indigenous populations and rheumatic diseases. Read More

    Tubulointerstitial damage predicts end stage renal disease in lupus nephritis with preserved to moderately impaired renal function: A retrospective cohort study.
    Semin Arthritis Rheum 2017 Jul 14. Epub 2017 Jul 14.
    Division of Rheumatology, Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
    Objectives: The presence of tubulointerstitial damage (TID) on renal biopsy is considered to be a late sequela of lupus nephritis (LN). The objective of this study was to determine if TID predicts progression to end stage renal disease (ESRD) in LN patients without advanced kidney disease.

    Methods: All SLE patients with an index biopsy consistent with LN between January 2005 and July 2015, and eGFR ≥ 30mL/min/1. Read More

    The psychosocial burden of psoriatic arthritis.
    Semin Arthritis Rheum 2017 Dec 20;47(3):351-360. Epub 2017 May 20.
    Cleveland Clinic, Main Campus, 9500 Euclid Ave, Cleveland, OH 44195.
    Objective: To assess the psychosocial impact of psoriatic arthritis (PsA), describe how health-related quality of life (QoL) is affected in patients with PsA, discuss measures used to evaluate the psychosocial impact of PsA, and review studies examining the effect of therapy on QoL.

    Methods: A targeted review on the impact of PsA on QoL and the role of tailored psychosocial management in reducing the psychosocial burden of the disease was performed. PubMed literature searches were conducted using the terms PsA, psychosocial burden, QoL, and mood/behavioral changes. Read More

    Catastrophic antiphospholipid syndrome (CAPS)-induced ischemic pancreatic ducts injury mimicking intraductal papillary mucinous neoplasm (IPMN).
    Semin Arthritis Rheum 2017 Jul 10. Epub 2017 Jul 10.
    Université Paris-Descartes, Paris, France; AP-HP, Hôpital Cochin, Centre de référence des maladies auto-immunes et systémiques rares, Service de Médecine Interne, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; INSERM U 1153, Center for Epidemiology and Statistics, Sorbonne Paris Cité (CRESS) Paris, France. Electronic address:
    Objectives: Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening disease characterized by multiple small-vessel occlusions of rapid onset. Ischemic pancreatic duct lesions secondary to CAPS have never been reported.

    Methods: We describe 4 patients who presented lesions suspected to be intraductal papillary mucinous neoplasm (IPMN) of the pancreas following a CAPS. Read More

    Adult's onset Still disease occurring during pregnancy: Case-report and literature review.
    Semin Arthritis Rheum 2017 Jul 10. Epub 2017 Jul 10.
    Service de Médecine Interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), AP-HP, Hôpital Saint-Antoine, Sorbonne Universités, UPMC University Paris 06, F-75012, Paris, France.
    Introduction: Adult onset Still's disease is a rare affection classified among non-hereditary autoinflammatory diseases. We here report a case of AOSD revealed during pregnancy with a life-threatening presentation along with a review of 19 cases from literature.

    Case: A 38-years old woman was treated in our department for diffuse systemic sclerosis and associated Sjögren syndrome. Read More

    Efficacy of intralesional sodium thiosulfate injections for disabling tumoral calcinosis: Two cases.
    Semin Arthritis Rheum 2017 Dec 17;47(3):451-455. Epub 2017 Jun 17.
    Service de pédiatrie, Hopital de la Mère et de l'Enfant, Limoges, France. Electronic address:
    Introduction: Tumoral calcinosis (TC) is a difficult-to-treat complication that can occur during several diseases such as dermatomyositis or genetic hyperphosphatemia. It is a painful and disabling condition that can lead to local complications including joint mobility reduction, cutaneous ulceration and superinfection. For the largest lesions, the treatment relies essentially on surgery. Read More

    Validation of the Fautrel classification criteria for adult-onset Still's disease.
    Semin Arthritis Rheum 2017 Jul 12. Epub 2017 Jul 12.
    Department of Rheumatology, APHP, Pitié-Salpêtrière Hospital, Paris, France; Université Pierre et Marie Curie (UPMC), GRC 08, Pierre Louis Institute of Epidemiology and Public Health, Paris, France. Electronic address:
    Objectives: To validate the Fautrel classification criteria for adult-onset Still's disease (AOSD) and to compare the discriminative performance to that of the Yamaguchi criteria.

    Methods: We retrospectively reviewed the medical charts of 426 patients who had serum ferritin level and percentage glycosylated ferritin assayed at the biochemistry laboratory of Bichat Hospital. Medical data were extracted by use of a standardized form. Read More

    Adult onset Still's disease-The evidence that anti-interleukin-1 treatment is effective and well-tolerated (a comprehensive literature review).
    Semin Arthritis Rheum 2017 Oct 23;47(2):295-302. Epub 2017 Jun 23.
    Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin, Berlin, Germany.
    The literature contains many reports of the use of commercially available anti-IL-1 agents (anakinra/Kineret(®), canakinumab/Ilaris(®), or rilonacept/Arcalyst(®)) in treatment-resistant adult-onset Still's disease (AOSD). These have been widely summarized in many review articles, but a full account of all reports with each of the agents used is not available. This literature review includes all reports of treatment outcomes in patients treated for AOSD with any commercially available anti-IL-1 agent (excluding cases of unconfirmed or atypical AOSD or treatments only for rare AOSD complications). Read More

    Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort.
    Semin Arthritis Rheum 2017 Jun 23. Epub 2017 Jun 23.
    Copenhagen Lupus and Vasculitis Clinic, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
    Objective: To determine the concordance of systemic lupus erythematosus (SLE) and co-aggregating autoimmune diseases among Danish twins.

    Methods: SLE-affected twins were ascertained by record linkage between the National Patient Register (NPR) and the Danish Twin Registry (DTR). Registered SLE codes were validated through medical chart review and information from the treating physicians. Read More

    Multivariate pattern analysis utilizing structural or functional MRI-In individuals with musculoskeletal pain and healthy controls: A systematic review.
    Semin Arthritis Rheum 2017 Dec 15;47(3):418-431. Epub 2017 Jun 15.
    Recover Injury Research Centre, NHMRC CRE in Recovery Following Road Traffic Injury, Menzies Health Institute QLD, Griffith University, Gold Coast Campus, Southport, Queensland 4125, Australia.
    Objective: The purpose of this systematic review is to systematically review the evidence relating to findings generated by multivariate pattern analysis (MVPA) following structural or functional magnetic resonance imaging (fMRI) to determine if this analysis is able to: a) Discriminate between individuals with musculoskeletal pain and healthy controls, b) Predict pain perception in healthy individuals stimulated with a noxious stimulus compared to those stimulated with a non-noxious stimulus.

    Methods: MEDLINE, CINAHL, Embase, PEDro, Google Scholar, Cochrane library and Web of Science were systematically screened for relevant literature using different combinations of keywords regarding structural and functional MRI analysed with MVPA, both in individuals with musculoskeletal pain and healthy controls. Reference lists of included articles were hand-searched for additional literature. Read More

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