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    19056 results match your criteria Arthritis and rheumatism[Journal]

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    Race, sex, and risk factors in radiographic worsening of knee osteoarthritis.
    Semin Arthritis Rheum 2017 Aug 31. Epub 2017 Aug 31.
    Division of Rheumatology, Department of Medicine, University of Arizona, Tucson, AZ; Arizona Arthritis Center, University of Arizona, Tucson, AZ.
    Objectives: Characterize radiographic worsening in knee osteoarthritis (KOA) by race and sex over 4 years and evaluate the role of established risk factors in observed race/sex differences.

    Methods: Whites (WHs) (694 males and 929 females) and African-Americans (AAs) (92 males and 167 females) at risk for radiographic KOA were eligible. Cox shared frailty models were used to estimate race and sex group differences in radiographic worsening, defined by Kellgren-Lawrence (K-L) and OARSI joint space narrowing (JSN). Read More

    Persistence of biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: An analysis of the South Korean National Health Insurance Database.
    Semin Arthritis Rheum 2017 Aug 31. Epub 2017 Aug 31.
    School of Pharmacy, Sungkyunkwan University, Suwon, South Korea. Electronic address:
    Objectives: This study examined and compared the persistence of adalimumab, etanercept, infliximab, or abatacept as first- and subsequent-line treatment for rheumatoid arthritis in the South Korean clinical practice.

    Methods: We conducted a retrospective cohort study with patients receiving adalimumab, etanercept, infliximab, or abatacept between July 1, 2009 and December 31, 2012, using the nationwide Korean National Health Insurance database. Patients who were receiving a newly initiated biologic treatment and those who switched from other biologic treatment were identified and classified into first- and subsequent-use cohorts, respectively. Read More

    Healthcare utilization and expenditures for United States Medicare beneficiaries with systemic vasculitis.
    Semin Arthritis Rheum 2017 Aug 10. Epub 2017 Aug 10.
    UNC Kidney Center and Division of Nephrology & Hypertension, University of North Carolina School of Medicine, 7009 Burnett-Womack, Chapel Hill, NC 27599.
    Objective: The Medicare federal insurance program is the most common United States insurer of patients with systemic vasculitis (SV). We compared healthcare utilization and expenditures for Medicare beneficiaries with versus without SV.

    Methods: This national, retrospective study used 2010 claims and enrollment data for a 100% cohort of Medicare Part A and B beneficiaries with ≥1 claim including a diagnosis for a form of SV (n = 176,498), and a randomly selected group of non-SV beneficiaries (n = 46,561). Read More

    The BVAS is an independent predictor of cardiovascular events and cardiovascular disease-related mortality in patients with ANCA-associated vasculitis: A study of 504 cases in a single Chinese center.
    Semin Arthritis Rheum 2017 Aug 31. Epub 2017 Aug 31.
    Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Peking-Tsinghua Center for Life Sciences, Beijing, P.R. China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, P.R. China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing, P.R. China.
    Background: Cardiovascular diseases (CVD) are the major causes of death in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during long-term follow-up. This study investigated risk factors for cardiovascular events (CVE) and CVD-related mortality in Chinese AAV patients.

    Methods: Five hundred and four AAV patients in our center were retrospectively included. Read More

    Toward classification criteria for early osteoarthritis of the knee.
    Semin Arthritis Rheum 2017 Aug 9. Epub 2017 Aug 9.
    Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
    Objective: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting.

    Methods: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions around relevant topics with short state of the art presentations followed by breakout sessions, consensus discussions, and consolidation into a consensus document. Read More

    Equivalence in the Health Assessment Questionnaire (HAQ) across socio-demographic determinants: Analyses within QUEST-RA.
    Semin Arthritis Rheum 2017 Aug 9. Epub 2017 Aug 9.
    CAPHRI Research Institute, Maastricht University, Maastricht, the Netherlands.
    Objectives: To investigate potential bias in scores of the Health Assessment Questionnaire (HAQ) related to socio-demographic (SD) background of patients with rheumatoid arthritis (RA).

    Methods: Data from the Quantitative Standard Monitoring of Rheumatoid Arthritis study (QUEST-RA), comprising 9022 patients were analysed. Physical function was assessed through 30 items of four HAQ versions: the HAQ-Disability scale, HAQ-II, modified HAQ and multi-dimensional HAQ (MD-HAQ). Read More

    Inflammatory myopathy associated with antimitochondrial antibodies: A distinct phenotype with cardiac involvement.
    Semin Arthritis Rheum 2017 Jun 13. Epub 2017 Jun 13.
    Department of Medicine, Division of Rheumatology, Johns Hopkins University, School of Medicine, Baltimore, MD. Electronic address:
    Objective: In the context of clinical evaluations performed on our prospective myositis cohort, we noted a striking association of severe cardiac disease in myositis patients with antimitochondrial antibodies. We sought to review all cases of antimitochondrial antibody (AMA) associated myositis in our cohort to describe the clinical features of this disease subset.

    Methods: We identified 7 patients with confirmed antimitochondrial antibodies who presented as an inflammatory myopathy. Read More

    Effect of complete or partial proteinuria recovery on long-term outcomes of lupus nephritis.
    Semin Arthritis Rheum 2017 Aug 3. Epub 2017 Aug 3.
    Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto Lupus Clinic, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8. Electronic address:
    Background/purpose: We aimed to evaluate the effect of complete recovery (CR), partial recovery (PR), and no recovery (NR) of proteinuria at 2 years from the diagnosis of LN on long-term renal and extra-renal outcomes.

    Methods: Patients with LN and proteinuria attending the Lupus Center from 1970 to 2015 were analyzed. At 2 years from diagnosis of LN, patients were divided into three groups (CR, PR, and NR), and long-term outcomes were studied up to 15 years or last visit available. Read More

    Esophageal baseline impedance levels allow the identification of esophageal involvement in patients with systemic sclerosis.
    Semin Arthritis Rheum 2017 Aug 9. Epub 2017 Aug 9.
    Division of Gastroenterology, Departement of Surgery, Oncology and Gastroenterology, Gastroenterology Unit, University of Padua, Via Giustiniani 2, 35128 Padova, Italy. Electronic address:
    Introduction: Distal esophageal baseline impedance (BI) levels reflect the esophageal mucosal integrity in reflux disease. Systemic sclerosis (SSc) could potentially affect the integrity of esophageal mucosa and consequently impair distal and proximal BI levels, but data in this regard are lacking.

    Aim And Methods: We aimed to prospectively investigate and compare BI levels among non-erosive reflux disease (NERD), SSc patients, and healthy controls (HCs). Read More

    Impact of anti-rheumatic treatment on cardiovascular risk in Asian patients with rheumatoid arthritis.
    Semin Arthritis Rheum 2017 Aug 3. Epub 2017 Aug 3.
    Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea. Electronic address:
    Objectives: To estimate the incidence of cardiovascular disease (CVD) in Asian patients with rheumatoid arthritis (RA) and to evaluate the impact of anti-rheumatic treatment on the development of CVD.

    Methods: A retrospective cohort of Asian patients with RA was established to identify the incidence rate (IR) of CVD in RA patients. The cohort was generated using the Korean National Healthcare claims database, which contained claims from Jan 2009 to Dec 2013. Read More

    Mortality causes and outcomes in Indigenous populations of Canada, the United States, and Australia with rheumatic disease: A systematic review.
    Semin Arthritis Rheum 2017 Jul 25. Epub 2017 Jul 25.
    Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:
    Background: Indigenous populations of Canada, America, Australia, and New Zealand have increased rates and severity of rheumatic disease. Our objective was to summarize mortality outcomes and explore disease and social factors related to mortality.

    Methods: A systematic search was performed in medical (Medline, EMBASE, and CINAHL), Indigenous and conference abstract databases (to June 2015) combining search terms for Indigenous populations and rheumatic diseases. Read More

    Tubulointerstitial damage predicts end stage renal disease in lupus nephritis with preserved to moderately impaired renal function: A retrospective cohort study.
    Semin Arthritis Rheum 2017 Jul 14. Epub 2017 Jul 14.
    Division of Rheumatology, Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
    Objectives: The presence of tubulointerstitial damage (TID) on renal biopsy is considered to be a late sequela of lupus nephritis (LN). The objective of this study was to determine if TID predicts progression to end stage renal disease (ESRD) in LN patients without advanced kidney disease.

    Methods: All SLE patients with an index biopsy consistent with LN between January 2005 and July 2015, and eGFR ≥ 30mL/min/1. Read More

    The psychosocial burden of psoriatic arthritis.
    Semin Arthritis Rheum 2017 May 20. Epub 2017 May 20.
    Cleveland Clinic, Main Campus, 9500 Euclid Ave, Cleveland, OH 44195.
    Objective: To assess the psychosocial impact of psoriatic arthritis (PsA), describe how health-related quality of life (QoL) is affected in patients with PsA, discuss measures used to evaluate the psychosocial impact of PsA, and review studies examining the effect of therapy on QoL.

    Methods: A targeted review on the impact of PsA on QoL and the role of tailored psychosocial management in reducing the psychosocial burden of the disease was performed. PubMed literature searches were conducted using the terms PsA, psychosocial burden, QoL, and mood/behavioral changes. Read More

    Catastrophic antiphospholipid syndrome (CAPS)-induced ischemic pancreatic ducts injury mimicking intraductal papillary mucinous neoplasm (IPMN).
    Semin Arthritis Rheum 2017 Jul 10. Epub 2017 Jul 10.
    Université Paris-Descartes, Paris, France; AP-HP, Hôpital Cochin, Centre de référence des maladies auto-immunes et systémiques rares, Service de Médecine Interne, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; INSERM U 1153, Center for Epidemiology and Statistics, Sorbonne Paris Cité (CRESS) Paris, France. Electronic address:
    Objectives: Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening disease characterized by multiple small-vessel occlusions of rapid onset. Ischemic pancreatic duct lesions secondary to CAPS have never been reported.

    Methods: We describe 4 patients who presented lesions suspected to be intraductal papillary mucinous neoplasm (IPMN) of the pancreas following a CAPS. Read More

    Adult's onset Still disease occurring during pregnancy: Case-report and literature review.
    Semin Arthritis Rheum 2017 Jul 10. Epub 2017 Jul 10.
    Service de Médecine Interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), AP-HP, Hôpital Saint-Antoine, Sorbonne Universités, UPMC University Paris 06, F-75012, Paris, France.
    Introduction: Adult onset Still's disease is a rare affection classified among non-hereditary autoinflammatory diseases. We here report a case of AOSD revealed during pregnancy with a life-threatening presentation along with a review of 19 cases from literature.

    Case: A 38-years old woman was treated in our department for diffuse systemic sclerosis and associated Sjögren syndrome. Read More

    Efficacy of intralesional sodium thiosulfate injections for disabling tumoral calcinosis: Two cases.
    Semin Arthritis Rheum 2017 Jun 17. Epub 2017 Jun 17.
    Service de pédiatrie, Hopital de la Mère et de l'Enfant, Limoges, France. Electronic address:
    Introduction: Tumoral calcinosis (TC) is a difficult-to-treat complication that can occur during several diseases such as dermatomyositis or genetic hyperphosphatemia. It is a painful and disabling condition that can lead to local complications including joint mobility reduction, cutaneous ulceration and superinfection. For the largest lesions, the treatment relies essentially on surgery. Read More

    Validation of the Fautrel classification criteria for adult-onset Still's disease.
    Semin Arthritis Rheum 2017 Jul 12. Epub 2017 Jul 12.
    Department of Rheumatology, APHP, Pitié-Salpêtrière Hospital, Paris, France; Université Pierre et Marie Curie (UPMC), GRC 08, Pierre Louis Institute of Epidemiology and Public Health, Paris, France. Electronic address:
    Objectives: To validate the Fautrel classification criteria for adult-onset Still's disease (AOSD) and to compare the discriminative performance to that of the Yamaguchi criteria.

    Methods: We retrospectively reviewed the medical charts of 426 patients who had serum ferritin level and percentage glycosylated ferritin assayed at the biochemistry laboratory of Bichat Hospital. Medical data were extracted by use of a standardized form. Read More

    Adult onset Still's disease-The evidence that anti-interleukin-1 treatment is effective and well-tolerated (a comprehensive literature review).
    Semin Arthritis Rheum 2017 Jun 23. Epub 2017 Jun 23.
    Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin, Berlin, Germany.
    The literature contains many reports of the use of commercially available anti-IL-1 agents (anakinra/Kineret(®), canakinumab/Ilaris(®), or rilonacept/Arcalyst(®)) in treatment-resistant adult-onset Still's disease (AOSD). These have been widely summarized in many review articles, but a full account of all reports with each of the agents used is not available. This literature review includes all reports of treatment outcomes in patients treated for AOSD with any commercially available anti-IL-1 agent (excluding cases of unconfirmed or atypical AOSD or treatments only for rare AOSD complications). Read More

    Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort.
    Semin Arthritis Rheum 2017 Jun 23. Epub 2017 Jun 23.
    Copenhagen Lupus and Vasculitis Clinic, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
    Objective: To determine the concordance of systemic lupus erythematosus (SLE) and co-aggregating autoimmune diseases among Danish twins.

    Methods: SLE-affected twins were ascertained by record linkage between the National Patient Register (NPR) and the Danish Twin Registry (DTR). Registered SLE codes were validated through medical chart review and information from the treating physicians. Read More

    Multivariate pattern analysis utilizing structural or functional MRI-In individuals with musculoskeletal pain and healthy controls: A systematic review.
    Semin Arthritis Rheum 2017 Jun 15. Epub 2017 Jun 15.
    Recover Injury Research Centre, NHMRC CRE in Recovery Following Road Traffic Injury, Menzies Health Institute QLD, Griffith University, Gold Coast Campus, Southport, Queensland 4125, Australia.
    Objective: The purpose of this systematic review is to systematically review the evidence relating to findings generated by multivariate pattern analysis (MVPA) following structural or functional magnetic resonance imaging (fMRI) to determine if this analysis is able to: a) Discriminate between individuals with musculoskeletal pain and healthy controls, b) Predict pain perception in healthy individuals stimulated with a noxious stimulus compared to those stimulated with a non-noxious stimulus.

    Methods: MEDLINE, CINAHL, Embase, PEDro, Google Scholar, Cochrane library and Web of Science were systematically screened for relevant literature using different combinations of keywords regarding structural and functional MRI analysed with MVPA, both in individuals with musculoskeletal pain and healthy controls. Reference lists of included articles were hand-searched for additional literature. Read More

    Incidence, mortality, and causes of death in physician-diagnosed primary Sjögren's syndrome in Korea: A nationwide, population-based study.
    Semin Arthritis Rheum 2017 Mar 8. Epub 2017 Mar 8.
    Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. Electronic address:
    Objectives: The objective of this study was to investigate the epidemiological features of primary Sjögren's syndrome (pSS) in Korea at a national level, including the incidence, mortality, and causes of death.

    Methods: We used a national, population-based registry database called the Rare Intractable Disease Registration Program from the Health Insurance Review and Assessment Service to obtain pSS patient data for the period between 2010 and 2014. pSS was diagnosed by a physician based on uniform criteria. Read More

    Two cases of granulomatosis polyangiitis presenting with Strawberry gingivitis and a review of the literature.
    Semin Arthritis Rheum 2017 Jun 13. Epub 2017 Jun 13.
    Department of Clinical Immunology, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia.
    Hyperplastic gingivitis is a rare manifestation of granulomatosis with polyangiitis (GPA). This gingivitis has a very distinctive clinical appearance (so-called Strawberry gingivitis) and when seen is virtually pathognomic for GPA. Gingivitis often precedes other organ involvement therefore making awareness of this manifestation particularly important to aid early diagnosis and treatment. Read More

    Obesity and the risk of systemic lupus erythematosus among women in the Nurses' Health Studies.
    Semin Arthritis Rheum 2017 May 25. Epub 2017 May 25.
    Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115.
    Background: Obesity is increasingly prevalent and related to increased risk of several autoimmune diseases, likely via generation of inflammatory adipokines. Prior studies have not evaluated obesity in relation to systemic lupus erythematosus (SLE) risk. We prospectively evaluated whether obesity was associated with increased SLE risk among women in the U. Read More

    State of the art on nailfold capillaroscopy in dermatomyositis and polymyositis.
    Semin Arthritis Rheum 2017 Jun 28. Epub 2017 Jun 28.
    Division of Musculoskeletal and Rheumatic Disorders, Instituto Nacional de Rehabilitación, Mexico City, Mexico. Electronic address:
    Objectives: To provide an overview of the main nailfold capillaroscopy (NFC) changes described in dermatomyositis (DM) and polymyositis (PM) and to discuss the current evidence supporting its clinical relevance and applications in daily practice.

    Methods: All relevant literature in the field of NFC and DM and PM published in the last 30 years has been systematically reviewed. A systematic research was performed in the electronic databases PubMed and EMBASE. Read More

    Ultrasound entheseal abnormalities at the distal interphalangeal joints and clinical nail involvement in patients with psoriasis and psoriatic arthritis, supporting the nail-enthesitis theory.
    Semin Arthritis Rheum 2017 May 11. Epub 2017 May 11.
    Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, University Institute Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Fundacion Dr. Pedro M. Catoggio para el Progreso de la Reumatología, Buenos Aires, Argentina. Electronic address:
    Objective: It has been shown that nail involvement in psoriasis is associated with systemic enthesopathy. Our objective was to evaluate the association of nail involvement and enthesopathy at distal interphalangeal joint (DIP) level in psoriasis (PsO) and psoriatic arthritis (PsA) patients.

    Methods: Consecutive patients (54 PsO and 56 PsA) seen at the outpatients clinic in this cross-sectional study were included. Read More

    Choice of knee cartilage thickness change metric for different treatment goals in efficacy studies.
    Semin Arthritis Rheum 2017 May 30. Epub 2017 May 30.
    Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany.
    Introduction: In knee osteoarthritis, local increase and decrease in cartilage thickness has been observed over short time intervals. Hence, averaging cartilage change across large regions may not capture the complexity of structural alterations in disease progression. This study aims to examine the relative performance of different metrics of cartilage thickness change for different clinical studies scenarios. Read More

    How common is remission in juvenile idiopathic arthritis: A systematic review.
    Semin Arthritis Rheum 2017 May 20. Epub 2017 May 20.
    Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, Manchester, UK. Electronic address:
    Objectives: The ideal goal of treatment for juvenile idiopathic arthritis (JIA) is disease remission. However, many sets of remission criteria have been developed and no systematic review of remission in JIA exists. The current systematic review investigated (1) how remission has been defined across JIA clinical cohorts and (2) the frequency of remission overall and within disease categories. Read More

    High-resolution manometry compared with the University of California, Los Angeles Scleroderma Clinical Trials Consortium GIT 2.0 in Systemic Sclerosis.
    Semin Arthritis Rheum 2017 May 19. Epub 2017 May 19.
    Department of Medicine, Division of Rheumatology, University of California in Los Angeles(emeritus), Los Angeles, California; Department of Rheumatology, Division of Rheumatology, University of Washington, Seattle Washington; Division of Rheumatology and Experimental Medicine, University of Florence, Florence, Italy.
    Objectives: To study esophageal high resolution manometry (HRM) in systemic sclerosis (SSc) patients and the correlation of findings to The University of California, Los Angeles Scleroderma Clinical Trials Consortium gastrointestinal tract 2.0 (UCLA SCTC_GIT 2.0). Read More

    Development of an imaging mitigation strategy for patient enrolment in the tanezumab nerve growth factor inhibitor (NGF-ab) program with a focus on eligibility assessment.
    Semin Arthritis Rheum 2017 May 20. Epub 2017 May 20.
    Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA.
    Objective: Nerve growth factor antibodies (NGF-ab) have shown promising analgesic efficacy. Aim was to describe reader training efforts and present reliability data focusing on radiographic eligibility in the tanezumab program.

    Methods: A multi-step process was used for reader calibration and reliability testing. Read More

    Clinical and imaging mimickers of axial spondyloarthritis.
    Semin Arthritis Rheum 2017 May 20. Epub 2017 May 20.
    Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    The first step in the diagnosis of a patient with suspected axial spondyloarthritis is to differentiate the signs and symptoms of the disease from other disorders, potentially manifesting with similar clinical and imaging features. This review examines diffuse idiopathic skeletal hyperostosis, osteitis condensans ilii, and other developmental and metabolic disorders that may mimic axial spondyloarthritis, highlighting the diagnostic caveats and discussing shared and distinguishing aspects of these conditions in order to improve the clinician's ability to set them apart. Read More

    The role of platelets in autoimmunity, vasculopathy, and fibrosis: Implications for systemic sclerosis.
    Semin Arthritis Rheum 2017 May 23. Epub 2017 May 23.
    Division of Rheumatology, Department of Internal Medicine, University of Patras Medical School, Patras University Hospital, 26504 Rion, Patras, Greece. Electronic address:
    Introduction: Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, autoimmunity, and widespread dermal and visceral fibrosis. This article summarizes the current knowledge about the potential contribution of platelets in the disease process and the rationale of targeting platelets as an adjunct treatment for SSc.

    Methods: We performed an electronic search (Medline) using the keywords platelets, systemic sclerosis, autoimmunity, fibrosis, Raynaud, and pulmonary arterial hypertension. Read More

    Predictive and prognostic factors influencing outcomes of rituximab therapy in systemic lupus erythematosus (SLE): A systematic review.
    Semin Arthritis Rheum 2017 May 5. Epub 2017 May 5.
    NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; Arthritis Research UK Centre for Epidemiology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester, UK. Electronic address:
    Background: The clinical outcomes following rituximab (RTX) treatment in patients with systemic lupus erythematosus (SLE) is highly variable. We aimed to identify predictive and prognostic factors associated with RTX therapy outcomes in patients with SLE.

    Methods: Studies in adults and paediatric patients with SLE were included. Read More

    The 2010 ACR/EULAR criteria are not sufficiently accurate in the early identification of autoantibody-negative rheumatoid arthritis: Results from the Leiden-EAC and ESPOIR cohorts.
    Semin Arthritis Rheum 2017 Apr 29. Epub 2017 Apr 29.
    Department of Rheumatology, C1-R, Leiden University Medical Center, PO Box 9600, Leiden 2300RC, The Netherlands.
    Objectives: The 2010 ACR/EULAR criteria were derived to classify rheumatoid arthritis (RA) earlier in time. Previous studies indeed observed that the 2010 criteria were fulfilled earlier than the 1987 criteria. This study determined whether the 2010 criteria perform equally in early classification of autoantibody-positive and autoantibody-negative RA. Read More

    Association between acute gouty arthritis and meteorological factors: An ecological study using a systematic review and meta-analysis.
    Semin Arthritis Rheum 2017 May 20. Epub 2017 May 20.
    Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Wangsimni-ro 222-1, Seongdong-gu, Seoul, Republic of Korea 04763. Electronic address:
    Objectives: The aims of this study were as follows: (1) to analyze the literature systematically regarding the seasonal and monthly variation of the occurrence of episodes of acute gouty arthritis, and (2) to investigate the relationship between the occurrence of episodes of acute gouty arthritis and meteorological parameters.

    Methods: The present authors systematically reviewed databases for articles published before November 2015. Studies with quantitative data on episodes of acute gouty arthritis by months and/or seasons were included. Read More

    Transition to adult rheumatology care is necessary to maintain DMARD therapy in young people with juvenile idiopathic arthritis.
    Semin Arthritis Rheum 2017 May 12. Epub 2017 May 12.
    Department of Epidemiology, German Rheumatism Research Centre, Berlin, Germany; Charité University Medicine, Berlin, Germany.
    Objective: To evaluate the outpatient health service utilisation of young people (YP) with juvenile idiopathic arthritis (JIA) during transfer from paediatric to adult care in Germany.

    Methods: Based on claims data of a large German statutory health fund (BARMER GEK) we conducted a cohort study of 2008-2014. Insured YP with diagnosis of JIA (ICD: M08 or M09. Read More

    MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case-control study.
    Semin Arthritis Rheum 2017 Apr 27. Epub 2017 Apr 27.
    Department of Paediatrics, "G. d'Annunzio" University, Chieti-Pescara, Italy. Electronic address:
    Background: Mannose-binding lectins and human ficolins are pattern-recognition proteins involved in innate immunity. A role for MBL2 and FCN2 gene polymorphisms in the pathogenesis of recurrent severe streptococcal infections and rheumatic carditis has been suggested.

    Objectives: The aim of this study is to evaluate the presence of MBL2 and FCN2 gene polymorphisms (SNPs) in children with a history of rheumatic fever (RF) and to investigate their possible role in RF clinical presentation and disease course. Read More

    Serological evolution in women with positive antiphospholipid antibodies.
    Semin Arthritis Rheum 2017 May 10. Epub 2017 May 10.
    Rheumatology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, Facultad de Medicina, Universidad de Cantabria, Av Valdecilla s/n, 39011 Santander, Spain. Electronic address:
    Objectives: To explore the clinical and serological course of fertile women with positive antiphospholipid (aPL), and the factors and therapeutic implications associated with aPL negativization.

    Methods: Retrospective study including 105 women with a positive aPL serology between 1995 and 2013 attending the obstetric autoimmune pathology clinic of a tertiary facility. Patients were classified into the following 3 groups: patients with primary antiphospholipid syndrome (pAPS, 49), patients with a positive serology for aPL, not meeting clinical criteria (42), and patients with systemic lupus erythematosus and a positive aPL serology (14). Read More

    Switching tumor necrosis factor inhibitors in the treatment of axial spondyloarthritis.
    Semin Arthritis Rheum 2017 Apr 25. Epub 2017 Apr 25.
    Ronald Reagan UCLA Medical Center, Los Angeles, CA.
    Objective: To assess the impact of switching tumor necrosis factor (TNF)-alpha inhibitors on patients with axial spondyloarthritis (axSpA).

    Methods: PubMed literature searches were conducted using combinations of search terms including ankylosing spondylitis, spondyloarthropathy, spondyloarthritis, switch/switching, drug survival, and TNF/tumor necrosis factor to identify published articles with data on outcomes related to switching biologic therapies in patients with axSpA.

    Results: Of the 134 studies screened, 21 were identified as reporting data on switching TNF inhibitors in patients carrying a diagnosis of axSpA or ankylosing spondylitis. Read More

    Contemporary prevalence estimates for giant cell arteritis and polymyalgia rheumatica, 2015.
    Semin Arthritis Rheum 2017 Apr 7. Epub 2017 Apr 7.
    Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN; Division of Epidemiology, Department of Health Science Research, Mayo Clinic College of Medicine and Science, Rochester, MN. Electronic address:
    Objective: There are no estimates of the prevalence of giant cell arteritis (GCA) or polymyalgia rheumatica (PMR) in a US population in the current millennium. The purpose of this study was to estimate the 2015 prevalence of GCA and PMR in a US population-based setting.

    Methods: Cohorts of incident GCA in 1950-2009 and incident PMR in 1970-2014 were previously identified among residents of Olmsted County, Minnesota. Read More

    Clinical and sonographic biomarkers of structural damage progression in RA patients in clinical remission: A prospective study with 12 months follow-up.
    Semin Arthritis Rheum 2017 May 1. Epub 2017 May 1.
    Arthritis Unit, Rheumatology Department, Hospital Clínic, IDIBAPS, Villarroel, 170, 08036 Barcelona, Spain. Electronic address:
    Objective: To determine clinical and sonographic biomarkers predicting structural damage progression at 12 months of follow-up as measured by magnetic resonance imaging (MRI) in rheumatoid arthritis (RA) patients in clinical remission.

    Patients And Methods: We included patients with RA in clinical remission, defined as 28-joint disease activity score (DAS28)-erythrocyte sedimentation rate (ESR) <2.6 for >6 months. Read More

    Prevalence and correlates of hepatitis C virus-associated inflammatory arthritis in a population-based cohort.
    Semin Arthritis Rheum 2017 Apr 24. Epub 2017 Apr 24.
    Department of Laboratory Medicine, University of Washington, Seattle, WA; Rheumatology Division, Department of Medicine, University of Washington, Seattle, WA.
    Objectives: The objectives of this study were to determine the prevalence of hepatitis C virus-associated inflammatory arthritis, to describe its clinical and immunologic correlates, and to identify features that are characteristic of arthritis in chronic hepatitis C.

    Methods: Participants with chronic hepatitis C infection enrolled in a population-based cohort study in Alaska and who had not received anti-viral treatment for hepatitis C were recruited. In a cross-sectional study, we assessed joint symptoms and signs, performed autoantibody and cytokine testing, and abstracted medical records for features of hepatitis C and arthritis. Read More

    Global assessments of disease activity are age-dependent determinant factors of clinical remission in rheumatoid arthritis.
    Semin Arthritis Rheum 2017 Apr 28. Epub 2017 Apr 28.
    Division of Rheumatology, Department of Internal Medicine, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-8515, Japan. Electronic address:
    Objective: The aim of the study is to assess the factors associated with clinical remission of patients with rheumatoid arthritis (RA) in daily clinical practice.

    Methods: This analysis was based on the data of 304 RA patients in our center between May 2014 and March 2015. The following information was included: tender, swollen, and symptomatic joint counts, patient's and physician's global assessments, functional disability, laboratory and radiographic data, and RA treatments received. Read More

    Cardiovascular magnetic resonance in systemic sclerosis: "Pearls and pitfalls".
    Semin Arthritis Rheum 2017 Aug 31;47(1):79-85. Epub 2017 Mar 31.
    Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Department of Geriatric Medicine, AOUC, Florence, Italy.
    Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular dysfunction and excessive fibrosis, involving internal organs including the heart. The estimated prevalence of cardiac involvement in SSc is high and remains subclinical until the late stages. It is either primary, related to myocardial inflammation and fibrosis, or secondary, due to pulmonary arterial hypertension (SSc-PAH) or systemic hypertension, in those patients with renal involvement. Read More

    A cohort study reveals myocarditis to be a rare and life-threatening presentation of large vessel vasculitis.
    Semin Arthritis Rheum 2017 Apr 4. Epub 2017 Apr 4.
    Rheumatology Department, Imperial College Healthcare NHS Trust and Imperial College London, Hammersmith Hospital, London, UK.
    Background: The predominant forms of adult large vessel vasculitis (LVV) are giant cell arteritis (GCA) and Takayasu arteritis (TA). Cardiac involvement in LVV is a cause of morbidity and mortality, particularly in TA. Cardiac failure is most commonly secondary to uncontrolled arterial hypertension or myocardial ischaemia. Read More

    A systematic review of quality-of-life domains and items relevant to patients with spondyloarthritis.
    Semin Arthritis Rheum 2017 Apr 18. Epub 2017 Apr 18.
    Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore. Electronic address:
    Objectives: To summarize, from the literature, quality-of-life (QoL) domains and items relevant to patients with spondyloarthritis (SpA), and to determine if commonly used SpA patient-reported outcome (PRO) instruments include the identified domains.

    Methods: We used PRISMA statement for systematic review and searched Medline(®) , Embase(®), and PsycInfo(®) using relevant keywords. In addition, hand searches of references of the included articles were conducted. Read More

    Exercise and physical activity in systemic lupus erythematosus: A systematic review with meta-analyses.
    Semin Arthritis Rheum 2017 Apr 7. Epub 2017 Apr 7.
    Discipline of Physiotherapy, Trinity College, Dublin, Ireland.
    Systemic lupus erythematosus (SLE) associates with enhanced cardiovascular (CV) risk frequently unexplained by traditional risk factors. Physical inactivity, common in SLE, likely contributes to the burden of CV risk and may also be a factor in co-morbid chronic fatigue. This systematic review evaluates whether exercise has a deleterious effect on disease activity in SLE, and explores effects on CV function and risk factors, physical fitness and function and health-related measures. Read More

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