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    19122 results match your criteria Arthritis and rheumatism[Journal]

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    Dynamic patterns and predictors of hydroxychloroquine nonadherence among Medicaid beneficiaries with systemic lupus erythematosus.
    Semin Arthritis Rheum 2018 Jan 8. Epub 2018 Jan 8.
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
    Background: Hydroxychloroquine (HCQ) is the standard of care medication for most SLE patients, however nonadherence is common. We investigated longitudinal patterns and predictors of nonadherence to HCQ in a U.S. Read More

    Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative.
    Semin Arthritis Rheum 2018 Jan 31. Epub 2018 Jan 31.
    Division of Rheumatology, Tufts Medical Center, Boston, MA.
    Objective: Osteoarthritis (OA) is a disease with a substantial public health burden. Quantitative assessments of periarticular bone may be a biomarker capable of monitoring early disease progression. The purpose of this study was to evaluate whether measures of periarticular bone associate with longitudinal structural progression. Read More

    Enthesitis: A hallmark of psoriatic arthritis.
    Semin Arthritis Rheum 2018 Jan 6. Epub 2018 Jan 6.
    Intermountain Healthcare, Salt Lake City, UT.
    Objective: To describe the growing importance of enthesitis in patients with psoriatic arthritis (PsA) and discuss the advantages and disadvantages of clinical and imaging methods currently used to assess enthesitis.

    Methods: PubMed literature searches were conducted using the terms psoriatic arthritis, entheses, enthesitis, pathology, imaging, ultrasound, magnetic resonance imaging, clinical, and indices. Articles were deemed relevant if they provided insight into the pathology, monitoring, and/or diagnosis of enthesitis in PsA, or if they discussed clinical or imaging indices used to assess enthesitis. Read More

    Analysis of mortality in a cohort of 650 cases of bacteremic osteoarticular infections.
    Semin Arthritis Rheum 2018 Jan 31. Epub 2018 Jan 31.
    Department of Infectious Diseases, Hospital Universitari de Bellvitge, IDIBELL, Universidad de Barcelona, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
    Objectives: The mortality of patients with bacteremic osteoarticular infections (B-OAIs) is poorly understood. Whether certain types of OAIs carry higher mortality or interventions like surgical debridement can improve prognosis, are unclarified questions.

    Methods: Retrospective analysis of a prospective cohort of patients with B-OAIs treated at a teaching hospital in Barcelona (1985-2014), analyzing mortality (30-day case-fatality rate). Read More

    A systematic review of precipitating physical and psychological traumatic events in the development of fibromyalgia.
    Semin Arthritis Rheum 2018 Jan 10. Epub 2018 Jan 10.
    Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 5262100, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:
    The role of physical and psychological trauma precipitating fibromyalgia is often encountered by physicians, yet a proper systematical review of this association is lacking. Literature searches identified 51 studies which examined the association of fibromyalgia with a preceding traumatic event of physical or emotional nature. The overall quality of evidence of studies included, as assessed by the GRADE criteria, was low, however the majority of studies described a significant association between prior physically traumatic events and the onset of chronic widespread pain or fibromyalgia. Read More

    Systematic review, and meta-analysis of steroid-sparing effect, of biologic agents in randomized, placebo-controlled phase 3 trials for systemic lupus erythematosus.
    Semin Arthritis Rheum 2018 Jan 6. Epub 2018 Jan 6.
    Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia; Department of Medicine at St Vincent's Hospital, The University of Melbourne, Fitzroy, Victoria, Australia. Electronic address:
    Objectives: To systematically review, and conduct a meta-analysis of steroid-sparing effect in, phase 3 randomized, placebo-controlled trials of biologic therapies for systemic lupus erythematosus (SLE).

    Methods: Studies were identified by searching Medline (via Pubmed), EMBASE, CINAHL and SCOPUS databases, the Cochrane library, and Read More

    Abatacept in patients with rheumatoid arthritis and interstitial lung disease: A national multicenter study of 63 patients.
    Semin Arthritis Rheum 2018 Jan 6. Epub 2018 Jan 6.
    Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander Spain.
    Objective: Interstitial lung disease (ILD) is one of the most serious complications of rheumatoid arthritis (RA). In the present study, we aimed to assess the efficacy of abatacept (ABA) in patients with ILD associated to RA.

    Methods: National multicenter, non-controlled, open-label registry study of RA patients with ILD treated with ABA. Read More

    An association of smoking with serum urate and gout: A health paradox.
    Semin Arthritis Rheum 2017 Nov 22. Epub 2017 Nov 22.
    Department of Medicine, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand.
    Background: The potential effect of cigarette smoking on levels of serum urate and risk of gout has been considered by a large number of studies, either as the primary variable of interest or as a covariate.

    Methods: Here we systematically review the published evidence relating to the relationship of smoking with serum urate, hyperuricaemia, and gout.

    Results: Many studies have reported that smoking reduces serum urate, however, the evidence has not been conclusive with other studies pointing to the opposite or no effect. Read More

    Health-related quality of life in gout in primary care: Baseline findings from a cohort study.
    Semin Arthritis Rheum 2018 Jan 5. Epub 2018 Jan 5.
    Research Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK; Haywood Academic Rheumatology Centre, Haywood Hospital, Stoke-on-Trent, UK. Electronic address:
    Objectives: To examine gout-related, comorbid, and sociodemographic characteristics associated with generic and disease-specific health-related quality of life (HRQOL) in gout.

    Methods: Adults with gout from 20 general practices were mailed a questionnaire containing the Health Assessment Questionnaire-Disability Index (HAQ-DI), Short-Form-36 Physical Function subscale (PF-10), Gout Impact Scale (GIS), and questions about gout-specific, comorbid and sociodemographic characteristics. Variables associated with HRQOL were examined using multivariable linear regression models. Read More

    Prevalence and incidence of psoriatic arthritis: A systematic review and meta-analysis.
    Semin Arthritis Rheum 2018 Jan 6. Epub 2018 Jan 6.
    Laboratory of Healthcare Research and Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milan, Italy.
    Background: Psoriatic arthritis (PsA) is a specific form of inflammatory arthritis associated with psoriasis affecting in the same measure men and women but with a consistent geographic variability. Since the burden of PsA frequency has important implications in the definition of the healthcare policies, it is important to measure the frequency of disease in the general population.

    Objective: To quantify the global health burden of PsA summarizing the data provided by the population-based available studies investigating prevalence and incidence of the disease. Read More

    Pyridostigmine for the treatment of gastrointestinal symptoms in systemic sclerosis.
    Semin Arthritis Rheum 2018 Jan 5. Epub 2018 Jan 5.
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD.
    Background/purpose: Symptoms of gastrointestinal dysmotility are common among patients with systemic sclerosis (SSc), and the management of severe cases is often limited by a relative lack of effective interventions. The objective of this case series was to review our experience with pyridostigmine as a treatment for patients with SSc and symptomatic gastrointestinal disease.

    Methods: This study evaluated rates of symptom improvement, side effects, medication adherence, and dose ranges for SSc patients prescribed pyridostigmine for refractory gastrointestinal symptoms over a 10-year period at a quaternary referral center. Read More

    Extra-criteria manifestations of antiphospholipid syndrome: Risk assessment and management.
    Semin Arthritis Rheum 2018 Jan 5. Epub 2018 Jan 5.
    Hospital dasClinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
    Objectives: Extra-criteria manifestations of antiphospholipid syndrome (APS) might impact on prognosis and morbidity of the disease. In this study, we aimed to evaluate a population of patients with primary APS (PAPS) whether the extra-criteria manifestations were more frequently found in subjects with higher adjusted Global APS Score (aGAPSS) values when compared to patients with thrombotic and/or obstetric APS ("criteria" manifestations) only.

    Methods: Clinical records were analyzed to retrieve extra-criteria manifestation of APS, cardiovascular risk factors and antiphospholipid antibodies profile. Read More

    Assessing health-related quality of life in primary Sjögren's syndrome-The PSS-QoL.
    Semin Arthritis Rheum 2017 Nov 27. Epub 2017 Nov 27.
    Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, 8036 Graz, Austria; Rheumatology Service, South Tyrolean Health Trust, Hospital of Bruneck, Spitalstraße 11, 39031 Bruneck, Italy.
    Objectives: To develop a questionnaire for the assessment of health-related quality of life (HRQL) in primary Sjögren's syndrome (PSS), and to test its psychometric properties.

    Methods: Based on the concepts of a previous qualitative study, a questionnaire for the assessment of HRQL in PSS (PSS-QoL) was developed. Psychometric testing of PSS-QoL was performed after revising the first draft with feedback of patients (n = 6) and clinicians (n = 4). Read More

    Membrane attack complex (mac) deposition in lupus nephritis is associated with hypertension and poor clinical response to treatment.
    Semin Arthritis Rheum 2018 Jan 6. Epub 2018 Jan 6.
    Medicine, Division of Rheumatology, NYU Langone Health, 301 East 17th St, Suite 1410, New York, NY 10003.
    Objective: To study membrane attack complex in lupus nephritis as a potential biomarker for disease intensity and prognostic indicator for response to treatment.

    Methods: Immunohistochemistry was performed using unconjugated, murine anti-human complement C9 on kidney biopsies from 30 SLE patients who fulfilled 4 ACR or SLICC criteria. Clinical parameters were assessed at time of biopsy, 6 and 12 months. Read More

    Lessons learned from bone marrow failure in systemic lupus erythematosus: Case reports and review of the literature.
    Semin Arthritis Rheum 2017 Dec 8. Epub 2017 Dec 8.
    Division of Rheumatology, Northwell Health, Great Neck, NY.
    Objective: In the present review, four new cases of bone marrow failure are presented and the potential contribution of systemic lupus erythematosus (SLE) is discussed. Furthermore, a comprehensive literature review of cases of autoimmune myelofibrosis (AIMF), aplastic anemia (AA), and paroxysmal nocturnal hemoglobinuria (PNH) with concurrent SLE aims to allow their direct comparison. Based on a clearer characterization of reported cases and our own experience, diagnostic and therapeutic strategies of these disorders in SLE are proposed based on lessons learned from the present and previous cases. Read More

    Concurrence of rheumatoid arthritis and calcium pyrophosphate deposition disease: A case collection and review of the literature.
    Semin Arthritis Rheum 2017 Dec 2. Epub 2017 Dec 2.
    Division of Rheumatology, Department of Medicine, Medical College of Wisconsin, FOEB, 4th Floor, 9200 Wisconsin Ave, Milwaukee, WI 53226.
    Objective: Calcium pyrophosphate deposition disease (CPDD) is arthritis caused by calcium pyrophosphate (CPP) crystal deposition in joints. It is commonly associated with aging as well as a handful of metabolic syndromes. Recent epidemiologic studies suggest a positive association of CPDD and rheumatoid arthritis (RA). Read More

    Bronchiectasis is highly prevalent in anti-MPO ANCA-associated vasculitis and is associated with a distinct disease presentation.
    Semin Arthritis Rheum 2017 Dec 7. Epub 2017 Dec 7.
    Service de Médecine Interne, CHU de Nantes, Nantes, France; Centre de Recherche en Transplantation et Immunologie (UMR1064), INSERM, Université de Nantes, Nantes, France.
    Objectives: To assess the prevalence of bronchiectasis in a Western cohort with ANCA-positive granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) and its correlations with disease presentation and outcome.

    Methods: Retrospective study of ANCA-associated vasculitis (AAV) patients followed at Nantes University Hospital (2005-2015). Clinical, biological, and follow-up data were collected through chart review. Read More

    Evidence of reduced parasympathetic autonomic regulation in inflammatory joint disease: A meta-analyses study.
    Semin Arthritis Rheum 2017 Dec 5. Epub 2017 Dec 5.
    Department of Rheumatology, National Resource Centre for Rehabilitation in Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
    Background: Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are inflammatory joint disorders (IJD) with increased risk of cardiovascular disease (CVD). Autonomic dysfunction (AD) is a risk factor for CVD, and parasympathetic AD is linked to key features of IJD such as inflammation, physical inactivity and pain. Heart-rate variability (HRV) is a marker of cardiac AD. Read More

    Prevalence and risk factors for osteoporosis and fractures in axial spondyloarthritis: A systematic review and meta-analysis.
    Semin Arthritis Rheum 2017 Dec 7. Epub 2017 Dec 7.
    Instituto de Salud Musculoesquelética, Madrid, Spain.
    Objectives: To describe the prevalence of osteoporosis, the prevalence and incidence of fractures, and the frequency of risk factors for low bone mineral density (BMD) in axial spondyloarthritis (Ax-SpA).

    Methods: A systematic review and meta-analysis of observational studies was conducted. Medline, Embase, and Cochrane Library databases were searched with a sensitive strategy. Read More

    Guidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: Consensus of a Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).
    Semin Arthritis Rheum 2017 Dec 7. Epub 2017 Dec 7.
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK. Electronic address:
    Objectives: To gather expert opinion on the conduct of clinical trials that will facilitate regulatory review and approval of appropriate efficacious pharmacological treatments for hand osteoarthritis (OA), an area of high unmet clinical need.

    Methods: The European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO) organized a working group under the auspices of the International Osteoporosis Foundation (IOF) and the World Health Organization (WHO).

    Results: This consensus guideline is intended to provide a reference tool for practice, and should allow for better standardization of the conduct of clinical trials in hand OA. Read More

    Autoimmune arthritis in Ménière's disease: A systematic review of the literature.
    Semin Arthritis Rheum 2017 Nov 29. Epub 2017 Nov 29.
    Department of Otolaryngology-Head and Neck Surgery, Queen Elizabeth University Hospital, Glasgow, United Kingdom.
    Introduction: Successful management of patients with Ménière's disease (MD) involves understanding the pathophysiology of the disease and its comorbidities. The role of autoimmune diseases (AD) in MD remains unclear. The aim of this study was to further investigate the association between MD and AD. Read More

    Intra cranial granulomatous disease in common variable immunodeficiency: Case series and review of the literature.
    Semin Arthritis Rheum 2017 Oct 20. Epub 2017 Oct 20.
    Division of Rheumatology, Cleveland Clinic, Cleveland, OH.
    Background/purpose: Common variable immunodeficiency (CVID) is typically characterized by hypogammaglobulinemia and often but not always recurrent infections. Paradoxically, 8-22% of patients with CVID develop granulomatous disease. Granulomata have been described in many organs including the lungs, skin, liver, spleen, kidneys, eyes, lymph nodes, and intestines. Read More

    Chronic tophaceous gout as the first manifestation of gout in two cases and a review of the literature.
    Semin Arthritis Rheum 2017 Nov 27. Epub 2017 Nov 27.
    Rheumatic Diseases Unit, Ha'Emek Medical Center, Afula 18101, Israel; The Technicon Institute of Technology, Haifa, Israel.
    Objectives: Acute gout is a common arthritis that may eventually develop into chronic tophaceous gout (CTG). CTG usually is manifested by recurrent gout attacks. The diagnosis and treatment of CTG is challenging. Read More

    Hepatobiliary involvement in systemic sclerosis and the cutaneous subsets: Characteristics and survival of patients from the Spanish RESCLE Registry.
    Semin Arthritis Rheum 2017 Oct 6. Epub 2017 Oct 6.
    Department of Internal Medicine, Hospital Universitario Parc Taulí, Institut d'Investigació i Innovació Parc Taulí I3PT, Sabadell, Barcelona, Spain; Department of Medicine, Universidad Autónoma de Barcelona, Barcelona, Spain. Electronic address:
    Objective: To assess the prevalence and causes of hepatobiliary involvement (HBI) in systemic sclerosis (SSc), to investigate the clinical characteristics and prognosis of SSc patients with HBI (SSc-HBI) and without HBI (SSc-non-HBI), and to compare both groups according to the cutaneous SSc subsets.

    Methods: In all, 1572 SSc patients were collected in the RESCLE registry up to January 2015, and all hepatobiliary disturbances were recorded. We investigated the HBI-related characteristics and survival from the entire SSc cohort and according to the following cutaneous subsets: diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc), and SSc sine scleroderma (ssSSc). Read More

    Association of anti-cyclic citrullinated protein antibodies, erosions, and rheumatoid factor with disease activity and work productivity: A patient registry study.
    Semin Arthritis Rheum 2017 Oct 13. Epub 2017 Oct 13.
    Department of Medicine, Rheumatology, Immunology Brigham and Women's Hospital, and Harvard Medical School, PBB3, 75 Francis Street, Boston, MA 02115.
    Objectives: To evaluate associations between the presence of anti-cyclic citrullinated protein antibodies (anti-CCP) and rheumatoid factor (RF) and other outcomes, including joint erosions and both clinical and economic endpoints, in patients with rheumatoid arthritis (RA).

    Methods: Data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS), a prospective registry of adult RA patients with established or recent-onset RA, were analyzed. Logistic regression models were constructed to test associations between anti-CCP/RF seropositivity and erosive disease and the presence of anti-CCP/RF seropositivity plus erosive disease and (1) RA severity; (2) hospitalizations; (3) durable medical equipment (DME) use; and (4) worker productivity (e. Read More

    Body composition and clinical symptoms in patients with hip or knee osteoarthritis: Results from the KHOALA cohort.
    Semin Arthritis Rheum 2017 Oct 18. Epub 2017 Oct 18.
    CHRU Nancy, Rheumatology Department, F-54500, Nancy, France; Université de lorraine, EA 4360 Apemac, F-54500, Nancy, France. Electronic address:
    Objective: To analyze the associations between body composition, notably low lean mass, and clinical symptoms [pain, physical function, quality of life (QoL)] in patients with symptomatic hip and/or knee OA.

    Methods: Cross-sectional study using data from the 3-year follow-up visit of the Knee and Hip OsteoArthritis Long-term assessment (KHOALA) cohort. Skeletal muscle and fat mass were measured by dual X-ray absorptiometry (DXA). Read More

    Pregnancy outcomes in adult patients with dermatomyositis and polymyositis.
    Semin Arthritis Rheum 2017 Nov 20. Epub 2017 Nov 20.
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA. Electronic address:
    Objective: The idiopathic inflammatory myopathies dermatomyositis (DM) and polymyositis (PM) are autoimmune diseases that can affect females of childbearing potential. We assessed pregnancy outcomes in DM and PM patients compared with the general obstetric population.

    Methods: The Nationwide Inpatient Sample (NIS) (1993-2007) was used to identify delivery-associated hospitalizations in women with DM or PM (DM/PM, n = 853). Read More

    Growth patterns in early juvenile idiopathic arthritis: Results from the Childhood Arthritis Prospective Study (CAPS).
    Semin Arthritis Rheum 2017 Nov 7. Epub 2017 Nov 7.
    Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Division of Musculoskeletal & Dermatological Sciences. Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:
    Objectives: To investigate early vertical growth patterns and factors associated with poor growth in a modern inception cohort of UK children with juvenile idiopathic arthritis (JIA) using data from the Childhood Arthritis Prospective Study (CAPS).

    Methods: A study period of 3 years was chosen. Children included in this analysis had a physician diagnosis of JIA and had height measurements available at both baseline and at 3-years of follow-up. Read More

    Medication adherence among patients with gout: A systematic review and meta-analysis.
    Semin Arthritis Rheum 2017 Oct 7. Epub 2017 Oct 7.
    Department of Internal Medicine, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands.
    Objective: In the management of chronic gout, a large proportion of patients need long-term management with urate lowering therapy (ULT). This study reviews medication adherence to ULT and summarizes factors associated with adherence.

    Methods: We performed a systematic literature search for studies on adherence to ULT among gout patients in PubMed, Embase, CINAHL, and PsycINFO. Read More

    Ischemic complications in Takayasu's arteritis: A meta-analysis.
    Semin Arthritis Rheum 2017 Nov 10. Epub 2017 Nov 10.
    Department of Microbiology and Immunology, The University of Western Ontario, London, Ont., Canada. Electronic address:
    Objectives: Takayasu's arteritis (TAK) is a rare vasculitis affecting the large blood vessels with significant morbidity and mortality from ischemic complications. The objective of this meta-analysis is to determine the proportion of TAK patients with severe ischemic complications.

    Methods: We performed a literature search using MEDLINE, EMBASE, and the Cochrane library from database inception to March 2016. Read More

    Clinical, histological, immunological presentations and outcomes of bullous systemic lupus erythematosus: 10 New cases and a literature review of 118 cases.
    Semin Arthritis Rheum 2017 Nov 4. Epub 2017 Nov 4.
    AP-HP, Service de Médecine Interne 2, Centre National de Référence des Maladies Systémiques Rares, Lupus et Syndrome des Anticorps antiphospholipides, Institut e3m, Groupe Hospitalier Pitié-Salpêtrière, Paris 75013, France; Université Paris VI Pierre et Marie Curie, Sorbonnes Universités, Paris 75013, France.
    Background: Bullous systemic lupus erythematosus (BSLE) is a rare blistering condition associated with systemic lupus erythematosus (SLE).

    Patients And Methods: We conducted a multi-center retrospective study and literature review in order to describe the clinical, immunological, and histological presentations and outcomes of BSLE. The skin biopsies were centrally reviewed, and sera obtained during a flare of BSLE were analyzed for identification of circulating anti-basement membrane zone antibodies. Read More

    Rheumatologic symptoms in oncologic patients on PD-1 inhibitors.
    Semin Arthritis Rheum 2017 Oct 31. Epub 2017 Oct 31.
    Harvard Medical School, Boston, MA; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, 60 Fenwood Rd, Boston, MA.
    Objective: Immune checkpoint inhibitors are effective cancer therapies that have been associated with immune-related adverse events (irAEs). Recent reports of irAEs describe symptoms resembling classic rheumatologic syndromes, most notably associated with cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitor blockade. Though cases have been described, there are fewer reports of rheumatologic disease associated with programmed cell death protein-1 (PD-1) inhibitors. Read More

    Survivin improves the early recognition of rheumatoid arthritis among patients with arthralgia: A population-based study within two university cities of Sweden.
    Semin Arthritis Rheum 2017 Oct 31. Epub 2017 Oct 31.
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Gothenburg, Box 480, SE 405 30 Gothenburg, Sweden. Electronic address:
    Objectives: The aim of this study was to validate the use of survivin for preclinical recognition of rheumatoid arthritis (RA) among patients with unexplained arthralgia.

    Methods: Serum levels of survivin and the arthritis-specific autoantibodies RF and ACPA were measured in total of 5046 patients with musculoskeletal complains during 12 consecutive months in Gothenburg and in Umeå. Among them, 303 arthralgia patients were identified and prospectively followed. Read More

    Footwear interventions for foot pain, function, impairment and disability for people with foot and ankle arthritis: A literature review.
    Semin Arthritis Rheum 2017 Nov 3. Epub 2017 Nov 3.
    Health and Rehabilitation Research Institute, AUT University, Private Bag 92006, Auckland, New Zealand.
    Objective: To conduct a literature review on the effectiveness of footwear on foot pain, function, impairment and disability for people with foot and ankle arthritis.

    Methods: A search of the electronic databases Scopus, Medline, CINAHL, SportDiscus and the Cochrane Library was undertaken in September 2017. The key inclusion criteria were studies reporting on findings of footwear interventions for people with arthritis with foot pain, function, impairment and/or disability. Read More

    A randomized, double-blind, placebo-controlled trial of infliximab in refractory polymyositis and dermatomyositis.
    Semin Arthritis Rheum 2017 Oct 16. Epub 2017 Oct 16.
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health.
    Objective: To investigate in a pilot study the safety and efficacy of infliximab in patients with refractory dermatomyositis (DM) and polymyositis (PM).

    Methods: A randomized, double-blind, placebo-controlled trial including subjects with active DM or PM. Participants had stable doses of immunosuppressive medication and prednisone (≤0. Read More

    Patient-perceived health service needs in inflammatory arthritis: A systematic scoping review.
    Semin Arthritis Rheum 2017 Oct 31. Epub 2017 Oct 31.
    Department of Epidemiology and Preventative Medicine, School of Public Health and Preventive Medicine, Monash University, The Alfred Centre, Commercial Rd, Victoria 3004, Melbourne, Australia. Electronic address:
    Background: Care that is patient-centred is more likely to be sustainable and associated with improved health outcomes. This approach to care requires an understanding of patients' health service needs, yet few studies have directly investigated the perceived health service needs of people with inflammatory arthritis.

    Objectives: To systematically identify the existing literature relating to patient perceived health service needs for inflammatory arthritis. Read More

    Environmental triggers in systemic lupus erythematosus.
    Semin Arthritis Rheum 2017 Oct 5. Epub 2017 Oct 5.
    Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
    Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect almost any organ in the human body. Despite significant advancements in our understanding of SLE over the recent years, its exact mode of onset and disease progression remains elusive. Low concordance rates among monozygotic twins with SLE (as low as 24%), clustering of disease prevalence around polluted regions and an urban-rural difference in prevalence all highlight the importance of environmental influences in SLE. Read More

    Presence of comorbidities and prognosis of clinical symptoms in knee and/or hip osteoarthritis: A systematic review and meta-analysis.
    Semin Arthritis Rheum 2017 Oct 31. Epub 2017 Oct 31.
    Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Ghent University Hospital Campus, Building 3B3, Room 007, De Pintelaan 185, BE-9000, Ghent, Belgium; FWO (Pegasus)(2) EU Marie-Sklodowska Curie Fellow, EU Horizon 2020 Program, Brussels, Belgium. Electronic address:
    Objective: (i) To determine the association between the presence of comorbidities and severity of pain and physical dysfunction in people with knee and/or hip osteoarthritis; (ii) to explore associations between specific comorbidities (cardiac disease and/or hypertension, diabetes, depression, and back pain) and symptom severity.

    Methods: Studies were identified through systematic searches in four electronic databases and grey literature, and, subsequently, methodologically appraised. Eligible citations entailed cross-sectional or longitudinal studies as well as randomised controlled trials providing data of a direct association between comorbidity presence and the severity of self-reported and/or performance-based symptoms of pain and/or physical functioning, in people with knee and/or hip osteoarthritis. Read More

    The combination of IL-6 and its soluble receptor is associated with the response of rheumatoid arthritis patients to tocilizumab.
    Semin Arthritis Rheum 2017 Nov 17. Epub 2017 Nov 17.
    Department of Immunology, Institut de Recerca, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain. Electronic address:
    Background: IL-6 contributes significantly to the chronic inflammatory process of rheumatoid arthritis (RA). Tocilizumab, a humanized anti-human IL-6 receptor antibody that blocks the signaling originated by the IL-6/IL-6R complex, is an effective treatment. However, predictors of the response to tocilizumab are still required. Read More

    Factors associated with use of disease modifying agents for rheumatoid arthritis in the National Hospital and Ambulatory Medical Care Survey.
    Semin Arthritis Rheum 2017 Oct 18. Epub 2017 Oct 18.
    Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, 220 Arch Street, 12th Floor, Baltimore, MD 21201.
    Objective: We examined the treatment patterns among adults with rheumatoid arthritis (RA) and identified factors influencing access to traditional and biological disease modifying antirheumatic drugs (DMARDs).

    Methods: We analyzed visits recorded in the National Ambulatory Medical Care Survey from 2005 to 2014 with a RA diagnosis. The primary outcome was DMARD use (traditional and/or biological). Read More

    Sensorimotor performance and function in people with osteoarthritis of the hand: A case-control comparison.
    Semin Arthritis Rheum 2017 Sep 25. Epub 2017 Sep 25.
    Health and Rehabilitation Research Institute, Auckland University of Technology, 90 Akoranga Drive, Northcote, Auckland 0627, New Zealand; Department of Anaesthesiology and Perioperative Medicine, North Shore Hospital, Waitemata Pain Service, Waitemata DHB, Takapuna, Westlake, Auckland, New Zealand.
    Objectives: To determine whether hand left/right judgements, tactile acuity, and body perception are impaired in people with hand OA. To examine the relationships between left right judgements, tactile acuity and hand pain. To explore the relationships between sensorimotor measures (left/right judgements and tactile acuity) and measures of hand function in people with hand OA. Read More

    Carotid and femoral atherosclerosis in antiphospholipid syndrome: Equivalent risk with diabetes mellitus in a case-control study.
    Semin Arthritis Rheum 2017 Oct 23. Epub 2017 Oct 23.
    Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:
    Background: Antiphospholipid syndrome (APS) may carry a worse prognosis for vascular complications when co-existing with subclinical atherosclerosis; however, the association between the two conditions remains ambiguous.

    Methods: We evaluated ultrasonographic markers of subclinical atherosclerosis in carotid and femoral arteries of 86 patients with thrombotic APS [43 primary APS (PAPS), 43 systemic lupus erythematosus-associated APS (SLE/APS)], 86 patients with diabetes mellitus (DM) and 86 healthy controls, individually matched for age and gender, and investigated their associations with traditional and disease-related factors in APS.

    Results: Carotid plaques were found in 28% of PAPS, 23% of SLE/APS, and 30% of DM patients versus 9% of controls (p = 0. Read More

    Risk factors and clinical characteristics of deep knee infection in patients with intra-articular injections: A matched retrospective cohort analysis.
    Semin Arthritis Rheum 2017 Oct 20. Epub 2017 Oct 20.
    Department of Orthopaedics, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address:
    Background: Deep knee infection (DKI), consisting of sepsis arthritis (SA) and chronic low-grade infection (CLGI), is a rare but catastrophic adverse event that can result from intra-articular (IA) injections. The purpose of this study was to assess the risk factors for DKI and describe the clinical characteristics of DKI in patients who received IA injections.

    Methods: Fifty patients with IA injection-induced DKI who underwent surgical treatment between January 2010 and May 2016 served as cases and were matched with non-infected controls who received IA injections in a proportion of 1:5 based on age, gender, and date of admission. Read More

    Protracted febrile myalgia syndrome treated with pulse of corticosteroids.
    Semin Arthritis Rheum 2017 Oct 12. Epub 2017 Oct 12.
    Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. Electronic address:
    Objective: This study describes our 5-year experience treating protracted febrile myalgia syndrome (PFMS) with pulsed doses of corticosteroids.

    Methods: Eight patients with PFMS who received pulse corticosteroid therapy were identified from the electronic database of a tertiary pediatric medical center (2011-2016). Their clinical and laboratory data were collected. Read More

    Vitamin D and antiphospholipid syndrome: A retrospective cohort study and meta-analysis.
    Semin Arthritis Rheum 2017 Oct 12. Epub 2017 Oct 12.
    Rheumatology Department, Facultad de Medicina, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Av Valdecilla s/n, 39008 Santander, Spain. Electronic address:
    Objectives: (a) To determine serum 25-OH vitamin D (vitD) levels in primary antiphospholipid syndrome (APS) and to compare them with patients with positive antiphospholipid serology who do not meet clinical criteria for APS, and with healthy controls. (b) To analyze the association of vitD levels with both the clinical manifestations and the immunological profile of patients with primary APS. (c) To perform a meta-analysis evaluating potential differences in serum vitD levels between APS and controls as well as the frequency of vitD deficiency in APS patients. Read More

    2013 ACR/EULAR systemic sclerosis classification criteria in patients with associated pulmonary arterial hypertension.
    Semin Arthritis Rheum 2017 Oct 13. Epub 2017 Oct 13.
    Servicio de Reumatología, Hospital Universitario12 de Octubre, Universidad Complutense de Madrid, Avda de Córdoba s/n, Madrid 28041, Spain. Electronic address:
    Objective: To analyze the performance of the 1980 ACR and new 2013 ACR/EULAR criteria for systemic sclerosis (SSc) in cutaneous SSc (lcSSc) patients, especially those affected by lcSSc and pulmonary arterial hypertension (PAH).

    Methods: All patients with a clinical lcSSc diagnosis from a prospective observational SSc cohort were included. Sociodemographic and disease-related variables were collected, and PAH confirmed by right heart catheterization (RHC). Read More

    Methods for segmentation of rheumatoid arthritis bone erosions in high-resolution peripheral quantitative computed tomography (HR-pQCT).
    Semin Arthritis Rheum 2017 Sep 23. Epub 2017 Sep 23.
    Institute of Medical Physics (IMP), Friedrich-Alexander-University Erlangen-Nüremberg (FAU), Henkestrasse 91, Erlangen 91052, Germany. Electronic address:
    Objective: The comparison between different techniques to quantify the 3-dimensional size of inflammatory bone erosions in rheumatoid arthritis(RA) patients.

    Methods: Anti-cyclic citrullinated peptide antibody(ACPA) positive RA patients received high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the metacarpophalangeal joints (MCP). Erosions were measured by three different segmentation techniques: (1) manual method with calculation by half-ellipsoid formula, (2) semi-automated modified Evaluation Script for Erosions (mESE), and (3) semi-automated Medical Image Analysis Framework (MIAF) software. Read More

    Blau syndrome with good Reponses to Tocilizumab: A case report and focused literature review.
    Semin Arthritis Rheum 2017 Sep 25. Epub 2017 Sep 25.
    Department of Pharmacology, the First Affiliated Hospital of Zhengzhou University, Higher Education Institute of Open Key Clinical Laboratory of He-nan Province, Zhengzhou Henan 450052, China.
    Objectives: Blau syndrome (BS), a rare auto-inflammatory granulomatous disease, is a progressive disorder. Usually the maintenance dose of glucocorticoid may not be tapered below 15 mg per day while immunosuppressives is used. There has been some experience with biologic agents in refractory BS patients. Read More

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