149,368 results match your criteria Arthritis Rheumatoid


[Inflammatory Muscle Pain: Polymyalgia Rheumatica with or without Large Vessel Vasculitis].

Dtsch Med Wochenschr 2020 Jul 2;145(13):895-902. Epub 2020 Jul 2.

Polymyalgia rheumatica (PMR) is characterized by rapidly evolving shoulder and pelvic girdle pain with fatigue, weight loss, night sweats and elevated CRP and ESR. Giant cell arteritis (GCA) can occur in PMR and vice versa. Headache and scalp tenderness are typical for GCA. Read More

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http://dx.doi.org/10.1055/a-1074-7685DOI Listing

Neutrophil-targeted engineered prodrug nanoparticles for anti-inflammation.

Authors:
Jinping Shi Juan Li

FASEB J 2020 Jul 2. Epub 2020 Jul 2.

Advanced Research Institute for Multidisciplinary Science, Beijing Institute of Technology, Beijing, China.

Inflammation response is a defense to infection induced by invading pathogen or tissue injury. However, exaggerated inflammation may cause autoimmune or inflammatory disorders, such as acute respiratory distress syndrome, sepsis, stroke and rheumatoid arthritis. Anti-inflammatory agents and anti-cytokine therapy have been developed to inhibit inflammation pathways and neutralize cytokine storm, but the off-targeting delivery and damage in immune system cause systemic severe side-effect. Read More

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http://dx.doi.org/10.1096/fj.202000978RRDOI Listing

Novel methodology to perform incurred sample reanalysis (ISR) on dried blood spot (DBS) cards - Experimental data using darolutamide and filgotinib.

Biomed Chromatogr 2020 Jul 2:e4938. Epub 2020 Jul 2.

Drug Metabolism and Pharmacokinetics, Jubilant Biosys, Industrial Suburb, Yeshwanthpur, Bangalore, India.

Different options on doing incurred sample reanalysis (ISR) on dried blood spot (DBS) cards were investigated using drugs belonging to various therapeutic areas: (a) darolutamide (to treat prostate cancer) and (b) filgotinib (to treat rheumatoid arthritis). The proposed novel methodology included the generation of half-DBS and quarter-DBS discs after initial blood collection using the full-DBS disc. Accordingly, blood collection via DBS was performed in male Sprague Dawley rats following intravenous and oral dosing of darolutamide; in male Balb/C mice following intravenous and oral dosing of filgotinib. Read More

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http://dx.doi.org/10.1002/bmc.4938DOI Listing

Risk factors of postoperative delayed wound healing in patients with rheumatoid arthritis treated with a biological agent.

Mod Rheumatol 2020 Jul 2:1-14. Epub 2020 Jul 2.

Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Objectives: This retrospective study aimed to investigate the risk factors associated with delayed wound healing (DWH) after orthopedic surgery in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs).

Methods: We reviewed medical records of 276 orthopedic procedures for 187 RA patients treated with bDMARDs. As a preoperative nutritional status assessment, we evaluated body mass index (BMI), prognostic nutritional index (PNI), and controlling nutritional status (CONUT). Read More

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http://dx.doi.org/10.1080/14397595.2020.1790138DOI Listing

Elevating the role of carers in rheumatoid arthritis management in the Asia-Pacific region.

Int J Rheum Dis 2020 Jul 1. Epub 2020 Jul 1.

Johnson & Johnson Pte Ltd, Singapore, Singapore.

Aim: Carers may offer valuable insight into the true health status of patients with rheumatoid arthritis (RA). This multinational, multi-stakeholder, exploratory study in Australia, China and Japan aimed to enrich our understanding of the role and potential impact of carers on RA management.

Method: This study used a 2-phase sequential mixed methods approach involving 3 key stakeholder groups: rheumatologists, RA patients and carers. Read More

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http://dx.doi.org/10.1111/1756-185X.13893DOI Listing

The impact of gender on the clinical presentation, management, and surgical outcomes of patients with native-joint septic arthritis.

J Eval Clin Pract 2020 Jul 1. Epub 2020 Jul 1.

Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

Rationale, Aims And Objectives: Approximately 20 000 cases of septic arthritis (SA) occur in the U.S. yearly. Read More

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http://dx.doi.org/10.1111/jep.13437DOI Listing

Rhodojaponin II inhibits TNF-α-induced inflammatory cytokine secretion in MH7A human rheumatoid arthritis fibroblast-like synoviocytes.

J Biochem Mol Toxicol 2020 Jul 2:e22551. Epub 2020 Jul 2.

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, China.

Rhodojaponin II (R-II) has been shown to possess anti-inflammatory activity. Herein, we aimed to explore the effect of R-II on tumor necrosis factor-α (TNF-α)-induced inflammation in MH7A rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs). We found that R-II treatment at high concentration suppressed the viability of MH7A cells. Read More

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http://dx.doi.org/10.1002/jbt.22551DOI Listing

The Use of Augmented Reality to Raise Awareness of the Differences Between Osteoarthritis and Rheumatoid Arthritis.

Adv Exp Med Biol 2020 ;1262:115-147

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Arthritis is one of the most common disease states worldwide but is still publicly misunderstood and lacks engaging public awareness materials. Within the UK, the most prevalent types of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA). The two are commonly mistaken as the same disease but, in fact, have very different pathogenesis, symptoms and treatments. Read More

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http://dx.doi.org/10.1007/978-3-030-43961-3_6DOI Listing
January 2020

The multifaceted functional role of DNA methylation in immune-mediated rheumatic diseases.

Clin Rheumatol 2020 Jul 2. Epub 2020 Jul 2.

Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, IRCCS, via Manzoni 56, 20089 Rozzano, Milan, Italy.

Genomic predisposition cannot explain the onset of complex diseases, as well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodelling and non-coding RNA, are considered to be the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory diseases. The paradigmatic cases of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjogren's syndrome (SjS) and type-1 diabetes (T1D) share the loss of immunological tolerance to self-antigen influenced by several factors, with a largely incomplete role of individual genomic susceptibility. Read More

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http://dx.doi.org/10.1007/s10067-020-05255-5DOI Listing

Risk factors for cervical spine instability in patients with rheumatoid arthritis.

Clin Rheumatol 2020 Jun 29. Epub 2020 Jun 29.

Division of Rheumatology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Introduction: Cervical spine (C-spine) instability is a unique and significant characteristic of rheumatoid arthritis (RA) because its occurrence is not rare and it can cause compressive cervical myelopathy, which may lead to serious neurologic sequelae. This study evaluated the prevalence and risk factors of C-spine instabilities in RA patients with a focus on anti-citrullinated protein antibody (ACPA) and biologic disease-modifying antirheumatic drug (DMARD) therapies.

Methods: The presence of C-spine instabilities in 1114 patients with RA was evaluated using C-spine radiographies according to the defined metrics. Read More

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http://dx.doi.org/10.1007/s10067-020-05243-9DOI Listing

Potential role of mitochondria in synoviocytes.

Clin Rheumatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Orthopedic, the First Affiliated Hospital of University of South China, No. 69, Chuanshan Road, Hengyang City, 421001, Hunan Province, China.

Synoviocytes are located in the synovium lining layer, which is composed of macrophage-like synoviocytes (MLS) and fibroblast-like synoviocytes (FLS) with different characteristics. Mitochondria, which exist in most cells, are two membrane-covered organelles. In addition to providing the necessary ATP for synoviocytes, mitochondria are involved in the regulation of redox homeostasis and the integration of synoviocytes death signals. Read More

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http://dx.doi.org/10.1007/s10067-020-05263-5DOI Listing

Rheumatoid arthritis and pyoderma gangrenosum: a population-based case-control study.

Clin Rheumatol 2020 Jul 1. Epub 2020 Jul 1.

Clalit Health Services, Tel-Aviv, Israel.

Background: The association between pyoderma gangrenosum (PG) and rheumatoid arthritis (RA) was not investigated in the setting of controlled studies. The risk of PG among patients with RA is not established.

Objective: The study aims to evaluate the magnitude of the association between RA and the subsequent development of PG. Read More

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http://dx.doi.org/10.1007/s10067-020-05253-7DOI Listing

Patient-Initiated Follow-Up (PIFU) as reorganized support for increased patient involvement - focus group discussions among patients' with inflammatory arthritis.

BMC Rheumatol 2020 30;4:44. Epub 2020 Jun 30.

Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.

Background: Inflammatory Arthritis is characterized by lifelong medical treatment and an unpredictable trajectory because of the fluctuating nature of the diseases. Proactive disease management is recommended, which includes close monitoring of disease activity that traditionally has been ensured by outpatient visits to rheumatologists at various fixed intervals. Internationally, there is a growing interest in how healthcare systems can be more flexible, individual-oriented and increasingly involve patients with lifelong diseases in their own treatment and care. Read More

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http://dx.doi.org/10.1186/s41927-020-00143-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325086PMC

Doubtful swelling on clinical examination reflects synovitis in rheumatoid arthritis.

Ther Adv Musculoskelet Dis 2020 22;12:1759720X20933489. Epub 2020 Jun 22.

Department of Rheumatology, Medical University of Vienna, Vienna, Austria.

Aims: The aim of this study was to evaluate the implication of doubtful joint swelling on clinical examination with respect to objective markers of synovitis by ultrasound (US) in patients with rheumatoid arthritis (RA).

Methods: Two independent observers performed a modified 28 swollen joint assessment (28SJC), in which joints could be graded as either definitely swollen, non-swollen, or doubtfully swollen. Two examiners blinded to clinical information performed US assessment of the hands. Read More

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http://dx.doi.org/10.1177/1759720X20933489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309376PMC

Rheumatoid Arthritis as a Risk Factor for Coronary Artery Calcification and Obstructive Coronary Artery Disease in Patients with Chest Pain: A Registry Based Cross-Sectional Study.

Clin Epidemiol 2020 24;12:679-689. Epub 2020 Jun 24.

Department of Cardiology, Hospital Unit West, Herning, Denmark.

Purpose: To examine the occurrence and severity of coronary artery disease (CAD) in patients with rheumatoid arthritis (RA) compared to non-RA patients in a population referred for coronary computed tomography angiography (CTA) due to chest pain.

Patients And Methods: In this cross-sectional study, 46,210 patients from a national CTA database were included. Patients with RA were stratified on serology, treatment with conventional synthetic or biological disease-modifying antirheumatic drugs (DMARDs), and the need for relapse or flare treatment with intraarticular or -muscular glucocorticoid injections (GCIs). Read More

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http://dx.doi.org/10.2147/CLEP.S251168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322143PMC

Factors Associated with Nutrition of Japanese Patients with Rheumatoid Arthritis Who Underwent the Mini Nutritional Assessment (MNA), Health Assessment Questionnaire Disability Index, and Body Composition Assessment by Bioelectrical Impedance Analysis.

J Nutr Sci Vitaminol (Tokyo) 2020 ;66(3):219-223

Department of Orthopedic Surgery, Tokyo Women's Medical University.

The aim of this study is to identify the factors associated with nutrition in Japanese patients with rheumatoid arthritis (RA). Overall, 409 patients with RA who underwent the Mini Nutritional Assessment (MNA), bone mineral density determination, and body composition assessment by bioelectrical impedance analysis were enrolled. The analysis of factors associated with malnutrition was performed by comparing groups categorized by MNA score (≥24, 17-23. Read More

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http://dx.doi.org/10.3177/jnsv.66.219DOI Listing
January 2020

Relationship of pain and fatigue with health-related quality of life and work in patients with psoriatic arthritis on TNFi: results of a multi-national real-world study.

RMD Open 2020 Jun;6(2)

Immunology/Rheumatology, Stanford University, Stanford, California, USA.

Background/objective: The incidence of pain and/or fatigue in people with psoriatic arthritis (PsA) is associated with reduced health-related quality of life (HRQoL) and the ability to work, despite modern advanced therapeutic approaches. This real-world, international study examined these relationships in patients with PsA treated with tumour necrosis factor inhibitors (TNFi).

Methods: Data from 13 countries were analysed. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001240DOI Listing

Methotrexate: what are the true risks of treatment?

Ann Rheum Dis 2020 Jul 1. Epub 2020 Jul 1.

Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2020-217207DOI Listing

Hydroxychloroquine for COVID-19: What is our Current State of Knowledge?

J Assoc Physicians India 2020 Jun;68(6):48-52

Dean, Indian College of Physicians; Consultant Endocrinologist, Lilavati and Bhatia Hospital, Mumbai, Maharashtra.

Chloroquine and Hydroxychloroquine are drugs which have been widely used in malaria and rheumatoid arthritis respectively for over 50 years. There was anecdotal evidence of their efficacy in the earlier SARS outbreak in 2003. This prompted physicians from across the world to use them in the present SARS-CoV- 2 pandemic that is currently sweeping the globe, with 5 million people already infected to date. Read More

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Obesity and Morbidity Risk in the U.S. Veteran.

Healthcare (Basel) 2020 Jun 29;8(3). Epub 2020 Jun 29.

School of Health Administration, Texas State University, San Marcos, TX 78666, USA.

The obesity epidemic in the United States has been well documented and serves as the basis for a number of health interventions across the nation. However, those who have served in the U.S. Read More

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http://dx.doi.org/10.3390/healthcare8030191DOI Listing

The Potential Effect of Aberrant Testosterone Levels on Common Diseases: A Mendelian Randomization Study.

Genes (Basel) 2020 Jun 29;11(7). Epub 2020 Jun 29.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China.

Testosterone has historically been linked to sexual dysfunction; however, it has recently been shown to affect other physical and mental attributes. We attempted to determine whether changes in serum testosterone could play a role in chronic or degenerative diseases. We used two separate genetic instruments comprising of variants from and regions and conducted a two-sample Mendelian randomization for type II diabetes (T2D), gout, rheumatoid arthritis (RA), schizophrenia, bipolar disorder, Alzheimer's disease and depression. Read More

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http://dx.doi.org/10.3390/genes11070721DOI Listing

An imbalance between blood CD4CXCR5Foxp3 Tfr cells and CD4CXCR5Tfh cells may contribute to the immunopathogenesis of rheumatoid arthritis.

Mol Immunol 2020 Jun 27;125:1-8. Epub 2020 Jun 27.

Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China. Electronic address:

Background: Follicular helper T (Tfh) cells are a subgroup of activated CD4 T cells which can assist the formation and maintenance of germinal centers. Follicular regulatory T (Tfr) cells are a new class of regulatory T cells which play a major role in suppressing cells in humoral immunity. In contrast to the role of Tfh cells, Tfr cells can inhibit the function of Tfh cells and B cells. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.06.003DOI Listing

Epigenetic and transcriptional regulation of osteoclast genesis in the pathogenesis of skeletal diseases: A systematic review.

Bone 2020 Jun 28:115507. Epub 2020 Jun 28.

Department of Orthopedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: To identify epigenetic and transcriptional factors controlling osteoclastogenesis (OCG), that have been shown to play a role in the pathogenesis of skeletal diseases.

Methods: A systematic review was conducted in accordance with the PRISMA guidelines. The PubMed and EMBASE databases were searched up to 30th April 2020; references of included articles and pertinent review articles were also screened to identify eligible studies. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115507DOI Listing

Do ankle, hindfoot, and heel ultrasound findings predict the symptomatology and quality of life in rheumatoid arthritis patients?

J Ultrason 2020 15;20(81):e70-e82. Epub 2020 Jun 15.

2nd Internal Medicine Department, "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania.

To evaluate the ankle, hindfoot, and heel changes (determined by physical examination, ultrasound and baropodometry) in patients with rheumatoid arthritis, to compare the findings with healthy subjects, and to analyze if these findings are associated with ankle pain and could affect the quality of life. We enrolled 35 rheumatoid arthritis patients and 35 healthy controls, and evaluated their ankles (tibiotalar joints, tendons), hindfeet (talonavicular, subtalar joints) and heels using clinical examination, DAS28-CRP, RAPID3 for the evaluation of functional status, quality of life in rheumatoid arthritis questionnaire, ultrasound, and baropodometry. The ultrasound inter-observer agreement was good for the subtalar joint, and very good for the other structures. Read More

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http://dx.doi.org/10.15557/JoU.2020.0012DOI Listing

Golimumab improves socio economic and health economic parameters in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

Curr Med Res Opin 2020 Jul 1. Epub 2020 Jul 1.

MSD Sharp & Dohme GmbH, Haar, Germany.

Golimumab (GLM) has shown its efficacy and safety in various clinical trials. We aimed to assess the effect of GLM on socioeconomic and health economic parameters in daily clinical practice. Rheumatology offices in Germany. Read More

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http://dx.doi.org/10.1080/03007995.2020.1790347DOI Listing

Localization of Therapeutic Fab-CHP Conjugates to Sites of Denatured Collagen for the Treatment of Rheumatoid Arthritis.

Bioconjug Chem 2020 Jul 1. Epub 2020 Jul 1.

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation in synovial joints and protease-induced cartilage degradation. Current biologic treatments for RA can effectively reduce symptoms, primarily by neutraliz-ing the proinflammatory cytokine TNFα; however, continued, indiscriminate over-inhibition of inflammatory factors can significantly weaken the host immune system, leading to opportunistic infections and interrupting treatment. We hypothesize that localizing anti-TNFα therapeutics to denatured collagen (dCol) present at arthritic joints, via conjugation with collagen-hybridizing peptides (CHPs), will reduce off-site antigen binding and maintain local immunosuppression. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.0c00324DOI Listing

A case of new-onset vitiligo in a patient on tofacitinib and brief review of paradoxical presentations with other novel targeted therapies.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Department of Dermatology, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX.

With recent advancements in the understanding of vitiligo pathogenesis, Janus kinase (JAK) inhibitors have emerged as a promising new treatment modality, but their effects remain incompletely elucidated. Tofacitinib, an oral JAK 1/3 inhibitor approved for the treatment of rheumatoid arthritis, has previously been shown to induce significant re-pigmentation in vitiligo. However, as with other novel targeted therapies, cutaneous adverse effects have been observed. Read More

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Linc02381 Exacerbates Rheumatoid Arthritis Through Adsorbing miR-590-5p and Activating the Mitogen-Activated Protein Kinase Signaling Pathway in Rheumatoid arthritis-fibroblast-like synoviocytes.

Authors:
Jing Wang Qing Zhao

Cell Transplant 2020 Jan-Dec;29:963689720938023

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, People's Republic of China.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. New evidence suggested that linc02381 suppressed colorectal cancer progression by regulating PI3 K signaling pathway, but the role of linc02381 in other diseases, such as RA, remains unclear. This study aimed to reveal the mechanism of linc02381 in RA progression. Read More

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http://dx.doi.org/10.1177/0963689720938023DOI Listing

[Bronchiectasis - a review].

Laeknabladid 2020 Jul;106(7):352-361

Department of Radiology Karolinska University Hospital Stockholm, Sweden.

Bronchiectasis is a disease that is characterized by permanent bronchial dilation. This can be localized or diffuse in the lungs. The disease can occur at any age and causes cough, sputum production and repeated infections. Read More

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http://dx.doi.org/10.17992/lbl.2020.0708.592DOI Listing

Long non-coding RNA MEG3 and its genetic variant rs941576 are associated with rheumatoid arthritis pathogenesis in Egyptian patients.

Arch Physiol Biochem 2020 Jul 1:1-8. Epub 2020 Jul 1.

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Rheumatoid arthritis (RA) is a joint destructive disorder. This study aimed to assess lncRNA MEG3 expression and its variant rs941576 in Egyptian patients with RA. 100 RA patients and 100 healthy individuals were enrolled in the study. Read More

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http://dx.doi.org/10.1080/13813455.2020.1784951DOI Listing

Perfusion in hand arthritis on dynamic contrast-enhanced computed tomography: a randomized prospective study using MRI as a standard of reference.

Skeletal Radiol 2020 Jun 30. Epub 2020 Jun 30.

Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt - Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.

Objective: To evaluate the performance of dynamic contrast-enhanced CT (DCE-CT) in detecting and quantitatively assessing perfusion parameters in patients with arthritis of the hand compared with dynamic contrast-enhanced MRI (DCE-MRI) as a standard of reference.

Materials And Methods: In this IRB-approved randomized prospective single-centre study, 36 consecutive patients with suspected rheumatoid arthritis underwent DCE-CT (320-row, tube voltage 80 kVp, tube current 8.25 mAs) and DCE-MRI (1. Read More

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http://dx.doi.org/10.1007/s00256-020-03526-5DOI Listing

Parameters matter: modulating cytokines using nerve stimulation.

Authors:
Bruno Bonaz

Bioelectron Med 2020 26;6:12. Epub 2020 Jun 26.

University Grenoble Alpes, Inserm, U1216, Grenoble Institute Neurosciences and Division of Hepato-Gastroenterology, CHU Grenoble Alpes, 38000 Grenoble, France.

The vagus nerve-based inflammatory reflex regulates inflammation and cytokine release. Recent successful clinical trials using implantable bioelectronic devices to modulate the inflammatory reflex in patients with rheumatoid arthritis and inflammatory bowel disease have demonstrated the efficacy of targeting neural circuits as an efficient alternative to drug treatments. However, the optimal vagus nerve stimulation parameters to achieve efficacious symptomatic relief for inflammation are still unknown. Read More

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http://dx.doi.org/10.1186/s42234-020-00049-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318398PMC

Type I allergic reaction to rituximab upon first lifetime exposure: a case report.

Allergy Asthma Clin Immunol 2020 26;16:56. Epub 2020 Jun 26.

Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, McGill University, Montreal, QC Canada.

Background: While drug reactions to rituximab have been commonly reported in the literature, a type I allergic reaction to rituximab after first lifetime exposure has never been reported.

Case Presentation: We describe a case of a 58-year-old female patient who received rituximab for the first time for treatment of rheumatoid arthritis. She developed symptoms immediately after infusion, however presented 11 days after drug exposure with cyclical anaphylaxis-like reaction requiring multiple doses of epinephrine. Read More

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http://dx.doi.org/10.1186/s13223-020-00448-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318363PMC

Functional Disability and Its Determinants in Ecuadorian Patients with Rheumatoid Arthritis.

Open Access Rheumatol 2020 10;12:97-104. Epub 2020 Jun 10.

Rheumatology Department, Universidad Espiritu Santo, Guayaquil, Ecuador.

Introduction: Disability in RA is associated with loss of workdays, greater use of health resources and a higher prevalence of depression. The purpose of this study was to determine the prevalence of functional disability and the factors associated with it.

Methods: A cross-sectional study was carried out during January-June 2019 at a rheumatology clinic in the city of Guayaquil. Read More

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http://dx.doi.org/10.2147/OARRR.S251725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293966PMC

A Case of Rhupus with Rowell Syndrome.

Open Access Rheumatol 2020 9;12:91-96. Epub 2020 Jun 9.

Division of Rheumatology, Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Jeddah, Saudi Arabia.

We report a case of 30-year-old female who presented initially with hair loss, photosensitive malar rash, morning stiffness and synovitis. She was diagnosed with Rhupus syndrome based on clinical and laboratory findings. Few months after starting hydroxychloroquine, esomeprazole and azathioprine, and failing methotrexate (because of erosive pill-induced esophagitis), she presented with generalized maculopapular dusky reddish rash in her body, back and extremities. Read More

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http://dx.doi.org/10.2147/OARRR.S255790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293421PMC

Satisfaction of Patients and Physicians with Treatments for Rheumatoid Arthritis: A Population-Based Survey in China.

Patient Prefer Adherence 2020 23;14:1037-1047. Epub 2020 Jun 23.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.

Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by chronic destructive synovitis and possible multisystem involvement. This study aimed to survey the treatment satisfaction of physicians and patients with RA, and to explore the potential factors.

Patients And Methods: This cross-sectional study was conducted in 12 centers across China between March 2018 and April 2018. Read More

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http://dx.doi.org/10.2147/PPA.S232578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320887PMC

Response to: 'Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis' by Györfi .

Ann Rheum Dis 2020 Jun 30. Epub 2020 Jun 30.

Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia

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http://dx.doi.org/10.1136/annrheumdis-2020-218328DOI Listing

The establishment of a rheumatoid arthritis primate model in Macaca fascicularis.

J Transl Med 2020 Jun 30;18(1):264. Epub 2020 Jun 30.

Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their close phylogenetic relationship to humans in terms of cross-reactivity to compounds developed using modern drug technologies.

Methods: We used a collagen-induced arthritis (CIA) model in Macaca fascicularis. Read More

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http://dx.doi.org/10.1186/s12967-020-02402-zDOI Listing

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases.

BMC Musculoskelet Disord 2020 Jun 30;21(1):416. Epub 2020 Jun 30.

Division of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Tianhe District, Guangzhou, 510630, China.

Backgroud: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.

Method: A cross-sectional study recruits 1398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Read More

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http://dx.doi.org/10.1186/s12891-020-03403-1DOI Listing

A case of Asthma with Behcet's disease: successful treatment with Omalizumab and its effects on recurrent aphthous lesions.

Immunopharmacol Immunotoxicol 2020 Jul 1:1-12. Epub 2020 Jul 1.

Department of Infectious Diseases and Clinical Microbiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Monoclonal antibody therapies have revolutionized the treatment of autoinflammatory-immune/genetic disease including spondylarthritis, asthma and rheumatoid arthritis. Behcet's disease (BD) is a multi-systemic vasculitis, which is generally recurrent aphthous lesions (RAL) as well as ocular and skin lesions. Today, the immunohistopathogenesis of BD is mostly unknown. Read More

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http://dx.doi.org/10.1080/08923973.2020.1789656DOI Listing

Interleukin-17 Gene Polymorphism (Rs2275913 G/A, Rs763780 C/T) in Rheumatoid arthritis:Meta-analysis Based on Ethnicity.

Immunol Invest 2020 Jul 1:1-15. Epub 2020 Jul 1.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei, Anhui, China.

Introduction: The association between interleukin()-17A and F gene polymorphism with rheumatoid arthritis (RA) were inconsistent among previous studies. This meta-analysis aimed to determine the association between A and F gene polymorphism with RA.

Methods: We searched Medline up to February 2020. Read More

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http://dx.doi.org/10.1080/08820139.2020.1786397DOI Listing

Osteoporosis in patients with rheumatoid arthritis: an update in epidemiology, pathogenesis, and fracture prevention.

Expert Opin Pharmacother 2020 Jul 1:1-13. Epub 2020 Jul 1.

Department of Rheumatology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Rheumatology and Immunology Center , Amsterdam, The Netherlands.

Introduction: Rheumatoid arthritis (RA) is a chronic disabling disease characterized by a symmetrical articular involvement due to ongoing joint inflammation, if left insufficiently treated. Local and generalized bone loss is one of the main extra-articular complications of RA and leads to an increased risk for fragility fractures, which further impair functional ability, quality of life, and life expectancy. Therefore, there is an urgent need for good fracture risk management in the vulnerable RA patient. Read More

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http://dx.doi.org/10.1080/14656566.2020.1787381DOI Listing

Necrobiosis Lipoidica in a Patient with β-Thalassemia Major: A Case Report and Review of the Literature.

Hemoglobin 2020 Jul 1:1-3. Epub 2020 Jul 1.

Adult Thalassemia Unit, Second Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Necrobiosis lipoidica (NL) is a rare granulomatous disease that predominantly affects middle-aged women and is often associated with diabetes mellitus (DM), rheumatoid arthritis (RA) and other metabolic disorders. Thalassemias are the most common hereditary hemoglobin (Hb) disorders worldwide. A few studies investigated dermatologic problems that coexist with β-thalassemia major (β-TM). Read More

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http://dx.doi.org/10.1080/03630269.2020.1783287DOI Listing

Background Glucocorticoid Therapy Has No Impact on Efficacy and Safety of Abatacept or Adalimumab in Patients with Rheumatoid Arthritis.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Rheumatology Centre, Toulouse University Hospital and University Toulouse III Paul Sabatier, 31059 Toulouse, France.

To date, the impact of background glucocorticoids (GC) on the efficacy and safety of abatacept or adalimumab in patients with active rheumatoid arthritis (RA) is not clearly established. This post hoc analysis of (AMPLE) trial (NCT00929864) compared efficacy and safety outcomes over 2 years in patients treated with abatacept or adalimumab plus background methotrexate (MTX), who continued GC (≤10 mg/day) versus those who were not receiving GC (no-GC). Of 646 randomized patients, 317 received abatacept + MTX (161 GC, 156 no-GC) and 326 received adalimumab + MTX (162 GC, 164 no-GC). Read More

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http://dx.doi.org/10.3390/jcm9062017DOI Listing

Systemic Manifestations and Complications in Patients with Rheumatoid Arthritis.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Korea.

Rheumatoid arthritis (RA) is a systemic autoimmune disease with symmetrical peripheral polyarthritis, predominantly involving the small joints [... Read More

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http://dx.doi.org/10.3390/jcm9062008DOI Listing

Anti-Cyclic Citrullinated Peptide Antibodies Correlate to Ultrasound Synovitis in Rheumatoid Arthritis Better Than C-Reactive Protein.

J Clin Rheumatol 2020 Jun 23. Epub 2020 Jun 23.

From the Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital.

Objectives: The aim of this study was to compare ultrasound (US) grading and laboratory measures in patients with rheumatoid arthritis.

Methods: Two-hundred four patients with rheumatoid arthritis who received US evaluation for synovitis were included after excluding those using tocilizumab. Ultrasound grading of synovial hypertrophy (SH) and power Doppler (PD) at the most severe site were recorded. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001499DOI Listing

Biologic Agents Reduce Cardiovascular Events in Rheumatoid Arthritis Not Responsive to Tumour Necrosis Factor Inhibitors: A National Cohort Study.

Can J Cardiol 2020 Jan 15. Epub 2020 Jan 15.

Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan; Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan; Graduate Institute of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan. Electronic address:

Background: Tumour necrosis factor inhibitors (TNFis) improve joints outcomes and reduce cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). However, 20%-45% of RA patients are TNFi poor responders and have a significantly higher risk of CV events. In these TNFi nonresponders, the use of second-line biologic agents to improve synovial outcomes is supported by clinical trials and real-world experience. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.01.003DOI Listing
January 2020

Rheumatoid Arthritis: Pathogenesis, Prediction and Prevention - An Emerging Paradigm Shift.

Arthritis Rheumatol 2020 Jun 30. Epub 2020 Jun 30.

Division of Rheumatology, University of Colorado Denver School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.

Rheumatoid arthritis (RA) is currently diagnosed and treated when an individual presents to health care with signs and symptoms of inflammatory arthritis (IA) as well as other features such as autoantibodies and/or imaging findings that provide sufficient confidence that the individual has RA-like IA (e.g. meeting established classification criteria) that warrants therapy. Read More

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http://dx.doi.org/10.1002/art.41417DOI Listing