19,180 results match your criteria Arthritis and rheumatism[Journal]


Malignancy development risk in psoriatic arthritis patients undergoing treatment: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 May 23. Epub 2018 May 23.

Departments of Rheumatology and Clinical Immunology Center, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, #41 Damucang xidan, Beijing, China.

Background: Psoriatic arthritis (PsA) is a chronic and seronegative inflammatory arthritis occurring in patients with psoriasis. The current knowledge about the risk of malignancy associated with psoriatic arthritis (PsA) patients undergoing therapy is controversial. We focused on the relationship between malignancy and therapy and undertook a meta-analysis to address this issue. Read More

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Myositis as an adverse event of immune checkpoint blockade for cancer therapy.

Semin Arthritis Rheum 2018 May 18. Epub 2018 May 18.

Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Objectives: Immune checkpoint inhibitors (ICIs) can successfully treat cancer, but their use can be hindered by serious immune-related adverse events. We report six patients receiving ICIs who presented with de novo myositis.

Methods: We identified patients with myositis who were receiving ICIs between January 2004 and September 2016 at The University of Texas MD Anderson Cancer Center. Read More

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May 2018
1 Read

Predictors of positive F-FDG PET/CT-scan for large vessel vasculitis in patients with persistent polymyalgia rheumatica.

Semin Arthritis Rheum 2018 May 18. Epub 2018 May 18.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain; University of Cantabria, School of Medicine, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address:

Objective: Polymyalgia rheumatica (PMR) is often the presenting manifestation of giant cell arteritis (GCA). Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scan often discloses the presence of large vessel vasculitis (LVV) in PMR patients. We aimed to identify predictive factors of a positive PET/CT scan for LVV in patients classified as having isolated PMR according to well-established criteria. Read More

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May 2018
1 Read

Frequency, treatment, evolution, and factors associated with the presence of tracheobronchial stenoses in granulomatosis with polyangiitis. Retrospective analysis of a case series from a single respiratory referral center.

Semin Arthritis Rheum 2018 May 16. Epub 2018 May 16.

Primary Systemic Vasculitides Clinic, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, Col. Sección XVI, C.P., 14080, Mexico City, Mexico. Electronic address:

Objectives: Granulomatosis with polyangiitis-a primary systemic vasculitis-most frequent manifestations are respiratory. Airway disease can present with stenosis, and although subglottic stenosis (SGS) is well described, narrowing distal to the glottis has been more recently the focus of reporting. Our objectives, therefore, are to describe the frequency, characteristics, and treatment of tracheobronchial stenoses (TBS) in granulomatosis with polyangiitis (GPA) at our institution, a national referral center for respiratory diseases. Read More

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Myeloperoxidase-ANCA-positive granulomatosis with polyangiitis is a distinct subset of ANCA-associated vasculitis: A retrospective analysis of 455 patients from a single center in China.

Semin Arthritis Rheum 2018 May 9. Epub 2018 May 9.

Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China.

Objective: Antineutrophil cytoplasmic antibody (ANCA) directed to proteinase 3 (PR3) used to be considered the serologic marker for granulomatosis with polyangiitis (GPA). However, patients with myeloperoxidase (MPO)-ANCA positive GPA have been increasingly reported. The aim of this study was to analyze the clinical and pathological characteristics and outcome of Chinese patients with MPO-ANCA positive GPA. Read More

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Arterial lesions in giant cell arteritis: A longitudinal study.

Semin Arthritis Rheum 2018 May 9. Epub 2018 May 9.

Division of Rheumatology, St. Joseph's Healthcare, McMaster University, Hamilton, ON, Canada.

Objectives: To evaluate large-vessel (LV) abnormalities on serial imaging in patients with giant cell arteritis (GCA) and discern predictors of new lesions.

Methods: Clinical and imaging data from patients with GCA (including subjects diagnosed by LV imaging) enrolled in a prospective, multicenter, longitudinal study and/or a randomized clinical trial were included. New arterial lesions were defined as a lesion in a previously unaffected artery. Read More

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May 2018
1 Read

Effect of treat-to-target strategies on bone erosion progression in early rheumatoid arthritis: An HR-pQCT study.

Semin Arthritis Rheum 2018 May 3. Epub 2018 May 3.

Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. Electronic address:

Objectives: To investigate the efficacy of two tight-control treatment strategies aimed at simplified disease activity score [SDAI] remission (SDAI ≤ 3.3) compared to DAS28 remission (DAS28 < 2.6) on progression of bone erosions in early rheumatoid arthritis (ERA) patients using high-resolution peripheral quantitative computed tomography (HR-pQCT). Read More

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Identifying MRI-detected inflammatory features specific for rheumatoid arthritis: two-fold feature reduction maintains predictive accuracy in clinically suspect arthralgia patients.

Semin Arthritis Rheum 2018 May 1. Epub 2018 May 1.

Department of Radiology, Division of Image Processing, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

Objective: MRI-detected inflammation is considered of diagnostic value for rheumatoid arthritis (RA), but its evaluation involves a time-consuming scoring of 61 joint-level features. It is not clear, however, which of these features are specific for RA and whether evaluating a subset of specific features is sufficient to differentiate RA patients. This study aimed to identify a subset of RA-specific features in a case-control setting and validate them in a longitudinal cohort of arthralgia patients. Read More

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May 2018
1 Read

Gout of the axial joint-A patient level systemic review.

Semin Arthritis Rheum 2018 May 1. Epub 2018 May 1.

Department of Rheumatology, Shandong University, Qilu Hospital, 758 Hefei Rd, Qingdao, China; Qingdao Key Laboratory of Mitochondrial Medicine, Qingdao, China.

Objective: Gout is the osteoarticular expression of hyperuricemia, resulting from excessive production and/or insufficient elimination of uric acid. Emerging case reports described the deposition of mono sodium urate in the spine as a rare manifestation of gout, we aimed in revealing the full picture of reported axial joint gout (AJG).

Methods: We performed a systemic patient level review focused on characteristics of reported cases of axial joint involvement in gout. Read More

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May 2018
1 Read

Statin use and mortality in gout: A general population-based cohort study.

Semin Arthritis Rheum 2018 Mar 17. Epub 2018 Mar 17.

Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Bulfinch 165, Boston, MA 02114.

Objectives: Gout is associated with a higher risk of cardiovascular disease and premature mortality. We examined the potential survival benefit of statin use among gout patients in the general population.

Methods: We performed an incident user cohort study with time-stratified propensity score matching using a database representative of the UK general population between January 1999 and December 2014. Read More

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March 2018
2 Reads

Ustekinumab for refractory giant cell arteritis: A prospective 52-week trial.

Semin Arthritis Rheum 2018 Apr 22. Epub 2018 Apr 22.

Centre for Arthritis and Rheumatic Diseases, St Vincent's University Hospital, Dublin Academic Medical Centre, Elm Park, Dublin 4, Ireland.

Objectives: Giant cell arteritis (GCA) is the most common form of systemic vasculitis. Glucocorticoids are an effective treatment but have significant adverse events and relapses are common. Interleukins 12 (IL-12) and 23 (IL-23) stimulate T1 and T17 responses and are implicated in the pathogenesis of GCA. Read More

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April 2018
3 Reads

Biologics in SAPHO syndrome: A systematic review.

Semin Arthritis Rheum 2018 Apr 17. Epub 2018 Apr 17.

Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Patras, Greece.

Background: The SAPHO syndrome is a relatively rare clinical entity characterized by a wide range of dermatological and musculoskeletal manifestations. Biologics have been used in cases refractory to conventional treatment.

Methods: We present herein a patient with refractory to treatment SAPHO syndrome who exhibited a dramatic and fast response to IL-17 blockade. Read More

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Medications received by patients with juvenile dermatomyositis.

Semin Arthritis Rheum 2018 Mar 28. Epub 2018 Mar 28.

Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Building 10, Rm 4-2352, MSC 1301, 10 Center Drive, Bethesda, MD 20892-1301. Electronic address:

Objective: Few controlled studies are available to guide treatment decisions in juvenile dermatomyositis (JDM). This study evaluated therapies received, changes of treatment over time, and factors associated with medication choices in JDM.

Methods: We performed a retrospective analysis of the number and type of therapies and duration of treatment for 320 patients with JDM enrolled in a North American registry. Read More

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March 2018
2 Reads

High prevalence of hidradenitis suppurativa symptoms in axial spondyloarthritis patients: A possible new extra-articular manifestation.

Semin Arthritis Rheum 2018 Mar 20. Epub 2018 Mar 20.

Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands; Department of Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands.

Background: Spondyloarthritis (SpA), a chronic inflammatory, rheumatic disease, and hidradenitis suppurativa (HS), a chronic, debilitating, inflammatory skin disease, share several clinical and pathophysiological features, such as the association with inflammatory bowel disease and elevated cytokine levels IL-17 and TNF-α. Recently, SpA was reported to be more prevalent (2.3-28. Read More

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March 2018
5 Reads

A systematic review of viral exposures as a risk for rheumatoid arthritis.

Semin Arthritis Rheum 2018 Mar 21. Epub 2018 Mar 21.

Schulich School of Medicine & Dentistry, Western University, Division Head Rheumatology, St Joseph Health Care, 268 Grosvenor St., London, ON N6A 4V2, Canada. Electronic address:

Objective: Different viral exposures have been implicated in the etiology of rheumatoid arthritis (RA). Evidence relating to the association between putative viral exposures and the development of RA was reviewed.

Methods: A systematic literature search was conducted using MEDLINE-OVID, EMBASE-OVID, PUBMED and Cochrane library databases. Read More

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March 2018
2 Reads

Long-term effect of B-cells depletion alone as rescue therapy for severe thrombocytopenia in primary antiphospholipid syndrome.

Semin Arthritis Rheum 2018 Apr 11. Epub 2018 Apr 11.

Center of Research of Immunopathology and Rare Diseases-Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, S. Giovanni Bosco Hospital, University of Turin, Piazza del Donatore di Sangue 3, 10154 Turin, Italy; UOSD Hematology and Thrombosis Unit, S. Giovanni Bosco Hospital, Turin, Italy.

Objectives: To investigate the long-term effect of B-cell depletion therapy with Rituximab (RTX) alone as rescue therapy in primary antiphospholipid syndrome (PAPS) patients with severe thrombocytopenia.

Methods: We retrospectively retrieved data from patients who met the following inclusion criteria: (a) persistent antiphospholipid antibodies (aPL) positivity and fulfilled the Sydney criteria for PAPS (b) presented with severe thrombocytopenia (platelets <50,000/mm) (c) were treated with RTX as a rescue therapy (d) had at least 1 year of follow-up after B-cells depletion therapy.

Results: This retrospective study included 6 consecutive female PAPS patients [median age 49. Read More

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April 2018
2 Reads

Comment on: Efficacy of Curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Apr 11. Epub 2018 Apr 11.

Bone and Cartilage Research Unit, Arthropole Liège, University of Liège, Institute of Pathology, CHU Sart Tilman, 4000 Liège, Belgium.

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April 2018
6 Reads

High rates of tuberculin skin test positivity due to methotrexate therapy: False positive results?

Semin Arthritis Rheum 2018 Mar 29. Epub 2018 Mar 29.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Mayo Clinic Center for Tuberculosis, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.

Rationale: The tuberculin skin test (TST) and interferon γ release assays (IGRAs) are commonly used for latent tuberculosis infection (LTBI) screening. Unexpectedly high TST positivity rates have been reported in patients with rheumatic diseases, and methotrexate is frequently used in this population. We hypothesized that methotrexate use could be associated with false-positive TST results. Read More

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March 2018
2 Reads

Trends of Informed Consent forms for industry-sponsored clinical trials in rheumatology over a 17-year period: Readability, and assessment of patients' health literacy and perceptions.

Semin Arthritis Rheum 2018 Mar 16. Epub 2018 Mar 16.

Unidad de Investigación en Enfermedades Cronico-Degenerativas, Guadalajara, México; Universidad Autonoma de Guadalajara, Guadalajara, México. Electronic address:

Objective: To assess trends in the length and readability of informed consent forms (ICFs) for industry-sponsored multinational clinical trials (RCTs) in rheumatology over a 17-year period. Additionally, to assess the health literacy (HL) and perceptions of ICFs among participants of current RCTs.

Methods: The readability of ICFs conducted at an outpatient rheumatology clinic between 1999 and 2016 were assessed using the INFLESZ scale. Read More

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March 2018
3 Reads

Patterns of peripheral joint involvement in psoriatic arthritis-Symmetric, ray and/or row?

Semin Arthritis Rheum 2018 Mar 9. Epub 2018 Mar 9.

Centre for Prognosis Studies in The Rheumatic Diseases, Krembil Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: We sought to examine whether joint involvement in psoriatic arthritis (PsA) follows a symmetric, ray, and/or row pattern using longitudinal data.

Methods: Data on activity and clinical damage of the joints of the hands and feet were obtained from a PsA cohort. For each analysis (symmetry, ray or row) for each outcome (joint damage and activity) expected values for table cells under the null hypothesis that joints progress independently to damage or activity were calculated based on a logistic regression model with patient level random effects for the probability of involvement developing between clinic visits. Read More

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March 2018
1 Read

The use of routinely collected patient-reported outcome measures in rheumatoid arthritis.

Semin Arthritis Rheum 2018 Mar 15. Epub 2018 Mar 15.

Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada; Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada. Electronic address:

This study systematically reviewed commonly used patient-reported outcome measures (PROMs) for rheumatoid arthritis (RA), routinely collected in clinical practice, and evaluated objectives of their use. An additional survey conducted among identified RA registries provided additional information about collection of PROMs. Medline Ovid and Embase were searched for observational studies using data of RA registries/cohorts, published between 2011 and 2016. Read More

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March 2018
2 Reads

Practical suggestions on intravenous iloprost in Raynaud's phenomenon and digital ulcer secondary to systemic sclerosis: Systematic literature review and expert consensus.

Semin Arthritis Rheum 2018 Apr 4. Epub 2018 Apr 4.

Department of Experimental and Clinical Medicine, University of Florence & Department of Geriatric Medicine, Division of Rheumatology AOUC, Florence, Italy.

Background: Systemic sclerosis (SSc) is an autoimmune chronic disease characterized by vascular impairment, immune dysfunction and collagen deposition. Raynaud's phenomenon (RP) and digital ulcers (DU) are prominent features of SSc. Intravenous (IV) iloprost (ILO), according to the recently updated EULAR recommendations, is indicated for RP after failure of oral therapy. Read More

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April 2018
7 Reads

Diagnostic utility of automated indirect immunofluorescence compared to manual indirect immunofluorescence for anti-nuclear antibodies in patients with systemic rheumatic diseases: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Mar 27. Epub 2018 Mar 27.

Department of Laboratory Medicine, Cancer Research Institute, Kosin University College of Medicine, Gamcheon-ro 262, Seo-gu, Busan 49267, Republic of Korea. Electronic address:

Objective: This study aimed to review and compare the analytical and clinical performance of automated indirect immunofluorescence (AIIF) and manual indirect immunofluorescence (MIIF) as anti-nuclear antibody screening assays for patients with systemic rheumatic diseases (SRDs), such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).

Methods: A systematic literature search was performed in the Medline, Embase, Cochrane, Web of Science, and Scopus databases for studies published before August 2017. A bivariate random effects model was used to calculate the summary diagnostic values. Read More

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March 2018
3 Reads

The nomenclature of the basic disease elements of gout: A content analysis of contemporary medical journals.

Semin Arthritis Rheum 2018 Mar 28. Epub 2018 Mar 28.

Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland 1023, New Zealand. Electronic address:

Objectives: There is currently no standardised nomenclature for the basic disease elements of gout. This study aimed to identify these elements and examine how they are labelled in contemporary medical literature.

Methods: We analysed articles from the ten highest ranked general rheumatology journals, and five highest ranked general internal medicine journals (by Impact Factor, according to 2015 Thomson-Reuters Journal Citation Reports), published between 1 January 2012 and 31 January 2017. Read More

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March 2018
4 Reads

The effect of cigarette smoking on the clinical and serological phenotypes of polymyositis and dermatomyositis.

Semin Arthritis Rheum 2018 Feb 14. Epub 2018 Feb 14.

Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD.

Objective: Cigarette smoking is associated with immune-mediated disorders. We explored the contribution of smoking to polymyositis (PM) and dermatomyositis (DM) phenotypes and attempted to determine whether cigarette smoking effects differ by race and genotype.

Methods: Associations of tobacco smoking with disease features, autoantibodies, HLA types, and race were evaluated using multiple logistic regressions in 465 patients. Read More

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February 2018
4 Reads

Comment on: Inflammatory myopathy associated with anti-mitochondrial antibodies: A distinct phenotype with cardiac involvement.

Semin Arthritis Rheum 2018 Mar 28. Epub 2018 Mar 28.

Division of Rheumatology and Clinical Immunology, Laboratory of Autoimmunity and Metabolism, Humanitas Research Hospital, Rozzano, Milan, Italy; BIOMETRA Department, University of Milan, Italy. Electronic address:

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March 2018
3 Reads

Patient acceptable symptom state and minimal clinically important difference for patient-reported outcomes in systemic sclerosis: A secondary analysis of a randomized controlled trial comparing personalized physical therapy to usual care.

Semin Arthritis Rheum 2018 Mar 27. Epub 2018 Mar 27.

AP-HP, Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Hôpitaux Universitaires Paris Centre-Groupe Hospitalier Cochin, Paris, France; Sorbonne Paris Cité, Université Paris Descartes, Faculté de Médecine, Paris, France; INSERM UMR 1124, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, Faculté des Sciences Fondamentales et Biomédicales, Centre Universitaire des Saints-Pères, Paris, France. Electronic address:

Background: To estimate patient acceptable symptom state (PASS) and minimal clinically important difference (MCID) for patient-reported outcomes in systemic sclerosis (SSc).

Methods: We conducted a secondary analysis of the SCLEREDUC trial, a 12-month randomized controlled trial comparing the efficacy of physical therapy to usual care in 220 SSc patients followed-up from September 2005 to October 2010. Self-rated state and change in patient health at 12 months were assessed by using 2 external anchors extracted from the Medical Outcomes Study 36-Item Short-Form. Read More

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March 2018
3 Reads

Baseline patient reported outcomes are more consistent predictors of long-term functional disability than laboratory, imaging or joint count data in patients with early inflammatory arthritis: A systematic review.

Semin Arthritis Rheum 2018 Mar 15. Epub 2018 Mar 15.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, UK. Electronic address:

Objective: To assess baseline predictors of long-term functional disability in patients with inflammatory arthritis (IA).

Methods: We conducted a systematic review of the literature from 1990 to 2017 using MEDLINE and EMBASE. Studies were included if (i) they were prospective observational studies, (ii) all patients had IA with symptom duration ≤2 years at baseline, (iii) follow-up was at least 5 years, and (iv) baseline predictors of HAQ score at long-term follow-up (i. Read More

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March 2018
4 Reads

No difference in cardiovascular risk of tocilizumab versus abatacept for rheumatoid arthritis: A multi-database cohort study.

Semin Arthritis Rheum 2018 Mar 22. Epub 2018 Mar 22.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120.

Objectives: While tocilizumab may increase serum lipid levels, recent studies do not suggest a link between tocilizumab use and clinical cardiovascular risk in patients with rheumatoid arthritis (RA).

Methods: To compare cardiovascular safety of tocilizumab with abatacept, we conducted a cohort study using data from Medicare (2010-2013), IMS PharMetrics (2011-2014) and MarketScan (2011-6/2015). RA patients aged ≥18 years who newly started tocilizumab or abatacept entered the cohort on the day of their first use of tocilizumab or abatacept after a continuous enrollment period for ≥365 days. Read More

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March 2018
3 Reads

Cardiovascular risk factors predicting cardiac events are different in patients with rheumatoid arthritis, psoriatic arthritis, and psoriasis.

Semin Arthritis Rheum 2018 Mar 17. Epub 2018 Mar 17.

Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff University, Cardiff, United Kingdom.

Objectives: Increased cardiovascular risk in rheumatoid arthritis (RA) is well established. Examining traditional cardiovascular risk factors alone underestimates cardiovascular risk in RA. Systematic inflammation, measured by erythrocyte sedimentation rate or C-reactive protein is also a major risk factor. Read More

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March 2018
5 Reads

Comparing ultraviolet light A photo(chemo)therapy with Methotrexate protocol in childhood localized scleroderma: Evidence from systematic review and meta-analysis approach.

Semin Arthritis Rheum 2018 Mar 14. Epub 2018 Mar 14.

Department of Neurofarba, University of Studies of Florence, Italy; Paediatric Rheumatology, Hospital Anna Meyer, Florence, Italy.

Objective: Localized scleroderma is a skin fibrosing disorder that, if untreated, may result in severe disability. The purpose of this systematic review is to compare the present evidence concerning the effectiveness of Methotrexate versus phototherapy, alone or associated with Psoralen, in childhood localized scleroderma.

Method: A systematic search between January 1996 and May 2017 was performed to identify studies investigating the efficacy of Methotrexate (MTX) or phototherapy (UVA) for treating localized scleroderma with onset ≤18 years. Read More

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March 2018
4 Reads

Serum Bisphenol A is an independent risk factor of hyperuricemia: A 6-year prospective study.

Semin Arthritis Rheum 2018 Mar 17. Epub 2018 Mar 17.

Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Objective: This study aims to evaluate whether serum Bisphenol A (BPA) is a risk factor for hyperuricemia.

Methods: In this prospective study, a total of 482 participants without hyperuricemia were enrolled at baseline and followed up for 6 years. Clinical characteristics were recorded, and serum levels of uric acid and BPA were measured. Read More

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March 2018
3 Reads

Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Mar 10. Epub 2018 Mar 10.

Center for Complementary and Integrative Medicine, Division of Rheumatology, Tufts Medical Center, 800 Washington St., #406, Boston, MA 02111.

Purpose: The unfavorable safety profiles of commonly prescribed knee osteoarthritis (OA) treatments have led clinicians and patients to seek safer alternatives. Research has suggested that curcuminoid and boswellia formulations could moderate key inflammatory pathways that are associated with worsening symptoms and disease progression. We conducted a systematic review and meta-analysis to assess the efficacy and safety of these treatments vs. Read More

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March 2018
3 Reads

Diagnostic value of screening enzyme immunoassays compared to indirect immunofluorescence for anti-nuclear antibodies in patients with systemic rheumatic diseases: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Mar 30. Epub 2018 Mar 30.

Department of Preventive Medicine, College of Medicine, Korea University, Anam-ro 145, Seong Buk Gu, Seoul 02841, Republic of Korea. Electronic address:

Objective: This study aimed to review and compare the diagnostic accuracy of the screening enzyme immunoassay (SEIA) and indirect immunofluorescence (IIF) as anti-nuclear antibody (ANA) screening assays for patients with systemic rheumatic diseases (SRDs), including systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and systemic sclerosis (SSc).

Methods: A systematic literature search was conducted in the Medline, Embase, Cochrane, Web of Science, and Scopus databases for articles published before August 2017. A bivariate random effects model was used to calculate pooled diagnostic values. Read More

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March 2018
5 Reads

Predictive value of early structural changes on radiographs and MRI for incident clinical and radiographic knee osteoarthritis in overweight and obese women.

Semin Arthritis Rheum 2018 Mar 27. Epub 2018 Mar 27.

Erasmus MC University Medical Center Rotterdam, Department of General Practice, PO box 2040, 3000 CA Rotterdam, The Netherlands; Erasmus MC University Medical Center Rotterdam, Department of Orthopedics, PO box 2040, 3000 CA Rotterdam, The Netherlands; D-BOARD Consortium, an European Committee FP7 Project.

Objective: To determine the predictive value of tibiofemoral (TF), patellofemoral (PF) MRI osteoarthritis (OA), and Kellgren and Lawrence grade 1 (KLG1) for the incidence of knee OA (clinical and/or radiological signs) at 2.5 and 6.5 years follow-up in a high-risk cohort. Read More

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March 2018
4 Reads

Does nailfold capillaroscopy help predict future outcomes in systemic sclerosis? A systematic literature review.

Semin Arthritis Rheum 2018 Feb 14. Epub 2018 Feb 14.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK; Royal National Hospital for Rheumatic Diseases (at Royal United Hospitals), Upper Borough Walls, Bath, Bath BA1 1RL, UK. Electronic address:

Background: Nailfold capillaroscopy (NC) is an important diagnostic tool in systemic sclerosis (SSc). Confirmation of NC as a prognostic factor could facilitate earlier intervention and slow disease progression in SSc. We undertook a systematic literature review to evaluate the prognostic value of NC in predicting SSc disease progression. Read More

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February 2018
4 Reads

Phenotypic characterization of patients with rheumatologic manifestations of common variable immunodeficiency.

Semin Arthritis Rheum 2018 Feb 23. Epub 2018 Feb 23.

Divisions of Rheumatology and Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD.

Patients with common variable immunodeficiency (CVID) have a higher incidence of rheumatologic disorders. To delineate this clinical association, we investigated the phenotypic features of patients with CVID affected by these conditions.

Methods: We conducted a retrospective analysis of 870 pediatric and adult patients with CVID included in the United States Immunodeficiency Network (USIDNET) registry. Read More

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February 2018
4 Reads

Predictors of the effect of bariatric surgery on knee osteoarthritis pain.

Semin Arthritis Rheum 2018 Feb 8. Epub 2018 Feb 8.

Division of Rheumatology, Department of Medicine, NYU Langone Medical Center, 333 East 38th St., New York, NY 10016. Electronic address:

Introduction: Bariatric surgery reduces obesity and knee osteoarthritis (OA) pain, but some patients improve more than others. We aimed to identify characteristics that predict this knee pain improvement.

Methods: We reviewed NYU Langone Health bariatrics records (2002-2015) and called eligible patients reporting pre-operative knee pain. Read More

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February 2018
4 Reads

Clinical value of autoantibodies for lupus myelitis and its subtypes: A systematic review.

Semin Arthritis Rheum 2018 Feb 14. Epub 2018 Feb 14.

Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.

Objective: We conducted a systematic review to investigate the clinical value of clinical characteristics and autoantibodies, especially lupus-specific antibodies, for lupus myelitis and its subtypes.

Methods: We searched PubMed, EMBASE, and ICHUSHI without language restrictions for case reports or series of lupus myelitis. We focused on cases reported since 1997, when the revised classification criteria for systemic lupus erythematosus were published. Read More

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February 2018
4 Reads

Clinical presentation of immune checkpoint inhibitor-induced inflammatory arthritis differs by immunotherapy regimen.

Semin Arthritis Rheum 2018 Mar 21. Epub 2018 Mar 21.

Johns Hopkins University, Division of Rheumatology, 5501 Hopkins Bayview Circle, Suite 1.B.1, Baltimore, MD.

Introduction: Immune checkpoint inhibitors (ICIs) are a class of cancer immunotherapy, increasingly utilized to treat malignancies. Inflammatory arthritis (IA) is a potential consequence of ICI use, but there is limited information to guide evaluation and management of this immune-related adverse event (irAE). This study aimed to characterize clinical phenotypes, IA treatment and response in the largest cohort of patients with ICI-induced IA reported to date. Read More

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March 2018
6 Reads

Dactylitis: A hallmark of psoriatic arthritis.

Semin Arthritis Rheum 2018 Feb 14. Epub 2018 Feb 14.

Intermountain Healthcare, Salt Lake City, UT.

Objective: Dactylitis-long considered a hallmark clinical feature of psoriatic arthritis (PsA)-occurs in 16-49% of patients with PsA. In this review, we discuss the pathology of dactylitis in PsA and clinical and imaging tools used to diagnose and monitor dactylitis.

Methods: PubMed literature searches were conducted using the terms psoriatic arthritis, dactylitis, pathology, imaging, ultrasound, magnetic resonance imaging, clinical, and indices. Read More

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February 2018
4 Reads

Measurement properties of patient reported outcome measures for spondyloarthritis: A systematic review.

Semin Arthritis Rheum 2018 Mar 21. Epub 2018 Mar 21.

Programme in Health Services and Systems Research, Duke-NUS Medical School, 8 College Rd, Singapore 169857, Singapore.

Objectives: This systematic review aimed to identify studies investigating measurement properties of patient reported outcome measures (PROMs) for spondyloarthritis (SpA), and to evaluate their methodological quality and level of evidence relating to the measurement properties of PROMs.

Methods: This systematic review was guided by the preferred reporting items for systematic review and meta-analysis (PRISMA). Articles published before 30 June 2017 were retrieved from PubMed, Embase, and PsychINFO (Ovid). Read More

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March 2018
5 Reads

What is the prevalence of cognitive impairment in lupus and which instruments are used to measure it? A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Feb 21. Epub 2018 Feb 21.

Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto Lupus Clinic, EW, 1-412, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada. Electronic address:

Objectives: To systematically review the literature on the prevalence of Cognitive Dysfunction (CD) in SLE patients in studies that used a specified neuropsychological instrument.

Methods: This review was prepared with a protocol following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Protocols statement. Literature search in Ovid Medline, Embase, and Psyc INFO for articles on CD in adult SLE patients was conducted. Read More

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February 2018
8 Reads

Serum urate as surrogate endpoint for flares in people with gout: A systematic review and meta-regression analysis.

Semin Arthritis Rheum 2018 Feb 21. Epub 2018 Feb 21.

Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

Objectives: The primary efficacy outcome in trials of urate lowering therapy (ULT) for gout is serum urate (SU). The aim of this study was to examine the strength of the relationship between SU and patient-important outcomes to determine whether SU is an adequate surrogate endpoint for clinical trials.

Methods: Multiple databases through October 2017 were searched. Read More

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February 2018
6 Reads

Considerations for the definition of remission criteria in psoriatic arthritis.

Semin Arthritis Rheum 2018 Jun 31;47(6):786-796. Epub 2017 Oct 31.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

Objectives: Psoriatic arthritis (PsA) is an autoimmune disease that can cause progressive structural damage of the joints and irreversible disability. The potentially achievable results of biologic therapy for PsA has led to the view that disease remission should be the goal of treatment. However, the heterogeneity of disease manifestations and need for validated outcome measures makes defining remission in PsA challenging. Read More

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June 2018
3 Reads

Predicting eventual development of lupus nephritis at the time of diagnosis of systemic lupus erythematosus.

Semin Arthritis Rheum 2018 Feb 23. Epub 2018 Feb 23.

Division of Rheumatology, Department of Medicine, University of Ulsan, College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea. Electronic address:

Objectives: To investigate factors predictive of future lupus nephritis development when systemic lupus erythematosus (SLE) is diagnosed.

Methods: Patients with newly diagnosed SLE without renal manifestations were followed for development of lupus nephritis, comparing findings at baseline between those who did or did not develop nephritis. Albumin-to-globulin ratio (AGR) was calculated as albumin/(total protein-albumin). Read More

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February 2018
11 Reads

Low disease activity-irrespective of serologic status at baseline-associated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: A real-life observational study.

Semin Arthritis Rheum 2018 Feb 23. Epub 2018 Feb 23.

Rheumatology and Clinical Immunology, 4th Department of Medicine, "Attikon" University Hospital, Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece-Medical School University of Cyprus, Nikosia, Cyprus.

Background: Low disease activity is a validated target of current systemic lupus erythematosus (SLE) therapy. The aim of this study was to assess the ability of belimumab to achieve low disease activity states in real-life settings.

Methods: Multicentre prospective observational study of consecutive SLE patients receiving belimumab for at least 3 months, due to active disease refractory to at least one conventional immunosuppressant. Read More

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February 2018
7 Reads

Pulmonary manifestations in late versus early systemic lupus erythematosus: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Jan 31. Epub 2018 Jan 31.

Department of Medicine, Rheumatology Division, University of Wisconsin School of Medicine and Public Health, 1685 Highland Ave, Rm 4132, Madison, WI. Electronic address:

Objectives: Phenotypes differ between late- and early-onset systemic lupus erythematosus (SLE). Prior studies suggested that there may be more pulmonary disease among late-onset patients. Our objective was to perform a systematic review and meta-analysis to evaluate the differences in pulmonary manifestations in late- versus early-onset SLE. Read More

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January 2018
4 Reads

Is abnormal glucose tolerance or diabetes a risk factor for knee, hip, or hand osteoarthritis? A systematic review.

Semin Arthritis Rheum 2018 Feb 21. Epub 2018 Feb 21.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Alfred Hospital, Monash University, Melbourne Vic 3004, Australia. Electronic address:

Objective: Diabetes (DM) and osteoarthritis (OA) are two common co-existing chronic conditions. However, whether this is due to shared risk factors or may differ between joints is unclear. We performed a systematic review to determine whether abnormal glucose metabolism is a risk factor for knee, hip and hand OA, separately, independent of age and obesity. Read More

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February 2018
3 Reads

Predictors of hypogammaglobulinemia during rituximab maintenance therapy in rheumatoid arthritis: A 12-year longitudinal multi-center study.

Semin Arthritis Rheum 2018 Feb 21. Epub 2018 Feb 21.

Université Paris Descartes, Sorbonne Paris Cité, Service de Rhumatologie A, Hôpital Cochin, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France. Electronic address:

Objective: Rituximab (RTX) is an anti-CD20 monoclonal antibody that selectively depletes B-cell population. Thus, it presents a potential risk for the development of hypogammaglobulinemia and related infectious events. Our aim was to identify predictors of hypogammaglobulinemia in RA patients long-term treated with RTX. Read More

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February 2018
5 Reads