142,544 results match your criteria Arthritis Rheumatoid


Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb.

J Ethnopharmacol 2019 Apr 21:111902. Epub 2019 Apr 21.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China. Electronic address:

Ethnopharmacological Relevance: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by failure of spontaneous resolution of inflammation. The stem of Kadsura heteroclite (KHS) is a well-known anti-arthritic Tujia ethnomedicinal plant, which named Xuetong in folk, has long been used for the prevention and treatment of rheumatic and arthritic diseases.

Aim Of The Study: The analgesic and anti-inflammatory effects and the potential mechanisms behind such effects of KHS would be investigated by using different animal models. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111902DOI Listing

Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients.

Ann Noninvasive Electrocardiol 2019 Apr 24:e12651. Epub 2019 Apr 24.

Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China.

Background: Osteogenic circulating endothelial progenitor cells (EPC) play a pathogenic role in cardiovascular system degeneration through promulgating vasculature calcification, but its role in conduction disorders as part of the cardiovascular degenerative continuum remained unknown.

Aim: To investigate the role of osteocalcin (OCN)-expressing circulating EPCs in cardiac conduction disorders in the unique clinical sample of rheumatoid arthritis (RA) susceptible to both abnormal bone metabolism and cardiac conduction disorders.

Methods: We performed flow cytometry studies in 134 consecutive asymptomatic patients with rheumatoid arthritis to derive osteogenic circulating OCN-positive (OCN+) CD34+KDR+ vs. Read More

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http://dx.doi.org/10.1111/anec.12651DOI Listing

Automatic localization of anatomical regions in medical ultrasound images of rheumatoid arthritis using deep learning.

Proc Inst Mech Eng H 2019 Apr 24:954411919845747. Epub 2019 Apr 24.

3 Department of Biomedical Engineering, Vels Institute of Science, Technology and Advanced Studies, Chennai, India.

The pace of population aging is growing faster worldwide. The quality of life of the aging population is mostly affected by rheumatic diseases. With the increasing rate of rheumatoid arthritis in the aging population, technological advances in the field of automatic image processing and analysis have paved way for automatic detection and diagnosis of arthritis based on how the grade of the synovial region is designed. Read More

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http://dx.doi.org/10.1177/0954411919845747DOI Listing

Capillaroscopic features of microangiopathy in rheumatoid arthritis patients with peripheral vascular syndrome.

Clin Rheumatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Giessen, Germany.

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http://dx.doi.org/10.1007/s10067-019-04561-xDOI Listing

Rituximab in connective tissue disease-associated interstitial lung disease.

Clin Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

Rheumatology Department, Hospital Garcia de Orta EPE, Avenida Torrado da Silva, 2805-267, Almada, Portugal.

Introduction/objectives: To evaluate rituximab (RTX) effectiveness and safety in patients with interstitial lung disease (ILD) related to connective tissue diseases (CTD).

Methods: Retrospective multicenter cohort study, including patients with CTD-ILD, followed in six Portuguese rheumatology departments until November 2018. ILD diagnosis was based on high-resolution CT (HRCT) and/or lung biopsy. Read More

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http://link.springer.com/10.1007/s10067-019-04557-7
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http://dx.doi.org/10.1007/s10067-019-04557-7DOI Listing
April 2019
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Changing rate of serious infections in biologic-exposed rheumatoid arthritis patients. Data from South American registries BIOBADABRASIL and BIOBADASAR.

Clin Rheumatol 2019 Apr 17. Epub 2019 Apr 17.

Santiago University Clinical Hospital Institute of Medical Research, Santiago de Compostela, Spain.

Objective: Most reports on serious infections (SI) in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) are from the USA and Western Europe. Data from other regions are largely missing. We report data from South American countries with different backgrounds and health-care systems but similar registries. Read More

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http://dx.doi.org/10.1007/s10067-019-04516-2DOI Listing

Dopaminergic Agents in Rheumatoid Arthritis.

Authors:
Silvia Capellino

J Neuroimmune Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Junior Group Neuroimmunology, Department of Immunology, IfADo - Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.

Clinical evidences suggest a causal relationship between rheumatoid arthritis (RA) and the dopaminergic system, and several studies described an alteration of the disease in patients treated with dopaminergic agents. Despite these interesting results, potential direct effects of dopamine on RA have not been intensively considered until the last decade. Recent studies confirm a direct effect of dopamine on the systemic immune response as well as on bone remodeling and on joint inflammation, both in humans and in different animal models of arthritis. Read More

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http://dx.doi.org/10.1007/s11481-019-09850-5DOI Listing

Effectiveness of Remission Induction Strategies for Early Rheumatoid Arthritis: a Systematic Literature Review.

Curr Rheumatol Rep 2019 Apr 23;21(6):24. Epub 2019 Apr 23.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, G02.228, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.

Purpose Of Review: To review the effectiveness of remission induction strategies compared to single csDMARD-initiating strategies according to current guidelines in early RA.

Recent Findings: Twenty-nine studies, heterogeneous on, e.g. Read More

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http://dx.doi.org/10.1007/s11926-019-0821-1DOI Listing

[Depressive symptoms in early rheumatoid arthritis : Within the rheumatism network ADAPTHERA].

Z Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

ACURA Rheumazentrum Rheinland-Pfalz, Kaiser-Wilhelm-Straße 9-11, 55543, Bad Kreuznach, Deutschland.

Background And Objective: For patients with established rheumatoid arthritis and also early arthritis an increased prevalence of depression has been described. For a better understanding of depression in early arthritis patients, depression prevalences of a German early arthritis cohort were examined, with a focus on disease activity, anti-CCP status, disease duration and functional capacity over a period of 2 years.

Material And Methods: The evaluation was based on the early arthritis cohort ADAPTHERA from Rhineland-Palatinate. Read More

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http://dx.doi.org/10.1007/s00393-019-0596-9DOI Listing

Comparative Evaluation of Ga-Citrate PET/CT and F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats.

Contrast Media Mol Imaging 2019 19;2019:2353658. Epub 2019 Mar 19.

Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. Read More

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http://dx.doi.org/10.1155/2019/2353658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444231PMC

Measurement of Disease Activity in Ecuadorian Patients with Rheumatoid Arthritis: Does RAPID3 Correlate with Traditional Indexes?

ScientificWorldJournal 2019 20;2019:6940401. Epub 2019 Mar 20.

Department of Rheumatology, Unidad de Enfermedades Reumáticas y Autoinmunes [UNERA] (Unit of Rheumatology and Autoimmune Diseases), Guayaquil, Ecuador.

Objective: The aim of this study is to demonstrate if routine assessment of patient index data 3 has a correlation with disease's activity as much as disease activity score 28, clinical disease activity index, and simplified disease activity index in Ecuadorian patients with rheumatoid arthritis seen in Unidad de Enfermedades Reumáticas y Autoinmunes [UNERA] from December 2016 to December 2017.

Methods: This is a retrospective study in 200 patients that fulfill the American College of Rheumatology 2010 criteria for diagnosis of rheumatoid arthritis. The patients were evaluated from December 2016 to December 2017. Read More

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http://dx.doi.org/10.1155/2019/6940401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446084PMC

Nanomedicines for improved targetability to inflamed synovium for treatment of rheumatoid arthritis: Multi-functionalization as an emerging strategy to optimize therapeutic efficacy.

J Control Release 2019 Apr 20. Epub 2019 Apr 20.

Department of Pharmaceutics & Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address:

Owing to its intricate autoimmune pathophysiology and significant risks of progression to other rheumatic co-morbidities (i.e., osteoporosis and osteoarthritis), a plausible therapeutic regimen is mandatory for early-stage management of rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.027DOI Listing

Recommended Reading from the Massachusetts General Hospital/ Beth Israel Deaconess Medical Center/ Harvard Pulmonary and Critical Care Medicine Fellows.

Am J Respir Crit Care Med 2019 Apr 23. Epub 2019 Apr 23.

Beth Israel Deaconess Medical Center, 1859, Pulmonary and Critical Care Medicine, Boston, Massachusetts, United States ;

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http://dx.doi.org/10.1164/rccm.201902-0471RRDOI Listing

Could Polyphenols Help in the Control of Rheumatoid Arthritis?

Molecules 2019 Apr 22;24(8). Epub 2019 Apr 22.

College of Korean Medicine, Kyung Hee University, Seoul, Seoul 02453, Korea.

Rheumatoid arthritis (RA) is a chronic, systemic, joint-invading, autoimmune inflammatory disease, which causes joint cartilage breakdown and bone damage, resulting in functional impairment and deformation of the joints. The percentage of RA patients has been rising and RA represents a substantial burden for patients around the world. Despite the development of many RA therapies, because of the side effects and low effectiveness of conventional drugs, patients still need and researchers are seeking new therapeutic alternatives. Read More

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http://dx.doi.org/10.3390/molecules24081589DOI Listing

Discovery and Lead-optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

J Med Chem 2019 Apr 23. Epub 2019 Apr 23.

RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently RIP1 kinase inhibitors have advanced into early clinical trials for evaluation in inflammatory diseases such as psoriasis, rheumatoid arthritis and ulcerative colitis, and neuro-logical diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. In this paper we report on the design of potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitors starting from a high-throughput screen and the lead-optimization of this series from a lead with minimal rat oral exposure to the identification of dihydropyrazole 77 with good pharmacokinetic profiles in multiple species. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00318DOI Listing

Serum drug concentrations to optimize switching from adalimumab to etanercept in rheumatoid arthritis.

Scand J Rheumatol 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Rheumatology , Amsterdam Rheumatology and Immunology Center , Reade , Amsterdam , The Netherlands.

Objectives: Inadequate response to adalimumab can be caused by insufficient blockade of the target tumour necrosis factor (TNF) at low serum concentrations. In such cases, patients may respond to another TNF inhibitor. We investigated whether the serum adalimumab concentration is related to the efficacy of a second TNF inhibitor, etanercept, in rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1080/03009742.2019.1577915DOI Listing

Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice.

Int J Rheum Dis 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.

Aim: To assess predictors of alanine aminotransferase (ALT) elevation in methotrexate (MTX) treated rheumatoid arthritis (RA) patients, and to describe the monitoring of liver enzymes, including handling and outcome of elevated ALT.

Methods: All RA patients starting MTX in January, 2005 to April, 2013 at a rheumatology clinic, (Uppsala University Hospital, Sweden) were identified from electronic medical records. Clinical and laboratory data were obtained from medical records, supplemented by telephone interviews. Read More

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http://dx.doi.org/10.1111/1756-185X.13576DOI Listing

RGS1 silencing inhibits the inflammatory response and angiogenesis in rheumatoid arthritis rats through the inactivation of Toll-like receptor signaling pathway.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.

Emerging evidence shows that rheumatoid arthritis (RA) progression can be induced by the activation of Toll-like receptor (TLR) signaling pathway. Regulator of G-protein signaling 1 (RGS1) is observed to be a candidate biomarker for arthritis. Accordingly, the present study aims to determine the potential effects of RGS1 mediating TLR on RA. Read More

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http://dx.doi.org/10.1002/jcp.28645DOI Listing

CCL5 and related genes might be the potential diagnostic biomarkers for the therapeutic strategies of rheumatoid arthritis.

Clin Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

The Department of Internal Medicine of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Objective: Rheumatoid arthritis (RA) is a common disease of rheumatic diseases. The aim of this study was to identify gene signatures in RA and uncover their potential mechanisms.

Method: Gene expression profiles of GSE1919, GSE55235, GSE55457, and GSE77928 were downloaded from GEO database. Read More

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http://link.springer.com/10.1007/s10067-019-04533-1
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http://dx.doi.org/10.1007/s10067-019-04533-1DOI Listing
April 2019
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Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development.

Biomed Res Int 2019 18;2019:8326246. Epub 2019 Mar 18.

Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan.

Vitamin D is an anti-inflammatory molecule and has a role in prevention of arthritis development. Biologically active form 1, 25(OH)D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. VDR gene polymorphism leads to dysfunctioning of 1, 25(OH)D ultimately disease onset. Read More

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https://www.hindawi.com/journals/bmri/2019/8326246/
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http://dx.doi.org/10.1155/2019/8326246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442488PMC
March 2019
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Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics.

Evid Based Complement Alternat Med 2019 18;2019:9864841. Epub 2019 Mar 18.

School of Pharmacy, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Combination of Aconiti Lateralis Radix Praeparata (FZ) and Paeoniae Radix Alba (BS) shows a significant effect in rheumatoid arthritis (RA). This study aimed to investigate the efficacy enhancing and toxicity reducing mechanism of combination of them in adjuvant-induced arthritis (AIA) rats by metabolomics. Rats were randomly divided into seven groups, including A (healthy control), B (model control), C1 (therapy group), C2 (efficacy enhancing group), D1 (toxicity group), and D2 (toxicity reducing group), and dexamethasone group was used as positive control. Read More

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http://dx.doi.org/10.1155/2019/9864841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442482PMC

Discrete Papular Lichen Myxedematosus and Scleromyxedema with Hypothyroidism: A Report of Two Cases.

Case Rep Dermatol 2019 Jan-Apr;11(1):64-70. Epub 2019 Mar 19.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Scleromyxedema and lichen myxedematosus (LM) are rare disorders that fall along the spectrum of primary cutaneous mucinoses. Scleromyxedema is a systemic form that classically presents with generalized waxy papules, sclerodermoid eruption, and monoclonal gammopathy; LM is a localized form limited to the skin that classically presents with white, firm, waxy papules and lacks monoclonal gammopathy. According to diagnostic criteria established in 2001, the diagnosis of both conditions requires absence of thyroid disease. Read More

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http://dx.doi.org/10.1159/000498881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465707PMC

Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1628-1634

a Department of Rheumatology , Dongfang Hospital of Beijing University of Chinese Medicine , Beijing , China.

Chronic inflammation in fibroblast-like synoviocytes (FLSs) induced by pro-inflammatory cytokines such as TNF-α plays a key role in the pathogenesis of rheumatoid arthritis (RA). The neurokinin-1 receptor (NK-1R) is one of the G protein-coupled receptors (GPCRs) mediating the intracellular signalling of substance P (SP). However, the possible implications of NK-1R in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and the pathogenesis of RA have not yet been reported. Read More

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http://dx.doi.org/10.1080/21691401.2019.1573177DOI Listing
December 2019

The Antioxidant from Ethanolic Extract of Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect.

Int J Mol Sci 2019 Apr 19;20(8). Epub 2019 Apr 19.

Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.

Tratt is a Chinese herbal remedy that is used in the treatment of diarrhea, burns, rheumatoid arthritis, and hemorrhage. Despite its use in Asian folk medicine, there are limited reports on the biological activity of fruits. This study focused on the investigation of the antitumor effect of the antioxidative ethanolic extract of fruits (RCE) along with its underlying mechanism of action. Read More

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http://dx.doi.org/10.3390/ijms20081935DOI Listing

Attitudes towards Oral Health in Patients with Rheumatoid Arthritis: A Qualitative Study Nested within a Randomized Controlled Trial.

JDR Clin Trans Res 2019 Apr 22:2380084419833694. Epub 2019 Apr 22.

1 Periodontal Research Group, School of Dentistry, Institute of Clinical Sciences, University of Birmingham, and Birmingham Dental Hospital (Birmingham Community Healthcare NHS Foundation Trust), Edgbaston, Birmingham, UK.

Introduction: Patients with rheumatoid arthritis (RA) present a higher incidence and severity of periodontitis than the general population. Our study, Outcomes of Periodontal Treatment in Patients with Rheumatoid Arthritis (OPERA), was a randomized waiting-list controlled trial using mixed methods. Patients randomized to the intervention arm received intensive periodontal treatment, and those in the control arm received the same treatment with a 6-mo delay. Read More

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http://dx.doi.org/10.1177/2380084419833694DOI Listing

Association Between , Its Polymorphism and Ischemia-Modified Albumin in Patients with Rheumatoid Arthritis.

J Interferon Cytokine Res 2019 Apr 22. Epub 2019 Apr 22.

7 Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Faiyum, Egypt.

Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease. We aimed to measure the level of miR-155 and its genetic variant rs767649 in patients with RA and to evaluate their relationship with ischemia-modified albumin (IMA). The study was performed on 79 patients with RA (group I) and 78 healthy control participants (group II). Read More

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http://dx.doi.org/10.1089/jir.2019.0001DOI Listing

Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through AKT/FOXO1 signaling.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Dermatology department, Shaanxi hospital of traditional Chinese medicine, Xi'an, China.

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one (eriodictyol), a flavonoid compound, was proved to possess anti-inflammatory, antioxidative, and antiarthritis activities. However, the effects of eriodictyol on the rheumatoid proliferation, apoptosis, and inflammatory response of arthritis fibroblast-like synoviocytes (RA-FLS) remain unclear. Thus, the objective of this study was to examine the effects of eriodictyol on RA-FLS survival, apoptosis, and inflammatory response, and further explore the potential underlying mechanisms. Read More

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http://dx.doi.org/10.1002/jcb.28724DOI Listing

Development and validation of a sensitive UHPLC-MS/MS-based method for the analysis of folylpolyglutamate synthetase enzymatic activity in peripheral blood mononuclear cells: application in rheumatoid arthritis and leukemia patients.

Ther Drug Monit 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Chemistry, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands.

Background: Folylpolyglutamate synthetase (FPGS) is a crucial enzyme in both cellular folate homeostasis and the intracellular retention of folate analogue drugs like methotrexate (MTX), which is commonly used for the treatment of (pediatric) leukemia and the anchor drug in rheumatoid arthritis (RA) treatment. To date, assessment of FPGS catalytic activity relies on assays utilizing radioactive substrates which are labor-intensive and require relatively large numbers of cells. Here, we describe a non-radioactive, UHPLC-MS/MS-based method allowing sensitive and accurate measurements of FPGS activity in low cell numbers (i. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000638DOI Listing

Patient- and Rheumatologist- Perspectives Regarding Challenges to Achieving Optimal Disease Control in Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL.

Objective: To identify and prioritize patient- and rheumatologist-perceived barriers to achieving disease control.

Methods: RA patients and rheumatologists from the Consortium of Rheumatology Researchers of North America (Corrona) registry were invited by email to participate in nominal groups (NGs). Two separate lists of barriers were created, one from RA-patient-only NGs and other from rheumatologist-only NGs, and barriers were sorted into themes. Read More

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http://dx.doi.org/10.1002/acr.23907DOI Listing
April 2019
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Predictors of fragility fracture and low bone mineral density in patients with a history of parental fracture.

Osteoporos Sarcopenia 2019 Mar 15;5(1):6-10. Epub 2019 Mar 15.

University Hospitals of Morecambe Bay NHS Foundation Trust, Royal Lancaster Infirmary, Rheumatology, Ashton Road, Lancaster, Lancashire, UK.

Objectives: Bone mineral density (BMD) and fragility fracture (FF) have high heritability, but few data exist on impact of other factors on families with fracture history. We aimed to evaluate predictors of FF and low BMD, in patients with family history of FF.

Methods: This was a retrospective study on patients undergoing dual energy X-ray absorptiometry at a district general hospital (DGH), 2004-2016. Read More

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http://dx.doi.org/10.1016/j.afos.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452922PMC

Inflammatory variant of pachydermoperiostosis responding to methotrexate: a report of two cases.

Oxf Med Case Reports 2019 Apr 16;2019(4):omy128. Epub 2019 Apr 16.

Department of Rheumatology, National Center for Rheumatic Diseases(NCRD), Kathmandu 44600, Nepal.

Pachydermoperiostosis is a rare genetic disorder characterized by skin thickening, digital clubbing and periostitis. The pathogenesis is incompletely understood and there are no proven treatments for its manifestations. Although arthritis has been reported in 20-40% cases, most are non-inflammatory in nature and usually treated symptomatically with steroids or NSAIDs. Read More

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https://academic.oup.com/omcr/article/doi/10.1093/omcr/omy12
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http://dx.doi.org/10.1093/omcr/omy128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467096PMC
April 2019
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Full-Blown Rheumatoid Heart and Vessels Associated with Rheumatoid Arthritis.

Heart Views 2018 Jul-Sep;19(3):102-105

Division of Cardiology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.

We report the case of a 54-year-old female patient with a history of rheumatoid arthritis (RA) who presented with dyspnea on exertion. Her pulsation on both arms was weak. Magnetic resonance (MR) angiography revealed Takayasu's arteritis (TA) characterized by multiple stenosis involving innominate, left common carotid, and left subclavian arteries. Read More

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http://www.heartviews.org/text.asp?2018/19/3/102/254344
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http://dx.doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_145_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448469PMC
April 2019
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IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors.

Am J Hum Genet 2019 Apr 6. Epub 2019 Apr 6.

Center for Data Sciences, Harvard Medical School, Boston, MA 02115, USA; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. Electronic address:

Despite significant progress in annotating the genome with experimental methods, much of the regulatory noncoding genome remains poorly defined. Here we assert that regulatory elements may be characterized by leveraging local epigenomic signatures where specific transcription factors (TFs) are bound. To link these two features, we introduce IMPACT, a genome annotation strategy that identifies regulatory elements defined by cell-state-specific TF binding profiles, learned from 515 chromatin and sequence annotations. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.03.012DOI Listing

Corticosteroids and Methotrexate as Adjuvants to Costimulation Blockade in Nonhuman Primate Renal Transplantation.

Clin Transplant 2019 Apr 21:e13568. Epub 2019 Apr 21.

Emory Transplant Center, Emory University, Atlanta, GA.

Belatacept, the CD28-B7 costimulation pathway inhibitor, has been approved as a calcineurin inhibitor (CNI) alternative in kidney transplantation. Although costimulation blockade (CoB) allows for CNI avoidance, it is associated with increased rates of early rejection, prompting a search for agents to pair with belatacept. Methotrexate (MTX) is an antimetabolite that has been found to be complimentary with abatacept, a lower affinity CD28-B7-specific analogue of belatacept, in the treatment of rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1111/ctr.13568DOI Listing

Treatment of Type II Collagen-Induced Rat Rheumatoid Arthritis Model by Interleukin 10 (IL10)-Mesenchymal Stem Cells (BMSCs).

Med Sci Monit 2019 Apr 21;25:2923-2934. Epub 2019 Apr 21.

Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND Rheumatoid arthritis model (CIA) rats were treated by tail vein injection of IL-10-modified bone marrow mesenchymal stem cells (BMSCs) to investigate its feasibility and intrinsic molecular mechanism. MATERIAL AND METHODS The CIA rat model was established by induction type II collagen, and IL-10-modified BMSCs was established by transfecting BMSCs with adenovirus. IL-10-modified BMSCs were used to treat the CIA rats. Read More

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http://dx.doi.org/10.12659/MSM.911184DOI Listing
April 2019
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Ethanolic extract of Kaempferia parviflora interrupts the mechanisms-associated rheumatoid arthritis in SW982 culture model via p38/STAT1 and STAT3 pathways.

Phytomedicine 2018 Nov 14;59:152755. Epub 2018 Nov 14.

Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Background: Kaempferia parviflora Wall. ex Baker (KP) has long been used in traditional medicine to treat various diseases because active compounds in rhizome extracts are important anti-inflammatory agents.

Purpose: This study aims to investigate the effects of an ethanolic extract of KP on the molecular mechanisms associated with rheumatoid arthritis (RA), which was induced by a combination of proinflammatory cytokines (IL-1β or TNF-α with IL-17A) in a human synovial sarcoma cell line (SW982) culture model. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.015DOI Listing
November 2018

Association Between Homocysteine Serum Level and Bone Mineral Density in Patients With Rheumatoid Arthritis.

J Clin Densitom 2019 Mar 28. Epub 2019 Mar 28.

Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Universitario San Cecilio, Granada, Spain.

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http://dx.doi.org/10.1016/j.jocd.2019.03.008DOI Listing

Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects.

Int Immunopharmacol 2019 Apr 17;72:292-300. Epub 2019 Apr 17.

Department of Immunology, Medical College of Nanchang University, Nanchang 330000, China. Electronic address:

Curcumin is a natural herbal product that has been popularly used to treat autoimmune diseases in China; however, its effects on rheumatoid arthritis and its mechanism are not clear. The main purposes of this study are to explore the therapeutic effects of curcumin on collagen-induced arthritis (CIA) rats and the pharmacological mechanism. In the present study, CIA rats were established by injecting bovine type II collagen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193079
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http://dx.doi.org/10.1016/j.intimp.2019.04.027DOI Listing
April 2019
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Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.

Matrix Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Virginia, Charlottesville, VA, USA. Electronic address:

The extracellular matrix (ECM) microenvironment is increasingly implicated in the instruction of pathologically relevant cell behaviors, from aberrant transdifferentation to invasion and beyond. Indeed, pathologic ECMs possess a panoply of alterations that provide deleterious instructions to resident cells. Here we demonstrate the precise manner in which the ECM protein fibronectin (FN) undergoes the posttranslational modification citrullination in response to peptidyl-arginine deiminase (PAD), an enzyme associated with innate immune cell activity and implicated in systemic ECM-centric diseases, like cancer, fibrosis and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1016/j.matbio.2019.04.002DOI Listing

Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan, China. Electronic address:

Rheumatoid arthritis fibroblast-like synoviocytes play an essential role in the occurrence and progression of rheumatoid arthritis. As the main pharmacologically active components of Aralia taibaiensis, total saponins, particularly triterpenoid saponins, have been shown to possess multiple pharmacological activities including relieving rheumatism. However, the effect of araloside A, a triterpenoid saponin extracted from the root bark of Aralia taibaiensis, on rheumatoid arthritis remains unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.025DOI Listing

Economic Evaluation of Sarilumab in the Treatment of Adult Patients with Moderately-to-Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs.

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

University of Nebraska Medical Center, Omaha, NE, USA.

Introduction: Assess the cost-effectiveness (US healthcare payer perspective) of sarilumab subcutaneous (SC) 200 mg + methotrexate versus conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) or targeted DMARD + methotrexate for moderate-to-severe rheumatoid arthritis (RA) in adults with inadequate response to methotrexate.

Methods: Microsimulation based on patient profiles from MOBILITY (NCT01061736) was conducted via a 6-month decision tree and lifetime Markov model with 6-monthly cycles. Treatment response at 6 months was informed by a network meta-analysis and based on American College of Rheumatology (ACR) response. Read More

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http://link.springer.com/10.1007/s12325-019-00946-1
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http://dx.doi.org/10.1007/s12325-019-00946-1DOI Listing
April 2019
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Oral health-related quality of life among individuals with rheumatoid arthritis.

Clin Rheumatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Oral Pathology and Surgery, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Objective: To evaluate the oral health-related quality of life (OHRQoL) of individuals with rheumatoid arthritis (RA) in comparison with individuals with no RA.

Method: A cross-sectional study was carried out with 112 individuals distributed into two groups. Group 1 (G1) consisted of 42 RA individuals and group 2 (G2) consisted of 70 individuals without RA. Read More

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http://link.springer.com/10.1007/s10067-019-04555-9
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http://dx.doi.org/10.1007/s10067-019-04555-9DOI Listing
April 2019
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A constitutional activating MET mutation makes the genetic link between malignancies and chronic inflammatory diseases.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Inserm U1165, University Paris 7.

Purpose: The genesis of all cancers results from an accumulation of mutations, constitutional and/or acquired when induced by external mutagenic factors. High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic changes.

Experimental Design: Here, we proposed an innovative individual approach by studying tissue samples from a young woman with an unusual association of breast cancer, polycythemia vera and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3261DOI Listing

Factors Associated With Bone Density Monitoring While on Antiosteoporosis Treatment in Routine Clinical Practice: A Registry-Based Cohort Study.

J Clin Densitom 2019 Mar 21. Epub 2019 Mar 21.

Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

The role for bone mineral density (BMD) monitoring while on antiosteoporosis therapy remains controversial. The current study used population-based registries to identify factors associated with BMD monitoring in women within 5 yr of receiving antiosteoporosis treatment vs treatment without monitoring in routine clinical practice. The analytical dataset consisted of women age 40 yr and older at baseline receiving antiosteoporosis therapy: 6877 with BMD monitoring (mean interval 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10946950193003
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http://dx.doi.org/10.1016/j.jocd.2019.03.006DOI Listing
March 2019
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Shedding New Light on The Role of ανβ3 and α5β1 Integrins in Rheumatoid Arthritis.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

The Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu Province, China Pharmaceutical University, Nanjing 210009, China.

ανβ3 and α5β1 are essential glycoproteins involved in the pathogenesis of rheumatoid arthritis (RA). Understanding of the role these integrins play in disease have been analyzed via description of cells-expressing ανβ3 and α5β1 and their mediators to trigger inflammation. ανβ3 and α5β1 facilitate cells-ECM and cell-cell communication, producing pro-inflammatory factors. Read More

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https://www.mdpi.com/1420-3049/24/8/1537
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http://dx.doi.org/10.3390/molecules24081537DOI Listing
April 2019
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Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Gaetano Pieraccini 6, 50139 Florence, Italy.

To study new target-oriented molecules that are active against rheumatoid arthritis-dependent pain, new dual inhibitors incorporating both a carbonic anhydrase (CA)-binding moiety and a cyclooxygenase inhibitor (NSAID) were tested in a rat model of rheumatoid arthritis induced by CFA intra-articular (i.a.) injection. Read More

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http://dx.doi.org/10.3390/ijms20081923DOI Listing
April 2019
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Prevalence and predictors for sustained remission in rheumatoid arthritis.

PLoS One 2019 19;14(4):e0214981. Epub 2019 Apr 19.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.

Objective: Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as the preferred sequelae of short-term remission. However little is known about the predictors of sustained remission for patients reaching remission. Using two independent cohorts, we aimed to evaluate the prevalence and predictors for sustained remission. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214981PLOS
April 2019
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3.234 Impact Factor

GdX/UBL4A-knockout mice resist collagen-induced arthritis by balancing the population of T1/T17 and regulatory T cells.

FASEB J 2019 Apr 19:fj201802217RR. Epub 2019 Apr 19.

State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.

Rheumatoid arthritis (RA) is an autoimmune disease associated with synovial hyperplasia and bone and cartilage destruction. T cells, notably T helper (T)-1 and T17 cells, play a critical role in the pathologic process of RA. However, it remains unclear how T1 and T17 cells are regulated during RA. Read More

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http://dx.doi.org/10.1096/fj.201802217RRDOI Listing

Abatacept alleviates rheumatoid arthritis development by inhibiting migration of fibroblast-like synoviocytes via MAPK pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3105-3111

Department of Rheumatology, Yantaishan Hospital, Yantai, China.

Objective: To investigate whether Abatacept could regulate the occurrence and progression of rheumatoid arthritis (RA) by mediating cell migration of fibroblast-like synoviocytes (FLS) via mitogen-activated protein kinase (MAPK) pathway.

Patients And Methods: Levels of MMP1, MMP3 and MMP13 in RA-FLS treated with Abatacept or MAPK pathway inhibitor were detected by quantitative Real-time-polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The regulatory effect of Abatacept on MAPK pathway was detected by Western blot. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17594DOI Listing