J Hepatol 2022 Jun 21. Epub 2022 Jun 21.
Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), Donostia-San Sebastian, Spain; CIBERehd, Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, Leioa, Spain. Electronic address:
Background & Aims: Cholestatic liver injury triggers a wound healing response orchestrated by Kupffer cells (KCs), hepatic stellate cells (HSCs) and other immune cells that leads to peribiliary fibrosis and disease progression. Inflammation is central, particularly that mediated by bacterial components translocating from the gut to the liver, binding to toll-like receptors (TLRs). The triggering receptor expressed on myeloid cells-2 (TREM-2) inhibits TLR-mediated signaling and exerts a protective role in hepatocellular injury and carcinogenesis. Read More