19,292 results match your criteria Arthritis and rheumatism[Journal]


Obstetric outcomes in women with rheumatoid arthritis: Results from Nationwide Inpatient Sample Database 2003-2011.

Semin Arthritis Rheum 2019 Mar 23. Epub 2019 Mar 23.

University of Mississippi, 2500 North State Street, Jackson, MS 39232, United States.

Objective: Fertility is reduced in patients with Rheumatoid Arthritis due to unknown cause. Few studies have addressed pregnancy outcomes in RA. This study was undertaken to determine the frequency of complications occurring during pregnancy for women with RA and compare with the general obstetric population by using the largest inpatient care database. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.011DOI Listing
March 2019
1 Read

Glucocorticoids pharmacology and their application in the treatment of childhood-onset systemic lupus erythematosus.

Semin Arthritis Rheum 2019 Mar 16. Epub 2019 Mar 16.

Division of Rheumatology, Cincinnati Children's Hospital Medical Center, MLC 4010, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address:

Glucocorticoids are potent anti-inflammatory and immunosuppressant medications and remain the mainstay of systemic lupus erythematosus (SLE) therapy. The potency of a specific glucocorticoid, i.e. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.010DOI Listing
March 2019
1 Read

The CNS theory of osteoarthritis: Opportunities beyond the joint.

Semin Arthritis Rheum 2019 Mar 16. Epub 2019 Mar 16.

The Orthopaedic Research Institute of Queensland (ORIQL), Townsville 4812, Queensland, Australia; Heart, Trauma and Sepsis Research Laboratory, College of Medicine and Dentistry, James Cook University, 1 James Cook Drive, 4811, Queensland, Australia. Electronic address:

Osteoarthritis (OA) is a leading cause of global disability that affects more than half of the population over 65. It is not a single disease but a progressive, inflammatory- and immune-altering multi-disease that affects the whole joint. OA has many risk factors including age, obesity, gender, lifestyle, joint morphology, metabolic dysfunction and genetic disposition. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172193001
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http://dx.doi.org/10.1016/j.semarthrit.2019.03.008DOI Listing
March 2019
5 Reads

Imaging calcinosis in patients with systemic sclerosis by radiography, computerised tomography and magnetic resonance imaging.

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, UK.

Introduction: Objective outcome measures are needed to facilitate clinical trials of much needed treatments for calcinosis in systemic sclerosis (SSc). Our primary aim was to compare radiography, computed tomography (CT) and magnetic resonance imaging (MRI) to measure calcinotic lesions. Secondary objectives included to examine reproducibility of radiography and MRI, and inter-rater reliability of MRI. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.001DOI Listing

Comparative safety of abatacept in rheumatoid arthritis with COPD: A real-world population-based observational study.

Semin Arthritis Rheum 2019 Mar 16. Epub 2019 Mar 16.

Centre for Clinical Epidemiology, Lady Davis Institute - Jewish General Hospital, 3755 Cote Ste-Catherine, H-461, Montreal, Québec H3T 1E2, Canada; Division of Respiratory Medicine, Jewish General Hospital, Montreal, Québec, Canada.

Objective: The ASSURE randomized trial of abatacept safety in rheumatoid arthritis (RA) reported more frequent respiratory adverse events with abatacept among the subgroup of 54 patients with chronic obstructive pulmonary disease (COPD), leading to a label warning. We assessed the risk of adverse respiratory events associated with abatacept, compared with other biologic DMARDs (bDMARDs), among patients with RA and COPD in a real-world observational setting.

Methods: We formed a prevalent new-user cohort of patients with RA and COPD treated with bDMARDs within the US-based MarketScan databases from 2007 to 2014. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172193002
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http://dx.doi.org/10.1016/j.semarthrit.2019.03.007DOI Listing
March 2019
2 Reads

Inadequate reporting of concomitant medications in rheumatology randomized controlled trials of pharmacologic interventions.

Semin Arthritis Rheum 2019 Mar 16. Epub 2019 Mar 16.

Methods of Therapeutic Evaluation Of Chronic Diseases (METHODS) team, INSERM, UMR 1153, Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (CRESS), 1 Place du Parvis Notre Dame, 75004 Paris, France; Assistance Publique des Hôpitaux de Paris, Centre d'Epidémiologie Clinique, Hôpital Hôtel Dieu, Paris, France; Cochrane France, Paris, France; Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY, United States.

Objectives: To investigate how the use of pharmacologic concomitant medications (CMs) is planned and reported in rheumatology randomized controlled trials (RCTs).

Methods: We searched PubMed for RCTs on rheumatic diseases published in leading medical journals in the past 2years. CMs potentially influencing primary outcome(s) were identified by a panel of experts and included in the analysis. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.009DOI Listing

Risk of malignancy associated with use of tocilizumab versus other biologics in patients with rheumatoid arthritis: A multi-database cohort study.

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, 1620 Tremont Street, Suite 3030, Boston MA 02120, USA.

Objectives: To examine the rate of incident malignancies excluding non-melanoma skin cancer (NMSC) in patients with rheumatoid arthritis (RA) newly treated with tocilizumab versus other biologic drugs.

Methods: We conducted a cohort study using data from 3 U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183058
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http://dx.doi.org/10.1016/j.semarthrit.2019.03.002DOI Listing
March 2019
5 Reads

Characteristics of Behcet's Disease in the American Southwest.

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

DOIM-Rheum, MSC 10 5550, University of New Mexico Health Sciences Center, 5th FL ACC, Albuquerque, NM 87131, United States.

Objective: The goal of this study was to determine the characteristics of Behçet's disease (BD) in the American Southwest.

Material And Methods: This was a cross-sectional study of BD patients clinically encountered during a 2-year period. All subjects fulfilled the International Study Group criteria (ISG) or International Criteria for Behcet's Disease (ICBD). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.003DOI Listing
March 2019
2 Reads

Novel susceptibility alleles in HLA region for myositis and myositis specific autoantibodies in Korean patients.

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, 28 Yongun-dong, Chongno-gu, Seoul 110-744, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Medicine, Seoul National University, Seoul, South Korea. Electronic address:

Objectives: HLA genes are a major genetic risk factor for myositis and myositis specific antibodies (MSAs), exhibiting unique HLA backgrounds for myositis in different ethnic groups. This is the first large scale Korean study to genotype the HLA-DRB1 and -DPB1 alleles and to examine their association with myositis and MSAs.

Methods: HLA-DRB1 and HLA-DPB1 alleles and MSAs were examined in 179 patients with dermatomyositis (DM, n = 129) or polymyositis (PM, n = 50) and healthy controls (n = 800 for HLA-DRB1, n = 548 for HLA-DPB1). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.005DOI Listing
March 2019
4 Reads

Assessment of the psychometric properties of patient-reported outcomes of depression and anxiety in systemic lupus erythematosus.

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

University of Toronto Lupus Clinic, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases, EW, 1-412, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada. Electronic address:

Objectives: This study aimed to: 1) determine the prevalence of depression and anxiety in SLE patients using the Center for Epidemiological Studies-Depression Scale [CES-D], Hospital Anxiety and Depression Scale [HADS], and Beck Anxiety Inventory [BAI] questionnaires; 2) study the criterion validity, interpretability, and test-retest reliability of CES-D, HADS and BAI; and 3) evaluate their diagnostic accuracy when compared to the assessment of an independent psychiatric assessment using the Mini-International Neuropsychiatric Interview (MINI).

Methods: 159 consecutive SLE participants were screened for depression and anxiety using the CES-D, HADS, and BAI, and underwent the MINI. Sensitivity and specificity were evaluated against the MINI. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.004DOI Listing
March 2019
3.925 Impact Factor

Nonsurgical medical treatment in the management of pain due to lumbar disc prolapse: A network meta-analysis.

Semin Arthritis Rheum 2019 Mar 4. Epub 2019 Mar 4.

Department of cardiothoracic surgery, The First People's Hospital of YunNan Province, YunNan, China. Electronic address:

Background: Evaluate the comparative effectiveness of treatment strategies for patients with pain due to lumbar disc prolapse (LDP).

Methods: PubMed, EMBASE, and the Cochrane Database were searched through September 2017. Randomized controlled trials on LDP reporting on pain intensity and/or global pain effects which compared included treatments head-to-head, against placebo, and/or against conventional care were included. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.012DOI Listing
March 2019
3.925 Impact Factor

Spinal and sacroiliac involvement in SAPHO syndrome: A single center study of a cohort of 354 patients.

Semin Arthritis Rheum 2018 Sep 29. Epub 2018 Sep 29.

Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing 100730, China; Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing 100730, China; Medical Research Center of Orthopedics, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing 100730, China. Electronic address:

Objective: SAPHO syndrome is a highly heterogeneous disease with distinct treatment response. We report the largest cohort of SAPHO syndrome and explore its clinical classification with special interest in spinal and sacroiliac involvement.

Methods: A total of 354 patients with SAPHO syndrome were recruited in Peking Union Medical College Hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183013
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http://dx.doi.org/10.1016/j.semarthrit.2018.09.004DOI Listing
September 2018
4 Reads

Features and prognosis of giant cell arteritis in patients over 85years of age: A case-control study.

Semin Arthritis Rheum 2019 Mar 2. Epub 2019 Mar 2.

Department of Internal Medicine, Caen University Hospital, Caen, France.

Background: We examined the initial features, course, and prognosis of giant cell arteritis (GCA) in patients ≥ 85years of age (≥85 year) and compared them to those of younger patients.

Methods: The present retrospective study included all patients who were newly diagnosed with GCA in the Internal Departments of two French University Hospitals from 1976 or 1998 to 2017 and who were followed up for at least 6 months. Logistic regression analyses were conducted to identify baseline and prognostic characteristics associated with being ≥85 year. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.011DOI Listing
March 2019
1 Read

The mediating role of pain and function in the association between stiffness and quality of life in patients with axial spondyloarthritis.

Semin Arthritis Rheum 2019 Mar 2. Epub 2019 Mar 2.

Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore.

Objective: The relationship between stiffness and quality of life (QoL) remains unclear. We therefore aimed to examine the role of pain and function in linking stiffness and QoL in patients with axSpA.

Methods: We used cross-sectional data from a registry of axSpA patients in a tertiary referral centre to assess the links among stiffness, pain and function on QoL. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.010DOI Listing
March 2019
3.925 Impact Factor

Active viscosupplements for osteoarthritis treatment.

Semin Arthritis Rheum 2019 Feb 19. Epub 2019 Feb 19.

Group of Biomaterials, Department of Polymeric Nanomaterials and Biomaterials, Institute of Polymer Science and Technology (ICTP-CSIC), Madrid, Spain; Networking Biomedical Research Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

Objective: Osteoarthritis is a chronic, painful and disabling disease which prevalence is increasing in developing countries. Patients with osteoarthritis present a reduced synovial fluid viscoelasticity due to a reduction in concentration and molecular weight of hyaluronic acid. Currently, the main treatment used to restore the compromised rheological properties of synovial fluid is the viscosupplementation by hyaluronic acid injections that can be combined with oral anti-inflammatory drugs for pain relief. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.008DOI Listing
February 2019
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Systematic review of rheumatoid arthritis clinical studies: Suboptimal statistical analysis of radiological data.

Semin Arthritis Rheum 2019 Feb 21. Epub 2019 Feb 21.

Department of Epidemiology & Biostatistics, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.

Introduction: The distribution of progression scores in rheumatoid arthritis is highly skewed, requiring advanced statistical analysis techniques, with different techniques resulting in different outcomes.

Methods: Three databases were searched to identify rheumatoid arthritis clinical trials and observational studies that described radiographic analysis techniques, comparing at least two groups.

Results: Of 5980 identified papers, 225 were eligible for data extraction. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.009DOI Listing
February 2019
3 Reads

Myocardial fibrosis detected by magnetic resonance imaging, elevated U-CRP and higher mRSS are predictors of cardiovascular complications in systemic sclerosis (SSc) patients.

Semin Arthritis Rheum 2019 Feb 11. Epub 2019 Feb 11.

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15. Col. Belisario Dominguez Sección XVI, Tlalpan, Mexico City 14080, Mexico.

Introduction: In previous studies we showed that prevalence of myocardial fibrosis as assessed by late enhancement on cardiac MRI in SSc patients is 45% and is associated to diffuse disease (dcSSc) and lower left ventricle ejection fraction; microvascular damage defined as decreased perfusion on cardiac MRI after adenosine infusion, was also very frequent (79%). Our aim was to identify baseline characteristics associated to the development of cardiovascular outcomes (heart failure, coronary artery disease, arrhythmias, vasculopathy, elevated systolic pulmonary artery pressure and death) in SSc patients with previously documented myocardial fibrosis and microvascular damage.

Patients And Methods: We included 62 SSc patients who participated in the study of prevalence of myocardial fibrosis (2008-2010) and in our local SSc cohort. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.005DOI Listing
February 2019
2 Reads

Evolving treatment paradigms for rheumatoid arthritis: Translating comprehensive patient evaluations into personalized therapy.

Semin Arthritis Rheum 2019 Jan 23. Epub 2019 Jan 23.

Rheumatologist, Arizona Arthritis and Rheumatology Associates, PC, Adjunct Clinical Associate Professor, College of Health Sciences, Adjunct Assistant Professor, Division of Clinical Education, Midwestern University, Arizona College of Osteopathic Medicine, Phoenix, Arizona.

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.008DOI Listing
January 2019
2 Reads

Spontaneous vertebral fractures after denosumab discontinuation: A case collection and review of the literature.

Semin Arthritis Rheum 2019 Feb 15. Epub 2019 Feb 15.

Department of Rheumatology, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain.

Objective: Denosumab is an antiresorptive drug with demonstrated efficacy in the treatment of osteoporosis. However, discontinuation of this agent is associated with increased bone turnover and rapid bone loss, and more recently, with the development of vertebral fractures (VF) in some patients. Therefore, the aim of the study was to analyze the clinical characteristics, bone metabolism parameters and evolution of a group of patients who developed vertebral fractures after denosumab discontinuation. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.007DOI Listing
February 2019
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Treatment of refractory poor aPL-related obstetric outcomes with TNF-alpha blockers: Maternal-fetal outcomes in a series of 18 cases.

Semin Arthritis Rheum 2019 Feb 11. Epub 2019 Feb 11.

Reproductive Medicine Unit, Obstetric Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: No absolute data on the treatment of antiphospholipid antibodies (aPL) related to refractory obstetric complications exist to date. TNF-α play a major role in this disorder.

Objective: To assess the effectiveness of TNF-α blockers in 18 aPL-positive women with recurrent infertility after therapy with low-molecular-weight heparin (LMWH) plus aspirin (LDA) plus hydroxychloroquine (HCQ). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.006DOI Listing
February 2019
2 Reads

Efficacy of intra-articular hyaluronic acid injection in knee osteoarthritis in everyday life.

Semin Arthritis Rheum 2019 Feb 8. Epub 2019 Feb 8.

Rheumatology Department, Gabriel Montpied Teaching Hospital, 58 Rue Montalembert, 63003 Clermont-Ferrand, France. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.001DOI Listing
February 2019
1 Read

Anti-nuclear antibody development is associated with poor treatment response to biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis.

Semin Arthritis Rheum 2019 Feb 10. Epub 2019 Feb 10.

Center for Investigative Medical Sciences, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Clinical Research Center, Shizuoka General Hospital, Shizuoka 420-0881, Japan; Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan. Electronic address:

Background: It has been well known that TNF-α inhibitor (TNFi) treatment for patients with rheumatoid arthritis (RA) is associated with anti-nuclear antibody (ANA) development. We previously reported that ANA development was associated with poor outcomes of infliximab (IFX) treatment (1). However, no replication studies have been reported to date. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.003DOI Listing
February 2019
1 Read

Risk profiling for a refractory course of rheumatoid arthritis.

Semin Arthritis Rheum 2019 Feb 8. Epub 2019 Feb 8.

Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address:

Background: Despite modern therapeutics and treatment strategies, a subset of rheumatoid arthritis (RA) patients remains insufficiently responsive to multiple therapies. Here, we identify predictors of such refractory RA ("reRA").

Methods: Patients from a longitudinal academic clinical database with reRA (defined as failing to reach the treatment target of at least low disease activity with ≥3 DMARD courses, including ≥1 biological, over a total of ≥18 months) were compared to patients who did respond within the first two treatments (treatment amenable RA, "taRA"). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.004DOI Listing
February 2019

Post-traumatic stress disorder and serum cytokine and chemokine concentrations in patients with rheumatoid arthritis.

Semin Arthritis Rheum 2019 Feb 8. Epub 2019 Feb 8.

Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, United States; University of Nebraska Medical Center, Omaha, NE, United States. Electronic address:

Objective: Although post-traumatic stress disorder (PTSD) is identified as a risk factor in the development of rheumatoid arthritis (RA), associations of PTSD with disease progression are less clear. To explore whether PTSD might influence disease-related measures of systemic inflammation in RA, we compared serum cytokine/chemokine (cytokine) concentrations in RA patients with and without PTSD.

Methods: Participants were U. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183061
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http://dx.doi.org/10.1016/j.semarthrit.2019.02.002DOI Listing
February 2019
8 Reads

Abatacept initiation in rheumatoid arthritis and the risk of serious infection: A population-based cohort study.

Semin Arthritis Rheum 2019 Jan 25. Epub 2019 Jan 25.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Cote Ste-Catherine, H-461 Montreal, Québec H3T 1E2, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Québec, Canada. Electronic address:

Objective: To assess whether abatacept as initial biologic disease-modifying antirheumatic drug (DMARD) in the treatment of rheumatoid arthritis is associated with an increased risk of serious infections, including bone and joint, gastrointestinal, respiratory tract, skin and soft tissue, and urinary tract, when compared with other biologic DMARDs.

Methods: We performed a population-based cohort study among patients newly-treated with biologic DMARDs within the US-based Truven MarketScan® population and Supplemental US Medicare from 2007 to 2014. Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of serious infections requiring hospitalisation associated with initiation of abatacept, compared with initiation of other bDMARDs, after controlling for age and deciles of the propensity score. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.009DOI Listing
January 2019
2 Reads

Damage indices in rheumatic diseases: A systematic review of the literature.

Semin Arthritis Rheum 2019 Jan 17. Epub 2019 Jan 17.

The University of Melbourne, St Vincent's Hospital, Melbourne, Australia; St Vincent's Hospital, Melbourne, Australia. Electronic address:

Objective: To review the current literature, and evaluate the psychometric properties of disease damage indices in rheumatic diseases.

Methods: A search of Medline, EMBASE, and Cochrane Library databases was performed to June 2018 to identify damage indices in all systemic rheumatic diseases. Articles were included in a systematic review if indices were composite (multi-organ) in nature and if adequate detail on methodology was described. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.007DOI Listing
January 2019
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Cost-effectiveness of sequential treatment with abaloparatide vs. teriparatide for United States women at increased risk of fracture.

Semin Arthritis Rheum 2019 Jan 10. Epub 2019 Jan 10.

Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium; Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.

Objectives: There is emerging evidence supporting sequential therapy with an osteoanabolic followed by an antiresorptive in patients at high-risk of fragility fractures. This study assessed the cost-effectiveness of sequential treatment with abaloparatide (ABL) followed by alendronate (ALN) [(ABL/ALN)] compared with teriparatide (TPTD) followed by ALN (TPTD/ALN).

Methods: A previously validated Markov microsimulation model was adapted to estimate the cost-effectiveness of sequential ABL/ALN compared with sequential TPTD/ALN and no treatment with a lifetime horizon from the US payer perspective. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.006DOI Listing
January 2019
2 Reads

Type 2 diabetes mellitus and osteoarthritis.

Semin Arthritis Rheum 2019 Jan 11. Epub 2019 Jan 11.

Division of Diabetes, Nutrition and Metabolic Disorders and Clinical Pharmacology Unit, Department of Medicine, University of Liège, CHU Liège, Sart Tilman B35, B-4000 Liège, Belgium.

Objectives: Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases that frequently co-exist, along with overweight/obesity. While the mechanical impact of excess body weight on joints may explain lower limb OA, we sought to explore whether T2DM is linked to OA outside of excess weight and whether T2DM may play a role in OA pathophysiology. The consequence of T2DM on OA outcomes is a question of research interest. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183058
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http://dx.doi.org/10.1016/j.semarthrit.2019.01.005DOI Listing
January 2019
14 Reads

Prevalence and discrimination of OMERACT-defined elementary ultrasound lesions of gout in people with asymptomatic hyperuricaemia: A systematic review and meta-analysis.

Semin Arthritis Rheum 2019 Jan 11. Epub 2019 Jan 11.

Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Objectives: Ultrasound lesions of gout have been described in people with asymptomatic hyperuricemia. However, the anatomical sites and ultrasound lesions most frequently involved in asymptomatic hyperuricemia have not yet been established. This systematic review and meta-analysis aimed to determine the prevalence of the Outcome Measures in Rheumatology (OMERACT) elementary ultrasound lesions of gout (double contour, aggregates, tophus, erosion) at various sites in people with asymptomatic hyperuricemia and to determine which sites and lesions discriminate from people with normouricemia. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.004DOI Listing
January 2019
3 Reads

The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life.

Semin Arthritis Rheum 2018 Dec 28. Epub 2018 Dec 28.

Department of Rheumatology, Guy's and St Thomas' NHS Trust, 4th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, UK; Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, 1st Floor, New Hunt's House, Guy's Campus, King's College London, Great Maze Pond, London, UK.

Objective: Treat-to-target in rheumatoid arthritis (RA) recommends targeting remission, with low disease activity (LDA) being an alternative goal. When deciding to target remission or LDA, important considerations are the likelihood of attaining them, and their impacts on function and health-related quality of life (HRQoL). We have addressed this by studying: (a) the frequency of remission and LDA/remission; (b) DAS28-ESR trends after remission; (c) ability of remission vs. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.12.006DOI Listing
December 2018
1 Read

Identifying lupus patients in electronic health records: Development and validation of machine learning algorithms and application of rule-based algorithms.

Semin Arthritis Rheum 2019 Jan 4. Epub 2019 Jan 4.

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, United States.

Objective: To utilize electronic health records (EHRs) to study SLE, algorithms are needed to accurately identify these patients. We used machine learning to generate data-driven SLE EHR algorithms and assessed performance of existing rule-based algorithms.

Methods: We randomly selected subjects with ≥ 1 SLE ICD-9/10 codes from our EHR and identified gold standard definite and probable SLE cases by chart review, based on 1997 ACR or 2012 SLICC Classification Criteria. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.002DOI Listing
January 2019
1 Read

Commentary on the article: Hughes M & Pauling JD. Exploring the patient experience of digital ulcers in systemic sclerosis. Semin Arthritis Rheum. 2018 Aug 11. pii: S0049-0172(18)30354-8. doi: 10.1016/j.semarthrit.2018.08.001. [Epub ahead of print] Review.

Semin Arthritis Rheum 2018 Dec 29. Epub 2018 Dec 29.

Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183075
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http://dx.doi.org/10.1016/j.semarthrit.2018.12.005DOI Listing
December 2018
9 Reads

Ocular involvement in systemic sclerosis: A systematic literature review, it's not all scleroderma that meets the eye.

Semin Arthritis Rheum 2018 Dec 28. Epub 2018 Dec 28.

Department of Internal Medicine, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium; Department of Rheumatology, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Corneel Heymanslaan 10, 9000 Ghent, Belgium. Electronic address:

Objectives: Systemic sclerosis (SSc) is a rare and complex autoimmune disorder characterized by microvascular damage and progressive fibrosis which affects the skin and multiple other organs. Much of the published data concerning SSc and the eye consists of single case reports or small case studies. This systematic review aims to provide an overview of the current level of evidence for SSc-related ocular changes. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.12.007DOI Listing
December 2018
4 Reads

Predicting flares in patients with stable systemic lupus erythematosus.

Semin Arthritis Rheum 2019 Jan 5. Epub 2019 Jan 5.

Division of Rheumatology, Department of Medicine, National University Hospital of Singapore, Level 10, NUHS Tower Block, 1E Kent Ridge Road, 119228, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Objectives: Data on flares in Asian patients with systemic lupus erythematosus (SLE) are scarce. Here, we aim to identify the baseline predictors of flares in a cohort of Southeast Asian patients with SLE.

Methods: Consecutive adult patients with prevalent SLE according to the 1997 ACR or 2012 SLICC criteria were enrolled and followed three-monthly. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.001DOI Listing
January 2019
16 Reads

A better look at rheumatoid arthritis: Using imaging to improve patient outcomes.

Semin Arthritis Rheum 2019 02 21;48(4):763. Epub 2018 Dec 21.

Associate Professor of Medicine, Department of Medicine, Allergy/Immunology & Rheumatology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183077
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http://dx.doi.org/10.1016/j.semarthrit.2018.12.004DOI Listing
February 2019
12 Reads

Tocilizumab in giant cell arteritis. Observational, open-label multicenter study of 134 patients in clinical practice.

Semin Arthritis Rheum 2019 Jan 5. Epub 2019 Jan 5.

Departments of Rheumatology, Internal Medicine and Pathology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Spain. Electronic address:

Objective: Tocilizumab (TCZ) has shown efficacy in clinical trials on giant cell arteritis (GCA). Real-world data are scarce. Our objective was to assess efficacy and safety of TCZ in unselected patients with GCA in clinical practice Methods: Observational, open-label multicenter study from 40 national referral centers of GCA patients treated with TCZ due to inefficacy or adverse events of previous therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183057
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http://dx.doi.org/10.1016/j.semarthrit.2019.01.003DOI Listing
January 2019
17 Reads

Safety of combination therapy with two bDMARDs in patients with rheumatoid arthritis: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Dec 18. Epub 2018 Dec 18.

Rheumatology Department, Maison Blanche Hospital, Reims University Hospitals, 45 Rue Cognacq-Jay, Reims 51092, France; Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, 51095 Reims, France. Electronic address:

Objectives: We performed a systematic review and meta-analysis of the current literature to assess the safety of combining two biologic disease-modifying antirheumatic drugs (bDMARDs) in the treatment of rheumatoid arthritis (RA).

Methods: We systematically searched for controlled studies evaluating safety in patients with RA treated with two bDMARDs independently of dose-regimen. Databases used were MEDLINE (via Pubmed), EMBase, Cochrane Library, Scopus, ClinicalTrials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183065
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http://dx.doi.org/10.1016/j.semarthrit.2018.12.003DOI Listing
December 2018
11 Reads

The efficacy of dietary intervention on gastrointestinal involvement in systemic sclerosis: A systematic literature review.

Semin Arthritis Rheum 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK; Royal National Hospital for Rheumatic Diseases (part of Royal United Hospitals Bath NHS Foundation Trust), Upper Borough Walls, BA1, 1RL Bath, UK. Electronic address:

Background: Gastrointestinal involvement in systemic sclerosis is common and a major cause of disease-related morbidity. Patients increasingly enquire about dietary modifications that may help with gastrointestinal symptoms. Many clinical practice reviews and treatment guidelines make specific reference to dietary modifications in the management of gastrointestinal involvement in systemic sclerosis. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.12.001DOI Listing
December 2018
2 Reads

Sample size calculations for detecting disease-modifying osteoarthritis drug effects on the incidence of end-stage knee osteoarthritis in clinical trials: Data from the Osteoarthritis Initiative.

Semin Arthritis Rheum 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box #406, Boston, MA 02111, USA.

Objective: We previously published data representing calculations for sample sizes assuming that the reduction of the incidence of knee joint replacement (KJR) would be an endpoint to prove efficacy of a disease-modifying drug in osteoarthritis (DMOAD). The sample sizes required for such hypothetical studies appeared to be high, rendering those studies unrealistic in the clinical research setting for practical reasons. The purpose of this work is to calculate sample sizes for hypothetical trials for DMOAD efficacy using a proxy for reaching end-stage knee osteoarthritis (esKOA) as an endpoint. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183044
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http://dx.doi.org/10.1016/j.semarthrit.2018.12.002DOI Listing
December 2018
10 Reads

Characterization of indigenous community engagement in arthritis studies conducted in Canada, United States of America, Australia and New Zealand.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

Departments of Medicine and Community Health Sciences, University of Calgary and Rheumatologist, Alberta Health Services, 3330 Hospital Drive NW, T2N 4N1, Calgary, Alberta, Canada. Electronic address:

Background: Research adhering to community engagement processes leads to improved outcomes. The level of Indigenous communities' engagement in rheumatology research is unknown.

Objective: To characterize the frequency and level of community engagement reporting in arthritis studies conducted in Australia (AUS), Canada (CAN), New Zealand (NZ) and the United States of America (USA). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.009DOI Listing
December 2018
1 Read

Secondary thrombotic microangiopathy in systemic lupus erythematosus and antiphospholipid syndrome, the role of complement and use of eculizumab: Case series and review of literature.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 865 Northern Boulevard, Suite 302, Great Neck, NY 11021, USA.

Introduction: Thrombotic microangiopathy (TMA) is a life-threatening, albeit infrequent, complication of systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS). Recommendations for the treatment of SLE- and APS-related secondary TMA are currently based solely on case reports and expert opinion. Unfortunately, interventions may not yield timely results or effectively halt the progression of TMA. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.005DOI Listing
December 2018
4 Reads

Rheumatologic symptoms and checkpoint inhibitor - Stop pain or stop cancer?

Semin Arthritis Rheum 2018 Dec 5. Epub 2018 Dec 5.

Hospital Santo Antonio, Salvador, Bahia, Brazil; Universidade Salvador (UNIFACS), Salvador, Bahia, Brazil.

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.003DOI Listing
December 2018
1 Read

Update of the evidence based, interdisciplinary guideline for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

The Society for Paediatric Rheumatology (GKJR), Germany.

Background: Uveitis in juvenile idiopathic arthritis (JIAU) is frequently associated with the development of complications and visual loss. Topical corticosteroids are the first line therapy, and disease modifying anti-rheumatic drugs (DMARDs) are commonly used. However, treatment has not been standardized. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.004DOI Listing
December 2018
3 Reads

Recapture and improved outcome of pegloticase response with methotrexate-A report of two cases and review of the literature.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

Osteoporosis and Arthritis Care, Henderson, NV, United States.

Introduction: Pegloticase is a PEGylated uric acid specific enzyme indicated for the treatment of refractory gout. Anti-pegloticase antibodies contribute to high discontinuation rates, increased risk of infusion reactions, and early loss of drug efficacy.

Objective: To describe the use of methotrexate to recapture function of pegloticase after development of anti-drug antibodies while treating gout. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.006DOI Listing
December 2018
2 Reads

Pulmonary arterial hypertension in adult-onset Still's disease: A case series and systematic review of the literature.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

Departments of Rheumatology, Hospital Son Llàtzer, Palma de Mallorca, Spain.

Objective: To investigate the prevalence, clinical characteristics and prognosis of pulmonary arterial hypertension (PAH) in adult onset Still's disease (AOSD).

Methods: We retrospectively reviewed all patients with AOSD diagnosed during a 33-year period in 2 referral tertiary care hospitals, selecting for analysis those who presented PAH confirmed as by right heart catheterization. A systematic review of the literature (PubMed 1990 to July 2018) was also performed, in order to determine the prognosis and the most appropriate treatment strategy for this complication. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.007DOI Listing
December 2018
2 Reads

Inpatient prevalence, burden and comorbidity of Takayasu's arteritis: Nationwide inpatient sample 2013-2014.

Semin Arthritis Rheum 2018 Dec 3. Epub 2018 Dec 3.

Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Jacksonville, FL, USA.

Objectives: To investigate the inpatient prevalence, characteristics and comorbidities of patients admitted with Takayasu's arteritis (TAK) in the United States (US).

Methods: Patients with TAK were identified within the Nationwide Inpatient Sample (NIS) database of the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on patient characteristics, comorbidities, resource utilization and expenditures was collected. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.008DOI Listing
December 2018
4 Reads
3.925 Impact Factor

Positron emission tomography costs less to patients than conventional screening for malignancy in dermatomyositis.

Semin Arthritis Rheum 2018 Nov 2. Epub 2018 Nov 2.

Penn State Hershey Medical Center, Department of Dermatology, 500 University Drive, Hershey, PA, USA. Electronic address:

Background: Dermatomyositis (DM) is associated with malignancy and interstitial lung disease. Many malignancies associated with DM occur in organs not routinely screened by national guidelines; thus, best screening practices are still debated. Positron emission tomography (PET) has been suggested as a single study alternative to more complex screening panels and may also be valuable in detecting interstitial lung disease progression. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.10.021DOI Listing
November 2018
2 Reads

Corrigendum to "Psoriatic arthritis disease activity during pregnancy and the first-year postpartum" [Semin. Arthritis Rheum. 46 (6) (2017) 740-745].

Semin Arthritis Rheum 2019 02 24;48(4):764. Epub 2018 Nov 24.

Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Psoriatic Arthritis Program, Center for Prognostic Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.001DOI Listing
February 2019
7 Reads

The role of C-reactive protein as a predictor of treatment response in patients with ankylosing spondylitis.

Semin Arthritis Rheum 2018 Nov 2. Epub 2018 Nov 2.

Pfizer Innovative Health, Global Medical Affairs Pfizer Inc, Collegeville, PA, United States.

Objectives: To determine whether C-reactive protein (CRP) level is predictive of response to tumor necrosis factor-α blocker treatment in patients with ankylosing spondylitis (AS) and whether there is an optimal CRP range for treatment initiation.

Methods: In this post hoc analysis, data on etanercept-treated patients with AS were pooled from four randomized trials. Week 12 responses (ASAS20, ASAS50, ASDAS-CRP < 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183023
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http://dx.doi.org/10.1016/j.semarthrit.2018.10.019DOI Listing
November 2018
26 Reads

Contemporary epidemiology of systemic sclerosis: A population-based cohort study in the United Kingdom.

Semin Arthritis Rheum 2018 Nov 10. Epub 2018 Nov 10.

Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Almirante 28, Madrid 28004, Spain; Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain.

Objective: To estimate the contemporary epidemiology of systemic sclerosis (SSc) in the UK and to explore the validity of using The Health Improvement Network (THIN) primary care database to study SSc.

Methods: 4,520,299 individuals (2000-2012) aged 1-99 years were followed to identify potential incident cases of SSc; potential prevalent cases were identified at start of follow-up. Patient profiles, including free-text comments, were manually reviewed to verify cases of SSc, and case validation was undertaken for a sample (n = 100) using questionnaires to primary care physicians. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.002DOI Listing
November 2018
14 Reads