19,267 results match your criteria Arthritis and rheumatism[Journal]


Damage indices in rheumatic diseases: A systematic review of the literature.

Semin Arthritis Rheum 2019 Jan 17. Epub 2019 Jan 17.

The University of Melbourne, St Vincent's Hospital, Melbourne, Australia; St Vincent's Hospital, Melbourne, Australia. Electronic address:

Objective: To review the current literature, and evaluate the psychometric properties of disease damage indices in rheumatic diseases.

Methods: A search of Medline, EMBASE, and Cochrane Library databases was performed to June 2018 to identify damage indices in all systemic rheumatic diseases. Articles were included in a systematic review if indices were composite (multi-organ) in nature and if adequate detail on methodology was described. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.007DOI Listing
January 2019
1 Read

Cost-effectiveness of sequential treatment with abaloparatide vs. teriparatide for United States women at increased risk of fracture.

Semin Arthritis Rheum 2019 Jan 10. Epub 2019 Jan 10.

Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium; Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.

Objectives: There is emerging evidence supporting sequential therapy with an osteoanabolic followed by an antiresorptive in patients at high-risk of fragility fractures. This study assessed the cost-effectiveness of sequential treatment with abaloparatide (ABL) followed by alendronate (ALN) [(ABL/ALN)] compared with teriparatide (TPTD) followed by ALN (TPTD/ALN).

Methods: A previously validated Markov microsimulation model was adapted to estimate the cost-effectiveness of sequential ABL/ALN compared with sequential TPTD/ALN and no treatment with a lifetime horizon from the US payer perspective. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.006DOI Listing
January 2019
1 Read

Type 2 diabetes mellitus and osteoarthritis.

Semin Arthritis Rheum 2019 Jan 11. Epub 2019 Jan 11.

Division of Diabetes, Nutrition and Metabolic Disorders and Clinical Pharmacology Unit, Department of Medicine, University of Liège, CHU Liège, Sart Tilman B35, B-4000 Liège, Belgium.

Objectives: Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases that frequently co-exist, along with overweight/obesity. While the mechanical impact of excess body weight on joints may explain lower limb OA, we sought to explore whether T2DM is linked to OA outside of excess weight and whether T2DM may play a role in OA pathophysiology. The consequence of T2DM on OA outcomes is a question of research interest. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183058
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http://dx.doi.org/10.1016/j.semarthrit.2019.01.005DOI Listing
January 2019
2 Reads

Prevalence and discrimination of OMERACT-defined elementary ultrasound lesions of gout in people with asymptomatic hyperuricaemia: A systematic review and meta-analysis.

Semin Arthritis Rheum 2019 Jan 11. Epub 2019 Jan 11.

Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Objectives: Ultrasound lesions of gout have been described in people with asymptomatic hyperuricemia. However, the anatomical sites and ultrasound lesions most frequently involved in asymptomatic hyperuricemia have not yet been established. This systematic review and meta-analysis aimed to determine the prevalence of the Outcome Measures in Rheumatology (OMERACT) elementary ultrasound lesions of gout (double contour, aggregates, tophus, erosion) at various sites in people with asymptomatic hyperuricemia and to determine which sites and lesions discriminate from people with normouricemia. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.004DOI Listing
January 2019
1 Read

The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life.

Semin Arthritis Rheum 2018 Dec 28. Epub 2018 Dec 28.

Department of Rheumatology, Guy's and St Thomas' NHS Trust, 4th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, UK; Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, 1st Floor, New Hunt's House, Guy's Campus, King's College London, Great Maze Pond, London, UK.

Objective: Treat-to-target in rheumatoid arthritis (RA) recommends targeting remission, with low disease activity (LDA) being an alternative goal. When deciding to target remission or LDA, important considerations are the likelihood of attaining them, and their impacts on function and health-related quality of life (HRQoL). We have addressed this by studying: (a) the frequency of remission and LDA/remission; (b) DAS28-ESR trends after remission; (c) ability of remission vs. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.12.006DOI Listing
December 2018
1 Read

Identifying lupus patients in electronic health records: Development and validation of machine learning algorithms and application of rule-based algorithms.

Semin Arthritis Rheum 2019 Jan 4. Epub 2019 Jan 4.

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, United States.

Objective: To utilize electronic health records (EHRs) to study SLE, algorithms are needed to accurately identify these patients. We used machine learning to generate data-driven SLE EHR algorithms and assessed performance of existing rule-based algorithms.

Methods: We randomly selected subjects with ≥ 1 SLE ICD-9/10 codes from our EHR and identified gold standard definite and probable SLE cases by chart review, based on 1997 ACR or 2012 SLICC Classification Criteria. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.002DOI Listing
January 2019
1 Read

Commentary on the article: Hughes M & Pauling JD. Exploring the patient experience of digital ulcers in systemic sclerosis. Semin Arthritis Rheum. 2018 Aug 11. pii: S0049-0172(18)30354-8. doi: 10.1016/j.semarthrit.2018.08.001. [Epub ahead of print] Review.

Semin Arthritis Rheum 2018 Dec 29. Epub 2018 Dec 29.

Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1016/j.semarthrit.2018.12.005DOI Listing
December 2018
4 Reads

Ocular involvement in systemic sclerosis: A systematic literature review, it's not all scleroderma that meets the eye.

Semin Arthritis Rheum 2018 Dec 28. Epub 2018 Dec 28.

Department of Internal Medicine, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium; Department of Rheumatology, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Corneel Heymanslaan 10, 9000 Ghent, Belgium. Electronic address:

Objectives: Systemic sclerosis (SSc) is a rare and complex autoimmune disorder characterized by microvascular damage and progressive fibrosis which affects the skin and multiple other organs. Much of the published data concerning SSc and the eye consists of single case reports or small case studies. This systematic review aims to provide an overview of the current level of evidence for SSc-related ocular changes. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.12.007DOI Listing
December 2018
2 Reads

Predicting flares in patients with stable systemic lupus erythematosus.

Semin Arthritis Rheum 2019 Jan 5. Epub 2019 Jan 5.

Division of Rheumatology, Department of Medicine, National University Hospital of Singapore, Level 10, NUHS Tower Block, 1E Kent Ridge Road, 119228, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Objectives: Data on flares in Asian patients with systemic lupus erythematosus (SLE) are scarce. Here, we aim to identify the baseline predictors of flares in a cohort of Southeast Asian patients with SLE.

Methods: Consecutive adult patients with prevalent SLE according to the 1997 ACR or 2012 SLICC criteria were enrolled and followed three-monthly. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.001DOI Listing
January 2019
6 Reads

A better look at rheumatoid arthritis: Using imaging to improve patient outcomes.

Semin Arthritis Rheum 2018 Dec 21. Epub 2018 Dec 21.

Associate Professor of Medicine, Department of Medicine, Allergy/Immunology & Rheumatology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183077
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http://dx.doi.org/10.1016/j.semarthrit.2018.12.004DOI Listing
December 2018
7 Reads

Tocilizumab in giant cell arteritis. Observational, open-label multicenter study of 134 patients in clinical practice.

Semin Arthritis Rheum 2019 Jan 5. Epub 2019 Jan 5.

Departments of Rheumatology, Internal Medicine and Pathology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Spain. Electronic address:

Objective: Tocilizumab (TCZ) has shown efficacy in clinical trials on giant cell arteritis (GCA). Real-world data are scarce. Our objective was to assess efficacy and safety of TCZ in unselected patients with GCA in clinical practice Methods: Observational, open-label multicenter study from 40 national referral centers of GCA patients treated with TCZ due to inefficacy or adverse events of previous therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183057
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http://dx.doi.org/10.1016/j.semarthrit.2019.01.003DOI Listing
January 2019
4 Reads

Safety of combination therapy with two bDMARDs in patients with rheumatoid arthritis: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Dec 18. Epub 2018 Dec 18.

Rheumatology Department, Maison Blanche Hospital, Reims University Hospitals, 45 Rue Cognacq-Jay, Reims 51092, France; Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, 51095 Reims, France. Electronic address:

Objectives: We performed a systematic review and meta-analysis of the current literature to assess the safety of combining two biologic disease-modifying antirheumatic drugs (bDMARDs) in the treatment of rheumatoid arthritis (RA).

Methods: We systematically searched for controlled studies evaluating safety in patients with RA treated with two bDMARDs independently of dose-regimen. Databases used were MEDLINE (via Pubmed), EMBase, Cochrane Library, Scopus, ClinicalTrials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183065
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http://dx.doi.org/10.1016/j.semarthrit.2018.12.003DOI Listing
December 2018
6 Reads

The efficacy of dietary intervention on gastrointestinal involvement in systemic sclerosis: A systematic literature review.

Semin Arthritis Rheum 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK; Royal National Hospital for Rheumatic Diseases (part of Royal United Hospitals Bath NHS Foundation Trust), Upper Borough Walls, BA1, 1RL Bath, UK. Electronic address:

Background: Gastrointestinal involvement in systemic sclerosis is common and a major cause of disease-related morbidity. Patients increasingly enquire about dietary modifications that may help with gastrointestinal symptoms. Many clinical practice reviews and treatment guidelines make specific reference to dietary modifications in the management of gastrointestinal involvement in systemic sclerosis. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.12.001DOI Listing
December 2018
2 Reads

Sample size calculations for detecting disease-modifying osteoarthritis drug effects on the incidence of end-stage knee osteoarthritis in clinical trials: Data from the Osteoarthritis Initiative.

Semin Arthritis Rheum 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box #406, Boston, MA 02111, USA.

Objective: We previously published data representing calculations for sample sizes assuming that the reduction of the incidence of knee joint replacement (KJR) would be an endpoint to prove efficacy of a disease-modifying drug in osteoarthritis (DMOAD). The sample sizes required for such hypothetical studies appeared to be high, rendering those studies unrealistic in the clinical research setting for practical reasons. The purpose of this work is to calculate sample sizes for hypothetical trials for DMOAD efficacy using a proxy for reaching end-stage knee osteoarthritis (esKOA) as an endpoint. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183044
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http://dx.doi.org/10.1016/j.semarthrit.2018.12.002DOI Listing
December 2018
9 Reads

Characterization of indigenous community engagement in arthritis studies conducted in Canada, United States of America, Australia and New Zealand.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

Departments of Medicine and Community Health Sciences, University of Calgary and Rheumatologist, Alberta Health Services, 3330 Hospital Drive NW, T2N 4N1, Calgary, Alberta, Canada. Electronic address:

Background: Research adhering to community engagement processes leads to improved outcomes. The level of Indigenous communities' engagement in rheumatology research is unknown.

Objective: To characterize the frequency and level of community engagement reporting in arthritis studies conducted in Australia (AUS), Canada (CAN), New Zealand (NZ) and the United States of America (USA). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.009DOI Listing
December 2018
1 Read

Secondary thrombotic microangiopathy in systemic lupus erythematosus and antiphospholipid syndrome, the role of complement and use of eculizumab: Case series and review of literature.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 865 Northern Boulevard, Suite 302, Great Neck, NY 11021, USA.

Introduction: Thrombotic microangiopathy (TMA) is a life-threatening, albeit infrequent, complication of systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS). Recommendations for the treatment of SLE- and APS-related secondary TMA are currently based solely on case reports and expert opinion. Unfortunately, interventions may not yield timely results or effectively halt the progression of TMA. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.005DOI Listing
December 2018
2 Reads

Rheumatologic symptoms and checkpoint inhibitor - Stop pain or stop cancer?

Semin Arthritis Rheum 2018 Dec 5. Epub 2018 Dec 5.

Hospital Santo Antonio, Salvador, Bahia, Brazil; Universidade Salvador (UNIFACS), Salvador, Bahia, Brazil.

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.003DOI Listing
December 2018
1 Read

Update of the evidence based, interdisciplinary guideline for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

The Society for Paediatric Rheumatology (GKJR), Germany.

Background: Uveitis in juvenile idiopathic arthritis (JIAU) is frequently associated with the development of complications and visual loss. Topical corticosteroids are the first line therapy, and disease modifying anti-rheumatic drugs (DMARDs) are commonly used. However, treatment has not been standardized. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.004DOI Listing
December 2018
1 Read

Recapture and improved outcome of pegloticase response with methotrexate-A report of two cases and review of the literature.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

Osteoporosis and Arthritis Care, Henderson, NV, United States.

Introduction: Pegloticase is a PEGylated uric acid specific enzyme indicated for the treatment of refractory gout. Anti-pegloticase antibodies contribute to high discontinuation rates, increased risk of infusion reactions, and early loss of drug efficacy.

Objective: To describe the use of methotrexate to recapture function of pegloticase after development of anti-drug antibodies while treating gout. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.006DOI Listing
December 2018
2 Reads

Pulmonary arterial hypertension in adult-onset Still's disease: A case series and systematic review of the literature.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

Departments of Rheumatology, Hospital Son Llàtzer, Palma de Mallorca, Spain.

Objective: To investigate the prevalence, clinical characteristics and prognosis of pulmonary arterial hypertension (PAH) in adult onset Still's disease (AOSD).

Methods: We retrospectively reviewed all patients with AOSD diagnosed during a 33-year period in 2 referral tertiary care hospitals, selecting for analysis those who presented PAH confirmed as by right heart catheterization. A systematic review of the literature (PubMed 1990 to July 2018) was also performed, in order to determine the prognosis and the most appropriate treatment strategy for this complication. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.007DOI Listing
December 2018
2 Reads

Inpatient prevalence, burden and comorbidity of Takayasu's arteritis: Nationwide inpatient sample 2013-2014.

Semin Arthritis Rheum 2018 Dec 3. Epub 2018 Dec 3.

Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Jacksonville, FL, USA.

Objectives: To investigate the inpatient prevalence, characteristics and comorbidities of patients admitted with Takayasu's arteritis (TAK) in the United States (US).

Methods: Patients with TAK were identified within the Nationwide Inpatient Sample (NIS) database of the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on patient characteristics, comorbidities, resource utilization and expenditures was collected. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.008DOI Listing
December 2018
2 Reads
3.925 Impact Factor

Positron emission tomography costs less to patients than conventional screening for malignancy in dermatomyositis.

Semin Arthritis Rheum 2018 Nov 2. Epub 2018 Nov 2.

Penn State Hershey Medical Center, Department of Dermatology, 500 University Drive, Hershey, PA, USA. Electronic address:

Background: Dermatomyositis (DM) is associated with malignancy and interstitial lung disease. Many malignancies associated with DM occur in organs not routinely screened by national guidelines; thus, best screening practices are still debated. Positron emission tomography (PET) has been suggested as a single study alternative to more complex screening panels and may also be valuable in detecting interstitial lung disease progression. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.10.021DOI Listing
November 2018
1 Read

Corrigendum to "Psoriatic arthritis disease activity during pregnancy and the first-year postpartum" [Semin. Arthritis Rheum. 46 (6) (2017) 740-745].

Semin Arthritis Rheum 2018 Nov 23. Epub 2018 Nov 23.

Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Psoriatic Arthritis Program, Center for Prognostic Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.001DOI Listing
November 2018
6 Reads

The role of C-reactive protein as a predictor of treatment response in patients with ankylosing spondylitis.

Semin Arthritis Rheum 2018 Nov 2. Epub 2018 Nov 2.

Pfizer Innovative Health, Global Medical Affairs Pfizer Inc, Collegeville, PA, United States.

Objectives: To determine whether C-reactive protein (CRP) level is predictive of response to tumor necrosis factor-α blocker treatment in patients with ankylosing spondylitis (AS) and whether there is an optimal CRP range for treatment initiation.

Methods: In this post hoc analysis, data on etanercept-treated patients with AS were pooled from four randomized trials. Week 12 responses (ASAS20, ASAS50, ASDAS-CRP < 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183023
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.019DOI Listing
November 2018
17 Reads

Contemporary epidemiology of systemic sclerosis: A population-based cohort study in the United Kingdom.

Semin Arthritis Rheum 2018 Nov 10. Epub 2018 Nov 10.

Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Almirante 28, Madrid 28004, Spain; Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain.

Objective: To estimate the contemporary epidemiology of systemic sclerosis (SSc) in the UK and to explore the validity of using The Health Improvement Network (THIN) primary care database to study SSc.

Methods: 4,520,299 individuals (2000-2012) aged 1-99 years were followed to identify potential incident cases of SSc; potential prevalent cases were identified at start of follow-up. Patient profiles, including free-text comments, were manually reviewed to verify cases of SSc, and case validation was undertaken for a sample (n = 100) using questionnaires to primary care physicians. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.002DOI Listing
November 2018
7 Reads

Applicability of trials in rheumatoid arthritis and osteoarthritis: A systematic review and meta-analysis of trial populations showing adequate proportion of women, but underrepresentation of elderly people.

Semin Arthritis Rheum 2018 Nov 2. Epub 2018 Nov 2.

Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Objectives: To evaluate whether elderly people and women are adequately represented in randomized controlled trials (RCT) in rheumatoid arthritis (RA) and osteoarthritis (OA).

Methods: Four systematic searches in MEDLINE yielded RCT in RA and OA on any intervention published in 2016 and 2017 and population-based studies (PBS) in RA and OA published between 2013 and 2017. Random effects meta-analyses estimated the pooled proportion of elderly people (defined as being ≥ 65 years old), the mean age, its standard deviation (SD), and the proportion of women stratified by disease (RA and OA) and study type (RCT and PBS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183048
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.017DOI Listing
November 2018
10 Reads

Palliative and end-of-life care in rheumatology: High symptom prevalence and unmet needs.

Semin Arthritis Rheum 2018 Nov 2. Epub 2018 Nov 2.

Division of Rheumatology, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, NUHS, Level 10, NUHS Tower Block, 1E Kent Ridge Road, 119228 Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Objectives: To determine the extent of end-of-life suffering and predictors of high symptom prevalence in the last one year of life in patients with systemic rheumatic diseases (SRDs) and the extent of supportive care received.

Methods: We identified adult patients with SRDs who died between 1 April 2006 and 1 April 2016. We collected data within 1 year before their death, on the following: (i) cumulative symptom prevalence, (ii) rates of Advance Care Planning (ACP), Do-Not-Resuscitate (DNR) orders and referral to a palliative physician. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183042
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.020DOI Listing
November 2018
9 Reads

Antiphospholipid antibodies and renal transplant: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Oct 19. Epub 2018 Oct 19.

Immune Response and Vascular Disease Unit, CEDOC, NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Rua Câmara Pestana 6, 1150-082 Lisboa, Portugal.

Objective: To evaluate the effect of antiphospholipid antibodies (aPL) on renal allograft outcome after kidney transplantation.

Methods: A systematic search of EMBASE and PubMed databases from inception to July 2018 was run according to PRISMA guidelines; Peto's odds ratio (OR) for rare events was used for the meta-analysis.

Results: Our inclusion/exclusion criteria were met by 22 cohort studies having different outcomes: allograft thrombosis (n = 9) and thromboprophylaxis (n = 3), allograft loss from any cause (n = 9), allograft malfunction (n = 3), duration (n = 2), glomerular filtration rate at 1 year (n = 3) and allograft rejection (n = 5). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183059
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.016DOI Listing
October 2018
12 Reads

Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs.

Semin Arthritis Rheum 2018 Nov 3. Epub 2018 Nov 3.

Division of Rheumatology, University of California San Francisco, United States.

Introduction/objectives: Pneumocystis jirovecii pneumonia (PJP) is a rare but potentially fatal opportunistic infection; however, consensus varies around which conditions or medications confer a level of risk sufficient to justify antibiotic prophylaxis for PJP. We used electronic health record (EHR) data to assess the current patterns of PJP prophylaxis, PJP outcomes, and prophylaxis-related adverse events among patients with rheumatic diseases who were receiving high-risk immunosuppressant drugs.

Methods: Data derive from the EHR of a large health system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183026
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.018DOI Listing
November 2018
16 Reads

Anti-tumor necrosis factor agents in sarcoidosis: A systematic review of efficacy and safety.

Semin Arthritis Rheum 2018 Oct 16. Epub 2018 Oct 16.

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address:

Background: Though anti-tumor necrosis factor agents (anti-TNFs) have been recommended as third-line therapy for sarcoidosis, an up-to-date systematic synthesis of their efficacy and safety is lacking.

Objectives: To systematically review the literature to characterize the efficacy and safety of anti-TNFs in sarcoidosis.

Settings: All countries and treatment settings were included. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.10.005DOI Listing
October 2018
3 Reads
3.925 Impact Factor

A prospective study of obesity and risk of systemic lupus erythematosus (SLE) among Black women.

Semin Arthritis Rheum 2018 Oct 11. Epub 2018 Oct 11.

Slone Epidemiology Center at Boston University, 72 East Concord St, Boston, MA 02118, United States.

Background: Obesity may influence systemic lupus erythematous (SLE) pathogenesis via stimulation of systemic inflammation, but the relationship between obesity and SLE risk is unclear. Past studies have predominantly assessed White women, while Black women have higher prevalence of both obesity and SLE.

Methods: We prospectively assessed the relationship between Body Mass Index (BMI, kg/m) and incident SLE within the Black Women's Health Study (median age 38 at entry in 1995). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183042
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.004DOI Listing
October 2018
9 Reads

Aortic dilatation in patients with large vessel vasculitis: A longitudinal case control study using PET/CT.

Semin Arthritis Rheum 2018 Oct 12. Epub 2018 Oct 12.

Rheumatology Unit, Azienda Unità Sanitaria Locale Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Objective: To evaluate aortic diameter and predictors of aortic dilatation using FDG-PET/CT in a longitudinally followed cohort of patients with large vessel vasculitis (LVV) compared with controls.

Methods: All consecutive patients with LVV who underwent at least 2 PET/CT scans between January 2008 and May 2015 were included. The first and last PET/CT study was evaluated by a radiologist and a nuclear medicine physician. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183045
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.003DOI Listing
October 2018
19 Reads

Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritis: A European retrospective multicohort analysis.

Semin Arthritis Rheum 2018 Oct 12. Epub 2018 Oct 12.

INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University, Paris-Saclay University, Le Kremlin-Bicêtre, France; Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin Bicêtre Hospital, Le Kremlin-Bicêtre, France. Electronic address:

Objectives: To evaluate the incidence of anti-drug antibody (ADA) occurrences and ADA-related risk factors under adalimumab and infliximab treatment in rheumatoid arthritis (RA) patients.

Methods: The study combined retrospective cohorts from the ABIRISK project totaling 366 RA patients treated with adalimumab (n = 240) or infliximab (n = 126), 92.4% of them anti-TNF naive (n = 328/355) and 96. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183017
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.006DOI Listing
October 2018
39 Reads

Spinal involvement with calcium pyrophosphate deposition disease in an academic rheumatology center: A series of 37 patients.

Semin Arthritis Rheum 2018 Oct 14. Epub 2018 Oct 14.

Université Paris Diderot France, France; Department of Rheumatology, Hôpital Lariboisière, Assistance Publique des Hôpitaux de Paris, 75010 Paris, France; INSERM U1132, Hôpital Lariboisière, Université Paris Diderot, France. Electronic address:

Background: Calcium pyrophosphate dihydrate deposition disease (CPPD) has been reported to involve the spine, but few systematic studies have been published.

Objective: To further characterize the spinal involvement with CPPD by a review of CPPD patients hospitalized in a rheumatology department.

Methods: We retrospectively reviewed data for patients consecutively admitted with a diagnosis of CPPD in the rheumatology department of Lariboisière hospital in Paris, France over 5 years by using a standardized protocol and electronic case report forms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183043
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.009DOI Listing
October 2018
9 Reads

Poor long-term adherence to secondary penicillin prophylaxis in children with history of rheumatic fever.

Semin Arthritis Rheum 2018 Oct 16. Epub 2018 Oct 16.

Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva 4920235, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: Recurrent episodes of acute rheumatic fever may contribute to the development or worsening of rheumatic heart disease. Secondary penicillin prophylaxis (SPP) has been found to significantly reduce the incidence of rheumatic heart disease. This study sought to evaluate adherence to oral and intramuscular SPP in pediatric patients with rheumatic fever using real-world data spanning 10 years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183042
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.015DOI Listing
October 2018
8 Reads

How can we define low disease activity in systemic lupus erythematosus?

Semin Arthritis Rheum 2018 Oct 16. Epub 2018 Oct 16.

University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, 399 Bathurst St. 1E-410B, Toronto, Ontario M5T 2S8, Canada. Electronic address:

Background: In recent years, low disease activity emerged as a state that is associated with improved long-term outcomes in systemic lupus erythematosus (SLE). Our aim was to review the current concepts for low disease activity in SLE in order to serve as the basis of a future consensus for standardization.

Methods: The PubMed database was searched for relevant articles from inception up to July 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183048
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.013DOI Listing
October 2018
15 Reads
3.925 Impact Factor

Update of screening and diagnostic modalities for connective tissue disease-associated pulmonary arterial hypertension.

Semin Arthritis Rheum 2018 Oct 14. Epub 2018 Oct 14.

Division of Rheumatology, Scleroderma Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Objective: Pulmonary arterial hypertension (PAH) has high morbidity and mortality in connective tissue diseases (CTDs), especially systemic sclerosis (SSc). In this systematic review, we provide an update on screening measures for early detection of PAH in CTD.

Methods: Manuscripts published between July 2012 and October 2017, which incorporated screening measures to identify patients with PAH by right heart catheterization, were identified. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.10.010DOI Listing
October 2018
7 Reads

Regulatory B cells: New players in inflammatory and autoimmune rheumatic diseases.

Semin Arthritis Rheum 2018 Oct 15. Epub 2018 Oct 15.

Department of Rheumatology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa 41 110, Greece.

Objective: Regulatory B cells (Bregs) are a new subset of B cells with immunoregulatory functions, mainly through IL-10 production. Bregs suppress inflammatory Th1 and Th17 differentiation and induce Tregs suppressing autoimmune diseases. The aim of the study was to review the literature related to Bregs in autoimmune rheumatic diseases (ARDs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183049
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.007DOI Listing
October 2018
12 Reads

Combined pulmonary fibrosis and emphysema in systemic sclerosis: A syndrome associated with heavy morbidity and mortality.

Semin Arthritis Rheum 2018 Oct 13. Epub 2018 Oct 13.

Department of Internal Medicine, Service de Médecine Interne, Hôpital Cochin, Centre de Référence Maladies Systémiques Autoimmunes Rares d'Ile de France, DHU Authors (Autoimmune and Hormonal Diseases), Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. Electronic address:

Background: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) primarily due to tobacco smoking has been reported in connective tissue disease, but little is known about its characteristics in systemic sclerosis (SSc).

Methods: In this retrospective multi-center case-control study, we identified 36 SSc patients with CPFE, and compared them with 72 SSc controls with interstitial lung disease (ILD) without emphysema.

Results: Rate of CPFE in SSc patients with CT scan was 3. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.10.011DOI Listing
October 2018
8 Reads

Musculoskeletal rheumatic complications of immune checkpoint inhibitor therapy: A single center experience.

Semin Arthritis Rheum 2018 Oct 16. Epub 2018 Oct 16.

Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address:

Background: The use of immune checkpoint inhibition (ICI) has revolutionized cancer treatment. However, these medications are associated with significant and potentially debilitating immune-related adverse events (irAEs). While certain toxicities have been well studied, rheumatic complications have been less widely recognized and characterized. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183044
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.012DOI Listing
October 2018
8 Reads

Etanercept concentration and immunogenicity do not influence the response to Etanercept in patients with juvenile idiopathic arthritis.

Semin Arthritis Rheum 2018 Sep 17. Epub 2018 Sep 17.

Unité de Recherche Clinique Paris Descartes Necker Cochin, Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Tarnier, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, EA 7323, Paris, France.

Objective: To investigate the relationship of clinical response of Juvenile Idiopathic Arthritis (JIA) to etanercept (ETN) with ETN levels, and the presence of anti-drug antibodies to ETN (ADAb).

Methods: Prospective study of JIA patients under 18 years old. Clinical and pharmacological data were collected at two visits. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.09.002DOI Listing
September 2018
9 Reads

Added value of combining methotrexate with a biological agent compared to biological monotherapy in rheumatoid arthritis patients: A systematic review and meta-analysis of randomised trials.

Semin Arthritis Rheum 2018 Oct 9. Epub 2018 Oct 9.

Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Copenhagen, Denmark.

Objectives: To assess the efficacy and safety of methotrexate (MTX) in combination with an approved biological agent compared to biological monotherapy, in the management of patients with rheumatoid arthritis (RA).

Methods: MEDLINE, EMBASE, CENTRAL and other sources were searched for randomised trials evaluating a biological agent plus MTX versus the same biological agent in monotherapy. Co-primary outcomes were ACR50 and the number of patients who discontinued due to adverse events (AEs). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.10.002DOI Listing
October 2018
8 Reads

Effects of long-term exercise therapy on knee joint structure in people with knee osteoarthritis: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Oct 16. Epub 2018 Oct 16.

Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Corneel Heymanslaan 10, Building B3, 9000 Ghent, Belgium. Electronic address:

Objective: To investigate effects of long-term exercise therapy for people with knee osteoarthritis (OA) on radiographic disease severity and cartilage integrity (primary outcomes) as well as severity of bone marrow lesions (BMLs), synovitis and/or effusion (secondary outcomes).

Methods: We sourced randomized controlled trials in people with clinical and/or radiographic OA investigating the effect of land-based exercise therapy of > 6 months on radiographic disease severity and magnetic resonance imaging outcomes of cartilage integrity (morphology or composition) as well as BML, synovitis and/or effusion severity, when compared to no exercise. Two independent reviewers extracted data and assessed risk of bias. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183042
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.014DOI Listing
October 2018
13 Reads

Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort.

Semin Arthritis Rheum 2018 Oct 9. Epub 2018 Oct 9.

Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, Campus Box #7280, Chapel Hill, NC 27599-7280, United States; School of Medicine, University of North Carolina at Chapel Hill, 321 S Columbia St, Chapel Hill, NC 27516, United States. Electronic address:

Background/purpose: To update definitions of multiple joint osteoarthritis (MJOA), and to determine the frequency and impact of MJOA in a community-based cohort.

Methods: Following PRISMA guidelines and with the help of a professional research librarian, we performed a systematic review in Medline using the terms osteoarthritis, generalized, polyarticular, multiple joint, and multi-joint among others, to obtain articles related to MJOA. A total of 42 articles were included for data extraction based on multiple criteria including the requirement for a clearly stated definition of OA assessed at more than one body site. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.10.001DOI Listing
October 2018
2 Reads

Therapeutic tolerance in autoimmune disease.

Semin Arthritis Rheum 2018 12 28;48(3):558-562. Epub 2018 Sep 28.

Institute of Cellular Medicine, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. Electronic address:

Experimental immune tolerance induction, enabling tissues to be transplanted across animal strains, was first demonstrated in the 1950s. Therapeutic tolerance induction, whereby immune tolerance is used to treat or prevent transplant rejection, and as a treatment for autoimmunity, followed in the 1980s. Clinical translation has been slow but the pace of change is accelerating. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183059
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http://dx.doi.org/10.1016/j.semarthrit.2018.09.008DOI Listing
December 2018
8 Reads

Relationship between damage and mortality in juvenile-onset systemic lupus erythematosus: Cluster analyses in a large cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER).

Semin Arthritis Rheum 2018 Sep 27. Epub 2018 Sep 27.

Rheumatology Department, Complexo Hospitalario Universitario de Vigo, IRIDIS (Investigation in Rheumatology and Immune-Mediated Diseases) Group Instituto de Investigación Sanitaria Galicia Sur (IISGS), Vigo, Spain. Electronic address:

Objectives: To identify patterns (clusters) of damage manifestation within a large cohort of juvenile SLE (jSLE) patients and evaluate their possible association with mortality.

Methods: This is a multicentre, descriptive, cross-sectional study of a cohort of 345 jSLE patients from the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics Damage Index. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183033
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http://dx.doi.org/10.1016/j.semarthrit.2018.09.005DOI Listing
September 2018
8 Reads

Characteristics and clinical outcomes after treatment of a national cohort of PCR-positive Lyme arthritis.

Semin Arthritis Rheum 2018 Sep 28. Epub 2018 Sep 28.

EA 7290-Virulence bactérienne précoce, groupe borréliose de Lyme, CHRU de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France; Centre National de Référence des Borrelia, CHRU Strasbourg, France.

Objectives: To describe the clinical and microbiological characteristics and outcomes after antibiotic treatment of a national cohort of patients with Lyme arthritis confirmed by PCR testing on synovial fluid and by serology, when available.

Methods: Using the French National Reference Center for Borrelia database, patients with a positive PCR on synovial fluid for Borrelia were identified. Patient clinical and biological characteristics were reviewed from patient records. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.09.007DOI Listing
September 2018
6 Reads

Tumor necrosis factor inhibitors and risk of peripheral neuropathy in patients with rheumatic diseases.

Semin Arthritis Rheum 2018 Sep 27. Epub 2018 Sep 27.

Arthritis Research Canada, Richmond, BC, Canada; Division of Rheumatology, Department of Medicine, The University of British Columbia, Vancouver, Canada.

Importance: Tumor necrosis factor inhibitors (TNFi) are widely used in the treatment of a variety of autoimmune diseases. A number of case reports have linked TNFi to neurologic adverse events including peripheral neuropathy (PN) in patients with rheumatic diseases.

Objectives: To quantify the risk of peripheral neuropathy with TNFi in patients with rheumatic diseases. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.09.006DOI Listing
September 2018
6 Reads

Vascular calcification in patients with large-vessel vasculitis compared to patients with hyperlipidemia.

Semin Arthritis Rheum 2018 Sep 17. Epub 2018 Sep 17.

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 10 Center Drive, Building 10, Rm 216G, Bethesda, MD 20892, USA. Electronic address:

Objective: Calcification of the coronary arteries, aorta, and branch vessels can occur in both large-vessel vasculitis (LVV) and atherosclerosis. The study objective was to determine the location and amount of vascular calcification in patients with LVV versus hyperlipidemia (HLD) and to identify risk factors associated with vascular calcification in LVV.

Methods: Patients with giant cell arteritis (GCA), Takayasu's arteritis (TAK), and HLD underwent non-contrast computed tomography of the aorta and branch vessels. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.09.001DOI Listing
September 2018
3 Reads